ZDHHC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.69611501
2formation of translation preinitiation complex (GO:0001731)4.62405887
3ribosomal small subunit biogenesis (GO:0042274)4.43852687
4ribosomal small subunit assembly (GO:0000028)4.32629320
5maturation of SSU-rRNA (GO:0030490)4.23037854
6DNA strand elongation involved in DNA replication (GO:0006271)4.12665692
7viral transcription (GO:0019083)3.90995200
8telomere maintenance via semi-conservative replication (GO:0032201)3.89891068
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.88782692
10DNA strand elongation (GO:0022616)3.88021900
11translational termination (GO:0006415)3.79084692
12DNA replication initiation (GO:0006270)3.78117243
13protein maturation by protein folding (GO:0022417)3.76213707
14ribonucleoprotein complex biogenesis (GO:0022613)3.68990022
15rRNA modification (GO:0000154)3.66574674
16pyrimidine nucleoside salvage (GO:0043097)3.65515893
17pyrimidine-containing compound salvage (GO:0008655)3.65515893
18ribosome biogenesis (GO:0042254)3.60326951
19pseudouridine synthesis (GO:0001522)3.60291016
20nucleobase biosynthetic process (GO:0046112)3.59309305
21telomere maintenance via recombination (GO:0000722)3.54699143
22neutrophil activation involved in immune response (GO:0002283)3.54536073
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54433021
24proteasome assembly (GO:0043248)3.53340830
25translational elongation (GO:0006414)3.46843672
26cotranslational protein targeting to membrane (GO:0006613)3.46800015
27protein targeting to ER (GO:0045047)3.44697173
28DNA unwinding involved in DNA replication (GO:0006268)3.42217068
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38215362
30translational initiation (GO:0006413)3.37594644
31ribosomal large subunit biogenesis (GO:0042273)3.37426903
32purine nucleobase biosynthetic process (GO:0009113)3.35492080
33DNA replication checkpoint (GO:0000076)3.34256932
34establishment of integrated proviral latency (GO:0075713)3.31047765
35protein localization to endoplasmic reticulum (GO:0070972)3.27160304
36translation (GO:0006412)3.25312177
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24610601
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22862205
39cullin deneddylation (GO:0010388)3.22628875
40mitotic recombination (GO:0006312)3.19998899
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18978327
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18978327
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16194192
44negative regulation of ligase activity (GO:0051352)3.16194192
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15992220
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15992220
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15992220
48rRNA processing (GO:0006364)3.14979743
49protein deneddylation (GO:0000338)3.14555138
50folic acid-containing compound biosynthetic process (GO:0009396)3.13391660
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13077744
52DNA replication-dependent nucleosome assembly (GO:0006335)3.13039139
53DNA replication-dependent nucleosome organization (GO:0034723)3.13039139
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12206205
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11725006
56pentose metabolic process (GO:0019321)3.11398309
57spliceosomal snRNP assembly (GO:0000387)3.11065761
58rRNA methylation (GO:0031167)3.10212298
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.10181836
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10181836
61nucleotide salvage (GO:0043173)3.09520810
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08799569
63viral life cycle (GO:0019058)3.08466185
64termination of RNA polymerase III transcription (GO:0006386)3.08286816
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.08286816
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.05019267
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03604480
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03342487
69pteridine-containing compound biosynthetic process (GO:0042559)3.01254339
70rRNA metabolic process (GO:0016072)3.01057848
71GDP-mannose metabolic process (GO:0019673)3.00618105
72protein localization to kinetochore (GO:0034501)3.00591191
73regulation of cellular amino acid metabolic process (GO:0006521)3.00399195
74cellular component biogenesis (GO:0044085)2.99404355
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.99116031
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97259961
77folic acid metabolic process (GO:0046655)2.96425354
78pentose-phosphate shunt (GO:0006098)2.95115277
79cellular protein complex disassembly (GO:0043624)2.93887596
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.91314442
81Golgi transport vesicle coating (GO:0048200)2.86580462
82COPI coating of Golgi vesicle (GO:0048205)2.86580462
83response to peptidoglycan (GO:0032494)2.85297628
84telomere maintenance via telomere lengthening (GO:0010833)2.85108744
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84380144
86ribosome assembly (GO:0042255)2.82688893
87nucleoside salvage (GO:0043174)2.81688269
88deoxyribose phosphate biosynthetic process (GO:0046385)2.78436221
892-deoxyribonucleotide biosynthetic process (GO:0009265)2.78436221
90regulation of mitochondrial translation (GO:0070129)2.78139817
91transcription-coupled nucleotide-excision repair (GO:0006283)2.77152376
92pinocytosis (GO:0006907)2.76381694
93DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75268951
94oxidative phosphorylation (GO:0006119)2.73800184
95NADPH regeneration (GO:0006740)2.72568711
96guanosine-containing compound biosynthetic process (GO:1901070)2.72206330
97regulation of posttranscriptional gene silencing (GO:0060147)2.72116328
98regulation of gene silencing by miRNA (GO:0060964)2.72116328
99regulation of gene silencing by RNA (GO:0060966)2.72116328
100negative regulation of gene silencing (GO:0060969)2.71398772
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70853920
102autophagic vacuole fusion (GO:0000046)2.70241316
103negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.69944070
104transcription from mitochondrial promoter (GO:0006390)2.67439545
105protein complex disassembly (GO:0043241)2.67255592
106purine deoxyribonucleotide catabolic process (GO:0009155)2.66662438
107regulation of superoxide anion generation (GO:0032928)2.65802128
108positive regulation of cell cycle arrest (GO:0071158)2.64911092
109cell cycle G1/S phase transition (GO:0044843)2.64732744
110G1/S transition of mitotic cell cycle (GO:0000082)2.64732744
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61651536
112nucleobase-containing small molecule interconversion (GO:0015949)2.61507726
113transcription from RNA polymerase I promoter (GO:0006360)2.60242502
114macromolecular complex disassembly (GO:0032984)2.60191238
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59793378
116negative regulation of myeloid cell apoptotic process (GO:0033033)2.59682483
117mitotic nuclear envelope disassembly (GO:0007077)2.59671728
118IMP biosynthetic process (GO:0006188)2.59169958
119purine nucleotide salvage (GO:0032261)2.58326406
120protein localization to chromosome, centromeric region (GO:0071459)2.58270409
121antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.56754611
122heterochromatin organization (GO:0070828)2.56628721
123establishment of viral latency (GO:0019043)2.56234934
124L-methionine salvage (GO:0071267)2.54701051
125L-methionine biosynthetic process (GO:0071265)2.54701051
126amino acid salvage (GO:0043102)2.54701051
127deoxyribonucleotide catabolic process (GO:0009264)2.53187121
128deoxyribose phosphate catabolic process (GO:0046386)2.52866192
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50458824
130response to interferon-beta (GO:0035456)2.50121035
131glucose catabolic process (GO:0006007)2.50086108
132positive regulation of ligase activity (GO:0051351)2.47902286
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.46898692
134glycosphingolipid catabolic process (GO:0046479)2.45954941
135NIK/NF-kappaB signaling (GO:0038061)2.45869833
136regulation of cellular amine metabolic process (GO:0033238)2.45734899
137GMP metabolic process (GO:0046037)2.43067330
138immunoglobulin mediated immune response (GO:0016064)2.41587846
139negative regulation of B cell apoptotic process (GO:0002903)2.40964391
140proline biosynthetic process (GO:0006561)2.38890861
141negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.35729627
142deoxyribonucleotide biosynthetic process (GO:0009263)2.27668083
143mitochondrial calcium ion transport (GO:0006851)2.27349105
144cytochrome complex assembly (GO:0017004)2.27303466
145regulation of ubiquitin-protein transferase activity (GO:0051438)2.27200698
146mitotic nuclear envelope reassembly (GO:0007084)2.26512173
147nuclear envelope reassembly (GO:0031468)2.26512173
148protein targeting to mitochondrion (GO:0006626)2.26007593
149protein retention in ER lumen (GO:0006621)2.25817533
150glycolipid catabolic process (GO:0019377)2.25724519
151lipoxygenase pathway (GO:0019372)2.25552595
152chaperone-mediated protein transport (GO:0072321)2.24197402
153cellular metabolic compound salvage (GO:0043094)2.22772217
154regulation of ligase activity (GO:0051340)2.22707104
155organelle membrane fusion (GO:0090174)2.22464353
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.21983472
157energy coupled proton transport, down electrochemical gradient (GO:0015985)2.21564936
158ATP synthesis coupled proton transport (GO:0015986)2.21564936
159pyrimidine nucleoside biosynthetic process (GO:0046134)2.21560980
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.19244541
161chaperone mediated protein folding requiring cofactor (GO:0051085)2.18939789
162metallo-sulfur cluster assembly (GO:0031163)2.16658199
163iron-sulfur cluster assembly (GO:0016226)2.16658199
164G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.16090722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16143884
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.81910273
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56293011
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25744610
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11135950
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05234234
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94609981
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.94286849
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83501702
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.79344919
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62828731
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55988643
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55298479
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34618604
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32300104
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22256941
17E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18242111
18XRN2_22483619_ChIP-Seq_HELA_Human2.14934623
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13712479
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13023547
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05564186
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04648562
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99946660
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96963375
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96963375
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96963375
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94692144
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.94443119
29VDR_23849224_ChIP-Seq_CD4+_Human1.92106242
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.91843772
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.85001953
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83242029
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80820961
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79605234
35DCP1A_22483619_ChIP-Seq_HELA_Human1.78769408
36* GABP_19822575_ChIP-Seq_HepG2_Human1.77260377
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73180551
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71688744
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71532647
40FOXP3_21729870_ChIP-Seq_TREG_Human1.71271826
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70592456
42LXR_22292898_ChIP-Seq_THP-1_Human1.68361213
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.66232959
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60970227
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59960799
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57939607
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.56364975
48* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55878477
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53928454
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53715219
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53158152
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.52328124
53RACK7_27058665_Chip-Seq_MCF-7_Human1.48746316
54TTF2_22483619_ChIP-Seq_HELA_Human1.47704356
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47673299
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45985518
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44416586
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.42859229
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42008597
60VDR_24763502_ChIP-Seq_THP-1_Human1.41195810
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36782622
62ZNF263_19887448_ChIP-Seq_K562_Human1.36038216
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.30925479
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30658618
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29508158
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28575454
67BCL6_27268052_Chip-Seq_Bcells_Human1.28525744
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28522338
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27741567
70P68_20966046_ChIP-Seq_HELA_Human1.26063790
71MAF_26560356_Chip-Seq_TH1_Human1.25382931
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25359264
73AR_21909140_ChIP-Seq_LNCAP_Human1.24453248
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24317285
75ELK1_19687146_ChIP-ChIP_HELA_Human1.24150686
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.24107565
77BCOR_27268052_Chip-Seq_Bcells_Human1.23776803
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23580904
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23051238
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22922321
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21939057
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.21198720
83MAF_26560356_Chip-Seq_TH2_Human1.19796066
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18676497
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18571110
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18423010
87UTX_26944678_Chip-Seq_JUKART_Human1.18313989
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17815880
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15484215
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15236497
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14584067
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13528793
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.13513661
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12689848
95VDR_21846776_ChIP-Seq_THP-1_Human1.11648921
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11590101
97* CTCF_26484167_Chip-Seq_Bcells_Mouse1.11495941
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11471358
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11207825
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10743620
101KDM5A_27292631_Chip-Seq_BREAST_Human1.10357154
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08964395
103* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08891554
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08808352
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08186785
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.07327859
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.07192909
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07107286
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06318091
110TFEB_21752829_ChIP-Seq_HELA_Human1.06304520
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05629409
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.05621578
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05466987
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04824662
115ATF3_27146783_Chip-Seq_COLON_Human1.04568980
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04540869
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04178595
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04133331
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03509492
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02954889
121* CIITA_25753668_ChIP-Seq_RAJI_Human1.01624938
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01057461
123MYC_22102868_ChIP-Seq_BL_Human1.00308071
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99426607
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99415539
126SPI1_23547873_ChIP-Seq_NB4_Human0.98670977
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97685452
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97087645
129NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95552440
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.94136155
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92630910
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91359148
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87779511
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86320116
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85151353
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.84796231
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82962071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.64090704
2MP0003693_abnormal_embryo_hatching4.23367727
3MP0004957_abnormal_blastocyst_morpholog3.99253936
4MP0003191_abnormal_cellular_cholesterol3.12380854
5MP0008057_abnormal_DNA_replication3.10163183
6MP0008260_abnormal_autophagy2.98370920
7MP0003077_abnormal_cell_cycle2.86468013
8MP0003111_abnormal_nucleus_morphology2.78950293
9MP0010094_abnormal_chromosome_stability2.62357862
10MP0003186_abnormal_redox_activity2.45656867
11MP0008932_abnormal_embryonic_tissue2.43353583
12MP0003283_abnormal_digestive_organ2.36009111
13MP0005451_abnormal_body_composition2.27417479
14MP0008058_abnormal_DNA_repair2.21194697
15MP0010352_gastrointestinal_tract_polyps2.20086086
16MP0004264_abnormal_extraembryonic_tissu2.13442490
17MP0005464_abnormal_platelet_physiology2.08758911
18MP0008007_abnormal_cellular_replicative2.08302494
19MP0009333_abnormal_splenocyte_physiolog1.87820358
20MP0003303_peritoneal_inflammation1.82607735
21MP0004133_heterotaxia1.78498096
22MP0003315_abnormal_perineum_morphology1.76121066
23MP0005075_abnormal_melanosome_morpholog1.76011709
24MP0002877_abnormal_melanocyte_morpholog1.75443989
25MP0002419_abnormal_innate_immunity1.75068245
26MP0001730_embryonic_growth_arrest1.74589247
27MP0000490_abnormal_crypts_of1.65519351
28MP0000350_abnormal_cell_proliferation1.59787767
29MP0009278_abnormal_bone_marrow1.56421314
30MP0003172_abnormal_lysosome_physiology1.56092564
31MP0002796_impaired_skin_barrier1.51081944
32MP0001873_stomach_inflammation1.50768027
33MP0005501_abnormal_skin_physiology1.49762053
34MP0009840_abnormal_foam_cell1.48059327
35MP0002723_abnormal_immune_serum1.45201740
36MP0006292_abnormal_olfactory_placode1.41600817
37MP0001819_abnormal_immune_cell1.41481894
38MP0003724_increased_susceptibility_to1.41140964
39MP0003718_maternal_effect1.41124549
40MP0002420_abnormal_adaptive_immunity1.39324650
41MP0001845_abnormal_inflammatory_respons1.37453053
42MP0005058_abnormal_lysosome_morphology1.36081428
43MP0003786_premature_aging1.34484116
44MP0002396_abnormal_hematopoietic_system1.33100870
45MP0010030_abnormal_orbit_morphology1.33073982
46MP0000313_abnormal_cell_death1.32208898
47MP0008469_abnormal_protein_level1.31700995
48MP0000537_abnormal_urethra_morphology1.30806928
49MP0003123_paternal_imprinting1.29292040
50MP0001533_abnormal_skeleton_physiology1.28124210
51MP0000343_altered_response_to1.27834697
52MP0001697_abnormal_embryo_size1.27085088
53MP0005380_embryogenesis_phenotype1.27017485
54MP0001672_abnormal_embryogenesis/_devel1.27017485
55MP0005387_immune_system_phenotype1.26333668
56MP0001790_abnormal_immune_system1.26333668
57MP0009785_altered_susceptibility_to1.23573194
58MP0006036_abnormal_mitochondrial_physio1.23465407
59MP0006035_abnormal_mitochondrial_morpho1.23308172
60MP0003453_abnormal_keratinocyte_physiol1.22416634
61MP0002080_prenatal_lethality1.21488549
62MP0000858_altered_metastatic_potential1.20732807
63MP0004947_skin_inflammation1.19977877
64MP0002653_abnormal_ependyma_morphology1.18845292
65MP0002019_abnormal_tumor_incidence1.18746976
66MP0002139_abnormal_hepatobiliary_system1.17506754
67MP0003984_embryonic_growth_retardation1.16508889
68MP0008875_abnormal_xenobiotic_pharmacok1.16321167
69MP0005266_abnormal_metabolism1.15876305
70MP0000358_abnormal_cell_content/1.15405089
71MP0003705_abnormal_hypodermis_morpholog1.13872945
72MP0002085_abnormal_embryonic_tissue1.13670860
73MP0002088_abnormal_embryonic_growth/wei1.13466542
74MP0010234_abnormal_vibrissa_follicle1.13216960
75MP0003075_altered_response_to1.12467527
76MP0002132_abnormal_respiratory_system1.11750285
77MP0003436_decreased_susceptibility_to1.09545291
78MP0002086_abnormal_extraembryonic_tissu1.09195921
79MP0005365_abnormal_bile_salt1.08966616
80MP0005410_abnormal_fertilization1.08798041
81MP0008004_abnormal_stomach_pH1.02471573
82MP0000477_abnormal_intestine_morphology1.01637347
83MP0001293_anophthalmia1.00675127
84MP0004185_abnormal_adipocyte_glucose0.99519158
85MP0001835_abnormal_antigen_presentation0.99329616
86MP0002210_abnormal_sex_determination0.98635524
87MP0000689_abnormal_spleen_morphology0.98567594
88MP0003011_delayed_dark_adaptation0.98180698
89MP0003119_abnormal_digestive_system0.97504053
90MP0003866_abnormal_defecation0.97121107
91MP0004197_abnormal_fetal_growth/weight/0.97033246
92MP0000703_abnormal_thymus_morphology0.96523100
93MP0005083_abnormal_biliary_tract0.96366669
94MP0005397_hematopoietic_system_phenotyp0.95553824
95MP0001545_abnormal_hematopoietic_system0.95553824
96MP0006082_CNS_inflammation0.94502589
97MP0010155_abnormal_intestine_physiology0.94231782
98MP0005584_abnormal_enzyme/coenzyme_acti0.93151112
99MP0001145_abnormal_male_reproductive0.92935812
100MP0005023_abnormal_wound_healing0.91786796
101MP0002254_reproductive_system_inflammat0.91612849
102MP0001216_abnormal_epidermal_layer0.89899837
103MP0002722_abnormal_immune_system0.89880235
104MP0009764_decreased_sensitivity_to0.89684664
105MP0001727_abnormal_embryo_implantation0.89583876
106MP0000609_abnormal_liver_physiology0.89322859
107MP0005025_abnormal_response_to0.89073768
108MP0004381_abnormal_hair_follicle0.88846239
109MP0002084_abnormal_developmental_patter0.87370533
110MP0003890_abnormal_embryonic-extraembry0.86706639
111MP0005671_abnormal_response_to0.86565957
112MP0001764_abnormal_homeostasis0.86266147
113MP0002405_respiratory_system_inflammati0.85796861
114MP0003448_altered_tumor_morphology0.84558435
115MP0002429_abnormal_blood_cell0.84349448
116MP0000678_abnormal_parathyroid_gland0.84082749
117MP0001661_extended_life_span0.83606717
118MP0001929_abnormal_gametogenesis0.83212238
119MP0001881_abnormal_mammary_gland0.82735919
120MP0000598_abnormal_liver_morphology0.82603884
121MP0003566_abnormal_cell_adhesion0.82466559
122MP0003567_abnormal_fetal_cardiomyocyte0.80614879
123MP0009931_abnormal_skin_appearance0.80171787
124MP0002148_abnormal_hypersensitivity_rea0.80075258
125MP0002398_abnormal_bone_marrow0.79505327
126MP0000015_abnormal_ear_pigmentation0.79241183
127MP0009643_abnormal_urine_homeostasis0.79136465
128MP0004858_abnormal_nervous_system0.78890211
129MP0001853_heart_inflammation0.76146836
130MP0005319_abnormal_enzyme/_coenzyme0.76065027
131MP0003763_abnormal_thymus_physiology0.74859079
132MP0001849_ear_inflammation0.74316064
133MP0003950_abnormal_plasma_membrane0.74216450
134MP0005360_urolithiasis0.73245223
135MP0000716_abnormal_immune_system0.72252900
136MP0000462_abnormal_digestive_system0.70041869
137MP0002452_abnormal_antigen_presenting0.69781571
138MP0010307_abnormal_tumor_latency0.69543013
139MP0005332_abnormal_amino_acid0.69216428
140MP0005408_hypopigmentation0.68035259
141MP0000685_abnormal_immune_system0.68016151
142MP0000653_abnormal_sex_gland0.67837270
143MP0000516_abnormal_urinary_system0.66809622
144MP0005367_renal/urinary_system_phenotyp0.66809622
145MP0005376_homeostasis/metabolism_phenot0.66659993
146MP0001800_abnormal_humoral_immune0.65811823
147MP0005000_abnormal_immune_tolerance0.65781325

Predicted human phenotypes

RankGene SetZ-score
1Multiple enchondromatosis (HP:0005701)4.28756767
2Trismus (HP:0000211)4.10907365
3Abnormality of cells of the erythroid lineage (HP:0012130)3.85212411
4Abnormality of glycolipid metabolism (HP:0010969)3.65021982
5Abnormality of liposaccharide metabolism (HP:0010968)3.65021982
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.65021982
7Abnormal number of erythroid precursors (HP:0012131)3.64232546
8Recurrent abscess formation (HP:0002722)3.34323247
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.33521069
10Abnormality of macrophages (HP:0004311)3.20336309
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17018023
12Degeneration of anterior horn cells (HP:0002398)3.16461000
13Abnormality of the anterior horn cell (HP:0006802)3.16461000
14Breast hypoplasia (HP:0003187)3.12557525
15Poikiloderma (HP:0001029)3.07870553
16Reticulocytopenia (HP:0001896)3.07550281
17Type I transferrin isoform profile (HP:0003642)3.06841901
18Aplastic anemia (HP:0001915)3.06811148
19Purpura (HP:0000979)3.01148224
20Testicular atrophy (HP:0000029)2.93672274
21Carpal bone hypoplasia (HP:0001498)2.92140449
22Obstructive lung disease (HP:0006536)2.87940295
23Chronic obstructive pulmonary disease (HP:0006510)2.87940295
24Rough bone trabeculation (HP:0100670)2.87007500
25Vacuolated lymphocytes (HP:0001922)2.84569474
26Cerebral hypomyelination (HP:0006808)2.82416080
27Birth length less than 3rd percentile (HP:0003561)2.75283892
28Recurrent bacterial skin infections (HP:0005406)2.72960633
29Reduced antithrombin III activity (HP:0001976)2.72067968
30Hepatosplenomegaly (HP:0001433)2.70604101
31Increased cerebral lipofuscin (HP:0011813)2.70589817
32Microretrognathia (HP:0000308)2.66891031
33Tongue fasciculations (HP:0001308)2.64950610
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.64060937
35Increased intramyocellular lipid droplets (HP:0012240)2.62845323
36Ragged-red muscle fibers (HP:0003200)2.61894678
37Aplasia/hypoplasia of the humerus (HP:0006507)2.60098474
38Abnormality of the 1st metacarpal (HP:0010009)2.59765326
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59071701
40Eczematoid dermatitis (HP:0000976)2.56713317
41Vertebral compression fractures (HP:0002953)2.55668853
42Increased muscle lipid content (HP:0009058)2.55555585
43Oral leukoplakia (HP:0002745)2.51834581
44Hypertensive crisis (HP:0100735)2.51497554
45Macrocytic anemia (HP:0001972)2.51438184
46Hypokinesia (HP:0002375)2.47709493
47Progressive neurologic deterioration (HP:0002344)2.46309306
483-Methylglutaconic aciduria (HP:0003535)2.40304597
49Dysostosis multiplex (HP:0000943)2.36978674
50Increased serum ferritin (HP:0003281)2.34442417
51Muscle fibrillation (HP:0010546)2.33816807
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33523702
53Abnormal protein N-linked glycosylation (HP:0012347)2.33523702
54Abnormal protein glycosylation (HP:0012346)2.33523702
55Abnormal glycosylation (HP:0012345)2.33523702
56Selective tooth agenesis (HP:0001592)2.31152791
57Pallor (HP:0000980)2.29787365
58Respiratory difficulties (HP:0002880)2.29387752
59Systemic lupus erythematosus (HP:0002725)2.29150737
60Ileus (HP:0002595)2.29102620
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28548611
62Abnormal trabecular bone morphology (HP:0100671)2.27820997
63Hepatic necrosis (HP:0002605)2.27711171
64Abnormality of glycolysis (HP:0004366)2.27504818
65Increased serum pyruvate (HP:0003542)2.27504818
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27033906
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27033906
68Increased CSF lactate (HP:0002490)2.27026503
69Hepatocellular necrosis (HP:0001404)2.25935828
70Progressive muscle weakness (HP:0003323)2.25577739
71Mitochondrial inheritance (HP:0001427)2.25322454
72Increased serum lactate (HP:0002151)2.25195327
73Short humerus (HP:0005792)2.23798829
74Cholecystitis (HP:0001082)2.23359386
75Abnormal gallbladder physiology (HP:0012438)2.23359386
76Poor head control (HP:0002421)2.23213181
77Increased hepatocellular lipid droplets (HP:0006565)2.21731459
78Loss of speech (HP:0002371)2.21682717
79Abnormal cartilage morphology (HP:0002763)2.20497448
80Pustule (HP:0200039)2.20343524
81Lipid accumulation in hepatocytes (HP:0006561)2.18972376
82Rectal fistula (HP:0100590)2.17144715
83Rectovaginal fistula (HP:0000143)2.17144715
84Acute encephalopathy (HP:0006846)2.15435179
85Acute necrotizing encephalopathy (HP:0006965)2.15368282
86Elevated erythrocyte sedimentation rate (HP:0003565)2.13973865
87Exertional dyspnea (HP:0002875)2.13710471
88Microvesicular hepatic steatosis (HP:0001414)2.11357513
89Hypoplasia of the radius (HP:0002984)2.10796424
90Pancytopenia (HP:0001876)2.10080678
91Vaginal fistula (HP:0004320)2.07785924
92Abnormality of pyrimidine metabolism (HP:0004353)2.05660436
93Absent thumb (HP:0009777)2.05043730
94Short phalanx of the thumb (HP:0009660)2.03882194
95Distal lower limb muscle weakness (HP:0009053)2.03709286
96Abnormality of the preputium (HP:0100587)2.03186070
97Premature ovarian failure (HP:0008209)2.03003484
98Cheilitis (HP:0100825)2.01035808
99Cleft eyelid (HP:0000625)2.00922710
100Recurrent gram-negative bacterial infections (HP:0005420)1.99938436
101Absent radius (HP:0003974)1.99020567
102Impulsivity (HP:0100710)1.98651341
103Increased IgM level (HP:0003496)1.97628844
104Septate vagina (HP:0001153)1.97085534
105Urticaria (HP:0001025)1.96251158
106Abnormality of placental membranes (HP:0011409)1.96082516
107Amniotic constriction ring (HP:0009775)1.96082516
108Petechiae (HP:0000967)1.96041571
109Premature graying of hair (HP:0002216)1.95593834
110Patellar aplasia (HP:0006443)1.93935240
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.93732038
112Thrombocytosis (HP:0001894)1.93387802
113Asplenia (HP:0001746)1.92779705
114Partial duplication of thumb phalanx (HP:0009944)1.91254058
115Renal Fanconi syndrome (HP:0001994)1.90507538
116Sparse eyelashes (HP:0000653)1.87352115
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87102922
118Absent forearm bone (HP:0003953)1.86375173
119Aplasia involving forearm bones (HP:0009822)1.86375173
120Bone marrow hypocellularity (HP:0005528)1.86343699
121Abnormality of polysaccharide metabolism (HP:0011012)1.86133265
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86133265
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86133265
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84434874
125Dicarboxylic aciduria (HP:0003215)1.84434874
126Rib fusion (HP:0000902)1.84401138
127Opisthotonus (HP:0002179)1.84355837
128Abnormality of iron homeostasis (HP:0011031)1.84331117
129Abnormal mitochondria in muscle tissue (HP:0008316)1.83999699
130Ependymoma (HP:0002888)1.83862012
131Abnormal lung lobation (HP:0002101)1.82992396
132Aplasia/Hypoplasia of the patella (HP:0006498)1.82288177
133Mediastinal lymphadenopathy (HP:0100721)1.82164905
134Cerebral edema (HP:0002181)1.79286409
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.79004362
136Tracheoesophageal fistula (HP:0002575)1.78138945
137Glossoptosis (HP:0000162)1.78102836
138Axonal loss (HP:0003447)1.77523643
139Fused cervical vertebrae (HP:0002949)1.77234198
140Recurrent skin infections (HP:0001581)1.75994177
141Prolonged neonatal jaundice (HP:0006579)1.75866912
142Esophageal neoplasm (HP:0100751)1.75619158
143Neoplasm of head and neck (HP:0012288)1.75619158
144Abnormality of the 2nd finger (HP:0004100)1.75190749
145Rhabdomyosarcoma (HP:0002859)1.74974293
146Meningitis (HP:0001287)1.74661220
147Lactic acidosis (HP:0003128)1.74196001
148Fasciculations (HP:0002380)1.73311744
149Exercise intolerance (HP:0003546)1.72122643
150Prolonged bleeding time (HP:0003010)1.71877068
151Mucopolysacchariduria (HP:0008155)1.71318419
152Urinary glycosaminoglycan excretion (HP:0003541)1.71318419
153Recurrent fungal infections (HP:0002841)1.71129262
154Epistaxis (HP:0000421)1.70690099
155Recurrent viral infections (HP:0004429)1.70175955
156Cellulitis (HP:0100658)1.70169644
157Seborrheic dermatitis (HP:0001051)1.69502860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.02820146
2VRK23.44783627
3WEE13.33242946
4TESK23.29365177
5NME23.09881646
6EIF2AK13.06096754
7PIM22.23469703
8SMG12.18315515
9TTK2.17851631
10TESK12.17690364
11ERN12.17543577
12STK162.15267959
13EPHA22.09142617
14CDC71.99776010
15TRIB31.84453909
16CDK121.83218655
17EIF2AK31.82119334
18CDK71.79854278
19NEK21.72272525
20PBK1.68697506
21BCKDK1.64747496
22DYRK31.62428312
23MAP3K121.61340508
24SIK11.58197079
25PLK11.55612318
26PLK41.53820921
27MAP3K111.53181136
28STK101.51835892
29MAP4K11.46222478
30LIMK11.46112816
31VRK11.43327029
32BLK1.41409151
33GRK61.40488058
34SRPK11.36312257
35PRPF4B1.35312306
36CHEK21.35302666
37KDR1.34541259
38RPS6KB21.29778602
39FLT31.27858106
40PAK41.27783921
41NEK11.25851919
42MAP3K81.25375038
43MAPKAPK31.20268211
44AURKB1.18513076
45MST1R1.18416272
46BRAF1.17652494
47DAPK11.14971162
48AURKA1.12786365
49ILK1.10320625
50RIPK41.09957335
51MAP2K21.08348419
52SIK31.06784756
53RPS6KA41.04063823
54PASK1.03202707
55PIM11.01339276
56ADRBK21.00981454
57MATK1.00356268
58PAK10.99816355
59MAP2K30.96955054
60MST40.95856112
61ARAF0.95081322
62ABL20.94070633
63STK40.93731859
64DYRK20.93534622
65TAOK10.92601234
66BRSK20.92566470
67GRK10.89827248
68JAK30.88823512
69ATR0.87399750
70CSF1R0.87186971
71IRAK30.85417222
72LRRK20.81455215
73TLK10.81263993
74IKBKE0.80458468
75CDK40.80217739
76PRKG20.79708280
77ACVR1B0.78787108
78PRKCI0.77717314
79MET0.76241935
80CDK80.75644533
81IKBKB0.74241996
82ZAP700.73216343
83PDK20.70194377
84MYLK0.69796351
85CSNK2A10.68484507
86MAP3K100.68091576
87SCYL20.67549562
88NME10.65903065
89CDK190.65495975
90MAP3K30.65094369
91TNK20.64555487
92DAPK30.62043168
93MAP3K10.61964801
94PTK60.61807744
95CHEK10.61406750
96BMX0.60935202
97GRK50.56311226
98CSNK2A20.55866980
99MOS0.55041448
100IRAK20.55034378
101IRAK40.53661178
102BTK0.53359072
103TGFBR10.52177422
104PRKD20.51433125
105MAPKAPK20.51016260
106MUSK0.50595624
107EPHB10.49051950
108TBK10.47546464
109PDPK10.45844915
110TSSK60.45245488
111MARK30.44898085
112CDK20.44123875
113EIF2AK20.42675205
114MAP3K140.42597509
115LYN0.42557632
116CLK10.42288556
117MAPK110.41596900
118ATM0.40291517
119TEC0.40186092
120TAOK20.39592454
121KIT0.39217987
122TYK20.38266236
123HCK0.37194892
124AKT20.36249079
125RPS6KA50.35683973
126ZAK0.35213112
127PTK20.35136515
128PRKCD0.35011134
129ICK0.34095124
130MKNK10.32286233
131STK390.30981918
132CSK0.30927515
133PKN20.30114385
134BRSK10.29930650
135PLK30.27272106

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.94501079
2DNA replication_Homo sapiens_hsa030303.81959921
3Proteasome_Homo sapiens_hsa030503.73766528
4Mismatch repair_Homo sapiens_hsa034303.40468108
5RNA polymerase_Homo sapiens_hsa030202.99885141
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77174965
7Homologous recombination_Homo sapiens_hsa034402.51301537
8Base excision repair_Homo sapiens_hsa034102.47311715
9Pyrimidine metabolism_Homo sapiens_hsa002402.37505597
10Nucleotide excision repair_Homo sapiens_hsa034202.20870209
11Spliceosome_Homo sapiens_hsa030402.18180087
12RNA transport_Homo sapiens_hsa030132.05664969
13Folate biosynthesis_Homo sapiens_hsa007902.01502392
14One carbon pool by folate_Homo sapiens_hsa006701.88837101
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81726716
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79448556
17Sulfur relay system_Homo sapiens_hsa041221.72141595
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70269874
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.68023494
20Lysosome_Homo sapiens_hsa041421.65733393
21Oxidative phosphorylation_Homo sapiens_hsa001901.64709105
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56977326
23Parkinsons disease_Homo sapiens_hsa050121.48799112
24Cell cycle_Homo sapiens_hsa041101.44963378
25Fructose and mannose metabolism_Homo sapiens_hsa000511.43500962
26Protein export_Homo sapiens_hsa030601.42620613
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.31482382
28Fanconi anemia pathway_Homo sapiens_hsa034601.30545264
29Basal transcription factors_Homo sapiens_hsa030221.29755936
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26682875
31Huntingtons disease_Homo sapiens_hsa050161.25348918
32Glutathione metabolism_Homo sapiens_hsa004801.20465275
33Sulfur metabolism_Homo sapiens_hsa009201.19245624
34Non-homologous end-joining_Homo sapiens_hsa034501.18847312
35Galactose metabolism_Homo sapiens_hsa000521.16006923
36Pentose phosphate pathway_Homo sapiens_hsa000301.13569250
37Selenocompound metabolism_Homo sapiens_hsa004501.12953709
38Vitamin B6 metabolism_Homo sapiens_hsa007501.10430358
39Purine metabolism_Homo sapiens_hsa002301.04737960
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03990649
41RNA degradation_Homo sapiens_hsa030181.03240482
42Steroid biosynthesis_Homo sapiens_hsa001001.02293431
43Vibrio cholerae infection_Homo sapiens_hsa051101.01836890
44p53 signaling pathway_Homo sapiens_hsa041150.99919539
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.99765182
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99537272
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99506731
48Allograft rejection_Homo sapiens_hsa053300.97081717
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94194419
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93236334
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92251197
52Biosynthesis of amino acids_Homo sapiens_hsa012300.91488810
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87810369
54Staphylococcus aureus infection_Homo sapiens_hsa051500.87789043
55Carbon metabolism_Homo sapiens_hsa012000.85020625
56Alzheimers disease_Homo sapiens_hsa050100.84690382
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83816077
58Autoimmune thyroid disease_Homo sapiens_hsa053200.82711992
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80495987
60Arachidonic acid metabolism_Homo sapiens_hsa005900.75412587
61Acute myeloid leukemia_Homo sapiens_hsa052210.74460091
62Legionellosis_Homo sapiens_hsa051340.74109894
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73716107
64Epstein-Barr virus infection_Homo sapiens_hsa051690.73106236
65Graft-versus-host disease_Homo sapiens_hsa053320.72687239
66Rheumatoid arthritis_Homo sapiens_hsa053230.72529578
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72465895
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71055341
69Osteoclast differentiation_Homo sapiens_hsa043800.70895200
70Metabolic pathways_Homo sapiens_hsa011000.70024412
71Asthma_Homo sapiens_hsa053100.69509245
72Tuberculosis_Homo sapiens_hsa051520.67905519
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.67678411
74Fatty acid elongation_Homo sapiens_hsa000620.67243310
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66919912
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65214659
77Arginine and proline metabolism_Homo sapiens_hsa003300.64409400
78Sphingolipid metabolism_Homo sapiens_hsa006000.63096031
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.62397542
80mRNA surveillance pathway_Homo sapiens_hsa030150.62392126
81Linoleic acid metabolism_Homo sapiens_hsa005910.62197469
82Thyroid cancer_Homo sapiens_hsa052160.61777774
83Caffeine metabolism_Homo sapiens_hsa002320.61325663
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60797017
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60188569
86Antigen processing and presentation_Homo sapiens_hsa046120.59093196
87Herpes simplex infection_Homo sapiens_hsa051680.58333291
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55706084
89Hepatitis C_Homo sapiens_hsa051600.55450480
90Collecting duct acid secretion_Homo sapiens_hsa049660.55013344
91Hematopoietic cell lineage_Homo sapiens_hsa046400.54050784
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52225151
93Viral myocarditis_Homo sapiens_hsa054160.51883546
94Phenylalanine metabolism_Homo sapiens_hsa003600.51770322
95Phagosome_Homo sapiens_hsa041450.51646516
96Chemical carcinogenesis_Homo sapiens_hsa052040.51122859
97Vitamin digestion and absorption_Homo sapiens_hsa049770.50804209
98Influenza A_Homo sapiens_hsa051640.50634837
99Systemic lupus erythematosus_Homo sapiens_hsa053220.49960279
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49178347
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44635096
102Histidine metabolism_Homo sapiens_hsa003400.44578839
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44435362
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44325519
105Pertussis_Homo sapiens_hsa051330.43815167
106Peroxisome_Homo sapiens_hsa041460.43723811
107Other glycan degradation_Homo sapiens_hsa005110.42931969
108Type I diabetes mellitus_Homo sapiens_hsa049400.42913715
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42477811
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.42013773
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41047282
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40895398
113N-Glycan biosynthesis_Homo sapiens_hsa005100.37486474
114Shigellosis_Homo sapiens_hsa051310.35404078
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33609842
116Fat digestion and absorption_Homo sapiens_hsa049750.32145399
117Leishmaniasis_Homo sapiens_hsa051400.31793053
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31468255
119Apoptosis_Homo sapiens_hsa042100.30513817
120Bladder cancer_Homo sapiens_hsa052190.28547100
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.27965559
122Viral carcinogenesis_Homo sapiens_hsa052030.27780661
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.26910394
124Pyruvate metabolism_Homo sapiens_hsa006200.23610075
125Tyrosine metabolism_Homo sapiens_hsa003500.23150436
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22919991
127Salmonella infection_Homo sapiens_hsa051320.22593229
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22508449
129Primary immunodeficiency_Homo sapiens_hsa053400.22178373
130Regulation of autophagy_Homo sapiens_hsa041400.22022112
131Measles_Homo sapiens_hsa051620.21188624
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21023763
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20063392
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.19140470

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