ZDHHC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.97859135
2motile cilium assembly (GO:0044458)8.78174068
3cilium movement (GO:0003341)8.18035228
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39931645
5epithelial cilium movement (GO:0003351)6.94622775
6left/right pattern formation (GO:0060972)6.16360998
7hyperosmotic salinity response (GO:0042538)4.93063296
8axoneme assembly (GO:0035082)4.80479522
9primary alcohol catabolic process (GO:0034310)4.47817084
10positive regulation of calcium ion import (GO:0090280)4.41690247
11aggressive behavior (GO:0002118)4.41154319
12negative regulation of cell size (GO:0045792)4.30706137
13synaptic vesicle maturation (GO:0016188)4.09458427
14regulation of transmission of nerve impulse (GO:0051969)3.89927471
15ventricular system development (GO:0021591)3.87590696
16regulation of synapse structural plasticity (GO:0051823)3.85698389
17regulation of female receptivity (GO:0045924)3.83074871
18ethanol metabolic process (GO:0006067)3.81485764
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79912547
20microtubule bundle formation (GO:0001578)3.72850047
21locomotory exploration behavior (GO:0035641)3.69305716
22positive regulation of vascular permeability (GO:0043117)3.64286786
23regulation of cilium movement (GO:0003352)3.57535723
24left/right axis specification (GO:0070986)3.55688034
25activation of protein kinase A activity (GO:0034199)3.53799305
26vitamin transmembrane transport (GO:0035461)3.52821828
27positive regulation of collagen biosynthetic process (GO:0032967)3.48132619
28protein kinase C signaling (GO:0070528)3.46540965
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42276199
30Golgi transport vesicle coating (GO:0048200)3.41099391
31COPI coating of Golgi vesicle (GO:0048205)3.41099391
32female mating behavior (GO:0060180)3.34957100
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34705863
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34288946
35glomerular epithelial cell development (GO:0072310)3.33469881
36maternal behavior (GO:0042711)3.31388414
37lung epithelium development (GO:0060428)3.30662629
38tooth mineralization (GO:0034505)3.28179690
39positive regulation of collagen metabolic process (GO:0010714)3.27410745
40cell communication by electrical coupling (GO:0010644)3.21372999
41establishment of apical/basal cell polarity (GO:0035089)3.21044141
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21042196
43positive regulation of fatty acid biosynthetic process (GO:0045723)3.16332111
44lymph vessel development (GO:0001945)3.16234601
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.15406769
46cytoplasmic microtubule organization (GO:0031122)3.15103503
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14180713
48drinking behavior (GO:0042756)3.13719687
49regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.13620047
50multicellular organismal water homeostasis (GO:0050891)3.13353542
51positive regulation of amino acid transport (GO:0051957)3.12903544
52synaptic vesicle exocytosis (GO:0016079)3.12765928
53amyloid precursor protein catabolic process (GO:0042987)3.11266718
54glutamate secretion (GO:0014047)3.05531892
55positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.04102844
56regulation of response to osmotic stress (GO:0047484)3.02909757
57intraciliary transport (GO:0042073)3.02898290
58regulation of synaptic vesicle exocytosis (GO:2000300)2.97813380
59negative regulation of digestive system process (GO:0060457)2.96414249
60diterpenoid biosynthetic process (GO:0016102)2.96207611
61sodium ion export (GO:0071436)2.95129636
62plasma membrane repair (GO:0001778)2.94990253
63parental behavior (GO:0060746)2.94955425
64negative regulation of necrotic cell death (GO:0060547)2.94813287
65positive regulation of multicellular organismal metabolic process (GO:0044253)2.94649437
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.94127584
67potassium ion import (GO:0010107)2.91095528
68regulation of collagen biosynthetic process (GO:0032965)2.90628798
69regulation of synaptic vesicle transport (GO:1902803)2.90455861
70postsynaptic membrane organization (GO:0001941)2.89788009
71positive regulation of systemic arterial blood pressure (GO:0003084)2.88334497
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87549315
73cellular potassium ion homeostasis (GO:0030007)2.85562708
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82352097
75protein retention in ER lumen (GO:0006621)2.80997124
76extracellular fibril organization (GO:0043206)2.78516144
77positive regulation of smoothened signaling pathway (GO:0045880)2.73715821
78barbed-end actin filament capping (GO:0051016)2.73680010
79sperm capacitation (GO:0048240)2.73316612
80dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.72449216
81metanephric mesenchyme development (GO:0072075)2.72164355
82ethanol oxidation (GO:0006069)2.72007496
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70051669
84negative regulation of T cell differentiation in thymus (GO:0033085)2.70019091
85kidney mesenchyme development (GO:0072074)2.69240444
86establishment or maintenance of monopolar cell polarity (GO:0061339)2.69140740
87establishment of monopolar cell polarity (GO:0061162)2.69140740
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68865821
89membrane depolarization during action potential (GO:0086010)2.68269322
90membrane repolarization (GO:0086009)2.67839361
91regulation of collagen metabolic process (GO:0010712)2.65927972
92membrane repolarization during action potential (GO:0086011)2.65160106
93mitochondrial calcium ion transport (GO:0006851)2.64797750
94vocalization behavior (GO:0071625)2.63637878
95one-carbon compound transport (GO:0019755)2.62726620
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62017411
97regulation of membrane repolarization (GO:0060306)2.61170096
98cilium organization (GO:0044782)2.60634812
99neuronal action potential propagation (GO:0019227)2.60529501
100regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60260554
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59542676
102regulation of glucocorticoid secretion (GO:2000849)2.59128584
103growth hormone secretion (GO:0030252)2.58687744
104negative regulation of humoral immune response (GO:0002921)2.58266249
105regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57996314
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.57673764
107detection of calcium ion (GO:0005513)2.56361062
108neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55184810
109regulation of calcium ion transmembrane transporter activity (GO:1901019)2.54792837
110regulation of calcium ion transmembrane transport (GO:1903169)2.54792837
111regulation of corticosteroid hormone secretion (GO:2000846)2.54674720
112neuronal ion channel clustering (GO:0045161)2.54494010
113regulation of neuronal synaptic plasticity (GO:0048168)2.53722893
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53452127
115cilium assembly (GO:0042384)2.53382937
116peptidyl-tyrosine autophosphorylation (GO:0038083)2.52919277
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51783365
118regulation of calcium ion import (GO:0090279)2.51659626
119neurotransmitter secretion (GO:0007269)2.50720121
120establishment of planar polarity (GO:0001736)2.49899260
121establishment of tissue polarity (GO:0007164)2.49899260
122pyrimidine-containing compound transmembrane transport (GO:0072531)2.48571513
123lateral ventricle development (GO:0021670)2.48486176
124regulation of glutamate secretion (GO:0014048)2.48404335
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48082223
126negative regulation of response to food (GO:0032096)2.47630308
127negative regulation of appetite (GO:0032099)2.47630308
128water homeostasis (GO:0030104)2.47295911
129suckling behavior (GO:0001967)2.46980518
130regulation of glutamate receptor signaling pathway (GO:1900449)2.46854042
131regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.46606690
132semaphorin-plexin signaling pathway (GO:0071526)2.46098668
133cAMP biosynthetic process (GO:0006171)2.45768278
134regulation of interleukin-13 production (GO:0032656)2.45734681
135positive regulation of vesicle fusion (GO:0031340)2.45564354
136definitive hemopoiesis (GO:0060216)2.44017797
137neuromuscular process controlling posture (GO:0050884)2.43334526
138potassium ion export (GO:0071435)2.43034436
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.42541316
140exploration behavior (GO:0035640)2.41857307
141negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41278853
142positive regulation of catecholamine secretion (GO:0033605)2.40949567
143calcium ion-dependent exocytosis (GO:0017156)2.40693167
144cellular sodium ion homeostasis (GO:0006883)2.40458085
145regulation of multicellular organismal metabolic process (GO:0044246)2.39493897
146lactate metabolic process (GO:0006089)2.39334647
147establishment of nucleus localization (GO:0040023)2.38906341
148positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.38748042
149cell communication involved in cardiac conduction (GO:0086065)2.38035562
150blood vessel maturation (GO:0001955)2.36852809
151regulation of axon extension involved in axon guidance (GO:0048841)2.36348826
152microtubule-based movement (GO:0007018)2.35477877
153tolerance induction (GO:0002507)2.34571841
154regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33812232
155neuromuscular junction development (GO:0007528)2.33085671
156cardiac muscle contraction (GO:0060048)2.32949508
157potassium ion homeostasis (GO:0055075)2.32655832
158peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.31844026
159induction of positive chemotaxis (GO:0050930)2.31521501
160negative regulation of norepinephrine secretion (GO:0010700)2.31199241
161regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.30058187
162neuromuscular process controlling balance (GO:0050885)2.29719187
163regulation of glucocorticoid metabolic process (GO:0031943)2.29640743
164cardiolipin metabolic process (GO:0032048)2.29605416
165regulation of vesicle fusion (GO:0031338)2.29589397
166fibril organization (GO:0097435)2.29014112
167cochlea morphogenesis (GO:0090103)2.28969692
168regulation of interleukin-5 production (GO:0032674)2.28601649
169hyperosmotic response (GO:0006972)2.28566695
170insulin secretion (GO:0030073)2.27658340
171positive regulation of digestive system process (GO:0060456)2.26912363
172auditory behavior (GO:0031223)2.26893452
173positive regulation of odontogenesis (GO:0042482)2.26701257
174type B pancreatic cell proliferation (GO:0044342)2.26451947
175glycine transport (GO:0015816)2.25841427
176positive regulation of membrane potential (GO:0045838)2.25695236
177cellular response to glucagon stimulus (GO:0071377)2.22653284
178insulin-like growth factor receptor signaling pathway (GO:0048009)2.20485821
179positive regulation of potassium ion transport (GO:0043268)2.20324191
180positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.19911435
181sodium ion homeostasis (GO:0055078)2.17818585
182dendrite morphogenesis (GO:0048813)2.17108923
183protein targeting to plasma membrane (GO:0072661)2.16807346
184stress fiber assembly (GO:0043149)2.16262618
185cerebellar Purkinje cell layer development (GO:0021680)2.15982515
186proline transport (GO:0015824)2.15302440
187cardiac conduction (GO:0061337)2.14731175
188regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.13745464
189regulation of ARF protein signal transduction (GO:0032012)2.13718312
190response to auditory stimulus (GO:0010996)2.13264815
191regulation of cation channel activity (GO:2001257)2.12730597
192negative regulation of erythrocyte differentiation (GO:0045647)2.11414982
193response to pheromone (GO:0019236)2.11242419
194chemosensory behavior (GO:0007635)2.10924484
195venous blood vessel morphogenesis (GO:0048845)2.10268953
196positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.10097048
197anatomical structure maturation (GO:0071695)2.09618592
198axonemal dynein complex assembly (GO:0070286)12.3669217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55107431
2DROSHA_22980978_ChIP-Seq_HELA_Human2.56944189
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39488271
4MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36310359
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35188113
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34093621
7* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32388458
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.31639215
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29655995
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28909826
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20057064
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20057064
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19172125
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.18358657
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06483066
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04702756
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00463895
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99777867
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99668314
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96824748
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.92410476
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.92393199
23ZNF274_21170338_ChIP-Seq_K562_Hela1.88923733
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.86724639
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.85302041
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78162948
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76752624
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.73988811
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69388529
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68571407
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68168146
32GATA1_22025678_ChIP-Seq_K562_Human1.67444045
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.66495810
34* ELF1_20517297_ChIP-Seq_JURKAT_Human1.64487048
35KDM2B_26808549_Chip-Seq_K562_Human1.62195190
36LXR_22292898_ChIP-Seq_THP-1_Human1.61202929
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55954674
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.55519516
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54481335
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52540021
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52469382
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50387772
43REST_21632747_ChIP-Seq_MESCs_Mouse1.49261620
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48753317
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48590197
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48504164
47TP53_22127205_ChIP-Seq_IMR90_Human1.45949670
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45638436
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40510478
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.39528307
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39398695
52* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38824708
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.35984960
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.35941482
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.35210728
56GBX2_23144817_ChIP-Seq_PC3_Human1.34716990
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33599202
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.32043852
59* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31702618
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30751269
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.29896646
62* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29412742
63BCL6_27268052_Chip-Seq_Bcells_Human1.29184573
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28545530
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26216769
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26113630
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26062030
68ZNF263_19887448_ChIP-Seq_K562_Human1.26059961
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24794813
70SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24088633
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.22297784
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21958345
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21696626
74CTCF_27219007_Chip-Seq_Bcells_Human1.21648668
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20297565
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17897740
77VDR_21846776_ChIP-Seq_THP-1_Human1.16394757
78SMC4_20622854_ChIP-Seq_HELA_Human1.15859597
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15345134
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14747134
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.13497078
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12646336
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12197740
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12028438
85KDM2B_26808549_Chip-Seq_DND41_Human1.11808338
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11763644
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11477187
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11233265
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.10628777
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.10628777
91KLF5_25053715_ChIP-Seq_YYC3_Human1.09588006
92BCOR_27268052_Chip-Seq_Bcells_Human1.08794638
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07942347
94SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05155434
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.03783966
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03462361
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.02918610
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02665363
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.02420367
100SCL_19346495_ChIP-Seq_HPC-7_Human1.02120891
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98719171
102E2F1_20622854_ChIP-Seq_HELA_Human0.98408054
103* TP63_22573176_ChIP-Seq_HFKS_Human0.98282078
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98082216
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97280510
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96723416
107PHF8_20622854_ChIP-Seq_HELA_Human0.96695074
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96085510
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.94931253
110RACK7_27058665_Chip-Seq_MCF-7_Human0.94682209
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94358117
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94300117
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.93720899
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.93139000
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92849126
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92761229
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92222132
118AR_19668381_ChIP-Seq_PC3_Human0.91848706
119STAT1_20625510_ChIP-Seq_HELA_Human0.91830176
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90854344
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.90227183
122* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90150964
123CREB1_26743006_Chip-Seq_LNCaP_Human0.89599902
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.88917411
125KLF4_19829295_ChIP-Seq_ESCs_Human0.88183065
126TCF7_22412390_ChIP-Seq_EML_Mouse0.87705147
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86501831
128CLOCK_20551151_ChIP-Seq_293T_Human0.86443174
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.85038616
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84944585
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84838733
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84669583
133P68_20966046_ChIP-Seq_HELA_Human0.84328234
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82981428
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82427376
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82112036
137GATA1_19941826_ChIP-Seq_K562_Human0.81571596
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.81257594
139SPI1_23127762_ChIP-Seq_K562_Human0.81197337
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.80354536
141CTCF_20526341_ChIP-Seq_ESCs_Human0.79928631
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78542507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.66718391
2MP0000751_myopathy3.06501436
3MP0000013_abnormal_adipose_tissue3.05506227
4MP0002909_abnormal_adrenal_gland2.75896703
5MP0008875_abnormal_xenobiotic_pharmacok2.73897429
6MP0003283_abnormal_digestive_organ2.66621730
7MP0003635_abnormal_synaptic_transmissio2.37599371
8MP0005397_hematopoietic_system_phenotyp2.29190354
9MP0001545_abnormal_hematopoietic_system2.29190354
10MP0002837_dystrophic_cardiac_calcinosis2.28590375
11MP0009780_abnormal_chondrocyte_physiolo2.21678348
12MP0009840_abnormal_foam_cell2.19401708
13MP0000681_abnormal_thyroid_gland2.11104814
14MP0004782_abnormal_surfactant_physiolog2.10009851
15MP0010368_abnormal_lymphatic_system2.09602605
16MP0002249_abnormal_larynx_morphology2.06941295
17MP0005058_abnormal_lysosome_morphology2.04288121
18MP0002132_abnormal_respiratory_system2.03103012
19MP0003191_abnormal_cellular_cholesterol2.00593215
20MP0010030_abnormal_orbit_morphology1.97040732
21MP0003705_abnormal_hypodermis_morpholog1.93599586
22MP0005646_abnormal_pituitary_gland1.92763387
23MP0008789_abnormal_olfactory_epithelium1.87400127
24MP0008961_abnormal_basal_metabolism1.85881283
25MP0002877_abnormal_melanocyte_morpholog1.85079179
26MP0004270_analgesia1.84756211
27MP0004858_abnormal_nervous_system1.81947750
28MP0008438_abnormal_cutaneous_collagen1.80607129
29MP0004043_abnormal_pH_regulation1.79271135
30MP0003122_maternal_imprinting1.77608344
31MP0004084_abnormal_cardiac_muscle1.75063311
32MP0004036_abnormal_muscle_relaxation1.69725389
33MP0001958_emphysema1.65038871
34MP0001984_abnormal_olfaction1.64028555
35MP0005508_abnormal_skeleton_morphology1.63236803
36MP0004145_abnormal_muscle_electrophysio1.61943618
37MP0002234_abnormal_pharynx_morphology1.60833552
38MP0005503_abnormal_tendon_morphology1.59942219
39MP0000749_muscle_degeneration1.59453137
40MP0009745_abnormal_behavioral_response1.58477850
41MP0004215_abnormal_myocardial_fiber1.58133154
42MP0002064_seizures1.56558441
43MP0000003_abnormal_adipose_tissue1.54373135
44MP0004130_abnormal_muscle_cell1.54177504
45MP0008569_lethality_at_weaning1.50685753
46MP0002272_abnormal_nervous_system1.49592768
47MP0010386_abnormal_urinary_bladder1.47624990
48MP0000534_abnormal_ureter_morphology1.46604832
49MP0005451_abnormal_body_composition1.45962926
50MP0000465_gastrointestinal_hemorrhage1.41882800
51MP0002063_abnormal_learning/memory/cond1.40114965
52MP0001270_distended_abdomen1.39187822
53MP0005023_abnormal_wound_healing1.38998005
54MP0009046_muscle_twitch1.37615310
55MP0003279_aneurysm1.37361406
56MP0006054_spinal_hemorrhage1.36264507
57MP0001944_abnormal_pancreas_morphology1.35707014
58MP0004885_abnormal_endolymph1.34554125
59MP0001542_abnormal_bone_strength1.34091472
60MP0004272_abnormal_basement_membrane1.33122140
61MP0001502_abnormal_circadian_rhythm1.31105724
62MP0004233_abnormal_muscle_weight1.31025244
63MP0009384_cardiac_valve_regurgitation1.30300903
64MP0005167_abnormal_blood-brain_barrier1.30239800
65MP0004085_abnormal_heartbeat1.27694731
66MP0002282_abnormal_trachea_morphology1.26559278
67MP0003566_abnormal_cell_adhesion1.26536000
68MP0003300_gastrointestinal_ulcer1.25952421
69MP0001765_abnormal_ion_homeostasis1.25453942
70MP0001968_abnormal_touch/_nociception1.24604963
71MP0000678_abnormal_parathyroid_gland1.24502920
72MP0004133_heterotaxia1.23382125
73MP0000747_muscle_weakness1.23316328
74MP0001501_abnormal_sleep_pattern1.23286667
75MP0000566_synostosis1.22626036
76MP0002734_abnormal_mechanical_nocicepti1.22560501
77MP0003137_abnormal_impulse_conducting1.22248595
78MP0005257_abnormal_intraocular_pressure1.20621615
79MP0002572_abnormal_emotion/affect_behav1.19305882
80MP0005275_abnormal_skin_tensile1.17682534
81MP0001879_abnormal_lymphatic_vessel1.17572615
82MP0005499_abnormal_olfactory_system1.16921342
83MP0005394_taste/olfaction_phenotype1.16921342
84MP0002653_abnormal_ependyma_morphology1.15759214
85MP0005623_abnormal_meninges_morphology1.14029778
86MP0002736_abnormal_nociception_after1.13012602
87MP0003879_abnormal_hair_cell1.12995812
88MP0002295_abnormal_pulmonary_circulatio1.12697681
89MP0001664_abnormal_digestion1.12420621
90MP0002089_abnormal_postnatal_growth/wei1.11581054
91MP0002060_abnormal_skin_morphology1.11392737
92MP0003183_abnormal_peptide_metabolism1.10243109
93MP0002557_abnormal_social/conspecific_i1.10102742
94MP0003329_amyloid_beta_deposits1.09222200
95MP0003075_altered_response_to1.08920854
96MP0003045_fibrosis1.06948886
97MP0003633_abnormal_nervous_system1.05256277
98MP0008004_abnormal_stomach_pH1.04317261
99MP0002733_abnormal_thermal_nociception1.04204348
100MP0002693_abnormal_pancreas_physiology1.04006257
101MP0001486_abnormal_startle_reflex1.03563001
102MP0003172_abnormal_lysosome_physiology1.02861074
103MP0000604_amyloidosis1.02493056
104MP0000955_abnormal_spinal_cord1.01632402
105MP0002108_abnormal_muscle_morphology1.00783602
106MP0005390_skeleton_phenotype0.99463667
107MP0005369_muscle_phenotype0.99231958
108MP0005220_abnormal_exocrine_pancreas0.99051684
109MP0002106_abnormal_muscle_physiology0.96752481
110MP0005666_abnormal_adipose_tissue0.96381371
111MP0002735_abnormal_chemical_nociception0.96020872
112MP0003880_abnormal_central_pattern0.95989699
113MP0002067_abnormal_sensory_capabilities0.95680883
114MP0005375_adipose_tissue_phenotype0.94712096
115MP0001299_abnormal_eye_distance/0.94403918
116MP0005620_abnormal_muscle_contractility0.94170093
117MP0001970_abnormal_pain_threshold0.93959962
118MP0003091_abnormal_cell_migration0.93467210
119MP0006138_congestive_heart_failure0.92923905
120MP0002269_muscular_atrophy0.92763155
121MP0000759_abnormal_skeletal_muscle0.92537417
122MP0004087_abnormal_muscle_fiber0.91829298
123MP0005164_abnormal_response_to0.91606418
124MP0003787_abnormal_imprinting0.91482597
125MP0002233_abnormal_nose_morphology0.91360956
126MP0002896_abnormal_bone_mineralization0.89553440
127MP0004811_abnormal_neuron_physiology0.88952355
128MP0002184_abnormal_innervation0.85821659
129MP0000049_abnormal_middle_ear0.84345253
130MP0001849_ear_inflammation0.83933266
131MP0005645_abnormal_hypothalamus_physiol0.83722157
132MP0005670_abnormal_white_adipose0.83687503
133MP0002972_abnormal_cardiac_muscle0.81766223
134MP0001851_eye_inflammation0.81735268
135MP0002971_abnormal_brown_adipose0.81217457
136MP0002078_abnormal_glucose_homeostasis0.80328501
137MP0000767_abnormal_smooth_muscle0.79915053
138MP0005330_cardiomyopathy0.79748952
139MP0009278_abnormal_bone_marrow0.79622696
140MP0000249_abnormal_blood_vessel0.78377864
141MP0002796_impaired_skin_barrier0.77882235
142MP0004883_abnormal_blood_vessel0.77353079
143MP0002933_joint_inflammation0.76187194
144MP0009379_abnormal_foot_pigmentation0.74977628
145MP0002168_other_aberrant_phenotype0.74312884
146MP0000733_abnormal_muscle_development0.71823859
147MP0005595_abnormal_vascular_smooth0.70993798
148MP0000639_abnormal_adrenal_gland0.70354774
149MP0002116_abnormal_craniofacial_bone0.69050306
150MP0005165_increased_susceptibility_to0.68874387
151MP0000467_abnormal_esophagus_morphology0.68049015
152MP0002932_abnormal_joint_morphology0.66313922
153MP0002638_abnormal_pupillary_reflex0.65613734
154MP0003634_abnormal_glial_cell0.64575108
155MP0001346_abnormal_lacrimal_gland0.63896546
156MP0005083_abnormal_biliary_tract0.63356680
157MP0005395_other_phenotype0.61072868
158MP0002128_abnormal_blood_circulation0.60876754
159MP0003942_abnormal_urinary_system0.59733663
160MP0003453_abnormal_keratinocyte_physiol0.59468253
161MP0002998_abnormal_bone_remodeling0.58804326
162MP0000163_abnormal_cartilage_morphology0.58333533
163MP0001533_abnormal_skeleton_physiology0.57096348
164MP0001614_abnormal_blood_vessel0.55621786
165MP0002277_abnormal_respiratory_mucosa0.55503035
166MP0002133_abnormal_respiratory_system0.54886307
167MP0005388_respiratory_system_phenotype0.54886307

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.84487753
2Abnormal respiratory epithelium morphology (HP:0012253)8.52563091
3Abnormal respiratory motile cilium morphology (HP:0005938)8.52563091
4Abnormal respiratory motile cilium physiology (HP:0012261)8.25876257
5Abnormal ciliary motility (HP:0012262)8.12718606
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.03105526
7Absent/shortened dynein arms (HP:0200106)8.03105526
8Rhinitis (HP:0012384)7.81889458
9Nasal polyposis (HP:0100582)6.09955377
10Bronchiectasis (HP:0002110)5.20839813
11Atelectasis (HP:0100750)4.06396582
12Broad metatarsal (HP:0001783)3.94815266
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.44589351
14Infertility (HP:0000789)3.37341510
15Male infertility (HP:0003251)3.31608039
16Occipital encephalocele (HP:0002085)3.11601016
17Ankle clonus (HP:0011448)2.96097965
18Visual hallucinations (HP:0002367)2.95940558
19Bundle branch block (HP:0011710)2.95846756
20Bronchitis (HP:0012387)2.95794278
21Cerebral aneurysm (HP:0004944)2.92784052
22Protrusio acetabuli (HP:0003179)2.90706958
23Recurrent sinusitis (HP:0011108)2.84927522
24Increased variability in muscle fiber diameter (HP:0003557)2.84649235
25Bell-shaped thorax (HP:0001591)2.79741362
26Large for gestational age (HP:0001520)2.78931292
27Recurrent otitis media (HP:0000403)2.74397727
28Prolonged QT interval (HP:0001657)2.69392852
29Chronic sinusitis (HP:0011109)2.65746039
30Decreased circulating renin level (HP:0003351)2.62125869
31Neoplasm of the heart (HP:0100544)2.62111968
32Hypoventilation (HP:0002791)2.55201855
33Premature rupture of membranes (HP:0001788)2.52609275
34Spinal canal stenosis (HP:0003416)2.52088527
35Ventricular fibrillation (HP:0001663)2.44500838
36Arterial tortuosity (HP:0005116)2.38631134
37Ketoacidosis (HP:0001993)2.37838959
38Abnormality of skeletal muscle fiber size (HP:0012084)2.37189020
39Myoglobinuria (HP:0002913)2.35964723
40Exercise-induced myalgia (HP:0003738)2.34900875
41Asymmetric septal hypertrophy (HP:0001670)2.28006054
42Aortic aneurysm (HP:0004942)2.27383535
43Distal upper limb amyotrophy (HP:0007149)2.25936709
44Upper limb amyotrophy (HP:0009129)2.25936709
45Myokymia (HP:0002411)2.25189706
46Long toe (HP:0010511)2.23780902
47Vascular tortuosity (HP:0004948)2.22865011
48Abnormal EKG (HP:0003115)2.20411066
49Depression (HP:0000716)2.19901515
50Abnormality of dentin (HP:0010299)2.18330154
51Focal motor seizures (HP:0011153)2.16599145
52Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.12886083
53Bladder diverticulum (HP:0000015)2.12536963
54Atrial fibrillation (HP:0005110)2.12525288
55Abnormality of the nasal mucosa (HP:0000433)2.11743598
56Absent frontal sinuses (HP:0002688)2.11211030
57Anxiety (HP:0000739)2.10448641
58Nonprogressive disorder (HP:0003680)2.10357539
59Distal lower limb muscle weakness (HP:0009053)2.10132619
60Supranuclear gaze palsy (HP:0000605)2.09245126
61Aneurysm (HP:0002617)2.08641664
62Short nail (HP:0001799)2.08394853
63Hand muscle atrophy (HP:0009130)2.07775823
64Myotonia (HP:0002486)2.06827473
65Fatigue (HP:0012378)2.06260713
66Striae distensae (HP:0001065)2.04124543
67Hyperinsulinemic hypoglycemia (HP:0000825)2.03876995
68Hyperkalemia (HP:0002153)2.03317444
69Type 1 muscle fiber predominance (HP:0003803)2.02530170
70Hypercortisolism (HP:0001578)2.02431469
71Obstructive sleep apnea (HP:0002870)2.00364013
72Chronic otitis media (HP:0000389)1.99992949
73Primary atrial arrhythmia (HP:0001692)1.98746928
74Hyperacusis (HP:0010780)1.97573078
75Mildly elevated creatine phosphokinase (HP:0008180)1.97290853
76Torticollis (HP:0000473)1.97287927
77Aortic dissection (HP:0002647)1.96917524
78Spinal rigidity (HP:0003306)1.96537686
79Hyperactive renin-angiotensin system (HP:0000841)1.95385771
80Growth hormone excess (HP:0000845)1.94435625
81Supraventricular arrhythmia (HP:0005115)1.94136827
82Stridor (HP:0010307)1.93966319
83Supraventricular tachycardia (HP:0004755)1.93279368
84Menstrual irregularities (HP:0000858)1.92244208
85Shallow orbits (HP:0000586)1.91998661
86Bronchomalacia (HP:0002780)1.91919340
87Abnormality of the distal phalanges of the toes (HP:0010182)1.91735649
88Turricephaly (HP:0000262)1.91358118
89Action tremor (HP:0002345)1.91257448
90Focal seizures (HP:0007359)1.90925404
91Myopathic facies (HP:0002058)1.90429786
92Enlarged penis (HP:0000040)1.88810426
93Abnormality of calcium-phosphate metabolism (HP:0100530)1.88622726
94Mucopolysacchariduria (HP:0008155)1.88176697
95Urinary glycosaminoglycan excretion (HP:0003541)1.88176697
96Bradycardia (HP:0001662)1.85248765
97Cystic liver disease (HP:0006706)1.85184224
98Ankle contracture (HP:0006466)1.84207719
99Chronic bronchitis (HP:0004469)1.83405126
100Sudden death (HP:0001699)1.82868335
101Abnormality of renin-angiotensin system (HP:0000847)1.82000318
102Cervical subluxation (HP:0003308)1.81662677
103Agitation (HP:0000713)1.80894952
104Insomnia (HP:0100785)1.80104385
105Vertebral compression fractures (HP:0002953)1.79068181
106Insulin-resistant diabetes mellitus (HP:0000831)1.78348912
107Dysostosis multiplex (HP:0000943)1.77623801
108Interstitial pulmonary disease (HP:0006530)1.77266522
109Macroorchidism (HP:0000053)1.75269877
110Type II lissencephaly (HP:0007260)1.75133568
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74962768
112Abnormality of polysaccharide metabolism (HP:0011012)1.74962768
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74962768
114Abnormality of the pancreatic islet cells (HP:0006476)1.74580793
115Abnormality of endocrine pancreas physiology (HP:0012093)1.74580793
116Heart block (HP:0012722)1.73552457
117Scanning speech (HP:0002168)1.72230445
118Adrenal overactivity (HP:0002717)1.71916283
119Impaired vibration sensation in the lower limbs (HP:0002166)1.71858985
120Down-sloping shoulders (HP:0200021)1.71832273
121Genetic anticipation (HP:0003743)1.70448325
122Gout (HP:0001997)1.70279300
123Thin bony cortex (HP:0002753)1.68792652
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68468582
125Focal dystonia (HP:0004373)1.67692789
126Hemiplegia (HP:0002301)1.67657166
127Postural instability (HP:0002172)1.66968520
128Syncope (HP:0001279)1.66914645
129Soft skin (HP:0000977)1.66524716
130Abnormality of the calf musculature (HP:0001430)1.65918060
131Neoplasm of the rectum (HP:0100743)1.64730095
132Limb-girdle muscle atrophy (HP:0003797)1.64513678
133Abnormal atrioventricular conduction (HP:0005150)1.64192492
134Tubulointerstitial nephritis (HP:0001970)1.61470979
135Pulmonary artery stenosis (HP:0004415)1.59557433
136Joint stiffness (HP:0001387)1.58406393
137Muscle fiber splitting (HP:0003555)1.56509108
138Ulnar bowing (HP:0003031)1.56176961
139Aortic regurgitation (HP:0001659)1.55264712
140Overriding aorta (HP:0002623)1.51464241
141True hermaphroditism (HP:0010459)1.49249977
142Abnormal vertebral ossification (HP:0100569)1.48361439
143Renovascular hypertension (HP:0100817)1.47751453
144Elfin facies (HP:0004428)1.47565450
145Pancreatic fibrosis (HP:0100732)1.46683598
146Renal salt wasting (HP:0000127)1.41712481
147Neonatal short-limb short stature (HP:0008921)1.41442816
148Molar tooth sign on MRI (HP:0002419)1.39890519
149Abnormality of midbrain morphology (HP:0002418)1.39890519
150Broad distal phalanx of finger (HP:0009836)1.39312615
151Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.39185442
152Atrophic scars (HP:0001075)1.38793903
153Venous insufficiency (HP:0005293)1.36982284
154Increased connective tissue (HP:0009025)1.35823097
155Postaxial foot polydactyly (HP:0001830)1.35541919
156Short femoral neck (HP:0100864)1.35094511
157Hypercalciuria (HP:0002150)1.33900499
158Venous abnormality (HP:0002624)1.33521496
159Nuclear cataract (HP:0100018)1.33310861
160Fragile skin (HP:0001030)1.32951403
161Wormian bones (HP:0002645)1.32669053
162Flat acetabular roof (HP:0003180)1.32375991
163Epiphyseal dysplasia (HP:0002656)1.32224040
164Joint laxity (HP:0001388)1.31847624
165Abnormality of molar morphology (HP:0011070)1.30546533
166Abnormality of molar (HP:0011077)1.30546533
167Nephronophthisis (HP:0000090)1.30415895
168Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.29804953
169Alacrima (HP:0000522)1.29319750
170Abnormality of complement system (HP:0005339)1.29068879
171Complement deficiency (HP:0004431)1.28726238
172Narrow chest (HP:0000774)1.28165830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K114.50810465
2PRKD33.93056662
3EPHA23.84408965
4TRIB33.24970169
5SMG12.86712549
6NTRK32.61999863
7TIE12.44628145
8NME12.34897591
9DYRK1B2.33800678
10MAPK152.28064057
11LMTK22.11162458
12CAMKK22.11024836
13MAP3K42.10558422
14TESK12.01302849
15ERN11.92443751
16PKN21.81340173
17CAMKK11.78642984
18KSR21.75686165
19MAP4K11.74887215
20NTRK11.72024498
21MAP2K71.71168603
22DAPK21.64372605
23MAP3K131.60075454
24CAMK1D1.58926502
25WNK41.57319714
26RIPK11.55842523
27TTN1.55284463
28PHKG11.55245974
29PHKG21.55245974
30RET1.53697835
31MAP3K21.52351510
32DMPK1.52137027
33CAMK1G1.48871488
34NEK91.43559907
35PAK61.43224826
36INSRR1.38821506
37MAP3K31.37109681
38MUSK1.34200060
39MAP2K21.33011278
40PDGFRA1.30916022
41MAP3K91.28986039
42PTK61.25525365
43PINK11.25257733
44MYLK1.22506802
45CDK191.21536682
46MAP2K41.21105280
47CAMK11.18882791
48FER1.16454548
49EPHB21.12983289
50HIPK21.12775207
51MINK11.11663841
52TNIK1.11174126
53STK381.10920536
54PRKCH1.10229115
55NTRK21.06846580
56EPHA41.06680838
57PASK1.05758038
58PAK31.04626470
59MAP3K11.03968155
60TGFBR21.03135420
61MST1R1.02954847
62MARK21.02878419
63PIM21.00583117
64TBK10.98094692
65PTK2B0.95033303
66PIK3CG0.94375755
67PTK20.93471602
68WNK10.93292323
69MAP3K70.92128414
70RPS6KA20.90153402
71ABL20.88974489
72MET0.87910995
73KDR0.87506211
74EEF2K0.87332786
75KSR10.85977355
76SIK10.82842763
77EPHB10.81951189
78UHMK10.80312028
79CDK50.77343922
80ICK0.75328457
81DAPK10.75278007
82MTOR0.73163846
83DDR20.72149500
84PRKG20.70977274
85ARAF0.70241985
86CDC42BPA0.69989726
87FLT30.69954127
88PDPK10.68919833
89TGFBR10.68911674
90WNK30.68804599
91EPHA30.68342806
92PDK30.68164128
93PDK40.68164128
94SIK30.65955142
95PRKD20.65164780
96CSK0.65086693
97RAF10.63686995
98LIMK10.63183837
99BCKDK0.62344068
100GRK10.61353989
101CAMK40.60403675
102SCYL20.59321779
103CDK30.58160141
104ILK0.57373753
105MAP2K10.57325597
106STK240.57197095
107MST40.56989949
108PRKAA20.56855774
109GRK50.56845506
110ERBB30.56185918
111ROCK10.54765648
112PAK20.54264297
113PRKD10.53990558
114ROCK20.53624315
115DYRK1A0.52966560
116MAPKAPK30.52659564
117CDK90.51511475
118MAP2K30.49771089
119PKN10.49310241
120CAMK2D0.48908567
121RPS6KC10.48571542
122RPS6KL10.48571542
123MAPKAPK50.47450841
124MOS0.46875366
125LRRK20.46303283
126LATS20.45819218
127PDK10.45584815
128PRKCE0.44174115
129MAP3K60.44009225
130CAMK2G0.43574588
131ERBB20.41125617
132JAK30.40870492
133MAPK130.40309018
134MAPK40.40146372
135TYRO30.39864163
136FES0.38860596
137LATS10.38706706
138TAOK10.38621352
139DAPK30.36898669
140PAK40.36381111
141RPS6KA60.35188686
142FGFR10.35066883
143PRKCG0.34968665
144MAPKAPK20.33008233
145PRKCI0.32752354
146PRKCD0.31801908
147MAPK70.31281882
148TAOK20.30447100
149TYK20.30283002
150SRC0.30094674
151MAP3K140.25554668
152KIT0.25524638
153CDK80.25434856
154ADRBK10.23504490
155PRKAA10.21689278

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.61307231
2Phenylalanine metabolism_Homo sapiens_hsa003602.98649645
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76528552
4Insulin secretion_Homo sapiens_hsa049112.51885678
5Histidine metabolism_Homo sapiens_hsa003402.50663841
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37977481
7Tyrosine metabolism_Homo sapiens_hsa003502.31855431
8Circadian entrainment_Homo sapiens_hsa047132.20195635
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19865771
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06349447
11Glutathione metabolism_Homo sapiens_hsa004802.03899844
12Chemical carcinogenesis_Homo sapiens_hsa052042.02429799
13Synaptic vesicle cycle_Homo sapiens_hsa047211.98948824
14Pentose phosphate pathway_Homo sapiens_hsa000301.86103929
15Notch signaling pathway_Homo sapiens_hsa043301.85945900
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85877199
17Amphetamine addiction_Homo sapiens_hsa050311.85706020
18Olfactory transduction_Homo sapiens_hsa047401.80482567
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79340745
20GABAergic synapse_Homo sapiens_hsa047271.72650176
21Gastric acid secretion_Homo sapiens_hsa049711.72483508
22Type II diabetes mellitus_Homo sapiens_hsa049301.67385524
23Long-term potentiation_Homo sapiens_hsa047201.66516338
24Morphine addiction_Homo sapiens_hsa050321.60327135
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59308129
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57097842
27Fructose and mannose metabolism_Homo sapiens_hsa000511.56538753
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55976057
29Salivary secretion_Homo sapiens_hsa049701.55188577
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53189734
31Taste transduction_Homo sapiens_hsa047421.50082851
32Glutamatergic synapse_Homo sapiens_hsa047241.50011049
33Cocaine addiction_Homo sapiens_hsa050301.46304741
34Dopaminergic synapse_Homo sapiens_hsa047281.45210672
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.44674733
36Cholinergic synapse_Homo sapiens_hsa047251.44435594
37beta-Alanine metabolism_Homo sapiens_hsa004101.44415888
38Renin secretion_Homo sapiens_hsa049241.43952765
39Dilated cardiomyopathy_Homo sapiens_hsa054141.43726625
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42359906
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38042857
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35452091
43Oxytocin signaling pathway_Homo sapiens_hsa049211.34799141
44cAMP signaling pathway_Homo sapiens_hsa040241.34770715
45Sphingolipid metabolism_Homo sapiens_hsa006001.31154470
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.28870084
47Nicotine addiction_Homo sapiens_hsa050331.27830251
48Calcium signaling pathway_Homo sapiens_hsa040201.27194366
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25367339
50GnRH signaling pathway_Homo sapiens_hsa049121.23885072
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.20366265
52Thyroid hormone synthesis_Homo sapiens_hsa049181.20273621
53Vibrio cholerae infection_Homo sapiens_hsa051101.19743492
54Estrogen signaling pathway_Homo sapiens_hsa049151.19267086
55Arachidonic acid metabolism_Homo sapiens_hsa005901.18194832
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18181530
57Pancreatic secretion_Homo sapiens_hsa049721.17101899
58Galactose metabolism_Homo sapiens_hsa000521.15652663
59Tight junction_Homo sapiens_hsa045301.13171266
60Glucagon signaling pathway_Homo sapiens_hsa049221.13064700
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05531450
62Gap junction_Homo sapiens_hsa045401.04343488
63Circadian rhythm_Homo sapiens_hsa047101.02779737
64Insulin resistance_Homo sapiens_hsa049311.02604136
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00206072
66Sulfur relay system_Homo sapiens_hsa041220.98563735
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98525343
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94931070
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92140044
70ABC transporters_Homo sapiens_hsa020100.92086938
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91803973
72Focal adhesion_Homo sapiens_hsa045100.91547297
73Melanogenesis_Homo sapiens_hsa049160.91458945
74Protein digestion and absorption_Homo sapiens_hsa049740.90768863
75Insulin signaling pathway_Homo sapiens_hsa049100.89147590
76Glioma_Homo sapiens_hsa052140.88865810
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.88851180
78Cardiac muscle contraction_Homo sapiens_hsa042600.88795989
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87772354
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.87346187
81ECM-receptor interaction_Homo sapiens_hsa045120.85230546
82Serotonergic synapse_Homo sapiens_hsa047260.85047511
83Basal cell carcinoma_Homo sapiens_hsa052170.84940653
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84552405
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.81721744
86ErbB signaling pathway_Homo sapiens_hsa040120.81408812
87Lysosome_Homo sapiens_hsa041420.80731899
88N-Glycan biosynthesis_Homo sapiens_hsa005100.80641019
89Other glycan degradation_Homo sapiens_hsa005110.80011025
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79340782
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.79058468
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78472305
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77664795
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77516026
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.76236632
96PPAR signaling pathway_Homo sapiens_hsa033200.76186105
97Platelet activation_Homo sapiens_hsa046110.75677504
98VEGF signaling pathway_Homo sapiens_hsa043700.75424616
99Long-term depression_Homo sapiens_hsa047300.75283164
100Retinol metabolism_Homo sapiens_hsa008300.74926766
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74740518
102Complement and coagulation cascades_Homo sapiens_hsa046100.71175237
103Dorso-ventral axis formation_Homo sapiens_hsa043200.70043827
104Fatty acid degradation_Homo sapiens_hsa000710.69901510
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68715001
106Hedgehog signaling pathway_Homo sapiens_hsa043400.66860612
107Rap1 signaling pathway_Homo sapiens_hsa040150.66685050
108Prolactin signaling pathway_Homo sapiens_hsa049170.66603798
109Folate biosynthesis_Homo sapiens_hsa007900.65850317
110Adherens junction_Homo sapiens_hsa045200.65787681
111Hepatitis C_Homo sapiens_hsa051600.63821891
112Collecting duct acid secretion_Homo sapiens_hsa049660.63649469
113Choline metabolism in cancer_Homo sapiens_hsa052310.61943516
114AMPK signaling pathway_Homo sapiens_hsa041520.61917334
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61626738
116mTOR signaling pathway_Homo sapiens_hsa041500.59348528
117Proteoglycans in cancer_Homo sapiens_hsa052050.59286377
118Ovarian steroidogenesis_Homo sapiens_hsa049130.58394223
119MAPK signaling pathway_Homo sapiens_hsa040100.56468492
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55435306
121Hippo signaling pathway_Homo sapiens_hsa043900.54874390
122Peroxisome_Homo sapiens_hsa041460.54130576
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.54122406
124Bladder cancer_Homo sapiens_hsa052190.53969217
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.51914074
126Ras signaling pathway_Homo sapiens_hsa040140.51777339
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.50222812
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49722294
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49489629
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48755509
131Endometrial cancer_Homo sapiens_hsa052130.48539439
132Endocytosis_Homo sapiens_hsa041440.45884055
133Amoebiasis_Homo sapiens_hsa051460.45861337
134Prion diseases_Homo sapiens_hsa050200.45410890
135Non-small cell lung cancer_Homo sapiens_hsa052230.45329474
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44242181
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44139802
138Wnt signaling pathway_Homo sapiens_hsa043100.44005298
139Axon guidance_Homo sapiens_hsa043600.43374325
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42975764
141Salmonella infection_Homo sapiens_hsa051320.42240651
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42208955
143Linoleic acid metabolism_Homo sapiens_hsa005910.42133829
144Malaria_Homo sapiens_hsa051440.41128261
145Small cell lung cancer_Homo sapiens_hsa052220.38902411
146Pancreatic cancer_Homo sapiens_hsa052120.38328877
147TNF signaling pathway_Homo sapiens_hsa046680.38251079
148Huntingtons disease_Homo sapiens_hsa050160.34781147

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