ZCCHC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)5.16835789
2synapsis (GO:0007129)4.94149020
3axon ensheathment in central nervous system (GO:0032291)4.89034497
4central nervous system myelination (GO:0022010)4.89034497
5negative regulation of DNA-dependent DNA replication (GO:2000104)4.53922429
6presynaptic membrane assembly (GO:0097105)4.46772088
7regulation of meiosis I (GO:0060631)4.45287300
8intra-S DNA damage checkpoint (GO:0031573)4.27394232
9presynaptic membrane organization (GO:0097090)4.26029930
10histone H3-K4 trimethylation (GO:0080182)4.20395717
11neuron cell-cell adhesion (GO:0007158)4.12425238
12centriole replication (GO:0007099)4.09130375
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.03054491
14replication fork processing (GO:0031297)4.01572957
15glutamate receptor signaling pathway (GO:0007215)3.90442779
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79878876
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.70998767
18regulation of histone H3-K9 methylation (GO:0051570)3.61044564
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.57451164
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.57451164
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.57451164
22DNA ligation (GO:0006266)3.53033110
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.52692665
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51780653
25meiotic chromosome segregation (GO:0045132)3.45605267
26DNA double-strand break processing (GO:0000729)3.44764070
27startle response (GO:0001964)3.40736940
28V(D)J recombination (GO:0033151)3.39029627
29synaptic transmission, glutamatergic (GO:0035249)3.34965971
30mitotic G2/M transition checkpoint (GO:0044818)3.34360429
31L-amino acid import (GO:0043092)3.33715828
32positive regulation of histone H3-K4 methylation (GO:0051571)3.32543126
33attachment of spindle microtubules to kinetochore (GO:0008608)3.32292574
34somatic diversification of immune receptors (GO:0002200)3.30961680
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.27981912
36isotype switching (GO:0045190)3.27981912
37somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.27981912
38neuron-neuron synaptic transmission (GO:0007270)3.27499213
39sister chromatid cohesion (GO:0007062)3.25091001
40negative regulation of neurotransmitter transport (GO:0051589)3.24773584
41neuronal action potential propagation (GO:0019227)3.24589721
42resolution of meiotic recombination intermediates (GO:0000712)3.23433093
43regulation of mitotic spindle checkpoint (GO:1903504)3.22186897
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22186897
45regulation of helicase activity (GO:0051095)3.20577549
46somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.20348112
47somatic cell DNA recombination (GO:0016444)3.20348112
48nuclear pore organization (GO:0006999)3.19572870
49telomere maintenance via telomerase (GO:0007004)3.19204282
50double-strand break repair via nonhomologous end joining (GO:0006303)3.16873952
51non-recombinational repair (GO:0000726)3.16873952
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16847241
53somatic diversification of immunoglobulins (GO:0016445)3.16131636
54long-chain fatty acid biosynthetic process (GO:0042759)3.13281341
55mitotic G2 DNA damage checkpoint (GO:0007095)3.12946287
56negative regulation of DNA recombination (GO:0045910)3.10073633
57regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.09638571
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09275859
59DNA catabolic process, exonucleolytic (GO:0000738)3.08621788
60CENP-A containing nucleosome assembly (GO:0034080)3.07666430
61chromatin remodeling at centromere (GO:0031055)3.06720759
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.06569675
63double-strand break repair via homologous recombination (GO:0000724)3.06556615
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.03800286
65regulation of pigment cell differentiation (GO:0050932)3.03201008
66transmission of nerve impulse (GO:0019226)3.03061217
67recombinational repair (GO:0000725)3.02446695
68reciprocal DNA recombination (GO:0035825)3.01473200
69reciprocal meiotic recombination (GO:0007131)3.01473200
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00139096
71somatic recombination of immunoglobulin gene segments (GO:0016447)2.98969121
72nuclear pore complex assembly (GO:0051292)2.97447497
73postreplication repair (GO:0006301)2.97447170
74histone mRNA catabolic process (GO:0071044)2.96450587
75postsynaptic membrane organization (GO:0001941)2.95704910
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95525549
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95509383
78centriole assembly (GO:0098534)2.94539258
79B cell receptor signaling pathway (GO:0050853)2.93789110
80cerebral cortex radially oriented cell migration (GO:0021799)2.92861929
81proteasome assembly (GO:0043248)2.91862550
82limb bud formation (GO:0060174)2.91611280
83maturation of 5.8S rRNA (GO:0000460)2.91356484
84chromosome organization involved in meiosis (GO:0070192)2.90657012
85preassembly of GPI anchor in ER membrane (GO:0016254)2.88257760
86replicative senescence (GO:0090399)2.88114826
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87513298
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.87513298
89neuron recognition (GO:0008038)2.86560321
90piRNA metabolic process (GO:0034587)2.86144886
91mismatch repair (GO:0006298)2.83511257
92histone mRNA metabolic process (GO:0008334)2.83179217
93rRNA catabolic process (GO:0016075)2.82732528
94protein localization to synapse (GO:0035418)2.82013035
95DNA topological change (GO:0006265)2.81696168
96cyclic nucleotide catabolic process (GO:0009214)2.79426406
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78909227
98DNA deamination (GO:0045006)2.77508694
99DNA replication checkpoint (GO:0000076)2.76324500
100transcription elongation from RNA polymerase I promoter (GO:0006362)2.75449721
101meiotic cell cycle (GO:0051321)2.75078671
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74360185
103kinetochore organization (GO:0051383)2.73335532
104long-term synaptic potentiation (GO:0060291)2.73164304
105developmental pigmentation (GO:0048066)2.72818792
106neural tube formation (GO:0001841)2.72747375
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72720371
108DNA-dependent DNA replication (GO:0006261)2.71669528
109negative regulation of neurotransmitter secretion (GO:0046929)2.70970813
110regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70930163
111regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70060895
112histone exchange (GO:0043486)2.69051139
113DNA recombination (GO:0006310)2.68719879
114RNA-dependent DNA replication (GO:0006278)2.67930219
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.67419799
116retina layer formation (GO:0010842)2.65616732
117double-strand break repair (GO:0006302)2.65303850
118mRNA splice site selection (GO:0006376)2.65245361
119regulation of respiratory system process (GO:0044065)2.65131445
120DNA synthesis involved in DNA repair (GO:0000731)2.64755326
121response to histamine (GO:0034776)2.64091391
122vocalization behavior (GO:0071625)2.62495261
123regulation of postsynaptic membrane potential (GO:0060078)2.61612860
124axonal fasciculation (GO:0007413)2.59101353
125telomere maintenance (GO:0000723)2.58659017
126neurotransmitter uptake (GO:0001504)2.58629070
127DNA replication-dependent nucleosome organization (GO:0034723)2.58459138
128DNA replication-dependent nucleosome assembly (GO:0006335)2.58459138
129regulation of centriole replication (GO:0046599)2.57977707
130cAMP catabolic process (GO:0006198)2.57550145
131mitochondrial DNA replication (GO:0006264)2.57143256
132termination of RNA polymerase I transcription (GO:0006363)2.56690979
133detection of calcium ion (GO:0005513)2.56245004
134mechanosensory behavior (GO:0007638)2.55850658
135regulation of B cell receptor signaling pathway (GO:0050855)2.55369443
136telomere organization (GO:0032200)2.55005825
137cerebellar Purkinje cell differentiation (GO:0021702)2.54653974
138positive regulation of B cell differentiation (GO:0045579)2.54559767
139DNA methylation involved in gamete generation (GO:0043046)2.54160915
140GPI anchor metabolic process (GO:0006505)2.53341017
141myelination (GO:0042552)2.52863440
142spermatid nucleus differentiation (GO:0007289)2.52764776
143meiotic cell cycle process (GO:1903046)2.51855740
144mitotic recombination (GO:0006312)2.51018861
145protein localization to cilium (GO:0061512)2.50543939
146mitotic nuclear envelope disassembly (GO:0007077)2.49733236
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49248172
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49248172
149nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.49194542
150protein K11-linked deubiquitination (GO:0035871)2.48838684
151sleep (GO:0030431)2.48444669
152positive regulation of histone methylation (GO:0031062)2.48442961
153mitotic spindle checkpoint (GO:0071174)2.47651100
154single strand break repair (GO:0000012)2.47452592
155telomere maintenance via recombination (GO:0000722)2.47089568
156regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46483730
157long-term memory (GO:0007616)2.45723718
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42658760
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.42658760
160regulation of translation, ncRNA-mediated (GO:0045974)2.42658760
161cellular response to interleukin-15 (GO:0071350)2.42041900
162axon ensheathment (GO:0008366)2.41835437
163ensheathment of neurons (GO:0007272)2.41835437
164positive regulation of synapse assembly (GO:0051965)2.41571663
165GPI anchor biosynthetic process (GO:0006506)2.40210480
166activated T cell proliferation (GO:0050798)2.39689209
167righting reflex (GO:0060013)2.38953125
168regulation of respiratory gaseous exchange (GO:0043576)2.38925148
169calcium ion import (GO:0070509)2.38836546
170response to redox state (GO:0051775)2.38600748
171membrane depolarization (GO:0051899)2.35195160
172amino acid import (GO:0043090)2.34198297
173regulation of vesicle fusion (GO:0031338)2.33088411
174regulation of neuron projection regeneration (GO:0070570)2.33019488
175regulation of axon regeneration (GO:0048679)2.33019488
176regulation of rhodopsin mediated signaling pathway (GO:0022400)2.32568431
177positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.31453121
178retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31303109
179regulation of glutamate receptor signaling pathway (GO:1900449)2.31108540
180protein targeting to Golgi (GO:0000042)2.30987306
181eye photoreceptor cell differentiation (GO:0001754)2.30482303
182photoreceptor cell differentiation (GO:0046530)2.30482303
183negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.30198305
184regulation of synapse assembly (GO:0051963)2.27580642
185regulation of inositol phosphate biosynthetic process (GO:0010919)2.25972185
186adult walking behavior (GO:0007628)2.25652092
187positive regulation of granulocyte differentiation (GO:0030854)2.25610799
188rhodopsin mediated signaling pathway (GO:0016056)2.25568878
189positive regulation of action potential (GO:0045760)2.25490976
190negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24587986
191negative regulation of cell killing (GO:0031342)2.24587986
192peptidyl-lysine trimethylation (GO:0018023)2.23342584
193response to epinephrine (GO:0071871)2.20971049
194membrane depolarization during action potential (GO:0086010)2.20881251
195neuron remodeling (GO:0016322)2.20833476
196regulation of catecholamine metabolic process (GO:0042069)2.20781843
197regulation of dopamine metabolic process (GO:0042053)2.20781843
198positive regulation of membrane potential (GO:0045838)2.20540994
199dentate gyrus development (GO:0021542)2.20001848
200negative regulation of protein localization to cell surface (GO:2000009)2.19923686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.16245582
2E2F7_22180533_ChIP-Seq_HELA_Human4.01205611
3EZH2_22144423_ChIP-Seq_EOC_Human3.87420081
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.58013590
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23636883
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20945160
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.97769321
8TAF15_26573619_Chip-Seq_HEK293_Human2.90957495
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.85770462
10ELK1_19687146_ChIP-ChIP_HELA_Human2.72679572
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60941612
12ZNF274_21170338_ChIP-Seq_K562_Hela2.54525421
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.53996679
14VDR_23849224_ChIP-Seq_CD4+_Human2.53224996
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46128710
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41243333
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27548699
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.24311285
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23878876
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22084905
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12604981
22AR_21572438_ChIP-Seq_LNCaP_Human2.10377828
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09961110
24* P300_19829295_ChIP-Seq_ESCs_Human2.08656396
25FOXP3_21729870_ChIP-Seq_TREG_Human2.08133466
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.08097375
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05599972
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01219125
29FUS_26573619_Chip-Seq_HEK293_Human2.00831678
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00591625
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98585919
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94880328
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94819445
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92635393
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91818493
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.88155184
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87775577
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87654333
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87459928
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87205480
41* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86432758
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86153819
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85212408
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83683663
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.80317520
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78458348
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78075835
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.77689825
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77385392
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76423481
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74322894
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74198775
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.73657481
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.72334249
55VDR_22108803_ChIP-Seq_LS180_Human1.71977072
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.69229267
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.69110168
58* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69055371
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.67748876
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63427898
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62285449
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61454327
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61333643
64MYC_18940864_ChIP-ChIP_HL60_Human1.61224155
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.60983256
66ER_23166858_ChIP-Seq_MCF-7_Human1.60637187
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60364467
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60002112
69IGF1R_20145208_ChIP-Seq_DFB_Human1.58913956
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58296189
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57718834
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.55570810
73DROSHA_22980978_ChIP-Seq_HELA_Human1.54041640
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51891519
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51891519
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.50692937
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50602092
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50247503
79EWS_26573619_Chip-Seq_HEK293_Human1.49536978
80P53_22387025_ChIP-Seq_ESCs_Mouse1.48156858
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47438824
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.47066603
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.46965895
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46586976
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46479033
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.46235573
87* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45717134
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.45678363
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45651731
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44952836
91* STAT3_23295773_ChIP-Seq_U87_Human1.44719433
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.40517860
93IRF1_19129219_ChIP-ChIP_H3396_Human1.40356703
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39869498
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39509956
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38636989
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38424427
98* TCF4_23295773_ChIP-Seq_U87_Human1.38304425
99TP53_16413492_ChIP-PET_HCT116_Human1.36999444
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36695895
101P300_18555785_Chip-Seq_ESCs_Mouse1.36127971
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33712817
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33476343
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.32750476
105* E2F1_21310950_ChIP-Seq_MCF-7_Human1.32744547
106RNF2_27304074_Chip-Seq_NSC_Mouse1.31453397
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30123883
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.29510410
109CIITA_25753668_ChIP-Seq_RAJI_Human1.29431377
110* TAL1_26923725_Chip-Seq_HPCs_Mouse1.29049255
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.28454204
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.28171634
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28156178
114* REST_21632747_ChIP-Seq_MESCs_Mouse1.27272903
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.26700039
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.26031945
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.25802468
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25640525
119MYB_26560356_Chip-Seq_TH2_Human1.25020193
120* AR_25329375_ChIP-Seq_VCAP_Human1.23459504
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23059676
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22763490
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22763490
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.22606587
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22504607
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21839939
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.21722960
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21508013
129MYC_18555785_ChIP-Seq_MESCs_Mouse1.20060998
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18449240
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18145995
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17981561
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17277732
134AHR_22903824_ChIP-Seq_MCF-7_Human1.17217031
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17127495
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15858331
137LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15083651
138KDM2B_26808549_Chip-Seq_REH_Human1.14424816
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14207648
140CBP_20019798_ChIP-Seq_JUKART_Human1.13623202
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13623202
142TP53_18474530_ChIP-ChIP_U2OS_Human1.13566500
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13535299
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13017069
145IRF8_21731497_ChIP-ChIP_J774_Mouse1.12388105
146PU1_27457419_Chip-Seq_LIVER_Mouse1.12048777
147NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11331180
148DCP1A_22483619_ChIP-Seq_HELA_Human1.08915906
149GATA3_26560356_Chip-Seq_TH2_Human1.08625189
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05609040
151* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05154148
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04999441
153TP63_19390658_ChIP-ChIP_HaCaT_Human1.03541137
154SALL4_22934838_ChIP-ChIP_CD34+_Human1.01758640
155TP53_22573176_ChIP-Seq_HFKS_Human1.00673351
156MYB_26560356_Chip-Seq_TH1_Human0.98840931
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97847414
158GABP_19822575_ChIP-Seq_HepG2_Human0.96749214
159* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95972563
160BCAT_22108803_ChIP-Seq_LS180_Human0.95261672
161STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95245677
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94459332
163FOXA1_25329375_ChIP-Seq_VCAP_Human0.94459332
164GATA3_26560356_Chip-Seq_TH1_Human0.94015263
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93924796
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93787442
167SOX2_19829295_ChIP-Seq_ESCs_Human0.92234449
168NANOG_19829295_ChIP-Seq_ESCs_Human0.92234449
169* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91562042
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.89027779
171HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88536962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.19766385
2MP0003880_abnormal_central_pattern4.75484094
3MP0008058_abnormal_DNA_repair4.36950157
4MP0010094_abnormal_chromosome_stability4.18672038
5MP0005409_darkened_coat_color3.16821888
6MP0002138_abnormal_hepatobiliary_system2.95296851
7MP0001188_hyperpigmentation2.83530600
8MP0004859_abnormal_synaptic_plasticity2.78898747
9MP0009697_abnormal_copulation2.69813874
10MP0000566_synostosis2.64755671
11MP0003718_maternal_effect2.64233232
12MP0009745_abnormal_behavioral_response2.60069627
13MP0006292_abnormal_olfactory_placode2.50308348
14MP0003693_abnormal_embryo_hatching2.48260078
15MP0003635_abnormal_synaptic_transmissio2.46076615
16MP0001486_abnormal_startle_reflex2.43682567
17MP0002396_abnormal_hematopoietic_system2.36955026
18MP0002272_abnormal_nervous_system2.36560998
19MP0002064_seizures2.35023459
20MP0005423_abnormal_somatic_nervous2.34215462
21MP0003077_abnormal_cell_cycle2.34129668
22MP0003111_abnormal_nucleus_morphology2.29008424
23MP0002166_altered_tumor_susceptibility2.28931472
24MP0002572_abnormal_emotion/affect_behav2.26979902
25MP0004270_analgesia2.20184089
26MP0009046_muscle_twitch2.13047305
27MP0001501_abnormal_sleep_pattern2.11994317
28MP0005646_abnormal_pituitary_gland2.11463504
29MP0005171_absent_coat_pigmentation2.09600559
30MP0003787_abnormal_imprinting2.05952926
31MP0002063_abnormal_learning/memory/cond2.02211726
32MP0000920_abnormal_myelination2.00508872
33MP0004957_abnormal_blastocyst_morpholog1.96276099
34MP0002006_tumorigenesis1.95616845
35MP0005645_abnormal_hypothalamus_physiol1.94848337
36MP0005551_abnormal_eye_electrophysiolog1.86918985
37MP0001968_abnormal_touch/_nociception1.85408575
38MP0004381_abnormal_hair_follicle1.80752941
39MP0003136_yellow_coat_color1.80566167
40MP0002735_abnormal_chemical_nociception1.76388752
41MP0001800_abnormal_humoral_immune1.75629210
42MP0001529_abnormal_vocalization1.73688272
43MP0001905_abnormal_dopamine_level1.71544883
44MP0004742_abnormal_vestibular_system1.69732385
45MP0002067_abnormal_sensory_capabilities1.67195644
46MP0004142_abnormal_muscle_tone1.65234815
47MP0008007_abnormal_cellular_replicative1.63129592
48MP0003890_abnormal_embryonic-extraembry1.61164850
49MP0001984_abnormal_olfaction1.59379218
50MP0001440_abnormal_grooming_behavior1.59278146
51MP0003786_premature_aging1.59025906
52MP0000685_abnormal_immune_system1.57395019
53MP0002822_catalepsy1.54010389
54MP0002736_abnormal_nociception_after1.53736221
55MP0003183_abnormal_peptide_metabolism1.51681585
56MP0001502_abnormal_circadian_rhythm1.50278696
57MP0001929_abnormal_gametogenesis1.50271101
58MP0006276_abnormal_autonomic_nervous1.49616489
59MP0002734_abnormal_mechanical_nocicepti1.46977545
60MP0000689_abnormal_spleen_morphology1.46899583
61MP0002398_abnormal_bone_marrow1.46801081
62MP0000015_abnormal_ear_pigmentation1.45771574
63MP0000778_abnormal_nervous_system1.42977808
64MP0004808_abnormal_hematopoietic_stem1.41337986
65MP0008877_abnormal_DNA_methylation1.39823893
66MP0005379_endocrine/exocrine_gland_phen1.38777782
67MP0008569_lethality_at_weaning1.38684590
68MP0004885_abnormal_endolymph1.36297268
69MP0002876_abnormal_thyroid_physiology1.36056377
70MP0002210_abnormal_sex_determination1.34986654
71MP0002009_preneoplasia1.34699160
72MP0008995_early_reproductive_senescence1.33986019
73MP0001986_abnormal_taste_sensitivity1.31382395
74MP0009780_abnormal_chondrocyte_physiolo1.31106388
75MP0002019_abnormal_tumor_incidence1.29824193
76MP0006054_spinal_hemorrhage1.29189460
77MP0004924_abnormal_behavior1.28032759
78MP0005386_behavior/neurological_phenoty1.28032759
79MP0005075_abnormal_melanosome_morpholog1.25851958
80MP0000703_abnormal_thymus_morphology1.25356594
81MP0002557_abnormal_social/conspecific_i1.25055482
82MP0002452_abnormal_antigen_presenting1.22974121
83MP0005174_abnormal_tail_pigmentation1.21407407
84MP0001970_abnormal_pain_threshold1.20517614
85MP0001485_abnormal_pinna_reflex1.18674488
86MP0006072_abnormal_retinal_apoptosis1.17042957
87MP0002722_abnormal_immune_system1.16791435
88MP0002420_abnormal_adaptive_immunity1.16085436
89MP0004147_increased_porphyrin_level1.15239510
90MP0010307_abnormal_tumor_latency1.14172455
91MP0000653_abnormal_sex_gland1.13524769
92MP0005389_reproductive_system_phenotype1.12687349
93MP0000716_abnormal_immune_system1.12394811
94MP0001819_abnormal_immune_cell1.11285735
95MP0001963_abnormal_hearing_physiology1.10369540
96MP0002229_neurodegeneration1.10136999
97MP0005671_abnormal_response_to1.09642463
98MP0005000_abnormal_immune_tolerance1.09494227
99MP0002723_abnormal_immune_serum1.09415022
100MP0001145_abnormal_male_reproductive1.06164282
101MP0000383_abnormal_hair_follicle1.05489382
102MP0002160_abnormal_reproductive_system1.05235819
103MP0002882_abnormal_neuron_morphology1.04447624
104MP0001764_abnormal_homeostasis1.04199219
105MP0003121_genomic_imprinting1.01086356
106MP0005253_abnormal_eye_physiology0.99801179
107MP0002184_abnormal_innervation0.99633015
108MP0001119_abnormal_female_reproductive0.99465692
109MP0002095_abnormal_skin_pigmentation0.98092825
110MP0005310_abnormal_salivary_gland0.97790131
111MP0002751_abnormal_autonomic_nervous0.97512354
112MP0003698_abnormal_male_reproductive0.97247603
113MP0000631_abnormal_neuroendocrine_gland0.95743240
114MP0008932_abnormal_embryonic_tissue0.94143851
115MP0004145_abnormal_muscle_electrophysio0.94068863
116MP0002429_abnormal_blood_cell0.93986960
117MP0010386_abnormal_urinary_bladder0.93575665
118MP0004134_abnormal_chest_morphology0.93461050
119MP0002733_abnormal_thermal_nociception0.92583025
120MP0000569_abnormal_digit_pigmentation0.92549237
121MP0003631_nervous_system_phenotype0.91498908
122MP0005410_abnormal_fertilization0.91472254
123MP0000313_abnormal_cell_death0.90339224
124MP0000026_abnormal_inner_ear0.90250376
125MP0000427_abnormal_hair_cycle0.89931833
126MP0005395_other_phenotype0.89722452
127MP0003633_abnormal_nervous_system0.89139009
128MP0001919_abnormal_reproductive_system0.89055723
129MP0002066_abnormal_motor_capabilities/c0.88452272
130MP0000350_abnormal_cell_proliferation0.87953739
131MP0005220_abnormal_exocrine_pancreas0.87804034
132MP0006035_abnormal_mitochondrial_morpho0.87054812
133MP0000955_abnormal_spinal_cord0.85266067
134MP0003879_abnormal_hair_cell0.84316285
135MP0002163_abnormal_gland_morphology0.84115348
136MP0002102_abnormal_ear_morphology0.83251381
137MP0002752_abnormal_somatic_nervous0.82371103
138MP0002638_abnormal_pupillary_reflex0.82162871
139MP0005266_abnormal_metabolism0.80135557
140MP0002277_abnormal_respiratory_mucosa0.80074582
141MP0001697_abnormal_embryo_size0.78778248
142MP0006036_abnormal_mitochondrial_physio0.78475194
143MP0000465_gastrointestinal_hemorrhage0.78410208
144MP0002938_white_spotting0.78178734
145MP0009379_abnormal_foot_pigmentation0.77852175
146MP0005387_immune_system_phenotype0.77704986
147MP0001790_abnormal_immune_system0.77704986
148MP0000647_abnormal_sebaceous_gland0.77535627
149MP0005084_abnormal_gallbladder_morpholo0.77081635
150MP0002148_abnormal_hypersensitivity_rea0.75332317
151MP0003699_abnormal_female_reproductive0.75020407
152MP0003763_abnormal_thymus_physiology0.75006854
153MP0003186_abnormal_redox_activity0.74792616
154MP0001835_abnormal_antigen_presentation0.74674565
155MP0003632_abnormal_nervous_system0.74450452
156MP0003690_abnormal_glial_cell0.73816619
157MP0001177_atelectasis0.73544275
158MP0001672_abnormal_embryogenesis/_devel0.72778397
159MP0005380_embryogenesis_phenotype0.72778397
160MP0003221_abnormal_cardiomyocyte_apopto0.72540755
161MP0003567_abnormal_fetal_cardiomyocyte0.72092327
162MP0001730_embryonic_growth_arrest0.71580686
163MP0000579_abnormal_nail_morphology0.71414045
164MP0001873_stomach_inflammation0.71262552
165MP0003938_abnormal_ear_development0.71127643
166MP0005195_abnormal_posterior_eye0.70270739
167MP0000372_irregular_coat_pigmentation0.69719299
168MP0008789_abnormal_olfactory_epithelium0.69077100
169MP0003806_abnormal_nucleotide_metabolis0.68417053
170MP0010678_abnormal_skin_adnexa0.68137263
171MP0003045_fibrosis0.68085630
172MP0002234_abnormal_pharynx_morphology0.67518746
173MP0000613_abnormal_salivary_gland0.67342142

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.98844468
2B lymphocytopenia (HP:0010976)4.33893167
3Abnormal hair whorl (HP:0010721)4.19061105
4Abnormality of B cell number (HP:0010975)4.16449096
5Thyroiditis (HP:0100646)3.82247574
6Febrile seizures (HP:0002373)3.81824952
7Severe combined immunodeficiency (HP:0004430)3.67365074
8Epileptic encephalopathy (HP:0200134)3.51704469
9Volvulus (HP:0002580)3.43371182
10Combined immunodeficiency (HP:0005387)3.34013484
11Pancreatic cysts (HP:0001737)3.22376665
12Abnormality of chromosome stability (HP:0003220)3.20134288
13Broad-based gait (HP:0002136)3.05783576
14Abnormality of incisor morphology (HP:0011063)3.03685363
15Colon cancer (HP:0003003)3.02539895
16Chromsome breakage (HP:0040012)2.97909210
17Protruding tongue (HP:0010808)2.96543540
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93794412
19Hyperventilation (HP:0002883)2.93161128
20Hypoproteinemia (HP:0003075)2.88283977
21Abnormality of the columella (HP:0009929)2.85117205
22Atonic seizures (HP:0010819)2.84287697
23Hypoplasia of the thymus (HP:0000778)2.81349334
24Lip pit (HP:0100267)2.76402653
25Fair hair (HP:0002286)2.75768951
26Focal seizures (HP:0007359)2.73932744
27Generalized hypopigmentation of hair (HP:0011358)2.66209113
28Abnormal biliary tract physiology (HP:0012439)2.65378937
29Bile duct proliferation (HP:0001408)2.65378937
30Absent/shortened dynein arms (HP:0200106)2.62755176
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.62755176
32Medial flaring of the eyebrow (HP:0010747)2.62495999
33Widely spaced teeth (HP:0000687)2.58800976
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.58123490
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58123490
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.55940309
37Cupped ear (HP:0000378)2.54248958
38Aplasia cutis congenita (HP:0001057)2.49684481
39Abnormality of DNA repair (HP:0003254)2.44680885
40Nasolacrimal duct obstruction (HP:0000579)2.41286032
41White forelock (HP:0002211)2.40881396
42Meckel diverticulum (HP:0002245)2.39982049
43Absent speech (HP:0001344)2.38622285
44Agammaglobulinemia (HP:0004432)2.37297637
45IgG deficiency (HP:0004315)2.36929199
46T lymphocytopenia (HP:0005403)2.36317309
47Alacrima (HP:0000522)2.36064988
48Blue irides (HP:0000635)2.35673090
49Drooling (HP:0002307)2.32859015
50Excessive salivation (HP:0003781)2.32859015
51Gaze-evoked nystagmus (HP:0000640)2.29954002
52Abnormality of T cell number (HP:0011839)2.28115961
53Abnormality of the ileum (HP:0001549)2.27633930
54Patchy hypopigmentation of hair (HP:0011365)2.27465789
55Myelodysplasia (HP:0002863)2.26090298
56Gait imbalance (HP:0002141)2.25289296
57Dialeptic seizures (HP:0011146)2.24328292
58Abnormality of salivation (HP:0100755)2.23155406
59Clubbing of toes (HP:0100760)2.22431150
60Progressive cerebellar ataxia (HP:0002073)2.21814702
61Abnormality of the preputium (HP:0100587)2.19893057
62Abnormality of the prostate (HP:0008775)2.19689458
63Scanning speech (HP:0002168)2.18468117
64Eosinophilia (HP:0001880)2.17617351
65Renal cortical cysts (HP:0000803)2.17117449
66Abnormality of the nasal septum (HP:0000419)2.16922181
67Decreased lacrimation (HP:0000633)2.16647659
68Abnormal ciliary motility (HP:0012262)2.16441812
69Congenital primary aphakia (HP:0007707)2.16361583
70Chronic sinusitis (HP:0011109)2.15813561
71Abnormality of the renal cortex (HP:0011035)2.15436060
72Sloping forehead (HP:0000340)2.15367003
73Aplasia involving bones of the upper limbs (HP:0009823)2.12922201
74Aplasia of the phalanges of the hand (HP:0009802)2.12922201
75Aplasia involving bones of the extremities (HP:0009825)2.12922201
76Abnormality of the nasolacrimal system (HP:0000614)2.12891842
77Small intestinal stenosis (HP:0012848)2.12368700
78Duodenal stenosis (HP:0100867)2.12368700
79Prostate neoplasm (HP:0100787)2.11969917
80Nephrogenic diabetes insipidus (HP:0009806)2.11749181
81Recurrent bronchitis (HP:0002837)2.11639077
82Neoplasm of the adrenal cortex (HP:0100641)2.09699133
83Chronic hepatic failure (HP:0100626)2.08305514
84Neoplasm of the oral cavity (HP:0100649)2.08222511
85Truncal ataxia (HP:0002078)2.08059916
86Stomach cancer (HP:0012126)2.06246605
87Supernumerary spleens (HP:0009799)2.06012932
88Medulloblastoma (HP:0002885)2.04917451
89Genital tract atresia (HP:0001827)2.04302009
90Xerostomia (HP:0000217)2.03748188
91Lymphoma (HP:0002665)2.03029431
92Abnormality of the lacrimal duct (HP:0011481)2.02930896
93Clumsiness (HP:0002312)2.02877306
94Aplastic anemia (HP:0001915)2.02570884
95Conical tooth (HP:0000698)2.02527725
96Recurrent viral infections (HP:0004429)2.02512978
97Decreased central vision (HP:0007663)2.01729823
98Panhypogammaglobulinemia (HP:0003139)2.01322152
99Progressive macrocephaly (HP:0004481)2.00937414
100Dry hair (HP:0011359)2.00498266
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00304907
102Rhabdomyosarcoma (HP:0002859)1.99684572
103Absence seizures (HP:0002121)1.98409472
104Increased hepatocellular lipid droplets (HP:0006565)1.98349771
105Vaginal atresia (HP:0000148)1.97878257
106Limb hypertonia (HP:0002509)1.97441226
107Poikiloderma (HP:0001029)1.96960462
108Abnormality of T cells (HP:0002843)1.96783311
109Abnormality of eosinophils (HP:0001879)1.96526149
110Methylmalonic acidemia (HP:0002912)1.96305810
111Poor coordination (HP:0002370)1.96097953
112Abnormality of the axillary hair (HP:0100134)1.95245806
113Abnormality of secondary sexual hair (HP:0009888)1.95245806
114Abnormality of the fingertips (HP:0001211)1.95046220
115Diplopia (HP:0000651)1.94923148
116Abnormality of binocular vision (HP:0011514)1.94923148
117Abnormal delayed hypersensitivity skin test (HP:0002963)1.94293215
118True hermaphroditism (HP:0010459)1.94234974
119Abnormality of the parietal bone (HP:0002696)1.92289088
120Hypothermia (HP:0002045)1.91404516
121Parakeratosis (HP:0001036)1.91210273
122Abnormality of the right ventricle (HP:0001707)1.90986870
123Increased CSF lactate (HP:0002490)1.90682695
124Gonadotropin excess (HP:0000837)1.89862184
125Abnormality of midbrain morphology (HP:0002418)1.88374106
126Molar tooth sign on MRI (HP:0002419)1.88374106
127IgM deficiency (HP:0002850)1.87777447
128Meningitis (HP:0001287)1.87758676
129Anteriorly placed anus (HP:0001545)1.87173868
130Neutropenia (HP:0001875)1.86848251
131Abnormality of the renal medulla (HP:0100957)1.85930688
132Gastroesophageal reflux (HP:0002020)1.84617597
133Acute necrotizing encephalopathy (HP:0006965)1.83753138
134Abnormal respiratory epithelium morphology (HP:0012253)1.82336112
135Abnormal respiratory motile cilium morphology (HP:0005938)1.82336112
136Pancreatic fibrosis (HP:0100732)1.82084072
137Abnormal respiratory motile cilium physiology (HP:0012261)1.82012976
138Verrucae (HP:0200043)1.81644656
139Papilloma (HP:0012740)1.81644656
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.81333947
141Congenital stationary night blindness (HP:0007642)1.81100130
142Nephronophthisis (HP:0000090)1.80915286
143Dysmetria (HP:0001310)1.80570951
144Intestinal atresia (HP:0011100)1.80497605
145Abnormality of the labia minora (HP:0012880)1.80377856
146Abnormality of the duodenum (HP:0002246)1.79540637
147Acute encephalopathy (HP:0006846)1.79076621
148Congenital, generalized hypertrichosis (HP:0004540)1.78656896
149Lipid accumulation in hepatocytes (HP:0006561)1.78266651
150Hemiparesis (HP:0001269)1.78182070
151Recurrent cutaneous fungal infections (HP:0011370)1.76570911
152Chronic mucocutaneous candidiasis (HP:0002728)1.76570911
153Retinal dysplasia (HP:0007973)1.76137281
154Abnormality of the incisor (HP:0000676)1.74884674
155Slow saccadic eye movements (HP:0000514)1.74724966
156Tubulointerstitial nephritis (HP:0001970)1.74479202
157Mixed hearing impairment (HP:0000410)1.74184432
158Acute lymphatic leukemia (HP:0006721)1.73496927
159Mitochondrial inheritance (HP:0001427)1.72255606
160Oculomotor apraxia (HP:0000657)1.71757799
161Flat occiput (HP:0005469)1.70520675
162Muscle hypertrophy of the lower extremities (HP:0008968)1.70359157
163Oligodactyly (hands) (HP:0001180)1.69752318
164Decreased circulating renin level (HP:0003351)1.69618932
165Granulocytopenia (HP:0001913)1.69056207
166Acute myeloid leukemia (HP:0004808)1.68269658
167Submucous cleft hard palate (HP:0000176)1.66657298
168Generalized tonic-clonic seizures (HP:0002069)1.66106662
169Tented upper lip vermilion (HP:0010804)1.64468451
170Duplicated collecting system (HP:0000081)1.63929969
171Exotropia (HP:0000577)1.63648836
172Glioma (HP:0009733)1.62461614
173Preaxial hand polydactyly (HP:0001177)1.62393579
174Median cleft lip (HP:0000161)1.61648074
175Abnormal glycosylation (HP:0012345)1.61626235
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61626235
177Abnormal protein N-linked glycosylation (HP:0012347)1.61626235
178Abnormal protein glycosylation (HP:0012346)1.61626235
179Partial duplication of thumb phalanx (HP:0009944)1.61242814
180Aplasia/Hypoplasia of the tibia (HP:0005772)1.61136797
181Abnormality of the corticospinal tract (HP:0002492)1.60232900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.83812876
2EIF2AK33.80653348
3CASK3.67175124
4FRK3.58531915
5NTRK32.83971976
6EPHA42.60031871
7MAP4K22.56232750
8INSRR2.33386661
9MAP2K72.32961429
10RIPK42.14992183
11EIF2AK12.01085951
12PLK41.96426192
13TTK1.95055045
14MAPK131.93976524
15NEK61.81676600
16TXK1.81496058
17BMPR21.71031746
18PLK31.66875938
19OXSR11.66184607
20STK391.66010283
21TRIM281.65968252
22CDC71.62378452
23NEK11.57782965
24GRK71.55142916
25BMPR1B1.51679569
26FES1.48980422
27MAPKAPK51.47628194
28BUB11.47040877
29STK31.37520261
30PKN11.36365972
31TAF11.35623527
32MST41.34259879
33PNCK1.33795746
34CDK91.32797826
35MAP3K41.32032115
36SIK31.31059278
37YES11.30635211
38WNK31.30173520
39CDK31.26949137
40MAP3K141.26280698
41MAP3K131.24019562
42CAMK1G1.22574594
43NUAK11.21787654
44ACVR1B1.20667238
45PRPF4B1.19143804
46MAP3K101.18391782
47BRD41.18149292
48TGFBR11.18017002
49PLK21.16158370
50SIK21.15657756
51VRK21.14286951
52STK241.13872156
53STK161.13773644
54ADRBK21.12847052
55TLK11.10925299
56CLK11.10761362
57PBK1.09069964
58MAPK151.08992141
59ATR1.08937035
60TNK21.07978329
61NLK1.07841394
62ERBB31.05971124
63BCR1.01363139
64BRSK21.01052319
65MARK21.00244087
66FGFR20.99467244
67PRKCQ0.97741444
68FLT30.95747434
69CDK80.94912849
70MAPK70.90719857
71CCNB10.89984615
72MAP3K60.89315750
73WNK10.89284276
74AKT30.88529368
75ATM0.87650996
76CAMK2B0.87339278
77IRAK40.86793593
78MKNK10.85952095
79PLK10.85503936
80SGK4940.85330603
81SGK2230.85330603
82PRKCE0.85245249
83CDK190.85032483
84WEE10.84978448
85SGK20.83301429
86MKNK20.83068285
87PIM10.82363371
88STK38L0.82238992
89PIK3CA0.82044919
90MAP3K120.81368879
91TEC0.79514908
92SYK0.78080310
93IRAK30.77605967
94CAMK2A0.77552373
95MAPK120.77116456
96PRKCI0.76769951
97SGK10.76330838
98NME10.76054376
99NTRK20.75157586
100TAOK30.74855490
101CHEK20.74407635
102FGR0.72255119
103MARK30.70856287
104DYRK30.70467037
105MUSK0.69985062
106IKBKE0.69956100
107ZAK0.69709967
108NEK20.69260497
109PIK3CG0.67539049
110CAMK1D0.66727150
111BTK0.66530920
112CDK60.65391972
113CAMK10.64949303
114CAMK2D0.64943507
115LCK0.64596361
116CDK50.61746569
117CHEK10.61655966
118CDC42BPA0.61346334
119LYN0.60803100
120TSSK60.60683780
121GRK50.59911623
122AURKB0.58876168
123TRPM70.58823311
124MAP2K40.58801901
125STK40.58012397
126VRK10.57166622
127EIF2AK20.55364286
128MAP4K10.54738032
129PRKG10.54694528
130ITK0.53765278
131SRPK10.53508409
132KIT0.52774203
133DYRK1A0.50860869
134RPS6KA40.49847871
135JAK10.49707278
136CSNK1G10.49381735
137GRK10.48833929
138EPHB10.47043775
139IKBKB0.46674909
140FGFR30.46542701
141CDK40.44987069
142RPS6KB20.44672587
143CSNK2A20.44028510
144HIPK20.43701693
145BLK0.41706980
146RAF10.41090875
147UHMK10.40510006
148STK100.40352568
149PRKD20.39623443
150RPS6KA50.39494679
151CSF1R0.39397366
152ROCK20.39143955
153FYN0.37877537
154PRKACA0.37272502
155CDK20.36952431
156MAP2K60.36335610
157CSNK2A10.34170838

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.85377602
2Nicotine addiction_Homo sapiens_hsa050333.64690570
3Homologous recombination_Homo sapiens_hsa034403.18410888
4Mismatch repair_Homo sapiens_hsa034303.04339417
5Basal transcription factors_Homo sapiens_hsa030222.77665302
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76727090
7Proteasome_Homo sapiens_hsa030502.68182031
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63522099
9Glutamatergic synapse_Homo sapiens_hsa047242.57571791
10Phototransduction_Homo sapiens_hsa047442.43084090
11Morphine addiction_Homo sapiens_hsa050322.37129524
12DNA replication_Homo sapiens_hsa030302.31543910
13* RNA degradation_Homo sapiens_hsa030182.31225493
14Circadian entrainment_Homo sapiens_hsa047132.30087889
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27189490
16Nucleotide excision repair_Homo sapiens_hsa034202.22092352
17GABAergic synapse_Homo sapiens_hsa047272.20723168
18RNA transport_Homo sapiens_hsa030132.20588366
19Base excision repair_Homo sapiens_hsa034102.20271943
20RNA polymerase_Homo sapiens_hsa030202.18431726
21Serotonergic synapse_Homo sapiens_hsa047262.08030226
22Amphetamine addiction_Homo sapiens_hsa050312.00149852
23Taste transduction_Homo sapiens_hsa047421.98074255
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96631456
25Long-term potentiation_Homo sapiens_hsa047201.92736923
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91437545
27One carbon pool by folate_Homo sapiens_hsa006701.90425134
28Cell cycle_Homo sapiens_hsa041101.88223540
29Spliceosome_Homo sapiens_hsa030401.75637297
30Olfactory transduction_Homo sapiens_hsa047401.74930501
31Renin secretion_Homo sapiens_hsa049241.64413771
32Salivary secretion_Homo sapiens_hsa049701.64273533
33Calcium signaling pathway_Homo sapiens_hsa040201.63334328
34Dopaminergic synapse_Homo sapiens_hsa047281.57283750
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55515362
36Ether lipid metabolism_Homo sapiens_hsa005651.55438096
37Propanoate metabolism_Homo sapiens_hsa006401.53717543
38Long-term depression_Homo sapiens_hsa047301.52633952
39Primary immunodeficiency_Homo sapiens_hsa053401.50664247
40Insulin secretion_Homo sapiens_hsa049111.48103971
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45140724
42Cocaine addiction_Homo sapiens_hsa050301.44890974
43Cholinergic synapse_Homo sapiens_hsa047251.34874571
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33912760
45p53 signaling pathway_Homo sapiens_hsa041151.33033953
46Autoimmune thyroid disease_Homo sapiens_hsa053201.32326899
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31671908
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28816777
49cAMP signaling pathway_Homo sapiens_hsa040241.22172204
50Protein export_Homo sapiens_hsa030601.21406500
51Antigen processing and presentation_Homo sapiens_hsa046121.21329357
52Collecting duct acid secretion_Homo sapiens_hsa049661.20018175
53mRNA surveillance pathway_Homo sapiens_hsa030151.17340965
54Systemic lupus erythematosus_Homo sapiens_hsa053221.15485984
55Axon guidance_Homo sapiens_hsa043601.14485649
56Gastric acid secretion_Homo sapiens_hsa049711.13921418
57Selenocompound metabolism_Homo sapiens_hsa004501.12120771
58Herpes simplex infection_Homo sapiens_hsa051681.11668456
59Oxytocin signaling pathway_Homo sapiens_hsa049211.11307747
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09931336
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09705374
62Synaptic vesicle cycle_Homo sapiens_hsa047211.08774780
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08682963
64Pyrimidine metabolism_Homo sapiens_hsa002401.07043745
65Sphingolipid metabolism_Homo sapiens_hsa006001.06633777
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.04337694
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03190496
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02840712
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02029573
70Vascular smooth muscle contraction_Homo sapiens_hsa042701.00500365
71Oocyte meiosis_Homo sapiens_hsa041140.99961753
72Purine metabolism_Homo sapiens_hsa002300.99252694
73Fatty acid elongation_Homo sapiens_hsa000620.98875393
74African trypanosomiasis_Homo sapiens_hsa051430.98034335
75Allograft rejection_Homo sapiens_hsa053300.97887010
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95156117
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93076221
78Hematopoietic cell lineage_Homo sapiens_hsa046400.92523872
79T cell receptor signaling pathway_Homo sapiens_hsa046600.92382091
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90721328
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87295868
82Pancreatic secretion_Homo sapiens_hsa049720.86544706
83B cell receptor signaling pathway_Homo sapiens_hsa046620.85753904
84Epstein-Barr virus infection_Homo sapiens_hsa051690.84870985
85Butanoate metabolism_Homo sapiens_hsa006500.84652654
86Rheumatoid arthritis_Homo sapiens_hsa053230.83198770
87GnRH signaling pathway_Homo sapiens_hsa049120.81602633
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81310475
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80711270
90MAPK signaling pathway_Homo sapiens_hsa040100.78595955
91Ras signaling pathway_Homo sapiens_hsa040140.78562685
92Caffeine metabolism_Homo sapiens_hsa002320.76503287
93Ribosome_Homo sapiens_hsa030100.76264982
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74106762
95Vibrio cholerae infection_Homo sapiens_hsa051100.73382783
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72919206
97Parkinsons disease_Homo sapiens_hsa050120.71224390
98Alzheimers disease_Homo sapiens_hsa050100.68490206
99Nitrogen metabolism_Homo sapiens_hsa009100.68167056
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67668119
101Circadian rhythm_Homo sapiens_hsa047100.67496025
102Peroxisome_Homo sapiens_hsa041460.66571238
103Type I diabetes mellitus_Homo sapiens_hsa049400.66491341
104Ovarian steroidogenesis_Homo sapiens_hsa049130.66093518
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.64525853
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64348162
107Regulation of autophagy_Homo sapiens_hsa041400.63501267
108Chemokine signaling pathway_Homo sapiens_hsa040620.63397455
109Graft-versus-host disease_Homo sapiens_hsa053320.61407249
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60567462
111Choline metabolism in cancer_Homo sapiens_hsa052310.60162548
112ErbB signaling pathway_Homo sapiens_hsa040120.60127660
113Viral carcinogenesis_Homo sapiens_hsa052030.59970448
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59556716
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59504360
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59339203
117Measles_Homo sapiens_hsa051620.59130553
118Type II diabetes mellitus_Homo sapiens_hsa049300.58938924
119Viral myocarditis_Homo sapiens_hsa054160.58764498
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56580801
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54156196
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54006427
123Oxidative phosphorylation_Homo sapiens_hsa001900.53647144
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.52511529
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.51150273
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50934651
127Platelet activation_Homo sapiens_hsa046110.50562325
128Wnt signaling pathway_Homo sapiens_hsa043100.50408482
129Inositol phosphate metabolism_Homo sapiens_hsa005620.50114894
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.49833309
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.49355730
132Linoleic acid metabolism_Homo sapiens_hsa005910.49186453
133Huntingtons disease_Homo sapiens_hsa050160.46713225
134Legionellosis_Homo sapiens_hsa051340.45530934
135Thyroid hormone synthesis_Homo sapiens_hsa049180.44193114
136Dorso-ventral axis formation_Homo sapiens_hsa043200.43218432
137Arachidonic acid metabolism_Homo sapiens_hsa005900.42891635
138Melanogenesis_Homo sapiens_hsa049160.42888202
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.42547442
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42016935
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41898811
142Steroid biosynthesis_Homo sapiens_hsa001000.41693977
143Asthma_Homo sapiens_hsa053100.41456737
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40730572
145Fanconi anemia pathway_Homo sapiens_hsa034600.39665163
146Rap1 signaling pathway_Homo sapiens_hsa040150.39653147
147Osteoclast differentiation_Homo sapiens_hsa043800.39456973
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38967533
149Cardiac muscle contraction_Homo sapiens_hsa042600.38751813
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.37811472
151Alcoholism_Homo sapiens_hsa050340.33461560
152Hepatitis B_Homo sapiens_hsa051610.32079380
153N-Glycan biosynthesis_Homo sapiens_hsa005100.31384296
154Influenza A_Homo sapiens_hsa051640.30209722
155Leishmaniasis_Homo sapiens_hsa051400.29588293
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27951682
157HTLV-I infection_Homo sapiens_hsa051660.26675021
158Metabolic pathways_Homo sapiens_hsa011000.24016268
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21783500
160Sulfur metabolism_Homo sapiens_hsa009200.19250184
161TGF-beta signaling pathway_Homo sapiens_hsa043500.15578982
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12335448
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12094667
164Tuberculosis_Homo sapiens_hsa051520.12076519
165Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11411103

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