ZCCHC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.11065626
2ribosomal small subunit assembly (GO:0000028)5.04377205
3ATP synthesis coupled proton transport (GO:0015986)4.54459958
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54459958
5ribosomal small subunit biogenesis (GO:0042274)4.47141032
6response to pheromone (GO:0019236)4.46265912
7mitochondrial respiratory chain complex assembly (GO:0033108)4.23326479
8viral transcription (GO:0019083)4.20615073
9maturation of SSU-rRNA (GO:0030490)4.15478770
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10322001
11translational termination (GO:0006415)4.08850778
12cotranslational protein targeting to membrane (GO:0006613)4.08756437
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08578568
14DNA deamination (GO:0045006)4.02523862
15protein targeting to ER (GO:0045047)4.00320578
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.99425610
17protein localization to endoplasmic reticulum (GO:0070972)3.78431365
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78086198
19respiratory electron transport chain (GO:0022904)3.71771881
20regulation of mitochondrial translation (GO:0070129)3.69699349
21electron transport chain (GO:0022900)3.67544916
22histone exchange (GO:0043486)3.63571848
23cytochrome complex assembly (GO:0017004)3.60091615
24proteasome assembly (GO:0043248)3.50203475
25DNA replication checkpoint (GO:0000076)3.50189226
26synapsis (GO:0007129)3.44133439
27polyketide metabolic process (GO:0030638)3.41677819
28doxorubicin metabolic process (GO:0044598)3.41677819
29daunorubicin metabolic process (GO:0044597)3.41677819
30translational elongation (GO:0006414)3.35036237
31DNA double-strand break processing (GO:0000729)3.30399806
327-methylguanosine RNA capping (GO:0009452)3.29113503
33RNA capping (GO:0036260)3.29113503
34water-soluble vitamin biosynthetic process (GO:0042364)3.27973673
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23933562
36regulation of mitotic spindle checkpoint (GO:1903504)3.23933562
37DNA replication-independent nucleosome organization (GO:0034724)3.19416265
38DNA replication-independent nucleosome assembly (GO:0006336)3.19416265
39viral life cycle (GO:0019058)3.19346013
40ribosomal large subunit biogenesis (GO:0042273)3.16963542
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.14175121
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13855619
43protein-cofactor linkage (GO:0018065)3.13167998
447-methylguanosine mRNA capping (GO:0006370)3.10173471
45signal peptide processing (GO:0006465)3.09053992
46replication fork processing (GO:0031297)3.07403036
47cellular protein complex disassembly (GO:0043624)3.06660498
48CENP-A containing nucleosome assembly (GO:0034080)3.04720664
49termination of RNA polymerase III transcription (GO:0006386)3.04324256
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.04324256
51translational initiation (GO:0006413)3.03206736
52organelle disassembly (GO:1903008)2.99115713
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95066916
54transcription elongation from RNA polymerase I promoter (GO:0006362)2.92248216
55telomere maintenance via semi-conservative replication (GO:0032201)2.91797177
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91097265
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91097265
58rRNA modification (GO:0000154)2.90187914
59protein K6-linked ubiquitination (GO:0085020)2.90164214
60translation (GO:0006412)2.88752178
61lymphoid progenitor cell differentiation (GO:0002320)2.88161789
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86771220
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85365100
64recombinational repair (GO:0000725)2.83137057
65ribonucleoprotein complex biogenesis (GO:0022613)2.83130728
66kinetochore organization (GO:0051383)2.81841434
67double-strand break repair via homologous recombination (GO:0000724)2.81449909
68protein deneddylation (GO:0000338)2.80290607
69tRNA processing (GO:0008033)2.79014310
70chromatin remodeling at centromere (GO:0031055)2.77595710
71termination of RNA polymerase I transcription (GO:0006363)2.76835348
72DNA damage response, detection of DNA damage (GO:0042769)2.76321681
73histone mRNA metabolic process (GO:0008334)2.75690762
74meiotic chromosome segregation (GO:0045132)2.75679849
75rRNA methylation (GO:0031167)2.74954951
76mannosylation (GO:0097502)2.74279942
77transcription-coupled nucleotide-excision repair (GO:0006283)2.73785264
78rRNA processing (GO:0006364)2.73651209
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73297956
80telomere maintenance via recombination (GO:0000722)2.73125266
81protein neddylation (GO:0045116)2.71527199
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70770682
83purine nucleobase biosynthetic process (GO:0009113)2.70689481
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70546284
85cullin deneddylation (GO:0010388)2.69841375
86kinetochore assembly (GO:0051382)2.69085243
87reciprocal meiotic recombination (GO:0007131)2.68617431
88reciprocal DNA recombination (GO:0035825)2.68617431
89negative regulation of ligase activity (GO:0051352)2.67425638
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67425638
91response to interferon-beta (GO:0035456)2.66997337
92centriole replication (GO:0007099)2.66761904
93pseudouridine synthesis (GO:0001522)2.64840692
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.63705906
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63074643
96protein localization to kinetochore (GO:0034501)2.62896983
97resolution of meiotic recombination intermediates (GO:0000712)2.62799354
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.62524177
99rRNA metabolic process (GO:0016072)2.58218331
100neutrophil activation involved in immune response (GO:0002283)2.57759528
101antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57259298
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57214741
103transcription from RNA polymerase I promoter (GO:0006360)2.56823770
104protein complex disassembly (GO:0043241)2.56319169
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.56177717
106spliceosomal complex assembly (GO:0000245)2.53234609
107mRNA catabolic process (GO:0006402)2.52745051
108cellular component biogenesis (GO:0044085)2.50183817
109mast cell activation (GO:0045576)2.49845880
110protein targeting to membrane (GO:0006612)2.49370713
111mitotic recombination (GO:0006312)2.49154052
112DNA ligation (GO:0006266)2.48295643
113peptidyl-histidine modification (GO:0018202)2.46991162
114regulation of T cell chemotaxis (GO:0010819)2.46487019
115positive regulation of T cell chemotaxis (GO:0010820)2.46487019
116DNA catabolic process, exonucleolytic (GO:0000738)2.45398966
117macromolecular complex disassembly (GO:0032984)2.45026029
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44390285
119RNA methylation (GO:0001510)2.43204428
120chaperone-mediated protein transport (GO:0072321)2.42708685
121cellular response to interferon-beta (GO:0035458)2.39594448
122tRNA methylation (GO:0030488)2.39213765
123mitochondrial respiratory chain complex I assembly (GO:0032981)2.38405649
124NADH dehydrogenase complex assembly (GO:0010257)2.38405649
125mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.38405649
126DNA strand elongation involved in DNA replication (GO:0006271)2.35934430
127protein complex biogenesis (GO:0070271)2.34030958
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.34027040
129spliceosomal snRNP assembly (GO:0000387)2.33721058
130deoxyribonucleotide catabolic process (GO:0009264)2.32485928
131RNA catabolic process (GO:0006401)2.32412309
132respiratory chain complex IV assembly (GO:0008535)2.32244695
133platelet dense granule organization (GO:0060155)2.31939835
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.30619402
135DNA strand elongation (GO:0022616)2.29935080
136transcription initiation from RNA polymerase I promoter (GO:0006361)2.29010790
137dendritic cell chemotaxis (GO:0002407)2.28490488
138transcription elongation from RNA polymerase II promoter (GO:0006368)2.28448893
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.28240151
140telomere maintenance via telomere lengthening (GO:0010833)2.27885505
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.27762451
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.27762451
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.27762451
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.26864859
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.26864859
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25572373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39967451
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04336699
3E2F7_22180533_ChIP-Seq_HELA_Human3.95182262
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.72347663
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.55613421
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.25115380
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24975493
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.15690437
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95820349
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94683670
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.71492142
12ELK1_19687146_ChIP-ChIP_HELA_Human2.71020678
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68028217
14* VDR_23849224_ChIP-Seq_CD4+_Human2.66886000
15ZNF274_21170338_ChIP-Seq_K562_Hela2.59990714
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58035895
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56633911
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.54576039
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54510999
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50816628
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46572745
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45441637
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39321187
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.35466985
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34376753
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31205195
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.29667927
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24528548
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24439487
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.23829196
31* SRF_21415370_ChIP-Seq_HL-1_Mouse2.17005428
32FOXP3_21729870_ChIP-Seq_TREG_Human2.15048054
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14622364
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11420552
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10709463
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.10151432
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08430786
38VDR_22108803_ChIP-Seq_LS180_Human2.07700951
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.89169158
40DCP1A_22483619_ChIP-Seq_HELA_Human1.85863551
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84453259
42XRN2_22483619_ChIP-Seq_HELA_Human1.76921647
43SPI1_23547873_ChIP-Seq_NB4_Human1.75528526
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71697663
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67813717
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66935606
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66924464
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65330314
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64618341
50TTF2_22483619_ChIP-Seq_HELA_Human1.64567420
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.64447579
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61432604
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56604099
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53326137
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50419978
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48007187
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43571823
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.42318954
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39927684
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37300280
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37217257
62P300_19829295_ChIP-Seq_ESCs_Human1.36880818
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36474163
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34310462
65* GABP_19822575_ChIP-Seq_HepG2_Human1.33096378
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31977805
67* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30619213
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30218304
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30088212
70TAF15_26573619_Chip-Seq_HEK293_Human1.26703425
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.24933196
72CIITA_25753668_ChIP-Seq_RAJI_Human1.24316503
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23997251
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23463782
75SCL_19346495_ChIP-Seq_HPC-7_Human1.22904049
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.22346634
77IRF1_19129219_ChIP-ChIP_H3396_Human1.22118016
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21339120
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21107559
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.17779803
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17475481
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17436581
83ER_23166858_ChIP-Seq_MCF-7_Human1.17229667
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17228082
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16289838
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.15461217
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14907506
88EWS_26573619_Chip-Seq_HEK293_Human1.13374203
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12812190
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12545393
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12304618
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12132984
93TP53_22573176_ChIP-Seq_HFKS_Human1.09076806
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08943640
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08876954
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.08098549
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08057371
98* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03358546
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02246865
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.01475401
101FUS_26573619_Chip-Seq_HEK293_Human1.00525275
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00215447
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99887888
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99821095
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.99821095
106IGF1R_20145208_ChIP-Seq_DFB_Human0.99075529
107AR_21909140_ChIP-Seq_LNCAP_Human0.98828472
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98391997
109MYC_18940864_ChIP-ChIP_HL60_Human0.98075818
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.96878212
111NANOG_19829295_ChIP-Seq_ESCs_Human0.96037702
112SOX2_19829295_ChIP-Seq_ESCs_Human0.96037702
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95967845
114KDM5A_27292631_Chip-Seq_BREAST_Human0.95681712
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95618051
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92818259
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91900104
118MYB_26560356_Chip-Seq_TH2_Human0.91368134
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.89868667
120AR_20517297_ChIP-Seq_VCAP_Human0.89003544
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88663586
122* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88383701
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88201628
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86614797
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86343669
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84994183
127CBP_20019798_ChIP-Seq_JUKART_Human0.84994183
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84260923
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84244088
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82783499
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81918537
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.81728503
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81675133
134TFEB_21752829_ChIP-Seq_HELA_Human0.81655218
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81536381
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80797893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.26682563
2MP0008877_abnormal_DNA_methylation2.83924939
3MP0001835_abnormal_antigen_presentation2.81754090
4MP0009785_altered_susceptibility_to2.75309583
5MP0006292_abnormal_olfactory_placode2.65539658
6MP0002148_abnormal_hypersensitivity_rea2.60941458
7MP0002396_abnormal_hematopoietic_system2.48982426
8MP0009697_abnormal_copulation2.36710298
9MP0005671_abnormal_response_to2.36687079
10MP0009379_abnormal_foot_pigmentation2.30003884
11MP0008058_abnormal_DNA_repair2.18630593
12MP0003195_calcinosis2.12417258
13MP0005000_abnormal_immune_tolerance2.10765674
14MP0010094_abnormal_chromosome_stability2.10481517
15MP0001986_abnormal_taste_sensitivity2.10192135
16MP0002938_white_spotting2.09377319
17MP0003890_abnormal_embryonic-extraembry2.06319567
18MP0002277_abnormal_respiratory_mucosa2.00182562
19MP0008007_abnormal_cellular_replicative1.98250051
20MP0001188_hyperpigmentation1.96135971
21MP0005174_abnormal_tail_pigmentation1.95430690
22MP0005025_abnormal_response_to1.89511373
23MP0001800_abnormal_humoral_immune1.89178905
24MP0006072_abnormal_retinal_apoptosis1.86949649
25MP0002452_abnormal_antigen_presenting1.86745861
26MP0002723_abnormal_immune_serum1.85729493
27MP0008057_abnormal_DNA_replication1.84602822
28MP0004957_abnormal_blastocyst_morpholog1.83726042
29MP0003763_abnormal_thymus_physiology1.83001014
30MP0005084_abnormal_gallbladder_morpholo1.82706168
31MP0003724_increased_susceptibility_to1.81216036
32MP0002420_abnormal_adaptive_immunity1.80145903
33MP0003436_decreased_susceptibility_to1.79673473
34MP0002419_abnormal_innate_immunity1.77782675
35MP0001819_abnormal_immune_cell1.77682157
36MP0002638_abnormal_pupillary_reflex1.77193891
37MP0003077_abnormal_cell_cycle1.75783504
38MP0002837_dystrophic_cardiac_calcinosis1.75483930
39MP0009333_abnormal_splenocyte_physiolog1.73431115
40MP0000015_abnormal_ear_pigmentation1.69920327
41MP0000372_irregular_coat_pigmentation1.65555378
42MP0005387_immune_system_phenotype1.64100699
43MP0001790_abnormal_immune_system1.64100699
44MP0003121_genomic_imprinting1.63523583
45MP0002095_abnormal_skin_pigmentation1.61080741
46MP0002398_abnormal_bone_marrow1.58858818
47MP0005171_absent_coat_pigmentation1.57973537
48MP0000569_abnormal_digit_pigmentation1.56850211
49MP0006036_abnormal_mitochondrial_physio1.56157903
50MP0008875_abnormal_xenobiotic_pharmacok1.54635619
51MP0006082_CNS_inflammation1.53675035
52MP0003136_yellow_coat_color1.52029536
53MP0002160_abnormal_reproductive_system1.51266783
54MP0001853_heart_inflammation1.50464533
55MP0002163_abnormal_gland_morphology1.50073912
56MP0000716_abnormal_immune_system1.46397080
57MP0005409_darkened_coat_color1.45354016
58MP0004808_abnormal_hematopoietic_stem1.44997155
59MP0000685_abnormal_immune_system1.44483868
60MP0003950_abnormal_plasma_membrane1.44318698
61MP0004133_heterotaxia1.43652780
62MP0008789_abnormal_olfactory_epithelium1.41399472
63MP0000490_abnormal_crypts_of1.40131432
64MP0002210_abnormal_sex_determination1.39858475
65MP0003937_abnormal_limbs/digits/tail_de1.39836206
66MP0004782_abnormal_surfactant_physiolog1.38357315
67MP0010030_abnormal_orbit_morphology1.37553938
68MP0005253_abnormal_eye_physiology1.36167944
69MP0006035_abnormal_mitochondrial_morpho1.34719918
70MP0003941_abnormal_skin_development1.34464245
71MP0001929_abnormal_gametogenesis1.32520814
72MP0000566_synostosis1.31789837
73MP0003806_abnormal_nucleotide_metabolis1.30850173
74MP0002006_tumorigenesis1.30406201
75MP0005551_abnormal_eye_electrophysiolog1.29955169
76MP0002132_abnormal_respiratory_system1.28995837
77MP0010155_abnormal_intestine_physiology1.28628776
78MP0003567_abnormal_fetal_cardiomyocyte1.27750187
79MP0005389_reproductive_system_phenotype1.27521723
80MP0002429_abnormal_blood_cell1.26199002
81MP0000631_abnormal_neuroendocrine_gland1.26067468
82MP0004147_increased_porphyrin_level1.25722184
83MP0002933_joint_inflammation1.25408207
84MP0003111_abnormal_nucleus_morphology1.25283344
85MP0001293_anophthalmia1.24881895
86MP0008995_early_reproductive_senescence1.24122443
87MP0008932_abnormal_embryonic_tissue1.23803841
88MP0000689_abnormal_spleen_morphology1.23554516
89MP0002405_respiratory_system_inflammati1.23334255
90MP0003786_premature_aging1.21341920
91MP0002722_abnormal_immune_system1.20561374
92MP0002234_abnormal_pharynx_morphology1.20306830
93MP0005075_abnormal_melanosome_morpholog1.18337237
94MP0001529_abnormal_vocalization1.18121681
95MP0005379_endocrine/exocrine_gland_phen1.16396492
96MP0000703_abnormal_thymus_morphology1.16266974
97MP0003186_abnormal_redox_activity1.16023084
98MP0002166_altered_tumor_susceptibility1.14946071
99MP0001764_abnormal_homeostasis1.13976631
100MP0003828_pulmonary_edema1.13369764
101MP0000647_abnormal_sebaceous_gland1.12270252
102MP0000653_abnormal_sex_gland1.11433131
103MP0001286_abnormal_eye_development1.09045890
104MP0001145_abnormal_male_reproductive1.08440631
105MP0001485_abnormal_pinna_reflex1.08273177
106MP0004381_abnormal_hair_follicle1.07172729
107MP0003698_abnormal_male_reproductive1.03578034
108MP0001845_abnormal_inflammatory_respons1.03413565
109MP0000681_abnormal_thyroid_gland1.02796589
110MP0005499_abnormal_olfactory_system1.00806282
111MP0005394_taste/olfaction_phenotype1.00806282
112MP0005410_abnormal_fertilization0.99503373
113MP0003283_abnormal_digestive_organ0.98520036
114MP0001119_abnormal_female_reproductive0.98497223
115MP0001186_pigmentation_phenotype0.98131097
116MP0001324_abnormal_eye_pigmentation0.97454618
117MP0004142_abnormal_muscle_tone0.96439290
118MP0003122_maternal_imprinting0.96001300
119MP0000427_abnormal_hair_cycle0.95167697
120MP0005391_vision/eye_phenotype0.94188532
121MP0005397_hematopoietic_system_phenotyp0.93869975
122MP0001545_abnormal_hematopoietic_system0.93869975
123MP0002282_abnormal_trachea_morphology0.91625336
124MP0002138_abnormal_hepatobiliary_system0.91235614
125MP0008872_abnormal_physiological_respon0.90648507
126MP0005332_abnormal_amino_acid0.90243984
127MP0002177_abnormal_outer_ear0.88977265
128MP0001533_abnormal_skeleton_physiology0.87878675
129MP0005085_abnormal_gallbladder_physiolo0.87688456
130MP0003718_maternal_effect0.85665012
131MP0003252_abnormal_bile_duct0.85656753
132MP0000313_abnormal_cell_death0.84559782
133MP0005365_abnormal_bile_salt0.83845077
134MP0000858_altered_metastatic_potential0.82369875
135MP0008469_abnormal_protein_level0.81838733
136MP0003866_abnormal_defecation0.81564596
137MP0002139_abnormal_hepatobiliary_system0.81213063
138MP0003011_delayed_dark_adaptation0.80772438
139MP0005464_abnormal_platelet_physiology0.80360804
140MP0001697_abnormal_embryo_size0.80358162
141MP0002019_abnormal_tumor_incidence0.79387707
142MP0008004_abnormal_stomach_pH0.78910374
143MP0001919_abnormal_reproductive_system0.78821004
144MP0000049_abnormal_middle_ear0.78091733
145MP0003943_abnormal_hepatobiliary_system0.77638435
146MP0002876_abnormal_thyroid_physiology0.77549343
147MP0000358_abnormal_cell_content/0.77453833
148MP0002009_preneoplasia0.76854508
149MP0005408_hypopigmentation0.75299071
150MP0003936_abnormal_reproductive_system0.74890751
151MP0003646_muscle_fatigue0.74690808
152MP0009764_decreased_sensitivity_to0.74196018
153MP0001542_abnormal_bone_strength0.73838070
154MP0002254_reproductive_system_inflammat0.73337939
155MP0000383_abnormal_hair_follicle0.73251500
156MP0002928_abnormal_bile_duct0.73171766
157MP0002102_abnormal_ear_morphology0.73119392
158MP0005390_skeleton_phenotype0.73014124
159MP0002233_abnormal_nose_morphology0.72964135
160MP0002075_abnormal_coat/hair_pigmentati0.71620086
161MP0003119_abnormal_digestive_system0.71242399
162MP0003787_abnormal_imprinting0.70172460
163MP0005195_abnormal_posterior_eye0.69801782
164MP0004019_abnormal_vitamin_homeostasis0.69463768
165MP0000465_gastrointestinal_hemorrhage0.67943425
166MP0005310_abnormal_salivary_gland0.66735965

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.16728163
2Abnormal number of erythroid precursors (HP:0012131)3.99581486
3Acute encephalopathy (HP:0006846)3.79632252
4Reticulocytopenia (HP:0001896)3.54888179
5Increased hepatocellular lipid droplets (HP:0006565)3.54757370
6Progressive macrocephaly (HP:0004481)3.45668613
7Type I transferrin isoform profile (HP:0003642)3.38744574
8Hypothermia (HP:0002045)3.22592580
9Renal Fanconi syndrome (HP:0001994)3.17072323
10Pancreatic fibrosis (HP:0100732)3.12963112
11Aplastic anemia (HP:0001915)3.07990332
12Exertional dyspnea (HP:0002875)3.02311264
13Recurrent abscess formation (HP:0002722)2.97019047
14Abnormality of the columella (HP:0009929)2.93347081
15Abnormality of midbrain morphology (HP:0002418)2.92534034
16Molar tooth sign on MRI (HP:0002419)2.92534034
17Lipid accumulation in hepatocytes (HP:0006561)2.89604587
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86080066
19Meckel diverticulum (HP:0002245)2.80525288
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.72685397
21Pallor (HP:0000980)2.71200319
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69705160
23Nephronophthisis (HP:0000090)2.68929465
24Abnormality of the ileum (HP:0001549)2.68926886
25Cerebral edema (HP:0002181)2.63298162
26Birth length less than 3rd percentile (HP:0003561)2.60325849
27Mitochondrial inheritance (HP:0001427)2.60033203
28Methylmalonic acidemia (HP:0002912)2.57322551
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52169876
30Abnormal protein N-linked glycosylation (HP:0012347)2.52169876
31Abnormal protein glycosylation (HP:0012346)2.52169876
32Abnormal glycosylation (HP:0012345)2.52169876
33Recurrent bacterial skin infections (HP:0005406)2.51132577
34Microvesicular hepatic steatosis (HP:0001414)2.49786909
35Abnormality of the renal cortex (HP:0011035)2.48492812
36Medial flaring of the eyebrow (HP:0010747)2.48266245
37Abnormality of the labia minora (HP:0012880)2.46781906
38Eosinophilia (HP:0001880)2.43989797
39Reduced antithrombin III activity (HP:0001976)2.43468455
40Macrocytic anemia (HP:0001972)2.43033121
41Granulocytopenia (HP:0001913)2.42804150
42Chronic otitis media (HP:0000389)2.39419885
433-Methylglutaconic aciduria (HP:0003535)2.39124734
44Abnormality of chromosome stability (HP:0003220)2.37839107
45Respiratory difficulties (HP:0002880)2.36394947
46Patchy hypopigmentation of hair (HP:0011365)2.35746505
47Absent thumb (HP:0009777)2.35027719
48Abnormality of renal resorption (HP:0011038)2.33974646
49Abnormality of eosinophils (HP:0001879)2.33827909
50IgM deficiency (HP:0002850)2.31025474
51Elevated erythrocyte sedimentation rate (HP:0003565)2.28242614
52Lactic acidosis (HP:0003128)2.27992114
53Abnormality of urine glucose concentration (HP:0011016)2.26401206
54Glycosuria (HP:0003076)2.26401206
55Abnormality of the renal medulla (HP:0100957)2.26287641
56B lymphocytopenia (HP:0010976)2.25633742
57Abnormality of B cell number (HP:0010975)2.25633742
58Colon cancer (HP:0003003)2.25351044
59True hermaphroditism (HP:0010459)2.24327451
60Optic disc pallor (HP:0000543)2.24139213
61Hyperalaninemia (HP:0003348)2.21651593
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21651593
63Abnormality of alanine metabolism (HP:0010916)2.21651593
64Parakeratosis (HP:0001036)2.21232237
65Optic nerve coloboma (HP:0000588)2.19727319
66Abnormal hair whorl (HP:0010721)2.19609288
67White forelock (HP:0002211)2.19335477
68Acute necrotizing encephalopathy (HP:0006965)2.18705904
69Hepatocellular necrosis (HP:0001404)2.16434259
70Septo-optic dysplasia (HP:0100842)2.15970640
71Thrombocytosis (HP:0001894)2.15896024
72Increased CSF lactate (HP:0002490)2.15011182
73Congenital stationary night blindness (HP:0007642)2.14862743
74Lymphoma (HP:0002665)2.13149086
75Supernumerary spleens (HP:0009799)2.12621264
76Abnormality of T cell number (HP:0011839)2.12493321
77Recurrent viral infections (HP:0004429)2.11412308
78Recurrent pneumonia (HP:0006532)2.10177837
79Respiratory failure (HP:0002878)2.10083940
80T lymphocytopenia (HP:0005403)2.09399686
81Lymphopenia (HP:0001888)2.09159615
82Poor head control (HP:0002421)2.09146888
83Chromsome breakage (HP:0040012)2.08805924
84Triphalangeal thumb (HP:0001199)2.08786593
85Bile duct proliferation (HP:0001408)2.08208527
86Abnormal biliary tract physiology (HP:0012439)2.08208527
87Methylmalonic aciduria (HP:0012120)2.07129171
88Volvulus (HP:0002580)2.06822748
89Pendular nystagmus (HP:0012043)2.06529603
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.06128352
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.04794365
92Abnormality of methionine metabolism (HP:0010901)2.04354521
93Hyperglycinemia (HP:0002154)2.02757382
94IgG deficiency (HP:0004315)2.02608198
95Cleft eyelid (HP:0000625)2.02581419
96Duodenal stenosis (HP:0100867)2.01531696
97Small intestinal stenosis (HP:0012848)2.01531696
98Sclerocornea (HP:0000647)1.99420927
99Abnormality of the pons (HP:0007361)1.99039699
100Congenital primary aphakia (HP:0007707)1.98851657
101Severe combined immunodeficiency (HP:0004430)1.98819084
102Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96691435
103Abnormality of the axillary hair (HP:0100134)1.94968220
104Abnormality of secondary sexual hair (HP:0009888)1.94968220
105Exercise intolerance (HP:0003546)1.94693436
106Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93714480
107Sloping forehead (HP:0000340)1.93459185
108Hepatic necrosis (HP:0002605)1.92591602
109Thyroiditis (HP:0100646)1.91889668
110Myelodysplasia (HP:0002863)1.91128831
111Panhypogammaglobulinemia (HP:0003139)1.90896340
112Anencephaly (HP:0002323)1.90864786
113Agammaglobulinemia (HP:0004432)1.89964036
114Acute myeloid leukemia (HP:0004808)1.89700134
115Preaxial hand polydactyly (HP:0001177)1.89558322
116Recurrent skin infections (HP:0001581)1.88758303
117Leukodystrophy (HP:0002415)1.88631037
118Abnormality of the duodenum (HP:0002246)1.88260441
119Lethargy (HP:0001254)1.86784234
120Abnormality of the prostate (HP:0008775)1.86450680
121Premature graying of hair (HP:0002216)1.85849431
122Mediastinal lymphadenopathy (HP:0100721)1.85750744
123Abnormal lung lobation (HP:0002101)1.85658585
124Abnormality of the preputium (HP:0100587)1.85643782
125Abnormality of T cells (HP:0002843)1.85219588
126Chronic diarrhea (HP:0002028)1.85112175
127Small hand (HP:0200055)1.84402698
128Oligodactyly (hands) (HP:0001180)1.84214199
129Hypoplasia of the pons (HP:0012110)1.84039500
130Leukocytosis (HP:0001974)1.83598498
131Pancreatic cysts (HP:0001737)1.83544070
132Obstructive lung disease (HP:0006536)1.82817259
133Chronic obstructive pulmonary disease (HP:0006510)1.82817259
134Absent septum pellucidum (HP:0001331)1.81486686
135Nephrogenic diabetes insipidus (HP:0009806)1.81471454
136Myositis (HP:0100614)1.80673516
137Abnormality of macrophages (HP:0004311)1.80430120
138Congenital sensorineural hearing impairment (HP:0008527)1.80109000
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.79774728
140Abnormality of serum amino acid levels (HP:0003112)1.79179181
141Clubbing of toes (HP:0100760)1.78584092
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78552070
143Congenital, generalized hypertrichosis (HP:0004540)1.78484494
144Recurrent fungal infections (HP:0002841)1.78313091
145Increased intramyocellular lipid droplets (HP:0012240)1.77873148
146Gait imbalance (HP:0002141)1.77731728
147Retrobulbar optic neuritis (HP:0100654)1.76691389
148Optic neuritis (HP:0100653)1.76691389
149Increased muscle lipid content (HP:0009058)1.75729772
150Intestinal atresia (HP:0011100)1.74651873
151Dry hair (HP:0011359)1.74348942
152Abnormal mitochondria in muscle tissue (HP:0008316)1.74030112
153Severe visual impairment (HP:0001141)1.73769443
154Autoimmune hemolytic anemia (HP:0001890)1.73632840
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71799414
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71799414
157Chronic mucocutaneous candidiasis (HP:0002728)1.71186047
158Recurrent cutaneous fungal infections (HP:0011370)1.71186047
159Renal cortical cysts (HP:0000803)1.70571767
160Type 2 muscle fiber atrophy (HP:0003554)1.69988682
161Muscle fiber atrophy (HP:0100295)1.68412538
162Increased serum lactate (HP:0002151)1.68234802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.00899797
2STK162.97346076
3NME22.77715025
4FRK2.69078743
5BRSK22.62966672
6VRK12.55212303
7WNK32.48633542
8IRAK32.46116225
9IRAK42.37487151
10TEC2.26992181
11TXK2.23842344
12BUB12.01356347
13TTK1.99997177
14TNIK1.99754190
15MAP3K141.98837199
16WEE11.97996711
17NEK11.91605002
18MAP4K21.91344234
19SRPK11.87289091
20NME11.87243218
21KIT1.84480969
22RPS6KA41.82938749
23SIK31.76520467
24MST41.75415004
25TLK11.75181242
26MKNK11.72431823
27CDK81.68895015
28ZAK1.68300470
29BMPR1B1.65598242
30MAP4K11.53487628
31EIF2AK31.52690939
32PLK41.52092159
33PIM21.50093459
34PASK1.46675435
35NUAK11.44762366
36CCNB11.43795859
37YES11.43418210
38MKNK21.42792855
39EIF2AK11.41000426
40EIF2AK21.40941992
41FLT31.38823123
42NEK21.38682411
43TRIM281.33814797
44PDK21.28240114
45PBK1.27606180
46ACVR1B1.26233641
47IKBKB1.21650066
48GRK11.20712383
49ADRBK21.19511745
50BRD41.14932163
51BTK1.12619874
52MAP3K121.12099678
53INSRR1.06902157
54MAP3K41.05516107
55NEK91.04765368
56TGFBR11.02376371
57CDK31.01149909
58BCKDK1.01134989
59STK31.01049773
60PLK20.98837080
61ERBB30.98446147
62NLK0.97262775
63IKBKE0.96719457
64BRSK10.95847831
65MARK30.95314352
66IRAK10.95188278
67ITK0.95107998
68NEK60.93973359
69GRK70.93053793
70TAF10.92874115
71PNCK0.92792842
72WNK40.92335883
73FGFR20.91296726
74LYN0.90526775
75STK100.88822654
76MUSK0.88388857
77BLK0.88325994
78JAK30.88026754
79BMPR20.84800563
80CDK70.84745765
81OXSR10.82918546
82CSF1R0.81999570
83PLK30.81779149
84RPS6KA50.80839624
85PIK3CG0.80231535
86CASK0.78499644
87ATR0.78463575
88LCK0.76604985
89SYK0.71120026
90AKT30.69133908
91STK38L0.68901815
92MAP2K70.68732799
93EPHA30.68500350
94CHUK0.68262627
95ATM0.65680897
96TSSK60.64277779
97AURKB0.63668058
98FGFR10.62966363
99PIM10.62811461
100TAOK30.62233461
101STK390.61578672
102CHEK20.60072709
103ZAP700.59691510
104TYK20.59317382
105MAP3K60.57841762
106PIK3CA0.57763176
107PINK10.57563587
108PRKCG0.53182278
109MAPKAPK50.52489076
110ADRBK10.51775563
111TGFBR20.51372895
112CSNK1G10.50661726
113CDC70.50235335
114PRKCE0.49912053
115CHEK10.48972756
116CSNK2A10.47783578
117DYRK30.47765479
118CLK10.47257231
119PLK10.46398522
120MAPK130.46199242
121STK40.43592024
122DYRK20.42833663
123MAP3K110.42575011
124TBK10.39078500
125CSNK1E0.38661262
126PRKCQ0.38649533
127RPS6KB20.38476585
128ERBB40.37886645
129MYLK0.37866971
130CSNK2A20.35576481
131CSNK1A10.35100671
132MAP2K30.35075696
133PRKACB0.35039176
134BCR0.34237775
135MAPKAPK20.33737728
136PRKCI0.33552696
137MAP3K130.33414851
138PAK30.31974362
139STK240.31753399
140CDK10.28272994
141MAP2K60.26819534
142PRKDC0.25510751
143AURKA0.25424610
144CDK20.23453180

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.92499760
2Protein export_Homo sapiens_hsa030603.38999193
3DNA replication_Homo sapiens_hsa030302.87602529
4RNA polymerase_Homo sapiens_hsa030202.79800757
5Proteasome_Homo sapiens_hsa030502.69922928
6Mismatch repair_Homo sapiens_hsa034302.61543563
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47230406
8Homologous recombination_Homo sapiens_hsa034402.47230343
9Base excision repair_Homo sapiens_hsa034102.24966490
10Spliceosome_Homo sapiens_hsa030402.22377232
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20391449
12Nucleotide excision repair_Homo sapiens_hsa034202.10542080
13Basal transcription factors_Homo sapiens_hsa030222.04441105
14Non-homologous end-joining_Homo sapiens_hsa034501.89061388
15Pyrimidine metabolism_Homo sapiens_hsa002401.85260291
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84844166
17Selenocompound metabolism_Homo sapiens_hsa004501.78002694
18Primary immunodeficiency_Homo sapiens_hsa053401.74123664
19Allograft rejection_Homo sapiens_hsa053301.73986921
20Fanconi anemia pathway_Homo sapiens_hsa034601.70822625
21Graft-versus-host disease_Homo sapiens_hsa053321.64023130
22Propanoate metabolism_Homo sapiens_hsa006401.63373804
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.61987974
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.55260421
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53261485
26Hematopoietic cell lineage_Homo sapiens_hsa046401.44754837
27Oxidative phosphorylation_Homo sapiens_hsa001901.43734454
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40768067
29RNA degradation_Homo sapiens_hsa030181.39309429
30RNA transport_Homo sapiens_hsa030131.31470441
31Herpes simplex infection_Homo sapiens_hsa051681.28944709
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28907569
33Butanoate metabolism_Homo sapiens_hsa006501.28636577
34Cell cycle_Homo sapiens_hsa041101.27871365
35Measles_Homo sapiens_hsa051621.24767998
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.24331611
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23031537
38Leishmaniasis_Homo sapiens_hsa051401.18706786
39Parkinsons disease_Homo sapiens_hsa050121.18208400
40Autoimmune thyroid disease_Homo sapiens_hsa053201.17534407
41Asthma_Homo sapiens_hsa053101.17381629
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16397832
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16097032
44Cardiac muscle contraction_Homo sapiens_hsa042601.10683661
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09918725
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09691575
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07867870
48Legionellosis_Homo sapiens_hsa051341.05101711
49Phototransduction_Homo sapiens_hsa047441.04497417
50Antigen processing and presentation_Homo sapiens_hsa046121.03685211
51Huntingtons disease_Homo sapiens_hsa050161.01261638
52Epstein-Barr virus infection_Homo sapiens_hsa051691.01209852
53Purine metabolism_Homo sapiens_hsa002301.00432276
54Type I diabetes mellitus_Homo sapiens_hsa049400.99189125
55Nitrogen metabolism_Homo sapiens_hsa009100.98899019
56Caffeine metabolism_Homo sapiens_hsa002320.98721652
57Peroxisome_Homo sapiens_hsa041460.97666508
58Pyruvate metabolism_Homo sapiens_hsa006200.97488815
59p53 signaling pathway_Homo sapiens_hsa041150.97150129
60Tryptophan metabolism_Homo sapiens_hsa003800.96469078
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95984738
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95449634
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94526360
64Rheumatoid arthritis_Homo sapiens_hsa053230.93145304
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92182425
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91833468
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89161325
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.88590750
69Arachidonic acid metabolism_Homo sapiens_hsa005900.87449234
70Pertussis_Homo sapiens_hsa051330.83758674
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83667903
72Malaria_Homo sapiens_hsa051440.83427472
73Glutathione metabolism_Homo sapiens_hsa004800.83217012
74Metabolic pathways_Homo sapiens_hsa011000.81124519
75Folate biosynthesis_Homo sapiens_hsa007900.80682744
76Sulfur metabolism_Homo sapiens_hsa009200.80486538
77Retinol metabolism_Homo sapiens_hsa008300.79400532
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78625615
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78610284
80Steroid biosynthesis_Homo sapiens_hsa001000.78262902
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78197366
82One carbon pool by folate_Homo sapiens_hsa006700.77482887
83Alzheimers disease_Homo sapiens_hsa050100.77331063
84Chemical carcinogenesis_Homo sapiens_hsa052040.76005320
85Fatty acid elongation_Homo sapiens_hsa000620.72978850
86Influenza A_Homo sapiens_hsa051640.71501323
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70360107
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.70337596
89N-Glycan biosynthesis_Homo sapiens_hsa005100.70070661
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64980359
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64360910
92Fatty acid degradation_Homo sapiens_hsa000710.63913408
93Ether lipid metabolism_Homo sapiens_hsa005650.61699244
94Phagosome_Homo sapiens_hsa041450.60715831
95Hepatitis B_Homo sapiens_hsa051610.60589949
96Apoptosis_Homo sapiens_hsa042100.59156625
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.58559434
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57999308
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57653062
100Systemic lupus erythematosus_Homo sapiens_hsa053220.57601866
101Osteoclast differentiation_Homo sapiens_hsa043800.57433519
102Sphingolipid metabolism_Homo sapiens_hsa006000.57254995
103Tuberculosis_Homo sapiens_hsa051520.57031970
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57011003
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54904217
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54570121
107B cell receptor signaling pathway_Homo sapiens_hsa046620.54226346
108beta-Alanine metabolism_Homo sapiens_hsa004100.54030433
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.53985516
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52061565
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.51750218
112HTLV-I infection_Homo sapiens_hsa051660.50763725
113TNF signaling pathway_Homo sapiens_hsa046680.49396005
114T cell receptor signaling pathway_Homo sapiens_hsa046600.49255997
115Vitamin digestion and absorption_Homo sapiens_hsa049770.46263372
116Regulation of autophagy_Homo sapiens_hsa041400.45016559
117Shigellosis_Homo sapiens_hsa051310.44410940
118Basal cell carcinoma_Homo sapiens_hsa052170.44376261
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44049995
120mRNA surveillance pathway_Homo sapiens_hsa030150.43871388
121Toxoplasmosis_Homo sapiens_hsa051450.43622120
122Oocyte meiosis_Homo sapiens_hsa041140.43602138
123African trypanosomiasis_Homo sapiens_hsa051430.43218761
124Viral carcinogenesis_Homo sapiens_hsa052030.42034370
125Sulfur relay system_Homo sapiens_hsa041220.41516322
126Other glycan degradation_Homo sapiens_hsa005110.40633783
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40586016
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40282325
129Hedgehog signaling pathway_Homo sapiens_hsa043400.39487100
130Fat digestion and absorption_Homo sapiens_hsa049750.38963544
131Viral myocarditis_Homo sapiens_hsa054160.36741344
132Salmonella infection_Homo sapiens_hsa051320.36737169
133Linoleic acid metabolism_Homo sapiens_hsa005910.35267842
134Acute myeloid leukemia_Homo sapiens_hsa052210.34464581
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34274997
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34082641
137Tyrosine metabolism_Homo sapiens_hsa003500.33575325
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31958359
139Fatty acid metabolism_Homo sapiens_hsa012120.30757041
140Carbon metabolism_Homo sapiens_hsa012000.30211855
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29310142
142Hepatitis C_Homo sapiens_hsa051600.26510563
143Mineral absorption_Homo sapiens_hsa049780.25651508
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25214102
145TGF-beta signaling pathway_Homo sapiens_hsa043500.24097135
146Prostate cancer_Homo sapiens_hsa052150.23823936
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23539678
148Vitamin B6 metabolism_Homo sapiens_hsa007500.22838441
149Arginine and proline metabolism_Homo sapiens_hsa003300.22331513
150Olfactory transduction_Homo sapiens_hsa047400.21769539
151Glycerolipid metabolism_Homo sapiens_hsa005610.18161551
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18075554
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17585950

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