ZDHHC18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.47658067
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.47658067
3positive regulation of gamma-delta T cell activation (GO:0046645)6.44050182
4antigen processing and presentation of endogenous antigen (GO:0019883)6.02463136
5regulation of gamma-delta T cell differentiation (GO:0045586)5.58705492
6negative regulation of cell killing (GO:0031342)5.48571722
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.48571722
8positive thymic T cell selection (GO:0045059)5.32143419
9detection of other organism (GO:0098543)5.24356194
10regulation of gamma-delta T cell activation (GO:0046643)5.18989138
11response to interleukin-15 (GO:0070672)5.03392849
12detection of bacterium (GO:0016045)5.01952609
13negative thymic T cell selection (GO:0045060)5.01022948
14negative T cell selection (GO:0043383)5.00114102
15neutrophil activation involved in immune response (GO:0002283)4.99616641
16macrophage activation involved in immune response (GO:0002281)4.95918955
17response to peptidoglycan (GO:0032494)4.73553950
18thymic T cell selection (GO:0045061)4.73331991
19detection of external biotic stimulus (GO:0098581)4.59341321
20leukocyte aggregation (GO:0070486)4.59092635
21detection of molecule of bacterial origin (GO:0032490)4.58814844
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.54378301
23positive T cell selection (GO:0043368)4.42405481
24interferon-gamma production (GO:0032609)4.41003363
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.38912208
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38358942
27tolerance induction (GO:0002507)4.36529926
28T cell selection (GO:0045058)4.33918453
29cellular response to interleukin-15 (GO:0071350)4.28604844
30regulation of B cell receptor signaling pathway (GO:0050855)4.28250570
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.24839177
32leukocyte migration involved in inflammatory response (GO:0002523)4.21752848
33neutrophil activation (GO:0042119)4.20898568
34respiratory burst (GO:0045730)4.18420716
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17263265
36response to host immune response (GO:0052572)4.17263265
37detection of biotic stimulus (GO:0009595)4.00168012
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.98262080
39T cell migration (GO:0072678)3.98045808
40JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.97625529
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.93017569
42response to host defenses (GO:0052200)3.91044430
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91044430
44response to host (GO:0075136)3.91044430
45negative regulation of leukocyte mediated immunity (GO:0002704)3.87931082
46granulocyte activation (GO:0036230)3.81923578
47B cell receptor signaling pathway (GO:0050853)3.80109573
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.74427185
49microglial cell activation (GO:0001774)3.65692581
50neutrophil mediated immunity (GO:0002446)3.65093900
51NIK/NF-kappaB signaling (GO:0038061)3.64995912
52negative regulation of T cell mediated immunity (GO:0002710)3.60908666
53regulation of mast cell degranulation (GO:0043304)3.57232115
54myeloid cell activation involved in immune response (GO:0002275)3.55042801
55macrophage activation (GO:0042116)3.53134987
56regulation of B cell differentiation (GO:0045577)3.52712252
57production of molecular mediator involved in inflammatory response (GO:0002532)3.50581336
58negative regulation of interleukin-12 production (GO:0032695)3.48715523
59negative regulation of phagocytosis (GO:0050765)3.44888868
60germinal center formation (GO:0002467)3.43766054
61regulation of type I interferon-mediated signaling pathway (GO:0060338)3.43239152
62regulation of isotype switching to IgG isotypes (GO:0048302)3.43057491
63T cell receptor signaling pathway (GO:0050852)3.42908465
64T cell costimulation (GO:0031295)3.42703398
65regulation of T cell tolerance induction (GO:0002664)3.41932481
66positive regulation of histone deacetylation (GO:0031065)3.40728950
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39066439
68antigen receptor-mediated signaling pathway (GO:0050851)3.36325852
69lymphocyte costimulation (GO:0031294)3.35684806
70regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33500793
71positive regulation of B cell differentiation (GO:0045579)3.32938689
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32304907
73positive regulation of humoral immune response (GO:0002922)3.28018093
74regulation of response to interferon-gamma (GO:0060330)3.25285134
75regulation of leukocyte degranulation (GO:0043300)3.25113912
76regulation of mast cell activation involved in immune response (GO:0033006)3.24757267
77leukocyte cell-cell adhesion (GO:0007159)3.23949366
78positive regulation of isotype switching (GO:0045830)3.23767004
79regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.19620038
80positive regulation of tolerance induction (GO:0002645)3.18328793
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17095457
82positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16721923
83leukocyte degranulation (GO:0043299)3.15795500
84regulation of alpha-beta T cell proliferation (GO:0046640)3.15515292
85regulation of T-helper 2 cell differentiation (GO:0045628)3.14381077
86regulation of T cell mediated cytotoxicity (GO:0001914)3.14202396
87myeloid leukocyte mediated immunity (GO:0002444)3.09777332
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09090353
89natural killer cell differentiation (GO:0001779)3.08664153
90positive regulation of interleukin-2 production (GO:0032743)3.08327213
91lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08211377
92positive regulation of mast cell activation (GO:0033005)3.07835326
93regulation of regulatory T cell differentiation (GO:0045589)3.07820135
94dendritic cell chemotaxis (GO:0002407)3.05265354
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01591402
96dendritic cell migration (GO:0036336)3.01457951
97negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.01297430
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01016451
99negative regulation of T-helper cell differentiation (GO:0045623)3.01016451
100mature B cell differentiation (GO:0002335)2.98659296
101negative regulation of innate immune response (GO:0045824)2.97663652
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97425728
103negative regulation of type 2 immune response (GO:0002829)2.97183301
104negative regulation of interleukin-6 production (GO:0032715)2.95868193
105regulation of mast cell activation (GO:0033003)2.95396130
106activated T cell proliferation (GO:0050798)2.94886287
107negative regulation of toll-like receptor signaling pathway (GO:0034122)2.93114520
108positive regulation of immunoglobulin mediated immune response (GO:0002891)2.93021486
109positive regulation of B cell mediated immunity (GO:0002714)2.93021486
110B cell mediated immunity (GO:0019724)2.91499170
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.91331192
112regulation of regulated secretory pathway (GO:1903305)2.87948772
113interferon-gamma-mediated signaling pathway (GO:0060333)2.86851146
114positive regulation of interferon-alpha production (GO:0032727)2.86799573
115endothelial tube morphogenesis (GO:0061154)2.84651733
116morphogenesis of an endothelium (GO:0003159)2.84651733
117response to type I interferon (GO:0034340)2.82584926
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82435359
119regulation of tolerance induction (GO:0002643)2.81761608
120immune response-activating cell surface receptor signaling pathway (GO:0002429)2.81420011
121T cell homeostasis (GO:0043029)2.80098867
122immunoglobulin mediated immune response (GO:0016064)2.79221965
123positive regulation by symbiont of host defense response (GO:0052509)2.75360770
124modulation by symbiont of host defense response (GO:0052031)2.75360770
125modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75360770
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75360770
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.75360770
128modulation by symbiont of host immune response (GO:0052553)2.75360770
129myeloid dendritic cell differentiation (GO:0043011)2.73307679
130cellular response to type I interferon (GO:0071357)2.71344731
131type I interferon signaling pathway (GO:0060337)2.71344731
132positive regulation of immunoglobulin production (GO:0002639)2.70794743
133antigen processing and presentation via MHC class Ib (GO:0002475)2.70681125
134response to protozoan (GO:0001562)2.69758340
135negative regulation of erythrocyte differentiation (GO:0045647)2.68984955
136response to laminar fluid shear stress (GO:0034616)2.68733642
137response to muramyl dipeptide (GO:0032495)2.67539410
138lymphocyte homeostasis (GO:0002260)2.67230157
139T cell proliferation (GO:0042098)2.66251715
140myeloid dendritic cell activation (GO:0001773)2.65982402
141regulation of T cell receptor signaling pathway (GO:0050856)2.65291077
142natural killer cell activation (GO:0030101)2.64997290
143regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64932114
144regulation of natural killer cell mediated immunity (GO:0002715)2.64932114
145regulation of isotype switching (GO:0045191)2.60651460
146cellular extravasation (GO:0045123)2.60519220
147positive regulation of DNA recombination (GO:0045911)2.58582311
148negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58128629
149regulation of immunoglobulin mediated immune response (GO:0002889)2.57960686
150regulation of B cell mediated immunity (GO:0002712)2.57220172
151positive regulation of protein deacetylation (GO:0090312)2.56453816
152defense response to protozoan (GO:0042832)2.55183994
153positive regulation of lamellipodium assembly (GO:0010592)2.55009258
154positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55005087
155regulation of interferon-beta biosynthetic process (GO:0045357)2.54200180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.48583673
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.34224254
3MYC_22102868_ChIP-Seq_BL_Human4.00354316
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.63027133
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.51643312
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45580981
7VDR_21846776_ChIP-Seq_THP-1_Human3.01946285
8E2F7_22180533_ChIP-Seq_HELA_Human2.91715253
9MAF_26560356_Chip-Seq_TH1_Human2.76029886
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75942337
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60367606
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59019528
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53828302
14TCF7_22412390_ChIP-Seq_EML_Mouse2.51729360
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47150165
16RUNX_20019798_ChIP-Seq_JUKART_Human2.47111989
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.45393022
18MYB_26560356_Chip-Seq_TH2_Human2.44866453
19UTX_26944678_Chip-Seq_JUKART_Human2.43873454
20* KDM2B_26808549_Chip-Seq_DND41_Human2.31654685
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28520806
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27553733
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27492062
24MYB_26560356_Chip-Seq_TH1_Human2.24580089
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23874498
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18186747
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17484284
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15007638
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14133957
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13323075
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.11654486
32ELK3_25401928_ChIP-Seq_HUVEC_Human2.06809960
33VDR_24763502_ChIP-Seq_THP-1_Human1.98916877
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96829388
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.93159600
36* MAF_26560356_Chip-Seq_TH2_Human1.92209229
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90713432
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.85920951
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84873646
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82670350
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78532738
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68863022
43SCL_19346495_ChIP-Seq_HPC-7_Human1.63600118
44SPI1_23127762_ChIP-Seq_K562_Human1.63406766
45SPI1_23547873_ChIP-Seq_NB4_Human1.58790074
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.58340170
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50790291
48LXR_22292898_ChIP-Seq_THP-1_Human1.50344928
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.48746614
50GATA3_27048872_Chip-Seq_THYMUS_Human1.47882998
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43787687
52VDR_24787735_ChIP-Seq_THP-1_Human1.35759637
53* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32661915
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30987106
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.29037659
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27781641
57NCOR1_26117541_ChIP-Seq_K562_Human1.25859725
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25385341
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24745723
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24009859
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21718629
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21031532
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19248314
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.19014604
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.17941337
66CIITA_25753668_ChIP-Seq_RAJI_Human1.16839991
67PU_27001747_Chip-Seq_BMDM_Mouse1.15452046
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15056055
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12120951
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11194701
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10365809
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09891034
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07372967
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07234511
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05039744
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04467264
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03987306
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.03346441
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01805849
80* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01678120
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01124385
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00831630
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00705043
84GATA3_26560356_Chip-Seq_TH2_Human1.00451328
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00244404
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97387849
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97043348
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96170024
89ATF3_27146783_Chip-Seq_COLON_Human0.96152608
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95655526
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94295455
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93531040
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.91924734
94PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91173339
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90907163
96GATA1_19941826_ChIP-Seq_K562_Human0.90699219
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90455146
98GATA1_22025678_ChIP-Seq_K562_Human0.90368141
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90040929
100ZNF263_19887448_ChIP-Seq_K562_Human0.89607632
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89431966
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88887439
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88515149
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.86302173
105CTCF_21964334_Chip-Seq_Bcells_Human0.85443249
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.85334319
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85313777
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84952589
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84532638
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84360063
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84342703
112* SA1_27219007_Chip-Seq_ERYTHROID_Human0.84288571
113* KDM2B_26808549_Chip-Seq_K562_Human0.84025422
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83588097
115P68_20966046_ChIP-Seq_HELA_Human0.82626657
116CLOCK_20551151_ChIP-Seq_293T_Human0.82350423
117BCL6_27268052_Chip-Seq_Bcells_Human0.81391593
118SPI1_20517297_ChIP-Seq_HL60_Human0.81166987
119* BCOR_27268052_Chip-Seq_Bcells_Human0.80959422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.86030358
2MP0003763_abnormal_thymus_physiology3.36690410
3MP0000685_abnormal_immune_system3.36057921
4MP0001835_abnormal_antigen_presentation3.31103890
5MP0001800_abnormal_humoral_immune3.19642047
6MP0003436_decreased_susceptibility_to3.15730840
7MP0005387_immune_system_phenotype3.15647108
8MP0001790_abnormal_immune_system3.15647108
9MP0003300_gastrointestinal_ulcer2.97373800
10MP0005671_abnormal_response_to2.92617451
11MP0005000_abnormal_immune_tolerance2.73108036
12MP0004510_myositis2.68823984
13MP0002452_abnormal_antigen_presenting2.60300901
14MP0002723_abnormal_immune_serum2.53761051
15MP0002420_abnormal_adaptive_immunity2.47164412
16MP0001819_abnormal_immune_cell2.44048249
17MP0002398_abnormal_bone_marrow2.37040566
18MP0009785_altered_susceptibility_to2.32549353
19MP0008260_abnormal_autophagy2.26133910
20MP0005025_abnormal_response_to2.26113572
21MP0002405_respiratory_system_inflammati2.18170398
22MP0001873_stomach_inflammation2.12305214
23MP0009278_abnormal_bone_marrow2.12201380
24MP0000716_abnormal_immune_system2.11665814
25MP0004947_skin_inflammation2.08057637
26MP0002166_altered_tumor_susceptibility2.06542718
27MP0010352_gastrointestinal_tract_polyps2.03937006
28MP0009333_abnormal_splenocyte_physiolog2.03622676
29MP0002396_abnormal_hematopoietic_system2.00175532
30MP0002419_abnormal_innate_immunity2.00017977
31MP0002132_abnormal_respiratory_system1.98312213
32MP0010155_abnormal_intestine_physiology1.97920603
33MP0000689_abnormal_spleen_morphology1.96192494
34MP0002722_abnormal_immune_system1.92101886
35MP0006082_CNS_inflammation1.86425740
36MP0005464_abnormal_platelet_physiology1.85794165
37MP0000703_abnormal_thymus_morphology1.82226736
38MP0002277_abnormal_respiratory_mucosa1.76299763
39MP0002429_abnormal_blood_cell1.76266810
40MP0003724_increased_susceptibility_to1.74542958
41MP0003866_abnormal_defecation1.70471463
42MP0002006_tumorigenesis1.70160452
43MP0004808_abnormal_hematopoietic_stem1.69198735
44MP0001845_abnormal_inflammatory_respons1.68924383
45MP0001853_heart_inflammation1.67996528
46MP0004381_abnormal_hair_follicle1.63748261
47MP0002148_abnormal_hypersensitivity_rea1.58890332
48MP0005397_hematopoietic_system_phenotyp1.54587784
49MP0001545_abnormal_hematopoietic_system1.54587784
50MP0005076_abnormal_cell_differentiation1.51971224
51MP0008961_abnormal_basal_metabolism1.50414868
52MP0003183_abnormal_peptide_metabolism1.45824709
53MP0000858_altered_metastatic_potential1.41253159
54MP0001533_abnormal_skeleton_physiology1.41052602
55MP0003448_altered_tumor_morphology1.38851682
56MP0003566_abnormal_cell_adhesion1.36660476
57MP0002933_joint_inflammation1.35969002
58MP0000465_gastrointestinal_hemorrhage1.33555671
59MP0004883_abnormal_blood_vessel1.29500102
60MP0003705_abnormal_hypodermis_morpholog1.28300480
61MP0002138_abnormal_hepatobiliary_system1.24500835
62MP0005023_abnormal_wound_healing1.23040878
63MP0009840_abnormal_foam_cell1.22858616
64MP0008469_abnormal_protein_level1.16253492
65MP0003453_abnormal_keratinocyte_physiol1.09024888
66MP0005310_abnormal_salivary_gland1.08447089
67MP0000490_abnormal_crypts_of1.07259091
68MP0003091_abnormal_cell_migration1.07100222
69MP0005164_abnormal_response_to1.05319860
70MP0003191_abnormal_cellular_cholesterol1.01217594
71MP0002019_abnormal_tumor_incidence1.00971638
72MP0010307_abnormal_tumor_latency0.98310681
73MP0003045_fibrosis0.97863039
74MP0004858_abnormal_nervous_system0.97720722
75MP0004185_abnormal_adipocyte_glucose0.94574441
76MP0001851_eye_inflammation0.93985716
77MP0009764_decreased_sensitivity_to0.92810325
78MP0003690_abnormal_glial_cell0.91110403
79MP0005166_decreased_susceptibility_to0.87512379
80MP0000609_abnormal_liver_physiology0.86450522
81MP0000343_altered_response_to0.82007003
82MP0002998_abnormal_bone_remodeling0.81979088
83MP0003828_pulmonary_edema0.79938813
84MP0010234_abnormal_vibrissa_follicle0.78499698
85MP0003172_abnormal_lysosome_physiology0.78203370
86MP0003221_abnormal_cardiomyocyte_apopto0.77734404
87MP0005058_abnormal_lysosome_morphology0.76778555
88MP0000604_amyloidosis0.76259488
89MP0009763_increased_sensitivity_to0.71127397
90MP0003279_aneurysm0.68570164
91MP0001663_abnormal_digestive_system0.67612701
92MP0000733_abnormal_muscle_development0.67529577
93MP0003075_altered_response_to0.67090953
94MP0000249_abnormal_blood_vessel0.66963804
95MP0003795_abnormal_bone_structure0.65563530
96MP0008004_abnormal_stomach_pH0.64940853
97MP0002136_abnormal_kidney_physiology0.62428450
98MP0009765_abnormal_xenobiotic_induced0.61077832
99MP0005075_abnormal_melanosome_morpholog0.59953383
100MP0000477_abnormal_intestine_morphology0.58734794
101MP0005451_abnormal_body_composition0.57864686
102MP0000598_abnormal_liver_morphology0.57451558
103MP0000350_abnormal_cell_proliferation0.57058541
104MP0008874_decreased_physiological_sensi0.56909805
105MP0001958_emphysema0.55764512
106MP0005377_hearing/vestibular/ear_phenot0.55368613
107MP0003878_abnormal_ear_physiology0.55368613
108MP0005621_abnormal_cell_physiology0.54857183
109MP0003077_abnormal_cell_cycle0.53900799
110MP0002086_abnormal_extraembryonic_tissu0.53824435
111MP0000015_abnormal_ear_pigmentation0.53644505
112MP0002133_abnormal_respiratory_system0.53272140
113MP0005388_respiratory_system_phenotype0.53272140
114MP0005167_abnormal_blood-brain_barrier0.52940875
115MP0003656_abnormal_erythrocyte_physiolo0.52934134
116MP0001986_abnormal_taste_sensitivity0.52838625
117MP0003806_abnormal_nucleotide_metabolis0.51643878
118MP0005390_skeleton_phenotype0.51315801
119MP0009931_abnormal_skin_appearance0.51018427
120MP0004130_abnormal_muscle_cell0.50838638
121MP0008873_increased_physiological_sensi0.49940142
122MP0000371_diluted_coat_color0.49303498
123MP0002877_abnormal_melanocyte_morpholog0.48997112

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.53727928
2Recurrent bronchitis (HP:0002837)4.19244172
3Chronic otitis media (HP:0000389)4.11222050
4Nasal polyposis (HP:0100582)4.09988626
5Recurrent fungal infections (HP:0002841)4.02062346
6T lymphocytopenia (HP:0005403)3.96320330
7Abnormality of the nasal mucosa (HP:0000433)3.93577286
8Recurrent viral infections (HP:0004429)3.90398491
9Hypochromic microcytic anemia (HP:0004840)3.87453844
10Keratoconjunctivitis sicca (HP:0001097)3.85453042
11Abnormality of T cell number (HP:0011839)3.80179645
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.75405669
13Elevated erythrocyte sedimentation rate (HP:0003565)3.74173007
14Stomatitis (HP:0010280)3.64112168
15IgM deficiency (HP:0002850)3.59448732
16Urticaria (HP:0001025)3.56243073
17Myositis (HP:0100614)3.56167835
18Keratoconjunctivitis (HP:0001096)3.51215070
19Hypochromic anemia (HP:0001931)3.51133271
20Cellulitis (HP:0100658)3.47845849
21Pustule (HP:0200039)3.46611379
22Recurrent abscess formation (HP:0002722)3.46200629
23Autoimmune thrombocytopenia (HP:0001973)3.42436980
24Panhypogammaglobulinemia (HP:0003139)3.41002967
25Abnormality of T cells (HP:0002843)3.40750778
26Spontaneous hematomas (HP:0007420)3.31527028
27Abnormality of the fingertips (HP:0001211)3.30301327
28Papilloma (HP:0012740)3.27237703
29Verrucae (HP:0200043)3.27237703
30Mediastinal lymphadenopathy (HP:0100721)3.26553291
31Inflammation of the large intestine (HP:0002037)3.22420227
32Peritonitis (HP:0002586)3.19960620
33Agammaglobulinemia (HP:0004432)3.19938587
34Gastrointestinal inflammation (HP:0004386)3.19665559
35Colitis (HP:0002583)3.15669759
36Meningitis (HP:0001287)3.14616730
37Chronic mucocutaneous candidiasis (HP:0002728)3.07268746
38Recurrent cutaneous fungal infections (HP:0011370)3.07268746
39Vasculitis (HP:0002633)3.05253985
40Episodic fever (HP:0001954)3.04558392
41Recurrent bacterial skin infections (HP:0005406)3.02345468
42Increased IgE level (HP:0003212)3.01507022
43Interstitial pulmonary disease (HP:0006530)3.00946204
44Gastrointestinal stroma tumor (HP:0100723)2.85813701
45Emphysema (HP:0002097)2.84727009
46Anorexia (HP:0002039)2.77841625
47Abnormality of T cell physiology (HP:0011840)2.74296959
48Increased density of long bones (HP:0006392)2.73370894
49Lymphopenia (HP:0001888)2.72274060
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.66702813
51Increased IgM level (HP:0003496)2.61509395
52Recurrent gram-negative bacterial infections (HP:0005420)2.60161539
53Orchitis (HP:0100796)2.59492871
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57688310
55Recurrent skin infections (HP:0001581)2.55234218
56Chronic obstructive pulmonary disease (HP:0006510)2.54913973
57Obstructive lung disease (HP:0006536)2.54913973
58IgA deficiency (HP:0002720)2.46150836
59Amyloidosis (HP:0011034)2.46081894
60Abnormality of the peritoneum (HP:0002585)2.45789011
61Microcytic anemia (HP:0001935)2.45359546
62Pulmonary infiltrates (HP:0002113)2.43260319
63Sepsis (HP:0100806)2.41992368
64Arterial thrombosis (HP:0004420)2.40187758
65Combined immunodeficiency (HP:0005387)2.40105036
66Retrobulbar optic neuritis (HP:0100654)2.39805363
67Optic neuritis (HP:0100653)2.39805363
68Basal cell carcinoma (HP:0002671)2.39024903
69Hematochezia (HP:0002573)2.36787381
70Recurrent sinusitis (HP:0011108)2.36385206
71Abnormal platelet volume (HP:0011876)2.34440918
72Chest pain (HP:0100749)2.33628266
73Cerebral aneurysm (HP:0004944)2.32971050
74Petechiae (HP:0000967)2.31241000
75Abnormality of the pleura (HP:0002103)2.30856958
76Segmental peripheral demyelination/remyelination (HP:0003481)2.28518913
77Hemoptysis (HP:0002105)2.28452437
78Gangrene (HP:0100758)2.28147940
79Prolonged bleeding time (HP:0003010)2.26437218
80Slow saccadic eye movements (HP:0000514)2.25832963
81Bronchitis (HP:0012387)2.25608556
82Restrictive lung disease (HP:0002091)2.23552096
83Abnormality of macrophages (HP:0004311)2.22465293
84Myocardial infarction (HP:0001658)2.21974096
85Chronic sinusitis (HP:0011109)2.21203356
86Thrombocytosis (HP:0001894)2.20877967
87Osteomyelitis (HP:0002754)2.20352142
88Joint swelling (HP:0001386)2.18629436
89Abnormality of the endocardium (HP:0004306)2.17660633
90Glomerulopathy (HP:0100820)2.17479440
91Subacute progressive viral hepatitis (HP:0006572)2.16788237
92Epistaxis (HP:0000421)2.16718529
93Leukocytosis (HP:0001974)2.16113316
94Pulmonary embolism (HP:0002204)2.14378358
95Premature loss of primary teeth (HP:0006323)2.12614100
96IgG deficiency (HP:0004315)2.11601502
97Gingival bleeding (HP:0000225)2.10696986
98Gastrointestinal infarctions (HP:0005244)2.09837881
99Severe combined immunodeficiency (HP:0004430)2.09504833
100Encephalitis (HP:0002383)2.08993683
101Abnormality of B cell number (HP:0010975)2.08634960
102B lymphocytopenia (HP:0010976)2.08634960
103Metaphyseal cupping (HP:0003021)2.07842823
104Frequent falls (HP:0002359)2.07216770
105Viral hepatitis (HP:0006562)2.06745558
106Acne (HP:0001061)2.05201756
107Eosinophilia (HP:0001880)2.05129217
108Skin ulcer (HP:0200042)2.02837789
109Polycythemia (HP:0001901)2.02574651
110Abnormality of the pericardium (HP:0001697)2.01435840
111Hepatosplenomegaly (HP:0001433)2.00284864
112Gingivitis (HP:0000230)1.98994400
113Impaired platelet aggregation (HP:0003540)1.98929296
114Abnormal platelet function (HP:0011869)1.98929296
115Lymphoma (HP:0002665)1.97270149
116Persistence of primary teeth (HP:0006335)1.96853136
117Keratitis (HP:0000491)1.96080189
118Increased mean platelet volume (HP:0011877)1.95798907
119Acute hepatic failure (HP:0006554)1.94363755
120Purpura (HP:0000979)1.92656644
121Abnormality of eosinophils (HP:0001879)1.91157231
122Hypermelanotic macule (HP:0001034)1.91130405
123Periodontitis (HP:0000704)1.91046843
124Loss of speech (HP:0002371)1.87833148
125Aortic aneurysm (HP:0004942)1.83940850
126Increased serum ferritin (HP:0003281)1.83573446
127Hyperacusis (HP:0010780)1.83157619
128Recurrent pneumonia (HP:0006532)1.80423824
129Chronic diarrhea (HP:0002028)1.80280792
130Vertigo (HP:0002321)1.79664576
131Thyroiditis (HP:0100646)1.79019579
132Hypergammaglobulinemia (HP:0010702)1.78593666
133Ulnar bowing (HP:0003031)1.76176544
134Skin rash (HP:0000988)1.76016623
135Granulocytopenia (HP:0001913)1.75788260
136Cheilitis (HP:0100825)1.74303480
137Arthralgia (HP:0002829)1.73237111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.07220379
2MAP3K103.06336230
3TRIB32.86931729
4TXK2.69434553
5EEF2K2.65984590
6PRPF4B2.55912507
7STK102.53154915
8JAK32.50448836
9ERN12.50113318
10TYK22.38710664
11FGFR42.38051904
12PKN22.34309248
13GRK62.32474956
14ZAP702.12659186
15JAK11.96428297
16ITK1.95395011
17EPHB11.86923725
18MAP3K31.86874861
19LRRK21.83404983
20TBK11.80778981
21MAP3K141.78720614
22CDK121.77228916
23IKBKE1.69692021
24FGFR31.62426671
25CSK1.56280682
26MAP3K131.53716476
27SMG11.51269868
28BTK1.47395551
29SIK21.46985424
30MAP2K31.42260600
31HCK1.36376258
32TTN1.32209969
33TAOK11.32106479
34ALK1.29823332
35SYK1.26845382
36BLK1.25597914
37MARK31.25451660
38YES11.23547162
39LCK1.23528324
40TGFBR21.17672345
41PTK61.17375669
42IKBKB1.12963665
43TAOK21.10004015
44IRAK21.09478890
45EPHA31.09327475
46JAK21.08816836
47PIM11.06240391
48IRAK11.05923615
49MAP3K71.04025376
50RIPK41.02185268
51RPS6KA41.00811098
52KIT0.99519353
53FES0.99098351
54TEC0.98168763
55CSF1R0.97185336
56PRKCH0.95360154
57NLK0.90508090
58CHUK0.90130310
59CLK10.88750434
60SIK10.87707660
61IRAK30.87484270
62CDK40.87465069
63MATK0.84029862
64KSR20.83947866
65RIPK10.82976670
66MAP3K60.82250380
67PDPK10.80989469
68MAP3K20.74938815
69IRAK40.71237702
70CDC42BPA0.69778407
71BMX0.67939048
72CDK190.65326968
73DYRK1B0.64324326
74MAP3K80.64173245
75STK380.63404029
76RET0.63368883
77FYN0.63287218
78TAOK30.63017467
79PRKD20.62734467
80MAP2K40.61453917
81NEK20.61407182
82PRKCQ0.61064853
83PDK10.59616221
84MAP3K110.59510676
85TNK20.58996203
86CDK60.57355140
87HIPK20.57070739
88LYN0.56625372
89STK110.56124883
90KDR0.55448647
91NME20.55176202
92RAF10.53559883
93TYRO30.53381505
94PRKG20.51501072
95PTK2B0.51130799
96KSR10.49668577
97RPS6KC10.49308006
98RPS6KL10.49308006
99MAP3K10.49203159
100PDGFRB0.48849037
101CAMKK10.47939699
102DMPK0.47908752
103MAP3K50.46669746
104TGFBR10.46296044
105CDK90.45761542
106EGFR0.44220890
107MARK20.44101554
108MTOR0.43548781
109BMPR20.43150829
110MELK0.42947785
111MAPK110.42874779
112MAPK70.42140770
113MAPKAPK20.40659838
114FLT30.39727614
115RPS6KB20.36574280
116FGR0.35974795
117MAPK120.35304233
118MAP3K90.35138994
119PRKCZ0.34482601
120TESK20.33972728
121MAPK40.33476182
122MAP2K60.33420286
123BRD40.31949701
124STK40.31433111
125ABL10.31237629
126SGK30.31002363
127SIK30.30834797
128CAMK1D0.29445670
129PRKD10.27584335
130RPS6KA60.27569826

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.63508835
2B cell receptor signaling pathway_Homo sapiens_hsa046622.83640800
3T cell receptor signaling pathway_Homo sapiens_hsa046602.62566829
4Leishmaniasis_Homo sapiens_hsa051402.50057645
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.41953357
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37845861
7Osteoclast differentiation_Homo sapiens_hsa043802.35417344
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17696030
9Measles_Homo sapiens_hsa051622.11297794
10Antigen processing and presentation_Homo sapiens_hsa046121.93328765
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.88262830
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83296580
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81325122
14Acute myeloid leukemia_Homo sapiens_hsa052211.75440685
15Hematopoietic cell lineage_Homo sapiens_hsa046401.75290128
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.68403546
17Toxoplasmosis_Homo sapiens_hsa051451.68073668
18Chronic myeloid leukemia_Homo sapiens_hsa052201.64095199
19Allograft rejection_Homo sapiens_hsa053301.59079806
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56095625
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53587538
22Graft-versus-host disease_Homo sapiens_hsa053321.52863078
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50936598
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50556588
25TNF signaling pathway_Homo sapiens_hsa046681.45684004
26Chemokine signaling pathway_Homo sapiens_hsa040621.44302910
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.41748558
28Staphylococcus aureus infection_Homo sapiens_hsa051501.39800321
29Viral myocarditis_Homo sapiens_hsa054161.37827564
30Hepatitis B_Homo sapiens_hsa051611.37600706
31Herpes simplex infection_Homo sapiens_hsa051681.36943904
32Shigellosis_Homo sapiens_hsa051311.36034268
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35662755
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30687875
35VEGF signaling pathway_Homo sapiens_hsa043701.30421223
36Phagosome_Homo sapiens_hsa041451.29872450
37Pancreatic cancer_Homo sapiens_hsa052121.29259470
38Influenza A_Homo sapiens_hsa051641.26557617
39Apoptosis_Homo sapiens_hsa042101.25878335
40Tuberculosis_Homo sapiens_hsa051521.25429728
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.23929851
42Prolactin signaling pathway_Homo sapiens_hsa049171.20225526
43Platelet activation_Homo sapiens_hsa046111.14635640
44Non-small cell lung cancer_Homo sapiens_hsa052231.12944217
45Asthma_Homo sapiens_hsa053101.09717398
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07908832
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07601068
48mTOR signaling pathway_Homo sapiens_hsa041501.04800815
49Malaria_Homo sapiens_hsa051441.02862951
50Legionellosis_Homo sapiens_hsa051341.02801383
51Pertussis_Homo sapiens_hsa051331.00355487
52HTLV-I infection_Homo sapiens_hsa051660.98313164
53Hepatitis C_Homo sapiens_hsa051600.97895226
54Other glycan degradation_Homo sapiens_hsa005110.95509745
55Small cell lung cancer_Homo sapiens_hsa052220.95494631
56Salmonella infection_Homo sapiens_hsa051320.92075471
57Insulin resistance_Homo sapiens_hsa049310.92041147
58Colorectal cancer_Homo sapiens_hsa052100.87602339
59Epstein-Barr virus infection_Homo sapiens_hsa051690.86586981
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.85483433
61Dorso-ventral axis formation_Homo sapiens_hsa043200.84219534
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82540282
63HIF-1 signaling pathway_Homo sapiens_hsa040660.76712563
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76458834
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76175569
66Viral carcinogenesis_Homo sapiens_hsa052030.75677565
67Renal cell carcinoma_Homo sapiens_hsa052110.74771330
68Notch signaling pathway_Homo sapiens_hsa043300.73539755
69FoxO signaling pathway_Homo sapiens_hsa040680.70731109
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69377883
71Proteoglycans in cancer_Homo sapiens_hsa052050.69349134
72GnRH signaling pathway_Homo sapiens_hsa049120.69272163
73Autoimmune thyroid disease_Homo sapiens_hsa053200.68847659
74Endometrial cancer_Homo sapiens_hsa052130.68173293
75MicroRNAs in cancer_Homo sapiens_hsa052060.67067005
76MAPK signaling pathway_Homo sapiens_hsa040100.66934245
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66473292
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64097174
79African trypanosomiasis_Homo sapiens_hsa051430.63310559
80ErbB signaling pathway_Homo sapiens_hsa040120.63004773
81Endocytosis_Homo sapiens_hsa041440.62690734
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62603777
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61212936
84Rheumatoid arthritis_Homo sapiens_hsa053230.60570362
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58485063
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57817378
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57509497
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.56778940
89Amoebiasis_Homo sapiens_hsa051460.56580904
90Lysine degradation_Homo sapiens_hsa003100.54792567
91Glioma_Homo sapiens_hsa052140.53757122
92Insulin signaling pathway_Homo sapiens_hsa049100.53073987
93Type II diabetes mellitus_Homo sapiens_hsa049300.51908386
94Lysosome_Homo sapiens_hsa041420.51850893
95Type I diabetes mellitus_Homo sapiens_hsa049400.51161938
96Thyroid cancer_Homo sapiens_hsa052160.50448622
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49959053
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.49860796
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.49809586
100Prostate cancer_Homo sapiens_hsa052150.48610002
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47718154
102Estrogen signaling pathway_Homo sapiens_hsa049150.47426979
103Focal adhesion_Homo sapiens_hsa045100.45243638
104Rap1 signaling pathway_Homo sapiens_hsa040150.45183799
105Adherens junction_Homo sapiens_hsa045200.45065663
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44533225
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43162809
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.43032309
109p53 signaling pathway_Homo sapiens_hsa041150.40383763
110Choline metabolism in cancer_Homo sapiens_hsa052310.38052157
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36616376
112Pathways in cancer_Homo sapiens_hsa052000.34961535
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34432092
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33634432
115Bladder cancer_Homo sapiens_hsa052190.33586900

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