ZDHHC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.41304072
2protein maturation by protein folding (GO:0022417)5.23382147
3DNA strand elongation involved in DNA replication (GO:0006271)5.15721710
4formation of translation preinitiation complex (GO:0001731)4.94222922
5IMP biosynthetic process (GO:0006188)4.88133139
6DNA strand elongation (GO:0022616)4.80835758
7telomere maintenance via semi-conservative replication (GO:0032201)4.62481849
8folic acid-containing compound biosynthetic process (GO:0009396)4.60332660
9nucleobase biosynthetic process (GO:0046112)4.58952521
10DNA replication initiation (GO:0006270)4.58717307
11protein retention in ER lumen (GO:0006621)4.45384799
12IMP metabolic process (GO:0046040)4.36458623
13purine nucleobase biosynthetic process (GO:0009113)4.14831640
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.14378522
15protein localization to kinetochore (GO:0034501)4.05175686
16histone arginine methylation (GO:0034969)4.04683326
17telomere maintenance via recombination (GO:0000722)4.03042092
18GDP-mannose metabolic process (GO:0019673)4.00522105
19nuclear pore organization (GO:0006999)3.95613028
20proline biosynthetic process (GO:0006561)3.95177289
21mitotic nuclear envelope disassembly (GO:0007077)3.94975248
22mitotic recombination (GO:0006312)3.87337558
23ribosome assembly (GO:0042255)3.87284764
24nuclear pore complex assembly (GO:0051292)3.84926049
25establishment of viral latency (GO:0019043)3.79890606
26peptidyl-arginine methylation (GO:0018216)3.75910480
27peptidyl-arginine N-methylation (GO:0035246)3.75910480
28DNA deamination (GO:0045006)3.75216820
29ribosomal small subunit assembly (GO:0000028)3.73736733
30ribosome biogenesis (GO:0042254)3.68474898
31membrane disassembly (GO:0030397)3.64053786
32nuclear envelope disassembly (GO:0051081)3.64053786
33maturation of SSU-rRNA (GO:0030490)3.63245895
34telomere maintenance via telomere lengthening (GO:0010833)3.63212959
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.63205672
36nuclear envelope reassembly (GO:0031468)3.59564275
37mitotic nuclear envelope reassembly (GO:0007084)3.59564275
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59080252
39proteasome assembly (GO:0043248)3.58638542
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55648955
41DNA replication checkpoint (GO:0000076)3.55229295
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.51749953
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50945998
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36950928
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36507280
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32789470
47tRNA aminoacylation for protein translation (GO:0006418)3.29112473
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27834855
49DNA replication-dependent nucleosome assembly (GO:0006335)3.27447320
50DNA replication-dependent nucleosome organization (GO:0034723)3.27447320
51cell cycle G1/S phase transition (GO:0044843)3.26631984
52G1/S transition of mitotic cell cycle (GO:0000082)3.26631984
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24312074
54negative regulation of ligase activity (GO:0051352)3.24312074
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23119462
56amino acid activation (GO:0043038)3.20438918
57tRNA aminoacylation (GO:0043039)3.20438918
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19831954
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19831954
60protein localization to chromosome, centromeric region (GO:0071459)3.19664361
61establishment of integrated proviral latency (GO:0075713)3.16743084
62ribonucleoprotein complex biogenesis (GO:0022613)3.16304162
63regulation of translational fidelity (GO:0006450)3.15946985
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15721097
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13046799
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13046799
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13046799
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12410700
69transcription-coupled nucleotide-excision repair (GO:0006283)3.11850345
70COPI coating of Golgi vesicle (GO:0048205)3.11573398
71Golgi transport vesicle coating (GO:0048200)3.11573398
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09398058
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.09398058
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07633981
75regulation of protein heterodimerization activity (GO:0043497)3.05910706
76peptidyl-arginine omega-N-methylation (GO:0035247)3.05434676
77regulation of mitochondrial translation (GO:0070129)3.05021508
78mitotic chromosome condensation (GO:0007076)3.04969043
79translational initiation (GO:0006413)3.04502445
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.04398352
81cullin deneddylation (GO:0010388)3.04305869
82protein deneddylation (GO:0000338)3.01762554
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.00994231
84nucleobase-containing small molecule interconversion (GO:0015949)2.98073687
85translational elongation (GO:0006414)2.97118552
86postreplication repair (GO:0006301)2.96920477
87DNA duplex unwinding (GO:0032508)2.96578819
88mitotic metaphase plate congression (GO:0007080)2.96021822
89CENP-A containing nucleosome assembly (GO:0034080)2.95834366
90negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.95814119
91ribosomal large subunit biogenesis (GO:0042273)2.95675537
92DNA geometric change (GO:0032392)2.94731023
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94402133
94pore complex assembly (GO:0046931)2.93930354
95spliceosomal snRNP assembly (GO:0000387)2.93609595
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93309156
97heterochromatin organization (GO:0070828)2.91128598
98nucleotide-sugar biosynthetic process (GO:0009226)2.89943051
99translational termination (GO:0006415)2.89179231
100deoxyribonucleotide biosynthetic process (GO:0009263)2.88732590
101viral transcription (GO:0019083)2.88670354
102ribosomal small subunit biogenesis (GO:0042274)2.88002263
103viral mRNA export from host cell nucleus (GO:0046784)2.87180858
104base-excision repair (GO:0006284)2.86871164
105attachment of spindle microtubules to kinetochore (GO:0008608)2.85513940
106mitotic sister chromatid segregation (GO:0000070)2.84525820
107chromatin remodeling at centromere (GO:0031055)2.84458744
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84250993
109de novo protein folding (GO:0006458)2.83971527
110negative regulation of RNA splicing (GO:0033119)2.83623807
111pinocytosis (GO:0006907)2.83283564
112rRNA processing (GO:0006364)2.83279938
113pentose-phosphate shunt (GO:0006098)2.82131633
114nuclear envelope organization (GO:0006998)2.81292398
115DNA replication-independent nucleosome assembly (GO:0006336)2.80878230
116DNA replication-independent nucleosome organization (GO:0034724)2.80878230
117pteridine-containing compound biosynthetic process (GO:0042559)2.80321893
118positive regulation of cell cycle arrest (GO:0071158)2.80275686
119positive regulation of ligase activity (GO:0051351)2.80119616
120pentose metabolic process (GO:0019321)2.79913465
121regulation of translational termination (GO:0006449)2.78507162
122pseudouridine synthesis (GO:0001522)2.76376793
123guanosine-containing compound biosynthetic process (GO:1901070)2.76306974
124pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.76227735
125chaperone-mediated protein transport (GO:0072321)2.75807872
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.75534133
127tetrahydrofolate metabolic process (GO:0046653)2.75299058
128regulation of cellular amino acid metabolic process (GO:0006521)2.74815583
129de novo posttranslational protein folding (GO:0051084)2.74595101
130CTP metabolic process (GO:0046036)2.72580230
131CTP biosynthetic process (GO:0006241)2.72580230
132folic acid metabolic process (GO:0046655)2.72232680
133UV protection (GO:0009650)2.70414290
134NADPH regeneration (GO:0006740)2.67627541
135L-serine metabolic process (GO:0006563)2.67301417
136mitochondrial fusion (GO:0008053)2.64986283
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64908186
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64727550
139positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.59024074
140protein complex localization (GO:0031503)2.58336366
1412-deoxyribonucleotide biosynthetic process (GO:0009265)2.58190005
142deoxyribose phosphate biosynthetic process (GO:0046385)2.58190005
143positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.57971416
144UTP biosynthetic process (GO:0006228)2.53845526
145proline metabolic process (GO:0006560)2.51142818
146regulation of mitotic spindle organization (GO:0060236)2.49379201
147iron-sulfur cluster assembly (GO:0016226)2.45886494
148metallo-sulfur cluster assembly (GO:0031163)2.45886494
149glucose catabolic process (GO:0006007)2.44035810
150protein targeting to mitochondrion (GO:0006626)2.41309861
151rRNA transcription (GO:0009303)2.40828105
152skin morphogenesis (GO:0043589)2.38383530
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.35321495
154hemidesmosome assembly (GO:0031581)2.35118543
155regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.35087117
156sister chromatid segregation (GO:0000819)2.32618773
157UTP metabolic process (GO:0046051)2.32077172
158planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30773339
159regulation of ubiquitin-protein transferase activity (GO:0051438)2.29394874
160lipopolysaccharide biosynthetic process (GO:0009103)2.28802933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70373095
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.24867145
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.05368696
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.23766007
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93705898
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88935572
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81807906
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.73935417
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73763318
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72646937
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.68637324
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.66926987
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63212938
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56637883
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54951879
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46641154
17XRN2_22483619_ChIP-Seq_HELA_Human2.39942795
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35981000
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.31962334
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31741593
21DCP1A_22483619_ChIP-Seq_HELA_Human2.27789537
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.20796614
23AR_21909140_ChIP-Seq_LNCAP_Human2.02192900
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01575929
25MYC_22102868_ChIP-Seq_BL_Human1.98972021
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98585008
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96915039
28VDR_23849224_ChIP-Seq_CD4+_Human1.94706504
29GABP_19822575_ChIP-Seq_HepG2_Human1.93009123
30ZNF263_19887448_ChIP-Seq_K562_Human1.90414515
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86450446
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81720083
33FOXP3_21729870_ChIP-Seq_TREG_Human1.81253151
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79214243
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77696067
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.75091755
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74432738
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74106571
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71127022
40CIITA_25753668_ChIP-Seq_RAJI_Human1.70942726
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68525567
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66825578
43TTF2_22483619_ChIP-Seq_HELA_Human1.66031672
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65776269
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61096478
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60229361
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58786418
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51362089
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49519500
50KDM5A_27292631_Chip-Seq_BREAST_Human1.45878497
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.44814241
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44431133
53RACK7_27058665_Chip-Seq_MCF-7_Human1.43906235
54VDR_21846776_ChIP-Seq_THP-1_Human1.42380454
55LXR_22292898_ChIP-Seq_THP-1_Human1.41437478
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.41247627
57ELK1_19687146_ChIP-ChIP_HELA_Human1.40454386
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40198966
59TFEB_21752829_ChIP-Seq_HELA_Human1.38906802
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37663602
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36499666
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35327128
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.35275082
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34480195
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34236839
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33881566
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32841003
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31827730
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31148706
70* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25917544
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25141149
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25003535
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24882471
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21198837
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20317520
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19649228
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18275726
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17128409
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16650187
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14845481
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14438426
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14101845
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12709506
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12217511
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11931954
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11353444
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09932860
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09598795
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09029878
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.08227463
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06846724
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06584979
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05155162
94P68_20966046_ChIP-Seq_HELA_Human1.04822912
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03968659
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03819589
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03557416
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.03323350
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03090792
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02811596
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99435102
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99417552
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99020870
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96320830
105SPI1_23547873_ChIP-Seq_NB4_Human0.93744784
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92962134
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92862818
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.92790569
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91867387
110ATF3_27146783_Chip-Seq_COLON_Human0.91314253
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90972398
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90114965
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89284741
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88755769
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88043071
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87016071
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.83441905
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83354307
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80090365
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79107450
121CHD1_26751641_Chip-Seq_LNCaP_Human0.78261533
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76898730
123* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76366178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.49966135
2MP0004957_abnormal_blastocyst_morpholog3.86841720
3MP0003077_abnormal_cell_cycle3.64903505
4MP0003111_abnormal_nucleus_morphology3.62106906
5MP0002877_abnormal_melanocyte_morpholog3.42796917
6MP0010094_abnormal_chromosome_stability3.32513890
7MP0010352_gastrointestinal_tract_polyps3.11370896
8MP0006054_spinal_hemorrhage2.61310258
9MP0008932_abnormal_embryonic_tissue2.57339276
10MP0008260_abnormal_autophagy2.54466360
11MP0005257_abnormal_intraocular_pressure2.52347894
12MP0008007_abnormal_cellular_replicative2.51658383
13MP0001730_embryonic_growth_arrest2.45240969
14MP0008058_abnormal_DNA_repair2.42503390
15MP0005451_abnormal_body_composition2.37142148
16MP0009840_abnormal_foam_cell2.33987319
17MP0003705_abnormal_hypodermis_morpholog2.31451388
18MP0002396_abnormal_hematopoietic_system2.29260749
19MP0004272_abnormal_basement_membrane2.26052686
20MP0005058_abnormal_lysosome_morphology2.23514718
21MP0010030_abnormal_orbit_morphology2.19971262
22MP0008057_abnormal_DNA_replication2.15608236
23MP0000350_abnormal_cell_proliferation2.12672596
24MP0003123_paternal_imprinting2.12544234
25MP0003941_abnormal_skin_development2.07381035
26MP0010368_abnormal_lymphatic_system1.92371568
27MP0005397_hematopoietic_system_phenotyp1.82288839
28MP0001545_abnormal_hematopoietic_system1.82288839
29MP0008438_abnormal_cutaneous_collagen1.79713508
30MP0004808_abnormal_hematopoietic_stem1.74702988
31MP0001697_abnormal_embryo_size1.73174183
32MP0002080_prenatal_lethality1.69006191
33MP0000358_abnormal_cell_content/1.62403747
34MP0010307_abnormal_tumor_latency1.60227069
35MP0002796_impaired_skin_barrier1.56330567
36MP0001672_abnormal_embryogenesis/_devel1.55769503
37MP0005380_embryogenesis_phenotype1.55769503
38MP0003984_embryonic_growth_retardation1.54172553
39MP0004197_abnormal_fetal_growth/weight/1.51859572
40MP0004233_abnormal_muscle_weight1.51851206
41MP0002088_abnormal_embryonic_growth/wei1.47432248
42MP0005023_abnormal_wound_healing1.46520743
43MP0000858_altered_metastatic_potential1.46348768
44MP0003806_abnormal_nucleotide_metabolis1.46001026
45MP0000490_abnormal_crypts_of1.44756954
46MP0004185_abnormal_adipocyte_glucose1.44573052
47MP0002085_abnormal_embryonic_tissue1.43781920
48MP0002019_abnormal_tumor_incidence1.43353135
49MP0003786_premature_aging1.42522149
50MP0009333_abnormal_splenocyte_physiolog1.40448604
51MP0000751_myopathy1.39101650
52MP0003566_abnormal_cell_adhesion1.38496702
53MP0003191_abnormal_cellular_cholesterol1.38495649
54MP0002060_abnormal_skin_morphology1.37141532
55MP0000313_abnormal_cell_death1.36245194
56MP0002086_abnormal_extraembryonic_tissu1.33763890
57MP0002084_abnormal_developmental_patter1.33674174
58MP0001915_intracranial_hemorrhage1.28942522
59MP0009053_abnormal_anal_canal1.28631752
60MP0000537_abnormal_urethra_morphology1.27962099
61MP0003221_abnormal_cardiomyocyte_apopto1.26844787
62MP0009697_abnormal_copulation1.23474258
63MP0009278_abnormal_bone_marrow1.23178718
64MP0003115_abnormal_respiratory_system1.22740055
65MP0000003_abnormal_adipose_tissue1.22182615
66MP0004858_abnormal_nervous_system1.20836432
67MP0001299_abnormal_eye_distance/1.20626298
68MP0000762_abnormal_tongue_morphology1.18264768
69MP0005220_abnormal_exocrine_pancreas1.18132618
70MP0003453_abnormal_keratinocyte_physiol1.16520028
71MP0005076_abnormal_cell_differentiation1.16350657
72MP0003950_abnormal_plasma_membrane1.13319713
73MP0001661_extended_life_span1.12423058
74MP0000750_abnormal_muscle_regeneration1.12177764
75MP0003279_aneurysm1.12066596
76MP0003385_abnormal_body_wall1.10952501
77MP0000747_muscle_weakness1.07883803
78MP0005384_cellular_phenotype1.06712881
79MP0004133_heterotaxia1.05845217
80MP0009384_cardiac_valve_regurgitation1.05504733
81MP0001243_abnormal_dermal_layer1.03970182
82MP0003942_abnormal_urinary_system1.03863296
83MP0000733_abnormal_muscle_development1.03577289
84MP0001542_abnormal_bone_strength1.03220798
85MP0002234_abnormal_pharynx_morphology1.03170649
86MP0005394_taste/olfaction_phenotype1.02939389
87MP0005499_abnormal_olfactory_system1.02939389
88MP0003315_abnormal_perineum_morphology1.02598891
89MP0001216_abnormal_epidermal_layer1.01251992
90MP0003119_abnormal_digestive_system1.00532654
91MP0005623_abnormal_meninges_morphology0.99338759
92MP0005621_abnormal_cell_physiology0.98485512
93MP0003172_abnormal_lysosome_physiology0.97409613
94MP0005197_abnormal_uvea_morphology0.97060337
95MP0005330_cardiomyopathy0.97021880
96MP0005083_abnormal_biliary_tract0.96570969
97MP0001293_anophthalmia0.95952812
98MP0001346_abnormal_lacrimal_gland0.95761244
99MP0008789_abnormal_olfactory_epithelium0.95345130
100MP0000703_abnormal_thymus_morphology0.95088758
101MP0002398_abnormal_bone_marrow0.94487331
102MP0002722_abnormal_immune_system0.93839348
103MP0003718_maternal_effect0.93587974
104MP0003121_genomic_imprinting0.92842587
105MP0000759_abnormal_skeletal_muscle0.91647201
106MP0002092_abnormal_eye_morphology0.91542704
107MP0000689_abnormal_spleen_morphology0.87943591
108MP0000465_gastrointestinal_hemorrhage0.87336193
109MP0003567_abnormal_fetal_cardiomyocyte0.87034902
110MP0008877_abnormal_DNA_methylation0.86456868
111MP0005408_hypopigmentation0.84921270
112MP0001958_emphysema0.83670649
113MP0006035_abnormal_mitochondrial_morpho0.83062703
114MP0001727_abnormal_embryo_implantation0.82736385
115MP0001849_ear_inflammation0.81517320
116MP0002177_abnormal_outer_ear0.80001986
117MP0003091_abnormal_cell_migration0.79933067
118MP0010771_integument_phenotype0.78452818
119MP0003890_abnormal_embryonic-extraembry0.78238827
120MP0002282_abnormal_trachea_morphology0.78096689
121MP0002653_abnormal_ependyma_morphology0.77992729
122MP0002429_abnormal_blood_cell0.77841383
123MP0005501_abnormal_skin_physiology0.75872824
124MP0002089_abnormal_postnatal_growth/wei0.75422483
125MP0002111_abnormal_tail_morphology0.74971826
126MP0001881_abnormal_mammary_gland0.73157888
127MP0000627_abnormal_mammary_gland0.73142216
128MP0003943_abnormal_hepatobiliary_system0.72688778
129MP0000534_abnormal_ureter_morphology0.72056348
130MP0005193_abnormal_anterior_eye0.71215868
131MP0008770_decreased_survivor_rate0.70901913
132MP0009672_abnormal_birth_weight0.70185454
133MP0003763_abnormal_thymus_physiology0.67484109
134MP0001286_abnormal_eye_development0.65451582
135MP0000477_abnormal_intestine_morphology0.65103685
136MP0002697_abnormal_eye_size0.64663839
137MP0001853_heart_inflammation0.64360852
138MP0002751_abnormal_autonomic_nervous0.62949436
139MP0002269_muscular_atrophy0.61459786
140MP0003186_abnormal_redox_activity0.61428035
141MP0000428_abnormal_craniofacial_morphol0.59279003
142MP0000598_abnormal_liver_morphology0.58731224
143MP0005391_vision/eye_phenotype0.57932543

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)3.76537043
2Abnormality of the anterior horn cell (HP:0006802)3.76537043
3Abnormality of the calcaneus (HP:0008364)3.66779578
4Microvesicular hepatic steatosis (HP:0001414)3.50377152
511 pairs of ribs (HP:0000878)3.27062443
6Selective tooth agenesis (HP:0001592)3.16628786
7Microretrognathia (HP:0000308)3.15311487
8Oral leukoplakia (HP:0002745)3.10825072
9Aplastic anemia (HP:0001915)3.08611532
10Progressive muscle weakness (HP:0003323)3.08004701
11Short nail (HP:0001799)3.06701255
12Protrusio acetabuli (HP:0003179)3.01724199
13Testicular atrophy (HP:0000029)2.99269338
14Trismus (HP:0000211)2.98860285
15Cerebral hypomyelination (HP:0006808)2.90575961
16Atrophic scars (HP:0001075)2.80390089
17Birth length less than 3rd percentile (HP:0003561)2.74893291
18Carpal bone hypoplasia (HP:0001498)2.73804865
19Glossoptosis (HP:0000162)2.71576079
20Abnormality of the distal phalanges of the toes (HP:0010182)2.71062194
21Patellar aplasia (HP:0006443)2.68310345
22Rough bone trabeculation (HP:0100670)2.63448236
23Ragged-red muscle fibers (HP:0003200)2.59705655
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59491250
25Vertebral compression fractures (HP:0002953)2.58003838
26Achilles tendon contracture (HP:0001771)2.55017791
27Thrombocytosis (HP:0001894)2.54748045
28Broad distal phalanx of finger (HP:0009836)2.54181481
29Cervical subluxation (HP:0003308)2.52464495
30Entropion (HP:0000621)2.52145522
31Severe visual impairment (HP:0001141)2.51897471
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50113316
33Short 4th metacarpal (HP:0010044)2.50113316
34Increased density of long bones (HP:0006392)2.48623517
35Ulnar bowing (HP:0003031)2.47645136
36Calcaneovalgus deformity (HP:0001848)2.46033756
37Poikiloderma (HP:0001029)2.44075479
38Aplasia/Hypoplasia of the patella (HP:0006498)2.44059677
39Multiple enchondromatosis (HP:0005701)2.43919896
40Type I transferrin isoform profile (HP:0003642)2.43402219
41Elbow flexion contracture (HP:0002987)2.41698952
42Cutaneous melanoma (HP:0012056)2.37044998
43Abnormal protein glycosylation (HP:0012346)2.35924615
44Abnormal glycosylation (HP:0012345)2.35924615
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35924615
46Abnormal protein N-linked glycosylation (HP:0012347)2.35924615
47Neoplasm of the pancreas (HP:0002894)2.35262360
48Reticulocytopenia (HP:0001896)2.34221231
49Abnormality of cells of the erythroid lineage (HP:0012130)2.33699690
50Reduced antithrombin III activity (HP:0001976)2.33582304
51Abnormal number of erythroid precursors (HP:0012131)2.33223099
52Long palpebral fissure (HP:0000637)2.32263516
53Distal lower limb amyotrophy (HP:0008944)2.32186465
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.31482096
55Hand muscle atrophy (HP:0009130)2.30865039
56Abnormality of the Achilles tendon (HP:0005109)2.29799271
57Colon cancer (HP:0003003)2.28694123
58Generalized amyotrophy (HP:0003700)2.27497067
59Irregular epiphyses (HP:0010582)2.25964942
60Breast hypoplasia (HP:0003187)2.25612187
61Abnormality of the umbilical cord (HP:0010881)2.24575223
62Hyperacusis (HP:0010780)2.22278354
63Metaphyseal cupping (HP:0003021)2.18831296
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17507993
65Biconcave vertebral bodies (HP:0004586)2.16872197
66Spinal rigidity (HP:0003306)2.16026696
67Abnormal gallbladder physiology (HP:0012438)2.14846077
68Cholecystitis (HP:0001082)2.14846077
69Deformed tarsal bones (HP:0008119)2.13455666
70Optic nerve coloboma (HP:0000588)2.12305976
71Fragile skin (HP:0001030)2.11262044
72Vertebral hypoplasia (HP:0008417)2.10746175
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10746175
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.10538950
75Osteolytic defects of the hand bones (HP:0009699)2.10538950
76Missing ribs (HP:0000921)2.08847690
77Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08481718
78Absent epiphyses (HP:0010577)2.08481718
79Abnormality of the fetal cardiovascular system (HP:0010948)2.07064460
80Abnormal umbilical cord blood vessels (HP:0011403)2.07064460
81Single umbilical artery (HP:0001195)2.07064460
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05638572
83Back pain (HP:0003418)2.04976573
84Premature rupture of membranes (HP:0001788)2.04964524
85Abnormalities of placenta or umbilical cord (HP:0001194)2.02372220
86Pulmonary fibrosis (HP:0002206)2.02349125
87Slender long bone (HP:0003100)2.02059363
88Deviation of the thumb (HP:0009603)2.01550244
89Microglossia (HP:0000171)2.01487744
90Abnormality of carpal bone ossification (HP:0006257)2.00121617
91Distal upper limb amyotrophy (HP:0007149)1.97828532
92Upper limb amyotrophy (HP:0009129)1.97828532
93Abnormality of dentin (HP:0010299)1.97688809
94Ankle contracture (HP:0006466)1.94603257
95Pelvic girdle muscle weakness (HP:0003749)1.93961802
96Hypoplastic pelvis (HP:0008839)1.93740657
97Soft skin (HP:0000977)1.93489188
98Reduced subcutaneous adipose tissue (HP:0003758)1.92009334
99Abnormal ossification of hand bones (HP:0005921)1.91357086
100Abnormality of the intrinsic pathway (HP:0010989)1.91308406
101Syringomyelia (HP:0003396)1.90622557
102Spinal cord lesions (HP:0100561)1.90622557
103Natal tooth (HP:0000695)1.88929944
104Posterior subcapsular cataract (HP:0007787)1.88564180
105Medulloblastoma (HP:0002885)1.87682011
106Short clavicles (HP:0000894)1.87390644
107Poor head control (HP:0002421)1.87128415
108Premature graying of hair (HP:0002216)1.86147634
109Ependymoma (HP:0002888)1.86064703
110Limb-girdle muscle atrophy (HP:0003797)1.85443670
111Proximal placement of thumb (HP:0009623)1.85308715
112Mitral regurgitation (HP:0001653)1.84875687
113Chorioretinal atrophy (HP:0000533)1.82789004
114Tongue fasciculations (HP:0001308)1.80475095
115Postnatal microcephaly (HP:0005484)1.78734787
116Self-mutilation (HP:0000742)1.78572986
117Increased connective tissue (HP:0009025)1.77225133
118Premature skin wrinkling (HP:0100678)1.76943696
119Myopathic facies (HP:0002058)1.76935356
120Secondary amenorrhea (HP:0000869)1.76850195
121Congenital hip dislocation (HP:0001374)1.75051474
122Distal lower limb muscle weakness (HP:0009053)1.75029110
123Increased mean platelet volume (HP:0011877)1.74831152
124Nonimmune hydrops fetalis (HP:0001790)1.74225068
125Squamous cell carcinoma (HP:0002860)1.73846035
126Facial cleft (HP:0002006)1.73727781
127Spinal muscular atrophy (HP:0007269)1.73606107
128Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72850819
129Prominent metopic ridge (HP:0005487)1.72105113
130Abnormality of the 4th metacarpal (HP:0010012)1.70132246
131Bicuspid aortic valve (HP:0001647)1.70128140
132Spastic diplegia (HP:0001264)1.69918707
133Basal cell carcinoma (HP:0002671)1.69338605
134Abnormal mitochondria in muscle tissue (HP:0008316)1.68118586
135Thoracolumbar scoliosis (HP:0002944)1.68105307
136Exercise intolerance (HP:0003546)1.66678173
137Vitreoretinal degeneration (HP:0000655)1.65867719
138Blue sclerae (HP:0000592)1.65787802
139Sparse eyelashes (HP:0000653)1.65732086
140Joint stiffness (HP:0001387)1.65721544
141Wrist flexion contracture (HP:0001239)1.65705909
142Agnosia (HP:0010524)1.65603922
143Radial bowing (HP:0002986)1.64526870
144Megaloblastic anemia (HP:0001889)1.64324455
145Abnormality of the acetabulum (HP:0003170)1.64245853
146Broad face (HP:0000283)1.63995003
147Breech presentation (HP:0001623)1.63958404
148Severe short stature (HP:0003510)1.63934624
149Abnormality of glycolysis (HP:0004366)1.63159337
150Increased serum pyruvate (HP:0003542)1.63159337
151Diminished motivation (HP:0000745)1.62957294
152Fasciculations (HP:0002380)1.62819011
153Long toe (HP:0010511)1.62633627
154Pendular nystagmus (HP:0012043)1.62322543
155Spinal cord compression (HP:0002176)1.62044432
156Muscle fibrillation (HP:0010546)1.61972360
157Cerebral aneurysm (HP:0004944)1.61871326
158Delayed cranial suture closure (HP:0000270)1.61543198
159Flattened epiphyses (HP:0003071)1.60957754
160Dilatation of the ascending aorta (HP:0005111)1.60671836
161Ulnar deviation of the wrist (HP:0003049)1.59954671
162Abnormal trabecular bone morphology (HP:0100671)1.59860029
163Wormian bones (HP:0002645)1.59271075
164Shoulder girdle muscle weakness (HP:0003547)1.59186947
165Insomnia (HP:0100785)1.57851768
166Opisthotonus (HP:0002179)1.57079080
167Death in infancy (HP:0001522)1.56212585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.64523178
2BRSK23.06503052
3TESK22.98877254
4NEK12.92864936
5VRK22.87576197
6WEE12.86352957
7CDC72.78622429
8TESK12.45806179
9EIF2AK12.43180246
10NME22.36963298
11IRAK32.34270460
12NEK22.33393812
13BRSK12.32249888
14SMG12.24798205
15ACVR1B2.21973718
16EEF2K2.18107377
17PAK42.12919015
18PASK1.96435544
19PKN21.92913539
20LIMK11.89912161
21LMTK21.88556359
22TRIB31.88088285
23SCYL21.87186719
24RPS6KA41.84278767
25ICK1.78546369
26MST1R1.70969096
27TTN1.70750104
28TGFBR11.67560330
29RPS6KB21.65029678
30ARAF1.61387434
31CDK71.44674421
32STK161.43923675
33CCNB11.41368606
34PLK11.41058276
35SRPK11.41034612
36AURKB1.37803855
37FLT31.36434086
38PLK31.36357227
39EPHA21.35514443
40ATR1.33059450
41KDR1.32584384
42MAP3K81.32061465
43EIF2AK31.26903264
44DYRK31.26010997
45BRAF1.24745811
46ERN11.21163516
47TSSK61.20100614
48BCKDK1.19468879
49LRRK21.14267805
50STK101.14262867
51PIM21.12742652
52TTK1.10697578
53CDK81.10190817
54DDR21.10118936
55VRK11.06524832
56MAP3K101.03477163
57PAK11.03308777
58MET1.02890232
59ILK1.02303133
60CHEK21.02102744
61TAOK21.01136823
62AURKA1.01075962
63ERBB30.97672107
64CDK40.95756903
65ABL20.94295376
66DMPK0.93031576
67MAP2K70.91471524
68MAP3K110.89816590
69NTRK10.89302619
70PAK20.87999423
71MAPKAPK30.86111557
72MAP4K10.85329005
73SIK10.85148964
74ZAP700.81079371
75CDK120.78725706
76CHEK10.76791298
77ERBB40.73757003
78BRD40.71862788
79BMX0.70892233
80LATS20.70633458
81MAP2K30.70347715
82ZAK0.70216839
83TRPM70.70102287
84CSNK1G30.70008225
85NME10.69523419
86CLK10.67183948
87TLK10.65681795
88TAOK10.64986777
89MKNK10.64342831
90EPHB20.63536653
91MARK30.61723274
92CSNK1G10.60713378
93PDGFRA0.60131149
94RIPK10.59040296
95CDK20.57938500
96CSNK1G20.57020731
97MOS0.55147216
98CDK60.54835257
99DYRK20.53790033
100CDK140.53114441
101PRKCI0.53025363
102PDK20.52707826
103DAPK10.51436283
104CDK90.50925525
105PIM10.50489545
106CDK150.49728338
107CSNK1A1L0.49679016
108CDK180.49655527
109STK40.48615824
110BLK0.48093071
111PTK60.47938610
112CDK11A0.45358008
113MAPKAPK20.45107210
114CSNK2A10.44991055
115MYLK0.43863219
116CSNK2A20.42572576
117PLK40.42350451
118RPS6KA20.41856610
119PRPF4B0.41559611
120PTK20.41418760
121DAPK30.41017283
122ATM0.40616300
123ALK0.40434210
124AKT20.39974194
125MTOR0.38806268
126TAF10.38796651
127EPHB10.37945779
128CDK10.37682971
129MAP3K30.37086748
130RPS6KA50.36871599
131GRK60.36513642
132MAPK110.36151850
133MELK0.35587172
134FGFR10.34684512
135PBK0.31877760

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05814807
2Mismatch repair_Homo sapiens_hsa034303.91611350
3Proteasome_Homo sapiens_hsa030503.72929533
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.20215947
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10441195
6Base excision repair_Homo sapiens_hsa034103.09028199
7One carbon pool by folate_Homo sapiens_hsa006702.97736874
8Spliceosome_Homo sapiens_hsa030402.87485443
9Nucleotide excision repair_Homo sapiens_hsa034202.85409978
10RNA polymerase_Homo sapiens_hsa030202.84077734
11RNA transport_Homo sapiens_hsa030132.78796978
12Ribosome_Homo sapiens_hsa030102.69430473
13Cell cycle_Homo sapiens_hsa041102.64417947
14Pyrimidine metabolism_Homo sapiens_hsa002402.32140570
15Homologous recombination_Homo sapiens_hsa034402.12650429
16p53 signaling pathway_Homo sapiens_hsa041151.71199555
17Fatty acid elongation_Homo sapiens_hsa000621.56418416
18Non-homologous end-joining_Homo sapiens_hsa034501.51749748
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48816530
20Biosynthesis of amino acids_Homo sapiens_hsa012301.46459686
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42482765
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.33037995
23RNA degradation_Homo sapiens_hsa030181.33027016
24N-Glycan biosynthesis_Homo sapiens_hsa005101.27939472
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25840272
26Fanconi anemia pathway_Homo sapiens_hsa034601.23295827
27mRNA surveillance pathway_Homo sapiens_hsa030151.23171834
28Epstein-Barr virus infection_Homo sapiens_hsa051691.22948420
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22620276
30Vitamin B6 metabolism_Homo sapiens_hsa007501.22046893
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22014761
32Purine metabolism_Homo sapiens_hsa002301.21135129
33Pyruvate metabolism_Homo sapiens_hsa006201.17950465
34Sulfur relay system_Homo sapiens_hsa041221.16982484
35Steroid biosynthesis_Homo sapiens_hsa001001.14270980
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.12268966
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08542972
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07482210
39Huntingtons disease_Homo sapiens_hsa050161.07227288
40Systemic lupus erythematosus_Homo sapiens_hsa053221.07129256
41Viral carcinogenesis_Homo sapiens_hsa052031.06810129
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05552333
43Shigellosis_Homo sapiens_hsa051311.05330750
44Parkinsons disease_Homo sapiens_hsa050121.02813428
45Small cell lung cancer_Homo sapiens_hsa052221.02633437
46Other glycan degradation_Homo sapiens_hsa005110.98222676
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98075123
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97285690
49Sulfur metabolism_Homo sapiens_hsa009200.96031781
50Oxidative phosphorylation_Homo sapiens_hsa001900.91326139
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87725098
52Basal transcription factors_Homo sapiens_hsa030220.87460966
53Folate biosynthesis_Homo sapiens_hsa007900.87211479
54Pentose phosphate pathway_Homo sapiens_hsa000300.81662362
55HTLV-I infection_Homo sapiens_hsa051660.81181334
56Phenylalanine metabolism_Homo sapiens_hsa003600.81016600
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80714115
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79651150
59Bladder cancer_Homo sapiens_hsa052190.79304119
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.79296564
61Carbon metabolism_Homo sapiens_hsa012000.77131285
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76443365
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76146252
64MicroRNAs in cancer_Homo sapiens_hsa052060.75532304
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.75053765
66Chronic myeloid leukemia_Homo sapiens_hsa052200.74937240
67Selenocompound metabolism_Homo sapiens_hsa004500.74770751
68Viral myocarditis_Homo sapiens_hsa054160.74069056
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70866423
70Apoptosis_Homo sapiens_hsa042100.69514121
71Oocyte meiosis_Homo sapiens_hsa041140.69513322
72Legionellosis_Homo sapiens_hsa051340.69284752
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67252947
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.63799960
75Herpes simplex infection_Homo sapiens_hsa051680.63646930
76Thyroid cancer_Homo sapiens_hsa052160.62505371
77Alzheimers disease_Homo sapiens_hsa050100.58793366
78Antigen processing and presentation_Homo sapiens_hsa046120.57208479
79Metabolic pathways_Homo sapiens_hsa011000.57024003
80Hippo signaling pathway_Homo sapiens_hsa043900.56376507
81Colorectal cancer_Homo sapiens_hsa052100.55809759
82Hepatitis B_Homo sapiens_hsa051610.55621397
83Glutathione metabolism_Homo sapiens_hsa004800.54344256
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53050827
85Protein export_Homo sapiens_hsa030600.52767804
86Lysosome_Homo sapiens_hsa041420.51812041
87Galactose metabolism_Homo sapiens_hsa000520.49037245
88HIF-1 signaling pathway_Homo sapiens_hsa040660.48999833
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47845705
90Alcoholism_Homo sapiens_hsa050340.47481219
91Notch signaling pathway_Homo sapiens_hsa043300.47356734
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46789152
93Pancreatic cancer_Homo sapiens_hsa052120.45433999
94Prion diseases_Homo sapiens_hsa050200.42986848
95Focal adhesion_Homo sapiens_hsa045100.40473925
96Fatty acid metabolism_Homo sapiens_hsa012120.39842501
97Arginine biosynthesis_Homo sapiens_hsa002200.39161293
98Tyrosine metabolism_Homo sapiens_hsa003500.38458720
99ECM-receptor interaction_Homo sapiens_hsa045120.38202191
100Basal cell carcinoma_Homo sapiens_hsa052170.36833417
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35962727
102Proteoglycans in cancer_Homo sapiens_hsa052050.34667368
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.34168419
104TGF-beta signaling pathway_Homo sapiens_hsa043500.33746686
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33120098
106Melanoma_Homo sapiens_hsa052180.32493134
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31773357
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31666858
109Fructose and mannose metabolism_Homo sapiens_hsa000510.31611591
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30512415
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28427152
112Glioma_Homo sapiens_hsa052140.27981808
113Non-small cell lung cancer_Homo sapiens_hsa052230.27890101
114AMPK signaling pathway_Homo sapiens_hsa041520.26627547
115Vibrio cholerae infection_Homo sapiens_hsa051100.26294022
116Prostate cancer_Homo sapiens_hsa052150.26120494
117Adherens junction_Homo sapiens_hsa045200.24735036
118Pathways in cancer_Homo sapiens_hsa052000.24701935
119Measles_Homo sapiens_hsa051620.24628523
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22588160
121Arginine and proline metabolism_Homo sapiens_hsa003300.20373768
122Influenza A_Homo sapiens_hsa051640.19377325
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18895242
124Phagosome_Homo sapiens_hsa041450.18008074
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17948248
126Salmonella infection_Homo sapiens_hsa051320.15628871
127Renin-angiotensin system_Homo sapiens_hsa046140.14542247
128Acute myeloid leukemia_Homo sapiens_hsa052210.13997760
129mTOR signaling pathway_Homo sapiens_hsa041500.12411392

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