ZCWPW2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.04496651
2negative regulation of telomere maintenance (GO:0032205)4.72113483
3gamma-aminobutyric acid transport (GO:0015812)4.65719920
4DNA deamination (GO:0045006)4.64149909
5behavioral response to nicotine (GO:0035095)4.41081788
6negative regulation of synaptic transmission, GABAergic (GO:0032229)4.40433868
7protein localization to synapse (GO:0035418)4.35974558
8fucose catabolic process (GO:0019317)4.31919075
9L-fucose metabolic process (GO:0042354)4.31919075
10L-fucose catabolic process (GO:0042355)4.31919075
11motile cilium assembly (GO:0044458)4.30233600
12cellular sodium ion homeostasis (GO:0006883)4.15122482
13vocalization behavior (GO:0071625)4.13610597
14synaptic vesicle exocytosis (GO:0016079)4.08108529
15sodium ion export (GO:0071436)4.03614718
16artery smooth muscle contraction (GO:0014824)4.00515004
17gamma-aminobutyric acid signaling pathway (GO:0007214)4.00019231
18amino acid import (GO:0043090)3.88106766
19presynaptic membrane assembly (GO:0097105)3.84645056
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84517171
21response to pheromone (GO:0019236)3.82862455
22kynurenine metabolic process (GO:0070189)3.81468633
23neurotransmitter uptake (GO:0001504)3.76639061
24C4-dicarboxylate transport (GO:0015740)3.75675890
25indolalkylamine metabolic process (GO:0006586)3.73442950
26indole-containing compound catabolic process (GO:0042436)3.70104496
27indolalkylamine catabolic process (GO:0046218)3.70104496
28tryptophan catabolic process (GO:0006569)3.70104496
29axoneme assembly (GO:0035082)3.68691764
30protein complex biogenesis (GO:0070271)3.68075438
31tryptophan metabolic process (GO:0006568)3.63519304
32platelet dense granule organization (GO:0060155)3.62042867
33tonic smooth muscle contraction (GO:0014820)3.61540250
34neuron cell-cell adhesion (GO:0007158)3.59837048
35positive regulation of muscle hypertrophy (GO:0014742)3.59267350
36positive regulation of cardiac muscle hypertrophy (GO:0010613)3.59267350
37acrosome assembly (GO:0001675)3.54899977
38respiratory chain complex IV assembly (GO:0008535)3.47037593
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.42067894
40NADH dehydrogenase complex assembly (GO:0010257)3.42067894
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42067894
42potassium ion homeostasis (GO:0055075)3.40668688
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39059471
44cellular ketone body metabolic process (GO:0046950)3.38979270
45water-soluble vitamin biosynthetic process (GO:0042364)3.36262026
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36259624
47mitochondrial respiratory chain complex assembly (GO:0033108)3.36216680
48potassium ion import (GO:0010107)3.34598976
49regulation of hexokinase activity (GO:1903299)3.33459580
50regulation of glucokinase activity (GO:0033131)3.33459580
51cell communication by electrical coupling (GO:0010644)3.33065094
52piRNA metabolic process (GO:0034587)3.29075339
53preassembly of GPI anchor in ER membrane (GO:0016254)3.28484423
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26285864
55opioid receptor signaling pathway (GO:0038003)3.26183380
56L-amino acid import (GO:0043092)3.20000390
57regulation of cardiac muscle cell contraction (GO:0086004)3.19846535
58neuronal action potential propagation (GO:0019227)3.18825534
59postsynaptic membrane organization (GO:0001941)3.18303004
60neurotransmitter secretion (GO:0007269)3.17144679
61neurotransmitter-gated ion channel clustering (GO:0072578)3.16892583
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.16534870
63cytochrome complex assembly (GO:0017004)3.15266278
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14214180
65peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.13910284
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12711677
67protein polyglutamylation (GO:0018095)3.12510774
68presynaptic membrane organization (GO:0097090)3.11807774
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09649332
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08328760
71detection of light stimulus involved in sensory perception (GO:0050962)3.07535174
72detection of light stimulus involved in visual perception (GO:0050908)3.07535174
73S-adenosylmethionine metabolic process (GO:0046500)3.04911541
74acrosome reaction (GO:0007340)3.04746153
75sodium ion homeostasis (GO:0055078)3.04630972
76ketone body metabolic process (GO:1902224)3.03437386
77mannosylation (GO:0097502)3.02696278
78vascular smooth muscle contraction (GO:0014829)3.01895282
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01876253
80striatum development (GO:0021756)3.00214301
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99472979
82alanine transport (GO:0032328)2.97200758
83succinate metabolic process (GO:0006105)2.93830421
84cellular response to ATP (GO:0071318)2.92848516
85protein neddylation (GO:0045116)2.91874627
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91637834
87regulation of telomere maintenance (GO:0032204)2.90476604
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89980974
89positive regulation of prostaglandin secretion (GO:0032308)2.89503917
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88553919
91ATP hydrolysis coupled proton transport (GO:0015991)2.88553919
92regulation of cilium movement (GO:0003352)2.87625432
93indole-containing compound metabolic process (GO:0042430)2.85861339
94urinary tract smooth muscle contraction (GO:0014848)2.85665289
95neurotransmitter transport (GO:0006836)2.85093953
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84411921
97ubiquinone biosynthetic process (GO:0006744)2.83033124
98regulation of meiosis I (GO:0060631)2.81752142
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81670852
100proline transport (GO:0015824)2.81455434
101neurotransmitter catabolic process (GO:0042135)2.80943289
102protein-cofactor linkage (GO:0018065)2.80536313
103response to auditory stimulus (GO:0010996)2.79531378
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79085512
105regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78676513
106multicellular organism reproduction (GO:0032504)2.78063002
107amino acid salvage (GO:0043102)2.77742477
108L-methionine salvage (GO:0071267)2.77742477
109L-methionine biosynthetic process (GO:0071265)2.77742477
110neuron-neuron synaptic transmission (GO:0007270)2.77687551
111regulation of respiratory system process (GO:0044065)2.77116851
112exploration behavior (GO:0035640)2.77075266
113serotonin receptor signaling pathway (GO:0007210)2.76443136
114response to acidic pH (GO:0010447)2.75232375
115ionotropic glutamate receptor signaling pathway (GO:0035235)2.75057535
116glutamate secretion (GO:0014047)2.74900447
117synaptic transmission, glutamatergic (GO:0035249)2.74731591
118dopamine transport (GO:0015872)2.74718013
119adenosine metabolic process (GO:0046085)2.74405727
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74119348
121membrane depolarization during action potential (GO:0086010)2.73021655
122regulation of neurotransmitter levels (GO:0001505)2.72930522
123mechanosensory behavior (GO:0007638)2.71951523
124regulation of voltage-gated calcium channel activity (GO:1901385)2.71129440
125ATP synthesis coupled proton transport (GO:0015986)2.70683323
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70683323
127protein localization to cilium (GO:0061512)2.70364921
128glycerophospholipid catabolic process (GO:0046475)2.70010412
129low-density lipoprotein particle remodeling (GO:0034374)2.69884995
130innervation (GO:0060384)2.69594495
131regulation of synaptic vesicle exocytosis (GO:2000300)2.69400324
132cilium morphogenesis (GO:0060271)2.68495996
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68455279
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68455279
135glutamate receptor signaling pathway (GO:0007215)2.67385016
136regulation of activation of Janus kinase activity (GO:0010533)2.67343560
137branched-chain amino acid catabolic process (GO:0009083)2.66310167
138replication fork processing (GO:0031297)2.66186866
139negative regulation of reactive oxygen species metabolic process (GO:2000378)2.64626678
140auditory behavior (GO:0031223)2.63503252
141GPI anchor metabolic process (GO:0006505)2.63063670
142inositol phosphate catabolic process (GO:0071545)2.62414904
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61666385
144regulation of action potential (GO:0098900)2.61576039
145drinking behavior (GO:0042756)2.61261619
146epithelial cilium movement (GO:0003351)2.61074273
147signal peptide processing (GO:0006465)2.60847619
148peristalsis (GO:0030432)2.60749759
149long-term synaptic potentiation (GO:0060291)2.60612757
150retinal cone cell development (GO:0046549)2.60201793
151neural tube formation (GO:0001841)2.60071751
152DNA methylation involved in gamete generation (GO:0043046)2.60070751
153positive regulation of fatty acid transport (GO:2000193)2.59254412
154transmission of nerve impulse (GO:0019226)2.58676254
155electron transport chain (GO:0022900)2.58552358
156neuronal ion channel clustering (GO:0045161)2.57833505
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57483818
158regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56887858
159negative regulation of mast cell activation (GO:0033004)2.56670814
160ubiquinone metabolic process (GO:0006743)2.56190383
161regulation of telomere maintenance via telomerase (GO:0032210)2.55821435
162response to histamine (GO:0034776)2.54650084
163cellular potassium ion transport (GO:0071804)2.54264286
164potassium ion transmembrane transport (GO:0071805)2.54264286
165amine catabolic process (GO:0009310)2.54250509
166cellular biogenic amine catabolic process (GO:0042402)2.54250509
167negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53965570
168ER overload response (GO:0006983)2.53850168
169calcium ion-dependent exocytosis (GO:0017156)2.52979291
170sperm motility (GO:0030317)2.52508400
171kidney morphogenesis (GO:0060993)2.51676039
172nucleoside diphosphate catabolic process (GO:0009134)2.51654531
173respiratory electron transport chain (GO:0022904)2.49717978
174acidic amino acid transport (GO:0015800)2.49665220
175positive regulation of action potential (GO:0045760)2.49406047
176positive regulation of heart rate (GO:0010460)2.48783231
177nonmotile primary cilium assembly (GO:0035058)2.48545865
178cell wall macromolecule catabolic process (GO:0016998)2.48481377
179cell wall macromolecule metabolic process (GO:0044036)2.48481377
180positive regulation of meiosis (GO:0045836)2.47773926
181protein K6-linked ubiquitination (GO:0085020)2.47523358
182inositol phosphate dephosphorylation (GO:0046855)2.47417942
183phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47417942
184benzene-containing compound metabolic process (GO:0042537)2.47270987
185rRNA catabolic process (GO:0016075)2.47206332
186neuromuscular synaptic transmission (GO:0007274)2.47115644
187magnesium ion transport (GO:0015693)2.46756226
188male meiosis I (GO:0007141)2.46032979
189nucleotide transmembrane transport (GO:1901679)2.45670143
190male meiosis (GO:0007140)2.45579624
191primary amino compound metabolic process (GO:1901160)2.45567566
192regulation of vesicle fusion (GO:0031338)2.44918120
193cytidine metabolic process (GO:0046087)2.43747755
194cytidine catabolic process (GO:0006216)2.43747755
195cytidine deamination (GO:0009972)2.43747755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40358294
2ZNF274_21170338_ChIP-Seq_K562_Hela3.95193938
3GBX2_23144817_ChIP-Seq_PC3_Human3.89708640
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90376170
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90052159
6TAF15_26573619_Chip-Seq_HEK293_Human2.51356890
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48413822
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39063062
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38254191
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23571374
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20595583
12VDR_22108803_ChIP-Seq_LS180_Human2.14157162
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.11448261
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11386637
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03933966
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98082180
17EWS_26573619_Chip-Seq_HEK293_Human1.96807505
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95462783
19IGF1R_20145208_ChIP-Seq_DFB_Human1.95244420
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93632549
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.93354998
22REST_21632747_ChIP-Seq_MESCs_Mouse1.91166374
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90350673
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.87051062
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86986122
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86352281
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84950281
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84742725
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.83265744
30P300_19829295_ChIP-Seq_ESCs_Human1.83264140
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81400377
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81302542
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80562053
34SMAD4_21799915_ChIP-Seq_A2780_Human1.80083621
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77399752
36AR_21572438_ChIP-Seq_LNCaP_Human1.75542089
37FUS_26573619_Chip-Seq_HEK293_Human1.75385981
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75026068
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72399078
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72399078
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71754226
42TP53_22573176_ChIP-Seq_HFKS_Human1.67377669
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.67019033
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.66029877
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.65887610
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63842760
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63690819
48DROSHA_22980978_ChIP-Seq_HELA_Human1.61048402
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.59392123
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59278329
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.54624919
52* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52043603
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51931944
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50988575
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.50935116
56AR_25329375_ChIP-Seq_VCAP_Human1.50780927
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50637880
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.48136706
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47844006
60IRF1_19129219_ChIP-ChIP_H3396_Human1.46134354
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45534129
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.45435452
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45046380
64SOX2_19829295_ChIP-Seq_ESCs_Human1.43864630
65NANOG_19829295_ChIP-Seq_ESCs_Human1.43864630
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43122281
67BCAT_22108803_ChIP-Seq_LS180_Human1.41200144
68MYC_18940864_ChIP-ChIP_HL60_Human1.40821490
69ELK1_19687146_ChIP-ChIP_HELA_Human1.39732805
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39309637
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.39223636
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38231260
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35916508
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.35859952
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35824883
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35471255
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35407888
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.34950855
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.34454256
80AR_20517297_ChIP-Seq_VCAP_Human1.33787672
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31780574
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30800230
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.30800230
84TP53_18474530_ChIP-ChIP_U2OS_Human1.29932009
85RNF2_27304074_Chip-Seq_NSC_Mouse1.29665463
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29661187
87TCF4_22108803_ChIP-Seq_LS180_Human1.28974746
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28933104
89VDR_23849224_ChIP-Seq_CD4+_Human1.28009220
90* STAT3_23295773_ChIP-Seq_U87_Human1.27443582
91KDM2B_26808549_Chip-Seq_REH_Human1.27095185
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26820378
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26360581
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25913485
95JUN_21703547_ChIP-Seq_K562_Human1.25418683
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24937937
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24198590
98NCOR_22424771_ChIP-Seq_293T_Human1.22420071
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21972310
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21848980
101* TCF4_23295773_ChIP-Seq_U87_Human1.21778421
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.21524142
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21505503
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.21054399
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21040413
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20729365
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.20724910
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19872185
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18530719
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.18205022
111* RUNX2_22187159_ChIP-Seq_PCA_Human1.17833230
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17130806
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.16711909
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16350771
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16350771
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16334641
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16287604
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15310380
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14996300
120* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14613628
121* ER_23166858_ChIP-Seq_MCF-7_Human1.14223874
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13293702
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11260701
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.11081349
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10007424
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.09698503
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09577499
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.09200673
129HOXB7_26014856_ChIP-Seq_BT474_Human1.08958630
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08519900
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08015418
132TP53_16413492_ChIP-PET_HCT116_Human1.07195262
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06480848
134YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06327477
135GATA1_22025678_ChIP-Seq_K562_Human1.06090835
136CDX2_22108803_ChIP-Seq_LS180_Human1.05988092
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05504596
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05504596
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.05161194
140PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05046194
141CMYC_18555785_Chip-Seq_ESCs_Mouse1.04969521
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03908155
143CBP_20019798_ChIP-Seq_JUKART_Human1.03908155
144FOXH1_21741376_ChIP-Seq_EPCs_Human1.03277443
145P53_22387025_ChIP-Seq_ESCs_Mouse1.03214031
146SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02704404
147HTT_18923047_ChIP-ChIP_STHdh_Human1.02154945
148AHR_22903824_ChIP-Seq_MCF-7_Human1.01080178
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.00823206
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00184276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia4.47678756
2MP0005423_abnormal_somatic_nervous3.56473746
3MP0003195_calcinosis3.49949730
4MP0001986_abnormal_taste_sensitivity3.32538812
5MP0002837_dystrophic_cardiac_calcinosis3.21865743
6MP0001984_abnormal_olfaction3.18052446
7MP0009046_muscle_twitch3.08335911
8MP0009745_abnormal_behavioral_response2.93467417
9MP0001968_abnormal_touch/_nociception2.88106298
10MP0002102_abnormal_ear_morphology2.87637454
11MP0004147_increased_porphyrin_level2.84879668
12MP0002734_abnormal_mechanical_nocicepti2.63195653
13MP0003880_abnormal_central_pattern2.62352603
14MP0002736_abnormal_nociception_after2.60876786
15MP0004859_abnormal_synaptic_plasticity2.60497161
16MP0009384_cardiac_valve_regurgitation2.53568234
17MP0003646_muscle_fatigue2.50070917
18MP0002735_abnormal_chemical_nociception2.44646336
19MP0002138_abnormal_hepatobiliary_system2.44336187
20MP0003136_yellow_coat_color2.42585629
21MP0004885_abnormal_endolymph2.40393095
22MP0002064_seizures2.37310274
23MP0005394_taste/olfaction_phenotype2.34995482
24MP0005499_abnormal_olfactory_system2.34995482
25MP0003635_abnormal_synaptic_transmissio2.34976432
26MP0005670_abnormal_white_adipose2.33721486
27MP0001486_abnormal_startle_reflex2.29702535
28MP0008875_abnormal_xenobiotic_pharmacok2.23680247
29MP0002272_abnormal_nervous_system2.19668537
30MP0002572_abnormal_emotion/affect_behav2.11315555
31MP0001501_abnormal_sleep_pattern2.10963043
32MP0005646_abnormal_pituitary_gland2.08023599
33MP0002063_abnormal_learning/memory/cond2.04484801
34MP0005377_hearing/vestibular/ear_phenot1.92967235
35MP0003878_abnormal_ear_physiology1.92967235
36MP0003011_delayed_dark_adaptation1.91534540
37MP0008775_abnormal_heart_ventricle1.91467437
38MP0005410_abnormal_fertilization1.86246899
39MP0004145_abnormal_muscle_electrophysio1.84869207
40MP0005645_abnormal_hypothalamus_physiol1.83532772
41MP0002163_abnormal_gland_morphology1.79777123
42MP0002638_abnormal_pupillary_reflex1.76429002
43MP0001970_abnormal_pain_threshold1.73602374
44MP0005171_absent_coat_pigmentation1.70960437
45MP0002067_abnormal_sensory_capabilities1.70540216
46MP0002733_abnormal_thermal_nociception1.70051510
47MP0003879_abnormal_hair_cell1.70037063
48MP0005503_abnormal_tendon_morphology1.65001581
49MP0000427_abnormal_hair_cycle1.63217776
50MP0001440_abnormal_grooming_behavior1.59606514
51MP0004215_abnormal_myocardial_fiber1.59216701
52MP0001502_abnormal_circadian_rhythm1.58543216
53MP0005551_abnormal_eye_electrophysiolog1.55608402
54MP0008569_lethality_at_weaning1.53753863
55MP0004133_heterotaxia1.49023247
56MP0003690_abnormal_glial_cell1.41522743
57MP0006292_abnormal_olfactory_placode1.40985373
58MP0006276_abnormal_autonomic_nervous1.39821102
59MP0002557_abnormal_social/conspecific_i1.38464679
60MP0002938_white_spotting1.37667441
61MP0009780_abnormal_chondrocyte_physiolo1.37044097
62MP0001485_abnormal_pinna_reflex1.36171217
63MP0005389_reproductive_system_phenotype1.36098205
64MP0000372_irregular_coat_pigmentation1.35816973
65MP0004142_abnormal_muscle_tone1.29642740
66MP0003137_abnormal_impulse_conducting1.29064952
67MP0009697_abnormal_copulation1.28905575
68MP0010386_abnormal_urinary_bladder1.28061706
69MP0000751_myopathy1.27395931
70MP0003787_abnormal_imprinting1.26531032
71MP0001919_abnormal_reproductive_system1.25725674
72MP0003950_abnormal_plasma_membrane1.24576560
73MP0000569_abnormal_digit_pigmentation1.24385551
74MP0001963_abnormal_hearing_physiology1.19890121
75MP0002909_abnormal_adrenal_gland1.17726460
76MP0002876_abnormal_thyroid_physiology1.16013945
77MP0005332_abnormal_amino_acid1.15574885
78MP0003633_abnormal_nervous_system1.11967456
79MP0002277_abnormal_respiratory_mucosa1.11656489
80MP0000230_abnormal_systemic_arterial1.08819122
81MP0003283_abnormal_digestive_organ1.07287953
82MP0003279_aneurysm1.06735875
83MP0005253_abnormal_eye_physiology1.06264702
84MP0004084_abnormal_cardiac_muscle1.06175431
85MP0004858_abnormal_nervous_system1.06101367
86MP0003634_abnormal_glial_cell1.04802548
87MP0005379_endocrine/exocrine_gland_phen1.04397258
88MP0001188_hyperpigmentation1.04103650
89MP0006036_abnormal_mitochondrial_physio1.02869910
90MP0000013_abnormal_adipose_tissue1.02813949
91MP0008995_early_reproductive_senescence1.02489178
92MP0005075_abnormal_melanosome_morpholog1.02095393
93MP0003698_abnormal_male_reproductive1.00794536
94MP0000778_abnormal_nervous_system0.99769044
95MP0002928_abnormal_bile_duct0.98467447
96MP0002160_abnormal_reproductive_system0.97243777
97MP0003252_abnormal_bile_duct0.96931208
98MP0008877_abnormal_DNA_methylation0.96901291
99MP0005386_behavior/neurological_phenoty0.96642433
100MP0004924_abnormal_behavior0.96642433
101MP0002822_catalepsy0.96369324
102MP0002882_abnormal_neuron_morphology0.96356731
103MP0000647_abnormal_sebaceous_gland0.95951802
104MP0010329_abnormal_lipoprotein_level0.95556256
105MP0002234_abnormal_pharynx_morphology0.95338324
106MP0002127_abnormal_cardiovascular_syste0.94220767
107MP0003806_abnormal_nucleotide_metabolis0.93100635
108MP0003718_maternal_effect0.92694011
109MP0003631_nervous_system_phenotype0.92268389
110MP0001529_abnormal_vocalization0.92230466
111MP0004043_abnormal_pH_regulation0.92065541
112MP0002184_abnormal_innervation0.91507060
113MP0006035_abnormal_mitochondrial_morpho0.89525079
114MP0003186_abnormal_redox_activity0.89466680
115MP0002066_abnormal_motor_capabilities/c0.89242566
116MP0006072_abnormal_retinal_apoptosis0.88807071
117MP0002229_neurodegeneration0.88382334
118MP0005636_abnormal_mineral_homeostasis0.87748961
119MP0005195_abnormal_posterior_eye0.87468239
120MP0008872_abnormal_physiological_respon0.86683465
121MP0005085_abnormal_gallbladder_physiolo0.85126436
122MP0005220_abnormal_exocrine_pancreas0.84265413
123MP0005084_abnormal_gallbladder_morpholo0.82948203
124MP0000383_abnormal_hair_follicle0.82162197
125MP0002693_abnormal_pancreas_physiology0.79841057
126MP0008789_abnormal_olfactory_epithelium0.79422785
127MP0004742_abnormal_vestibular_system0.78543058
128MP0001764_abnormal_homeostasis0.78357279
129MP0005165_increased_susceptibility_to0.77965818
130MP0000613_abnormal_salivary_gland0.76336987
131MP0003786_premature_aging0.75424483
132MP0001905_abnormal_dopamine_level0.74988178
133MP0002751_abnormal_autonomic_nervous0.74674550
134MP0000026_abnormal_inner_ear0.72932612
135MP0004085_abnormal_heartbeat0.72682703
136MP0008874_decreased_physiological_sensi0.72283426
137MP0000566_synostosis0.72166705
138MP0002332_abnormal_exercise_endurance0.67367418
139MP0003075_altered_response_to0.67117610
140MP0001664_abnormal_digestion0.66276536
141MP0003329_amyloid_beta_deposits0.65634758
142MP0001177_atelectasis0.64986245
143MP0000955_abnormal_spinal_cord0.64829879
144MP0004484_altered_response_of0.64776469
145MP0005167_abnormal_blood-brain_barrier0.63404540
146MP0005409_darkened_coat_color0.62964380
147MP0002108_abnormal_muscle_morphology0.62514965
148MP0002752_abnormal_somatic_nervous0.62083758
149MP0002972_abnormal_cardiac_muscle0.61673185
150MP0000631_abnormal_neuroendocrine_gland0.61620316

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.71479272
2Epileptic encephalopathy (HP:0200134)4.56937266
3Pancreatic cysts (HP:0001737)4.14661527
4Abnormality of midbrain morphology (HP:0002418)4.01743323
5Molar tooth sign on MRI (HP:0002419)4.01743323
6Atonic seizures (HP:0010819)4.00645457
7Abnormality of binocular vision (HP:0011514)3.98855432
8Diplopia (HP:0000651)3.98855432
9Febrile seizures (HP:0002373)3.96054331
10Medial flaring of the eyebrow (HP:0010747)3.83370520
11Hemiparesis (HP:0001269)3.78658768
12Hemiplegia (HP:0002301)3.76794687
13Congenital stationary night blindness (HP:0007642)3.61772187
14Abnormality of the renal cortex (HP:0011035)3.58199445
15Gait imbalance (HP:0002141)3.51763942
16Congenital, generalized hypertrichosis (HP:0004540)3.50022304
17Hyperventilation (HP:0002883)3.39478783
18Congenital primary aphakia (HP:0007707)3.38885761
19Methylmalonic acidemia (HP:0002912)3.38620886
20Absent/shortened dynein arms (HP:0200106)3.36594649
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.36594649
22Hypothermia (HP:0002045)3.18643810
23Generalized tonic-clonic seizures (HP:0002069)3.17620149
24Nephrogenic diabetes insipidus (HP:0009806)3.14973111
25Abnormality of the renal medulla (HP:0100957)3.12147362
26Aplasia involving bones of the upper limbs (HP:0009823)3.06239469
27Aplasia of the phalanges of the hand (HP:0009802)3.06239469
28Aplasia involving bones of the extremities (HP:0009825)3.06239469
29Type II lissencephaly (HP:0007260)3.05873605
30Abnormal respiratory motile cilium morphology (HP:0005938)3.02547432
31Abnormal respiratory epithelium morphology (HP:0012253)3.02547432
32Abolished electroretinogram (ERG) (HP:0000550)3.01561611
33Renal cortical cysts (HP:0000803)2.97580744
34Retinal dysplasia (HP:0007973)2.95745942
35Mitochondrial inheritance (HP:0001427)2.92194210
36Attenuation of retinal blood vessels (HP:0007843)2.84584311
37Neuroendocrine neoplasm (HP:0100634)2.82812172
38Increased CSF lactate (HP:0002490)2.82809270
39Abnormal ciliary motility (HP:0012262)2.82413933
40Polydipsia (HP:0001959)2.73945303
41Abnormal drinking behavior (HP:0030082)2.73945303
42Large for gestational age (HP:0001520)2.73816309
43Hepatic necrosis (HP:0002605)2.69702009
44Abnormality of renal resorption (HP:0011038)2.68324731
45Renal Fanconi syndrome (HP:0001994)2.64280150
46Pancreatic islet-cell hyperplasia (HP:0004510)2.63909802
47Absence seizures (HP:0002121)2.63143371
48Abnormal respiratory motile cilium physiology (HP:0012261)2.59873415
49Progressive cerebellar ataxia (HP:0002073)2.59369962
50Acute encephalopathy (HP:0006846)2.55516508
51Narrow nasal bridge (HP:0000446)2.54785397
52Abnormal rod and cone electroretinograms (HP:0008323)2.53920835
53Myokymia (HP:0002411)2.53671246
54Genital tract atresia (HP:0001827)2.52737291
553-Methylglutaconic aciduria (HP:0003535)2.48240774
56Chronic hepatic failure (HP:0100626)2.46914936
57Focal seizures (HP:0007359)2.46195377
58Abnormal hair whorl (HP:0010721)2.46180505
59Hypomagnesemia (HP:0002917)2.46170199
60Aplasia/Hypoplasia of the lens (HP:0008063)2.45836281
61Follicular hyperkeratosis (HP:0007502)2.45167535
62Poor coordination (HP:0002370)2.45030356
63Status epilepticus (HP:0002133)2.44858197
64Megalencephaly (HP:0001355)2.44630091
65Hepatocellular necrosis (HP:0001404)2.44413828
66Cystic liver disease (HP:0006706)2.43076408
67Vaginal atresia (HP:0000148)2.42957078
68Tubular atrophy (HP:0000092)2.42608349
69Hyperinsulinemic hypoglycemia (HP:0000825)2.40793093
70Methylmalonic aciduria (HP:0012120)2.39385947
71Action tremor (HP:0002345)2.35340028
72Pheochromocytoma (HP:0002666)2.33642871
73Keratoconus (HP:0000563)2.31523282
74Increased corneal curvature (HP:0100692)2.31523282
75Dialeptic seizures (HP:0011146)2.27042419
76Broad-based gait (HP:0002136)2.26826516
77Fair hair (HP:0002286)2.26699650
78Abnormality of vitamin B metabolism (HP:0004340)2.26481275
79Synostosis involving the elbow (HP:0003938)2.26431927
80Humeroradial synostosis (HP:0003041)2.26431927
81Renal tubular acidosis (HP:0001947)2.26430170
82Polyuria (HP:0000103)2.26306677
83Blue irides (HP:0000635)2.25458454
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24791546
85Median cleft lip (HP:0000161)2.20867847
86Optic disc pallor (HP:0000543)2.20652721
87Furrowed tongue (HP:0000221)2.16052052
88Gaze-evoked nystagmus (HP:0000640)2.15649323
89Hypoplastic left heart (HP:0004383)2.14330398
90Abnormality of the vitamin B12 metabolism (HP:0004341)2.14190896
91Confusion (HP:0001289)2.14142520
92Aplasia/hypoplasia of the uterus (HP:0008684)2.11453856
93Glycosuria (HP:0003076)2.10471188
94Abnormality of urine glucose concentration (HP:0011016)2.10471188
95Anxiety (HP:0000739)2.09857643
96Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09562018
97Pendular nystagmus (HP:0012043)2.09011280
98Limb dystonia (HP:0002451)2.08705471
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.08235910
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.07201423
101Ketoacidosis (HP:0001993)2.06619840
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05766009
103Abnormality of alanine metabolism (HP:0010916)2.05766009
104Hyperalaninemia (HP:0003348)2.05766009
105Decreased central vision (HP:0007663)2.05694418
106Hypoglycemic coma (HP:0001325)2.04230254
107Increased hepatocellular lipid droplets (HP:0006565)2.03633678
108Congenital hepatic fibrosis (HP:0002612)2.03488790
109Bile duct proliferation (HP:0001408)2.03438583
110Abnormal biliary tract physiology (HP:0012439)2.03438583
111Ketosis (HP:0001946)2.03014311
112Progressive macrocephaly (HP:0004481)2.02882193
113Abnormality of the dental pulp (HP:0006479)2.02879055
114Rhinitis (HP:0012384)2.01517443
115Renal tubular dysfunction (HP:0000124)2.00872470
116Sclerocornea (HP:0000647)2.00438238
117Pancreatic fibrosis (HP:0100732)1.99697120
118Generalized hypopigmentation of hair (HP:0011358)1.99261193
119Increased serum lactate (HP:0002151)1.97234980
120Potter facies (HP:0002009)1.95631775
121Facial shape deformation (HP:0011334)1.95631775
122Optic nerve hypoplasia (HP:0000609)1.94323493
123Abnormality of permanent molar morphology (HP:0011071)1.93593144
124Abnormality of the dental root (HP:0006486)1.93593144
125Taurodontia (HP:0000679)1.93593144
126Nephronophthisis (HP:0000090)1.92573309
127Nuclear cataract (HP:0100018)1.92494611
128Dysdiadochokinesis (HP:0002075)1.92235212
129Lipid accumulation in hepatocytes (HP:0006561)1.90854770
130Symptomatic seizures (HP:0011145)1.90094358
131Male pseudohermaphroditism (HP:0000037)1.89333670
132Azoospermia (HP:0000027)1.88177282
133Abnormality of vitamin metabolism (HP:0100508)1.87696884
134Thyroiditis (HP:0100646)1.87320948
135Inability to walk (HP:0002540)1.86795115
136Abnormality of molar (HP:0011077)1.86508658
137Abnormality of molar morphology (HP:0011070)1.86508658
138Lactic acidosis (HP:0003128)1.85226307
139Cerebellar dysplasia (HP:0007033)1.85063447
140Exertional dyspnea (HP:0002875)1.84931586
141Parakeratosis (HP:0001036)1.83712119
142Short tibia (HP:0005736)1.82958750
143Abnormal mitochondria in muscle tissue (HP:0008316)1.82426872
144Acute necrotizing encephalopathy (HP:0006965)1.81332184
145Severe muscular hypotonia (HP:0006829)1.80785031
146Hypoplasia of the fovea (HP:0007750)1.80630876
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.80630876
148Lissencephaly (HP:0001339)1.78798197
149Hypoglycemic seizures (HP:0002173)1.77571155
150Chorioretinal atrophy (HP:0000533)1.77398801
151True hermaphroditism (HP:0010459)1.77117358
152Abnormal urine output (HP:0012590)1.76648868
153Specific learning disability (HP:0001328)1.76136538
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75997741
155Hypoplasia of the uterus (HP:0000013)1.75985337
156Increased intramyocellular lipid droplets (HP:0012240)1.75927530
157Tubulointerstitial nephritis (HP:0001970)1.75776914
158Stomach cancer (HP:0012126)1.75626192
159Truncal ataxia (HP:0002078)1.75376927
160Decreased circulating renin level (HP:0003351)1.71805682
161Cerebral edema (HP:0002181)1.70693657
162Progressive inability to walk (HP:0002505)1.69958762
163Lethargy (HP:0001254)1.69779601
164Epileptiform EEG discharges (HP:0011182)1.69759428
165Postaxial foot polydactyly (HP:0001830)1.69276237
166Absent speech (HP:0001344)1.67396240
167Increased circulating renin level (HP:0000848)1.67263043
168Scanning speech (HP:0002168)1.67186958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.58524502
2MKNK25.53623444
3MAP4K24.03883337
4MAP2K73.64854714
5BMPR1B3.52959161
6INSRR3.50711943
7TLK13.31454324
8CASK3.29366873
9MKNK12.84071046
10NUAK12.17767257
11MAP3K122.15227940
12ADRBK22.13988096
13MAP3K42.06975590
14WNK41.97022271
15NTRK31.95451036
16TAOK31.88553497
17PDK31.88272914
18PDK41.88272914
19ACVR1B1.82401283
20MST41.73903871
21RIPK11.65446694
22EPHA41.63939668
23BCKDK1.63749550
24PHKG21.62254442
25PHKG11.62254442
26TNK21.62243179
27PRKCG1.57876380
28PLK21.56894840
29OXSR11.54608351
30MAPK131.51513546
31PIK3CG1.50735833
32GRK71.47787106
33RIPK41.47171827
34MUSK1.45156557
35MAP2K61.44996156
36MAPKAPK31.43402495
37TGFBR11.39274222
38BMPR21.36699579
39FRK1.36673546
40TSSK61.33989594
41NTRK11.31042160
42TXK1.30962187
43PRKD31.30527530
44PDK21.30242605
45STK391.22205109
46PRKCE1.20430859
47CAMK1G1.20223047
48SGK21.18592177
49CAMKK21.11877936
50STK161.09302935
51CAMK1D1.09187886
52MINK11.08424991
53WNK31.07890781
54CDK81.07367138
55MAP2K41.06817144
56CCNB11.06604201
57MAP3K21.03353229
58NTRK21.01946482
59VRK11.01295122
60CSNK1G11.00046556
61CSNK1G30.99268851
62SGK2230.98129055
63SGK4940.98129055
64CSNK1G20.97472799
65MYLK0.97450313
66OBSCN0.96317155
67MAPK120.93486540
68FGFR20.92825264
69PTK2B0.89520241
70CAMK2A0.86997835
71PAK30.85008639
72MAP3K140.84844095
73AKT30.84532298
74GRK50.81653752
75PRPF4B0.81023043
76KIT0.79514027
77BRSK20.73777202
78NEK60.72180296
79IKBKB0.72086209
80ERBB30.69667944
81TRPM70.69579451
82VRK20.68585088
83STK30.67734467
84SGK10.66814293
85TIE10.66605600
86TEC0.65894776
87PLK40.65182046
88CSNK1A1L0.65175807
89EIF2AK30.64923464
90FER0.64798989
91FLT30.64496255
92PLK30.63861909
93CAMK2D0.62996641
94SGK30.61269943
95MAP2K10.61146538
96PRKCI0.60475683
97BCR0.60318305
98FES0.60137378
99STK38L0.59692515
100MAPK70.58627171
101MARK10.58622634
102PRKCQ0.58295948
103TAOK20.58222904
104SIK30.57856066
105CDK50.57272857
106PIK3CA0.55570680
107ERBB40.54093292
108TRIM280.52232456
109MAPKAPK50.51515025
110LMTK20.51330823
111PRKCH0.50898925
112SIK20.49123986
113PRKACA0.46406935
114PNCK0.46257692
115ITK0.46165270
116ZAK0.45573140
117RPS6KB10.45299155
118CHUK0.43230549
119PRKACB0.43229449
120RPS6KA50.42704872
121MAP3K10.42351034
122CAMK10.41762148
123IRAK10.41613342
124PRKCA0.41415956
125DYRK1A0.41196406
126EPHA30.41062217
127CDK30.40974721
128GRK10.40416658
129DYRK20.39002420
130CAMK2G0.38992859
131CAMK2B0.38700649
132IGF1R0.38695675
133MAPK40.34555631
134PAK60.34362188
135PKN10.34101311
136PRKAA10.32132637
137ADRBK10.31930277
138MAP2K20.31575589
139PRKCZ0.31075139
140DAPK10.30710174
141UHMK10.30217336
142PRKCB0.30128668
143WEE10.29663870
144PRKAA20.29263620
145DAPK20.28923830
146SYK0.28521544
147GRK60.28301215
148CSNK1D0.28278185
149PLK10.27826395
150MAPK100.27473230
151ABL10.26093913
152ROCK20.25870956
153CSNK1A10.25825580
154PINK10.24877651
155PRKG10.24136047
156STK380.23987020
157MATK0.23200461

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81832148
2Synaptic vesicle cycle_Homo sapiens_hsa047212.83784263
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.83551671
4GABAergic synapse_Homo sapiens_hsa047272.72163855
5Nitrogen metabolism_Homo sapiens_hsa009102.62342716
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57616444
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52416554
8Collecting duct acid secretion_Homo sapiens_hsa049662.52359743
9Morphine addiction_Homo sapiens_hsa050322.51399773
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.50245677
11Protein export_Homo sapiens_hsa030602.49482285
12Taste transduction_Homo sapiens_hsa047422.47416695
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32833263
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09459141
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00450765
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95762893
17Circadian entrainment_Homo sapiens_hsa047131.94791006
18Insulin secretion_Homo sapiens_hsa049111.91007137
19Tryptophan metabolism_Homo sapiens_hsa003801.90987404
20Fatty acid biosynthesis_Homo sapiens_hsa000611.90155140
21Glutamatergic synapse_Homo sapiens_hsa047241.83820876
22Selenocompound metabolism_Homo sapiens_hsa004501.82365629
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82214672
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79633657
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78521304
26Butanoate metabolism_Homo sapiens_hsa006501.73671032
27Oxidative phosphorylation_Homo sapiens_hsa001901.72227649
28Salivary secretion_Homo sapiens_hsa049701.71236995
29Homologous recombination_Homo sapiens_hsa034401.69246821
30Asthma_Homo sapiens_hsa053101.65660579
31Serotonergic synapse_Homo sapiens_hsa047261.64625265
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.63422804
33Caffeine metabolism_Homo sapiens_hsa002321.58187537
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48056010
35RNA polymerase_Homo sapiens_hsa030201.46985104
36Vibrio cholerae infection_Homo sapiens_hsa051101.43055164
37Basal transcription factors_Homo sapiens_hsa030221.41110810
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34024822
39RNA degradation_Homo sapiens_hsa030181.31334442
40Steroid biosynthesis_Homo sapiens_hsa001001.30964431
41Peroxisome_Homo sapiens_hsa041461.30647196
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29417561
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29270772
44Gastric acid secretion_Homo sapiens_hsa049711.29210114
45Renin secretion_Homo sapiens_hsa049241.27433413
46Cardiac muscle contraction_Homo sapiens_hsa042601.26887212
47Cholinergic synapse_Homo sapiens_hsa047251.25757007
48Proteasome_Homo sapiens_hsa030501.25273865
49Allograft rejection_Homo sapiens_hsa053301.23149591
50Graft-versus-host disease_Homo sapiens_hsa053321.21881900
51Calcium signaling pathway_Homo sapiens_hsa040201.20306567
52Alzheimers disease_Homo sapiens_hsa050101.20194475
53Autoimmune thyroid disease_Homo sapiens_hsa053201.19638405
54Amphetamine addiction_Homo sapiens_hsa050311.19150106
55Fanconi anemia pathway_Homo sapiens_hsa034601.16714832
56Olfactory transduction_Homo sapiens_hsa047401.15592444
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10698063
58Dopaminergic synapse_Homo sapiens_hsa047281.10634582
59Fatty acid metabolism_Homo sapiens_hsa012121.08792425
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04634097
61ABC transporters_Homo sapiens_hsa020101.03570036
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.03421187
63Regulation of autophagy_Homo sapiens_hsa041401.03254211
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02389119
65Long-term potentiation_Homo sapiens_hsa047200.97704999
66Mineral absorption_Homo sapiens_hsa049780.95029051
67cAMP signaling pathway_Homo sapiens_hsa040240.89762849
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89485618
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88829965
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88410409
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.85876380
72Parkinsons disease_Homo sapiens_hsa050120.85589392
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84693362
74One carbon pool by folate_Homo sapiens_hsa006700.84237127
75Type II diabetes mellitus_Homo sapiens_hsa049300.83636347
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83386812
77Cocaine addiction_Homo sapiens_hsa050300.82702232
78Rheumatoid arthritis_Homo sapiens_hsa053230.81419073
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.80245417
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80172727
81beta-Alanine metabolism_Homo sapiens_hsa004100.79532242
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77260401
83Propanoate metabolism_Homo sapiens_hsa006400.77072931
84Ether lipid metabolism_Homo sapiens_hsa005650.76750123
85Purine metabolism_Homo sapiens_hsa002300.75446465
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.74892671
87Bile secretion_Homo sapiens_hsa049760.74205547
88Type I diabetes mellitus_Homo sapiens_hsa049400.73455388
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73381972
90Phototransduction_Homo sapiens_hsa047440.72889857
91Starch and sucrose metabolism_Homo sapiens_hsa005000.72737130
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72033844
93Thyroid hormone synthesis_Homo sapiens_hsa049180.71274176
94Pancreatic secretion_Homo sapiens_hsa049720.71195426
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70906639
96Long-term depression_Homo sapiens_hsa047300.70085933
97Huntingtons disease_Homo sapiens_hsa050160.69436798
98Ovarian steroidogenesis_Homo sapiens_hsa049130.68870351
99Chemical carcinogenesis_Homo sapiens_hsa052040.67725017
100Fatty acid elongation_Homo sapiens_hsa000620.67153367
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66449690
102Metabolic pathways_Homo sapiens_hsa011000.65899294
103Dilated cardiomyopathy_Homo sapiens_hsa054140.63835012
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62161506
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62075580
106Oxytocin signaling pathway_Homo sapiens_hsa049210.61169212
107Fructose and mannose metabolism_Homo sapiens_hsa000510.60484694
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58297293
109Non-homologous end-joining_Homo sapiens_hsa034500.58102235
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57831931
111Sulfur metabolism_Homo sapiens_hsa009200.56134941
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56055317
113Fat digestion and absorption_Homo sapiens_hsa049750.55826348
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55533306
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.55338328
116Linoleic acid metabolism_Homo sapiens_hsa005910.54618798
117Glycerolipid metabolism_Homo sapiens_hsa005610.53658343
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53199420
119Primary immunodeficiency_Homo sapiens_hsa053400.52728169
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51721917
121Phagosome_Homo sapiens_hsa041450.51693708
122Fatty acid degradation_Homo sapiens_hsa000710.51671510
123Estrogen signaling pathway_Homo sapiens_hsa049150.49803391
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49078698
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49012183
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48675491
127Pyruvate metabolism_Homo sapiens_hsa006200.48454693
128Antigen processing and presentation_Homo sapiens_hsa046120.48141468
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48106202
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46626081
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46250838
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45694682
133Folate biosynthesis_Homo sapiens_hsa007900.45432669
134Sulfur relay system_Homo sapiens_hsa041220.44627515
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44532205
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42224872
137Circadian rhythm_Homo sapiens_hsa047100.41411721
138Retinol metabolism_Homo sapiens_hsa008300.41144271
139Axon guidance_Homo sapiens_hsa043600.37851898
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.37808044
141Histidine metabolism_Homo sapiens_hsa003400.36991638
142Ras signaling pathway_Homo sapiens_hsa040140.36382952
143Nucleotide excision repair_Homo sapiens_hsa034200.35333869
144Glucagon signaling pathway_Homo sapiens_hsa049220.34238567
145Inositol phosphate metabolism_Homo sapiens_hsa005620.33291600
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32351233
147Arachidonic acid metabolism_Homo sapiens_hsa005900.32204359
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31910984

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