ZCCHC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.83786950
2bone trabecula formation (GO:0060346)7.55034061
3chondrocyte development (GO:0002063)6.95918000
4protein heterotrimerization (GO:0070208)6.73101161
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.12358619
6positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.41672201
7keratan sulfate catabolic process (GO:0042340)5.26952504
8collagen metabolic process (GO:0032963)5.25254014
9collagen catabolic process (GO:0030574)5.25129216
10sequestering of extracellular ligand from receptor (GO:0035581)5.23103588
11chondrocyte proliferation (GO:0035988)5.07948257
12multicellular organismal macromolecule metabolic process (GO:0044259)4.91356548
13multicellular organismal catabolic process (GO:0044243)4.80031589
14cell adhesion mediated by integrin (GO:0033627)4.76932497
15multicellular organismal metabolic process (GO:0044236)4.64039428
16Golgi transport vesicle coating (GO:0048200)4.51908954
17COPI coating of Golgi vesicle (GO:0048205)4.51908954
18skin morphogenesis (GO:0043589)4.51056934
19axon extension involved in axon guidance (GO:0048846)4.49367466
20neuron projection extension involved in neuron projection guidance (GO:1902284)4.49367466
21insulin-like growth factor receptor signaling pathway (GO:0048009)4.40363143
22regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.36909175
23stress fiber assembly (GO:0043149)4.36322167
24endodermal cell differentiation (GO:0035987)4.32289590
25negative regulation of chondrocyte differentiation (GO:0032331)4.31184361
26planar cell polarity pathway involved in neural tube closure (GO:0090179)4.29963005
27positive regulation of glycogen biosynthetic process (GO:0045725)4.28344802
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.23877565
29extracellular matrix disassembly (GO:0022617)4.23227190
30dermatan sulfate biosynthetic process (GO:0030208)4.19675829
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.16951274
32extracellular fibril organization (GO:0043206)4.15091379
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.14169060
34cellular response to vitamin (GO:0071295)4.11944238
35hyaluronan catabolic process (GO:0030214)4.04184490
36actin filament depolymerization (GO:0030042)4.01740197
37craniofacial suture morphogenesis (GO:0097094)3.93326042
38exocrine pancreas development (GO:0031017)3.90739468
39negative regulation of fatty acid transport (GO:2000192)3.90070946
40negative regulation of smooth muscle cell migration (GO:0014912)3.87837859
41regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.87829957
42adhesion of symbiont to host cell (GO:0044650)3.87515041
43virion attachment to host cell (GO:0019062)3.87515041
44cell aggregation (GO:0098743)3.84346966
45cartilage condensation (GO:0001502)3.84346966
46COPII vesicle coating (GO:0048208)3.83323762
47embryonic cranial skeleton morphogenesis (GO:0048701)3.82159291
48positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.81104694
49dermatan sulfate metabolic process (GO:0030205)3.80815709
50positive regulation of insulin receptor signaling pathway (GO:0046628)3.77127230
51peptidyl-proline hydroxylation (GO:0019511)3.75191416
52glucosamine-containing compound catabolic process (GO:1901072)3.71436700
53wound healing, spreading of epidermal cells (GO:0035313)3.70848666
54extracellular negative regulation of signal transduction (GO:1900116)3.70005658
55extracellular regulation of signal transduction (GO:1900115)3.70005658
56membrane raft organization (GO:0031579)3.69874599
57positive regulation of mesenchymal cell proliferation (GO:0002053)3.69539513
58response to gravity (GO:0009629)3.68778603
59negative regulation of cartilage development (GO:0061037)3.68531058
60embryonic skeletal joint morphogenesis (GO:0060272)3.66210155
61hippo signaling (GO:0035329)3.64996579
62positive regulation of blood vessel endothelial cell migration (GO:0043536)3.62919433
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62600018
64regulation of chondrocyte differentiation (GO:0032330)3.61380977
65positive regulation of glycogen metabolic process (GO:0070875)3.60578640
66cellular response to vitamin D (GO:0071305)3.59539215
67cell proliferation involved in metanephros development (GO:0072203)3.57624677
68fibril organization (GO:0097435)3.54133118
69middle ear morphogenesis (GO:0042474)3.53718597
70response to magnesium ion (GO:0032026)3.51632406
71regulation of cartilage development (GO:0061035)3.47047889
72negative regulation of nitric-oxide synthase activity (GO:0051001)3.46677913
73cartilage development (GO:0051216)3.46279105
74camera-type eye morphogenesis (GO:0048593)3.44617747
75outer ear morphogenesis (GO:0042473)3.43984081
76cell migration involved in heart development (GO:0060973)3.43073384
77notochord development (GO:0030903)3.41860176
78regulation of mesenchymal cell proliferation (GO:0010464)3.39431892
79positive regulation of cartilage development (GO:0061036)3.38455567
80positive regulation of chondrocyte differentiation (GO:0032332)3.38018393
81regulation of macrophage cytokine production (GO:0010935)3.37927944
82heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.37026804
83wound healing, spreading of cells (GO:0044319)3.34493473
84substrate-dependent cell migration (GO:0006929)3.33068861
85anatomical structure regression (GO:0060033)3.31652401
86sprouting angiogenesis (GO:0002040)3.31217114
87protein hydroxylation (GO:0018126)3.31115838
88regulation of non-canonical Wnt signaling pathway (GO:2000050)3.30077873
89venous blood vessel morphogenesis (GO:0048845)3.29675526
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.29628034
91glial cell migration (GO:0008347)3.29555445
92chondrocyte differentiation (GO:0002062)3.28680798
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.27804859
94cell-substrate junction assembly (GO:0007044)3.27364874
95protein localization to endosome (GO:0036010)3.26915181
96cranial suture morphogenesis (GO:0060363)3.26341867
97hypotonic response (GO:0006971)3.26341080
98endothelial cell morphogenesis (GO:0001886)3.26133264
99adhesion of symbiont to host (GO:0044406)3.26106275
100metanephric mesenchyme development (GO:0072075)3.25638674
101positive regulation of hormone biosynthetic process (GO:0046886)3.25261095
102positive regulation of extracellular matrix organization (GO:1903055)3.25189069
103regulation of establishment of planar polarity (GO:0090175)3.24326333
104negative regulation of catenin import into nucleus (GO:0035414)3.23532839
105glomerular filtration (GO:0003094)3.20218533
106trabecula formation (GO:0060343)3.19850720
107chondroitin sulfate biosynthetic process (GO:0030206)3.19114870
108platelet aggregation (GO:0070527)3.19105076
109basement membrane organization (GO:0071711)3.17841390
110extracellular matrix organization (GO:0030198)3.16955568
111negative regulation of homotypic cell-cell adhesion (GO:0034111)3.16915050
112heart morphogenesis (GO:0003007)3.16744447
113extracellular structure organization (GO:0043062)3.15689336
114head development (GO:0060322)3.15159921
115replacement ossification (GO:0036075)3.14708213
116endochondral ossification (GO:0001958)3.14708213
117body morphogenesis (GO:0010171)3.13251198
118monocyte differentiation (GO:0030224)3.13040950
119type B pancreatic cell proliferation (GO:0044342)3.12531376
120regulation of extracellular matrix disassembly (GO:0010715)3.11750006
121bone morphogenesis (GO:0060349)3.10465009
122negative regulation of biomineral tissue development (GO:0070168)3.09682713
123response to increased oxygen levels (GO:0036296)3.09181160
124response to hyperoxia (GO:0055093)3.09181160
125apoptotic cell clearance (GO:0043277)3.07712273
126regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.07699651
127convergent extension (GO:0060026)3.06611984
128regulation of heart morphogenesis (GO:2000826)3.06317215
129cell wall macromolecule catabolic process (GO:0016998)3.06253646
130protein retention in ER lumen (GO:0006621)3.05952660
131positive regulation of epithelial to mesenchymal transition (GO:0010718)3.05911674
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04543406
133prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.04053077
134positive regulation of smoothened signaling pathway (GO:0045880)3.03488204
135cortical actin cytoskeleton organization (GO:0030866)3.03127159
136kidney mesenchyme development (GO:0072074)3.02610953
137pinocytosis (GO:0006907)3.02346216
138extracellular matrix assembly (GO:0085029)3.02209043
139cochlea morphogenesis (GO:0090103)3.01332956
140negative regulation of embryonic development (GO:0045992)2.97296499
141lateral sprouting from an epithelium (GO:0060601)2.96562344
142positive regulation of endothelial cell apoptotic process (GO:2000353)2.96388313
143mesenchymal-epithelial cell signaling (GO:0060638)2.96380575
144regulation of glycogen biosynthetic process (GO:0005979)2.95064029
145regulation of glucan biosynthetic process (GO:0010962)2.95064029
146negative regulation of glycogen biosynthetic process (GO:0045719)2.93363782
147positive regulation of catenin import into nucleus (GO:0035413)2.93243832
148platelet degranulation (GO:0002576)2.92735699
149cortical cytoskeleton organization (GO:0030865)2.92102083
150positive regulation of stem cell differentiation (GO:2000738)2.91420645
151paraxial mesoderm development (GO:0048339)2.91330656
152regulation of transforming growth factor beta2 production (GO:0032909)2.89751740
153negative regulation of osteoblast proliferation (GO:0033689)2.88190568
154vascular endothelial growth factor signaling pathway (GO:0038084)2.87321383
155negative regulation of skeletal muscle tissue development (GO:0048642)2.86889141
156retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86863541
157regulation of integrin-mediated signaling pathway (GO:2001044)2.84018392
158vesicle coating (GO:0006901)2.83606620
159cell-substrate adherens junction assembly (GO:0007045)2.73969367
160focal adhesion assembly (GO:0048041)2.73969367
161positive regulation of axon extension (GO:0045773)2.72672970
162pericardium development (GO:0060039)2.72580656
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71772367
164substrate adhesion-dependent cell spreading (GO:0034446)2.71538166
165endocardial cushion development (GO:0003197)2.69545418
166cell migration involved in sprouting angiogenesis (GO:0002042)2.67997083
167positive regulation of osteoblast proliferation (GO:0033690)2.67350106
168embryonic viscerocranium morphogenesis (GO:0048703)2.66611911
169amino sugar catabolic process (GO:0046348)2.65076097
170positive regulation of fibroblast migration (GO:0010763)2.64303578
171negative regulation of bone mineralization (GO:0030502)2.62465469
172positive regulation of endothelial cell migration (GO:0010595)2.62405957
173muscle cell migration (GO:0014812)2.62170405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.17428632
2E2F7_22180533_ChIP-Seq_HELA_Human4.28228952
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.14889250
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28972848
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07311028
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.76127847
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.74717183
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.70349644
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60477606
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41006901
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41006901
12AR_21572438_ChIP-Seq_LNCaP_Human2.40641912
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39007355
14EZH2_22144423_ChIP-Seq_EOC_Human2.38020668
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35176990
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32744170
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30355675
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.29895367
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.24130856
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.21077307
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.17804382
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16993091
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16546387
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06462234
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05517317
26TP53_22127205_ChIP-Seq_IMR90_Human2.03646505
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01700511
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00305171
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.99703503
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95758906
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.94950261
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93773792
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93078089
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.93011696
35JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92639858
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91535754
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91191686
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91007395
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91007395
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88451044
41CJUN_26792858_Chip-Seq_BT549_Human1.86489054
42* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85292923
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.84283560
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83501800
45BRD4_25478319_ChIP-Seq_HGPS_Human1.79947661
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78224556
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.77709559
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76241555
49TP53_18474530_ChIP-ChIP_U2OS_Human1.73522997
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73136172
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72228205
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68783756
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.66666278
54AR_21909140_ChIP-Seq_LNCAP_Human1.64270308
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63813933
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58954677
57NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.57218960
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.57009287
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56911042
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56283106
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56026868
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.52530724
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52058042
64VDR_24787735_ChIP-Seq_THP-1_Human1.49510498
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48762280
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48591750
67CLOCK_20551151_ChIP-Seq_293T_Human1.48381029
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48158457
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47079001
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47049809
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47049809
72VDR_24763502_ChIP-Seq_THP-1_Human1.46656641
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44324063
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.44298485
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43962396
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43138936
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42715812
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42243973
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40350564
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.40178038
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38609689
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38094216
83DROSHA_22980978_ChIP-Seq_HELA_Human1.32294404
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32180164
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30883709
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.28930510
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28127836
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.25419637
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.24833344
90TP53_16413492_ChIP-PET_HCT116_Human1.22889002
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20676822
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19492920
93ZNF274_21170338_ChIP-Seq_K562_Hela1.18623178
94GATA4_21415370_ChIP-Seq_HL-1_Mouse1.17855985
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17576653
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17446679
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16562716
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16288678
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.14874037
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.14120913
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.14120913
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.13269074
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11059785
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11008093
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.10971436
106VDR_21846776_ChIP-Seq_THP-1_Human1.09573386
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09032020
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08678966
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08477528
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08232115
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08192429
112SA1_22415368_ChIP-Seq_MEFs_Mouse1.08078973
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07911329
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.07539406
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06292979
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.05724363
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.05690212
118MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03397552
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.02774772
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.02732158
121TP53_23651856_ChIP-Seq_MEFs_Mouse1.02373898
122RXR_22108803_ChIP-Seq_LS180_Human1.02053748
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01789340
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01582409
125ATF3_27146783_Chip-Seq_COLON_Human1.00970724
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.00932289
127TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00886703
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00588783
129TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00065865
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99898373
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99745818
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98937750
133AR_19668381_ChIP-Seq_PC3_Human0.95049048
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95013941
135KDM2B_26808549_Chip-Seq_K562_Human0.94281023
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93732964
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93585268
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.93213898
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93113492
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92486869
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92188540
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92153285
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91073070
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89730487
145NFI_21473784_ChIP-Seq_ESCs_Mouse0.85889644
146PU_27001747_Chip-Seq_BMDM_Mouse0.83673641
147EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82144454
148TFEB_21752829_ChIP-Seq_HELA_Human0.82084530
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81178890
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79899653
151STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79244184
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78739161
153TP63_23658742_ChIP-Seq_EP156T_Human0.77464168
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75863564
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.75815615
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.75479447
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74967645
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74089468
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72660133
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.71573336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.48323918
2MP0005503_abnormal_tendon_morphology5.83840044
3MP0005275_abnormal_skin_tensile4.31844441
4MP0003950_abnormal_plasma_membrane3.94898666
5MP0003122_maternal_imprinting3.92569040
6MP0004134_abnormal_chest_morphology3.00368870
7MP0003705_abnormal_hypodermis_morpholog2.87281583
8MP0004272_abnormal_basement_membrane2.85474246
9MP0009250_abnormal_appendicular_skeleto2.83528597
10MP0003279_aneurysm2.80001089
11MP0010030_abnormal_orbit_morphology2.70080543
12MP0006054_spinal_hemorrhage2.51961736
13MP0002282_abnormal_trachea_morphology2.44212372
14MP0003123_paternal_imprinting2.43755012
15MP0005508_abnormal_skeleton_morphology2.42682797
16MP0003385_abnormal_body_wall2.24765688
17MP0009384_cardiac_valve_regurgitation2.23572292
18MP0002108_abnormal_muscle_morphology2.06587941
19MP0000163_abnormal_cartilage_morphology2.03471538
20MP0001958_emphysema1.97121964
21MP0002896_abnormal_bone_mineralization1.90948919
22MP0002115_abnormal_skeleton_extremities1.90289482
23MP0003121_genomic_imprinting1.88601822
24MP0002249_abnormal_larynx_morphology1.82693583
25MP0002877_abnormal_melanocyte_morpholog1.81922276
26MP0001299_abnormal_eye_distance/1.81915879
27MP0003755_abnormal_palate_morphology1.77355656
28MP0000762_abnormal_tongue_morphology1.77248078
29MP0010386_abnormal_urinary_bladder1.76466721
30MP0009053_abnormal_anal_canal1.73235079
31MP0001348_abnormal_lacrimal_gland1.70666740
32MP0001270_distended_abdomen1.70657757
33MP0000749_muscle_degeneration1.69242067
34MP0000049_abnormal_middle_ear1.68404127
35MP0002932_abnormal_joint_morphology1.66933799
36MP0005257_abnormal_intraocular_pressure1.64342103
37MP0002113_abnormal_skeleton_development1.61259897
38MP0003942_abnormal_urinary_system1.60098609
39MP0003937_abnormal_limbs/digits/tail_de1.58648329
40MP0000566_synostosis1.58508847
41MP0000428_abnormal_craniofacial_morphol1.58131283
42MP0005623_abnormal_meninges_morphology1.57376244
43MP0002933_joint_inflammation1.56798066
44MP0002109_abnormal_limb_morphology1.55633431
45MP0000733_abnormal_muscle_development1.52012587
46MP0000534_abnormal_ureter_morphology1.44412574
47MP0003935_abnormal_craniofacial_develop1.42316495
48MP0009780_abnormal_chondrocyte_physiolo1.42020814
49MP0002116_abnormal_craniofacial_bone1.41823533
50MP0004145_abnormal_muscle_electrophysio1.40161707
51MP0002089_abnormal_postnatal_growth/wei1.39311223
52MP0005390_skeleton_phenotype1.39251018
53MP0005595_abnormal_vascular_smooth1.38528140
54MP0001661_extended_life_span1.37641484
55MP0002233_abnormal_nose_morphology1.35606215
56MP0005076_abnormal_cell_differentiation1.33257949
57MP0002060_abnormal_skin_morphology1.32895519
58MP0000432_abnormal_head_morphology1.30929082
59MP0003115_abnormal_respiratory_system1.24724973
60MP0003566_abnormal_cell_adhesion1.24170691
61MP0003448_altered_tumor_morphology1.23728868
62MP0003283_abnormal_digestive_organ1.23066578
63MP0003191_abnormal_cellular_cholesterol1.19674968
64MP0003045_fibrosis1.16865462
65MP0006082_CNS_inflammation1.15367847
66MP0000537_abnormal_urethra_morphology1.15075549
67MP0002938_white_spotting1.14709603
68MP0001243_abnormal_dermal_layer1.14284794
69MP0002295_abnormal_pulmonary_circulatio1.13383766
70MP0000751_myopathy1.13375542
71MP0002114_abnormal_axial_skeleton1.12424898
72MP0001542_abnormal_bone_strength1.10093749
73MP0005058_abnormal_lysosome_morphology1.09953631
74MP0000685_abnormal_immune_system1.09331461
75MP0000343_altered_response_to1.08883334
76MP0000462_abnormal_digestive_system1.06764462
77MP0004197_abnormal_fetal_growth/weight/1.04665232
78MP0000767_abnormal_smooth_muscle1.03661569
79MP0003941_abnormal_skin_development1.02906922
80MP0002111_abnormal_tail_morphology1.02207071
81MP0003091_abnormal_cell_migration1.00192609
82MP0001879_abnormal_lymphatic_vessel0.98942359
83MP0005023_abnormal_wound_healing0.98817885
84MP0005164_abnormal_response_to0.98592909
85MP0004036_abnormal_muscle_relaxation0.95527525
86MP0003828_pulmonary_edema0.94138633
87MP0000858_altered_metastatic_potential0.94076553
88MP0005197_abnormal_uvea_morphology0.93739090
89MP0004510_myositis0.93605121
90MP0003300_gastrointestinal_ulcer0.93488901
91MP0001853_heart_inflammation0.93106936
92MP0003567_abnormal_fetal_cardiomyocyte0.92128766
93MP0002837_dystrophic_cardiac_calcinosis0.91710701
94MP0000747_muscle_weakness0.90880889
95MP0003795_abnormal_bone_structure0.89861621
96MP0000003_abnormal_adipose_tissue0.89332545
97MP0002269_muscular_atrophy0.87777306
98MP0005171_absent_coat_pigmentation0.86647182
99MP0009703_decreased_birth_body0.84302512
100MP0004264_abnormal_extraembryonic_tissu0.84029520
101MP0005620_abnormal_muscle_contractility0.83778575
102MP0010368_abnormal_lymphatic_system0.83573256
103MP0000013_abnormal_adipose_tissue0.83199760
104MP0004233_abnormal_muscle_weight0.83019629
105MP0005165_increased_susceptibility_to0.82637434
106MP0005369_muscle_phenotype0.82288358
107MP0002998_abnormal_bone_remodeling0.82160676
108MP0001175_abnormal_lung_morphology0.75054422
109MP0010352_gastrointestinal_tract_polyps0.74264431
110MP0001340_abnormal_eyelid_morphology0.72511865
111MP0000759_abnormal_skeletal_muscle0.72193783
112MP0005193_abnormal_anterior_eye0.71492568
113MP0005621_abnormal_cell_physiology0.70752349
114MP0002128_abnormal_blood_circulation0.70438439
115MP0004087_abnormal_muscle_fiber0.68215217
116MP0005464_abnormal_platelet_physiology0.68005461
117MP0006138_congestive_heart_failure0.67340743
118MP0001533_abnormal_skeleton_physiology0.67273308
119MP0000750_abnormal_muscle_regeneration0.67256443
120MP0002234_abnormal_pharynx_morphology0.67042612
121MP0002925_abnormal_cardiovascular_devel0.66180410
122MP0005330_cardiomyopathy0.64835967
123MP0001177_atelectasis0.64285655
124MP0002177_abnormal_outer_ear0.63960932
125MP0005360_urolithiasis0.63225698
126MP0003075_altered_response_to0.63174288
127MP0001293_anophthalmia0.63160265
128MP0005248_abnormal_Harderian_gland0.62573108
129MP0005388_respiratory_system_phenotype0.62068976
130MP0002133_abnormal_respiratory_system0.62068976
131MP0001915_intracranial_hemorrhage0.61214749
132MP0002163_abnormal_gland_morphology0.60816701
133MP0004084_abnormal_cardiac_muscle0.60178407
134MP0009764_decreased_sensitivity_to0.59671838
135MP0000266_abnormal_heart_morphology0.59504177
136MP0000538_abnormal_urinary_bladder0.59368731
137MP0002168_other_aberrant_phenotype0.58213422
138MP0000249_abnormal_blood_vessel0.58189502
139MP0001614_abnormal_blood_vessel0.57516641
140MP0010630_abnormal_cardiac_muscle0.56005917
141MP0000516_abnormal_urinary_system0.55619281
142MP0009278_abnormal_bone_marrow0.53640354
143MP0009840_abnormal_foam_cell0.52374955

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.18390468
2Premature rupture of membranes (HP:0001788)5.58085259
3Epiphyseal dysplasia (HP:0002656)5.24495903
4Hypoplastic ischia (HP:0003175)4.84539391
5Spondylolisthesis (HP:0003302)4.58432890
6Neonatal short-limb short stature (HP:0008921)4.55291592
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.25356092
8Abnormality of the ischium (HP:0003174)4.22741391
9Vascular tortuosity (HP:0004948)4.19532878
10Shallow orbits (HP:0000586)4.19255006
11Arterial tortuosity (HP:0005116)4.01497451
12Broad metatarsal (HP:0001783)3.81199559
13Mesomelia (HP:0003027)3.71380829
14Ankle contracture (HP:0006466)3.67466234
15Mild short stature (HP:0003502)3.62303337
16Short 4th metacarpal (HP:0010044)3.61919015
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.61919015
18Irregular epiphyses (HP:0010582)3.51585376
19Small epiphyses (HP:0010585)3.43476417
20Aortic dissection (HP:0002647)3.43138499
21Bell-shaped thorax (HP:0001591)3.38037197
22Osteoarthritis (HP:0002758)3.35080884
23Flat capital femoral epiphysis (HP:0003370)3.34836328
24Type 1 muscle fiber predominance (HP:0003803)3.27551823
25Atrophic scars (HP:0001075)3.21923092
26Abnormality of dentin (HP:0010299)3.21182493
27Cervical subluxation (HP:0003308)3.19534119
28Soft skin (HP:0000977)3.18666823
29Vertebral compression fractures (HP:0002953)3.16224603
30Aortic regurgitation (HP:0001659)3.15574583
31Bladder diverticulum (HP:0000015)3.12310016
32Follicular hyperkeratosis (HP:0007502)3.12106582
33Genu recurvatum (HP:0002816)3.11541084
34Peritonitis (HP:0002586)3.06637950
35Amyloidosis (HP:0011034)3.01312700
36Mitral valve prolapse (HP:0001634)3.00487637
37Hip contracture (HP:0003273)2.90686634
38Cupped ribs (HP:0000887)2.87491942
39Abnormality of the 4th metacarpal (HP:0010012)2.84898136
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.80038854
41Osteolytic defects of the hand bones (HP:0009699)2.80038854
42Vitreoretinal degeneration (HP:0000655)2.79402262
43Limited hip movement (HP:0008800)2.77643022
44Increased variability in muscle fiber diameter (HP:0003557)2.75901883
45Delayed epiphyseal ossification (HP:0002663)2.72157725
46Broad long bones (HP:0005622)2.70570806
47Wide anterior fontanel (HP:0000260)2.70044258
48Blue sclerae (HP:0000592)2.69777110
49Dilatation of the ascending aorta (HP:0005111)2.69604683
50Asymmetry of the thorax (HP:0001555)2.69480767
51Abnormality of the pubic bones (HP:0003172)2.66914671
52Round ear (HP:0100830)2.65346867
53Exostoses (HP:0100777)2.63935917
54Fragile skin (HP:0001030)2.58052474
55Wormian bones (HP:0002645)2.57604562
56Slender build (HP:0001533)2.56606394
57Mitral stenosis (HP:0001718)2.54424210
58Abnormality of skeletal muscle fiber size (HP:0012084)2.50762204
59Biconcave vertebral bodies (HP:0004586)2.49987006
60Platyspondyly (HP:0000926)2.47864201
61Mitral regurgitation (HP:0001653)2.47116268
62Microglossia (HP:0000171)2.45804986
63Spinal rigidity (HP:0003306)2.44733499
64Joint laxity (HP:0001388)2.42485748
65Breech presentation (HP:0001623)2.41161412
66Broad phalanx (HP:0006009)2.40348793
67Dislocated radial head (HP:0003083)2.38989518
68Hepatoblastoma (HP:0002884)2.37972526
69Flat acetabular roof (HP:0003180)2.37882304
70Ectopia lentis (HP:0001083)2.37803852
71Mildly elevated creatine phosphokinase (HP:0008180)2.33008073
72Aneurysm (HP:0002617)2.32747865
73Infantile muscular hypotonia (HP:0008947)2.32623614
74Broad thumb (HP:0011304)2.31345998
75Abnormality of the acetabulum (HP:0003170)2.31278105
76Rhizomelia (HP:0008905)2.30583116
77Abnormality of the radial head (HP:0003995)2.26529501
78Wrist flexion contracture (HP:0001239)2.25313087
79Abnormality of carpal bone ossification (HP:0006257)2.23937971
80Cerebral aneurysm (HP:0004944)2.19460767
81Genu varum (HP:0002970)2.19312450
82Long toe (HP:0010511)2.18518898
83Disproportionate tall stature (HP:0001519)2.17695510
84Aortic aneurysm (HP:0004942)2.17333734
85Generalized amyotrophy (HP:0003700)2.16928463
86Hyperextensible skin (HP:0000974)2.16257644
87Abnormal ossification of hand bones (HP:0005921)2.13983047
88Nemaline bodies (HP:0003798)2.11486853
89Broad phalanges of the hand (HP:0009768)2.10537067
90Delayed closure of the anterior fontanelle (HP:0001476)2.09891147
91Broad finger (HP:0001500)2.09594084
92Cardiovascular calcification (HP:0011915)2.08879773
93Deviation of the hallux (HP:0010051)2.08861711
94Thoracolumbar scoliosis (HP:0002944)2.08660459
95Morphological abnormality of the middle ear (HP:0008609)2.08606403
96Reduced subcutaneous adipose tissue (HP:0003758)2.08313222
97Elbow flexion contracture (HP:0002987)2.05355020
98Abnormal delivery (HP:0001787)2.05344089
99Ulnar bowing (HP:0003031)2.04852524
100Abnormal hand bone ossification (HP:0010660)2.04699690
101Bowel diverticulosis (HP:0005222)2.04458751
102Coxa vara (HP:0002812)2.04043865
103Lumbar hyperlordosis (HP:0002938)2.02431356
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.01650204
105Overgrowth (HP:0001548)2.01509841
106Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.00321859
107Abnormality of femoral epiphyses (HP:0006499)2.00321859
108Knee flexion contracture (HP:0006380)2.00179782
109Craniofacial hyperostosis (HP:0004493)2.00174217
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99553496
111Increased mean platelet volume (HP:0011877)1.99443201
112Hypoventilation (HP:0002791)1.99296169
113Broad face (HP:0000283)1.99197456
114Absent frontal sinuses (HP:0002688)1.98981421
115Limited elbow extension (HP:0001377)1.97723725
116Relative macrocephaly (HP:0004482)1.97402668
117Hallux valgus (HP:0001822)1.96979957
118Joint stiffness (HP:0001387)1.96253912
119Vertebral arch anomaly (HP:0008438)1.95039789
120Camptodactyly of toe (HP:0001836)1.94235158
121Femoral bowing (HP:0002980)1.94026478
122Conjunctival telangiectasia (HP:0000524)1.93711150
123Abnormality of the humeroradial joint (HP:0100744)1.93152315
124Increased connective tissue (HP:0009025)1.92826114
125Broad ribs (HP:0000885)1.92405290
126Long clavicles (HP:0000890)1.91262836
127Micromelia (HP:0002983)1.90553380
128Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90187792
129Coronal craniosynostosis (HP:0004440)1.88188822
130Tibial bowing (HP:0002982)1.88046843
131Delayed gross motor development (HP:0002194)1.87786809
132Abnormal tarsal ossification (HP:0008369)1.87450612
133Nonimmune hydrops fetalis (HP:0001790)1.87342791
134Delayed cranial suture closure (HP:0000270)1.86783588
135Short nail (HP:0001799)1.85826425
136Neoplasm of the heart (HP:0100544)1.84255481
137Aortic valve stenosis (HP:0001650)1.84025017
138Ovoid vertebral bodies (HP:0003300)1.82154185
139Cranial hyperostosis (HP:0004437)1.79344012
140Ulnar deviation of the wrist (HP:0003049)1.78526762
141Abnormality of liposaccharide metabolism (HP:0010968)1.77346413
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.77346413
143Abnormality of glycolipid metabolism (HP:0010969)1.77346413
144Abnormal platelet volume (HP:0011876)1.76992648
145Deformed tarsal bones (HP:0008119)1.76195267
146Abnormality of skull ossification (HP:0002703)1.75479599
147Muscle fiber inclusion bodies (HP:0100299)1.74906139
148Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73463846
149Calcaneovalgus deformity (HP:0001848)1.72074872
150Increased density of long bones (HP:0006392)1.70902055
151Asymmetric septal hypertrophy (HP:0001670)1.70559336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.90903898
2MYLK5.43104171
3SIK15.15172084
4LATS14.18945740
5EPHA33.79062069
6LIMK12.99997594
7TRIB32.91167051
8PKN22.83164299
9PDGFRA2.79550463
10MST1R2.49251157
11LATS22.48470398
12TTN2.28726457
13EPHB22.22030267
14MOS2.16189429
15TESK12.05253596
16IRAK31.95197357
17FGFR11.73137795
18STK31.62522866
19FGFR21.47401013
20CDK81.36908372
21RIPK11.34263694
22KIT1.29473609
23CCNB11.28256044
24MAP3K31.22979363
25DMPK1.21316658
26MAP2K31.19898997
27PTK61.19609489
28ERN11.15234843
29FER1.14774126
30BMX1.14095209
31ABL21.13970266
32TESK21.13925426
33MTOR1.10358821
34MET1.09341294
35PTK21.08924165
36PAK21.06518742
37STK38L1.06290757
38MAP3K101.05173115
39MELK1.04936732
40ROCK11.04811913
41FLT31.02130058
42CAMK1D0.99297797
43TGFBR20.97570937
44SCYL20.97301216
45PDGFRB0.96417252
46PLK20.96354924
47DAPK30.96274621
48MAPKAPK30.95455697
49PAK10.92998774
50PIM20.92547211
51FGFR40.92063141
52MAP3K140.89887726
53ARAF0.89584689
54EIF2AK20.88833504
55RPS6KA20.88447136
56CLK10.86620631
57CAMK1G0.86051777
58PRPF4B0.85309773
59MAP3K130.85016445
60ERBB30.84507446
61CSF1R0.83711913
62CDK120.83564359
63PRKD30.82420164
64NUAK10.81641427
65ERBB40.81367551
66WNK10.81233484
67JAK30.79344903
68PAK30.78381430
69MAP3K80.77268617
70JAK10.76810966
71STK100.75561094
72MAP3K60.75078122
73PRKCH0.72270395
74MAPK120.72143163
75PAK40.71373689
76PDK20.70245004
77MAPK110.69668414
78ROCK20.69352558
79NEK10.69179431
80MAPKAPK20.69120405
81MAP3K120.68534052
82PIK3CA0.68082445
83BCKDK0.67204152
84PAK60.66285811
85ILK0.65119733
86CDC70.64296285
87OBSCN0.64247713
88CSNK1A1L0.64120230
89GSK3A0.62994992
90PTK2B0.61703904
91ICK0.61665113
92LMTK20.61192215
93TRPM70.57940383
94BCR0.56395869
95GRK70.55889786
96CAMK2G0.55182225
97NTRK10.53500116
98ERBB20.53360994
99MAPK70.51708173
100ADRBK10.51702446
101LRRK20.51386911
102NEK90.51240168
103NME20.50948508
104EPHA40.48458982
105CDK150.48301916
106PRKCE0.48065208
107KDR0.47485474
108NTRK30.46202097
109STK240.45263270
110KSR10.44964622
111CHUK0.43344926
112CDK11A0.43142119
113CDK180.42913495
114SMG10.42497482
115RET0.42270266
116CDC42BPA0.42167245
117FGFR30.41988819
118EEF2K0.41932951
119CDK70.41404066
120INSR0.41403249
121MAPK40.41388354
122INSRR0.41043206
123MAP3K50.40201200
124CAMK2D0.39974970
125CDK140.39732562
126KSR20.38768736
127CDK60.36877454
128MAPK10.36109066
129PDPK10.35983832
130SRC0.35631823
131EPHB10.35200712
132RPS6KL10.35168389
133RPS6KC10.35168389
134TGFBR10.34582373
135CAMKK10.34116163
136PRKD10.34116054
137TBK10.33880022
138MUSK0.33315686
139PRKD20.32666257
140RPS6KA40.32331401
141CAMK40.31750958
142ZAK0.30805757
143PLK30.28286894
144TAOK20.27237472
145IGF1R0.26941007
146MAPK80.25468272
147AKT10.24788527
148FRK0.21929907
149STK380.19845462
150PRKG20.19599715
151MAPK140.19119853
152SGK30.18991877
153PRKCG0.18941046
154MKNK10.17695414
155MAP3K70.16859400
156MAP2K10.16665861
157PIK3CG0.16644103
158MAPK90.16439383
159MAPK100.15711644
160ABL10.15183174

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.18706479
2Protein digestion and absorption_Homo sapiens_hsa049744.84725223
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.49089656
4Focal adhesion_Homo sapiens_hsa045103.06182497
5Basal cell carcinoma_Homo sapiens_hsa052172.79924748
6Hedgehog signaling pathway_Homo sapiens_hsa043402.32937973
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.32828751
8Dilated cardiomyopathy_Homo sapiens_hsa054142.19882286
9Proteoglycans in cancer_Homo sapiens_hsa052052.19447527
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09983156
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.05787238
12Adherens junction_Homo sapiens_hsa045202.05650686
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04133115
14Hippo signaling pathway_Homo sapiens_hsa043901.89371466
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.78739443
16TGF-beta signaling pathway_Homo sapiens_hsa043501.71149206
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64234000
18Amoebiasis_Homo sapiens_hsa051461.63012282
19Other glycan degradation_Homo sapiens_hsa005111.62915782
20MicroRNAs in cancer_Homo sapiens_hsa052061.62031372
21Wnt signaling pathway_Homo sapiens_hsa043101.51112185
22Axon guidance_Homo sapiens_hsa043601.48769498
23Lysine degradation_Homo sapiens_hsa003101.46425355
24Shigellosis_Homo sapiens_hsa051311.42054051
25Pentose phosphate pathway_Homo sapiens_hsa000301.34007290
26Prostate cancer_Homo sapiens_hsa052151.32315444
27Malaria_Homo sapiens_hsa051441.30926031
28Melanogenesis_Homo sapiens_hsa049161.28086274
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27413644
30One carbon pool by folate_Homo sapiens_hsa006701.24188562
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23323135
32Salmonella infection_Homo sapiens_hsa051321.21051400
33Bladder cancer_Homo sapiens_hsa052191.17277236
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16134098
35Small cell lung cancer_Homo sapiens_hsa052221.15547276
36Pertussis_Homo sapiens_hsa051331.12725527
37Renin-angiotensin system_Homo sapiens_hsa046141.12606432
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10292683
39Viral myocarditis_Homo sapiens_hsa054161.05678970
40Chronic myeloid leukemia_Homo sapiens_hsa052201.04588964
41Pathways in cancer_Homo sapiens_hsa052001.04096033
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99984926
43Melanoma_Homo sapiens_hsa052180.99808353
44Glioma_Homo sapiens_hsa052140.99513994
45Notch signaling pathway_Homo sapiens_hsa043300.98904078
46Prion diseases_Homo sapiens_hsa050200.98670077
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98372614
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98185074
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97573829
50Insulin resistance_Homo sapiens_hsa049310.96891950
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96172060
52Lysosome_Homo sapiens_hsa041420.96028791
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95188917
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94704876
55Colorectal cancer_Homo sapiens_hsa052100.92069314
56Estrogen signaling pathway_Homo sapiens_hsa049150.91525561
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89649009
58Type II diabetes mellitus_Homo sapiens_hsa049300.87457639
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86119809
60Platelet activation_Homo sapiens_hsa046110.85613606
61HTLV-I infection_Homo sapiens_hsa051660.85023568
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84530338
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84170933
64Thyroid hormone synthesis_Homo sapiens_hsa049180.83331431
65Rap1 signaling pathway_Homo sapiens_hsa040150.83281619
66Phagosome_Homo sapiens_hsa041450.82298511
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.81029485
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.79847055
69mTOR signaling pathway_Homo sapiens_hsa041500.79648264
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79600946
71Apoptosis_Homo sapiens_hsa042100.79164504
72Pancreatic cancer_Homo sapiens_hsa052120.77995485
73Vibrio cholerae infection_Homo sapiens_hsa051100.77929220
74Tight junction_Homo sapiens_hsa045300.74132655
75Cocaine addiction_Homo sapiens_hsa050300.73460871
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72809718
77Endometrial cancer_Homo sapiens_hsa052130.71665939
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71164219
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69903054
80Ovarian steroidogenesis_Homo sapiens_hsa049130.69725595
81N-Glycan biosynthesis_Homo sapiens_hsa005100.67773035
82Influenza A_Homo sapiens_hsa051640.67693884
83Renal cell carcinoma_Homo sapiens_hsa052110.67360585
84Gap junction_Homo sapiens_hsa045400.67292416
85AMPK signaling pathway_Homo sapiens_hsa041520.66718624
86GnRH signaling pathway_Homo sapiens_hsa049120.63772487
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62421684
88Endocytosis_Homo sapiens_hsa041440.61810621
89cAMP signaling pathway_Homo sapiens_hsa040240.61644584
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61421493
91Hepatitis B_Homo sapiens_hsa051610.60127192
92DNA replication_Homo sapiens_hsa030300.58144199
93Glucagon signaling pathway_Homo sapiens_hsa049220.57759314
94Osteoclast differentiation_Homo sapiens_hsa043800.56843479
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.56108041
96Galactose metabolism_Homo sapiens_hsa000520.55644212
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55357927
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54903206
99Amphetamine addiction_Homo sapiens_hsa050310.53863458
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.53730664
101TNF signaling pathway_Homo sapiens_hsa046680.53497909
102Insulin signaling pathway_Homo sapiens_hsa049100.52399531
103Leishmaniasis_Homo sapiens_hsa051400.51474591
104Glycerolipid metabolism_Homo sapiens_hsa005610.51102832
105MAPK signaling pathway_Homo sapiens_hsa040100.51090798
106Thyroid cancer_Homo sapiens_hsa052160.50858913
107FoxO signaling pathway_Homo sapiens_hsa040680.50148301
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49734767
109Oxytocin signaling pathway_Homo sapiens_hsa049210.48620556
110Legionellosis_Homo sapiens_hsa051340.48375212
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48094609
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48066003
113p53 signaling pathway_Homo sapiens_hsa041150.48000191
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47926059
115Cholinergic synapse_Homo sapiens_hsa047250.46681021
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.45610769
117Biosynthesis of amino acids_Homo sapiens_hsa012300.45022708
118Cell cycle_Homo sapiens_hsa041100.43654364
119Circadian entrainment_Homo sapiens_hsa047130.43018692
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42745351
121beta-Alanine metabolism_Homo sapiens_hsa004100.42565067
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42545772
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.42405055
124Rheumatoid arthritis_Homo sapiens_hsa053230.42322926
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42018659
126Toxoplasmosis_Homo sapiens_hsa051450.40991996
127Sulfur metabolism_Homo sapiens_hsa009200.40951916
128ErbB signaling pathway_Homo sapiens_hsa040120.40455760
129Ras signaling pathway_Homo sapiens_hsa040140.40278575
130HIF-1 signaling pathway_Homo sapiens_hsa040660.39767854
131Insulin secretion_Homo sapiens_hsa049110.38927158
132African trypanosomiasis_Homo sapiens_hsa051430.38718707
133Tuberculosis_Homo sapiens_hsa051520.38161942
134Non-small cell lung cancer_Homo sapiens_hsa052230.37047536
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36895528
136Renin secretion_Homo sapiens_hsa049240.36828115
137Viral carcinogenesis_Homo sapiens_hsa052030.34801982
138Dorso-ventral axis formation_Homo sapiens_hsa043200.34094432
139Dopaminergic synapse_Homo sapiens_hsa047280.28716283
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28201219

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