ZCRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.84269573
2ATP synthesis coupled proton transport (GO:0015986)6.84269573
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.14387008
4ribosomal large subunit biogenesis (GO:0042273)5.45320046
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.25158173
6proteasome assembly (GO:0043248)5.22481493
7ribosomal small subunit biogenesis (GO:0042274)4.94145301
8respiratory electron transport chain (GO:0022904)4.91712487
9viral transcription (GO:0019083)4.85726020
10electron transport chain (GO:0022900)4.79391289
11translational termination (GO:0006415)4.73583019
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51852452
13cotranslational protein targeting to membrane (GO:0006613)4.51357449
14protein targeting to ER (GO:0045047)4.46567036
15regulation of mitochondrial translation (GO:0070129)4.37827707
16chaperone-mediated protein transport (GO:0072321)4.33325618
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.29797477
18CENP-A containing nucleosome assembly (GO:0034080)4.27098884
19protein complex biogenesis (GO:0070271)4.26898810
20chromatin remodeling at centromere (GO:0031055)4.25931934
21protein localization to endoplasmic reticulum (GO:0070972)4.25195709
22ribosomal small subunit assembly (GO:0000028)4.17078699
23GTP biosynthetic process (GO:0006183)3.97575039
24cytochrome complex assembly (GO:0017004)3.96244716
25peptidyl-histidine modification (GO:0018202)3.88550418
26translational elongation (GO:0006414)3.84828912
27mitochondrial respiratory chain complex assembly (GO:0033108)3.83478722
28cellular protein complex disassembly (GO:0043624)3.82546189
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.78075154
30termination of RNA polymerase III transcription (GO:0006386)3.78075154
31translation (GO:0006412)3.77645545
32maturation of SSU-rRNA (GO:0030490)3.74869670
33respiratory chain complex IV assembly (GO:0008535)3.66834371
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66155229
35DNA deamination (GO:0045006)3.62670782
36translational initiation (GO:0006413)3.54517124
37viral life cycle (GO:0019058)3.52758738
38regulation of oxidative phosphorylation (GO:0002082)3.50292386
39histone exchange (GO:0043486)3.46016492
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41925253
41protein neddylation (GO:0045116)3.38519863
42regulation of cellular amino acid metabolic process (GO:0006521)3.37650148
43positive regulation of mitochondrial fission (GO:0090141)3.36899114
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32148521
45negative regulation of ligase activity (GO:0051352)3.32148521
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30913563
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29200854
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29200854
49guanosine-containing compound biosynthetic process (GO:1901070)3.28061603
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27429917
51kinetochore assembly (GO:0051382)3.26725718
52oxidative phosphorylation (GO:0006119)3.26043809
53kinetochore organization (GO:0051383)3.25036134
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23214368
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.23214368
56NADH dehydrogenase complex assembly (GO:0010257)3.23214368
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22423950
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21261608
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.20545901
60respiratory burst (GO:0045730)3.17689928
61cullin deneddylation (GO:0010388)3.17023597
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16911736
63protein complex disassembly (GO:0043241)3.15759561
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12361857
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12122154
667-methylguanosine mRNA capping (GO:0006370)3.11427893
67spliceosomal snRNP assembly (GO:0000387)3.10222681
68negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.09048762
69UTP biosynthetic process (GO:0006228)3.08609693
70purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08217665
71macromolecular complex disassembly (GO:0032984)3.08100769
727-methylguanosine RNA capping (GO:0009452)3.06682217
73RNA capping (GO:0036260)3.06682217
74inner mitochondrial membrane organization (GO:0007007)3.03351767
75DNA replication-independent nucleosome organization (GO:0034724)3.02627894
76DNA replication-independent nucleosome assembly (GO:0006336)3.02627894
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02313064
78hydrogen ion transmembrane transport (GO:1902600)3.02099925
79protein targeting to membrane (GO:0006612)3.00439358
80intracellular protein transmembrane import (GO:0044743)3.00277425
81ATP biosynthetic process (GO:0006754)2.99457771
82cellular component biogenesis (GO:0044085)2.97390855
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95855544
84protein deneddylation (GO:0000338)2.91452753
85ribonucleoprotein complex biogenesis (GO:0022613)2.87952196
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86889697
87rRNA modification (GO:0000154)2.86769231
88establishment of integrated proviral latency (GO:0075713)2.86628452
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85308884
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82208071
91histone H2A acetylation (GO:0043968)2.82031594
92pyrimidine nucleotide catabolic process (GO:0006244)2.80948541
93protein targeting to mitochondrion (GO:0006626)2.79897278
94positive regulation of ligase activity (GO:0051351)2.79490399
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79390606
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79390606
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79390606
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78679197
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78679197
100pseudouridine synthesis (GO:0001522)2.77698851
101DNA damage response, detection of DNA damage (GO:0042769)2.75796244
102DNA replication checkpoint (GO:0000076)2.75027950
103organelle disassembly (GO:1903008)2.74886559
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.72459456
105establishment of protein localization to mitochondrion (GO:0072655)2.71467720
106signal transduction involved in DNA damage checkpoint (GO:0072422)2.71348106
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71348106
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.70426555
109dopamine transport (GO:0015872)2.69853929
110mitochondrial transport (GO:0006839)2.69270636
111regulation of cellular amine metabolic process (GO:0033238)2.68122208
112sarcoplasmic reticulum calcium ion transport (GO:0070296)2.68059181
113ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67459229
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67445264
115DNA ligation (GO:0006266)2.67046272
116positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.66305254
117protein localization to mitochondrion (GO:0070585)2.65155929
118water-soluble vitamin biosynthetic process (GO:0042364)2.64542216
119deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63886506
120histone mRNA metabolic process (GO:0008334)2.63469629
121proton transport (GO:0015992)2.63192761
122rRNA metabolic process (GO:0016072)2.62870972
123regulation of cilium movement (GO:0003352)2.62591193
124rRNA processing (GO:0006364)2.60215128
125protein-cofactor linkage (GO:0018065)2.57912929
126deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.55437396
127hydrogen transport (GO:0006818)2.55103839
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53657256
129nucleoside diphosphate phosphorylation (GO:0006165)2.52465994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.97765524
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22866874
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86618511
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65916754
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.53203632
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44641857
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.29433174
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.25294062
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16578220
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13809239
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78975744
12EZH2_22144423_ChIP-Seq_EOC_Human2.77828451
13E2F7_22180533_ChIP-Seq_HELA_Human2.52260719
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.41769036
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40119725
16DCP1A_22483619_ChIP-Seq_HELA_Human2.35072902
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23226997
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15217127
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13134216
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06165245
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01760847
22ZNF274_21170338_ChIP-Seq_K562_Hela1.97634564
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96159490
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93251737
25VDR_23849224_ChIP-Seq_CD4+_Human1.92110938
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87732571
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80139094
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71743445
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70834772
30ELK1_22589737_ChIP-Seq_MCF10A_Human1.64512084
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.61513960
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.59269908
33TTF2_22483619_ChIP-Seq_HELA_Human1.58448327
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56982984
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56350337
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.55371285
37FUS_26573619_Chip-Seq_HEK293_Human1.54161587
38ELK1_19687146_ChIP-ChIP_HELA_Human1.53402270
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50518142
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48077752
41XRN2_22483619_ChIP-Seq_HELA_Human1.47698091
42FOXP3_21729870_ChIP-Seq_TREG_Human1.47196471
43* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44622861
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41353633
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41113024
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39574049
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.38987434
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38616950
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38110404
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.36071704
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.35760960
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34998262
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31623394
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29865202
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28701578
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28101025
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27561098
58VDR_22108803_ChIP-Seq_LS180_Human1.26485530
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25820504
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25082427
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.23527766
62IRF1_19129219_ChIP-ChIP_H3396_Human1.22782432
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21797323
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21625483
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.21201906
66MYC_18940864_ChIP-ChIP_HL60_Human1.19621430
67RNF2_27304074_Chip-Seq_NSC_Mouse1.18633983
68GABP_19822575_ChIP-Seq_HepG2_Human1.17392571
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16035878
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14535304
71EWS_26573619_Chip-Seq_HEK293_Human1.12956898
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12866984
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.12760750
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12265254
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10839712
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09134859
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08857499
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.07031247
79IGF1R_20145208_ChIP-Seq_DFB_Human1.05382209
80TP53_22573176_ChIP-Seq_HFKS_Human1.05116421
81* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05027755
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.04866575
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04798595
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.04712469
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04491731
86GBX2_23144817_ChIP-Seq_PC3_Human1.04046053
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.02961123
88AR_21909140_ChIP-Seq_LNCAP_Human1.02687663
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02540289
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01938694
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01562514
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01069646
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00946006
94P53_22387025_ChIP-Seq_ESCs_Mouse1.00552361
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00549875
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99911492
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.99855433
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99730107
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99097523
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98630348
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97227891
102SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96418476
103HTT_18923047_ChIP-ChIP_STHdh_Human0.95018418
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.94920258
105* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94891617
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94419349
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.94353070
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.94193168
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.93980315
110P300_18555785_Chip-Seq_ESCs_Mouse0.93191072
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92833355
112TAF15_26573619_Chip-Seq_HEK293_Human0.91423690
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91416229
114RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91360738
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91360738
116ZFX_18555785_Chip-Seq_ESCs_Mouse0.91043360
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90945737
118P300_19829295_ChIP-Seq_ESCs_Human0.90568403
119SOX2_18555785_Chip-Seq_ESCs_Mouse0.90521302
120RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90334313
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89705684
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89550173
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89439075
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89360367
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89259411
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89003279
127SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88896442
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88852680
129KDM5A_27292631_Chip-Seq_BREAST_Human0.88418836
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88206347
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.88200685
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86396132
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86283413
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83939179
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80122292
136FOXA1_25329375_ChIP-Seq_VCAP_Human0.80031233
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80031233
138SOX2_19829295_ChIP-Seq_ESCs_Human0.77889748
139NANOG_19829295_ChIP-Seq_ESCs_Human0.77889748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.23632783
2MP0003880_abnormal_central_pattern3.41522426
3MP0009379_abnormal_foot_pigmentation2.99096116
4MP0008058_abnormal_DNA_repair2.91274820
5MP0002638_abnormal_pupillary_reflex2.74535214
6MP0002102_abnormal_ear_morphology2.59862169
7MP0002163_abnormal_gland_morphology2.48395294
8MP0005409_darkened_coat_color2.47680381
9MP0001905_abnormal_dopamine_level2.38779161
10MP0010030_abnormal_orbit_morphology2.36797955
11MP0010094_abnormal_chromosome_stability2.34298054
12MP0004145_abnormal_muscle_electrophysio2.24036404
13MP0005379_endocrine/exocrine_gland_phen2.23146744
14MP0003186_abnormal_redox_activity2.17663374
15MP0006292_abnormal_olfactory_placode2.14207391
16MP0002837_dystrophic_cardiac_calcinosis2.14112156
17MP0001529_abnormal_vocalization2.09298215
18MP0006072_abnormal_retinal_apoptosis2.00992647
19MP0006276_abnormal_autonomic_nervous1.97622984
20MP0002653_abnormal_ependyma_morphology1.94323631
21MP0002751_abnormal_autonomic_nervous1.91690157
22MP0001984_abnormal_olfaction1.83670517
23MP0002160_abnormal_reproductive_system1.81329253
24MP0004957_abnormal_blastocyst_morpholog1.81035475
25MP0005394_taste/olfaction_phenotype1.80033666
26MP0005499_abnormal_olfactory_system1.80033666
27MP0003938_abnormal_ear_development1.72761590
28MP0005645_abnormal_hypothalamus_physiol1.71188947
29MP0000049_abnormal_middle_ear1.68170177
30MP0003806_abnormal_nucleotide_metabolis1.65038039
31MP0005084_abnormal_gallbladder_morpholo1.64691754
32MP0008877_abnormal_DNA_methylation1.64375034
33MP0001293_anophthalmia1.63953039
34MP0000749_muscle_degeneration1.59872974
35MP0005423_abnormal_somatic_nervous1.57600497
36MP0010386_abnormal_urinary_bladder1.56799544
37MP0003077_abnormal_cell_cycle1.53139381
38MP0003111_abnormal_nucleus_morphology1.53060282
39MP0003136_yellow_coat_color1.50662478
40MP0000372_irregular_coat_pigmentation1.48946323
41MP0002272_abnormal_nervous_system1.47791712
42MP0001986_abnormal_taste_sensitivity1.47626705
43MP0002138_abnormal_hepatobiliary_system1.45944107
44MP0006036_abnormal_mitochondrial_physio1.43995574
45MP0003121_genomic_imprinting1.43765083
46MP0004742_abnormal_vestibular_system1.43458187
47MP0008932_abnormal_embryonic_tissue1.40831933
48MP0002735_abnormal_chemical_nociception1.40739880
49MP0002234_abnormal_pharynx_morphology1.40182221
50MP0004142_abnormal_muscle_tone1.39915791
51MP0003315_abnormal_perineum_morphology1.39101380
52MP0002210_abnormal_sex_determination1.36668537
53MP0001970_abnormal_pain_threshold1.31655148
54MP0003693_abnormal_embryo_hatching1.30604320
55MP0002734_abnormal_mechanical_nocicepti1.29883667
56MP0005389_reproductive_system_phenotype1.29532778
57MP0009046_muscle_twitch1.28619788
58MP0002184_abnormal_innervation1.28339934
59MP0000015_abnormal_ear_pigmentation1.27611766
60MP0008995_early_reproductive_senescence1.27194096
61MP0003718_maternal_effect1.25716834
62MP0001346_abnormal_lacrimal_gland1.24171228
63MP0004859_abnormal_synaptic_plasticity1.23288213
64MP0002876_abnormal_thyroid_physiology1.22969974
65MP0008007_abnormal_cellular_replicative1.22281882
66MP0001968_abnormal_touch/_nociception1.19866998
67MP0002736_abnormal_nociception_after1.18001399
68MP0002733_abnormal_thermal_nociception1.17799836
69MP0000566_synostosis1.17325682
70MP0003786_premature_aging1.16793820
71MP0000026_abnormal_inner_ear1.15851434
72MP0001929_abnormal_gametogenesis1.14791500
73MP0000678_abnormal_parathyroid_gland1.14506641
74MP0003635_abnormal_synaptic_transmissio1.13882684
75MP0002106_abnormal_muscle_physiology1.10746159
76MP0001145_abnormal_male_reproductive1.10629201
77MP0002233_abnormal_nose_morphology1.10264709
78MP0003787_abnormal_imprinting1.10127435
79MP0000653_abnormal_sex_gland1.09955231
80MP0001440_abnormal_grooming_behavior1.09947991
81MP0009745_abnormal_behavioral_response1.09791160
82MP0000750_abnormal_muscle_regeneration1.07875179
83MP0003646_muscle_fatigue1.06598599
84MP0002177_abnormal_outer_ear1.06380991
85MP0000613_abnormal_salivary_gland1.04986564
86MP0004133_heterotaxia1.03586697
87MP0003567_abnormal_fetal_cardiomyocyte1.03048846
88MP0001764_abnormal_homeostasis1.02506213
89MP0000013_abnormal_adipose_tissue1.02056957
90MP0002067_abnormal_sensory_capabilities1.00034161
91MP0002877_abnormal_melanocyte_morpholog0.99713200
92MP0002572_abnormal_emotion/affect_behav0.99105919
93MP0008789_abnormal_olfactory_epithelium0.98386339
94MP0000631_abnormal_neuroendocrine_gland0.98206338
95MP0006035_abnormal_mitochondrial_morpho0.97544124
96MP0003123_paternal_imprinting0.97426824
97MP0001486_abnormal_startle_reflex0.96465419
98MP0003698_abnormal_male_reproductive0.95014273
99MP0002752_abnormal_somatic_nervous0.94168850
100MP0000778_abnormal_nervous_system0.93962488
101MP0001485_abnormal_pinna_reflex0.93450028
102MP0002064_seizures0.93008388
103MP0002249_abnormal_larynx_morphology0.92791439
104MP0004270_analgesia0.92447934
105MP0002277_abnormal_respiratory_mucosa0.92063041
106MP0009250_abnormal_appendicular_skeleto0.91919115
107MP0009697_abnormal_copulation0.91899533
108MP0005369_muscle_phenotype0.90257945
109MP0002090_abnormal_vision0.90104545
110MP0005195_abnormal_posterior_eye0.89305647
111MP0002938_white_spotting0.88878598
112MP0001727_abnormal_embryo_implantation0.88615193
113MP0003122_maternal_imprinting0.88425921
114MP0000358_abnormal_cell_content/0.87593349
115MP0001286_abnormal_eye_development0.87337033
116MP0002063_abnormal_learning/memory/cond0.86908595
117MP0008872_abnormal_physiological_respon0.85784538
118MP0000516_abnormal_urinary_system0.85386562
119MP0005367_renal/urinary_system_phenotyp0.85386562
120MP0000681_abnormal_thyroid_gland0.84956159
121MP0001944_abnormal_pancreas_morphology0.83307801
122MP0002693_abnormal_pancreas_physiology0.83282277
123MP0000647_abnormal_sebaceous_gland0.82991943
124MP0004215_abnormal_myocardial_fiber0.82025203
125MP0002095_abnormal_skin_pigmentation0.81949115
126MP0005171_absent_coat_pigmentation0.80752895
127MP0003011_delayed_dark_adaptation0.80493932
128MP0003195_calcinosis0.77930851
129MP0005332_abnormal_amino_acid0.77756767
130MP0005646_abnormal_pituitary_gland0.77441840
131MP0005410_abnormal_fertilization0.77367047
132MP0002882_abnormal_neuron_morphology0.77249866
133MP0003890_abnormal_embryonic-extraembry0.77129064
134MP0003755_abnormal_palate_morphology0.76933474
135MP0000003_abnormal_adipose_tissue0.76685713
136MP0001919_abnormal_reproductive_system0.75774691
137MP0005391_vision/eye_phenotype0.75529560
138MP0001502_abnormal_circadian_rhythm0.75416950
139MP0003937_abnormal_limbs/digits/tail_de0.75362164
140MP0001879_abnormal_lymphatic_vessel0.75163988
141MP0005551_abnormal_eye_electrophysiolog0.74929304
142MP0005253_abnormal_eye_physiology0.74905350
143MP0008775_abnormal_heart_ventricle0.74764981
144MP0001963_abnormal_hearing_physiology0.73624572
145MP0000955_abnormal_spinal_cord0.73591066
146MP0004147_increased_porphyrin_level0.72884695

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)7.20853883
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35392259
3Acute necrotizing encephalopathy (HP:0006965)4.77781241
4Mitochondrial inheritance (HP:0001427)4.45458784
5Abnormal mitochondria in muscle tissue (HP:0008316)4.26417667
6Increased hepatocellular lipid droplets (HP:0006565)4.17324695
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.91276118
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91011000
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91011000
10Progressive macrocephaly (HP:0004481)3.88860044
11Renal Fanconi syndrome (HP:0001994)3.84536064
12Stenosis of the external auditory canal (HP:0000402)3.68183351
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65752823
14Increased CSF lactate (HP:0002490)3.63536519
15Exercise intolerance (HP:0003546)3.59262645
16Lipid accumulation in hepatocytes (HP:0006561)3.58238057
17Acute encephalopathy (HP:0006846)3.52024987
18Hepatocellular necrosis (HP:0001404)3.49540705
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37091600
20Conical tooth (HP:0000698)3.33428474
21Increased intramyocellular lipid droplets (HP:0012240)3.27085529
22Exertional dyspnea (HP:0002875)3.14437629
23Abnormal number of erythroid precursors (HP:0012131)2.99720009
24Pallor (HP:0000980)2.94023062
25Macrocytic anemia (HP:0001972)2.90058974
26Amniotic constriction ring (HP:0009775)2.88565275
27Abnormality of placental membranes (HP:0011409)2.88565275
28Lactic acidosis (HP:0003128)2.84473002
29Optic disc pallor (HP:0000543)2.82471014
30Hepatic necrosis (HP:0002605)2.82219957
31Abnormality of incisor morphology (HP:0011063)2.81973912
32Cerebral edema (HP:0002181)2.78708490
33Popliteal pterygium (HP:0009756)2.76717636
343-Methylglutaconic aciduria (HP:0003535)2.71316762
35Abnormality of renal resorption (HP:0011038)2.65449145
36Hyperglycinemia (HP:0002154)2.63283261
37Increased muscle lipid content (HP:0009058)2.59561492
38Retinal dysplasia (HP:0007973)2.59145314
39Generalized aminoaciduria (HP:0002909)2.56277391
40Abnormality of alanine metabolism (HP:0010916)2.51886956
41Hyperalaninemia (HP:0003348)2.51886956
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51886956
43Fetal akinesia sequence (HP:0001989)2.48435640
44Increased serum lactate (HP:0002151)2.46518976
45Aplasia/hypoplasia of the uterus (HP:0008684)2.45306103
46Respiratory failure (HP:0002878)2.42715280
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41406673
48Nephronophthisis (HP:0000090)2.38043583
49Colon cancer (HP:0003003)2.36314906
50Lethargy (HP:0001254)2.34523450
51Methylmalonic acidemia (HP:0002912)2.33021627
52Abnormality of the labia minora (HP:0012880)2.30425220
53Progressive muscle weakness (HP:0003323)2.30210686
54Hyperphosphaturia (HP:0003109)2.29513553
55Increased serum pyruvate (HP:0003542)2.27859885
56Abnormal hemoglobin (HP:0011902)2.27758807
57Septo-optic dysplasia (HP:0100842)2.21183740
58Abnormality of the anterior horn cell (HP:0006802)2.20486814
59Degeneration of anterior horn cells (HP:0002398)2.20486814
60Median cleft lip (HP:0000161)2.19541011
61Dry hair (HP:0011359)2.19214371
62Sclerocornea (HP:0000647)2.17253877
63Congenital, generalized hypertrichosis (HP:0004540)2.16574614
64Myokymia (HP:0002411)2.16398679
65Medial flaring of the eyebrow (HP:0010747)2.15381992
66Thickened helices (HP:0000391)2.15379662
67Abnormality of serum amino acid levels (HP:0003112)2.12861746
68Atelectasis (HP:0100750)2.12755381
69Meckel diverticulum (HP:0002245)2.10998049
70Type 2 muscle fiber atrophy (HP:0003554)2.08807909
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.08389469
72Respiratory difficulties (HP:0002880)2.07421440
73Facial cleft (HP:0002006)2.06308379
74Hypoplasia of the uterus (HP:0000013)2.04745341
75Glycosuria (HP:0003076)2.01649334
76Abnormality of urine glucose concentration (HP:0011016)2.01649334
77Testicular atrophy (HP:0000029)2.01470788
78Short tibia (HP:0005736)1.99517402
79Peripheral hypomyelination (HP:0007182)1.99096454
80Abnormality of the ileum (HP:0001549)1.98782539
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.98164780
82CNS demyelination (HP:0007305)1.97779147
83Supernumerary spleens (HP:0009799)1.96678130
84Methylmalonic aciduria (HP:0012120)1.96619238
85Pendular nystagmus (HP:0012043)1.96153189
86Abnormality of glycolysis (HP:0004366)1.94834100
87Hypoplastic heart (HP:0001961)1.93733719
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93696619
89Leukodystrophy (HP:0002415)1.91578596
90Reticulocytopenia (HP:0001896)1.90527739
91Abnormal urine phosphate concentration (HP:0012599)1.90161336
92Aplastic anemia (HP:0001915)1.90113230
93Muscle fiber atrophy (HP:0100295)1.86620951
94Postaxial foot polydactyly (HP:0001830)1.84996121
95Absent septum pellucidum (HP:0001331)1.84864815
96Anencephaly (HP:0002323)1.84451142
97Pancreatic fibrosis (HP:0100732)1.84033957
98Hyperglycinuria (HP:0003108)1.83535811
99Attenuation of retinal blood vessels (HP:0007843)1.83333708
100Congenital primary aphakia (HP:0007707)1.83216411
101Chromsome breakage (HP:0040012)1.81927442
102Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81496980
103Onycholysis (HP:0001806)1.80718730
104Abnormality of the renal medulla (HP:0100957)1.80591021
105Abnormality of methionine metabolism (HP:0010901)1.80396174
106Aplasia of the musculature (HP:0100854)1.79046736
107Muscle hypertrophy of the lower extremities (HP:0008968)1.78635701
108Absent eyebrow (HP:0002223)1.78373464
109Esotropia (HP:0000565)1.78302249
110Hypoplasia of the radius (HP:0002984)1.77181695
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.77067833
112Male pseudohermaphroditism (HP:0000037)1.76780542
113Pancreatic cysts (HP:0001737)1.76180037
114Gait imbalance (HP:0002141)1.76015328
115Triphalangeal thumb (HP:0001199)1.75120008
116Cerebral hypomyelination (HP:0006808)1.74500726
117Abnormal rod and cone electroretinograms (HP:0008323)1.73666461
118Nephrogenic diabetes insipidus (HP:0009806)1.73563116
119Abnormality of chromosome stability (HP:0003220)1.73438980
120Renal cortical cysts (HP:0000803)1.73157185
121Genital tract atresia (HP:0001827)1.71949147
122Oligodactyly (hands) (HP:0001180)1.71780470
123Vaginal atresia (HP:0000148)1.71755501
124Abnormal glycosylation (HP:0012345)1.70999482
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70999482
126Abnormal protein N-linked glycosylation (HP:0012347)1.70999482
127Abnormal protein glycosylation (HP:0012346)1.70999482
128Renal tubular dysfunction (HP:0000124)1.68970047
129Parakeratosis (HP:0001036)1.68516933
130Congenital ichthyosiform erythroderma (HP:0007431)1.68417689
131Sensory axonal neuropathy (HP:0003390)1.68300965
132Abnormality of the incisor (HP:0000676)1.68046561
133Ridged nail (HP:0001807)1.67577499
134True hermaphroditism (HP:0010459)1.65839199
135Absent thumb (HP:0009777)1.63891152
136Increased corneal curvature (HP:0100692)1.62471311
137Keratoconus (HP:0000563)1.62471311
138Abnormality of dental color (HP:0011073)1.62444655
139Limb dystonia (HP:0002451)1.62420871
140Nonprogressive disorder (HP:0003680)1.60327212
141Molar tooth sign on MRI (HP:0002419)1.59815297
142Abnormality of midbrain morphology (HP:0002418)1.59815297
143Hypothermia (HP:0002045)1.58835010
144Aplasia/Hypoplasia involving the musculature (HP:0001460)1.58355764
145Nemaline bodies (HP:0003798)1.58027863
146Horseshoe kidney (HP:0000085)1.56950844
147X-linked dominant inheritance (HP:0001423)1.55797429
148Poor suck (HP:0002033)1.55000574
149Neuroendocrine neoplasm (HP:0100634)1.54923051
150Type I transferrin isoform profile (HP:0003642)1.51816113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.96647132
2EIF2AK13.94749967
3TLK13.38290622
4ARAF3.03181538
5VRK22.99916314
6STK162.86449915
7CDC72.66902034
8NME22.59436812
9NEK12.49808423
10MKNK22.41670828
11EIF2AK32.40006354
12NME12.34335910
13PINK12.09474469
14BCKDK2.06719135
15PBK1.98826967
16BRAF1.91554165
17TNIK1.88962089
18MAP4K21.88689497
19TRIM281.84639933
20PLK41.80447401
21CASK1.77324129
22SRPK11.71604951
23PLK31.69074139
24MUSK1.68438285
25PIM21.61679479
26BMPR21.60392217
27MKNK11.58607341
28TTK1.57905395
29BMPR1B1.52585255
30ILK1.50957568
31STK391.46186760
32GRK71.45421438
33WEE11.42870752
34MAP2K71.40347696
35CCNB11.38529474
36FRK1.32530028
37MAP3K41.22960732
38CSNK1G21.22496051
39BCR1.21866640
40UHMK11.21165109
41CSNK1G11.21162303
42PDK21.21111539
43BRSK11.20301261
44VRK11.19776908
45CDK81.14952111
46MAP3K121.13219748
47ADRBK21.12518733
48ABL21.12511323
49PLK21.10511451
50ERBB31.07577368
51WNK41.06835183
52EIF2AK21.05788492
53AURKB1.05094778
54EPHB21.02052227
55GRK11.01921362
56CSNK1A1L1.01864284
57RPS6KB21.00537381
58PIK3CG0.99449884
59INSRR0.97086560
60MOS0.97077265
61AURKA0.95156070
62ROCK20.94917894
63BRSK20.94046508
64MAPKAPK50.91762246
65PTK2B0.91613525
66STK240.91598176
67DYRK30.89674441
68RPS6KA40.87258704
69CDK190.86989948
70DYRK20.84125414
71ATR0.83970546
72NEK20.83397529
73MAPK130.83394033
74EPHA40.82804793
75OXSR10.79441883
76ZAK0.78285328
77TAF10.76046431
78OBSCN0.73529752
79CDK30.72965136
80CAMK2B0.72914825
81IRAK20.70923073
82CAMK2D0.70704189
83CAMKK20.70219199
84RPS6KA50.69518164
85NUAK10.69069633
86MINK10.69008046
87RIPK40.68789711
88PRPF4B0.67008324
89IRAK30.66151381
90PAK10.65506054
91IRAK40.65345168
92STK38L0.64283418
93NEK60.63861258
94PHKG20.63818845
95PHKG10.63818845
96LIMK10.63269860
97WNK30.62160326
98PNCK0.61427504
99TIE10.60737519
100MAPK150.59292460
101ADRBK10.58168672
102IRAK10.56997401
103ATM0.56815784
104CSNK1E0.56517908
105MST40.54819836
106PRKCI0.53019191
107TESK20.50669273
108PKN10.49893012
109CAMK2A0.48919603
110DAPK10.48866532
111PRKCE0.48142678
112FLT30.47271655
113TSSK60.46479927
114TAOK30.45660508
115CHEK10.44825745
116NTRK30.44664069
117PRKCQ0.44069749
118CSNK2A10.43737589
119CAMK2G0.43274209
120MYLK0.43077905
121DYRK1A0.40890001
122PRKACB0.40750857
123GRK50.40659085
124PLK10.40023842
125NTRK20.39962108
126CDK140.39449770
127DAPK30.39098628
128TXK0.37736808
129MELK0.36025271
130CSNK1G30.33838181
131CHEK20.33106762
132CSNK2A20.33021079
133CSNK1A10.32633868
134FGR0.32559218
135MAP3K110.30554110
136RAF10.30174346
137CDK90.30041452
138MAP2K60.29756349
139PRKCG0.29558422
140PRKACA0.29176313

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.06251877
2Oxidative phosphorylation_Homo sapiens_hsa001904.60515355
3Parkinsons disease_Homo sapiens_hsa050124.09362717
4Proteasome_Homo sapiens_hsa030503.96222819
5Protein export_Homo sapiens_hsa030603.38824646
6RNA polymerase_Homo sapiens_hsa030203.13466705
7Alzheimers disease_Homo sapiens_hsa050103.10044270
8Huntingtons disease_Homo sapiens_hsa050162.98986485
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34734182
10Cardiac muscle contraction_Homo sapiens_hsa042601.97796966
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68710558
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62202507
13Propanoate metabolism_Homo sapiens_hsa006401.60550752
14Pyrimidine metabolism_Homo sapiens_hsa002401.51447969
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50629240
16One carbon pool by folate_Homo sapiens_hsa006701.48658541
17Homologous recombination_Homo sapiens_hsa034401.48362400
18Spliceosome_Homo sapiens_hsa030401.47791453
19Fatty acid elongation_Homo sapiens_hsa000621.42561937
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38392445
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31281287
22RNA degradation_Homo sapiens_hsa030181.24293769
23Basal transcription factors_Homo sapiens_hsa030221.22762395
24Butanoate metabolism_Homo sapiens_hsa006501.20981377
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14905987
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12648101
27Purine metabolism_Homo sapiens_hsa002301.10764191
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.08546389
29Vibrio cholerae infection_Homo sapiens_hsa051101.08145738
30Pyruvate metabolism_Homo sapiens_hsa006201.07455134
31Nicotine addiction_Homo sapiens_hsa050331.07198546
32Collecting duct acid secretion_Homo sapiens_hsa049661.06976933
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06257105
34Serotonergic synapse_Homo sapiens_hsa047261.05176939
35Fanconi anemia pathway_Homo sapiens_hsa034601.01830547
36Peroxisome_Homo sapiens_hsa041461.01451769
37Phototransduction_Homo sapiens_hsa047440.98834135
38Mismatch repair_Homo sapiens_hsa034300.98655381
39Nucleotide excision repair_Homo sapiens_hsa034200.94310843
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91828849
41Glutathione metabolism_Homo sapiens_hsa004800.88641613
42Sphingolipid metabolism_Homo sapiens_hsa006000.88390417
43DNA replication_Homo sapiens_hsa030300.88319786
44Sulfur metabolism_Homo sapiens_hsa009200.86691360
45Steroid biosynthesis_Homo sapiens_hsa001000.85469232
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84059602
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79619512
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79112382
49Graft-versus-host disease_Homo sapiens_hsa053320.78117459
50RNA transport_Homo sapiens_hsa030130.77861451
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76430759
52Cell cycle_Homo sapiens_hsa041100.74630153
53Rheumatoid arthritis_Homo sapiens_hsa053230.73602170
54Taste transduction_Homo sapiens_hsa047420.73357110
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73103779
56Selenocompound metabolism_Homo sapiens_hsa004500.71370315
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69502488
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.68513708
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68076271
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67074108
61Type I diabetes mellitus_Homo sapiens_hsa049400.66721170
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66619027
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66149815
64Dorso-ventral axis formation_Homo sapiens_hsa043200.65892673
65Phagosome_Homo sapiens_hsa041450.62919186
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61544084
67Arachidonic acid metabolism_Homo sapiens_hsa005900.60966382
68beta-Alanine metabolism_Homo sapiens_hsa004100.60576854
69Ether lipid metabolism_Homo sapiens_hsa005650.60490207
70Regulation of autophagy_Homo sapiens_hsa041400.59410683
71Long-term depression_Homo sapiens_hsa047300.59150432
72Fatty acid metabolism_Homo sapiens_hsa012120.59025976
73Fatty acid degradation_Homo sapiens_hsa000710.58692897
74Carbon metabolism_Homo sapiens_hsa012000.58634345
75Chemical carcinogenesis_Homo sapiens_hsa052040.58310728
76Alcoholism_Homo sapiens_hsa050340.57583648
77Autoimmune thyroid disease_Homo sapiens_hsa053200.56315013
78Synaptic vesicle cycle_Homo sapiens_hsa047210.55702460
79Allograft rejection_Homo sapiens_hsa053300.54374266
80Tryptophan metabolism_Homo sapiens_hsa003800.53386856
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.53244306
82Long-term potentiation_Homo sapiens_hsa047200.53090570
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52973036
84Morphine addiction_Homo sapiens_hsa050320.52662894
85Non-homologous end-joining_Homo sapiens_hsa034500.51738737
86Asthma_Homo sapiens_hsa053100.50343646
87Circadian entrainment_Homo sapiens_hsa047130.50070885
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49280597
89Caffeine metabolism_Homo sapiens_hsa002320.47743701
90Linoleic acid metabolism_Homo sapiens_hsa005910.46901181
91Retinol metabolism_Homo sapiens_hsa008300.46371059
92Insulin secretion_Homo sapiens_hsa049110.46370674
93Glutamatergic synapse_Homo sapiens_hsa047240.46210422
94Axon guidance_Homo sapiens_hsa043600.45944614
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.45936908
96Arginine and proline metabolism_Homo sapiens_hsa003300.45392014
97Vitamin B6 metabolism_Homo sapiens_hsa007500.45019734
98Epstein-Barr virus infection_Homo sapiens_hsa051690.44374337
99Cholinergic synapse_Homo sapiens_hsa047250.43767233
100Amphetamine addiction_Homo sapiens_hsa050310.43503651
101GnRH signaling pathway_Homo sapiens_hsa049120.40782715
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.40716210
103Dopaminergic synapse_Homo sapiens_hsa047280.40325564
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40076666
105GABAergic synapse_Homo sapiens_hsa047270.39539123
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39176802
107Metabolic pathways_Homo sapiens_hsa011000.38710204
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38196005
109Renal cell carcinoma_Homo sapiens_hsa052110.37813056
110Gap junction_Homo sapiens_hsa045400.36183302
111Biosynthesis of amino acids_Homo sapiens_hsa012300.36040011
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35575457
113Nitrogen metabolism_Homo sapiens_hsa009100.35396317
114Ras signaling pathway_Homo sapiens_hsa040140.35189288
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34768696
116Wnt signaling pathway_Homo sapiens_hsa043100.34535386
117Oocyte meiosis_Homo sapiens_hsa041140.33559504
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33421584
119Folate biosynthesis_Homo sapiens_hsa007900.33082820
120Sulfur relay system_Homo sapiens_hsa041220.32898044
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32653817
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32584353
123Calcium signaling pathway_Homo sapiens_hsa040200.32138768
124Tyrosine metabolism_Homo sapiens_hsa003500.29461109
125Systemic lupus erythematosus_Homo sapiens_hsa053220.29278151
126mRNA surveillance pathway_Homo sapiens_hsa030150.29072639
127Hedgehog signaling pathway_Homo sapiens_hsa043400.28643204
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28498795
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.28218910
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28007808
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26543398
132Circadian rhythm_Homo sapiens_hsa047100.26021107
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25981676
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25809267
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24942603
136Melanogenesis_Homo sapiens_hsa049160.24792039
137Salmonella infection_Homo sapiens_hsa051320.24364418
138p53 signaling pathway_Homo sapiens_hsa041150.23505276
139Oxytocin signaling pathway_Homo sapiens_hsa049210.22845495
140Base excision repair_Homo sapiens_hsa034100.22522100
141Olfactory transduction_Homo sapiens_hsa047400.22364892
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21210376
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21192400
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20048739
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19054742
146Cocaine addiction_Homo sapiens_hsa050300.19008195
147Phenylalanine metabolism_Homo sapiens_hsa003600.18593667
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16599044

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