ZDHHC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.43882930
2DNA unwinding involved in DNA replication (GO:0006268)4.64795457
3DNA strand elongation involved in DNA replication (GO:0006271)4.21624471
4DNA replication initiation (GO:0006270)4.19093446
5telomere maintenance via semi-conservative replication (GO:0032201)4.08467815
6replication fork processing (GO:0031297)4.03272305
7cilium or flagellum-dependent cell motility (GO:0001539)3.99982546
8mitotic chromosome condensation (GO:0007076)3.97965054
9DNA strand elongation (GO:0022616)3.97814162
10ribosomal small subunit assembly (GO:0000028)3.88941425
11RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.85770844
12protein localization to cilium (GO:0061512)3.78454555
13mitotic recombination (GO:0006312)3.73871285
14telomere maintenance via recombination (GO:0000722)3.72912804
15mitotic nuclear envelope disassembly (GO:0007077)3.71019563
16response to pheromone (GO:0019236)3.63791034
17axonemal dynein complex assembly (GO:0070286)3.63560869
18neural tube formation (GO:0001841)3.62293376
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.61348185
20epithelial cilium movement (GO:0003351)3.57970754
21centriole replication (GO:0007099)3.54606660
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52801742
23CENP-A containing nucleosome assembly (GO:0034080)3.51870902
24folic acid-containing compound biosynthetic process (GO:0009396)3.47790222
25membrane disassembly (GO:0030397)3.46933064
26nuclear envelope disassembly (GO:0051081)3.46933064
27protein localization to kinetochore (GO:0034501)3.43191552
28nuclear pore complex assembly (GO:0051292)3.40802517
29recombinational repair (GO:0000725)3.39692185
30double-strand break repair via homologous recombination (GO:0000724)3.38898318
31chromatin remodeling at centromere (GO:0031055)3.36049644
32maturation of SSU-rRNA (GO:0030490)3.33812556
33axoneme assembly (GO:0035082)3.33759400
34cilium movement (GO:0003341)3.32755189
35telomere maintenance via telomere lengthening (GO:0010833)3.32097673
36nuclear pore organization (GO:0006999)3.31861025
37inositol phosphate catabolic process (GO:0071545)3.31046530
38formation of translation preinitiation complex (GO:0001731)3.30937906
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30798566
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29029315
41DNA replication-independent nucleosome assembly (GO:0006336)3.24857425
42DNA replication-independent nucleosome organization (GO:0034724)3.24857425
43IMP biosynthetic process (GO:0006188)3.24737647
44platelet dense granule organization (GO:0060155)3.20131153
45protein complex biogenesis (GO:0070271)3.19244683
46histone H2A acetylation (GO:0043968)3.17790678
47DNA catabolic process, exonucleolytic (GO:0000738)3.16163603
48protein localization to chromosome, centromeric region (GO:0071459)3.14945629
49regulation of histone H3-K9 methylation (GO:0051570)3.14717524
50DNA duplex unwinding (GO:0032508)3.12629915
51maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10918488
52DNA geometric change (GO:0032392)3.08205364
53DNA deamination (GO:0045006)3.07980295
54intraciliary transport (GO:0042073)3.05866426
55keratinocyte development (GO:0003334)3.05123892
56phosphorylated carbohydrate dephosphorylation (GO:0046838)3.03730872
57inositol phosphate dephosphorylation (GO:0046855)3.03730872
58attachment of spindle microtubules to kinetochore (GO:0008608)3.01721599
59IMP metabolic process (GO:0046040)2.98946881
60viral transcription (GO:0019083)2.98053570
61rRNA catabolic process (GO:0016075)2.96539404
62synapsis (GO:0007129)2.95242883
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.94780002
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94780002
65DNA replication checkpoint (GO:0000076)2.94315942
66mitochondrial respiratory chain complex assembly (GO:0033108)2.94212065
67polyol catabolic process (GO:0046174)2.94005657
68translational termination (GO:0006415)2.93876405
69positive regulation of glycoprotein biosynthetic process (GO:0010560)2.93407763
70negative regulation of telomere maintenance (GO:0032205)2.92191698
71translesion synthesis (GO:0019985)2.90634124
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90495300
73regulation of mitotic spindle checkpoint (GO:1903504)2.90495300
74cilium organization (GO:0044782)2.89933906
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.89875792
76kinetochore organization (GO:0051383)2.89323473
77negative regulation of RNA splicing (GO:0033119)2.88539207
78DNA replication-dependent nucleosome assembly (GO:0006335)2.87999680
79DNA replication-dependent nucleosome organization (GO:0034723)2.87999680
80respiratory chain complex IV assembly (GO:0008535)2.87535942
81centriole assembly (GO:0098534)2.85980443
82cytochrome complex assembly (GO:0017004)2.85664053
83fucose catabolic process (GO:0019317)2.83047284
84L-fucose metabolic process (GO:0042354)2.83047284
85L-fucose catabolic process (GO:0042355)2.83047284
86sister chromatid segregation (GO:0000819)2.82628986
87preassembly of GPI anchor in ER membrane (GO:0016254)2.82280454
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81335925
89protein K11-linked deubiquitination (GO:0035871)2.80945789
90negative regulation of histone methylation (GO:0031061)2.80549199
91cilium assembly (GO:0042384)2.80179570
92postreplication repair (GO:0006301)2.79167765
93translational elongation (GO:0006414)2.78423107
94response to X-ray (GO:0010165)2.77956498
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75881708
96DNA integration (GO:0015074)2.75821942
97mitotic metaphase plate congression (GO:0007080)2.75698797
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75484218
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.75484218
100NADH dehydrogenase complex assembly (GO:0010257)2.75484218
101translational initiation (GO:0006413)2.75303773
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75278588
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74942148
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74742376
105histone exchange (GO:0043486)2.74510039
106telomere maintenance (GO:0000723)2.74447679
107nucleobase biosynthetic process (GO:0046112)2.74185581
108negative regulation of neurological system process (GO:0031645)2.73292829
109actin nucleation (GO:0045010)2.72757936
110nuclear envelope organization (GO:0006998)2.72455407
111telomere organization (GO:0032200)2.72236139
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71392465
113regulation of protein heterodimerization activity (GO:0043497)2.71311903
114DNA topological change (GO:0006265)2.70900647
115mitotic sister chromatid segregation (GO:0000070)2.70414855
116non-recombinational repair (GO:0000726)2.69451392
117double-strand break repair via nonhomologous end joining (GO:0006303)2.69451392
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.69380477
119protein deneddylation (GO:0000338)2.69007230
120establishment of chromosome localization (GO:0051303)2.68950425
121prenylation (GO:0097354)2.68842245
122protein prenylation (GO:0018342)2.68842245
123water-soluble vitamin biosynthetic process (GO:0042364)2.66929130
124ubiquinone biosynthetic process (GO:0006744)2.65606518
125meiotic chromosome segregation (GO:0045132)2.65418163
126regulation of DNA endoreduplication (GO:0032875)2.65102396
127DNA conformation change (GO:0071103)2.64909343
128regulation of cilium movement (GO:0003352)2.63680276
129cullin deneddylation (GO:0010388)2.63479961
130ubiquinone metabolic process (GO:0006743)2.63167425
131chromatin assembly or disassembly (GO:0006333)2.63117969
132cilium morphogenesis (GO:0060271)2.63030791
133negative regulation of DNA repair (GO:0045738)2.62185571
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61892476
135cotranslational protein targeting to membrane (GO:0006613)2.61867315
136DNA strand renaturation (GO:0000733)2.61854239
137somatic diversification of immunoglobulins (GO:0016445)2.61594493
138positive regulation of glycoprotein metabolic process (GO:1903020)2.61500429
139ribosome assembly (GO:0042255)2.61450049
140histone H2A ubiquitination (GO:0033522)2.61384826
141regulation of RIG-I signaling pathway (GO:0039535)2.61062091
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60706115
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60706115
144mannosylation (GO:0097502)2.60462243
145metaphase plate congression (GO:0051310)2.59996235
146ribosome biogenesis (GO:0042254)2.59964723
147negative regulation of DNA recombination (GO:0045910)2.59907749
148nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59579445
149mitochondrial DNA replication (GO:0006264)2.59456954
150protein targeting to ER (GO:0045047)2.59194852
151positive regulation of histone H3-K4 methylation (GO:0051571)2.57897199
152pseudouridine synthesis (GO:0001522)2.57747084
153pore complex assembly (GO:0046931)2.57492007
154photoreceptor cell maintenance (GO:0045494)2.57117261
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57026612
156regulation of centrosome cycle (GO:0046605)2.56703420
157double-strand break repair (GO:0006302)2.56554158
158positive regulation of B cell differentiation (GO:0045579)2.55567172
159somatic recombination of immunoglobulin gene segments (GO:0016447)2.54824164
160mitotic sister chromatid cohesion (GO:0007064)2.54691179
161GPI anchor metabolic process (GO:0006505)2.53739901
162dosage compensation (GO:0007549)2.52840071
163reciprocal meiotic recombination (GO:0007131)2.52815156
164reciprocal DNA recombination (GO:0035825)2.52815156
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51749314
166prostate gland growth (GO:0060736)2.50496077
167cellular ketone body metabolic process (GO:0046950)2.50361078
168regulation of telomere maintenance (GO:0032204)2.50297024
169mismatch repair (GO:0006298)2.48709628
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48618650
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48618650
172isotype switching (GO:0045190)2.48618650
173signal peptide processing (GO:0006465)2.48534014
174establishment of integrated proviral latency (GO:0075713)2.48497318
175mitochondrial calcium ion transport (GO:0006851)2.48245831
176hepatocyte apoptotic process (GO:0097284)2.47854496
177regulation of meiosis I (GO:0060631)2.47339755
178inner mitochondrial membrane organization (GO:0007007)2.47246792
179regulation of centriole replication (GO:0046599)2.46618647
180T cell homeostasis (GO:0043029)2.46500335
181C-terminal protein amino acid modification (GO:0018410)2.46490349
182maturation of 5.8S rRNA (GO:0000460)2.46369714
183establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45851434
184ribonucleoprotein complex biogenesis (GO:0022613)2.44547519
185regulation of spindle organization (GO:0090224)2.44295689
186deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44226352
187snRNA processing (GO:0016180)2.41981968
188maintenance of gastrointestinal epithelium (GO:0030277)2.41975253
189protein localization to endoplasmic reticulum (GO:0070972)2.40596066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.57027724
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89287809
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69188717
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59935220
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.48640255
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.21048616
7ZNF274_21170338_ChIP-Seq_K562_Hela3.07924062
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.95077992
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87544599
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81272163
11VDR_22108803_ChIP-Seq_LS180_Human2.71963577
12IGF1R_20145208_ChIP-Seq_DFB_Human2.70973427
13FUS_26573619_Chip-Seq_HEK293_Human2.62224387
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61318155
15AR_21909140_ChIP-Seq_LNCAP_Human2.54946918
16MYC_22102868_ChIP-Seq_BL_Human2.52863950
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49523977
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.46855704
19EWS_26573619_Chip-Seq_HEK293_Human2.41385090
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40998712
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37606502
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29627846
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28745348
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.27978462
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27406400
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.25807557
27GBX2_23144817_ChIP-Seq_PC3_Human2.20034445
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18875877
29VDR_23849224_ChIP-Seq_CD4+_Human2.18045230
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17952356
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.15868183
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13680690
33TAF15_26573619_Chip-Seq_HEK293_Human2.09184223
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03826536
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01855322
36P300_19829295_ChIP-Seq_ESCs_Human1.99749091
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.97906844
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96992037
39XRN2_22483619_ChIP-Seq_HELA_Human1.96026128
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89905728
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88298288
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88101589
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87067042
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83932719
45ER_23166858_ChIP-Seq_MCF-7_Human1.83909397
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83521397
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83130519
48CIITA_25753668_ChIP-Seq_RAJI_Human1.79377797
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78431754
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77441325
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77231592
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75704011
53ELK1_19687146_ChIP-ChIP_HELA_Human1.75325869
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73089947
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72453431
56VDR_21846776_ChIP-Seq_THP-1_Human1.71806826
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70454454
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69086730
59FOXP3_21729870_ChIP-Seq_TREG_Human1.68310223
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67730059
61TTF2_22483619_ChIP-Seq_HELA_Human1.66207796
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62820847
63DCP1A_22483619_ChIP-Seq_HELA_Human1.62127371
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60644208
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60254170
66GABP_19822575_ChIP-Seq_HepG2_Human1.58160947
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57443971
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57225941
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56956084
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53791442
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52191970
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52057133
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51226651
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51142417
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50373872
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48630913
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48450504
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48221716
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.47491643
80SMAD4_21799915_ChIP-Seq_A2780_Human1.47070689
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.46335862
82SPI1_23547873_ChIP-Seq_NB4_Human1.44303460
83CBP_20019798_ChIP-Seq_JUKART_Human1.37355121
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37355121
85STAT3_23295773_ChIP-Seq_U87_Human1.36242065
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35830251
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.35508584
88KDM5A_27292631_Chip-Seq_BREAST_Human1.34925668
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34694735
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33556142
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32693842
92TCF4_22108803_ChIP-Seq_LS180_Human1.32248142
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31801144
94TFEB_21752829_ChIP-Seq_HELA_Human1.30998069
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.30947239
96MYB_26560356_Chip-Seq_TH2_Human1.30736267
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.30304298
98BCAT_22108803_ChIP-Seq_LS180_Human1.29688228
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28822191
100IRF1_19129219_ChIP-ChIP_H3396_Human1.28807906
101AR_25329375_ChIP-Seq_VCAP_Human1.28806525
102NANOG_19829295_ChIP-Seq_ESCs_Human1.28522947
103SOX2_19829295_ChIP-Seq_ESCs_Human1.28522947
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27095064
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26198136
106TCF4_23295773_ChIP-Seq_U87_Human1.26040685
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25976489
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24738902
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.24232559
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23640524
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23147484
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23118558
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23078589
114P53_22387025_ChIP-Seq_ESCs_Mouse1.22930156
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22807853
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.21838621
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.21476350
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21209544
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20831440
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20503207
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.19946742
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19946742
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.19074594
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18813288
125P300_18555785_Chip-Seq_ESCs_Mouse1.18202981
126TP53_22573176_ChIP-Seq_HFKS_Human1.17728145
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17465918
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17001728
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16728939
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16654804
131THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15854691
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15745401
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.14376103
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13124305
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12634590
136MYB_26560356_Chip-Seq_TH1_Human1.12447539
137* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11945061
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.11610703
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11321549
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11195179
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10870810
142CDX2_22108803_ChIP-Seq_LS180_Human1.10149705
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10040745
144CRX_20693478_ChIP-Seq_RETINA_Mouse1.09319783
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.08673420
146FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08534929
147OCT4_18555785_Chip-Seq_ESCs_Mouse1.07233429
148SCL_19346495_ChIP-Seq_HPC-7_Human1.06660160
149RUNX2_22187159_ChIP-Seq_PCA_Human1.06044427
150RUNX1_22412390_ChIP-Seq_EML_Mouse1.05666335
151* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05646255
152BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03968805
153NCOR_22424771_ChIP-Seq_293T_Human1.03679468
154SRF_21415370_ChIP-Seq_HL-1_Mouse1.03679386
155VDR_24763502_ChIP-Seq_THP-1_Human1.01626182
156STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00359125
157PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00228357
158MAF_26560356_Chip-Seq_TH1_Human0.99896208
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99787295
160PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99676865
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99257794
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99257794
163AR_20517297_ChIP-Seq_VCAP_Human0.99127634
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98715179
165BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97908773
166* UTX_26944678_Chip-Seq_JUKART_Human0.95672887
167* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94867825
168NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94249503
169POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94143145
170TCF7_22412390_ChIP-Seq_EML_Mouse0.93241272
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91005777
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90025260
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89099690
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88804752
175CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88300467
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88005373
177MYC_18940864_ChIP-ChIP_HL60_Human0.86818808
178PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85725205
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84214756
180NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84179647
181SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83736298
182GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83231846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.62719500
2MP0003693_abnormal_embryo_hatching3.65263861
3MP0010094_abnormal_chromosome_stability3.54968574
4MP0004957_abnormal_blastocyst_morpholog3.40457977
5MP0010352_gastrointestinal_tract_polyps3.28748090
6MP0002102_abnormal_ear_morphology3.10779857
7MP0008057_abnormal_DNA_replication3.10434556
8MP0002396_abnormal_hematopoietic_system3.01905162
9MP0006054_spinal_hemorrhage2.81312011
10MP0003077_abnormal_cell_cycle2.75336349
11MP0003111_abnormal_nucleus_morphology2.63555515
12MP0005645_abnormal_hypothalamus_physiol2.47734059
13MP0000490_abnormal_crypts_of2.45768205
14MP0001835_abnormal_antigen_presentation2.44114815
15MP0009697_abnormal_copulation2.36031612
16MP0003786_premature_aging2.32680604
17MP0008058_abnormal_DNA_repair2.28878605
18MP0003763_abnormal_thymus_physiology2.21007066
19MP0003195_calcinosis2.18512774
20MP0004808_abnormal_hematopoietic_stem2.15348135
21MP0008007_abnormal_cellular_replicative2.08786119
22MP0010307_abnormal_tumor_latency2.05024648
23MP0000372_irregular_coat_pigmentation1.94767840
24MP0005253_abnormal_eye_physiology1.90011830
25MP0006072_abnormal_retinal_apoptosis1.84904289
26MP0002398_abnormal_bone_marrow1.83330772
27MP0004264_abnormal_extraembryonic_tissu1.78686992
28MP0003718_maternal_effect1.78401994
29MP0003283_abnormal_digestive_organ1.77992617
30MP0000383_abnormal_hair_follicle1.75734935
31MP0000516_abnormal_urinary_system1.75287060
32MP0005367_renal/urinary_system_phenotyp1.75287060
33MP0000685_abnormal_immune_system1.73674125
34MP0002160_abnormal_reproductive_system1.72920041
35MP0002166_altered_tumor_susceptibility1.70494804
36MP0009333_abnormal_splenocyte_physiolog1.64681256
37* MP0000427_abnormal_hair_cycle1.62494939
38MP0000350_abnormal_cell_proliferation1.60307025
39MP0001984_abnormal_olfaction1.58708172
40MP0010155_abnormal_intestine_physiology1.57187531
41MP0002138_abnormal_hepatobiliary_system1.57026195
42MP0000647_abnormal_sebaceous_gland1.56587977
43MP0005551_abnormal_eye_electrophysiolog1.56526595
44MP0001800_abnormal_humoral_immune1.55338705
45MP0001873_stomach_inflammation1.55142327
46MP0002938_white_spotting1.53373265
47MP0005671_abnormal_response_to1.52731660
48MP0001730_embryonic_growth_arrest1.52539975
49MP0002234_abnormal_pharynx_morphology1.51423226
50MP0004043_abnormal_pH_regulation1.48480143
51* MP0002722_abnormal_immune_system1.48030213
52MP0008995_early_reproductive_senescence1.47732650
53MP0004947_skin_inflammation1.45417140
54MP0002132_abnormal_respiratory_system1.45067689
55MP0005646_abnormal_pituitary_gland1.44885103
56MP0002452_abnormal_antigen_presenting1.44134828
57MP0008932_abnormal_embryonic_tissue1.44090874
58* MP0000689_abnormal_spleen_morphology1.43372147
59MP0000703_abnormal_thymus_morphology1.42626013
60MP0003123_paternal_imprinting1.41761340
61MP0003121_genomic_imprinting1.40608988
62MP0002420_abnormal_adaptive_immunity1.40152507
63MP0000015_abnormal_ear_pigmentation1.39745296
64MP0003183_abnormal_peptide_metabolism1.39355088
65MP0002006_tumorigenesis1.39292632
66MP0001819_abnormal_immune_cell1.38536685
67MP0005084_abnormal_gallbladder_morpholo1.38171114
68MP0002019_abnormal_tumor_incidence1.38076056
69MP0005389_reproductive_system_phenotype1.37721071
70MP0001545_abnormal_hematopoietic_system1.36478007
71MP0005397_hematopoietic_system_phenotyp1.36478007
72MP0003866_abnormal_defecation1.35320968
73MP0009785_altered_susceptibility_to1.35008444
74* MP0000716_abnormal_immune_system1.34523833
75MP0002837_dystrophic_cardiac_calcinosis1.32181940
76MP0008789_abnormal_olfactory_epithelium1.31748183
77* MP0002429_abnormal_blood_cell1.31549244
78MP0009046_muscle_twitch1.29165160
79MP0002405_respiratory_system_inflammati1.28101460
80MP0004147_increased_porphyrin_level1.26952233
81MP0002751_abnormal_autonomic_nervous1.26418005
82MP0000465_gastrointestinal_hemorrhage1.26101747
83MP0001293_anophthalmia1.25599689
84MP0000631_abnormal_neuroendocrine_gland1.24083429
85MP0005000_abnormal_immune_tolerance1.23541582
86MP0005220_abnormal_exocrine_pancreas1.22450867
87MP0003119_abnormal_digestive_system1.21915297
88MP0008877_abnormal_DNA_methylation1.19572302
89MP0002723_abnormal_immune_serum1.19208652
90MP0004133_heterotaxia1.17247294
91MP0001188_hyperpigmentation1.16910048
92MP0001929_abnormal_gametogenesis1.15856124
93MP0000858_altered_metastatic_potential1.12712507
94MP0000477_abnormal_intestine_morphology1.12251900
95MP0006292_abnormal_olfactory_placode1.11325555
96MP0001529_abnormal_vocalization1.10921594
97MP0001697_abnormal_embryo_size1.10667610
98MP0005025_abnormal_response_to1.10245519
99MP0008872_abnormal_physiological_respon1.08828430
100MP0001853_heart_inflammation1.08668276
101MP0005076_abnormal_cell_differentiation1.08493308
102MP0000613_abnormal_salivary_gland1.08216403
103MP0003315_abnormal_perineum_morphology1.07752866
104MP0003300_gastrointestinal_ulcer1.07200743
105MP0002080_prenatal_lethality1.07091715
106MP0000313_abnormal_cell_death1.06635653
107MP0003880_abnormal_central_pattern1.05466778
108MP0002086_abnormal_extraembryonic_tissu1.04263126
109MP0003937_abnormal_limbs/digits/tail_de1.03829679
110MP0006035_abnormal_mitochondrial_morpho1.03733879
111MP0003436_decreased_susceptibility_to1.03081037
112MP0003656_abnormal_erythrocyte_physiolo1.02480163
113MP0003890_abnormal_embryonic-extraembry1.02356710
114MP0001968_abnormal_touch/_nociception1.00936771
115MP0000653_abnormal_sex_gland1.00504736
116MP0003172_abnormal_lysosome_physiology0.99611405
117MP0003011_delayed_dark_adaptation0.98452366
118MP0003698_abnormal_male_reproductive0.98393595
119MP0005380_embryogenesis_phenotype0.98014514
120MP0001672_abnormal_embryogenesis/_devel0.98014514
121MP0005174_abnormal_tail_pigmentation0.97526315
122MP0001145_abnormal_male_reproductive0.97059205
123MP0004215_abnormal_myocardial_fiber0.96959717
124MP0002009_preneoplasia0.96586117
125MP0003567_abnormal_fetal_cardiomyocyte0.95974388
126MP0003984_embryonic_growth_retardation0.95452573
127MP0010678_abnormal_skin_adnexa0.95164057
128MP0002877_abnormal_melanocyte_morpholog0.93926240
129MP0002088_abnormal_embryonic_growth/wei0.92881140
130MP0006036_abnormal_mitochondrial_physio0.92319940
131MP0005310_abnormal_salivary_gland0.91998880
132MP0005464_abnormal_platelet_physiology0.90668669
133MP0005379_endocrine/exocrine_gland_phen0.90076832
134MP0002419_abnormal_innate_immunity0.89730784
135MP0009780_abnormal_chondrocyte_physiolo0.89221992
136MP0004197_abnormal_fetal_growth/weight/0.88320556
137MP0001764_abnormal_homeostasis0.88222420
138MP0002210_abnormal_sex_determination0.86505654
139MP0005391_vision/eye_phenotype0.86139976
140MP0005075_abnormal_melanosome_morpholog0.85273981
141MP0003943_abnormal_hepatobiliary_system0.85205629
142MP0003252_abnormal_bile_duct0.84674543
143MP0002148_abnormal_hypersensitivity_rea0.84507668
144MP0002095_abnormal_skin_pigmentation0.84192342
145MP0002693_abnormal_pancreas_physiology0.84123087
146MP0003787_abnormal_imprinting0.83483367
147MP0001119_abnormal_female_reproductive0.83052361
148MP0005387_immune_system_phenotype0.82474067
149MP0001790_abnormal_immune_system0.82474067
150MP0002090_abnormal_vision0.82358687
151MP0002736_abnormal_nociception_after0.81921898
152MP0002909_abnormal_adrenal_gland0.81482874
153MP0003566_abnormal_cell_adhesion0.81020205
154MP0006276_abnormal_autonomic_nervous0.80431572
155MP0001919_abnormal_reproductive_system0.78520257
156MP0001845_abnormal_inflammatory_respons0.77940310
157MP0002084_abnormal_developmental_patter0.77881038
158MP0002085_abnormal_embryonic_tissue0.77676177
159MP0003453_abnormal_keratinocyte_physiol0.77403630
160MP0005187_abnormal_penis_morphology0.77054522
161MP0002282_abnormal_trachea_morphology0.76423237
162MP0004142_abnormal_muscle_tone0.76330858
163MP0001986_abnormal_taste_sensitivity0.76292236
164MP0001944_abnormal_pancreas_morphology0.75683641
165MP0000537_abnormal_urethra_morphology0.75189937
166MP0002928_abnormal_bile_duct0.74493247
167MP0003941_abnormal_skin_development0.74060813
168MP0001324_abnormal_eye_pigmentation0.73829976
169MP0002277_abnormal_respiratory_mucosa0.73727810
170MP0001485_abnormal_pinna_reflex0.72096836
171MP0005023_abnormal_wound_healing0.71091906
172MP0002163_abnormal_gland_morphology0.70642389
173MP0005384_cellular_phenotype0.70376186
174MP0001849_ear_inflammation0.70165061
175MP0005621_abnormal_cell_physiology0.69365649
176MP0000569_abnormal_digit_pigmentation0.69070943
177MP0005501_abnormal_skin_physiology0.68960434

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.06554997
2Pancreatic cysts (HP:0001737)3.80929178
3Colon cancer (HP:0003003)3.72366681
4Abnormal number of erythroid precursors (HP:0012131)3.61593822
5Aplastic anemia (HP:0001915)3.61376493
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.60920309
7Absent/shortened dynein arms (HP:0200106)3.60920309
8Abnormality of cells of the erythroid lineage (HP:0012130)3.57214276
9Thrombocytosis (HP:0001894)3.46210018
10Pancreatic fibrosis (HP:0100732)3.43803345
11Birth length less than 3rd percentile (HP:0003561)3.40342246
12Panhypogammaglobulinemia (HP:0003139)3.38822251
13Abnormal respiratory motile cilium morphology (HP:0005938)3.28516408
14Abnormal respiratory epithelium morphology (HP:0012253)3.28516408
15Oral leukoplakia (HP:0002745)3.26378269
16True hermaphroditism (HP:0010459)3.19224597
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.16129206
18Pili torti (HP:0003777)3.15191105
19Agnosia (HP:0010524)3.10848309
20Molar tooth sign on MRI (HP:0002419)3.03749506
21Abnormality of midbrain morphology (HP:0002418)3.03749506
22Reticulocytopenia (HP:0001896)2.95056000
23Recurrent viral infections (HP:0004429)2.93715404
24Chronic otitis media (HP:0000389)2.91887706
25Poikiloderma (HP:0001029)2.86119908
26Hypothermia (HP:0002045)2.82669887
27Medial flaring of the eyebrow (HP:0010747)2.74983079
28Absent frontal sinuses (HP:0002688)2.74774175
29Abnormal ciliary motility (HP:0012262)2.70565251
30Abnormal respiratory motile cilium physiology (HP:0012261)2.70477155
31Abnormality of the renal cortex (HP:0011035)2.70083193
32Nephronophthisis (HP:0000090)2.68489579
33Agammaglobulinemia (HP:0004432)2.66195162
34Abnormality of the anterior horn cell (HP:0006802)2.61065498
35Degeneration of anterior horn cells (HP:0002398)2.61065498
36Myelodysplasia (HP:0002863)2.59976688
37Lymphoma (HP:0002665)2.55644324
38Abnormal rod and cone electroretinograms (HP:0008323)2.55101619
39Chronic hepatic failure (HP:0100626)2.52326294
40Type I transferrin isoform profile (HP:0003642)2.51768944
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51707750
42Pallor (HP:0000980)2.51489989
43Biliary tract neoplasm (HP:0100574)2.49244264
44Amaurosis fugax (HP:0100576)2.48610918
45IgM deficiency (HP:0002850)2.47324472
46Congenital stationary night blindness (HP:0007642)2.47150753
47Petechiae (HP:0000967)2.46118503
48Abnormality of the labia minora (HP:0012880)2.44132569
49Selective tooth agenesis (HP:0001592)2.42464724
50Furrowed tongue (HP:0000221)2.42295327
51Abnormality of the renal medulla (HP:0100957)2.40513605
52Renal cortical cysts (HP:0000803)2.39957199
53Pendular nystagmus (HP:0012043)2.38922069
54Neoplasm of the adrenal cortex (HP:0100641)2.38429591
55Abolished electroretinogram (ERG) (HP:0000550)2.37846416
56Congenital primary aphakia (HP:0007707)2.37698448
57Elevated erythrocyte sedimentation rate (HP:0003565)2.37013960
58Broad face (HP:0000283)2.36600191
59Pulmonary fibrosis (HP:0002206)2.36484846
60Rhinitis (HP:0012384)2.34975409
61Gait imbalance (HP:0002141)2.29009607
62Thyroiditis (HP:0100646)2.28039833
63Papilledema (HP:0001085)2.26029198
64Nephrogenic diabetes insipidus (HP:0009806)2.23796395
65Progressive inability to walk (HP:0002505)2.22890776
66Rough bone trabeculation (HP:0100670)2.22407230
67Chronic bronchitis (HP:0004469)2.22228131
68Intestinal atresia (HP:0011100)2.21678025
69Acute myeloid leukemia (HP:0004808)2.21631157
70Microretrognathia (HP:0000308)2.21356416
71Prominent nose (HP:0000448)2.20298970
72Villous atrophy (HP:0011473)2.19863259
73Abnormality of small intestinal villus morphology (HP:0011472)2.19863259
74Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.19661624
75Fatigue (HP:0012378)2.19217502
76Neoplasm of the small intestine (HP:0100833)2.18109315
77Neoplasm of the pancreas (HP:0002894)2.17693055
78Recurrent bronchitis (HP:0002837)2.16562893
79Abnormality of T cell physiology (HP:0011840)2.15596932
80Genital tract atresia (HP:0001827)2.15546652
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15017062
82Bronchiectasis (HP:0002110)2.14693763
83Optic nerve coloboma (HP:0000588)2.13718293
84Abnormality of the preputium (HP:0100587)2.13703591
85Viral hepatitis (HP:0006562)2.12291942
86Spondylolisthesis (HP:0003302)2.12024000
87Volvulus (HP:0002580)2.11517005
88Abnormality of chromosome stability (HP:0003220)2.11362551
89Attenuation of retinal blood vessels (HP:0007843)2.10853231
90Ependymoma (HP:0002888)2.10536993
9111 pairs of ribs (HP:0000878)2.10245053
92B lymphocytopenia (HP:0010976)2.10025048
93Abnormality of B cell number (HP:0010975)2.10025048
94Vaginal atresia (HP:0000148)2.08860940
95Cystic liver disease (HP:0006706)2.08755889
96Recurrent fungal infections (HP:0002841)2.08641866
97Chromsome breakage (HP:0040012)2.08492962
98Decreased central vision (HP:0007663)2.07479559
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.04045954
100Recurrent cutaneous fungal infections (HP:0011370)2.03617219
101Chronic mucocutaneous candidiasis (HP:0002728)2.03617219
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.03281925
103Neoplasm of the colon (HP:0100273)2.02960385
104Osteomyelitis (HP:0002754)2.02643336
105Aplasia/Hypoplasia of the uvula (HP:0010293)2.02356075
106Inability to walk (HP:0002540)2.00606900
107Abnormal biliary tract physiology (HP:0012439)2.00417862
108Bile duct proliferation (HP:0001408)2.00417862
109Disproportionate short-trunk short stature (HP:0003521)1.99974543
110Basal cell carcinoma (HP:0002671)1.97038319
111Postaxial foot polydactyly (HP:0001830)1.95381357
112Premature graying of hair (HP:0002216)1.95047813
113Reduced antithrombin III activity (HP:0001976)1.94867828
114Neoplasm of the rectum (HP:0100743)1.93541645
115Methylmalonic acidemia (HP:0002912)1.92966575
116Increased density of long bones (HP:0006392)1.91521288
117Duodenal stenosis (HP:0100867)1.91185077
118Small intestinal stenosis (HP:0012848)1.91185077
119Hematochezia (HP:0002573)1.90196496
120Cutaneous melanoma (HP:0012056)1.89515083
121Cervical subluxation (HP:0003308)1.89504559
122Sclerocornea (HP:0000647)1.89434759
123Abnormality of the frontal sinuses (HP:0002687)1.88853697
124Pancreatic islet-cell hyperplasia (HP:0004510)1.87598097
125Entropion (HP:0000621)1.87124551
126Gastrointestinal carcinoma (HP:0002672)1.86837338
127Malignant gastrointestinal tract tumors (HP:0006749)1.86837338
128Sloping forehead (HP:0000340)1.86420999
129Medulloblastoma (HP:0002885)1.85987803
130Abnormality of macular pigmentation (HP:0008002)1.84997232
131Overlapping toe (HP:0001845)1.84907124
132Abnormality of T cells (HP:0002843)1.84892073
133Tubulointerstitial nephritis (HP:0001970)1.84508511
134Tubular atrophy (HP:0000092)1.83652793
135Neoplasm of the adrenal gland (HP:0100631)1.83587921
136Cellulitis (HP:0100658)1.83237858
137Abnormality of the fingertips (HP:0001211)1.82591831
138Deviation of the thumb (HP:0009603)1.82419785
139Abnormality of the pancreatic islet cells (HP:0006476)1.82199397
140Abnormality of endocrine pancreas physiology (HP:0012093)1.82199397
141Postaxial hand polydactyly (HP:0001162)1.81659328
142Abnormal glycosylation (HP:0012345)1.81304522
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81304522
144Abnormal protein N-linked glycosylation (HP:0012347)1.81304522
145Abnormal protein glycosylation (HP:0012346)1.81304522
146Abnormal biliary tract morphology (HP:0012440)1.80444303
147Bone marrow hypocellularity (HP:0005528)1.79715623
148Congenital hepatic fibrosis (HP:0002612)1.79204253
149Breast hypoplasia (HP:0003187)1.78759433
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.78738584
151Hypoplasia of the fovea (HP:0007750)1.78738584
152Abnormality of the ileum (HP:0001549)1.78494221
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.78142312
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.78097558
155Abnormal hair laboratory examination (HP:0003328)1.78055746
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.75456833
157Broad palm (HP:0001169)1.74264124
158Lymphopenia (HP:0001888)1.73633241
159Proximal placement of thumb (HP:0009623)1.73575169
160Teleangiectasia of the skin (HP:0100585)1.73517395
161Ovarian neoplasm (HP:0100615)1.72896129
162Abnormal trabecular bone morphology (HP:0100671)1.72101601
163Myositis (HP:0100614)1.72088875
164Rhabdomyosarcoma (HP:0002859)1.71749642
165Hypoglycemic coma (HP:0001325)1.71696742
166Preaxial hand polydactyly (HP:0001177)1.71170051
167Male pseudohermaphroditism (HP:0000037)1.71046661
168Aortic regurgitation (HP:0001659)1.70972650
169Meckel diverticulum (HP:0002245)1.70946367
170Gaze-evoked nystagmus (HP:0000640)1.70173726
171Abnormality of vitamin B metabolism (HP:0004340)1.69655868
172Ketoacidosis (HP:0001993)1.69465569
173Conjunctival hamartoma (HP:0100780)1.69408175
174Methylmalonic aciduria (HP:0012120)1.69215061
175Abnormality of the fovea (HP:0000493)1.67756460
176Poor coordination (HP:0002370)1.66903548
177Adrenal hypoplasia (HP:0000835)1.66527732
178Fair hair (HP:0002286)1.65355732
179Glioma (HP:0009733)1.65283012
180Astrocytoma (HP:0009592)1.63470614
181Abnormality of the astrocytes (HP:0100707)1.63470614
182Polydipsia (HP:0001959)1.62906603
183Abnormal drinking behavior (HP:0030082)1.62906603
184Anencephaly (HP:0002323)1.62277708
185Bilateral microphthalmos (HP:0007633)1.62024924
186Erythroderma (HP:0001019)1.61892262
187Chronic sinusitis (HP:0011109)1.61761829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.69449401
2MAP4K23.56966569
3TRIM282.82321399
4SCYL22.49587422
5STK102.47652933
6WEE12.38463677
7EEF2K2.33458338
8WNK32.27732698
9MAP4K12.15891499
10NUAK12.10402500
11NEK22.08818522
12BMPR1B2.03955825
13ACVR1B2.02224926
14FRK2.02178043
15PIM22.00144824
16RPS6KB21.98434575
17EIF2AK11.92047424
18BCR1.89231390
19MST41.82367779
20INSRR1.80867003
21GRK11.80754634
22TNIK1.79719462
23MAP3K41.78227032
24BRSK21.75561976
25FGFR21.70276612
26RPS6KA41.68120761
27BUB11.68090877
28AURKB1.62896679
29TEC1.61250580
30FLT31.61077695
31CASK1.61030577
32VRK11.60969281
33VRK21.58694166
34PASK1.57954497
35PIK3CA1.56313442
36ADRBK21.55564413
37OXSR11.51510672
38MAPKAPK31.46042780
39TGFBR11.42909029
40ATR1.42009081
41MKNK11.41730137
42DYRK31.41465169
43CDK81.41294418
44NEK11.39259445
45MAP3K81.39135356
46ERBB31.38232534
47PLK31.37437375
48MAP2K71.37223619
49STK31.35507295
50STK391.33179211
51PLK11.33057414
52STK38L1.31361520
53LRRK21.30204479
54PLK21.30148691
55TESK11.27317530
56TSSK61.26545021
57CSNK1G31.24450497
58TTK1.23614730
59EIF2AK31.23311973
60CSNK1G11.21945120
61JAK31.20308556
62CHEK21.19868958
63CDK41.19787277
64CSNK1G21.19269416
65BTK1.18713090
66PIM11.17944247
67MELK1.17656171
68PLK41.15715901
69RAF11.14890993
70BRSK11.14589753
71CCNB11.12832767
72CDK61.12570814
73NME21.12325968
74PINK11.10011804
75CDK71.09601465
76PKN21.09262173
77MAP3K121.08854194
78BRD41.07660300
79MAP3K141.06771393
80YES11.06715616
81TXK1.06586319
82PAK41.05015536
83MAP3K101.03399281
84ITK1.02778477
85MAPK131.01139671
86CSNK1A1L1.01072248
87SRPK11.00225354
88GRK60.99488005
89ZAP700.99316434
90RIPK10.97622735
91NLK0.97050556
92WNK40.96794342
93RIPK40.95240582
94KIT0.94798268
95CHEK10.93336098
96TRPM70.92408040
97TIE10.91935948
98ZAK0.91783247
99EPHA20.90002645
100PRKCE0.88419543
101TLK10.83566129
102TAOK20.83523629
103BLK0.83366804
104PRKCI0.81393374
105TAF10.79458848
106FER0.77532615
107TYK20.76093270
108SYK0.75285524
109AURKA0.73200006
110TESK20.70602549
111CHUK0.68513321
112EIF2AK20.67938133
113CDK90.67870187
114NME10.66860716
115CSF1R0.65277809
116CLK10.65187904
117MAP3K130.63494259
118ATM0.62848025
119MARK30.60362303
120PAK30.59922865
121DAPK10.59423876
122LIMK10.55501541
123CDK20.54039909
124PAK10.52967785
125MAP3K110.51692079
126CDK120.51503313
127TBK10.51325587
128TAOK30.50803025
129CAMKK20.50508672
130LYN0.49609071
131PRKCG0.48973835
132PBK0.48277791
133CSNK2A20.48218448
134BRAF0.48101161
135MKNK20.47779250
136IKBKB0.47338262
137MAP2K30.47190702
138SIK30.45800366
139ALK0.45263426
140STK240.44945737
141MATK0.44889847
142PAK20.43861443
143PNCK0.43520693
144MAP3K30.43308890
145LCK0.42657073
146STK160.41134617
147DYRK20.40837142
148EPHA40.38364215
149EGFR0.36290595
150DAPK20.34723179
151PTK2B0.33939518
152CSNK1A10.33342773
153ABL10.31294136
154ADRBK10.30926404
155PHKG20.29715417
156PHKG10.29715417
157RPS6KA50.29065148
158MAPKAPK50.29058386
159NTRK30.28231925
160IGF1R0.28163863
161BMPR20.26705555
162CSNK1D0.26173473
163FGFR10.25897201

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46172332
2Mismatch repair_Homo sapiens_hsa034303.58852154
3Base excision repair_Homo sapiens_hsa034102.87485126
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79586694
5Protein export_Homo sapiens_hsa030602.78299703
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.68078855
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64411905
8Cell cycle_Homo sapiens_hsa041102.51689517
9Non-homologous end-joining_Homo sapiens_hsa034502.40858360
10Spliceosome_Homo sapiens_hsa030402.39560898
11Homologous recombination_Homo sapiens_hsa034402.39428164
12RNA transport_Homo sapiens_hsa030132.38836704
13Ribosome_Homo sapiens_hsa030102.32507963
14Nucleotide excision repair_Homo sapiens_hsa034202.24774384
15Butanoate metabolism_Homo sapiens_hsa006502.19628257
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08845675
17Selenocompound metabolism_Homo sapiens_hsa004502.08201310
18Proteasome_Homo sapiens_hsa030502.02249977
19Phototransduction_Homo sapiens_hsa047442.00284712
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99286411
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95580191
22p53 signaling pathway_Homo sapiens_hsa041151.94205652
23RNA degradation_Homo sapiens_hsa030181.75352411
24Primary immunodeficiency_Homo sapiens_hsa053401.73821783
25Pyrimidine metabolism_Homo sapiens_hsa002401.73060466
26Sulfur metabolism_Homo sapiens_hsa009201.70518701
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70212961
28Antigen processing and presentation_Homo sapiens_hsa046121.67015672
29RNA polymerase_Homo sapiens_hsa030201.62873246
30One carbon pool by folate_Homo sapiens_hsa006701.55845026
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53051504
32Propanoate metabolism_Homo sapiens_hsa006401.46269499
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44788532
34Fanconi anemia pathway_Homo sapiens_hsa034601.43427117
35Fatty acid elongation_Homo sapiens_hsa000621.32291599
36N-Glycan biosynthesis_Homo sapiens_hsa005101.29564306
37Basal transcription factors_Homo sapiens_hsa030221.29364692
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26386671
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24563720
40Herpes simplex infection_Homo sapiens_hsa051681.23934498
41Thyroid cancer_Homo sapiens_hsa052161.19171644
42Taste transduction_Homo sapiens_hsa047421.18136998
43Legionellosis_Homo sapiens_hsa051341.17843246
44Steroid biosynthesis_Homo sapiens_hsa001001.17312159
45Regulation of autophagy_Homo sapiens_hsa041401.16942053
46Hematopoietic cell lineage_Homo sapiens_hsa046401.16396561
47Ether lipid metabolism_Homo sapiens_hsa005651.15758531
48Nicotine addiction_Homo sapiens_hsa050331.15755115
49Systemic lupus erythematosus_Homo sapiens_hsa053221.14169339
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13387625
51Hepatitis B_Homo sapiens_hsa051611.11525176
52Chronic myeloid leukemia_Homo sapiens_hsa052201.11110972
53Epstein-Barr virus infection_Homo sapiens_hsa051691.10779256
54Viral carcinogenesis_Homo sapiens_hsa052031.08893086
55Peroxisome_Homo sapiens_hsa041461.07276503
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.05534931
57Oxidative phosphorylation_Homo sapiens_hsa001901.04686859
58mRNA surveillance pathway_Homo sapiens_hsa030151.04572407
59Linoleic acid metabolism_Homo sapiens_hsa005911.04523604
60Leishmaniasis_Homo sapiens_hsa051401.03833818
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02618414
62Shigellosis_Homo sapiens_hsa051311.02536839
63Small cell lung cancer_Homo sapiens_hsa052221.00812584
64B cell receptor signaling pathway_Homo sapiens_hsa046621.00425064
65Colorectal cancer_Homo sapiens_hsa052100.99275903
66Apoptosis_Homo sapiens_hsa042100.98684539
67Chemical carcinogenesis_Homo sapiens_hsa052040.97106953
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94041050
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92728403
70Retinol metabolism_Homo sapiens_hsa008300.92121518
71Olfactory transduction_Homo sapiens_hsa047400.91409665
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89890591
73Measles_Homo sapiens_hsa051620.88513424
74HTLV-I infection_Homo sapiens_hsa051660.88260137
75Purine metabolism_Homo sapiens_hsa002300.82984947
76Nitrogen metabolism_Homo sapiens_hsa009100.81996263
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81783127
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81211778
79Type I diabetes mellitus_Homo sapiens_hsa049400.80798841
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80164143
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.79821829
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79724982
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.78347686
84Oocyte meiosis_Homo sapiens_hsa041140.78077878
85Caffeine metabolism_Homo sapiens_hsa002320.78007236
86Pancreatic cancer_Homo sapiens_hsa052120.77997835
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77830013
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76722598
89Influenza A_Homo sapiens_hsa051640.76282873
90Parkinsons disease_Homo sapiens_hsa050120.75878994
91Viral myocarditis_Homo sapiens_hsa054160.75495977
92Tryptophan metabolism_Homo sapiens_hsa003800.74337913
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73735516
94MicroRNAs in cancer_Homo sapiens_hsa052060.73638470
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73471111
96Huntingtons disease_Homo sapiens_hsa050160.71043201
97Salmonella infection_Homo sapiens_hsa051320.70736278
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70175150
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70143850
100Serotonergic synapse_Homo sapiens_hsa047260.69264506
101Toxoplasmosis_Homo sapiens_hsa051450.68900282
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68454761
103Pertussis_Homo sapiens_hsa051330.66094530
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65515871
105Renin-angiotensin system_Homo sapiens_hsa046140.65248499
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64783520
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64167651
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64018576
109Metabolic pathways_Homo sapiens_hsa011000.63904316
110T cell receptor signaling pathway_Homo sapiens_hsa046600.63867808
111Glutathione metabolism_Homo sapiens_hsa004800.63301281
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63089289
113Osteoclast differentiation_Homo sapiens_hsa043800.62895326
114Vitamin digestion and absorption_Homo sapiens_hsa049770.62415269
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.61412987
116Acute myeloid leukemia_Homo sapiens_hsa052210.60101605
117TGF-beta signaling pathway_Homo sapiens_hsa043500.60045751
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.59764866
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59742476
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58858858
121Alcoholism_Homo sapiens_hsa050340.58628839
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58364120
123Sphingolipid metabolism_Homo sapiens_hsa006000.57710696
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.57208943
125Circadian entrainment_Homo sapiens_hsa047130.55409453
126Morphine addiction_Homo sapiens_hsa050320.54073480
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.53851492
128GABAergic synapse_Homo sapiens_hsa047270.52452692
129Fatty acid metabolism_Homo sapiens_hsa012120.52354220
130Collecting duct acid secretion_Homo sapiens_hsa049660.50352289
131Bladder cancer_Homo sapiens_hsa052190.50238465
132Circadian rhythm_Homo sapiens_hsa047100.49945427
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49158764
134Tuberculosis_Homo sapiens_hsa051520.48655495
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47415287
136Non-small cell lung cancer_Homo sapiens_hsa052230.45943445
137Hedgehog signaling pathway_Homo sapiens_hsa043400.43775029
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.43691974
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40439958
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39069322
141Pentose phosphate pathway_Homo sapiens_hsa000300.38651005
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37947558
143Glycerolipid metabolism_Homo sapiens_hsa005610.37830679
144Fatty acid degradation_Homo sapiens_hsa000710.37406104
145Dopaminergic synapse_Homo sapiens_hsa047280.36955090
146Salivary secretion_Homo sapiens_hsa049700.36869867
147TNF signaling pathway_Homo sapiens_hsa046680.36490522
148HIF-1 signaling pathway_Homo sapiens_hsa040660.36462528
149Insulin secretion_Homo sapiens_hsa049110.36393345
150Platelet activation_Homo sapiens_hsa046110.35806785
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35174241
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35152566
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.34138966
154Adherens junction_Homo sapiens_hsa045200.33609142
155Pathways in cancer_Homo sapiens_hsa052000.33588389
156Hepatitis C_Homo sapiens_hsa051600.31992703
157beta-Alanine metabolism_Homo sapiens_hsa004100.31833187
158Asthma_Homo sapiens_hsa053100.31611951
159Galactose metabolism_Homo sapiens_hsa000520.31360959
160Glutamatergic synapse_Homo sapiens_hsa047240.30164315
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.29274398
162Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25944618
163Prostate cancer_Homo sapiens_hsa052150.25827362
164AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25642416

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