ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	6.16068233
2	axonemal dynein complex assembly (GO:0070286)	5.96123996
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.85772705
4	synaptic vesicle maturation (GO:0016188)	5.56761379
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.46101136
6	cilium movement (GO:0003341)	5.21064550
7	glutamate secretion (GO:0014047)	5.18932584
8	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.09969307
9	synaptic vesicle exocytosis (GO:0016079)	4.78480364
10	regulation of synaptic vesicle exocytosis (GO:2000300)	4.76313602
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.71648088
12	locomotory exploration behavior (GO:0035641)	4.58849212
13	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.42188575
14	epithelial cilium movement (GO:0003351)	4.38525476
15	motile cilium assembly (GO:0044458)	4.36027935
16	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.30182121
17	axoneme assembly (GO:0035082)	4.26357584
18	axon ensheathment in central nervous system (GO:0032291)	4.22066819
19	central nervous system myelination (GO:0022010)	4.22066819
20	regulation of synaptic vesicle transport (GO:1902803)	4.14106583
21	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.12687948
22	neurotransmitter secretion (GO:0007269)	4.02877229
23	vocalization behavior (GO:0071625)	4.00549473
24	dendritic spine morphogenesis (GO:0060997)	3.93386828
25	neuronal ion channel clustering (GO:0045161)	3.93329655
26	synaptic transmission, glutamatergic (GO:0035249)	3.86031704
27	exploration behavior (GO:0035640)	3.85820257
28	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.84648025
29	L-amino acid import (GO:0043092)	3.71129029
30	regulation of synapse structural plasticity (GO:0051823)	3.56038984
31	cerebellar granule cell differentiation (GO:0021707)	3.50209570
32	gamma-aminobutyric acid transport (GO:0015812)	3.48957762
33	regulation of neuronal synaptic plasticity (GO:0048168)	3.48618769
34	presynaptic membrane organization (GO:0097090)	3.46715036
35	cellular potassium ion homeostasis (GO:0030007)	3.45889457
36	regulation of vesicle fusion (GO:0031338)	3.45494755
37	neurotransmitter-gated ion channel clustering (GO:0072578)	3.44725652
38	microtubule bundle formation (GO:0001578)	3.42755016
39	postsynaptic membrane organization (GO:0001941)	3.41564443
40	neuron cell-cell adhesion (GO:0007158)	3.36198307
41	neuron-neuron synaptic transmission (GO:0007270)	3.35059132
42	glutamate receptor signaling pathway (GO:0007215)	3.33862653
43	establishment of mitochondrion localization (GO:0051654)	3.32904706
44	amino acid import (GO:0043090)	3.31067676
45	neuronal action potential propagation (GO:0019227)	3.29464281
46	regulation of voltage-gated calcium channel activity (GO:1901385)	3.29215242
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.27835681
48	regulation of glutamate receptor signaling pathway (GO:1900449)	3.27231497
49	pyrimidine nucleobase catabolic process (GO:0006208)	3.26158206
50	neurotransmitter transport (GO:0006836)	3.22551060
51	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.22129613
52	regulation of cilium movement (GO:0003352)	3.21823546
53	protein localization to synapse (GO:0035418)	3.21529792
54	positive regulation of synapse maturation (GO:0090129)	3.21421500
55	sodium ion export (GO:0071436)	3.19576761
56	regulation of neurotransmitter secretion (GO:0046928)	3.19224382
57	positive regulation of membrane potential (GO:0045838)	3.14900656
58	regulation of neurotransmitter levels (GO:0001505)	3.12494443
59	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.11538738
60	potassium ion homeostasis (GO:0055075)	3.07646707
61	positive regulation of dendritic spine development (GO:0060999)	3.06677812
62	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.06063698
63	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.02806915
64	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.02702259
65	membrane depolarization during action potential (GO:0086010)	3.01903165
66	transmission of nerve impulse (GO:0019226)	3.01056787
67	auditory behavior (GO:0031223)	3.00967552
68	regulation of dendritic spine morphogenesis (GO:0061001)	2.97652472
69	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.96821488
70	presynaptic membrane assembly (GO:0097105)	2.96460915
71	retinal cone cell development (GO:0046549)	2.95569280
72	axonal fasciculation (GO:0007413)	2.95143685
73	neuron recognition (GO:0008038)	2.94879241
74	regulation of neurotransmitter transport (GO:0051588)	2.92981957
75	regulation of postsynaptic membrane potential (GO:0060078)	2.92809822
76	cerebellar Purkinje cell differentiation (GO:0021702)	2.91798873
77	dendritic spine organization (GO:0097061)	2.89191332
78	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.87851901
79	positive regulation of neurotransmitter transport (GO:0051590)	2.86834454
80	positive regulation of neurotransmitter secretion (GO:0001956)	2.86194468
81	cell migration in hindbrain (GO:0021535)	2.83860340
82	nucleobase catabolic process (GO:0046113)	2.82487120
83	membrane hyperpolarization (GO:0060081)	2.80397257
84	left/right pattern formation (GO:0060972)	2.80038640
85	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.79680936
86	mitochondrion transport along microtubule (GO:0047497)	2.79680936
87	regulation of microtubule-based movement (GO:0060632)	2.78092443
88	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.77414034
89	regulation of synaptic plasticity (GO:0048167)	2.76947972
90	ventricular system development (GO:0021591)	2.73398850
91	synaptic vesicle endocytosis (GO:0048488)	2.72538396
92	potassium ion import (GO:0010107)	2.71887688
93	cellular sodium ion homeostasis (GO:0006883)	2.71182624
94	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.66992528
95	neuromuscular synaptic transmission (GO:0007274)	2.66916380
96	regulation of dendritic spine development (GO:0060998)	2.64949879
97	membrane depolarization (GO:0051899)	2.64587491
98	regulation of synapse maturation (GO:0090128)	2.62170098
99	brain morphogenesis (GO:0048854)	2.61154661
100	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.60055084

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.85010110
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.43599219
3	DROSHA_22980978_ChIP-Seq_HELA_Human	3.10673528
4	REST_21632747_ChIP-Seq_MESCs_Mouse	2.78002948
5	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.49595959
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.37331717
7	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.35373453
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.34813525
9	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.33056169
10	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.29832845
11	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.27271628
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.22776810
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.22305535
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.14508964
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.14507206
16	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.13768421
17	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.11431910
18	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.10735476
19	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.04911384
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.04446567
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.04446567
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.00883301
23	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.99596181
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.92527889
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90615909
26	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.89630663
27	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.81044401
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.79349837
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.75013462
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.60552889
31	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.59443303
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.58146547
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48963348
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47198148
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45863651
36	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.45327587
37	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.39217482
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38233371
39	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.35421626
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.33944312
41	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.32317841
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31369112
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30957276
44	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30481768
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28656087
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25344174
47	AR_19668381_ChIP-Seq_PC3_Human	1.23765981
48	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.21668483
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21069386
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18688985
51	CTCF_27219007_Chip-Seq_Bcells_Human	1.15148449
52	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.14720587
53	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12407580
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11280557
55	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.11258303
56	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.10554659
57	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.09579435
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09231503
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08458791
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08047946
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07832060
62	STAT3_23295773_ChIP-Seq_U87_Human	1.06639635
63	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.05855054
64	KDM2B_26808549_Chip-Seq_K562_Human	1.05193025
65	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04971188
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03127134
67	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.03006135
68	IGF1R_20145208_ChIP-Seq_DFB_Human	1.02161367
69	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.01764509
70	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99247933
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98964283
72	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.98926251
73	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.98838582
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98381465
75	TCF4_23295773_ChIP-Seq_U87_Human	0.97797138
76	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97598639
77	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96838048
78	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.95451019
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.94007030
80	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93758547
81	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93686760
82	AHR_22903824_ChIP-Seq_MCF-7_Human	0.93251293
83	AR_25329375_ChIP-Seq_VCAP_Human	0.92686595
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92386630
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92113857
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92059013
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92059013
88	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.92044663
89	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.90311826
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.89888078
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.89723128
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.88652965
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88187674
94	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.87569260
95	P300_19829295_ChIP-Seq_ESCs_Human	0.87321408
96	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.86496610
97	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.85749893
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.82309949
99	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.81634188
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.80513830

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	5.14566240
2	MP0003880_abnormal_central_pattern	4.11876449
3	MP0004270_analgesia	3.91598853
4	MP0003635_abnormal_synaptic_transmissio	3.41706197
5	MP0005423_abnormal_somatic_nervous	3.23785603
6	MP0002064_seizures	3.07112739
7	MP0009745_abnormal_behavioral_response	2.93922729
8	MP0009046_muscle_twitch	2.86084587
9	MP0002063_abnormal_learning/memory/cond	2.81110131
10	MP0002272_abnormal_nervous_system	2.78915092
11	MP0001486_abnormal_startle_reflex	2.74671275
12	MP0002734_abnormal_mechanical_nocicepti	2.61640284
13	MP0002572_abnormal_emotion/affect_behav	2.44219912
14	MP0001984_abnormal_olfaction	2.43066830
15	MP0001968_abnormal_touch/_nociception	2.31918767
16	MP0002653_abnormal_ependyma_morphology	2.23884676
17	MP0002735_abnormal_chemical_nociception	2.15069082
18	MP0000778_abnormal_nervous_system	2.11496752
19	MP0009780_abnormal_chondrocyte_physiolo	2.11189137
20	MP0001970_abnormal_pain_threshold	1.99324408
21	MP0002822_catalepsy	1.94604174
22	MP0003787_abnormal_imprinting	1.94042871
23	MP0003879_abnormal_hair_cell	1.93069513
24	MP0006276_abnormal_autonomic_nervous	1.89454473
25	MP0008569_lethality_at_weaning	1.86789406
26	MP0004885_abnormal_endolymph	1.82261489
27	MP0002733_abnormal_thermal_nociception	1.79752344
28	MP0002557_abnormal_social/conspecific_i	1.79739118
29	MP0001501_abnormal_sleep_pattern	1.77122574
30	MP0000955_abnormal_spinal_cord	1.74210918
31	MP0003329_amyloid_beta_deposits	1.73023424
32	MP0001440_abnormal_grooming_behavior	1.67533069
33	MP0002736_abnormal_nociception_after	1.67072647
34	MP0002067_abnormal_sensory_capabilities	1.66181687
35	MP0001188_hyperpigmentation	1.62625347
36	MP0001502_abnormal_circadian_rhythm	1.61225637
37	MP0002882_abnormal_neuron_morphology	1.59257274
38	MP0004811_abnormal_neuron_physiology	1.57213585
39	MP0005646_abnormal_pituitary_gland	1.56426260
40	MP0003122_maternal_imprinting	1.47189923
41	MP0003690_abnormal_glial_cell	1.44388963
42	MP0002066_abnormal_motor_capabilities/c	1.41884100
43	MP0003633_abnormal_nervous_system	1.41220259
44	MP0002184_abnormal_innervation	1.36015689
45	MP0005386_behavior/neurological_phenoty	1.35286639
46	MP0004924_abnormal_behavior	1.35286639
47	MP0002909_abnormal_adrenal_gland	1.31508618
48	MP0002229_neurodegeneration	1.30401949
49	MP0004742_abnormal_vestibular_system	1.29148606
50	MP0000920_abnormal_myelination	1.27437440
51	MP0005551_abnormal_eye_electrophysiolog	1.27309294
52	MP0002638_abnormal_pupillary_reflex	1.24116236
53	MP0001905_abnormal_dopamine_level	1.20699214
54	MP0001485_abnormal_pinna_reflex	1.18375945
55	MP0003631_nervous_system_phenotype	1.17343766
56	MP0001529_abnormal_vocalization	1.14074734
57	MP0004142_abnormal_muscle_tone	1.14047121
58	MP0004043_abnormal_pH_regulation	1.12915996
59	MP0002152_abnormal_brain_morphology	1.11540086
60	MP0004133_heterotaxia	1.10970998
61	MP0001963_abnormal_hearing_physiology	1.06768617
62	MP0005623_abnormal_meninges_morphology	1.03972855
63	MP0001986_abnormal_taste_sensitivity	1.03443777
64	MP0003123_paternal_imprinting	1.01678198
65	MP0005394_taste/olfaction_phenotype	1.01148272
66	MP0005499_abnormal_olfactory_system	1.01148272
67	MP0002752_abnormal_somatic_nervous	0.99309796
68	MP0004145_abnormal_muscle_electrophysio	0.93439363
69	MP0003634_abnormal_glial_cell	0.93056806
70	MP0000566_synostosis	0.90294207
71	MP0004130_abnormal_muscle_cell	0.89308900
72	MP0003632_abnormal_nervous_system	0.88474898
73	MP0001177_atelectasis	0.88362520
74	MP0001346_abnormal_lacrimal_gland	0.87599254
75	MP0002069_abnormal_eating/drinking_beha	0.87412359
76	MP0000631_abnormal_neuroendocrine_gland	0.85427793
77	MP0008875_abnormal_xenobiotic_pharmacok	0.82518394
78	MP0008789_abnormal_olfactory_epithelium	0.79286621
79	MP0005253_abnormal_eye_physiology	0.77465100
80	MP0003136_yellow_coat_color	0.76840133
81	MP0000026_abnormal_inner_ear	0.76099628
82	MP0000751_myopathy	0.73604046
83	MP0003861_abnormal_nervous_system	0.72734761
84	MP0002876_abnormal_thyroid_physiology	0.70059379
85	MP0005645_abnormal_hypothalamus_physiol	0.70041979
86	MP0005535_abnormal_body_temperature	0.68891147
87	MP0004085_abnormal_heartbeat	0.68888506
88	MP0002249_abnormal_larynx_morphology	0.68501928
89	MP0003121_genomic_imprinting	0.65335572
90	MP0003137_abnormal_impulse_conducting	0.63986793
91	MP0001299_abnormal_eye_distance/	0.63924915
92	MP0003938_abnormal_ear_development	0.62595054
93	MP0005409_darkened_coat_color	0.62317114
94	MP0002160_abnormal_reproductive_system	0.61794047
95	MP0001943_abnormal_respiration	0.60404523
96	MP0000604_amyloidosis	0.58351207
97	MP0008874_decreased_physiological_sensi	0.58135867
98	MP0010769_abnormal_survival	0.56948675
99	MP0010770_preweaning_lethality	0.56774040
100	MP0002082_postnatal_lethality	0.56774040

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.94754824
2	Absent/shortened dynein arms (HP:0200106)	6.94754824
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.81967847
4	Abnormal ciliary motility (HP:0012262)	6.30803063
5	Abnormal respiratory epithelium morphology (HP:0012253)	6.30798473
6	Abnormal respiratory motile cilium morphology (HP:0005938)	6.30798473
7	Abnormal respiratory motile cilium physiology (HP:0012261)	6.03083402
8	Myokymia (HP:0002411)	5.37496946
9	Rhinitis (HP:0012384)	5.04336308
10	Focal motor seizures (HP:0011153)	4.41622980
11	Focal seizures (HP:0007359)	4.17438824
12	Chronic bronchitis (HP:0004469)	3.77701654
13	Epileptic encephalopathy (HP:0200134)	3.70824576
14	Action tremor (HP:0002345)	3.56027496
15	Febrile seizures (HP:0002373)	3.49806233
16	Bronchiectasis (HP:0002110)	3.41839151
17	Ankle clonus (HP:0011448)	3.31091543
18	Atonic seizures (HP:0010819)	3.23687340
19	Progressive cerebellar ataxia (HP:0002073)	3.15334574
20	Supranuclear gaze palsy (HP:0000605)	3.14960982
21	Nasal polyposis (HP:0100582)	2.96146873
22	Spastic gait (HP:0002064)	2.91076905
23	Limb dystonia (HP:0002451)	2.90632300
24	Gait imbalance (HP:0002141)	2.80673207
25	Generalized tonic-clonic seizures (HP:0002069)	2.64466298
26	Abnormal eating behavior (HP:0100738)	2.63569506
27	Epileptiform EEG discharges (HP:0011182)	2.54768885
28	Polyphagia (HP:0002591)	2.53735830
29	Papilledema (HP:0001085)	2.49280449
30	Medial flaring of the eyebrow (HP:0010747)	2.43925502
31	Fetal akinesia sequence (HP:0001989)	2.43537870
32	Diplopia (HP:0000651)	2.42692656
33	Abnormality of binocular vision (HP:0011514)	2.42692656
34	Abnormality of the corticospinal tract (HP:0002492)	2.42643193
35	Torticollis (HP:0000473)	2.39023049
36	EEG with generalized epileptiform discharges (HP:0011198)	2.37265668
37	Infertility (HP:0000789)	2.36408250
38	Obstructive sleep apnea (HP:0002870)	2.34927729
39	Neurofibrillary tangles (HP:0002185)	2.34697907
40	Absence seizures (HP:0002121)	2.33427929
41	Urinary bladder sphincter dysfunction (HP:0002839)	2.32146244
42	Hypsarrhythmia (HP:0002521)	2.31877004
43	Broad-based gait (HP:0002136)	2.30181104
44	Abnormality of the nasal mucosa (HP:0000433)	2.29103868
45	Tubulointerstitial nephritis (HP:0001970)	2.28415987
46	Sleep apnea (HP:0010535)	2.28363469
47	Dialeptic seizures (HP:0011146)	2.27631837
48	Nephronophthisis (HP:0000090)	2.27405190
49	Intention tremor (HP:0002080)	2.26255080
50	Peripheral hypomyelination (HP:0007182)	2.24366527
51	Chronic hepatic failure (HP:0100626)	2.24169369
52	Hyperventilation (HP:0002883)	2.23941662
53	Dysdiadochokinesis (HP:0002075)	2.23903591
54	Congenital primary aphakia (HP:0007707)	2.21162785
55	Dysmetria (HP:0001310)	2.19726678
56	Postural instability (HP:0002172)	2.19427721
57	Pancreatic fibrosis (HP:0100732)	2.18498569
58	Urinary urgency (HP:0000012)	2.15636733
59	Cystic liver disease (HP:0006706)	2.14978869
60	Occipital encephalocele (HP:0002085)	2.14112582
61	Prolonged QT interval (HP:0001657)	2.13429517
62	Status epilepticus (HP:0002133)	2.12167721
63	Impaired vibration sensation in the lower limbs (HP:0002166)	2.11704361
64	Amblyopia (HP:0000646)	2.11185709
65	Nephrogenic diabetes insipidus (HP:0009806)	2.10234358
66	True hermaphroditism (HP:0010459)	2.09614856
67	Visual hallucinations (HP:0002367)	2.05971791
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05617883
69	Akinesia (HP:0002304)	2.05308932
70	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.05108170
71	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.05108170
72	Truncal ataxia (HP:0002078)	2.04918844
73	Absent speech (HP:0001344)	2.00471466
74	Bell-shaped thorax (HP:0001591)	1.98904813
75	Depression (HP:0000716)	1.97128393
76	Abnormality of midbrain morphology (HP:0002418)	1.96655845
77	Molar tooth sign on MRI (HP:0002419)	1.96655845
78	Lower limb muscle weakness (HP:0007340)	1.94681554
79	Focal dystonia (HP:0004373)	1.92947156
80	Drooling (HP:0002307)	1.91492570
81	Abnormal hair whorl (HP:0010721)	1.88817863
82	Bronchitis (HP:0012387)	1.86325761
83	Scanning speech (HP:0002168)	1.86202040
84	Specific learning disability (HP:0001328)	1.85886631
85	Pancreatic cysts (HP:0001737)	1.82505021
86	Anxiety (HP:0000739)	1.82326759
87	Abnormality of the renal medulla (HP:0100957)	1.82302218
88	Vaginal atresia (HP:0000148)	1.82134843
89	Gaze-evoked nystagmus (HP:0000640)	1.81915510
90	Recurrent otitis media (HP:0000403)	1.80358868
91	Genetic anticipation (HP:0003743)	1.79094921
92	Genital tract atresia (HP:0001827)	1.78914401
93	Hemiparesis (HP:0001269)	1.78449113
94	Poor eye contact (HP:0000817)	1.77547848
95	Excessive salivation (HP:0003781)	1.75047481
96	Cerebral inclusion bodies (HP:0100314)	1.74194949
97	Abnormality of the lower motor neuron (HP:0002366)	1.73637763
98	Atelectasis (HP:0100750)	1.73382823
99	Chronic sinusitis (HP:0011109)	1.71670265
100	Craniofacial dystonia (HP:0012179)	1.71199187

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.39677240
2	EPHA4	3.68862370
3	NTRK3	3.43507545
4	CASK	2.87788249
5	PAK6	2.62766967
6	MAPK15	2.60966863
7	DAPK2	2.55700126
8	UHMK1	2.49253850
9	NTRK2	2.29774962
10	PINK1	2.16395081
11	MAP3K9	2.15345515
12	CAMKK1	2.11661144
13	MINK1	2.08945502
14	MAP3K4	2.01628076
15	SIK2	1.89478088
16	MAPK13	1.83534343
17	PRKD3	1.77760869
18	PHKG2	1.77679376
19	PHKG1	1.77679376
20	PAK3	1.64524854
21	SGK494	1.59100357
22	SGK223	1.59100357
23	CDK5	1.51077654
24	MAP2K7	1.42653623
25	BCR	1.38735063
26	MARK2	1.32266738
27	NTRK1	1.30077023
28	PRKCG	1.28188981
29	DYRK1A	1.23073731
30	MAP2K4	1.20415605
31	CAMK1	1.19049112
32	FGFR2	1.14612424
33	MUSK	1.13788442
34	SGK2	1.13199634
35	BMPR1B	1.07199433
36	FRK	1.06583111
37	CAMKK2	1.06153347
38	CAMK2B	1.06020626
39	ARAF	1.05592863
40	CDK19	1.05036922
41	PLK2	1.01855372
42	CAMK2A	1.00118085
43	STK11	0.98722631
44	PRKCH	0.95667189
45	TYRO3	0.94561372
46	OXSR1	0.92968312
47	PKN1	0.92759988
48	TNIK	0.88302798
49	CAMK1G	0.87868248
50	STK38	0.87209011
51	DYRK2	0.87161029
52	CAMK2G	0.84521518
53	SGK1	0.84244527
54	SGK3	0.83283901
55	CSNK1G2	0.81648088
56	GRK5	0.78681301
57	MAPK12	0.75117815
58	ERBB2	0.72103209
59	PRKCZ	0.71550262
60	CAMK4	0.69291421
61	CDK15	0.66410077
62	CDK14	0.65775159
63	CDK18	0.65235956
64	CAMK1D	0.64660790
65	TNK2	0.62014798
66	RPS6KA3	0.61848680
67	CAMK2D	0.61426388
68	MAPK10	0.61284058
69	CDK11A	0.61242625
70	MAP3K7	0.61184252
71	WNK3	0.60154192
72	PNCK	0.57548516
73	ROCK2	0.55785558
74	NEK6	0.55607950
75	DYRK1B	0.55475511
76	RIPK1	0.54111023
77	PRKCE	0.51588603
78	KSR2	0.51400154
79	FYN	0.50797399
80	LATS2	0.50566528
81	STK39	0.49394838
82	INSRR	0.49137565
83	AKT3	0.48859247
84	PRKACA	0.46933597
85	PRKG1	0.45309275
86	CSNK1A1L	0.45280975
87	MAP3K13	0.45090852
88	PRKAA1	0.43237213
89	PRKD1	0.42036080
90	DAPK1	0.41581919
91	PDK1	0.39746043
92	ERBB3	0.39635844
93	WNK1	0.38875801
94	BRAF	0.38636694
95	PRKCA	0.37979392
96	CSNK1G3	0.36738025
97	MAP3K6	0.36678851
98	PDPK1	0.36564409
99	CSNK1E	0.36180684
100	KSR1	0.36178595

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.94419901
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.09442749
3	Glutamatergic synapse_Homo sapiens_hsa04724	2.52689910
4	Circadian entrainment_Homo sapiens_hsa04713	2.52620622
5	GABAergic synapse_Homo sapiens_hsa04727	2.49370942
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.46444248
7	Amphetamine addiction_Homo sapiens_hsa05031	2.40387488
8	Insulin secretion_Homo sapiens_hsa04911	2.32811875
9	Morphine addiction_Homo sapiens_hsa05032	2.30714410
10	Long-term potentiation_Homo sapiens_hsa04720	2.12596886
11	Dopaminergic synapse_Homo sapiens_hsa04728	2.07245168
12	Cocaine addiction_Homo sapiens_hsa05030	2.03460969
13	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.93497740
14	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.74141682
15	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.67311407
16	Gastric acid secretion_Homo sapiens_hsa04971	1.65436644
17	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.62749958
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.56169450
19	Cholinergic synapse_Homo sapiens_hsa04725	1.55800067
20	Salivary secretion_Homo sapiens_hsa04970	1.55239200
21	Histidine metabolism_Homo sapiens_hsa00340	1.51679003
22	Long-term depression_Homo sapiens_hsa04730	1.49350066
23	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.45581121
24	Renin secretion_Homo sapiens_hsa04924	1.43722260
25	Taste transduction_Homo sapiens_hsa04742	1.42532919
26	Serotonergic synapse_Homo sapiens_hsa04726	1.38455104
27	cAMP signaling pathway_Homo sapiens_hsa04024	1.32919689
28	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.32824014
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28724953
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.26987602
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20595486
32	Axon guidance_Homo sapiens_hsa04360	1.15666312
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13273138
34	Phototransduction_Homo sapiens_hsa04744	1.06740799
35	Circadian rhythm_Homo sapiens_hsa04710	1.04552824
36	Olfactory transduction_Homo sapiens_hsa04740	1.03646269
37	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.02966835
38	Type II diabetes mellitus_Homo sapiens_hsa04930	1.02922968
39	GnRH signaling pathway_Homo sapiens_hsa04912	1.02676566
40	Bile secretion_Homo sapiens_hsa04976	0.96974796
41	Phenylalanine metabolism_Homo sapiens_hsa00360	0.96274286
42	Gap junction_Homo sapiens_hsa04540	0.91837880
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.87150910
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85580571
45	Melanogenesis_Homo sapiens_hsa04916	0.85393092
46	ABC transporters_Homo sapiens_hsa02010	0.85249389
47	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.85020289
48	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.83536182
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.83398195
50	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.83078299
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.82941860
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81196170
53	Butanoate metabolism_Homo sapiens_hsa00650	0.81059001
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78985816
55	Pancreatic secretion_Homo sapiens_hsa04972	0.76935033
56	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74982584
57	Glucagon signaling pathway_Homo sapiens_hsa04922	0.72376259
58	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.70943587
59	ErbB signaling pathway_Homo sapiens_hsa04012	0.69798048
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69686814
61	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68494949
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66545367
63	Tight junction_Homo sapiens_hsa04530	0.64152350
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63441326
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.62931105
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62150434
67	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.61837838
68	Ras signaling pathway_Homo sapiens_hsa04014	0.60367330
69	Choline metabolism in cancer_Homo sapiens_hsa05231	0.56466863
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.56443363
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54931384
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.54909326
73	Huntingtons disease_Homo sapiens_hsa05016	0.53827139
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53579830
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52433429
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.51832236
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50897093
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.49899475
79	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.48904373
80	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.47702619
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.47265271
82	Glioma_Homo sapiens_hsa05214	0.46565847
83	Regulation of autophagy_Homo sapiens_hsa04140	0.46041406
84	Oocyte meiosis_Homo sapiens_hsa04114	0.45389740
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45149346
86	Insulin signaling pathway_Homo sapiens_hsa04910	0.44778565
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44608588
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.43616262
89	Mineral absorption_Homo sapiens_hsa04978	0.42170174
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41184767
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39717858
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39333163
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.38992410
94	Endocytosis_Homo sapiens_hsa04144	0.38080606
95	Prion diseases_Homo sapiens_hsa05020	0.37814484
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37779970
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37385409
98	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36969603
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.36810844
100	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35843413

ZDHHC11B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »