ZCCHC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.53516779
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.93841132
3microglial cell activation (GO:0001774)4.66716870
4detection of external biotic stimulus (GO:0098581)4.36395923
5detection of other organism (GO:0098543)4.19214130
6cellular extravasation (GO:0045123)4.10352969
7macrophage activation (GO:0042116)4.02642591
8response to host immune response (GO:0052572)4.01841115
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.01841115
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98632765
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98632765
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91119112
13neutrophil mediated immunity (GO:0002446)3.89903614
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.86738647
15detection of biotic stimulus (GO:0009595)3.86434657
16neutrophil activation involved in immune response (GO:0002283)3.83905344
17negative regulation of B cell proliferation (GO:0030889)3.80807026
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.74295793
19response to host (GO:0075136)3.73669859
20response to host defenses (GO:0052200)3.73669859
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73669859
22B cell receptor signaling pathway (GO:0050853)3.69508515
23negative regulation of interleukin-12 production (GO:0032695)3.67754617
24positive regulation of gamma-delta T cell activation (GO:0046645)3.67416850
25antigen processing and presentation of endogenous antigen (GO:0019883)3.66881577
26protein targeting to Golgi (GO:0000042)3.62017778
27regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.61144892
28establishment of protein localization to Golgi (GO:0072600)3.57388784
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.57231357
30detection of bacterium (GO:0016045)3.57197112
31response to peptidoglycan (GO:0032494)3.56533023
32myeloid leukocyte mediated immunity (GO:0002444)3.53825757
33regulation of gamma-delta T cell differentiation (GO:0045586)3.48578811
34myeloid cell activation involved in immune response (GO:0002275)3.45847663
35negative regulation of T cell mediated immunity (GO:0002710)3.44174480
36retrograde transport, vesicle recycling within Golgi (GO:0000301)3.42527262
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.42217655
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41944694
39peptidyl-glutamic acid carboxylation (GO:0017187)3.40906829
40protein carboxylation (GO:0018214)3.40906829
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38305624
42regulation of B cell differentiation (GO:0045577)3.36515604
43response to interleukin-15 (GO:0070672)3.35718082
44complement activation, alternative pathway (GO:0006957)3.32124161
45negative T cell selection (GO:0043383)3.31161586
46negative thymic T cell selection (GO:0045060)3.26752145
47regulation of gamma-delta T cell activation (GO:0046643)3.25609485
48neutrophil activation (GO:0042119)3.25284302
49regulation of protein activation cascade (GO:2000257)3.20919834
50antigen processing and presentation via MHC class Ib (GO:0002475)3.20510622
51phospholipid homeostasis (GO:0055091)3.20304819
52cellular response to ethanol (GO:0071361)3.17336345
53regulation of alpha-beta T cell proliferation (GO:0046640)3.16970846
54alpha-linolenic acid metabolic process (GO:0036109)3.15235993
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14267536
56production of molecular mediator involved in inflammatory response (GO:0002532)3.14025116
57cellular response to interleukin-15 (GO:0071350)3.13126133
58positive T cell selection (GO:0043368)3.12696204
59plasma lipoprotein particle assembly (GO:0034377)3.12665392
60phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.10672604
61regulation of complement activation (GO:0030449)3.08958312
62leukocyte aggregation (GO:0070486)3.07557266
63phospholipid efflux (GO:0033700)3.07386240
64histone H3-K36 demethylation (GO:0070544)3.04314585
65urea cycle (GO:0000050)3.03193157
66urea metabolic process (GO:0019627)3.03193157
67protein-lipid complex assembly (GO:0065005)2.99464511
68negative regulation of adaptive immune response (GO:0002820)2.98362326
69respiratory burst (GO:0045730)2.97648955
70granulocyte activation (GO:0036230)2.97311091
71regulation of interferon-beta biosynthetic process (GO:0045357)2.97106480
72positive regulation of granulocyte differentiation (GO:0030854)2.95812794
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94821194
74negative regulation of leukocyte mediated immunity (GO:0002704)2.93987385
75regulation of triglyceride catabolic process (GO:0010896)2.92127639
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90504028
77L-phenylalanine catabolic process (GO:0006559)2.88506441
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88506441
79growth hormone receptor signaling pathway (GO:0060396)2.87910412
80dendritic cell migration (GO:0036336)2.86472137
81aromatic amino acid family catabolic process (GO:0009074)2.86339510
82immunoglobulin mediated immune response (GO:0016064)2.85350283
83negative regulation of sterol transport (GO:0032372)2.85105680
84negative regulation of cholesterol transport (GO:0032375)2.85105680
85I-kappaB phosphorylation (GO:0007252)2.80793669
86T cell migration (GO:0072678)2.80786809
87bile acid and bile salt transport (GO:0015721)2.80192088
88cellular response to type I interferon (GO:0071357)2.79889979
89type I interferon signaling pathway (GO:0060337)2.79889979
90regulation of cholesterol homeostasis (GO:2000188)2.79740208
91response to type I interferon (GO:0034340)2.78898996
92tryptophan catabolic process (GO:0006569)2.77974118
93indole-containing compound catabolic process (GO:0042436)2.77974118
94indolalkylamine catabolic process (GO:0046218)2.77974118
95negative regulation of fibrinolysis (GO:0051918)2.77055548
96positive regulation of interferon-beta production (GO:0032728)2.75900716
97myeloid leukocyte activation (GO:0002274)2.75322433
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.74686986
99interferon-gamma-mediated signaling pathway (GO:0060333)2.74453231
100high-density lipoprotein particle remodeling (GO:0034375)2.73485955
101positive regulation of mast cell activation (GO:0033005)2.73478943
102negative regulation of immunoglobulin mediated immune response (GO:0002890)2.72899430
103negative regulation of B cell mediated immunity (GO:0002713)2.72899430
104positive regulation by symbiont of host defense response (GO:0052509)2.72419792
105modulation by symbiont of host defense response (GO:0052031)2.72419792
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72419792
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72419792
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.72419792
109modulation by symbiont of host immune response (GO:0052553)2.72419792
110interferon-gamma production (GO:0032609)2.71807366
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71607319
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71445254
113cholesterol efflux (GO:0033344)2.71195690
114tryptophan metabolic process (GO:0006568)2.70787210
115reverse cholesterol transport (GO:0043691)2.70236174
116T-helper 1 type immune response (GO:0042088)2.69304567
117kynurenine metabolic process (GO:0070189)2.68789147
118positive regulation of histone deacetylation (GO:0031065)2.68082020
119defense response to protozoan (GO:0042832)2.65961824
120plasma lipoprotein particle clearance (GO:0034381)2.65781368
121positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65319413
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63161698
123regulation of interleukin-6 biosynthetic process (GO:0045408)2.63046867
124nitrogen cycle metabolic process (GO:0071941)2.63040782
125negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63011542
126negative regulation of T-helper cell differentiation (GO:0045623)2.63011542
127positive regulation of lipid catabolic process (GO:0050996)2.62319962
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.61307311
129response to laminar fluid shear stress (GO:0034616)2.60230117
130L-phenylalanine metabolic process (GO:0006558)2.58626577
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58626577
132bile acid biosynthetic process (GO:0006699)2.58391020
133protein-lipid complex remodeling (GO:0034368)2.57914528
134macromolecular complex remodeling (GO:0034367)2.57914528
135plasma lipoprotein particle remodeling (GO:0034369)2.57914528
136cysteine metabolic process (GO:0006534)2.56882642
137positive regulation of B cell differentiation (GO:0045579)2.56031785
138regulation of fibrinolysis (GO:0051917)2.55968832
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54300401
140definitive hemopoiesis (GO:0060216)2.54031587
141bile acid metabolic process (GO:0008206)2.52944495
142very-low-density lipoprotein particle assembly (GO:0034379)2.52793935
143negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.52657174
144positive thymic T cell selection (GO:0045059)2.52051742
145plasma lipoprotein particle organization (GO:0071827)2.51845027
146regulation of cholesterol storage (GO:0010885)2.50766509
147positive regulation of interferon-alpha production (GO:0032727)2.49154188
148hepatocyte apoptotic process (GO:0097284)2.48481146
149protein-lipid complex subunit organization (GO:0071825)2.48103894
150homocysteine metabolic process (GO:0050667)2.44495802
151lysine catabolic process (GO:0006554)2.44279058
152lysine metabolic process (GO:0006553)2.44279058
153regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41472163
154regulation of B cell receptor signaling pathway (GO:0050855)2.41099756
155low-density lipoprotein particle clearance (GO:0034383)2.41018702
156positive regulation of p38MAPK cascade (GO:1900745)2.40263670
157regulation of interferon-alpha production (GO:0032647)2.40109553
158positive regulation of glycolytic process (GO:0045821)2.39767274
159cellular response to growth hormone stimulus (GO:0071378)2.39608433
160fibrinolysis (GO:0042730)2.38416780
161triglyceride homeostasis (GO:0070328)2.37936414
162acylglycerol homeostasis (GO:0055090)2.37936414
163negative regulation of protein activation cascade (GO:2000258)2.37363081
164lipoprotein metabolic process (GO:0042157)2.36186568
165positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35913103
166macrophage activation involved in immune response (GO:0002281)2.35812885
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.35452040
168sulfur amino acid catabolic process (GO:0000098)2.34903536
169negative regulation of cell killing (GO:0031342)2.34140202
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34140202
171negative regulation of lipid storage (GO:0010888)2.33706185
172intestinal cholesterol absorption (GO:0030299)2.33163412
173cholesterol homeostasis (GO:0042632)2.32696733
174regulation of fatty acid beta-oxidation (GO:0031998)2.31744977
175sterol homeostasis (GO:0055092)2.30813762
176embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29044884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.64619532
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08067581
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.87289752
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.42407840
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39807704
6GATA1_22025678_ChIP-Seq_K562_Human3.32495829
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.15000763
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.10772409
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99955836
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.96973071
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80122750
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.75218791
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.54491774
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40257133
15SCL_19346495_ChIP-Seq_HPC-7_Human2.36127902
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.36106172
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.25202373
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23273144
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22842750
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17338785
21RUNX_20019798_ChIP-Seq_JUKART_Human2.12407594
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08854368
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04416043
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02657840
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95062353
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87101860
27* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85525874
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84433040
29* SPI1_23547873_ChIP-Seq_NB4_Human1.81410879
30CLOCK_20551151_ChIP-Seq_293T_Human1.76050383
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.69594670
32GATA1_19941826_ChIP-Seq_K562_Human1.66994142
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.66687739
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.65901104
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.64668190
36GATA3_26560356_Chip-Seq_TH2_Human1.64325248
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62114290
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60806158
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.56626403
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52697652
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52307266
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51949121
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49787476
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.47820320
45MAF_26560356_Chip-Seq_TH1_Human1.46603780
46GATA2_19941826_ChIP-Seq_K562_Human1.46368277
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45699797
48MYB_26560356_Chip-Seq_TH2_Human1.45079949
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42205386
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41550899
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.41305765
52MYB_26560356_Chip-Seq_TH1_Human1.40145836
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38760945
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33102311
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30654218
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30021496
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29789159
58SPI1_23127762_ChIP-Seq_K562_Human1.28898410
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28370057
60MYC_22102868_ChIP-Seq_BL_Human1.27619782
61VDR_24787735_ChIP-Seq_THP-1_Human1.27396140
62VDR_24763502_ChIP-Seq_THP-1_Human1.22540154
63PU_27001747_Chip-Seq_BMDM_Mouse1.20940547
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18866411
65UTX_26944678_Chip-Seq_JUKART_Human1.18401858
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17049974
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16639438
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.16357103
69SMRT_27268052_Chip-Seq_Bcells_Human1.15570475
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15072211
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.14942703
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14652345
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14458911
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14419739
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14119378
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13796183
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13765066
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.13535780
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12743198
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11495648
81VDR_21846776_ChIP-Seq_THP-1_Human1.10567358
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.10512394
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10378746
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09830129
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.08502212
86KDM2B_26808549_Chip-Seq_DND41_Human1.08437163
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08077379
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07385166
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.06908164
90TP63_23658742_ChIP-Seq_EP156T_Human1.06668831
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.06665452
92GATA3_27048872_Chip-Seq_THYMUS_Human1.05785303
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05741655
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.05013445
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04564670
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04145463
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03982486
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03835200
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03504546
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02908754
101* ER_23166858_ChIP-Seq_MCF-7_Human1.02872675
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01164760
103SALL4_22934838_ChIP-ChIP_CD34+_Human1.01077114
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00813677
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.00122955
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.98786582
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98403520
108* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97267076
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96532057
110GATA4_25053715_ChIP-Seq_YYC3_Human0.95206668
111* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94652215
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94401155
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94294264
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94294264
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.93367560
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93081132
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92722732
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92722732
119TP53_16413492_ChIP-PET_HCT116_Human0.92166275
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.91408068
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91313817
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.89719381
123GATA6_25053715_ChIP-Seq_YYC3_Human0.89708760
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89708535
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89544377
126OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89362998
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.87037987
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87011754
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86164955
130* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85604643
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.85427378
132AHR_22903824_ChIP-Seq_MCF-7_Human0.85312787
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85258888
134GATA3_26560356_Chip-Seq_TH1_Human0.85156476
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85062496
136CDX2_22108803_ChIP-Seq_LS180_Human0.84999732
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83675211
138STAT3_23295773_ChIP-Seq_U87_Human0.82888060
139* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82266417
140CBP_20019798_ChIP-Seq_JUKART_Human0.81970739
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81970739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.97841776
2MP0005360_urolithiasis3.88321785
3MP0005085_abnormal_gallbladder_physiolo3.02045198
4MP0005365_abnormal_bile_salt3.01316417
5MP0003252_abnormal_bile_duct2.88464293
6MP0003300_gastrointestinal_ulcer2.65667068
7MP0008260_abnormal_autophagy2.39143405
8MP0003191_abnormal_cellular_cholesterol2.34236997
9MP0001835_abnormal_antigen_presentation2.16301896
10MP0005451_abnormal_body_composition2.09748006
11MP0008875_abnormal_xenobiotic_pharmacok2.04139763
12MP0002138_abnormal_hepatobiliary_system2.01765122
13MP0003656_abnormal_erythrocyte_physiolo2.01431541
14MP0003705_abnormal_hypodermis_morpholog1.97883683
15MP0004883_abnormal_blood_vessel1.97602225
16MP0003436_decreased_susceptibility_to1.97085868
17MP0003303_peritoneal_inflammation1.97005133
18MP0010329_abnormal_lipoprotein_level1.95131009
19MP0009840_abnormal_foam_cell1.91349668
20MP0002166_altered_tumor_susceptibility1.89303760
21MP0008057_abnormal_DNA_replication1.87684789
22MP0005310_abnormal_salivary_gland1.83648885
23MP0009278_abnormal_bone_marrow1.82320226
24MP0004381_abnormal_hair_follicle1.82145046
25MP0000015_abnormal_ear_pigmentation1.78638678
26MP0003724_increased_susceptibility_to1.75062810
27MP0000685_abnormal_immune_system1.74506089
28MP0001790_abnormal_immune_system1.73953121
29MP0005387_immune_system_phenotype1.73953121
30MP0005464_abnormal_platelet_physiology1.73514640
31MP0001800_abnormal_humoral_immune1.72882700
32MP0001666_abnormal_nutrient_absorption1.71333752
33MP0000569_abnormal_digit_pigmentation1.70903546
34MP0004947_skin_inflammation1.70615027
35MP0000609_abnormal_liver_physiology1.62096105
36MP0002419_abnormal_innate_immunity1.60902353
37MP0001545_abnormal_hematopoietic_system1.59469906
38MP0005397_hematopoietic_system_phenotyp1.59469906
39MP0002254_reproductive_system_inflammat1.58265015
40MP0005671_abnormal_response_to1.56947051
41MP0005164_abnormal_response_to1.53526318
42MP0002132_abnormal_respiratory_system1.50945976
43MP0002452_abnormal_antigen_presenting1.50601172
44MP0005025_abnormal_response_to1.50189891
45MP0003172_abnormal_lysosome_physiology1.49577284
46MP0009785_altered_susceptibility_to1.48280359
47MP0010155_abnormal_intestine_physiology1.46129166
48MP0003183_abnormal_peptide_metabolism1.46024822
49MP0002009_preneoplasia1.43893945
50MP0005000_abnormal_immune_tolerance1.41615854
51MP0005410_abnormal_fertilization1.41292491
52MP0002396_abnormal_hematopoietic_system1.39691566
53MP0003787_abnormal_imprinting1.39296824
54MP0010368_abnormal_lymphatic_system1.38914683
55MP0002723_abnormal_immune_serum1.38117342
56MP0010352_gastrointestinal_tract_polyps1.37251412
57MP0003868_abnormal_feces_composition1.34556153
58MP0001873_stomach_inflammation1.34093711
59MP0009764_decreased_sensitivity_to1.30053057
60MP0006082_CNS_inflammation1.28227080
61MP0001845_abnormal_inflammatory_respons1.28059634
62MP0001819_abnormal_immune_cell1.27143918
63MP0003566_abnormal_cell_adhesion1.27035145
64MP0002420_abnormal_adaptive_immunity1.27003006
65MP0004808_abnormal_hematopoietic_stem1.26412896
66MP0001533_abnormal_skeleton_physiology1.24704986
67MP0000703_abnormal_thymus_morphology1.24266782
68MP0002006_tumorigenesis1.21915091
69MP0005083_abnormal_biliary_tract1.21214256
70MP0005075_abnormal_melanosome_morpholog1.19733313
71MP0003866_abnormal_defecation1.18410149
72MP0008469_abnormal_protein_level1.17693777
73MP0001853_heart_inflammation1.17397903
74MP0002398_abnormal_bone_marrow1.17228371
75MP0006054_spinal_hemorrhage1.14937054
76MP0002118_abnormal_lipid_homeostasis1.14357349
77MP0002405_respiratory_system_inflammati1.14235114
78MP0010234_abnormal_vibrissa_follicle1.13462263
79MP0003763_abnormal_thymus_physiology1.11927157
80MP0004147_increased_porphyrin_level1.11786306
81MP0005023_abnormal_wound_healing1.09159055
82MP0000465_gastrointestinal_hemorrhage1.09092982
83MP0005174_abnormal_tail_pigmentation1.08392437
84MP0000716_abnormal_immune_system1.08176221
85MP0004130_abnormal_muscle_cell1.08026334
86MP0009763_increased_sensitivity_to1.06511964
87MP0005076_abnormal_cell_differentiation1.04379633
88MP0003453_abnormal_keratinocyte_physiol1.03554321
89MP0000371_diluted_coat_color1.03402247
90MP0000858_altered_metastatic_potential1.02688232
91MP0003806_abnormal_nucleotide_metabolis1.02607699
92MP0000598_abnormal_liver_morphology1.02298061
93MP0002877_abnormal_melanocyte_morpholog1.00505364
94MP0001879_abnormal_lymphatic_vessel0.99834457
95MP0004484_altered_response_of0.99164758
96MP0005319_abnormal_enzyme/_coenzyme0.98322177
97MP0002148_abnormal_hypersensitivity_rea0.98274970
98MP0000689_abnormal_spleen_morphology0.97941735
99MP0002928_abnormal_bile_duct0.97452745
100MP0003045_fibrosis0.97222891
101MP0010307_abnormal_tumor_latency0.96890699
102MP0008438_abnormal_cutaneous_collagen0.94672634
103MP0002332_abnormal_exercise_endurance0.94651549
104MP0008004_abnormal_stomach_pH0.94498679
105MP0005058_abnormal_lysosome_morphology0.94392443
106MP0008877_abnormal_DNA_methylation0.93964043
107MP0003091_abnormal_cell_migration0.93837699
108MP0004264_abnormal_extraembryonic_tissu0.93773266
109MP0002722_abnormal_immune_system0.93404113
110MP0003221_abnormal_cardiomyocyte_apopto0.93352485
111MP0009333_abnormal_splenocyte_physiolog0.93251507
112MP0002429_abnormal_blood_cell0.93189750
113MP0002060_abnormal_skin_morphology0.91587125
114MP0003943_abnormal_hepatobiliary_system0.86958174
115MP0002998_abnormal_bone_remodeling0.86725190
116MP0000249_abnormal_blood_vessel0.86435388
117MP0003195_calcinosis0.86148963
118MP0009643_abnormal_urine_homeostasis0.85569805
119MP0004510_myositis0.84711739
120MP0001243_abnormal_dermal_layer0.83355393
121MP0003448_altered_tumor_morphology0.82220498
122MP0005408_hypopigmentation0.80319352
123MP0003828_pulmonary_edema0.78948622
124MP0002933_joint_inflammation0.78690145
125MP0004019_abnormal_vitamin_homeostasis0.77832124
126MP0003075_altered_response_to0.77673681
127MP0000767_abnormal_smooth_muscle0.77600115
128MP0002136_abnormal_kidney_physiology0.76223405
129MP0001851_eye_inflammation0.76109874
130MP0005376_homeostasis/metabolism_phenot0.73870768
131MP0005166_decreased_susceptibility_to0.71854569
132MP0003690_abnormal_glial_cell0.70676121
133MP0009115_abnormal_fat_cell0.70337837
134MP0000604_amyloidosis0.69853021
135MP0009765_abnormal_xenobiotic_induced0.68445149
136MP0000427_abnormal_hair_cycle0.67915547
137MP0002277_abnormal_respiratory_mucosa0.60528029

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.72659163
2Retrobulbar optic neuritis (HP:0100654)4.72659163
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.60795600
4Deep venous thrombosis (HP:0002625)4.18047163
5Stomatitis (HP:0010280)3.97810434
6Intrahepatic cholestasis (HP:0001406)3.79439163
7Complement deficiency (HP:0004431)3.65310185
8Keratoconjunctivitis sicca (HP:0001097)3.58528176
9Myocardial infarction (HP:0001658)3.57867737
10Abnormality of macrophages (HP:0004311)3.52522106
11Xanthomatosis (HP:0000991)3.49606862
12Elevated erythrocyte sedimentation rate (HP:0003565)3.48355588
13Keratoconjunctivitis (HP:0001096)3.34375919
14Mediastinal lymphadenopathy (HP:0100721)3.33308049
15Meningitis (HP:0001287)3.21291401
16Acanthocytosis (HP:0001927)3.17895777
17Mitral stenosis (HP:0001718)3.16940884
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.15456880
19Gingival bleeding (HP:0000225)3.08769435
20Recurrent gram-negative bacterial infections (HP:0005420)3.08128379
21Joint hemorrhage (HP:0005261)3.03960892
22Prolonged partial thromboplastin time (HP:0003645)3.03515803
23Chest pain (HP:0100749)3.03046532
24Eczematoid dermatitis (HP:0000976)3.00868677
25Encephalitis (HP:0002383)2.99975170
26Abnormality of the common coagulation pathway (HP:0010990)2.98152020
27Spontaneous hematomas (HP:0007420)2.97475873
28Abnormality of the fingertips (HP:0001211)2.95470616
29Poikilocytosis (HP:0004447)2.93820658
30Autoimmune thrombocytopenia (HP:0001973)2.90873927
31Abnormality of T cells (HP:0002843)2.88459432
32Systemic lupus erythematosus (HP:0002725)2.86179479
33Recurrent bronchitis (HP:0002837)2.85219392
34Hyperlipoproteinemia (HP:0010980)2.83849633
35Hemoptysis (HP:0002105)2.78745186
36Colitis (HP:0002583)2.78590749
37Hypochromic microcytic anemia (HP:0004840)2.77901361
38Esophageal varix (HP:0002040)2.75460295
39Urticaria (HP:0001025)2.73972559
40Hematochezia (HP:0002573)2.73100852
41Recurrent viral infections (HP:0004429)2.73030585
42Obstructive lung disease (HP:0006536)2.71812539
43Chronic obstructive pulmonary disease (HP:0006510)2.71812539
44Resting tremor (HP:0002322)2.71289060
45Abnormality of complement system (HP:0005339)2.71131876
46Pulmonary infiltrates (HP:0002113)2.70440940
47Epidermoid cyst (HP:0200040)2.69008441
48Polycythemia (HP:0001901)2.66257329
49Recurrent fungal infections (HP:0002841)2.65428814
50Recurrent bacterial skin infections (HP:0005406)2.64867078
51Hypobetalipoproteinemia (HP:0003563)2.64221387
52Gangrene (HP:0100758)2.57365131
53Hypercholesterolemia (HP:0003124)2.53295921
54Abnormal platelet volume (HP:0011876)2.45832750
55Pustule (HP:0200039)2.45607770
56Osteomyelitis (HP:0002754)2.44787405
57Increased mean platelet volume (HP:0011877)2.44122731
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43251388
59Acute hepatic failure (HP:0006554)2.42560733
60Autoimmune hemolytic anemia (HP:0001890)2.42505378
61Epistaxis (HP:0000421)2.42142537
62Hypoalphalipoproteinemia (HP:0003233)2.40537304
63Aortic aneurysm (HP:0004942)2.39883860
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39868467
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37857275
66Periodontitis (HP:0000704)2.37585286
67Recurrent abscess formation (HP:0002722)2.36349720
68Hypolipoproteinemia (HP:0010981)2.35391149
69Hepatocellular carcinoma (HP:0001402)2.33682997
70Prolonged bleeding time (HP:0003010)2.30468601
71Anorexia (HP:0002039)2.30258700
72Impaired platelet aggregation (HP:0003540)2.29823135
73Abnormal platelet function (HP:0011869)2.29823135
74Papillary thyroid carcinoma (HP:0002895)2.29592351
75Inflammation of the large intestine (HP:0002037)2.29403798
76Neoplasm of the tracheobronchial system (HP:0100552)2.28280771
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.25527239
78Recurrent pneumonia (HP:0006532)2.24740418
79Menorrhagia (HP:0000132)2.23821852
80Abnormality of the peritoneum (HP:0002585)2.23315252
81Lymphopenia (HP:0001888)2.21565554
82Glomerulonephritis (HP:0000099)2.20081335
83Abnormality of eosinophils (HP:0001879)2.18096852
84Hemorrhage of the eye (HP:0011885)2.15271700
85Verrucae (HP:0200043)2.13650679
86Papilloma (HP:0012740)2.13650679
87Recurrent skin infections (HP:0001581)2.12553137
88Nephritis (HP:0000123)2.11730977
89Viral hepatitis (HP:0006562)2.11642238
90Gastrointestinal inflammation (HP:0004386)2.11344645
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.11036836
92Osteolytic defects of the hand bones (HP:0009699)2.10786361
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.10786361
94Chronic diarrhea (HP:0002028)2.10760538
95Cerebral aneurysm (HP:0004944)2.08599522
96Pulmonary embolism (HP:0002204)2.08375170
97Thyroiditis (HP:0100646)2.06494154
98Hypoglycemic coma (HP:0001325)2.06214998
99Fat malabsorption (HP:0002630)2.04255340
100Arterial thrombosis (HP:0004420)2.04171652
101Thrombophlebitis (HP:0004418)2.03979185
102Keratitis (HP:0000491)2.02618487
103Granulocytopenia (HP:0001913)2.02611685
104T lymphocytopenia (HP:0005403)2.02512235
105Abnormality of T cell physiology (HP:0011840)2.02355927
106Sepsis (HP:0100806)2.01451690
107Amaurosis fugax (HP:0100576)2.01449043
108Cellulitis (HP:0100658)1.99038601
109Amyloidosis (HP:0011034)1.98797598
110Chronic otitis media (HP:0000389)1.98614586
111Slow saccadic eye movements (HP:0000514)1.98491272
112Agammaglobulinemia (HP:0004432)1.98208540
113Episodic fever (HP:0001954)1.97994129
114Abnormality of T cell number (HP:0011839)1.97203343
115Subacute progressive viral hepatitis (HP:0006572)1.95916519
116Abnormality of the intrinsic pathway (HP:0010989)1.94998509
117Abnormality of the pleura (HP:0002103)1.92203321
118IgM deficiency (HP:0002850)1.90215679
119Glomerulopathy (HP:0100820)1.89158864
120Fatigue (HP:0012378)1.88100999
121Bronchitis (HP:0012387)1.86776976
122Volvulus (HP:0002580)1.86298786
123Vasculitis (HP:0002633)1.85444011
124Hypochromic anemia (HP:0001931)1.85138021
125Hyperbilirubinemia (HP:0002904)1.84649906
126Abnormality of iron homeostasis (HP:0011031)1.83402945
127Thick nail (HP:0001805)1.83211369
128Hepatitis (HP:0012115)1.82422298
129Mitral valve prolapse (HP:0001634)1.81231609
130Abnormality of the endocardium (HP:0004306)1.80549533
131Myositis (HP:0100614)1.80037457
132Postural instability (HP:0002172)1.79845395
133Menstrual irregularities (HP:0000858)1.79493377
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.79353217
135Peritonitis (HP:0002586)1.79239869
136Alveolar cell carcinoma (HP:0006519)1.78519681
137Gastrointestinal infarctions (HP:0005244)1.78347898
138Chronic mucocutaneous candidiasis (HP:0002728)1.77951489
139Recurrent cutaneous fungal infections (HP:0011370)1.77951489
140Abnormality of the nasal mucosa (HP:0000433)1.77865399
141Vertigo (HP:0002321)1.76587430
142Interstitial pulmonary disease (HP:0006530)1.76440966
143IgA deficiency (HP:0002720)1.76327845
144Eosinophilia (HP:0001880)1.76284719
145Skin ulcer (HP:0200042)1.75904739
146Panhypogammaglobulinemia (HP:0003139)1.75505666
147Disproportionate tall stature (HP:0001519)1.74947045
148Hyperammonemia (HP:0001987)1.74414088
149Reticulocytosis (HP:0001923)1.73894418
150Increased IgE level (HP:0003212)1.73768338
151Hypoplasia of the thymus (HP:0000778)1.73577143
152Conjunctival telangiectasia (HP:0000524)1.72610471
153Leukocytosis (HP:0001974)1.72362886
154Orchitis (HP:0100796)1.72017598
155Gingivitis (HP:0000230)1.70531313
156Spontaneous abortion (HP:0005268)1.70478175
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.68417590
158Acute myeloid leukemia (HP:0004808)1.67462780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN12.74178607
2MAP4K12.67158135
3TYK22.67014300
4FGFR42.58343468
5TAOK32.53246128
6TGFBR22.41747201
7JAK12.25199540
8CAMK1D2.21674213
9BMPR22.17751271
10MAP3K142.11050885
11STK101.96890582
12EPHB11.94854161
13MAP3K101.92192213
14PTK61.91313919
15SIK11.86646883
16TXK1.84696915
17TRIB31.84626617
18FGFR31.81687937
19IRAK11.81613185
20JAK31.81100870
21CDK121.76730048
22FGR1.76553132
23CAMK1G1.74939505
24RIPK11.69207427
25TBK11.66308442
26FES1.63100341
27MAP3K21.61840738
28FRK1.60691111
29IKBKE1.55634841
30KIT1.54008465
31ITK1.50017699
32PKN21.49484384
33EPHA31.48400105
34CDK61.46108792
35INSRR1.45943558
36AKT31.44173029
37CSK1.43187392
38IRAK21.42540390
39WNK11.41762881
40ZAP701.41155124
41MAP3K31.35835235
42YES11.31897357
43TIE11.31476884
44STK31.29355147
45CHUK1.24944360
46MAP3K71.24123399
47BRD41.24025676
48JAK21.23180075
49ACVR1B1.22626474
50TEC1.20180034
51NEK91.19712141
52PTK2B1.16066132
53MST1R1.12444005
54CAMKK21.12192249
55TNK21.09647566
56MAP2K31.07649999
57CSF1R1.06401995
58LRRK21.04859212
59GRK61.03570837
60IKBKB1.02552191
61TTN1.01483912
62MAP3K131.01181243
63BTK0.99090199
64MAP3K10.98152225
65HCK0.97843544
66IRAK40.94539762
67FLT30.92273485
68NUAK10.91978405
69SGK30.91276730
70PLK20.88118853
71PRKCH0.88113690
72PDGFRB0.88022585
73IRAK30.87282232
74KSR20.86201551
75PIM10.86153520
76LATS10.85466023
77SYK0.83875789
78PRKAA20.83722207
79FGFR20.82588653
80LCK0.82452595
81MAPK150.79637256
82STK380.78819142
83TRPM70.77787050
84PRKCQ0.77218509
85EEF2K0.77001890
86NLK0.76379966
87CDK90.75805186
88NEK60.75181497
89PRPF4B0.74995330
90MAPK110.73557438
91RAF10.71700901
92MARK20.71431295
93MAPK70.70735561
94TAOK10.70660818
95STK240.65688103
96KDR0.65307930
97MAP3K60.64661417
98MATK0.64315547
99EGFR0.63413805
100STK40.62550258
101PDGFRA0.62525338
102KSR10.60177828
103MARK30.59891373
104PIK3CA0.59434903
105MTOR0.59417259
106PAK30.58758629
107RET0.58610311
108RIPK40.58141691
109PLK40.56473928
110PDPK10.56069184
111BLK0.55959808
112PIK3CG0.55255817
113SGK4940.54388092
114SGK2230.54388092
115GSK3A0.54239822
116MAP3K50.54126072
117SIK20.53656865
118LYN0.53271606
119ERBB20.51664870
120HIPK20.50546620
121RPS6KA40.50092579
122IGF1R0.49961904
123BMX0.49462475
124MAPK120.48145226
125MELK0.47974813
126DYRK1B0.46787714
127CDK40.43131021
128SGK10.42988921
129CAMK40.41948738
130PDK10.40660609
131MAPK40.40409273
132TGFBR10.40270992
133SGK20.40122039
134FER0.38272169

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.82829944
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.81051976
3Staphylococcus aureus infection_Homo sapiens_hsa051502.75992464
4Caffeine metabolism_Homo sapiens_hsa002322.73655812
5Complement and coagulation cascades_Homo sapiens_hsa046102.57273918
6Graft-versus-host disease_Homo sapiens_hsa053322.24365065
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19081145
8Allograft rejection_Homo sapiens_hsa053302.06181527
9Autoimmune thyroid disease_Homo sapiens_hsa053201.94398636
10Arginine biosynthesis_Homo sapiens_hsa002201.86014321
11ABC transporters_Homo sapiens_hsa020101.79752289
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63813491
13PPAR signaling pathway_Homo sapiens_hsa033201.59820430
14Leishmaniasis_Homo sapiens_hsa051401.59031918
15Tryptophan metabolism_Homo sapiens_hsa003801.57749911
16Osteoclast differentiation_Homo sapiens_hsa043801.57103175
17Type I diabetes mellitus_Homo sapiens_hsa049401.48702356
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.47869177
19Fatty acid degradation_Homo sapiens_hsa000711.47107371
20Lysine degradation_Homo sapiens_hsa003101.44725260
21B cell receptor signaling pathway_Homo sapiens_hsa046621.41706553
22Fat digestion and absorption_Homo sapiens_hsa049751.28165028
23Bile secretion_Homo sapiens_hsa049761.28028501
24Toxoplasmosis_Homo sapiens_hsa051451.26615965
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23937424
26Primary immunodeficiency_Homo sapiens_hsa053401.22146562
27Measles_Homo sapiens_hsa051621.17585150
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14756911
29Fatty acid biosynthesis_Homo sapiens_hsa000611.13978352
30Hematopoietic cell lineage_Homo sapiens_hsa046401.11539123
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10311919
32Asthma_Homo sapiens_hsa053101.09385875
33Histidine metabolism_Homo sapiens_hsa003401.08796750
34Insulin resistance_Homo sapiens_hsa049311.08721641
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07668604
36Inositol phosphate metabolism_Homo sapiens_hsa005621.03408528
37Malaria_Homo sapiens_hsa051441.02804309
38TNF signaling pathway_Homo sapiens_hsa046681.02543821
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.01031962
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99972855
41Chronic myeloid leukemia_Homo sapiens_hsa052200.99929200
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.99306205
43Phagosome_Homo sapiens_hsa041450.99214024
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98418622
45Starch and sucrose metabolism_Homo sapiens_hsa005000.97709356
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.97571896
47Small cell lung cancer_Homo sapiens_hsa052220.97104140
48Chemical carcinogenesis_Homo sapiens_hsa052040.93199266
49Pertussis_Homo sapiens_hsa051330.92986694
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.92081378
51Hepatitis C_Homo sapiens_hsa051600.91819965
52Peroxisome_Homo sapiens_hsa041460.91267018
53Retinol metabolism_Homo sapiens_hsa008300.90890044
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90880946
55Influenza A_Homo sapiens_hsa051640.90722333
56T cell receptor signaling pathway_Homo sapiens_hsa046600.90603182
57Renal cell carcinoma_Homo sapiens_hsa052110.90472098
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89516991
59Selenocompound metabolism_Homo sapiens_hsa004500.86819436
60Acute myeloid leukemia_Homo sapiens_hsa052210.85230367
61Platelet activation_Homo sapiens_hsa046110.84974846
62Pancreatic cancer_Homo sapiens_hsa052120.83995220
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83965099
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.82455366
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81660116
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81079977
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80206551
68Fatty acid metabolism_Homo sapiens_hsa012120.79955130
69Amoebiasis_Homo sapiens_hsa051460.78706066
70Hepatitis B_Homo sapiens_hsa051610.78232152
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77496184
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77057619
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76776084
74VEGF signaling pathway_Homo sapiens_hsa043700.76421111
75Prostate cancer_Homo sapiens_hsa052150.75805097
76Vitamin digestion and absorption_Homo sapiens_hsa049770.72283895
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72281116
78Tuberculosis_Homo sapiens_hsa051520.71468253
79Rheumatoid arthritis_Homo sapiens_hsa053230.70844912
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.70759212
81Apoptosis_Homo sapiens_hsa042100.70620794
82mTOR signaling pathway_Homo sapiens_hsa041500.70441046
83Herpes simplex infection_Homo sapiens_hsa051680.70276172
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70095533
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69660741
86HIF-1 signaling pathway_Homo sapiens_hsa040660.68505153
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67780389
88Endometrial cancer_Homo sapiens_hsa052130.66750628
89beta-Alanine metabolism_Homo sapiens_hsa004100.66663252
90Dorso-ventral axis formation_Homo sapiens_hsa043200.66513226
91Antigen processing and presentation_Homo sapiens_hsa046120.65036532
92Shigellosis_Homo sapiens_hsa051310.64774439
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.63739968
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63004361
95Viral carcinogenesis_Homo sapiens_hsa052030.62785259
96Chemokine signaling pathway_Homo sapiens_hsa040620.62703395
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61952736
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61743673
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61120523
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60934784
101Viral myocarditis_Homo sapiens_hsa054160.60375356
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59989218
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59346435
104African trypanosomiasis_Homo sapiens_hsa051430.59293083
105Legionellosis_Homo sapiens_hsa051340.58425670
106Adherens junction_Homo sapiens_hsa045200.57107830
107Salmonella infection_Homo sapiens_hsa051320.56273819
108FoxO signaling pathway_Homo sapiens_hsa040680.55339239
109Prolactin signaling pathway_Homo sapiens_hsa049170.55192737
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.54751345
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54500823
112Choline metabolism in cancer_Homo sapiens_hsa052310.54329147
113Endocytosis_Homo sapiens_hsa041440.53476873
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52660329
115Type II diabetes mellitus_Homo sapiens_hsa049300.52517968
116Proteoglycans in cancer_Homo sapiens_hsa052050.51670351
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.51536350
118Phenylalanine metabolism_Homo sapiens_hsa003600.50779392
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49249445
120Focal adhesion_Homo sapiens_hsa045100.49015606
121Epstein-Barr virus infection_Homo sapiens_hsa051690.48935392
122ECM-receptor interaction_Homo sapiens_hsa045120.47762135
123Non-small cell lung cancer_Homo sapiens_hsa052230.47478319
124ErbB signaling pathway_Homo sapiens_hsa040120.47355438
125Propanoate metabolism_Homo sapiens_hsa006400.46921211
126Glycerolipid metabolism_Homo sapiens_hsa005610.46856926
127Sulfur metabolism_Homo sapiens_hsa009200.46216090
128MAPK signaling pathway_Homo sapiens_hsa040100.45442375
129Glioma_Homo sapiens_hsa052140.45246357
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43252491
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.43012119
132Colorectal cancer_Homo sapiens_hsa052100.42806761
133MicroRNAs in cancer_Homo sapiens_hsa052060.42461602
134Butanoate metabolism_Homo sapiens_hsa006500.42316281
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41400221
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41142605
137GnRH signaling pathway_Homo sapiens_hsa049120.40780542
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.40463553
139Regulation of autophagy_Homo sapiens_hsa041400.39442626
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39081588
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37574266
142HTLV-I infection_Homo sapiens_hsa051660.36792591
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34080315

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