ZDBF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.90262481
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.77409212
3presynaptic membrane assembly (GO:0097105)3.74791255
4negative regulation of cytosolic calcium ion concentration (GO:0051481)3.51743477
5layer formation in cerebral cortex (GO:0021819)3.49604001
6regulation of gene silencing by RNA (GO:0060966)3.39114255
7regulation of posttranscriptional gene silencing (GO:0060147)3.39114255
8regulation of gene silencing by miRNA (GO:0060964)3.39114255
9presynaptic membrane organization (GO:0097090)3.26019451
10pyrimidine nucleobase catabolic process (GO:0006208)3.22252896
11nuclear pore complex assembly (GO:0051292)3.18769304
12dendritic spine morphogenesis (GO:0060997)3.17996989
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15082750
14nuclear pore organization (GO:0006999)3.12534665
15axonal fasciculation (GO:0007413)3.03916126
16genetic imprinting (GO:0071514)3.03465453
17histone H4-K12 acetylation (GO:0043983)3.00397046
18neuron recognition (GO:0008038)2.98216794
19protein localization to synapse (GO:0035418)2.97841732
20neuron cell-cell adhesion (GO:0007158)2.95817883
21negative regulation of organelle assembly (GO:1902116)2.94624203
22establishment of nucleus localization (GO:0040023)2.89382389
23synaptic vesicle docking involved in exocytosis (GO:0016081)2.78604899
24positive regulation of dendritic spine morphogenesis (GO:0061003)2.78370952
25nucleobase catabolic process (GO:0046113)2.78090423
26atrial cardiac muscle cell action potential (GO:0086014)2.76177662
27stress granule assembly (GO:0034063)2.73744912
28proline transport (GO:0015824)2.73573268
29DNA strand renaturation (GO:0000733)2.71863730
30synaptic vesicle maturation (GO:0016188)2.69893774
31positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66472567
32cell migration in hindbrain (GO:0021535)2.65114964
33establishment of monopolar cell polarity (GO:0061162)2.64995559
34establishment or maintenance of monopolar cell polarity (GO:0061339)2.64995559
35paraxial mesoderm development (GO:0048339)2.64209574
36synaptic vesicle exocytosis (GO:0016079)2.63078808
37spliceosomal tri-snRNP complex assembly (GO:0000244)2.61728394
38embryonic foregut morphogenesis (GO:0048617)2.61703020
39cerebellar Purkinje cell differentiation (GO:0021702)2.60476441
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60058760
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59794026
42inner ear receptor cell development (GO:0060119)2.58753271
43negative regulation of histone methylation (GO:0031061)2.57671316
44cerebral cortex radially oriented cell migration (GO:0021799)2.57028540
45nucleus localization (GO:0051647)2.56828489
46regulation of synaptic vesicle exocytosis (GO:2000300)2.55919386
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.54699638
48mitochondrion transport along microtubule (GO:0047497)2.54699638
49regulation of cAMP-dependent protein kinase activity (GO:2000479)2.53416035
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52159881
51gastrulation with mouth forming second (GO:0001702)2.51866724
52negative regulation of neurotransmitter secretion (GO:0046929)2.51077298
53head development (GO:0060322)2.50477143
54locomotory exploration behavior (GO:0035641)2.48913309
55central nervous system neuron axonogenesis (GO:0021955)2.47921206
56vocalization behavior (GO:0071625)2.47605815
57peptidyl-arginine omega-N-methylation (GO:0035247)2.46087716
58regulation of glutamate receptor signaling pathway (GO:1900449)2.46051434
59intra-S DNA damage checkpoint (GO:0031573)2.45370445
60cerebellum development (GO:0021549)2.43926348
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.43329948
62regulation of translation, ncRNA-mediated (GO:0045974)2.43329948
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43329948
64histone arginine methylation (GO:0034969)2.42083501
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41652942
66peptidyl-arginine N-methylation (GO:0035246)2.41594935
67peptidyl-arginine methylation (GO:0018216)2.41594935
68exploration behavior (GO:0035640)2.41371647
69cerebral cortex development (GO:0021987)2.41300498
70body morphogenesis (GO:0010171)2.40771511
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.39124992
72establishment of apical/basal cell polarity (GO:0035089)2.39113628
73regulation of growth hormone secretion (GO:0060123)2.38449451
74neuron fate determination (GO:0048664)2.38434917
75neuronal action potential propagation (GO:0019227)2.38323705
76regulation of synaptic vesicle transport (GO:1902803)2.37911964
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.37416460
78mitotic sister chromatid cohesion (GO:0007064)2.37054373
79histone H4-K8 acetylation (GO:0043982)2.36974259
80histone H4-K5 acetylation (GO:0043981)2.36974259
81regulation of telomere maintenance via telomerase (GO:0032210)2.36603349
82innervation (GO:0060384)2.35990912
83mRNA splice site selection (GO:0006376)2.35473735
84cytoplasmic mRNA processing body assembly (GO:0033962)2.33070015
85regulation of microtubule-based movement (GO:0060632)2.32906675
86establishment of protein localization to Golgi (GO:0072600)2.31389612
87glutamate receptor signaling pathway (GO:0007215)2.31278292
88glutamate secretion (GO:0014047)2.30474333
89negative regulation of neurotransmitter transport (GO:0051589)2.29782268
90postsynaptic membrane organization (GO:0001941)2.29746043
91regulation of RNA export from nucleus (GO:0046831)2.29074713
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.29034145
93positive regulation of cellular response to oxidative stress (GO:1900409)2.26775632
94positive regulation of response to oxidative stress (GO:1902884)2.26775632
95neurotransmitter secretion (GO:0007269)2.26660674
96ncRNA catabolic process (GO:0034661)2.25096596
97anterior/posterior axis specification, embryo (GO:0008595)2.24883140
98cerebellar Purkinje cell layer development (GO:0021680)2.24361099
99regulation of telomere maintenance (GO:0032204)2.23532629
100polarized epithelial cell differentiation (GO:0030859)2.23431996
101auditory behavior (GO:0031223)2.23083814
102intraciliary transport (GO:0042073)2.23044922
103establishment of planar polarity (GO:0001736)2.22893821
104establishment of tissue polarity (GO:0007164)2.22893821
105respiratory system process (GO:0003016)2.22779155
106regulation of NFAT protein import into nucleus (GO:0051532)2.22739884
107negative regulation of hormone biosynthetic process (GO:0032353)2.22016540
108dorsal/ventral axis specification (GO:0009950)2.21567557
109microtubule depolymerization (GO:0007019)2.21500615
110DNA replication-dependent nucleosome assembly (GO:0006335)2.20950618
111DNA replication-dependent nucleosome organization (GO:0034723)2.20950618
112establishment of mitochondrion localization (GO:0051654)2.20633898
113response to pheromone (GO:0019236)2.20249943
114organelle transport along microtubule (GO:0072384)2.20148844
115ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.20047388
116central nervous system projection neuron axonogenesis (GO:0021952)2.20046706
117protein targeting to Golgi (GO:0000042)2.20028010
118positive regulation of synapse assembly (GO:0051965)2.19920807
119appendage development (GO:0048736)2.19736435
120limb development (GO:0060173)2.19736435
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.19564929
122regulation of calcium ion-dependent exocytosis (GO:0017158)2.19109939
123suckling behavior (GO:0001967)2.19028988
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.18924066
125prenylation (GO:0097354)2.18705560
126protein prenylation (GO:0018342)2.18705560
127negative regulation of DNA repair (GO:0045738)2.17644694
128retinal ganglion cell axon guidance (GO:0031290)2.16997880
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.16938282
130vesicle transport along microtubule (GO:0047496)2.16345745
131microtubule anchoring (GO:0034453)2.15899313
132neurotransmitter-gated ion channel clustering (GO:0072578)2.15851970
133glucocorticoid receptor signaling pathway (GO:0042921)2.15299659
134regulation of respiratory system process (GO:0044065)2.15190681
135protein K11-linked deubiquitination (GO:0035871)2.15136782
136somite rostral/caudal axis specification (GO:0032525)2.13521392
137positive regulation of synapse maturation (GO:0090129)2.13460103
138myotube differentiation (GO:0014902)2.13091737
139dendrite morphogenesis (GO:0048813)2.12884456
140interkinetic nuclear migration (GO:0022027)2.12875306
141neuron-neuron synaptic transmission (GO:0007270)2.12717098
142genitalia morphogenesis (GO:0035112)2.12266035
143membrane depolarization during action potential (GO:0086010)2.11920944
144regulation of Rac protein signal transduction (GO:0035020)2.11683715
145axon extension (GO:0048675)2.11370271
146transmission of nerve impulse (GO:0019226)2.11193102
147startle response (GO:0001964)2.11008743
148chemosensory behavior (GO:0007635)2.10599104
149forebrain neuron differentiation (GO:0021879)2.10240209
150synaptic vesicle endocytosis (GO:0048488)2.10223587
151neural tube formation (GO:0001841)2.10190290
152calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.10091935
153artery development (GO:0060840)2.09852567
154olfactory bulb development (GO:0021772)2.09757681
155positive regulation of cardiac muscle cell differentiation (GO:2000727)2.08823060
156negative regulation of dendrite development (GO:2000171)2.07207247
157righting reflex (GO:0060013)2.06992297
158synaptic transmission, glutamatergic (GO:0035249)2.06910080
159insulin secretion (GO:0030073)2.06788008
160lung-associated mesenchyme development (GO:0060484)2.06169840
161retrograde transport, vesicle recycling within Golgi (GO:0000301)2.06029412
162regulation of transforming growth factor beta2 production (GO:0032909)2.05668185
163monoubiquitinated protein deubiquitination (GO:0035520)2.05596339
164hippocampus development (GO:0021766)2.04321957
165Golgi to endosome transport (GO:0006895)2.03633118
166nonmotile primary cilium assembly (GO:0035058)2.03397096
167synapse assembly (GO:0007416)2.02632217
168detection of calcium ion (GO:0005513)2.01049867
169regulation of DNA endoreduplication (GO:0032875)2.00779548
170regulation of cell communication by electrical coupling (GO:0010649)2.00317391
171behavioral defense response (GO:0002209)1.99261941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91575536
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.38829712
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84871088
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.82705656
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61962204
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44180688
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39483106
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37861154
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34009458
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19579566
11REST_21632747_ChIP-Seq_MESCs_Mouse2.05257237
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05049045
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05033470
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01215987
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01074724
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95806920
17GBX2_23144817_ChIP-Seq_PC3_Human1.95644757
18EWS_26573619_Chip-Seq_HEK293_Human1.94245124
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91075501
20ZNF274_21170338_ChIP-Seq_K562_Hela1.88123898
21MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82789411
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.82280309
23E2F7_22180533_ChIP-Seq_HELA_Human1.81617324
24FUS_26573619_Chip-Seq_HEK293_Human1.79132052
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.78996029
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77397867
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76850986
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74442202
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67893496
30* FLI1_27457419_Chip-Seq_LIVER_Mouse1.62863294
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62361715
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62287429
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61463613
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.60073474
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56972815
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.56642597
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56347610
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56122853
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55687194
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.55372348
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53940853
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49207483
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48871220
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.48573615
45IGF1R_20145208_ChIP-Seq_DFB_Human1.48419534
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46860366
47* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45396811
48* TCF4_23295773_ChIP-Seq_U87_Human1.44550971
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44436103
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43792529
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41724565
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41724565
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41724565
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40057946
55* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39961199
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.39125377
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.36001337
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35627320
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35011075
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33279821
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32001241
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31903270
63AR_25329375_ChIP-Seq_VCAP_Human1.31641281
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31532801
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29678363
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28977233
67* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28163415
68CBP_20019798_ChIP-Seq_JUKART_Human1.28160185
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28160185
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27452645
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27133449
72AR_21572438_ChIP-Seq_LNCaP_Human1.25914722
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25468503
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24011730
75* EZH2_27294783_Chip-Seq_NPCs_Mouse1.23873294
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21981773
77RUNX2_22187159_ChIP-Seq_PCA_Human1.19877396
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19355478
79VDR_22108803_ChIP-Seq_LS180_Human1.19326210
80* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19260476
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18954909
82POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.18770342
83* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18704327
84* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18142282
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18112749
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17583627
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17469813
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17242202
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.16017632
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15659926
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15062101
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15062054
93* E2F1_18555785_Chip-Seq_ESCs_Mouse1.14938629
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13984901
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.13131839
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13074814
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12880701
98TAF15_26573619_Chip-Seq_HEK293_Human1.12458979
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12187093
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12071404
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11615472
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10859417
103SMAD4_21799915_ChIP-Seq_A2780_Human1.10398481
104ER_23166858_ChIP-Seq_MCF-7_Human1.09673528
105E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09572803
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09114982
107* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08696583
108* STAT3_23295773_ChIP-Seq_U87_Human1.08655861
109POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08629900
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.08454823
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08185618
112* P53_22387025_ChIP-Seq_ESCs_Mouse1.07872835
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07501380
114TP53_16413492_ChIP-PET_HCT116_Human1.07203589
115TP53_18474530_ChIP-ChIP_U2OS_Human1.07183005
116P300_19829295_ChIP-Seq_ESCs_Human1.06980453
117* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06462042
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06407412
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06407412
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05967741
121* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04978767
122JUN_21703547_ChIP-Seq_K562_Human1.04826889
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04762677
124JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04510413
125BCAT_22108803_ChIP-Seq_LS180_Human1.04282287
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03980354
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03829984
128SOX2_16153702_ChIP-ChIP_HESCs_Human1.03154731
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.02829412
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.02658894
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.02651095
132TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01982801
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01220051
134* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01026290
135NANOG_21062744_ChIP-ChIP_HESCs_Human1.00862954
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00632841
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99854680
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99650783
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.98456997
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98352501
141* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.98023438
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.97744374
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97000478
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96723315
145* RNF2_27304074_Chip-Seq_ESCs_Mouse0.96686943
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95558377
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95476308
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95346352
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95346352
150SOX9_26525672_Chip-Seq_HEART_Mouse0.95039285
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.94901921
152AR_19668381_ChIP-Seq_PC3_Human0.94522403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.15153441
2MP0003121_genomic_imprinting3.69739493
3MP0003123_paternal_imprinting3.46737218
4MP0003787_abnormal_imprinting2.38071377
5MP0003890_abnormal_embryonic-extraembry2.34254746
6MP0005645_abnormal_hypothalamus_physiol2.31966074
7MP0004270_analgesia2.27092458
8MP0003283_abnormal_digestive_organ2.25654324
9MP0004859_abnormal_synaptic_plasticity2.21042048
10MP0003880_abnormal_central_pattern2.10966428
11MP0002822_catalepsy2.03422276
12MP0003119_abnormal_digestive_system1.90061854
13MP0003635_abnormal_synaptic_transmissio1.85968092
14MP0005423_abnormal_somatic_nervous1.82226803
15MP0002102_abnormal_ear_morphology1.80679492
16MP0000778_abnormal_nervous_system1.77651999
17MP0001529_abnormal_vocalization1.74638950
18MP0006072_abnormal_retinal_apoptosis1.73502160
19MP0006276_abnormal_autonomic_nervous1.72373969
20MP0001984_abnormal_olfaction1.68011174
21MP0002653_abnormal_ependyma_morphology1.66544014
22MP0006292_abnormal_olfactory_placode1.65311790
23MP0002009_preneoplasia1.63107304
24MP0008877_abnormal_DNA_methylation1.61065918
25MP0002063_abnormal_learning/memory/cond1.58312904
26MP0004133_heterotaxia1.55918775
27MP0008057_abnormal_DNA_replication1.42741827
28MP0002734_abnormal_mechanical_nocicepti1.42271800
29MP0000631_abnormal_neuroendocrine_gland1.42236384
30MP0002572_abnormal_emotion/affect_behav1.40274569
31MP0002184_abnormal_innervation1.40108161
32MP0002909_abnormal_adrenal_gland1.39387163
33MP0002557_abnormal_social/conspecific_i1.36074400
34MP0004233_abnormal_muscle_weight1.34471341
35MP0000566_synostosis1.33064119
36MP0009046_muscle_twitch1.32282648
37MP0003861_abnormal_nervous_system1.31338427
38MP0009745_abnormal_behavioral_response1.30950581
39MP0002084_abnormal_developmental_patter1.26821141
40MP0005076_abnormal_cell_differentiation1.26307675
41MP0000955_abnormal_spinal_cord1.24832021
42MP0005646_abnormal_pituitary_gland1.23278651
43MP0002697_abnormal_eye_size1.20149425
44MP0002152_abnormal_brain_morphology1.15476872
45MP0000537_abnormal_urethra_morphology1.14752316
46MP0001188_hyperpigmentation1.13539682
47MP0004811_abnormal_neuron_physiology1.13119724
48MP0000013_abnormal_adipose_tissue1.12544249
49MP0001486_abnormal_startle_reflex1.12413088
50MP0009780_abnormal_chondrocyte_physiolo1.12090506
51MP0002064_seizures1.10982814
52MP0002638_abnormal_pupillary_reflex1.10555146
53MP0010030_abnormal_orbit_morphology1.10484344
54MP0008961_abnormal_basal_metabolism1.10421146
55MP0004142_abnormal_muscle_tone1.07918123
56MP0003385_abnormal_body_wall1.07811078
57MP0002733_abnormal_thermal_nociception1.07335199
58MP0001968_abnormal_touch/_nociception1.07257755
59MP0003111_abnormal_nucleus_morphology1.07241543
60MP0001346_abnormal_lacrimal_gland1.06589151
61MP0002938_white_spotting1.05278940
62MP0001293_anophthalmia1.04968683
63MP0004197_abnormal_fetal_growth/weight/1.04200011
64MP0005187_abnormal_penis_morphology1.04125109
65MP0002751_abnormal_autonomic_nervous1.03049623
66MP0002085_abnormal_embryonic_tissue1.02636636
67MP0009703_decreased_birth_body1.01976057
68MP0008995_early_reproductive_senescence1.01435308
69MP0002882_abnormal_neuron_morphology1.01042489
70MP0004145_abnormal_muscle_electrophysio1.00688104
71MP0002234_abnormal_pharynx_morphology1.00576558
72MP0003136_yellow_coat_color0.99825712
73MP0004215_abnormal_myocardial_fiber0.98461876
74MP0001299_abnormal_eye_distance/0.97701012
75MP0005551_abnormal_eye_electrophysiolog0.97427765
76MP0009672_abnormal_birth_weight0.97035344
77MP0004264_abnormal_extraembryonic_tissu0.96710622
78MP0004924_abnormal_behavior0.95812446
79MP0005386_behavior/neurological_phenoty0.95812446
80MP0002272_abnormal_nervous_system0.95787824
81MP0005391_vision/eye_phenotype0.94537918
82MP0003937_abnormal_limbs/digits/tail_de0.94236873
83MP0010386_abnormal_urinary_bladder0.93183016
84MP0001502_abnormal_circadian_rhythm0.91862396
85MP0003942_abnormal_urinary_system0.91762013
86MP0003698_abnormal_male_reproductive0.91422519
87MP0005248_abnormal_Harderian_gland0.91392894
88MP0008058_abnormal_DNA_repair0.90643086
89MP0000647_abnormal_sebaceous_gland0.90253270
90MP0004957_abnormal_blastocyst_morpholog0.90178648
91MP0003941_abnormal_skin_development0.89096569
92MP0002735_abnormal_chemical_nociception0.89040280
93MP0001286_abnormal_eye_development0.88603848
94MP0001177_atelectasis0.88035116
95MP0002233_abnormal_nose_morphology0.87355110
96MP0002081_perinatal_lethality0.87320928
97MP0003567_abnormal_fetal_cardiomyocyte0.86369191
98MP0003755_abnormal_palate_morphology0.85943974
99MP0005394_taste/olfaction_phenotype0.85608481
100MP0005499_abnormal_olfactory_system0.85608481
101MP0004885_abnormal_endolymph0.84690103
102MP0000569_abnormal_digit_pigmentation0.84621712
103MP0005623_abnormal_meninges_morphology0.84569166
104MP0001730_embryonic_growth_arrest0.84479793
105MP0001501_abnormal_sleep_pattern0.84419769
106MP0002116_abnormal_craniofacial_bone0.84416817
107MP0002752_abnormal_somatic_nervous0.84300201
108MP0000534_abnormal_ureter_morphology0.84191219
109MP0002067_abnormal_sensory_capabilities0.83966450
110MP0005253_abnormal_eye_physiology0.82728580
111MP0000462_abnormal_digestive_system0.82616544
112MP0000639_abnormal_adrenal_gland0.82339306
113MP0001849_ear_inflammation0.81629728
114MP0001485_abnormal_pinna_reflex0.80706259
115MP0010094_abnormal_chromosome_stability0.80188824
116MP0005380_embryogenesis_phenotype0.80158895
117MP0001672_abnormal_embryogenesis/_devel0.80158895
118MP0003935_abnormal_craniofacial_develop0.79906669
119MP0009697_abnormal_copulation0.78758470
120MP0000049_abnormal_middle_ear0.78755019
121MP0003959_abnormal_lean_body0.77951365
122MP0002160_abnormal_reproductive_system0.77468158
123MP0000428_abnormal_craniofacial_morphol0.76793429
124MP0005367_renal/urinary_system_phenotyp0.76474775
125MP0000516_abnormal_urinary_system0.76474775
126MP0002066_abnormal_motor_capabilities/c0.76014437

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.75314849
2Febrile seizures (HP:0002373)2.88084574
3Hepatoblastoma (HP:0002884)2.84569399
4Missing ribs (HP:0000921)2.71146964
5Abnormality of the astrocytes (HP:0100707)2.71107280
6Astrocytoma (HP:0009592)2.71107280
7Ependymoma (HP:0002888)2.65468404
8Failure to thrive in infancy (HP:0001531)2.62768849
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59187491
10Cutaneous finger syndactyly (HP:0010554)2.49102263
11Pheochromocytoma (HP:0002666)2.48370178
12Shoulder girdle muscle weakness (HP:0003547)2.39999257
13Papillary thyroid carcinoma (HP:0002895)2.38484861
14Neoplasm of the heart (HP:0100544)2.33343586
15Medulloblastoma (HP:0002885)2.32043816
16Hyperventilation (HP:0002883)2.31186679
17Glioma (HP:0009733)2.29860384
18Broad-based gait (HP:0002136)2.29570802
19Aqueductal stenosis (HP:0002410)2.27121150
20Chronic hepatic failure (HP:0100626)2.26150039
21Abnormality of the ischium (HP:0003174)2.20141419
22Genital tract atresia (HP:0001827)2.18001038
23Neoplasm of the oral cavity (HP:0100649)2.16895111
24Dialeptic seizures (HP:0011146)2.14874546
25Agitation (HP:0000713)2.14017222
26Shawl scrotum (HP:0000049)2.13371521
27Vaginal atresia (HP:0000148)2.12429998
28Facial cleft (HP:0002006)2.10957382
29Neuroendocrine neoplasm (HP:0100634)2.08823475
30Macroorchidism (HP:0000053)2.08147937
31Gaze-evoked nystagmus (HP:0000640)2.07273472
32Bifid tongue (HP:0010297)2.05377755
3311 pairs of ribs (HP:0000878)2.02837911
34Thyroid carcinoma (HP:0002890)2.02360963
35Gait imbalance (HP:0002141)2.01818760
36Oligodactyly (hands) (HP:0001180)2.00397087
37Drooling (HP:0002307)2.00167287
38Excessive salivation (HP:0003781)2.00167287
39Visual hallucinations (HP:0002367)1.99910565
40Gastrointestinal atresia (HP:0002589)1.98651738
41Labial hypoplasia (HP:0000066)1.98451337
42Poor coordination (HP:0002370)1.97829324
43Atonic seizures (HP:0010819)1.96625691
44Limb dystonia (HP:0002451)1.96537445
45Amyotrophic lateral sclerosis (HP:0007354)1.95764975
46Abnormality of the lower motor neuron (HP:0002366)1.94165527
47Volvulus (HP:0002580)1.93383165
48Preaxial foot polydactyly (HP:0001841)1.93279842
49Aplasia/Hypoplasia of the tibia (HP:0005772)1.92278653
50Focal seizures (HP:0007359)1.88414060
51Dynein arm defect of respiratory motile cilia (HP:0012255)1.87664148
52Absent/shortened dynein arms (HP:0200106)1.87664148
53Hyperinsulinemic hypoglycemia (HP:0000825)1.86728170
54Overlapping toe (HP:0001845)1.86288390
55Double outlet right ventricle (HP:0001719)1.85825457
56Congenital malformation of the right heart (HP:0011723)1.85825457
57Progressive cerebellar ataxia (HP:0002073)1.85321868
58Epileptic encephalopathy (HP:0200134)1.85109448
59Colon cancer (HP:0003003)1.84731047
60Nephrogenic diabetes insipidus (HP:0009806)1.82740865
61Renal duplication (HP:0000075)1.82162973
62Supernumerary spleens (HP:0009799)1.81819070
63Short humerus (HP:0005792)1.81439781
64Menstrual irregularities (HP:0000858)1.80079748
65Abdominal situs inversus (HP:0003363)1.79712808
66Abnormality of abdominal situs (HP:0011620)1.79712808
67Abnormal pancreas size (HP:0012094)1.78049855
68Pelvic girdle muscle weakness (HP:0003749)1.77183221
69Aplasia/hypoplasia of the humerus (HP:0006507)1.75571623
70Optic nerve hypoplasia (HP:0000609)1.73905306
71Impaired smooth pursuit (HP:0007772)1.73669729
72Papilledema (HP:0001085)1.73216811
73Absence seizures (HP:0002121)1.72791808
74Focal motor seizures (HP:0011153)1.72424060
75Nephronophthisis (HP:0000090)1.71978475
76Midline defect of the nose (HP:0004122)1.71961468
77EEG with generalized epileptiform discharges (HP:0011198)1.71344987
78Hypoplastic female external genitalia (HP:0012815)1.71317106
79Nephroblastoma (Wilms tumor) (HP:0002667)1.70941041
80Neoplasm of the adrenal cortex (HP:0100641)1.70437283
81Impaired vibration sensation in the lower limbs (HP:0002166)1.69929992
82Mild short stature (HP:0003502)1.69820455
83Hypsarrhythmia (HP:0002521)1.69139321
84Hyperglycemia (HP:0003074)1.68791636
85Congenital primary aphakia (HP:0007707)1.68646001
86Hypoplastic ischia (HP:0003175)1.68572712
87Intestinal atresia (HP:0011100)1.68360291
88Abnormal number of incisors (HP:0011064)1.67873939
89Epileptiform EEG discharges (HP:0011182)1.67614632
90Absent eyebrow (HP:0002223)1.67418055
91Short tibia (HP:0005736)1.67047074
92Specific learning disability (HP:0001328)1.66793116
93Hypoglycemic seizures (HP:0002173)1.66388345
94Sleep apnea (HP:0010535)1.66276395
95Anophthalmia (HP:0000528)1.65270478
96Embryonal renal neoplasm (HP:0011794)1.64875437
97Abnormality of the hip-girdle musculature (HP:0001445)1.64563088
98Abnormality of the musculature of the pelvis (HP:0001469)1.64563088
99Neoplasm of striated muscle (HP:0009728)1.64501351
100Abnormality of the metopic suture (HP:0005556)1.64407140
101Ankyloglossia (HP:0010296)1.63795192
102Action tremor (HP:0002345)1.63452077
103Abnormality of calcium-phosphate metabolism (HP:0100530)1.63367024
104Truncal obesity (HP:0001956)1.63166173
105Limited hip movement (HP:0008800)1.62656400
106Rhabdomyosarcoma (HP:0002859)1.61876273
107Abnormality of the labia (HP:0000058)1.60834315
108Narrow forehead (HP:0000341)1.60823193
109High anterior hairline (HP:0009890)1.60727633
110Partial agenesis of the corpus callosum (HP:0001338)1.60250938
111Abnormality of the antihelix (HP:0009738)1.59850539
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59797481
113Short 4th metacarpal (HP:0010044)1.59797481
114Short 1st metacarpal (HP:0010034)1.59780991
115Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.59780991
116Ectopic anus (HP:0004397)1.59575421
117Polyphagia (HP:0002591)1.59415054
118Rib fusion (HP:0000902)1.59316766
119Abnormal respiratory epithelium morphology (HP:0012253)1.59255646
120Abnormal respiratory motile cilium morphology (HP:0005938)1.59255646
121Cerebellar dysplasia (HP:0007033)1.59235360
122Hypoventilation (HP:0002791)1.58578340
123Broad thumb (HP:0011304)1.58211432
124Renal hypoplasia (HP:0000089)1.58172749
125Omphalocele (HP:0001539)1.58025660
126Cutaneous syndactyly (HP:0012725)1.57703195
127Abnormality of midbrain morphology (HP:0002418)1.57688995
128Molar tooth sign on MRI (HP:0002419)1.57688995
129Lissencephaly (HP:0001339)1.57450432
130Deep palmar crease (HP:0006191)1.57351888
131Protruding tongue (HP:0010808)1.57152413
132Postaxial hand polydactyly (HP:0001162)1.56961862
133Short chin (HP:0000331)1.56812618
134Narrow nasal bridge (HP:0000446)1.56569236
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.56421074
136Hemiparesis (HP:0001269)1.56227906
137Gastroesophageal reflux (HP:0002020)1.55796734
138Medial flaring of the eyebrow (HP:0010747)1.54525176
139Cupped ear (HP:0000378)1.54298912
140Hypogonadotrophic hypogonadism (HP:0000044)1.54002726
141Facial hemangioma (HP:0000329)1.53743074
142Tubulointerstitial nephritis (HP:0001970)1.53689773
143Short foot (HP:0001773)1.53452065
144Micropenis (HP:0000054)1.53095656
145Genetic anticipation (HP:0003743)1.52652775
146Symptomatic seizures (HP:0011145)1.52516073
147Hypoplastic labia majora (HP:0000059)1.51799988
148Thickened helices (HP:0000391)1.51718030
149Abnormality of the renal medulla (HP:0100957)1.51545776
150Abnormality of the renal cortex (HP:0011035)1.50828374
151Cystic hygroma (HP:0000476)1.49969370
152Generalized tonic-clonic seizures (HP:0002069)1.49960481
153Abnormality of the pancreatic islet cells (HP:0006476)1.49941688
154Abnormality of endocrine pancreas physiology (HP:0012093)1.49941688
155Calf muscle hypertrophy (HP:0008981)1.49862141
156Pancreatic cysts (HP:0001737)1.49726664
157Coronal craniosynostosis (HP:0004440)1.48193549
158Esophageal atresia (HP:0002032)1.47504257
159Oligodactyly (HP:0012165)1.46873524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.57758175
2WNK33.37752021
3NTRK33.29648922
4MAP3K93.27081061
5PNCK2.84066219
6MAP3K42.65290257
7FRK2.54229962
8CDK122.38808839
9MAP4K22.36541575
10AKT32.28912438
11PASK2.27187914
12TNIK2.11133830
13OBSCN2.01067521
14LATS21.95672256
15KSR11.86154401
16UHMK11.84086373
17BRD41.82869921
18FGFR21.76578403
19NTRK21.73875711
20BCR1.71948898
21CDC71.65762135
22PRKD31.65622445
23PHKG21.65147175
24PHKG11.65147175
25MINK11.61519663
26STK38L1.58029977
27MAP2K71.44188946
28EIF2AK31.42204473
29PLK31.40995100
30SGK21.40528272
31ERBB31.35389013
32ALK1.32015467
33CAMKK21.30441753
34SCYL21.27841448
35PAK61.24011339
36PDK31.23577513
37PDK41.23577513
38SGK4941.19838772
39SGK2231.19838772
40TYRO31.19646094
41MAPK131.19529250
42CASK1.19184441
43TRIM281.18891824
44BRSK21.18308312
45BMPR1B1.17617628
46VRK11.10431513
47STK391.09329455
48MAP2K41.08977534
49ICK1.08118161
50CAMK1G1.07435686
51NEK11.06192737
52SRPK11.06142049
53EPHA21.03579394
54CSNK1G21.02633715
55PINK11.00140839
56CDC42BPA0.95645733
57OXSR10.93622957
58DYRK20.92828975
59EPHA40.92751347
60PDGFRA0.91875243
61PLK20.90327021
62TSSK60.89929905
63CSNK1G30.88604912
64CAMK1D0.88366966
65NTRK10.88249496
66PAK30.87111870
67DDR20.86758226
68INSRR0.85374835
69CSNK1E0.83191843
70ACVR1B0.82577017
71SGK30.82530332
72TTK0.82510348
73CHEK20.81580805
74CDK180.81329753
75CDK140.81295777
76STK30.80373230
77CHEK10.78459666
78NLK0.77875594
79EPHA30.77552904
80CDK150.75146311
81DYRK1A0.73929545
82MAPK150.72801309
83STK380.72639892
84CSNK1G10.72567167
85ATM0.72210775
86CAMK40.72151258
87KSR20.71965200
88PRKAA10.71252891
89PKN20.70978587
90LATS10.70089968
91MAP3K20.69977217
92CDK50.69807089
93PRKCE0.69569173
94CSNK1A1L0.69121074
95CDK20.68648455
96PLK10.66229073
97MTOR0.65710029
98CDK30.65504583
99CDK11A0.65140849
100NUAK10.65100547
101PLK40.64177528
102MKNK20.64130576
103CDK10.63235097
104MAPK100.62451485
105WEE10.61888962
106MAP3K120.61605009
107STK240.61566405
108PRKCG0.61386528
109CSNK1D0.61088051
110SIK20.60693469
111SIK30.58729076
112GSK3B0.58245035
113ZAK0.58123228
114ATR0.57399169
115FER0.56757688
116STK110.55914038
117BRAF0.55256166
118PRKDC0.54826836
119FGFR10.53279104
120MAPK140.51477536
121EEF2K0.50682514
122DYRK30.50509751
123MKNK10.49713689
124EPHB20.49575505
125CAMK10.49495092
126CAMKK10.49177722
127PRKCI0.48313665
128DAPK10.47692317
129FLT30.46638812
130MAP3K60.46585571
131TAF10.45076953
132PDK20.44950798
133GRK50.44096078
134RPS6KA30.43982526
135RPS6KB10.43039186
136SGK10.42031980
137TIE10.41041176
138RET0.40681469
139MAPK90.40428571
140CAMK2A0.39296177
141GRK10.39247144
142MELK0.39091292
143YES10.38325259
144CDK190.37557711
145CAMK2B0.37042557

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.71921110
2Insulin secretion_Homo sapiens_hsa049112.47549867
3Amphetamine addiction_Homo sapiens_hsa050312.26682405
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.18420335
5Synaptic vesicle cycle_Homo sapiens_hsa047212.13491153
6GABAergic synapse_Homo sapiens_hsa047272.12773514
7Cocaine addiction_Homo sapiens_hsa050302.11646704
8Long-term potentiation_Homo sapiens_hsa047201.98114640
9Dopaminergic synapse_Homo sapiens_hsa047281.96856819
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86890638
11Oocyte meiosis_Homo sapiens_hsa041141.83898995
12mRNA surveillance pathway_Homo sapiens_hsa030151.83698140
13Circadian entrainment_Homo sapiens_hsa047131.78379064
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71164307
15Morphine addiction_Homo sapiens_hsa050321.70028474
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64441718
17Hedgehog signaling pathway_Homo sapiens_hsa043401.58684089
18Alcoholism_Homo sapiens_hsa050341.56392943
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53883629
20RNA transport_Homo sapiens_hsa030131.53593907
21Taste transduction_Homo sapiens_hsa047421.50521005
22Basal cell carcinoma_Homo sapiens_hsa052171.49634862
23Serotonergic synapse_Homo sapiens_hsa047261.47551146
24Glutamatergic synapse_Homo sapiens_hsa047241.45627312
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44866290
26Wnt signaling pathway_Homo sapiens_hsa043101.41053765
27Type II diabetes mellitus_Homo sapiens_hsa049301.40913987
28Axon guidance_Homo sapiens_hsa043601.38464188
29Hippo signaling pathway_Homo sapiens_hsa043901.38454659
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37723636
31Estrogen signaling pathway_Homo sapiens_hsa049151.36221489
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36054067
33Non-homologous end-joining_Homo sapiens_hsa034501.33547872
34Melanogenesis_Homo sapiens_hsa049161.31987457
35Spliceosome_Homo sapiens_hsa030401.31185343
36Olfactory transduction_Homo sapiens_hsa047401.30710007
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25685272
38Dorso-ventral axis formation_Homo sapiens_hsa043201.24732190
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23702865
40Gap junction_Homo sapiens_hsa045401.23555858
41Type I diabetes mellitus_Homo sapiens_hsa049401.22552169
42Long-term depression_Homo sapiens_hsa047301.19763668
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19200793
44Glucagon signaling pathway_Homo sapiens_hsa049221.18880098
45Selenocompound metabolism_Homo sapiens_hsa004501.18479962
46Cholinergic synapse_Homo sapiens_hsa047251.17389803
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16703662
48Butanoate metabolism_Homo sapiens_hsa006501.12831022
49Inositol phosphate metabolism_Homo sapiens_hsa005621.11911570
50Protein export_Homo sapiens_hsa030601.09876270
51Renin secretion_Homo sapiens_hsa049241.07153216
52Propanoate metabolism_Homo sapiens_hsa006401.03389227
53Vibrio cholerae infection_Homo sapiens_hsa051101.02562304
54ErbB signaling pathway_Homo sapiens_hsa040120.99794960
55Oxytocin signaling pathway_Homo sapiens_hsa049210.99488264
56Cell cycle_Homo sapiens_hsa041100.97601579
57mTOR signaling pathway_Homo sapiens_hsa041500.95069588
58Mismatch repair_Homo sapiens_hsa034300.94562372
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93350828
60Salivary secretion_Homo sapiens_hsa049700.92936003
61Gastric acid secretion_Homo sapiens_hsa049710.90636447
62Thyroid hormone synthesis_Homo sapiens_hsa049180.90072494
63Endometrial cancer_Homo sapiens_hsa052130.88852771
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88598868
65Colorectal cancer_Homo sapiens_hsa052100.88321987
66Tight junction_Homo sapiens_hsa045300.87951896
67RNA degradation_Homo sapiens_hsa030180.86345581
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86257190
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85930759
70cAMP signaling pathway_Homo sapiens_hsa040240.85465673
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85188594
72GnRH signaling pathway_Homo sapiens_hsa049120.84428104
73Basal transcription factors_Homo sapiens_hsa030220.84341969
74Cardiac muscle contraction_Homo sapiens_hsa042600.83479517
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82781001
76Ovarian steroidogenesis_Homo sapiens_hsa049130.79468856
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79302890
78Calcium signaling pathway_Homo sapiens_hsa040200.78212377
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77087719
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75574418
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75323415
82Renal cell carcinoma_Homo sapiens_hsa052110.74581757
83MAPK signaling pathway_Homo sapiens_hsa040100.74548869
84Adherens junction_Homo sapiens_hsa045200.74020307
85MicroRNAs in cancer_Homo sapiens_hsa052060.73454514
86Fanconi anemia pathway_Homo sapiens_hsa034600.72111500
87Glioma_Homo sapiens_hsa052140.71788837
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71489466
89FoxO signaling pathway_Homo sapiens_hsa040680.69606842
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68938283
91Dilated cardiomyopathy_Homo sapiens_hsa054140.67778828
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.66854818
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66541996
94TGF-beta signaling pathway_Homo sapiens_hsa043500.66419877
95Circadian rhythm_Homo sapiens_hsa047100.66088676
96Steroid biosynthesis_Homo sapiens_hsa001000.64554385
97AMPK signaling pathway_Homo sapiens_hsa041520.64161329
98Prion diseases_Homo sapiens_hsa050200.64056007
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63020875
100Insulin signaling pathway_Homo sapiens_hsa049100.62938309
101Fatty acid biosynthesis_Homo sapiens_hsa000610.62931470
102Pancreatic secretion_Homo sapiens_hsa049720.62243211
103Regulation of autophagy_Homo sapiens_hsa041400.61215955
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60583459
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59125839
106Collecting duct acid secretion_Homo sapiens_hsa049660.58136214
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56874915
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56280200
109Ether lipid metabolism_Homo sapiens_hsa005650.53769808
110Nucleotide excision repair_Homo sapiens_hsa034200.53014289
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52653290
112Prostate cancer_Homo sapiens_hsa052150.51694225
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50074294
114Bladder cancer_Homo sapiens_hsa052190.49952725
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.49662906
116Thyroid cancer_Homo sapiens_hsa052160.48906059
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44996249
118Viral carcinogenesis_Homo sapiens_hsa052030.44911510
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.43917929
120Systemic lupus erythematosus_Homo sapiens_hsa053220.42514393
121Phototransduction_Homo sapiens_hsa047440.42454760
122Ras signaling pathway_Homo sapiens_hsa040140.41133852
123Lysine degradation_Homo sapiens_hsa003100.39622148

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