ZDHHC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.77904487
2doxorubicin metabolic process (GO:0044598)6.77904487
3daunorubicin metabolic process (GO:0044597)6.77904487
4protein localization to kinetochore (GO:0034501)6.19554685
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.44321738
6negative regulation of cell cycle G2/M phase transition (GO:1902750)5.17327273
7mitotic sister chromatid segregation (GO:0000070)4.95030735
8regulation of telomere maintenance via telomerase (GO:0032210)4.85038792
9negative regulation of epidermis development (GO:0045683)4.83683467
10maintenance of protein location in nucleus (GO:0051457)4.74805460
11regulation of nuclear cell cycle DNA replication (GO:0033262)4.70527909
12somite rostral/caudal axis specification (GO:0032525)4.67041598
13nuclear pore complex assembly (GO:0051292)4.64268656
14negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.63397916
15protein localization to chromosome, centromeric region (GO:0071459)4.62090059
16regulation of mammary gland epithelial cell proliferation (GO:0033599)4.56843508
17sister chromatid segregation (GO:0000819)4.55500732
18behavioral response to nicotine (GO:0035095)4.53659626
19histone H4-K5 acetylation (GO:0043981)4.52729679
20histone H4-K8 acetylation (GO:0043982)4.52729679
21interferon-gamma production (GO:0032609)4.40824878
22histone H4-K12 acetylation (GO:0043983)4.38942356
23DNA replication-dependent nucleosome organization (GO:0034723)4.38124422
24DNA replication-dependent nucleosome assembly (GO:0006335)4.38124422
25DNA unwinding involved in DNA replication (GO:0006268)4.33566758
26pre-miRNA processing (GO:0031054)4.28798417
27nuclear pore organization (GO:0006999)4.24073340
28positive regulation of DNA-dependent DNA replication (GO:2000105)4.21097681
29regulation of MHC class I biosynthetic process (GO:0045343)4.20168954
30DNA replication checkpoint (GO:0000076)4.15259748
31heterochromatin organization (GO:0070828)4.12232249
32aminoglycoside antibiotic metabolic process (GO:0030647)4.09764445
33negative regulation of telomerase activity (GO:0051974)4.06217511
34mitotic chromosome condensation (GO:0007076)3.98557967
35notochord development (GO:0030903)3.98400095
36indole-containing compound catabolic process (GO:0042436)3.96501677
37indolalkylamine catabolic process (GO:0046218)3.96501677
38tryptophan catabolic process (GO:0006569)3.96501677
39muscle organ morphogenesis (GO:0048644)3.96024061
40indolalkylamine metabolic process (GO:0006586)3.84883273
41gamma-aminobutyric acid transport (GO:0015812)3.75348008
42kynurenine metabolic process (GO:0070189)3.74828008
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.74720855
44regulation of response to osmotic stress (GO:0047484)3.73244841
45neural tube formation (GO:0001841)3.71442624
46negative regulation of epidermal cell differentiation (GO:0045605)3.67428875
47chromatin assembly (GO:0031497)3.64305595
48rRNA transcription (GO:0009303)3.63759774
49response to pheromone (GO:0019236)3.63508298
50histone H4-K16 acetylation (GO:0043984)3.63262913
51DNA duplex unwinding (GO:0032508)3.56103374
52DNA geometric change (GO:0032392)3.54612468
53L-fucose catabolic process (GO:0042355)3.45997039
54fucose catabolic process (GO:0019317)3.45997039
55L-fucose metabolic process (GO:0042354)3.45997039
56presynaptic membrane assembly (GO:0097105)3.45255460
57pyrimidine nucleobase catabolic process (GO:0006208)3.45078444
58detection of light stimulus involved in sensory perception (GO:0050962)3.44364519
59detection of light stimulus involved in visual perception (GO:0050908)3.44364519
60DNA replication initiation (GO:0006270)3.43801974
61pore complex assembly (GO:0046931)3.42395907
62tryptophan metabolic process (GO:0006568)3.41615784
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36610515
64regulation of translation in response to stress (GO:0043555)3.31332995
65phenol-containing compound catabolic process (GO:0019336)3.25703578
66epithelial cilium movement (GO:0003351)3.23825713
67regulation of telomere maintenance (GO:0032204)3.23150902
68cilium or flagellum-dependent cell motility (GO:0001539)3.22272092
69reflex (GO:0060004)3.18734727
70primitive streak formation (GO:0090009)3.17787716
71photoreceptor cell maintenance (GO:0045494)3.16299913
72transmission of nerve impulse (GO:0019226)3.11470951
73regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.11045195
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10269036
75regulation of posttranscriptional gene silencing (GO:0060147)3.09784110
76regulation of gene silencing by miRNA (GO:0060964)3.09784110
77regulation of gene silencing by RNA (GO:0060966)3.09784110
78mitotic nuclear envelope disassembly (GO:0007077)3.09298051
79cilium morphogenesis (GO:0060271)3.07888186
80behavioral response to ethanol (GO:0048149)3.05859176
81cullin deneddylation (GO:0010388)3.05779840
82protein K11-linked deubiquitination (GO:0035871)3.05541484
83presynaptic membrane organization (GO:0097090)3.05202036
84DNA double-strand break processing (GO:0000729)3.05060486
85RNA stabilization (GO:0043489)3.04957424
86mRNA stabilization (GO:0048255)3.04957424
87protein polyglutamylation (GO:0018095)3.04061890
88platelet dense granule organization (GO:0060155)3.02984533
89negative regulation of telomere maintenance (GO:0032205)3.02930094
90regulation of helicase activity (GO:0051095)3.01734143
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99531851
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99521910
93nucleobase catabolic process (GO:0046113)2.98053537
94regulation of double-strand break repair (GO:2000779)2.96872943
95cellular protein complex localization (GO:0034629)2.96427947
96membrane disassembly (GO:0030397)2.95903442
97nuclear envelope disassembly (GO:0051081)2.95903442
98retinal cone cell development (GO:0046549)2.95839948
99axoneme assembly (GO:0035082)2.94372657
100formation of translation preinitiation complex (GO:0001731)2.93084815
101water-soluble vitamin biosynthetic process (GO:0042364)2.92775016
102regulation of telomerase activity (GO:0051972)2.92531228
103nonmotile primary cilium assembly (GO:0035058)2.92234509
104rRNA methylation (GO:0031167)2.91950422
105protein localization to cilium (GO:0061512)2.91721018
106indole-containing compound metabolic process (GO:0042430)2.91182138
107cellular ketone body metabolic process (GO:0046950)2.90046605
108chromosome condensation (GO:0030261)2.89034375
109cilium organization (GO:0044782)2.88314474
110DNA damage response, detection of DNA damage (GO:0042769)2.88061834
111DNA conformation change (GO:0071103)2.87468671
112centriole replication (GO:0007099)2.86838042
113somite development (GO:0061053)2.86517490
114protein prenylation (GO:0018342)2.85840148
115prenylation (GO:0097354)2.85840148
116sulfation (GO:0051923)2.84784322
117cilium movement (GO:0003341)2.84672820
118regulation of collateral sprouting (GO:0048670)2.83219430
119cilium assembly (GO:0042384)2.82901349
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82317811
121neuronal action potential (GO:0019228)2.82106562
122intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.81955865
123regulation of action potential (GO:0098900)2.77894086
124regulation of histone H3-K9 methylation (GO:0051570)2.76835162
125inner ear receptor stereocilium organization (GO:0060122)2.76514013
126branching involved in mammary gland duct morphogenesis (GO:0060444)2.75586594
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74969574
128attachment of spindle microtubules to kinetochore (GO:0008608)2.74780063
129rRNA modification (GO:0000154)2.74274690
130replication fork processing (GO:0031297)2.74041084
131cell fate commitment involved in formation of primary germ layer (GO:0060795)2.73415770
132positive regulation of protein deacetylation (GO:0090312)2.70163820
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70154719
134maintenance of protein localization in organelle (GO:0072595)2.69596816
135regulation of sarcomere organization (GO:0060297)2.69054611
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68853954
137DNA strand elongation involved in DNA replication (GO:0006271)2.68770448
138cytidine deamination (GO:0009972)2.68662920
139cytidine metabolic process (GO:0046087)2.68662920
140cytidine catabolic process (GO:0006216)2.68662920
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.68129222
142negative regulation of mast cell activation (GO:0033004)2.67709011
143auditory receptor cell stereocilium organization (GO:0060088)2.67389364
144postsynaptic membrane organization (GO:0001941)2.66343561
145mitotic G2/M transition checkpoint (GO:0044818)2.66261209
146negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.66236496
147neuronal action potential propagation (GO:0019227)2.66053211
148piRNA metabolic process (GO:0034587)2.65969112
149protein localization to chromosome (GO:0034502)2.65965542
150kidney morphogenesis (GO:0060993)2.65612544
151recombinational repair (GO:0000725)2.65304642
152regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.64644175
153ketone body metabolic process (GO:1902224)2.64167664
154double-strand break repair via homologous recombination (GO:0000724)2.64133458
155intraciliary transport (GO:0042073)2.63855311
156regulation of gene silencing (GO:0060968)2.63697254
157bone trabecula formation (GO:0060346)2.63347273
158spindle assembly (GO:0051225)2.63173528
159reciprocal DNA recombination (GO:0035825)2.62848722
160reciprocal meiotic recombination (GO:0007131)2.62848722
161protein deneddylation (GO:0000338)2.62104609
162photoreceptor cell development (GO:0042461)2.61831859
163startle response (GO:0001964)2.61761163
164spindle assembly checkpoint (GO:0071173)2.61263365
165histone arginine methylation (GO:0034969)2.61124765
166DNA strand renaturation (GO:0000733)2.60919216
167signal peptide processing (GO:0006465)2.60883112
168positive regulation of oligodendrocyte differentiation (GO:0048714)2.60509892
169regulation of DNA-dependent DNA replication (GO:0090329)2.58923457
170DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58921586
171anterior/posterior axis specification (GO:0009948)2.58831912
172chromatin assembly or disassembly (GO:0006333)2.58425428
173cellular response to sterol (GO:0036315)2.57304193
174regulation of hippo signaling (GO:0035330)2.56027882
175amine catabolic process (GO:0009310)2.54714256
176cellular biogenic amine catabolic process (GO:0042402)2.54714256
177tachykinin receptor signaling pathway (GO:0007217)2.54437039
178regulation of cilium movement (GO:0003352)2.54180873
179establishment of protein localization to Golgi (GO:0072600)2.54138715
180proline transport (GO:0015824)2.53948851
181negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53640224
182negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53399212
183negative regulation of translation, ncRNA-mediated (GO:0040033)2.53399212
184regulation of translation, ncRNA-mediated (GO:0045974)2.53399212
185mitochondrial respiratory chain complex I assembly (GO:0032981)2.53183346
186NADH dehydrogenase complex assembly (GO:0010257)2.53183346
187mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53183346
188benzene-containing compound metabolic process (GO:0042537)2.53026919
189regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52493089
190protein complex biogenesis (GO:0070271)2.52458172
191neuron cell-cell adhesion (GO:0007158)2.51398803
192thyroid hormone metabolic process (GO:0042403)2.50676855
193limb bud formation (GO:0060174)2.49710801
194glycosphingolipid biosynthetic process (GO:0006688)2.48715984
195central nervous system neuron axonogenesis (GO:0021955)2.47835879
196seminiferous tubule development (GO:0072520)2.47586955
197rhodopsin mediated signaling pathway (GO:0016056)2.45062583
198membrane depolarization during action potential (GO:0086010)2.44284806
199dopamine transport (GO:0015872)2.43585482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.52695082
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.95740803
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.95740803
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.95740803
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.37070306
6E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05902879
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.57516195
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.55775561
9GBX2_23144817_ChIP-Seq_PC3_Human3.53335709
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37381401
11ZNF274_21170338_ChIP-Seq_K562_Hela3.20917525
12EZH2_22144423_ChIP-Seq_EOC_Human3.16821702
13IGF1R_20145208_ChIP-Seq_DFB_Human2.97565886
14VDR_22108803_ChIP-Seq_LS180_Human2.96096645
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90207007
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85157251
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74326912
18TAF15_26573619_Chip-Seq_HEK293_Human2.59434611
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.56033007
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53453254
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51943961
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.42547127
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37598385
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36067153
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35116952
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34313745
27FUS_26573619_Chip-Seq_HEK293_Human2.32378950
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31387086
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.26349036
30P300_19829295_ChIP-Seq_ESCs_Human2.22577736
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.21907798
32EWS_26573619_Chip-Seq_HEK293_Human2.20593789
33FLI1_27457419_Chip-Seq_LIVER_Mouse2.19291933
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16000546
35TCF3_18692474_ChIP-Seq_MESCs_Mouse2.11871663
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10356477
37CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09793479
38TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08750892
39EGR1_19374776_ChIP-ChIP_THP-1_Human2.03479836
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95204489
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94278994
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93502872
43ER_23166858_ChIP-Seq_MCF-7_Human1.87496064
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86401006
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.82288525
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81730756
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81305759
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79394230
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78520094
50SMAD4_21799915_ChIP-Seq_A2780_Human1.76649065
51MYC_22102868_ChIP-Seq_BL_Human1.75968307
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.75671737
53STAT3_23295773_ChIP-Seq_U87_Human1.74288647
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71527339
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68962742
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68341828
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68260075
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67704983
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66540733
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61074164
61CBP_20019798_ChIP-Seq_JUKART_Human1.60219380
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60219380
63TCF4_23295773_ChIP-Seq_U87_Human1.59928145
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59260618
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58502862
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58320379
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.57923337
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57333009
69BCAT_22108803_ChIP-Seq_LS180_Human1.56726022
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56622181
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56183611
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56174422
73AR_25329375_ChIP-Seq_VCAP_Human1.54806935
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54773510
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.52936070
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49755729
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49380028
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47997364
79AR_21909140_ChIP-Seq_LNCAP_Human1.47275000
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47042068
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46728307
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45953690
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44842642
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44668719
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44285679
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42861864
87TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41955362
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41787504
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40740530
90TCF4_22108803_ChIP-Seq_LS180_Human1.38294468
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37860916
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37842307
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37634344
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37634344
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37543023
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.37386789
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.37213601
98REST_21632747_ChIP-Seq_MESCs_Mouse1.36647865
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36556486
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35002088
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.34873882
102AR_21572438_ChIP-Seq_LNCaP_Human1.34763311
103IRF1_19129219_ChIP-ChIP_H3396_Human1.34505553
104TP53_22573176_ChIP-Seq_HFKS_Human1.33864841
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32808698
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32203027
107RNF2_27304074_Chip-Seq_NSC_Mouse1.30536974
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30523150
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.29876399
110RUNX2_22187159_ChIP-Seq_PCA_Human1.29752537
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.29385505
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29200644
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29013553
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27053815
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.27012957
116SOX2_19829295_ChIP-Seq_ESCs_Human1.26902110
117NANOG_19829295_ChIP-Seq_ESCs_Human1.26902110
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.24580060
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23703460
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22757560
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22146033
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20817925
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.20808054
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.20516803
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.19848893
126E2F1_17053090_ChIP-ChIP_MCF-7_Human1.19343985
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19338606
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18409368
129XRN2_22483619_ChIP-Seq_HELA_Human1.17313506
130P53_22387025_ChIP-Seq_ESCs_Mouse1.16402963
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15564341
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.14565834
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12440980
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12356289
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.11504872
136NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11287008
137NANOG_16153702_ChIP-ChIP_HESCs_Human1.11195762
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11139305
139NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09841436
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09787838
141* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09250640
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08429352
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.07915799
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.07828695
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07828695
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07559886
147FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07198204
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06638482
149CDX2_22108803_ChIP-Seq_LS180_Human1.06197966
150TAL1_26923725_Chip-Seq_HPCs_Mouse1.05663425
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04987464
152FOXP3_21729870_ChIP-Seq_TREG_Human1.04186347
153JUN_21703547_ChIP-Seq_K562_Human1.04151195
154STAT3_18555785_Chip-Seq_ESCs_Mouse1.04020616
155KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04011823
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03756890
157POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03628534
158E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03251309
159OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02725437
160TTF2_22483619_ChIP-Seq_HELA_Human1.02414027
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01936785
162ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01930936
163SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00533436
164MYC_18940864_ChIP-ChIP_HL60_Human1.00479260
165NANOG_16518401_ChIP-PET_MESCs_Mouse1.00168331
166SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00109591
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.99785717
168KDM2B_26808549_Chip-Seq_REH_Human0.99364761
169POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98975236
170CIITA_25753668_ChIP-Seq_RAJI_Human0.98806844
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98590152
172OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98563178
173TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97910866
174SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95532509
175SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95202374
176* NANOG_21062744_ChIP-ChIP_HESCs_Human0.94017501
177SOX2_16153702_ChIP-ChIP_HESCs_Human0.93811433
178STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92900544
179RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91278193
180YY1_21170310_ChIP-Seq_MESCs_Mouse0.89110458
181TCF7_22412390_ChIP-Seq_EML_Mouse0.89108289
182ELK1_19687146_ChIP-ChIP_HELA_Human0.88748888
183YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87849758
184HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87797861
185WT1_19549856_ChIP-ChIP_CCG9911_Human0.86787289
186ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85986738
187MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85206290
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84532814
189WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84502021
190KDM5A_27292631_Chip-Seq_BREAST_Human0.84346178
191NCOR1_26117541_ChIP-Seq_K562_Human0.80402763
192TBX3_20139965_ChIP-Seq_ESCs_Mouse0.79819285
193TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79436047
194VDR_23849224_ChIP-Seq_CD4+_Human0.78335845
195TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78203471
196ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78112455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.09464790
2MP0008057_abnormal_DNA_replication4.05496792
3MP0004264_abnormal_extraembryonic_tissu3.38650785
4MP0003890_abnormal_embryonic-extraembry3.38034586
5MP0003121_genomic_imprinting3.21160975
6MP0004957_abnormal_blastocyst_morpholog3.12438952
7MP0006292_abnormal_olfactory_placode3.00659302
8MP0000569_abnormal_digit_pigmentation2.87050906
9MP0003123_paternal_imprinting2.73125303
10MP0008877_abnormal_DNA_methylation2.65267315
11MP0010352_gastrointestinal_tract_polyps2.63503381
12MP0002254_reproductive_system_inflammat2.60973144
13MP0005394_taste/olfaction_phenotype2.55142689
14MP0005499_abnormal_olfactory_system2.55142689
15MP0003195_calcinosis2.54884449
16MP0005551_abnormal_eye_electrophysiolog2.52501214
17MP0001968_abnormal_touch/_nociception2.50420842
18MP0005075_abnormal_melanosome_morpholog2.42835399
19MP0004858_abnormal_nervous_system2.41910829
20MP0002102_abnormal_ear_morphology2.41076345
21MP0003880_abnormal_central_pattern2.25646519
22MP0002736_abnormal_nociception_after2.24021972
23MP0009046_muscle_twitch2.23769202
24MP0003077_abnormal_cell_cycle2.17957205
25MP0005646_abnormal_pituitary_gland2.08341806
26MP0002837_dystrophic_cardiac_calcinosis2.02840910
27MP0009745_abnormal_behavioral_response2.02130407
28MP0003705_abnormal_hypodermis_morpholog2.01280820
29MP0010094_abnormal_chromosome_stability1.99164966
30MP0001984_abnormal_olfaction1.96288093
31MP0001986_abnormal_taste_sensitivity1.94303035
32* MP0001672_abnormal_embryogenesis/_devel1.87300103
33* MP0005380_embryogenesis_phenotype1.87300103
34MP0003011_delayed_dark_adaptation1.85467043
35MP0002653_abnormal_ependyma_morphology1.82718319
36MP0001486_abnormal_startle_reflex1.81161739
37MP0003787_abnormal_imprinting1.80976121
38MP0006276_abnormal_autonomic_nervous1.80664973
39MP0001485_abnormal_pinna_reflex1.79769282
40MP0002272_abnormal_nervous_system1.79604790
41MP0001348_abnormal_lacrimal_gland1.78910602
42MP0002396_abnormal_hematopoietic_system1.78579313
43MP0010030_abnormal_orbit_morphology1.77910226
44MP0001501_abnormal_sleep_pattern1.72155927
45* MP0002088_abnormal_embryonic_growth/wei1.72067126
46* MP0003984_embryonic_growth_retardation1.71064436
47MP0005253_abnormal_eye_physiology1.69938454
48MP0004142_abnormal_muscle_tone1.67985701
49MP0002735_abnormal_chemical_nociception1.67626643
50MP0000350_abnormal_cell_proliferation1.67127613
51MP0008872_abnormal_physiological_respon1.66990436
52MP0000631_abnormal_neuroendocrine_gland1.65533887
53MP0003111_abnormal_nucleus_morphology1.65528587
54MP0001529_abnormal_vocalization1.63926100
55MP0002932_abnormal_joint_morphology1.63899539
56MP0000049_abnormal_middle_ear1.63290167
57MP0003136_yellow_coat_color1.62114881
58MP0006072_abnormal_retinal_apoptosis1.58907063
59MP0008932_abnormal_embryonic_tissue1.58749219
60MP0002876_abnormal_thyroid_physiology1.58413414
61MP0000678_abnormal_parathyroid_gland1.54798748
62MP0003315_abnormal_perineum_morphology1.54790106
63MP0002638_abnormal_pupillary_reflex1.54745328
64MP0002332_abnormal_exercise_endurance1.52373510
65MP0002086_abnormal_extraembryonic_tissu1.50323897
66* MP0002085_abnormal_embryonic_tissue1.48777599
67MP0003119_abnormal_digestive_system1.48582667
68MP0003635_abnormal_synaptic_transmissio1.46689787
69MP0004145_abnormal_muscle_electrophysio1.46537081
70MP0002064_seizures1.46465113
71MP0004043_abnormal_pH_regulation1.45089433
72MP0002572_abnormal_emotion/affect_behav1.44622739
73MP0002938_white_spotting1.44222602
74MP0005645_abnormal_hypothalamus_physiol1.44006157
75MP0001293_anophthalmia1.43875586
76MP0000778_abnormal_nervous_system1.42982018
77MP0002084_abnormal_developmental_patter1.42250548
78MP0004270_analgesia1.40871526
79MP0002734_abnormal_mechanical_nocicepti1.39908528
80MP0001970_abnormal_pain_threshold1.38777649
81MP0001849_ear_inflammation1.38571879
82MP0000427_abnormal_hair_cycle1.38151885
83MP0002127_abnormal_cardiovascular_syste1.37650192
84MP0003938_abnormal_ear_development1.33405204
85MP0003646_muscle_fatigue1.32732541
86MP0004885_abnormal_endolymph1.31146014
87MP0001730_embryonic_growth_arrest1.31114579
88MP0002557_abnormal_social/conspecific_i1.30132080
89MP0005174_abnormal_tail_pigmentation1.29915799
90MP0004197_abnormal_fetal_growth/weight/1.29366663
91MP0002733_abnormal_thermal_nociception1.28796028
92MP0005187_abnormal_penis_morphology1.28177551
93MP0004215_abnormal_myocardial_fiber1.28110557
94MP0005386_behavior/neurological_phenoty1.28083231
95MP0004924_abnormal_behavior1.28083231
96MP0003693_abnormal_embryo_hatching1.27348033
97MP0002067_abnormal_sensory_capabilities1.25752097
98MP0002063_abnormal_learning/memory/cond1.24897785
99MP0008789_abnormal_olfactory_epithelium1.23954344
100MP0001697_abnormal_embryo_size1.23939691
101MP0002928_abnormal_bile_duct1.21759452
102MP0003935_abnormal_craniofacial_develop1.19579189
103MP0010386_abnormal_urinary_bladder1.14326281
104MP0008058_abnormal_DNA_repair1.13721291
105MP0002751_abnormal_autonomic_nervous1.13450878
106MP0008007_abnormal_cellular_replicative1.13407529
107MP0002114_abnormal_axial_skeleton1.11710138
108MP0003755_abnormal_palate_morphology1.11053305
109MP0002080_prenatal_lethality1.10663479
110MP0000428_abnormal_craniofacial_morphol1.10249100
111MP0005379_endocrine/exocrine_gland_phen1.10072201
112MP0003937_abnormal_limbs/digits/tail_de1.09525762
113MP0002092_abnormal_eye_morphology1.08085788
114MP0004133_heterotaxia1.07778522
115MP0005389_reproductive_system_phenotype1.07381974
116MP0004147_increased_porphyrin_level1.07184853
117MP0002925_abnormal_cardiovascular_devel1.06881957
118MP0002233_abnormal_nose_morphology1.06340470
119MP0005084_abnormal_gallbladder_morpholo1.05971256
120MP0003183_abnormal_peptide_metabolism1.05626272
121MP0002160_abnormal_reproductive_system1.05302587
122MP0002163_abnormal_gland_morphology1.02994570
123MP0008875_abnormal_xenobiotic_pharmacok1.02239558
124MP0005195_abnormal_posterior_eye1.01662572
125MP0008770_decreased_survivor_rate1.01500773
126MP0000762_abnormal_tongue_morphology1.01080120
127MP0000432_abnormal_head_morphology1.00751900
128MP0002752_abnormal_somatic_nervous1.00126657
129MP0002234_abnormal_pharynx_morphology0.99460690
130MP0008961_abnormal_basal_metabolism0.97851658
131MP0000383_abnormal_hair_follicle0.97711273
132MP0002184_abnormal_innervation0.97013566
133MP0004859_abnormal_synaptic_plasticity0.95949944
134MP0003763_abnormal_thymus_physiology0.95096160
135MP0003718_maternal_effect0.95003549
136MP0004742_abnormal_vestibular_system0.93347608
137MP0003942_abnormal_urinary_system0.92194389
138MP0002229_neurodegeneration0.91341319
139MP0000490_abnormal_crypts_of0.90789233
140MP0002095_abnormal_skin_pigmentation0.90573460
141MP0000647_abnormal_sebaceous_gland0.90117191
142MP0002277_abnormal_respiratory_mucosa0.89881144
143MP0003698_abnormal_male_reproductive0.89113301
144MP0005257_abnormal_intraocular_pressure0.88677576
145MP0004272_abnormal_basement_membrane0.88597485
146MP0002882_abnormal_neuron_morphology0.88337963
147MP0000313_abnormal_cell_death0.87968000
148MP0010368_abnormal_lymphatic_system0.87766923
149MP0001963_abnormal_hearing_physiology0.87627329
150MP0006035_abnormal_mitochondrial_morpho0.87591214
151MP0008995_early_reproductive_senescence0.86835440
152MP0005171_absent_coat_pigmentation0.85399573
153MP0003828_pulmonary_edema0.84906835
154MP0000026_abnormal_inner_ear0.84663458
155MP0005085_abnormal_gallbladder_physiolo0.84583198
156MP0002116_abnormal_craniofacial_bone0.84231621
157MP0000955_abnormal_spinal_cord0.84038952
158MP0009703_decreased_birth_body0.83806409
159MP0005248_abnormal_Harderian_gland0.82169258
160MP0002081_perinatal_lethality0.81649671
161MP0005508_abnormal_skeleton_morphology0.81399142
162MP0000230_abnormal_systemic_arterial0.80569629
163MP0003252_abnormal_bile_duct0.80175978
164MP0005623_abnormal_meninges_morphology0.79857652
165* MP0003861_abnormal_nervous_system0.78916487
166MP0005423_abnormal_somatic_nervous0.77769510
167MP0000703_abnormal_thymus_morphology0.77552012
168MP0003137_abnormal_impulse_conducting0.77239266
169MP0005377_hearing/vestibular/ear_phenot0.76966726
170MP0001286_abnormal_eye_development0.76953923
171MP0003385_abnormal_body_wall0.73861350
172MP0000537_abnormal_urethra_morphology0.73639224
173MP0002249_abnormal_larynx_morphology0.72567149
174MP0009333_abnormal_splenocyte_physiolog0.72559361
175MP0000372_irregular_coat_pigmentation0.70262450
176MP0009053_abnormal_anal_canal0.68048108
177MP0002111_abnormal_tail_morphology0.66405084
178MP0002019_abnormal_tumor_incidence0.66106050
179MP0004808_abnormal_hematopoietic_stem0.64115706
180MP0006082_CNS_inflammation0.62909982
181MP0005023_abnormal_wound_healing0.62359645
182MP0002970_abnormal_white_adipose0.62325784
183MP0000858_altered_metastatic_potential0.60763658
184MP0009250_abnormal_appendicular_skeleto0.59809617

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.90285661
2Hepatoblastoma (HP:0002884)5.12463349
3Pancreatic cysts (HP:0001737)4.54760529
4Pancreatic fibrosis (HP:0100732)4.43843097
5Hypochromic microcytic anemia (HP:0004840)4.42871156
6Ependymoma (HP:0002888)4.37623936
7True hermaphroditism (HP:0010459)4.28018351
8Rib fusion (HP:0000902)4.15191108
9Nephroblastoma (Wilms tumor) (HP:0002667)3.85975687
10Molar tooth sign on MRI (HP:0002419)3.68369453
11Abnormality of midbrain morphology (HP:0002418)3.68369453
12Hyperventilation (HP:0002883)3.66799285
13Embryonal renal neoplasm (HP:0011794)3.63558216
14Abnormality of the lower motor neuron (HP:0002366)3.53787167
15Nephronophthisis (HP:0000090)3.49011570
16Neoplasm of striated muscle (HP:0009728)3.43732493
17Multiple enchondromatosis (HP:0005701)3.41077866
18Congenital stationary night blindness (HP:0007642)3.39755493
19Rhabdomyosarcoma (HP:0002859)3.28715988
20Medial flaring of the eyebrow (HP:0010747)3.26371245
21Genetic anticipation (HP:0003743)3.24270139
22Abnormality of the astrocytes (HP:0100707)3.21276102
23Astrocytoma (HP:0009592)3.21276102
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15950404
25Abnormality of the renal medulla (HP:0100957)3.14580589
26Renal duplication (HP:0000075)3.04231514
27Progressive cerebellar ataxia (HP:0002073)3.03910939
28Abnormality of the renal cortex (HP:0011035)3.01784059
29Gaze-evoked nystagmus (HP:0000640)2.96996888
30Type II lissencephaly (HP:0007260)2.96796421
31Abnormal lung lobation (HP:0002101)2.93823410
32Attenuation of retinal blood vessels (HP:0007843)2.93605764
33Chronic hepatic failure (HP:0100626)2.93577776
34Chromsome breakage (HP:0040012)2.93306423
35Cystic liver disease (HP:0006706)2.92922164
36Bifid tongue (HP:0010297)2.77917001
37Fused cervical vertebrae (HP:0002949)2.77651386
38Abolished electroretinogram (ERG) (HP:0000550)2.74904285
39Febrile seizures (HP:0002373)2.73667358
40Medulloblastoma (HP:0002885)2.71684956
41Rectovaginal fistula (HP:0000143)2.70344371
42Rectal fistula (HP:0100590)2.70344371
43Gait imbalance (HP:0002141)2.69899197
44Preauricular skin tag (HP:0000384)2.66629139
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.65563076
46Meckel diverticulum (HP:0002245)2.63190430
47Congenital primary aphakia (HP:0007707)2.60591814
48Aplasia/hypoplasia of the humerus (HP:0006507)2.57433766
49Intestinal fistula (HP:0100819)2.56636360
50Abnormality of the phalanges of the hallux (HP:0010057)2.51840694
51Skin tags (HP:0010609)2.51712368
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.51692727
53Hypoplasia of the fovea (HP:0007750)2.51692727
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.51662744
55Short humerus (HP:0005792)2.51505290
56Trismus (HP:0000211)2.51030598
57Pendular nystagmus (HP:0012043)2.48428394
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.48237403
59Sclerocornea (HP:0000647)2.47089694
60Abnormality of the ileum (HP:0001549)2.46006568
61Genital tract atresia (HP:0001827)2.45274668
62Partial duplication of the phalanx of hand (HP:0009999)2.44581715
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.43848851
64Partial duplication of thumb phalanx (HP:0009944)2.43117060
65Supernumerary spleens (HP:0009799)2.41455569
66Renal cortical cysts (HP:0000803)2.41216533
67Focal motor seizures (HP:0011153)2.40850625
68Nephrogenic diabetes insipidus (HP:0009806)2.39665067
69Broad-based gait (HP:0002136)2.39197458
70Inability to walk (HP:0002540)2.39000082
71Increased corneal curvature (HP:0100692)2.37818047
72Keratoconus (HP:0000563)2.37818047
73Tubulointerstitial nephritis (HP:0001970)2.37182098
74Amyotrophic lateral sclerosis (HP:0007354)2.36145650
75Glioma (HP:0009733)2.35191648
76Abnormality of chromosome segregation (HP:0002916)2.33762083
77Lissencephaly (HP:0001339)2.33585442
78Vaginal atresia (HP:0000148)2.33533071
79Protruding tongue (HP:0010808)2.32750585
80Ankyloglossia (HP:0010296)2.31071635
81Generalized hypotonia (HP:0001290)2.29777557
82Congenital hepatic fibrosis (HP:0002612)2.29731171
83Neoplasm of the heart (HP:0100544)2.29728655
84Abnormal rod and cone electroretinograms (HP:0008323)2.29292391
85Abnormality of the salivary glands (HP:0010286)2.28185673
86Atresia of the external auditory canal (HP:0000413)2.28144215
87Shawl scrotum (HP:0000049)2.27433487
88Anencephaly (HP:0002323)2.26951836
89Abnormal biliary tract physiology (HP:0012439)2.25904988
90Bile duct proliferation (HP:0001408)2.25904988
91Postaxial foot polydactyly (HP:0001830)2.25445658
92Focal seizures (HP:0007359)2.25226046
93Tongue fasciculations (HP:0001308)2.24704128
94Malignant neoplasm of the central nervous system (HP:0100836)2.23728920
95Colon cancer (HP:0003003)2.22207677
96Furrowed tongue (HP:0000221)2.20219111
97Impulsivity (HP:0100710)2.20184503
98Aplasia/Hypoplasia of the sternum (HP:0006714)2.19749980
99Drooling (HP:0002307)2.19663396
100Optic nerve hypoplasia (HP:0000609)2.18812504
101Tubular atrophy (HP:0000092)2.18186790
102Supernumerary ribs (HP:0005815)2.17720514
103Ragged-red muscle fibers (HP:0003200)2.17511883
104Abnormality of oral frenula (HP:0000190)2.16855118
105Decreased central vision (HP:0007663)2.15802761
106Small intestinal stenosis (HP:0012848)2.15175963
107Duodenal stenosis (HP:0100867)2.15175963
108Congenital sensorineural hearing impairment (HP:0008527)2.14975756
109Dialeptic seizures (HP:0011146)2.14116613
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13672596
111Abnormality of alanine metabolism (HP:0010916)2.13672596
112Hyperalaninemia (HP:0003348)2.13672596
113Progressive inability to walk (HP:0002505)2.13628030
114Supernumerary nipples (HP:0002558)2.13533983
115Intestinal atresia (HP:0011100)2.13382175
116Male pseudohermaphroditism (HP:0000037)2.10825005
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10292190
118Short 4th metacarpal (HP:0010044)2.09965486
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09965486
120Neoplasm of the oral cavity (HP:0100649)2.09289968
121Vaginal fistula (HP:0004320)2.09077884
122Diastasis recti (HP:0001540)2.08554764
123Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08364628
124Volvulus (HP:0002580)2.07656946
125Horizontal nystagmus (HP:0000666)2.07130864
126Hemiparesis (HP:0001269)2.06743236
127Cerebellar dysplasia (HP:0007033)2.06125221
128Polydipsia (HP:0001959)2.05474338
129Abnormal drinking behavior (HP:0030082)2.05474338
130Preauricular pit (HP:0004467)2.05353897
131Periauricular skin pits (HP:0100277)2.05353897
132Muscle fibrillation (HP:0010546)2.04850804
133Bony spicule pigmentary retinopathy (HP:0007737)2.04003573
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02774020
135Missing ribs (HP:0000921)2.01027009
136Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00391031
137Stomach cancer (HP:0012126)1.99796088
138Sensory axonal neuropathy (HP:0003390)1.99394086
139Neuroblastic tumors (HP:0004376)1.99185113
140Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.99185113
141Neuroblastoma (HP:0003006)1.99185113
142Primitive neuroectodermal tumor (HP:0030065)1.99185113
143Hypopigmentation of the fundus (HP:0007894)1.98322070
144Broad palm (HP:0001169)1.97790697
145Postaxial hand polydactyly (HP:0001162)1.96314057
146Supernumerary bones of the axial skeleton (HP:0009144)1.96080446
147Short middle phalanx of the 5th finger (HP:0004220)1.95573156
148Excessive salivation (HP:0003781)1.94842426
149Vertebral fusion (HP:0002948)1.94601958
150Glossoptosis (HP:0000162)1.94009275
151Abnormality of the labia minora (HP:0012880)1.93551162
152Anomalous pulmonary venous return (HP:0010772)1.93153493
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.93008672
154Large for gestational age (HP:0001520)1.92597113
155Methylmalonic acidemia (HP:0002912)1.92220091
156Poor coordination (HP:0002370)1.91791341
157Fair hair (HP:0002286)1.91262619
158Prominent occiput (HP:0000269)1.91223859
159Thyroid-stimulating hormone excess (HP:0002925)1.90691667
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89800544
161Testicular atrophy (HP:0000029)1.89653070
162Mesomelia (HP:0003027)1.88262345
163Occipital encephalocele (HP:0002085)1.87909550
164Hypothermia (HP:0002045)1.87611679
165Widely spaced teeth (HP:0000687)1.86900689
166Neuroectodermal neoplasm (HP:0030061)1.86455122
167Neuroepithelial neoplasm (HP:0030063)1.86455122
168Nervous tissue neoplasm (HP:0030060)1.86455122
169Increased nuchal translucency (HP:0010880)1.86251805
170Combined immunodeficiency (HP:0005387)1.85384702
171Asplenia (HP:0001746)1.85251249
172Pachygyria (HP:0001302)1.84038008
173Abnormal number of incisors (HP:0011064)1.84037650
174Retinal dysplasia (HP:0007973)1.83434012
175Abnormality of the radial head (HP:0003995)1.83410525
176Narrow forehead (HP:0000341)1.83293240
177Polyphagia (HP:0002591)1.83275917
178Dislocated radial head (HP:0003083)1.83261601
179Astigmatism (HP:0000483)1.82896299
180Preaxial hand polydactyly (HP:0001177)1.82869451
181Methylmalonic aciduria (HP:0012120)1.82818867
182Adenoma sebaceum (HP:0009720)1.82504034
183Angiofibromas (HP:0010615)1.82504034
184Chorioretinal atrophy (HP:0000533)1.82451964
185Embryonal neoplasm (HP:0002898)1.82421183
186Large earlobe (HP:0009748)1.82260391
187Short tibia (HP:0005736)1.81651425
188Broad thumb (HP:0011304)1.80384719
189Abnormality of macular pigmentation (HP:0008002)1.78662955
190Absent/shortened dynein arms (HP:0200106)1.78209066
191Dynein arm defect of respiratory motile cilia (HP:0012255)1.78209066
192Tubulointerstitial abnormality (HP:0001969)1.76233429
193Abnormal respiratory epithelium morphology (HP:0012253)1.72778919
194Abnormal respiratory motile cilium morphology (HP:0005938)1.72778919
195Constricted visual fields (HP:0001133)1.72595233
196Abnormal ciliary motility (HP:0012262)1.72562040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.68980197
2FRK6.70182417
3GRK54.46050626
4GRK64.40164961
5WNK32.95579338
6ADRBK22.94393989
7ERN12.85398960
8STK102.83603050
9CASK2.78072719
10TTK2.60011105
11BMPR1B2.56341034
12TYRO32.49948790
13MAP4K22.31178023
14MAP3K42.24314922
15MAPK132.19925468
16GRK12.16803867
17TGFBR22.12078704
18CSF1R2.09212050
19TRIM282.02183595
20PINK11.99941837
21MAPK71.98528931
22CDC71.96963002
23MATK1.94329041
24NUAK11.93775711
25INSRR1.86549444
26CDK71.82499716
27MARK11.82045818
28TNIK1.75000587
29WEE11.74864964
30DYRK31.73697438
31ZAK1.71539870
32WNK41.57231385
33MAP3K101.54406741
34NTRK11.51433842
35MKNK21.50674033
36GRK71.50402926
37OXSR11.49151546
38FGFR31.43582178
39PLK11.42461065
40CHEK21.42336010
41CAMK41.40492456
42MOS1.38378483
43BCR1.37283125
44PAK41.36626788
45WNK11.34229837
46MAP2K71.34185573
47PLK21.32008220
48LATS21.31982758
49EPHA41.30210331
50STK391.29665038
51STK38L1.28798749
52NEK21.27528733
53TAOK31.24062404
54CSNK1G21.19631489
55PAK31.18748245
56ADRBK11.11925620
57CSNK1G11.10340057
58PRKG21.10235914
59AKT31.08612563
60PRKCE1.05201444
61BUB11.04558361
62DAPK21.03725705
63HIPK21.03621157
64ERBB31.03227994
65CHEK11.02968574
66CSNK1G31.01484675
67SRPK11.01349504
68PNCK1.00582442
69CSNK1A1L0.98811198
70ALK0.98655853
71PRKCG0.97356982
72MAP2K40.93505049
73CAMKK20.93199107
74MAP2K60.93033913
75CCNB10.90127451
76MARK20.89812967
77EPHA20.86871892
78PLK40.84520353
79NEK10.82720121
80TLK10.82671533
81ITK0.81644375
82SCYL20.79204299
83RPS6KA40.76150907
84FGFR20.74154667
85PTK2B0.71881234
86CDK20.67976654
87TIE10.67758399
88ATM0.67605962
89MAP3K80.67094760
90TGFBR10.67068650
91RPS6KB20.65639560
92CAMK2A0.65562867
93AURKB0.65143235
94AURKA0.63558436
95EPHA30.63467999
96TXK0.62055050
97PKN10.60701376
98PIK3CA0.60033150
99NTRK30.59390515
100PASK0.59048269
101BRSK10.58624395
102STK30.58488435
103PDGFRA0.57949277
104TSSK60.57294745
105BCKDK0.56831574
106CDK40.56707554
107PHKG10.55543420
108PHKG20.55543420
109EIF2AK30.54200271
110ATR0.53327936
111OBSCN0.53178615
112CAMK10.52849251
113IRAK10.52787098
114FER0.52027423
115EIF2AK10.51291659
116CDK190.50751133
117DYRK1B0.50130508
118TAF10.50063018
119VRK10.49731471
120AKT20.49145831
121CSNK1A10.48768955
122MAP3K90.48680806
123STK160.48636498
124CDK10.47668954
125PRKACA0.47582452
126MTOR0.47426293
127EIF2AK20.47391297
128ACVR1B0.47354258
129TEC0.46061798
130CSNK1D0.45719801
131MELK0.45676070
132PLK30.45297220
133PIK3CG0.45149873
134DYRK1A0.44743249
135SGK20.43238153
136ERBB20.41281788
137TNK20.41246413
138MAP3K70.40773575
139CDK180.40308703
140MAPKAPK50.40003095
141STK110.38061981
142CDK150.37745874
143PRKG10.36707903
144CDK140.34863750
145NME10.34306116
146MUSK0.34150884
147RPS6KA50.34078974
148CDK11A0.34058457
149BRSK20.33886289
150MKNK10.33821747
151PAK10.33787150
152CDK30.33733525
153CSK0.33140559
154PRKACB0.32566586
155PRKCI0.32507459
156CSNK1E0.32017056
157IGF1R0.31610217
158PRKCA0.31120025
159MAPK100.30811698
160PTK20.30021573
161BRD40.29933824
162MINK10.29401795
163GSK3B0.27673847
164MAPK140.27014925
165NTRK20.26301205
166PRKD30.25593304
167MST40.25176125
168KSR10.23962110
169KDR0.23034192
170MAPK10.21583332
171LRRK20.21143335
172CHUK0.20485412
173FLT30.20196129
174DYRK20.19140373

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.38277286
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.36062161
3Phototransduction_Homo sapiens_hsa047443.08196215
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02951321
5Mismatch repair_Homo sapiens_hsa034303.00333338
6Nicotine addiction_Homo sapiens_hsa050332.92346940
7Butanoate metabolism_Homo sapiens_hsa006502.51612673
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49414725
9Cell cycle_Homo sapiens_hsa041102.46709330
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32204776
11RNA transport_Homo sapiens_hsa030132.30466819
12Nitrogen metabolism_Homo sapiens_hsa009102.16308378
13Vitamin B6 metabolism_Homo sapiens_hsa007502.10940482
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04785836
15Spliceosome_Homo sapiens_hsa030402.01785936
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00664331
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99322856
18mRNA surveillance pathway_Homo sapiens_hsa030151.93506215
19Thyroid cancer_Homo sapiens_hsa052161.89945103
20Homologous recombination_Homo sapiens_hsa034401.88019645
21Tryptophan metabolism_Homo sapiens_hsa003801.85290288
22Fanconi anemia pathway_Homo sapiens_hsa034601.83860955
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77124157
24Morphine addiction_Homo sapiens_hsa050321.76794282
25Ether lipid metabolism_Homo sapiens_hsa005651.76148564
26Taste transduction_Homo sapiens_hsa047421.75800670
27Propanoate metabolism_Homo sapiens_hsa006401.74884258
28Base excision repair_Homo sapiens_hsa034101.74608755
29Selenocompound metabolism_Homo sapiens_hsa004501.73620034
30Ribosome_Homo sapiens_hsa030101.67329913
31RNA degradation_Homo sapiens_hsa030181.59596993
32Protein export_Homo sapiens_hsa030601.57908272
33GABAergic synapse_Homo sapiens_hsa047271.55869920
34Nucleotide excision repair_Homo sapiens_hsa034201.52233020
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52080077
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52003935
37Basal cell carcinoma_Homo sapiens_hsa052171.51395181
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.50744447
39Oxidative phosphorylation_Homo sapiens_hsa001901.50115516
40Olfactory transduction_Homo sapiens_hsa047401.47643985
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44718805
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.42779157
43Glutamatergic synapse_Homo sapiens_hsa047241.41252107
44Circadian entrainment_Homo sapiens_hsa047131.38647812
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37946025
46Fructose and mannose metabolism_Homo sapiens_hsa000511.37855364
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35609694
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.24310963
49p53 signaling pathway_Homo sapiens_hsa041151.23419567
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22768873
51MicroRNAs in cancer_Homo sapiens_hsa052061.22256762
52Colorectal cancer_Homo sapiens_hsa052101.21863730
53Insulin secretion_Homo sapiens_hsa049111.20441940
54Serotonergic synapse_Homo sapiens_hsa047261.19367892
55Non-homologous end-joining_Homo sapiens_hsa034501.19345523
56ABC transporters_Homo sapiens_hsa020101.19178241
57Hippo signaling pathway_Homo sapiens_hsa043901.16234545
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16049191
59Parkinsons disease_Homo sapiens_hsa050121.15776741
60Caffeine metabolism_Homo sapiens_hsa002321.15296135
61Chemical carcinogenesis_Homo sapiens_hsa052041.11916582
62Oocyte meiosis_Homo sapiens_hsa041141.11622826
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11568680
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10388377
65Hedgehog signaling pathway_Homo sapiens_hsa043401.07946382
66Primary immunodeficiency_Homo sapiens_hsa053401.06229551
67mTOR signaling pathway_Homo sapiens_hsa041501.06036372
68One carbon pool by folate_Homo sapiens_hsa006701.05079931
69Peroxisome_Homo sapiens_hsa041461.03053130
70Retinol metabolism_Homo sapiens_hsa008301.02634471
71Pathways in cancer_Homo sapiens_hsa052001.02167232
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01593759
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01574172
74Galactose metabolism_Homo sapiens_hsa000521.01007610
75Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00287928
76T cell receptor signaling pathway_Homo sapiens_hsa046600.99009692
77HTLV-I infection_Homo sapiens_hsa051660.98995881
78Wnt signaling pathway_Homo sapiens_hsa043100.98072453
79Arachidonic acid metabolism_Homo sapiens_hsa005900.96999709
80Adherens junction_Homo sapiens_hsa045200.96432330
81Rap1 signaling pathway_Homo sapiens_hsa040150.96305025
82beta-Alanine metabolism_Homo sapiens_hsa004100.95649069
83Salivary secretion_Homo sapiens_hsa049700.95535417
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91942453
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.90988387
86Calcium signaling pathway_Homo sapiens_hsa040200.89956476
87Linoleic acid metabolism_Homo sapiens_hsa005910.89004528
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87568923
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86760472
90Viral carcinogenesis_Homo sapiens_hsa052030.86306297
91Regulation of autophagy_Homo sapiens_hsa041400.85866539
92Huntingtons disease_Homo sapiens_hsa050160.85828116
93Cardiac muscle contraction_Homo sapiens_hsa042600.85087813
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84696174
95Basal transcription factors_Homo sapiens_hsa030220.84576029
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84393840
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.84384888
98Dopaminergic synapse_Homo sapiens_hsa047280.83516353
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83019991
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82023675
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78790121
102Antigen processing and presentation_Homo sapiens_hsa046120.78427678
103Non-small cell lung cancer_Homo sapiens_hsa052230.77811347
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77445258
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77290563
106Glycerolipid metabolism_Homo sapiens_hsa005610.77064147
107Ovarian steroidogenesis_Homo sapiens_hsa049130.76993210
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.76413343
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76276487
110Proteoglycans in cancer_Homo sapiens_hsa052050.75509357
111Endometrial cancer_Homo sapiens_hsa052130.75147647
112Herpes simplex infection_Homo sapiens_hsa051680.72540023
113VEGF signaling pathway_Homo sapiens_hsa043700.71840310
114Purine metabolism_Homo sapiens_hsa002300.70993098
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.70925551
116Inositol phosphate metabolism_Homo sapiens_hsa005620.70862028
117Pancreatic cancer_Homo sapiens_hsa052120.69837025
118Acute myeloid leukemia_Homo sapiens_hsa052210.69507895
119Long-term depression_Homo sapiens_hsa047300.69376529
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69114001
121Pyrimidine metabolism_Homo sapiens_hsa002400.68819979
122Alzheimers disease_Homo sapiens_hsa050100.68335989
123Circadian rhythm_Homo sapiens_hsa047100.67058557
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.66209519
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66145573
126RNA polymerase_Homo sapiens_hsa030200.65123908
127Choline metabolism in cancer_Homo sapiens_hsa052310.64089660
128Asthma_Homo sapiens_hsa053100.63814575
129TGF-beta signaling pathway_Homo sapiens_hsa043500.63126497
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63050208
131Fatty acid degradation_Homo sapiens_hsa000710.62435749
132Fat digestion and absorption_Homo sapiens_hsa049750.59859969
133Small cell lung cancer_Homo sapiens_hsa052220.59714537
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58947142
135Cholinergic synapse_Homo sapiens_hsa047250.58754683
136Melanogenesis_Homo sapiens_hsa049160.58698943
137Histidine metabolism_Homo sapiens_hsa003400.57985145
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57125695
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57064276
140Alcoholism_Homo sapiens_hsa050340.55273641
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54881327
142Metabolic pathways_Homo sapiens_hsa011000.54451981
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54265292
144Notch signaling pathway_Homo sapiens_hsa043300.53692399
145Ras signaling pathway_Homo sapiens_hsa040140.53609186
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53306970
147Renin secretion_Homo sapiens_hsa049240.51837790
148Amphetamine addiction_Homo sapiens_hsa050310.51792980
149Dorso-ventral axis formation_Homo sapiens_hsa043200.50666988
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50441901
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50025317
152Bladder cancer_Homo sapiens_hsa052190.49642713
153Oxytocin signaling pathway_Homo sapiens_hsa049210.49610734
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.49499584
155Tight junction_Homo sapiens_hsa045300.49350819
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48741295
157cAMP signaling pathway_Homo sapiens_hsa040240.48347202
158Axon guidance_Homo sapiens_hsa043600.47946049
159Steroid biosynthesis_Homo sapiens_hsa001000.47603463
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.47373497
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46847009
162Long-term potentiation_Homo sapiens_hsa047200.46349820
163Fatty acid metabolism_Homo sapiens_hsa012120.45954523
164Cocaine addiction_Homo sapiens_hsa050300.45664920
165Chronic myeloid leukemia_Homo sapiens_hsa052200.45081563
166NF-kappa B signaling pathway_Homo sapiens_hsa040640.43298073
167Collecting duct acid secretion_Homo sapiens_hsa049660.43249921
168Viral myocarditis_Homo sapiens_hsa054160.42684694
169Focal adhesion_Homo sapiens_hsa045100.42423662
170Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42375841
171Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42137728
172Apoptosis_Homo sapiens_hsa042100.41695023
173GnRH signaling pathway_Homo sapiens_hsa049120.41154190
174Melanoma_Homo sapiens_hsa052180.41002804
175Epstein-Barr virus infection_Homo sapiens_hsa051690.40893453
176Lysine degradation_Homo sapiens_hsa003100.40433762
177Prostate cancer_Homo sapiens_hsa052150.39200095
178Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38363091
179Cysteine and methionine metabolism_Homo sapiens_hsa002700.36708416
180Gastric acid secretion_Homo sapiens_hsa049710.36464101
181Type I diabetes mellitus_Homo sapiens_hsa049400.34483031
182Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33186430
183Sulfur metabolism_Homo sapiens_hsa009200.32932119
184Glycerophospholipid metabolism_Homo sapiens_hsa005640.31803428

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