ZCCHC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42434730
2mitochondrial respiratory chain complex I assembly (GO:0032981)4.42434730
3NADH dehydrogenase complex assembly (GO:0010257)4.42434730
4kinetochore organization (GO:0051383)4.31253264
5replication fork processing (GO:0031297)4.27987919
6protein complex biogenesis (GO:0070271)4.27839122
7protein-cofactor linkage (GO:0018065)4.23311588
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.16295894
9mitochondrial respiratory chain complex assembly (GO:0033108)4.11352816
10nuclear pore complex assembly (GO:0051292)4.10104727
11regulation of nuclear cell cycle DNA replication (GO:0033262)4.04399980
12maturation of 5.8S rRNA (GO:0000460)4.02847518
13respiratory chain complex IV assembly (GO:0008535)3.95305544
14water-soluble vitamin biosynthetic process (GO:0042364)3.89908396
15behavioral response to nicotine (GO:0035095)3.88892057
16kinetochore assembly (GO:0051382)3.85559580
17nuclear pore organization (GO:0006999)3.79569534
18protein localization to kinetochore (GO:0034501)3.79555335
19meiotic chromosome segregation (GO:0045132)3.76761535
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72944787
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70103884
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.67899349
23mitotic sister chromatid cohesion (GO:0007064)3.66216316
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63721996
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63721996
26regulation of DNA endoreduplication (GO:0032875)3.57564701
27pseudouridine synthesis (GO:0001522)3.53710888
28DNA double-strand break processing (GO:0000729)3.52317737
29pore complex assembly (GO:0046931)3.41341644
30protein localization to chromosome, centromeric region (GO:0071459)3.41103411
31cytochrome complex assembly (GO:0017004)3.40485736
32proteasome assembly (GO:0043248)3.38606533
33rRNA modification (GO:0000154)3.38504632
34mitotic metaphase plate congression (GO:0007080)3.34896307
35rRNA catabolic process (GO:0016075)3.32523567
36histone H3-K4 trimethylation (GO:0080182)3.29769586
37platelet dense granule organization (GO:0060155)3.29332277
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.28852714
39recombinational repair (GO:0000725)3.24163786
40double-strand break repair via homologous recombination (GO:0000724)3.21961931
41rRNA methylation (GO:0031167)3.19497160
42telomere maintenance via semi-conservative replication (GO:0032201)3.15959260
43CENP-A containing nucleosome assembly (GO:0034080)3.14727099
44centriole replication (GO:0007099)3.11972579
45DNA replication initiation (GO:0006270)3.11303624
46mitotic nuclear envelope disassembly (GO:0007077)3.10647992
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.10647783
48mitotic recombination (GO:0006312)3.10622824
49chromatin remodeling at centromere (GO:0031055)3.10298776
50telomere maintenance via recombination (GO:0000722)3.08608578
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07505708
52regulation of histone H3-K27 methylation (GO:0061085)3.06941873
53resolution of meiotic recombination intermediates (GO:0000712)3.05818183
54mismatch repair (GO:0006298)3.05189093
55tRNA processing (GO:0008033)3.04805888
56peptidyl-histidine modification (GO:0018202)3.03809793
57metaphase plate congression (GO:0051310)3.00598161
58response to pheromone (GO:0019236)2.99531755
59protein polyglutamylation (GO:0018095)2.98601097
60DNA catabolic process, exonucleolytic (GO:0000738)2.98592552
61tRNA methylation (GO:0030488)2.97217685
62protein K11-linked deubiquitination (GO:0035871)2.96818995
63reciprocal DNA recombination (GO:0035825)2.96347378
64reciprocal meiotic recombination (GO:0007131)2.96347378
65mitochondrial RNA metabolic process (GO:0000959)2.94814682
66IMP biosynthetic process (GO:0006188)2.93705466
67DNA replication-independent nucleosome organization (GO:0034724)2.93515244
68DNA replication-independent nucleosome assembly (GO:0006336)2.93515244
69DNA strand elongation involved in DNA replication (GO:0006271)2.93302940
70cullin deneddylation (GO:0010388)2.90880995
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90380825
72regulation of helicase activity (GO:0051095)2.90031943
73regulation of spindle organization (GO:0090224)2.88409166
74ATP synthesis coupled proton transport (GO:0015986)2.87967753
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87967753
76regulation of histone H3-K9 methylation (GO:0051570)2.85783126
77mitotic sister chromatid segregation (GO:0000070)2.85625420
78DNA strand elongation (GO:0022616)2.83969427
79DNA replication checkpoint (GO:0000076)2.83719482
80termination of RNA polymerase I transcription (GO:0006363)2.82081672
81DNA strand renaturation (GO:0000733)2.81384813
82mitotic chromosome condensation (GO:0007076)2.81067583
83telomere maintenance via telomere lengthening (GO:0010833)2.80919008
84telomere maintenance (GO:0000723)2.80538944
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79987606
86intra-S DNA damage checkpoint (GO:0031573)2.79810045
87sister chromatid segregation (GO:0000819)2.78918561
88regulation of telomere maintenance (GO:0032204)2.77251739
89telomere organization (GO:0032200)2.77060365
90establishment of chromosome localization (GO:0051303)2.75200988
91nuclear envelope disassembly (GO:0051081)2.74279849
92membrane disassembly (GO:0030397)2.74279849
93DNA unwinding involved in DNA replication (GO:0006268)2.73703123
94DNA geometric change (GO:0032392)2.73146350
95fucose catabolic process (GO:0019317)2.72677543
96L-fucose metabolic process (GO:0042354)2.72677543
97L-fucose catabolic process (GO:0042355)2.72677543
98protein deneddylation (GO:0000338)2.72667800
99tRNA metabolic process (GO:0006399)2.72297103
100DNA duplex unwinding (GO:0032508)2.71658578
101peptidyl-lysine trimethylation (GO:0018023)2.71527832
102histone mRNA metabolic process (GO:0008334)2.71117010
103regulation of DNA-dependent DNA replication (GO:0090329)2.70697410
104positive regulation of histone H3-K4 methylation (GO:0051571)2.69644062
105histone exchange (GO:0043486)2.69629487
106ribosomal small subunit assembly (GO:0000028)2.68804053
107intraciliary transport (GO:0042073)2.68333520
108histone H2A acetylation (GO:0043968)2.67107583
109negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67000927
110spindle checkpoint (GO:0031577)2.66565500
111synapsis (GO:0007129)2.66414691
112histone H3-K9 methylation (GO:0051567)2.65687111
113DNA damage response, detection of DNA damage (GO:0042769)2.65670344
114protein K6-linked ubiquitination (GO:0085020)2.65367322
115single strand break repair (GO:0000012)2.62679770
116intracellular protein transmembrane import (GO:0044743)2.62257678
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61901276
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.60790146
119mannosylation (GO:0097502)2.60720870
120positive regulation of DNA-dependent DNA replication (GO:2000105)2.60669715
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59615454
122axoneme assembly (GO:0035082)2.58230257
123histone H3-K36 demethylation (GO:0070544)2.58123119
124regulation of mitotic spindle organization (GO:0060236)2.57104607
125neural tube formation (GO:0001841)2.56755710
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.56464832
127termination of RNA polymerase III transcription (GO:0006386)2.55191873
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.55191873
129regulation of mitotic spindle checkpoint (GO:1903504)2.55005082
130regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55005082
131tryptophan catabolic process (GO:0006569)2.54629328
132indole-containing compound catabolic process (GO:0042436)2.54629328
133indolalkylamine catabolic process (GO:0046218)2.54629328
134DNA synthesis involved in DNA repair (GO:0000731)2.54419607
135ncRNA catabolic process (GO:0034661)2.54050000
136organelle disassembly (GO:1903008)2.52358816
137isotype switching (GO:0045190)2.51763238
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51763238
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51763238
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51656993
141kynurenine metabolic process (GO:0070189)2.51494231
142positive regulation of histone methylation (GO:0031062)2.51121690
143pyrimidine dimer repair (GO:0006290)2.50802641
144spindle assembly checkpoint (GO:0071173)2.50722330
145telomere maintenance via telomerase (GO:0007004)2.50248700
146folic acid-containing compound biosynthetic process (GO:0009396)2.49963084
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.49767092
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49767092
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49767092
150negative regulation of sister chromatid segregation (GO:0033046)2.49767092
151regulation of centriole replication (GO:0046599)2.49027253
152negative regulation of telomere maintenance (GO:0032205)2.48357032
153negative regulation of chromosome segregation (GO:0051985)2.47953930
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47163771
155inner mitochondrial membrane organization (GO:0007007)2.46953642
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46571620
157mitotic spindle checkpoint (GO:0071174)2.46297741
158regulation of centrosome cycle (GO:0046605)2.46234332
159piRNA metabolic process (GO:0034587)2.46048141
160protein neddylation (GO:0045116)2.45669091
161RNA-dependent DNA replication (GO:0006278)2.45649375
162preassembly of GPI anchor in ER membrane (GO:0016254)2.43500434
163regulation of mitotic sister chromatid separation (GO:0010965)2.43234450
164regulation of mitotic sister chromatid segregation (GO:0033047)2.43234450
165regulation of sister chromatid segregation (GO:0033045)2.43234450
166tRNA modification (GO:0006400)2.42312615
167DNA recombination (GO:0006310)2.42257066
168IMP metabolic process (GO:0046040)2.41969492
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41741058
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41741058
171positive regulation of mitotic sister chromatid separation (GO:1901970)2.41741058
172protein localization to chromosome (GO:0034502)2.41686763
173negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41481230
174histone H3-K4 methylation (GO:0051568)2.41292662
175centriole assembly (GO:0098534)2.41275535
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.40820226
177mitotic spindle assembly checkpoint (GO:0007094)2.39358704
178regulation of DNA damage checkpoint (GO:2000001)2.37749210
179viral mRNA export from host cell nucleus (GO:0046784)2.37487555
180maturation of SSU-rRNA (GO:0030490)2.36955476
181regulation of chromatin silencing (GO:0031935)2.36790322
182regulation of histone H3-K4 methylation (GO:0051569)2.36785387
183DNA deamination (GO:0045006)2.36399854
184somatic hypermutation of immunoglobulin genes (GO:0016446)2.36291016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.63072749
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11182361
3ZNF274_21170338_ChIP-Seq_K562_Hela3.45237030
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42482634
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.34097036
6VDR_22108803_ChIP-Seq_LS180_Human2.95087740
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.88036937
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.86486480
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42062882
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.37683008
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33231431
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31620154
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28255401
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23401570
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.21693353
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20787690
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.18934792
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18259259
19IGF1R_20145208_ChIP-Seq_DFB_Human2.15831018
20FUS_26573619_Chip-Seq_HEK293_Human2.11641141
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11066674
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.06401839
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.05821631
24E2F7_22180533_ChIP-Seq_HELA_Human10.1384522
25* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98453074
26* VDR_23849224_ChIP-Seq_CD4+_Human1.98349877
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98175146
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97977131
29GBX2_23144817_ChIP-Seq_PC3_Human1.96821823
30FOXP3_21729870_ChIP-Seq_TREG_Human1.96204535
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.95398200
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88852287
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88659536
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86338654
35CIITA_25753668_ChIP-Seq_RAJI_Human1.85818384
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85625555
37ELK1_19687146_ChIP-ChIP_HELA_Human1.82437588
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81543522
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76283745
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73410186
41AR_21909140_ChIP-Seq_LNCAP_Human1.68991094
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68633073
43* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67353359
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67244376
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.67038737
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.66895691
47TAF15_26573619_Chip-Seq_HEK293_Human1.66784486
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62777782
49P300_19829295_ChIP-Seq_ESCs_Human1.62590932
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61718479
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59360452
52DCP1A_22483619_ChIP-Seq_HELA_Human1.56508879
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56447541
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56067620
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51071457
56SPI1_23547873_ChIP-Seq_NB4_Human1.50822814
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47055524
58SCL_19346495_ChIP-Seq_HPC-7_Human1.47023281
59ER_23166858_ChIP-Seq_MCF-7_Human1.46927576
60TP53_22573176_ChIP-Seq_HFKS_Human1.46549300
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46464190
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44135312
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42689726
64* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41755942
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40462296
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40331642
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39204812
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36693189
69XRN2_22483619_ChIP-Seq_HELA_Human1.34108793
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32610349
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31689421
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31145731
73TFEB_21752829_ChIP-Seq_HELA_Human1.31103206
74IRF1_19129219_ChIP-ChIP_H3396_Human1.28515889
75MYC_18940864_ChIP-ChIP_HL60_Human1.28324878
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27865191
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.27568334
78CBP_20019798_ChIP-Seq_JUKART_Human1.27086565
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27086565
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26725674
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24446453
82* TTF2_22483619_ChIP-Seq_HELA_Human1.23097258
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23036645
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22971404
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20276856
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18517422
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17907926
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17525713
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15644947
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14881057
91SOX2_19829295_ChIP-Seq_ESCs_Human1.13833801
92NANOG_19829295_ChIP-Seq_ESCs_Human1.13833801
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13329253
94* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11792046
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10871544
96STAT3_23295773_ChIP-Seq_U87_Human1.10690730
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10442748
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09751798
99* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09617546
100MYC_22102868_ChIP-Seq_BL_Human1.08522710
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08259084
102MYB_26560356_Chip-Seq_TH1_Human1.08241506
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.07921198
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06516275
105IRF8_27001747_Chip-Seq_BMDM_Mouse1.05240009
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03294576
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.02706209
108GABP_19822575_ChIP-Seq_HepG2_Human1.02589556
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.01137803
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00799435
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.00799435
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00784251
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00766986
114BCAT_22108803_ChIP-Seq_LS180_Human1.00141765
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99996977
116SMAD4_21799915_ChIP-Seq_A2780_Human0.99769621
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99561885
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99058481
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98990914
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98836139
121TCF4_23295773_ChIP-Seq_U87_Human0.98394533
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98231502
123TCF4_22108803_ChIP-Seq_LS180_Human0.98078111
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97061735
125AR_20517297_ChIP-Seq_VCAP_Human0.96980530
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96689730
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.96345278
128MYB_26560356_Chip-Seq_TH2_Human0.95790221
129EWS_26573619_Chip-Seq_HEK293_Human0.95715976
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95205034
131* YY1_21170310_ChIP-Seq_MESCs_Mouse0.94802581
132FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94405003
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93658893
134AR_25329375_ChIP-Seq_VCAP_Human0.93591953
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93383669
136P53_22387025_ChIP-Seq_ESCs_Mouse0.93290235
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92552242
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92397187
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91932963
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.91171597
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91033696
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90299504
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90290406
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90105379
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90062844
146NCOR_22424771_ChIP-Seq_293T_Human0.89880715
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89413555
148KDM5A_27292631_Chip-Seq_BREAST_Human0.88950974
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.88908351
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83878242
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83362681
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.80322866
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79736775
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77167517
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76958372
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76354542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96224118
2MP0008057_abnormal_DNA_replication3.71259675
3MP0003111_abnormal_nucleus_morphology3.65557546
4MP0000569_abnormal_digit_pigmentation3.53393584
5MP0010094_abnormal_chromosome_stability3.29818509
6MP0008058_abnormal_DNA_repair2.94706117
7MP0003077_abnormal_cell_cycle2.87683236
8MP0005174_abnormal_tail_pigmentation2.65736100
9MP0003195_calcinosis2.65027189
10MP0006292_abnormal_olfactory_placode2.61804152
11MP0008995_early_reproductive_senescence2.58787323
12MP0008007_abnormal_cellular_replicative2.40838180
13MP0002396_abnormal_hematopoietic_system2.40098333
14MP0000372_irregular_coat_pigmentation2.24668598
15MP0004957_abnormal_blastocyst_morpholog2.22441958
16MP0003718_maternal_effect2.19893539
17MP0003646_muscle_fatigue2.18771027
18MP0006072_abnormal_retinal_apoptosis2.16833951
19MP0005551_abnormal_eye_electrophysiolog2.15709597
20MP0001835_abnormal_antigen_presentation2.10481430
21MP0002837_dystrophic_cardiac_calcinosis2.10303124
22MP0000015_abnormal_ear_pigmentation2.06759052
23MP0001529_abnormal_vocalization2.05707963
24MP0005075_abnormal_melanosome_morpholog2.04092645
25MP0004142_abnormal_muscle_tone1.92507067
26MP0005084_abnormal_gallbladder_morpholo1.91552512
27MP0001986_abnormal_taste_sensitivity1.90705611
28MP0003787_abnormal_imprinting1.89470964
29MP0003941_abnormal_skin_development1.86301258
30MP0001188_hyperpigmentation1.80470178
31MP0004133_heterotaxia1.80417969
32MP0004808_abnormal_hematopoietic_stem1.77439621
33MP0005253_abnormal_eye_physiology1.76932974
34MP0002638_abnormal_pupillary_reflex1.76462509
35MP0004147_increased_porphyrin_level1.74602181
36MP0000490_abnormal_crypts_of1.74401108
37MP0000566_synostosis1.68041800
38MP0000631_abnormal_neuroendocrine_gland1.62846857
39MP0002277_abnormal_respiratory_mucosa1.61701458
40MP0002938_white_spotting1.60787008
41MP0003763_abnormal_thymus_physiology1.59601878
42MP0006276_abnormal_autonomic_nervous1.59389712
43MP0005671_abnormal_response_to1.58832853
44MP0002736_abnormal_nociception_after1.58636430
45MP0002102_abnormal_ear_morphology1.52834648
46MP0003786_premature_aging1.51916490
47MP0010307_abnormal_tumor_latency1.51483278
48MP0002095_abnormal_skin_pigmentation1.50806541
49MP0008875_abnormal_xenobiotic_pharmacok1.44227922
50MP0005646_abnormal_pituitary_gland1.43245622
51MP0009697_abnormal_copulation1.42796802
52MP0009046_muscle_twitch1.42066324
53MP0001800_abnormal_humoral_immune1.41698281
54MP0002876_abnormal_thyroid_physiology1.38374937
55MP0002398_abnormal_bone_marrow1.37473779
56MP0004381_abnormal_hair_follicle1.36983781
57MP0001968_abnormal_touch/_nociception1.35832968
58MP0002234_abnormal_pharynx_morphology1.35566990
59MP0008932_abnormal_embryonic_tissue1.34619148
60MP0008877_abnormal_DNA_methylation1.33024528
61MP0002452_abnormal_antigen_presenting1.32600068
62MP0001293_anophthalmia1.30395822
63MP0001764_abnormal_homeostasis1.28241799
64MP0002163_abnormal_gland_morphology1.27355542
65MP0008872_abnormal_physiological_respon1.26466383
66MP0000350_abnormal_cell_proliferation1.25125394
67MP0005645_abnormal_hypothalamus_physiol1.24265860
68MP0000703_abnormal_thymus_morphology1.22842135
69MP0000858_altered_metastatic_potential1.22132865
70MP0000371_diluted_coat_color1.19844802
71MP0002420_abnormal_adaptive_immunity1.19462033
72MP0001545_abnormal_hematopoietic_system1.19120820
73MP0005397_hematopoietic_system_phenotyp1.19120820
74MP0001819_abnormal_immune_cell1.18520922
75MP0001485_abnormal_pinna_reflex1.17480937
76MP0001790_abnormal_immune_system1.17413533
77MP0005387_immune_system_phenotype1.17413533
78MP0002148_abnormal_hypersensitivity_rea1.16438411
79MP0006035_abnormal_mitochondrial_morpho1.16065311
80MP0003890_abnormal_embryonic-extraembry1.15248404
81MP0004215_abnormal_myocardial_fiber1.14888157
82MP0009785_altered_susceptibility_to1.14492221
83MP0004145_abnormal_muscle_electrophysio1.14479041
84MP0002419_abnormal_innate_immunity1.14221737
85MP0003436_decreased_susceptibility_to1.13699205
86MP0002722_abnormal_immune_system1.13222231
87MP0000716_abnormal_immune_system1.13088619
88MP0002132_abnormal_respiratory_system1.11658377
89MP0002723_abnormal_immune_serum1.11529145
90MP0000689_abnormal_spleen_morphology1.11177866
91MP0008775_abnormal_heart_ventricle1.11066161
92MP0002075_abnormal_coat/hair_pigmentati1.10333530
93MP0005076_abnormal_cell_differentiation1.10259075
94MP0004043_abnormal_pH_regulation1.09850781
95MP0005377_hearing/vestibular/ear_phenot1.07820092
96MP0003878_abnormal_ear_physiology1.07820092
97MP0000685_abnormal_immune_system1.07626418
98MP0000427_abnormal_hair_cycle1.07439443
99MP0003567_abnormal_fetal_cardiomyocyte1.07310407
100MP0001984_abnormal_olfaction1.07268634
101MP0002019_abnormal_tumor_incidence1.05960902
102MP0002751_abnormal_autonomic_nervous1.05776134
103MP0001929_abnormal_gametogenesis1.04807500
104MP0003806_abnormal_nucleotide_metabolis1.04796767
105MP0010352_gastrointestinal_tract_polyps1.04580396
106MP0000313_abnormal_cell_death1.04057899
107MP0005000_abnormal_immune_tolerance1.03698748
108MP0003937_abnormal_limbs/digits/tail_de1.02902490
109MP0003186_abnormal_redox_activity1.02412178
110MP0005257_abnormal_intraocular_pressure1.02016817
111MP0001186_pigmentation_phenotype1.01738050
112MP0002429_abnormal_blood_cell1.00832545
113MP0006036_abnormal_mitochondrial_physio1.00408826
114MP0005195_abnormal_posterior_eye1.00069289
115MP0005389_reproductive_system_phenotype0.99671634
116MP0002006_tumorigenesis0.99574040
117MP0005025_abnormal_response_to0.99434313
118MP0001919_abnormal_reproductive_system0.97873040
119MP0009333_abnormal_splenocyte_physiolog0.97364106
120MP0000653_abnormal_sex_gland0.95847561
121MP0001324_abnormal_eye_pigmentation0.94410702
122MP0003136_yellow_coat_color0.94143712
123MP0000383_abnormal_hair_follicle0.93786609
124MP0003283_abnormal_digestive_organ0.93579687
125MP0001145_abnormal_male_reproductive0.91603344
126MP0003121_genomic_imprinting0.89943697
127MP0004742_abnormal_vestibular_system0.88326257
128MP0003880_abnormal_central_pattern0.87319338
129MP0005409_darkened_coat_color0.86914496
130MP0009278_abnormal_bone_marrow0.86738089
131MP0005380_embryogenesis_phenotype0.86107117
132MP0001672_abnormal_embryogenesis/_devel0.86107117
133MP0003172_abnormal_lysosome_physiology0.86050874
134MP0005332_abnormal_amino_acid0.86005257
135MP0002928_abnormal_bile_duct0.84932040
136MP0002405_respiratory_system_inflammati0.83797955
137MP0005464_abnormal_platelet_physiology0.83702314
138MP0003698_abnormal_male_reproductive0.83458490
139MP0000647_abnormal_sebaceous_gland0.83183787
140MP0005394_taste/olfaction_phenotype0.82444656
141MP0005499_abnormal_olfactory_system0.82444656
142MP0005379_endocrine/exocrine_gland_phen0.82382780
143MP0005408_hypopigmentation0.82023587
144MP0002272_abnormal_nervous_system0.81730296
145MP0005391_vision/eye_phenotype0.80507858
146MP0001119_abnormal_female_reproductive0.80221401
147MP0005395_other_phenotype0.79563278
148MP0002160_abnormal_reproductive_system0.78894389
149MP0008789_abnormal_olfactory_epithelium0.78674979
150MP0003119_abnormal_digestive_system0.78319876
151MP0002166_altered_tumor_susceptibility0.78187748
152MP0002653_abnormal_ependyma_morphology0.77928122
153MP0008260_abnormal_autophagy0.76852452
154MP0003943_abnormal_hepatobiliary_system0.76749519
155MP0001873_stomach_inflammation0.76227655
156MP0002138_abnormal_hepatobiliary_system0.76043582
157MP0002233_abnormal_nose_morphology0.75142642
158MP0002177_abnormal_outer_ear0.74959880
159MP0000049_abnormal_middle_ear0.74511455
160MP0004197_abnormal_fetal_growth/weight/0.74345973
161MP0010155_abnormal_intestine_physiology0.73629527
162MP0002085_abnormal_embryonic_tissue0.71129309
163MP0001286_abnormal_eye_development0.70520169
164MP0001697_abnormal_embryo_size0.70467161
165MP0002210_abnormal_sex_determination0.69742806
166MP0001730_embryonic_growth_arrest0.69551715
167MP0002088_abnormal_embryonic_growth/wei0.69262663

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.61099720
2Chromsome breakage (HP:0040012)5.43695457
3Pancreatic cysts (HP:0001737)3.96043408
4Abnormality of midbrain morphology (HP:0002418)3.74755946
5Molar tooth sign on MRI (HP:0002419)3.74755946
6Pancreatic fibrosis (HP:0100732)3.50975572
7Abnormality of the preputium (HP:0100587)3.41084087
8Abnormality of chromosome stability (HP:0003220)3.34929012
9Nephronophthisis (HP:0000090)3.29806051
10Abnormality of the renal collecting system (HP:0004742)3.28003656
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.25341453
12Reticulocytopenia (HP:0001896)3.16432402
13Acute necrotizing encephalopathy (HP:0006965)3.11294652
14Meckel diverticulum (HP:0002245)3.10534338
15Increased CSF lactate (HP:0002490)3.09798714
16Congenital stationary night blindness (HP:0007642)3.05797639
17Abnormality of DNA repair (HP:0003254)3.05345414
18Abnormality of the fingertips (HP:0001211)3.05099312
19Mitochondrial inheritance (HP:0001427)3.03798438
20Myelodysplasia (HP:0002863)3.03463950
21Type II lissencephaly (HP:0007260)3.01115647
22Abnormality of the labia minora (HP:0012880)3.01054318
23Hypoplasia of the pons (HP:0012110)3.00496578
24Volvulus (HP:0002580)2.99880498
25Abnormality of the ileum (HP:0001549)2.99000375
26Ectopic kidney (HP:0000086)2.98273960
27Duplicated collecting system (HP:0000081)2.97665823
28Abnormality of the pons (HP:0007361)2.97279070
29Acute encephalopathy (HP:0006846)2.91334614
30Medial flaring of the eyebrow (HP:0010747)2.78627882
31Hepatocellular necrosis (HP:0001404)2.77680940
32Clubbing of toes (HP:0100760)2.76031691
33Increased hepatocellular lipid droplets (HP:0006565)2.74541468
34Lip pit (HP:0100267)2.71874565
35Abnormality of alanine metabolism (HP:0010916)2.70769763
36Hyperalaninemia (HP:0003348)2.70769763
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70769763
38Abnormal mitochondria in muscle tissue (HP:0008316)2.68259786
39Progressive macrocephaly (HP:0004481)2.63703976
40Lipid accumulation in hepatocytes (HP:0006561)2.63079961
41Thyroid-stimulating hormone excess (HP:0002925)2.62660825
42Abnormality of the renal medulla (HP:0100957)2.60598694
43Chronic hepatic failure (HP:0100626)2.56147563
44Nephroblastoma (Wilms tumor) (HP:0002667)2.54208907
45Acute lymphatic leukemia (HP:0006721)2.52136062
46Hepatic necrosis (HP:0002605)2.51983480
47Pendular nystagmus (HP:0012043)2.51612869
48Bone marrow hypocellularity (HP:0005528)2.44713052
49Recurrent abscess formation (HP:0002722)2.41673565
50Acute myeloid leukemia (HP:0004808)2.41524412
51Abnormality of the renal cortex (HP:0011035)2.40380639
52Duodenal stenosis (HP:0100867)2.40053272
53Small intestinal stenosis (HP:0012848)2.40053272
54Agnosia (HP:0010524)2.39939248
55Cerebellar dysplasia (HP:0007033)2.38591608
56Sclerocornea (HP:0000647)2.37796159
57Methylmalonic acidemia (HP:0002912)2.36408126
58Birth length less than 3rd percentile (HP:0003561)2.35004180
59Increased serum lactate (HP:0002151)2.32732106
60Attenuation of retinal blood vessels (HP:0007843)2.32685493
61Embryonal renal neoplasm (HP:0011794)2.31429324
62Optic nerve coloboma (HP:0000588)2.29215409
63Abnormality of the carotid arteries (HP:0005344)2.27617399
64Long eyelashes (HP:0000527)2.22096727
65Medulloblastoma (HP:0002885)2.19686108
66Renal cortical cysts (HP:0000803)2.16012165
673-Methylglutaconic aciduria (HP:0003535)2.15935936
68Sloping forehead (HP:0000340)2.14174033
69Absent thumb (HP:0009777)2.13757706
70Prominent nose (HP:0000448)2.13634946
71Congenital primary aphakia (HP:0007707)2.12771314
7211 pairs of ribs (HP:0000878)2.12015852
73Optic disc pallor (HP:0000543)2.11909890
74Abolished electroretinogram (ERG) (HP:0000550)2.11688835
75Recurrent bacterial skin infections (HP:0005406)2.10674367
76Pallor (HP:0000980)2.10424854
77Optic nerve hypoplasia (HP:0000609)2.10253578
78Aplastic anemia (HP:0001915)2.09580949
79Cystic liver disease (HP:0006706)2.09447991
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.09345282
81Amaurosis fugax (HP:0100576)2.08973498
82Recurrent viral infections (HP:0004429)2.08754766
83Type I transferrin isoform profile (HP:0003642)2.07897489
84Nephrogenic diabetes insipidus (HP:0009806)2.06373334
85Recurrent fungal infections (HP:0002841)2.05593959
86Obstructive lung disease (HP:0006536)2.05582080
87Chronic obstructive pulmonary disease (HP:0006510)2.05582080
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05200685
89Leukopenia (HP:0001882)2.04640622
90Gait imbalance (HP:0002141)2.04192455
91Abnormality of the duodenum (HP:0002246)2.03797472
92Hyperglycinemia (HP:0002154)2.02185656
93Abnormal biliary tract physiology (HP:0012439)2.00940096
94Bile duct proliferation (HP:0001408)2.00940096
95Ependymoma (HP:0002888)2.00378151
96IgM deficiency (HP:0002850)2.00216131
97Anencephaly (HP:0002323)2.00017619
98Spinal cord lesions (HP:0100561)1.96486449
99Syringomyelia (HP:0003396)1.96486449
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.96194661
101Hypoplasia of the fovea (HP:0007750)1.96194661
102Lissencephaly (HP:0001339)1.95900064
103Methylmalonic aciduria (HP:0012120)1.95644654
104Congenital hepatic fibrosis (HP:0002612)1.95085782
105Lactic acidosis (HP:0003128)1.92933106
106Increased serum pyruvate (HP:0003542)1.91467553
107Lymphoma (HP:0002665)1.91078961
108Inability to walk (HP:0002540)1.90486957
109Cerebral edema (HP:0002181)1.89640499
110Dandy-Walker malformation (HP:0001305)1.89499314
111Abnormal protein glycosylation (HP:0012346)1.89487208
112Abnormal glycosylation (HP:0012345)1.89487208
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89487208
114Abnormal protein N-linked glycosylation (HP:0012347)1.89487208
115Postaxial foot polydactyly (HP:0001830)1.88705658
116Periodontitis (HP:0000704)1.86844618
117Male pseudohermaphroditism (HP:0000037)1.84152054
118Tubular atrophy (HP:0000092)1.83084266
119Progressive inability to walk (HP:0002505)1.83081811
120Triphalangeal thumb (HP:0001199)1.82830330
121Renal Fanconi syndrome (HP:0001994)1.82807544
122Thrombocytosis (HP:0001894)1.82800591
123Patellar aplasia (HP:0006443)1.82448294
124Furrowed tongue (HP:0000221)1.81955654
125Astigmatism (HP:0000483)1.80838004
126Prostate neoplasm (HP:0100787)1.80541498
127Mediastinal lymphadenopathy (HP:0100721)1.78903469
128Retinal dysplasia (HP:0007973)1.78139015
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77877119
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.77607529
131Panhypogammaglobulinemia (HP:0003139)1.77276936
132Abnormality of the columella (HP:0009929)1.77272780
133Short thumb (HP:0009778)1.77226487
134Reduced antithrombin III activity (HP:0001976)1.77099292
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77026545
136Septo-optic dysplasia (HP:0100842)1.76574458
137Constricted visual fields (HP:0001133)1.76003638
138Impulsivity (HP:0100710)1.75919469
139Hyperventilation (HP:0002883)1.75175229
140Abnormality of glycolysis (HP:0004366)1.74848075
141Small hand (HP:0200055)1.74234560
142Supernumerary spleens (HP:0009799)1.73790858
143Chronic otitis media (HP:0000389)1.73311799
144Eczematoid dermatitis (HP:0000976)1.72537726
145Intestinal atresia (HP:0011100)1.71823290
146Abnormal lung lobation (HP:0002101)1.71639727
147Genital tract atresia (HP:0001827)1.70951978
148Premature graying of hair (HP:0002216)1.70641928
149Absent radius (HP:0003974)1.68531845
150Abnormal rod and cone electroretinograms (HP:0008323)1.68469419
151Aplasia/Hypoplasia of the patella (HP:0006498)1.67748329
152Vaginal atresia (HP:0000148)1.67659842
153True hermaphroditism (HP:0010459)1.67263830
154CNS demyelination (HP:0007305)1.66361446
155Gastrointestinal atresia (HP:0002589)1.66083330
156Degeneration of anterior horn cells (HP:0002398)1.65320986
157Abnormality of the anterior horn cell (HP:0006802)1.65320986
158Tracheoesophageal fistula (HP:0002575)1.64834702
159Recurrent cutaneous fungal infections (HP:0011370)1.63283047
160Chronic mucocutaneous candidiasis (HP:0002728)1.63283047
161Abnormality of the prostate (HP:0008775)1.62015541
162Microvesicular hepatic steatosis (HP:0001414)1.61797434
163Duplication of thumb phalanx (HP:0009942)1.59748574
164Cellular immunodeficiency (HP:0005374)1.58797567
165Recurrent pneumonia (HP:0006532)1.58296075
166Meningitis (HP:0001287)1.57475558
167Aplasia cutis congenita (HP:0001057)1.57129321
168Colon cancer (HP:0003003)1.56188297
169IgG deficiency (HP:0004315)1.55404832
170Blepharitis (HP:0000498)1.52518771
171Prolonged bleeding time (HP:0003010)1.52465916
172Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51915525
173Absent epiphyses (HP:0010577)1.51915525
174Abnormality of the nasal septum (HP:0000419)1.51217735
175Pancytopenia (HP:0001876)1.50451539
176Abnormality of the intervertebral disk (HP:0005108)1.50304286
177Encephalitis (HP:0002383)1.50229465
178Cafe-au-lait spot (HP:0000957)1.50136712
179Embryonal neoplasm (HP:0002898)1.50003077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.25180740
2MKNK23.22437507
3MAP4K23.05211438
4ZAK2.71717591
5CDC72.69141401
6MKNK12.66156832
7WNK32.65205629
8MST42.49349873
9PBK2.48484752
10SRPK12.40669072
11WEE12.30440920
12PLK42.30208067
13BUB12.25037927
14NEK22.18735429
15MAP3K142.00998733
16VRK11.99086290
17IRAK41.97621940
18TXK1.95076426
19ATR1.89088325
20BRD41.88463486
21TRIM281.86457369
22NEK11.86089689
23RPS6KA41.83410644
24STK161.81951371
25VRK21.81843508
26IRAK31.80612194
27CDK121.80167370
28YES11.75757010
29ACVR1B1.74206750
30TTK1.68386211
31EIF2AK21.68004808
32TAF11.57652510
33KIT1.53610442
34MAP4K11.51432370
35CDK71.48306655
36BCR1.48223601
37PDK21.47752582
38DYRK21.47133276
39TEC1.46738734
40JAK31.40789506
41BRSK21.40144612
42CHEK21.35929221
43PNCK1.35914127
44MAP3K41.34863475
45PINK11.34527777
46TNIK1.34407172
47TLK11.31599075
48AURKB1.30849321
49FLT31.29074756
50PLK31.27297998
51PLK11.25584703
52PASK1.23683268
53TAOK31.18696802
54MAPK131.17856759
55NME11.16493874
56PLK21.13517955
57CDK41.13390862
58WNK41.11960182
59EIF2AK31.07523245
60ERBB31.07485379
61DYRK31.05656627
62IKBKB1.04841497
63CHUK1.04659317
64OXSR11.04124124
65CHEK11.03047426
66ATM1.01680568
67STK38L0.99132189
68INSRR0.98420104
69BCKDK0.98361100
70CASK0.98150647
71BTK0.98120096
72MAP2K70.97172772
73STK40.97006281
74MAP2K60.94970690
75PIM10.93198270
76MUSK0.89090478
77OBSCN0.87678969
78RPS6KB20.84659362
79STK390.84146017
80STK100.83844999
81CSNK1A1L0.82716925
82EIF2AK10.82282812
83TIE10.81247317
84TSSK60.80539157
85ADRBK20.80490738
86EPHA20.80408760
87CSNK1G10.79684165
88AKT30.79566791
89CAMK1D0.76975416
90BMPR1B0.75361565
91AURKA0.72332719
92CDK30.71179062
93MARK30.70917159
94CSNK1G30.70711827
95LYN0.69948018
96DAPK20.69845321
97CCNB10.69798208
98CDK60.69654618
99CLK10.69614984
100CDK80.68583733
101CSNK1G20.67850086
102SYK0.67576124
103PAK30.67338636
104RPS6KA50.67145883
105NUAK10.66703451
106IKBKE0.65296919
107CDK20.63867323
108PRKCE0.63762641
109LCK0.63618844
110NEK60.63186947
111STK30.61581838
112TGFBR10.61195431
113BRSK10.59666433
114ADRBK10.59619655
115NEK90.59482073
116NLK0.57597037
117GRK10.56266998
118BLK0.56167926
119CDK10.56014970
120ITK0.52533850
121TRPM70.51364778
122TYK20.51225978
123PRKCG0.51090559
124STK240.50516618
125MAP3K80.50149636
126CAMK1G0.49939793
127MAP3K60.49193059
128PHKG10.48730325
129PHKG20.48730325
130HIPK20.46933648
131CDK190.45984535
132HCK0.45924338
133CSF1R0.45739709
134TAOK20.45226731
135RPS6KB10.44461809
136SIK30.43656667
137SGK20.42112918
138CSNK2A10.42041646
139MAP2K30.42026602
140PIK3CG0.41071474
141MELK0.39913467
142ZAP700.38193591
143EPHA30.38067722
144PRKCI0.35858288
145CSNK1A10.34038936
146CSNK1E0.33996653
147CAMKK20.33879372
148PRKCQ0.31614032
149CSNK2A20.30325901
150MAPK150.30148655
151MAP3K50.29798214
152PRKACA0.25701716
153ERBB40.25396616

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.53668904
2Mismatch repair_Homo sapiens_hsa034303.34928192
3Homologous recombination_Homo sapiens_hsa034403.12419749
4Fanconi anemia pathway_Homo sapiens_hsa034603.01521231
5Oxidative phosphorylation_Homo sapiens_hsa001902.89035929
6Base excision repair_Homo sapiens_hsa034102.73268443
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54390363
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37947466
9One carbon pool by folate_Homo sapiens_hsa006702.33037719
10Cell cycle_Homo sapiens_hsa041102.28897694
11Parkinsons disease_Homo sapiens_hsa050122.26144094
12Spliceosome_Homo sapiens_hsa030402.22606211
13Non-homologous end-joining_Homo sapiens_hsa034502.21153856
14Nucleotide excision repair_Homo sapiens_hsa034202.10281270
15Propanoate metabolism_Homo sapiens_hsa006402.10235043
16RNA polymerase_Homo sapiens_hsa030202.09215197
17RNA transport_Homo sapiens_hsa030132.06218794
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99767458
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90190533
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78882115
21Huntingtons disease_Homo sapiens_hsa050161.74298969
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.74283399
23Ribosome_Homo sapiens_hsa030101.71546207
24Butanoate metabolism_Homo sapiens_hsa006501.71424570
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70205515
26Pyrimidine metabolism_Homo sapiens_hsa002401.64207206
27Herpes simplex infection_Homo sapiens_hsa051681.63267249
28RNA degradation_Homo sapiens_hsa030181.62975195
29Basal transcription factors_Homo sapiens_hsa030221.61420641
30p53 signaling pathway_Homo sapiens_hsa041151.59065633
31Primary immunodeficiency_Homo sapiens_hsa053401.52370244
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47274151
33Allograft rejection_Homo sapiens_hsa053301.43776739
34mRNA surveillance pathway_Homo sapiens_hsa030151.41799876
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40232880
36Alzheimers disease_Homo sapiens_hsa050101.37764058
37Measles_Homo sapiens_hsa051621.37336449
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35921511
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.32192682
40Steroid biosynthesis_Homo sapiens_hsa001001.31706093
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29629375
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29410390
43Phototransduction_Homo sapiens_hsa047441.27070502
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24401183
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23296790
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21796744
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21204078
48Hematopoietic cell lineage_Homo sapiens_hsa046401.19221949
49Linoleic acid metabolism_Homo sapiens_hsa005911.19145271
50Leishmaniasis_Homo sapiens_hsa051401.16923446
51Nitrogen metabolism_Homo sapiens_hsa009101.16869067
52Systemic lupus erythematosus_Homo sapiens_hsa053221.15926361
53Graft-versus-host disease_Homo sapiens_hsa053321.15766513
54Antigen processing and presentation_Homo sapiens_hsa046121.14607529
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.13689338
56Epstein-Barr virus infection_Homo sapiens_hsa051691.12905033
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11796997
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10051806
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08920837
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.07876616
61Tryptophan metabolism_Homo sapiens_hsa003801.07647880
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07057112
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05838200
64Ether lipid metabolism_Homo sapiens_hsa005651.05447122
65Cardiac muscle contraction_Homo sapiens_hsa042601.04948409
66Nicotine addiction_Homo sapiens_hsa050331.04541716
67Caffeine metabolism_Homo sapiens_hsa002321.03881175
68Influenza A_Homo sapiens_hsa051640.99687664
69Proteasome_Homo sapiens_hsa030500.99479909
70Peroxisome_Homo sapiens_hsa041460.99398446
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.98581169
72Autoimmune thyroid disease_Homo sapiens_hsa053200.98441095
73Viral carcinogenesis_Homo sapiens_hsa052030.97898669
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96511143
75Regulation of autophagy_Homo sapiens_hsa041400.95926914
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94102969
77Purine metabolism_Homo sapiens_hsa002300.93982766
78Legionellosis_Homo sapiens_hsa051340.92879388
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92485669
80Pyruvate metabolism_Homo sapiens_hsa006200.92072780
81Asthma_Homo sapiens_hsa053100.90035086
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89449907
83MicroRNAs in cancer_Homo sapiens_hsa052060.86755108
84HTLV-I infection_Homo sapiens_hsa051660.84288180
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84086992
86Apoptosis_Homo sapiens_hsa042100.82061933
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81964042
88Lysine degradation_Homo sapiens_hsa003100.80081262
89B cell receptor signaling pathway_Homo sapiens_hsa046620.79836735
90Metabolic pathways_Homo sapiens_hsa011000.79697083
91TNF signaling pathway_Homo sapiens_hsa046680.77517286
92Olfactory transduction_Homo sapiens_hsa047400.74770540
93Hepatitis B_Homo sapiens_hsa051610.74165438
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.74033361
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73246467
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72620161
97Small cell lung cancer_Homo sapiens_hsa052220.72612777
98Circadian rhythm_Homo sapiens_hsa047100.70074344
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69660628
100Osteoclast differentiation_Homo sapiens_hsa043800.69006487
101Type I diabetes mellitus_Homo sapiens_hsa049400.67869370
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67346068
103Taste transduction_Homo sapiens_hsa047420.66786951
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.66268514
105Acute myeloid leukemia_Homo sapiens_hsa052210.63442693
106T cell receptor signaling pathway_Homo sapiens_hsa046600.62330471
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58535271
108Collecting duct acid secretion_Homo sapiens_hsa049660.58372788
109Tuberculosis_Homo sapiens_hsa051520.58316714
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.58190012
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58012000
112Fatty acid elongation_Homo sapiens_hsa000620.57718842
113Malaria_Homo sapiens_hsa051440.57297154
114Vitamin digestion and absorption_Homo sapiens_hsa049770.56990068
115Sulfur metabolism_Homo sapiens_hsa009200.56042502
116Notch signaling pathway_Homo sapiens_hsa043300.55165179
117Chemical carcinogenesis_Homo sapiens_hsa052040.54890356
118Retinol metabolism_Homo sapiens_hsa008300.53958599
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53672959
120Viral myocarditis_Homo sapiens_hsa054160.52896178
121Protein export_Homo sapiens_hsa030600.52730973
122Fatty acid metabolism_Homo sapiens_hsa012120.52633587
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52289735
124Shigellosis_Homo sapiens_hsa051310.51459099
125Selenocompound metabolism_Homo sapiens_hsa004500.50989692
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50728641
127Thyroid cancer_Homo sapiens_hsa052160.50586429
128Sphingolipid metabolism_Homo sapiens_hsa006000.49463927
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47714012
130ABC transporters_Homo sapiens_hsa020100.43409048
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42720531
132Chronic myeloid leukemia_Homo sapiens_hsa052200.42529695
133Glycerolipid metabolism_Homo sapiens_hsa005610.42053276
134Glutathione metabolism_Homo sapiens_hsa004800.41947896
135Other glycan degradation_Homo sapiens_hsa005110.40958351
136FoxO signaling pathway_Homo sapiens_hsa040680.40729534
137Pathways in cancer_Homo sapiens_hsa052000.40451493
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40149718
139Pertussis_Homo sapiens_hsa051330.38976782
140Prostate cancer_Homo sapiens_hsa052150.38543975
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38520325
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38232660
143beta-Alanine metabolism_Homo sapiens_hsa004100.37671846
144Fatty acid degradation_Homo sapiens_hsa000710.37528411
145Toxoplasmosis_Homo sapiens_hsa051450.37457670
146GABAergic synapse_Homo sapiens_hsa047270.37169068
147Hepatitis C_Homo sapiens_hsa051600.36303102
148Chemokine signaling pathway_Homo sapiens_hsa040620.35814688
149Fat digestion and absorption_Homo sapiens_hsa049750.34561993
150Alcoholism_Homo sapiens_hsa050340.33459689
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33041793
152Arachidonic acid metabolism_Homo sapiens_hsa005900.32991518
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32663925
154Basal cell carcinoma_Homo sapiens_hsa052170.32181574
155Folate biosynthesis_Homo sapiens_hsa007900.31047786
156Morphine addiction_Homo sapiens_hsa050320.29928255
157Colorectal cancer_Homo sapiens_hsa052100.29499543
158Inositol phosphate metabolism_Homo sapiens_hsa005620.29384276
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28448479
160Oocyte meiosis_Homo sapiens_hsa041140.28411477
161Melanoma_Homo sapiens_hsa052180.27389762
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26400611
163Sulfur relay system_Homo sapiens_hsa041220.23986959
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23418802
1652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21648900
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20791177

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