ZDHHC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucokinase activity (GO:0033131)4.93556856
2regulation of hexokinase activity (GO:1903299)4.93556856
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78486067
4inositol phosphate catabolic process (GO:0071545)4.68547072
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61695697
6protein maturation by protein folding (GO:0022417)4.43675490
7phosphorylated carbohydrate dephosphorylation (GO:0046838)4.40403214
8inositol phosphate dephosphorylation (GO:0046855)4.40403214
9regulation of synaptic vesicle exocytosis (GO:2000300)4.32902166
10detection of calcium ion (GO:0005513)4.25692274
11negative regulation of hormone biosynthetic process (GO:0032353)4.23322174
12synaptic vesicle exocytosis (GO:0016079)4.20002830
13lactate metabolic process (GO:0006089)4.19145482
14positive regulation of protein autophosphorylation (GO:0031954)4.18726521
15neuron cell-cell adhesion (GO:0007158)4.16719537
16positive regulation of glycolytic process (GO:0045821)4.15482987
17synaptic vesicle maturation (GO:0016188)4.14111386
18polyol catabolic process (GO:0046174)4.06084542
19Golgi transport vesicle coating (GO:0048200)3.91861824
20COPI coating of Golgi vesicle (GO:0048205)3.91861824
21cellular ketone body metabolic process (GO:0046950)3.91282226
22regulation of synaptic vesicle transport (GO:1902803)3.72806419
23neuronal action potential propagation (GO:0019227)3.71721549
24insulin secretion (GO:0030073)3.71055379
25nodal signaling pathway (GO:0038092)3.69284905
26xenobiotic catabolic process (GO:0042178)3.68840797
27signal peptide processing (GO:0006465)3.65993322
28negative regulation of hormone metabolic process (GO:0032351)3.63559441
29nitric oxide mediated signal transduction (GO:0007263)3.63355573
30negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.63287993
31respiratory chain complex IV assembly (GO:0008535)3.63053395
32ketone body metabolic process (GO:1902224)3.59836806
33glutamate secretion (GO:0014047)3.59649296
34innervation (GO:0060384)3.57522162
35response to pheromone (GO:0019236)3.53440879
36locomotory exploration behavior (GO:0035641)3.48751307
37epithelial cell fate commitment (GO:0072148)3.48665407
38glycerophospholipid catabolic process (GO:0046475)3.44212944
39vocalization behavior (GO:0071625)3.39143810
40negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38313196
41regulation of protein glycosylation (GO:0060049)3.36356375
42neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.36267663
43parental behavior (GO:0060746)3.32604709
44chemosensory behavior (GO:0007635)3.30862071
45endocrine pancreas development (GO:0031018)3.30680875
46protein localization to synapse (GO:0035418)3.30061580
47activation of protein kinase A activity (GO:0034199)3.27673968
48cytochrome complex assembly (GO:0017004)3.26522305
49water-soluble vitamin biosynthetic process (GO:0042364)3.23230447
50regulation of energy homeostasis (GO:2000505)3.22581111
51negative regulation of protein oligomerization (GO:0032460)3.22542069
52positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.21409766
53protein targeting to Golgi (GO:0000042)3.21304996
54protein prenylation (GO:0018342)3.20934286
55prenylation (GO:0097354)3.20934286
56proline transport (GO:0015824)3.15981654
57membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.12546543
58neurotransmitter secretion (GO:0007269)3.11527839
59negative regulation of neurological system process (GO:0031645)3.09786435
60neuron recognition (GO:0008038)3.09494672
61dentate gyrus development (GO:0021542)3.09316061
62positive regulation of gluconeogenesis (GO:0045722)3.07700672
63exploration behavior (GO:0035640)3.07095400
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06463877
65vesicle transport along microtubule (GO:0047496)3.05161768
66layer formation in cerebral cortex (GO:0021819)3.04103880
67peptide hormone processing (GO:0016486)3.03078930
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01604967
69regulation of vesicle fusion (GO:0031338)3.00365118
70regulation of insulin secretion (GO:0050796)2.99815935
71positive regulation of peptide hormone secretion (GO:0090277)2.99449636
72positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99157551
73type B pancreatic cell development (GO:0003323)2.99033091
74negative regulation of norepinephrine secretion (GO:0010700)2.96729386
75regulation of calcium ion-dependent exocytosis (GO:0017158)2.96174557
76magnesium ion transport (GO:0015693)2.95897520
77brain morphogenesis (GO:0048854)2.95868227
78ER overload response (GO:0006983)2.95030881
79presynaptic membrane assembly (GO:0097105)2.92587241
80cerebellar Purkinje cell layer development (GO:0021680)2.90193643
81regulation of neuronal synaptic plasticity (GO:0048168)2.89397434
82positive regulation of exocytosis (GO:0045921)2.89132409
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88780237
84L-fucose catabolic process (GO:0042355)2.88736751
85fucose catabolic process (GO:0019317)2.88736751
86L-fucose metabolic process (GO:0042354)2.88736751
87retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88552788
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87693863
89regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87556463
90organelle transport along microtubule (GO:0072384)2.87506235
91transmission of nerve impulse (GO:0019226)2.85686786
92positive regulation of peptide secretion (GO:0002793)2.85652810
93regulation of protein autophosphorylation (GO:0031952)2.84585792
94negative regulation of activin receptor signaling pathway (GO:0032926)2.84500699
95membrane depolarization during action potential (GO:0086010)2.84163144
96regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83439058
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82872695
98zinc ion transport (GO:0006829)2.82654485
99establishment of protein localization to Golgi (GO:0072600)2.82396918
100regulation of type B pancreatic cell apoptotic process (GO:2000674)2.81382689
101positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.81310440
102membrane repolarization during action potential (GO:0086011)2.80168282
103righting reflex (GO:0060013)2.78919266
104regulation of glutamate receptor signaling pathway (GO:1900449)2.78587285
105cellular response to glucagon stimulus (GO:0071377)2.78197939
106postsynaptic membrane organization (GO:0001941)2.77879502
107negative regulation of execution phase of apoptosis (GO:1900118)2.77427252
108Golgi to endosome transport (GO:0006895)2.77282179
109synapse assembly (GO:0007416)2.76800316
110peptide hormone secretion (GO:0030072)2.76599463
111axonal fasciculation (GO:0007413)2.76378045
112signal transduction involved in regulation of gene expression (GO:0023019)2.73337147
113platelet dense granule organization (GO:0060155)2.73159887
114axon cargo transport (GO:0008088)2.73136905
115membrane repolarization (GO:0086009)2.73063587
116inner ear receptor cell development (GO:0060119)2.72637267
117atrial cardiac muscle cell action potential (GO:0086014)2.72376225
118macroautophagy (GO:0016236)2.72307634
119calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71714167
120neuron-neuron synaptic transmission (GO:0007270)2.71446393
121regulation of neurotransmitter secretion (GO:0046928)2.71394074
122zinc ion homeostasis (GO:0055069)2.71222109
123keratinocyte development (GO:0003334)2.70890225
124suckling behavior (GO:0001967)2.70676135
125positive regulation of potassium ion transport (GO:0043268)2.70566356
126negative regulation of dendrite morphogenesis (GO:0050774)2.70538650
127regulation of peptide hormone secretion (GO:0090276)2.70490956
128synaptic transmission, glutamatergic (GO:0035249)2.70259409
129negative regulation of catecholamine secretion (GO:0033604)2.69988933
130cell migration in hindbrain (GO:0021535)2.69391333
131regulation of neurotransmitter uptake (GO:0051580)2.68511375
132synaptic vesicle docking involved in exocytosis (GO:0016081)2.68300952
133regulation of peptide secretion (GO:0002791)2.68288287
134dendrite morphogenesis (GO:0048813)2.68281609
135peptide secretion (GO:0002790)2.68225982
136vascular smooth muscle contraction (GO:0014829)2.67924999
137somite rostral/caudal axis specification (GO:0032525)2.67913589
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67439604
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67318166
140neurotransmitter transport (GO:0006836)2.67003297
141positive regulation of actin filament depolymerization (GO:0030836)2.66781088
142retrograde transport, vesicle recycling within Golgi (GO:0000301)2.66676179
143mating behavior (GO:0007617)2.65487784
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65135445
145axoneme assembly (GO:0035082)2.64819956
146regulation of exocytosis (GO:0017157)2.64462354
147cerebellar Purkinje cell differentiation (GO:0021702)2.64197809
148maternal behavior (GO:0042711)2.62737284
149dendritic spine morphogenesis (GO:0060997)2.62611014
150synaptic vesicle transport (GO:0048489)2.62285462
151establishment of synaptic vesicle localization (GO:0097480)2.62285462
152regulation of Rac protein signal transduction (GO:0035020)2.61165259
153ionotropic glutamate receptor signaling pathway (GO:0035235)2.60605855
154positive regulation of insulin secretion (GO:0032024)2.60540022
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.59325085
156glandular epithelial cell differentiation (GO:0002067)2.59296698
157positive regulation of meiosis (GO:0045836)2.57783219
158cell communication by electrical coupling (GO:0010644)2.57271619
159intra-Golgi vesicle-mediated transport (GO:0006891)2.57081905
160neuronal action potential (GO:0019228)2.56982801
161regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56901187
162fatty acid homeostasis (GO:0055089)2.56890092
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55290373
164establishment of vesicle localization (GO:0051650)2.55265747
165calcium ion-dependent exocytosis (GO:0017156)2.55016864
166regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.54866999
167glandular epithelial cell development (GO:0002068)2.52895991
168prostate gland growth (GO:0060736)2.52509629
169kidney morphogenesis (GO:0060993)2.51158574
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50067744
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.49731021
172positive regulation of macroautophagy (GO:0016239)2.48099424
173phospholipid dephosphorylation (GO:0046839)2.44921822
174neuron fate determination (GO:0048664)2.42205454
175early endosome to late endosome transport (GO:0045022)2.41929084
176negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.40094534
177positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.38698410
178positive regulation of carbohydrate metabolic process (GO:0045913)2.37387188
179pancreas development (GO:0031016)2.37054860
180positive regulation of hormone secretion (GO:0046887)2.36951047
181protein localization to Golgi apparatus (GO:0034067)2.36559378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.30587149
2GBX2_23144817_ChIP-Seq_PC3_Human3.52199518
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83906718
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78665049
5REST_21632747_ChIP-Seq_MESCs_Mouse2.70202048
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65945692
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64404447
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.44530696
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37838600
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.35227824
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34467609
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31154202
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28866694
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22200418
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21546373
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21546373
17TAF15_26573619_Chip-Seq_HEK293_Human2.14949980
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10623629
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.07135800
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05187463
21IGF1R_20145208_ChIP-Seq_DFB_Human2.02801247
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01824468
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00225839
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.97698528
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.95492537
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.95180811
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94312747
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93302702
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.92066941
30ZNF274_21170338_ChIP-Seq_K562_Hela1.91518463
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91217186
32SMAD4_21799915_ChIP-Seq_A2780_Human1.87680206
33NR3C1_23031785_ChIP-Seq_PC12_Mouse1.85871652
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82341952
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80373377
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80320184
37DROSHA_22980978_ChIP-Seq_HELA_Human1.78865865
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75070909
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73097276
40EWS_26573619_Chip-Seq_HEK293_Human1.72444889
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69352870
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65630983
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.65191371
44P300_19829295_ChIP-Seq_ESCs_Human1.61598903
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61017130
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59241185
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58195960
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57512062
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.56786102
50STAT3_23295773_ChIP-Seq_U87_Human1.56589204
51ER_23166858_ChIP-Seq_MCF-7_Human1.55086172
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53151447
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.51553403
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49794293
55P53_22387025_ChIP-Seq_ESCs_Mouse1.49262180
56VDR_22108803_ChIP-Seq_LS180_Human1.49176996
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48984591
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46470087
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.43877409
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41150956
61CDX2_22108803_ChIP-Seq_LS180_Human1.40402031
62AR_21572438_ChIP-Seq_LNCaP_Human1.38855355
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.37320399
64CBP_20019798_ChIP-Seq_JUKART_Human1.37246303
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37246303
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37012164
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36489044
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.34589975
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34302862
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.34059802
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.33876142
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33296422
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31387330
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28474830
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28474830
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28322794
77NANOG_19829295_ChIP-Seq_ESCs_Human1.27450964
78SOX2_19829295_ChIP-Seq_ESCs_Human1.27450964
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26897933
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.26556061
81AR_25329375_ChIP-Seq_VCAP_Human1.26403400
82TCF4_23295773_ChIP-Seq_U87_Human1.24804205
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24400000
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24027396
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23150669
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22917292
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22610064
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.22302565
89TCF4_22108803_ChIP-Seq_LS180_Human1.20988780
90* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20726501
91TP53_22573176_ChIP-Seq_HFKS_Human1.20088532
92P300_18555785_Chip-Seq_ESCs_Mouse1.19809316
93BCAT_22108803_ChIP-Seq_LS180_Human1.19742218
94RNF2_27304074_Chip-Seq_NSC_Mouse1.19525999
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17577394
96* AR_19668381_ChIP-Seq_PC3_Human1.17027334
97FUS_26573619_Chip-Seq_HEK293_Human1.15961621
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15860440
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15083070
100RUNX2_22187159_ChIP-Seq_PCA_Human1.14845327
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.14410087
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.13876623
103* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13773519
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.11739214
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.10504128
106AHR_22903824_ChIP-Seq_MCF-7_Human1.09856693
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09582248
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09400744
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09338368
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.08998967
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08955802
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08431413
113HTT_18923047_ChIP-ChIP_STHdh_Human1.08384006
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07754702
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.07378455
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07233581
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06929558
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.06688660
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.05968530
120CTCF_18555785_Chip-Seq_ESCs_Mouse1.04893846
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04802744
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03444528
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02832988
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02703896
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02678402
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02440251
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.01581773
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01462136
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.01462136
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00719152
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00620102
132WT1_19549856_ChIP-ChIP_CCG9911_Human1.00334299
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99855233
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99419839
135JUN_21703547_ChIP-Seq_K562_Human0.99296041
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99196694
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.98504527
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98045311
139PU1_27457419_Chip-Seq_LIVER_Mouse0.97645471
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97135769
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97014308
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.96983959
143TBL1_22424771_ChIP-Seq_293T_Human0.96502869
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95951880
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95487923
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.93514267
147SMAD_19615063_ChIP-ChIP_OVARY_Human0.92940104
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.91724859
149GATA1_22025678_ChIP-Seq_K562_Human0.90901342
150RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90740308
151KDM2B_26808549_Chip-Seq_REH_Human0.89414224
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.88940079
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88536493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.95470920
2MP0004859_abnormal_synaptic_plasticity3.68823058
3MP0010234_abnormal_vibrissa_follicle3.48526622
4MP0009780_abnormal_chondrocyte_physiolo3.48363669
5MP0002909_abnormal_adrenal_gland3.10129256
6MP0003880_abnormal_central_pattern3.09343257
7MP0003635_abnormal_synaptic_transmissio2.87279114
8MP0002735_abnormal_chemical_nociception2.84107687
9MP0008877_abnormal_DNA_methylation2.78267306
10MP0002734_abnormal_mechanical_nocicepti2.75030096
11MP0001968_abnormal_touch/_nociception2.73798239
12MP0002733_abnormal_thermal_nociception2.49852014
13MP0003283_abnormal_digestive_organ2.46591090
14MP0006276_abnormal_autonomic_nervous2.40049589
15MP0010386_abnormal_urinary_bladder2.32144239
16MP0002063_abnormal_learning/memory/cond2.28771703
17MP0000013_abnormal_adipose_tissue2.21335756
18MP0006054_spinal_hemorrhage2.19513910
19MP0002736_abnormal_nociception_after2.16796932
20MP0001986_abnormal_taste_sensitivity2.16364851
21MP0009745_abnormal_behavioral_response2.13732192
22MP0001970_abnormal_pain_threshold2.12503919
23MP0002693_abnormal_pancreas_physiology2.10247795
24MP0005379_endocrine/exocrine_gland_phen2.09995416
25MP0004858_abnormal_nervous_system2.06974295
26MP0002572_abnormal_emotion/affect_behav2.06585581
27MP0002254_reproductive_system_inflammat2.05392647
28MP0002877_abnormal_melanocyte_morpholog2.04482764
29MP0002837_dystrophic_cardiac_calcinosis2.03394409
30MP0002272_abnormal_nervous_system2.03268809
31MP0002064_seizures2.01474896
32MP0003183_abnormal_peptide_metabolism2.00502063
33MP0001661_extended_life_span2.00295527
34MP0005423_abnormal_somatic_nervous1.84693685
35MP0001944_abnormal_pancreas_morphology1.83667352
36MP0003122_maternal_imprinting1.83010384
37MP0004043_abnormal_pH_regulation1.80745364
38MP0006072_abnormal_retinal_apoptosis1.79268498
39MP0002184_abnormal_innervation1.79101284
40MP0009046_muscle_twitch1.77217339
41MP0002067_abnormal_sensory_capabilities1.71069480
42MP0003011_delayed_dark_adaptation1.67247328
43MP0005645_abnormal_hypothalamus_physiol1.64129119
44MP0005646_abnormal_pituitary_gland1.62782758
45MP0001486_abnormal_startle_reflex1.61975531
46MP0002638_abnormal_pupillary_reflex1.58714712
47MP0003329_amyloid_beta_deposits1.57767070
48MP0010352_gastrointestinal_tract_polyps1.56604374
49MP0010678_abnormal_skin_adnexa1.55096004
50MP0000516_abnormal_urinary_system1.54564818
51MP0005367_renal/urinary_system_phenotyp1.54564818
52MP0002102_abnormal_ear_morphology1.52691015
53MP0001440_abnormal_grooming_behavior1.52278576
54MP0000955_abnormal_spinal_cord1.51670097
55MP0002557_abnormal_social/conspecific_i1.50947459
56MP0001501_abnormal_sleep_pattern1.50845849
57MP0000778_abnormal_nervous_system1.49539035
58MP0010329_abnormal_lipoprotein_level1.45152214
59MP0004924_abnormal_behavior1.44670658
60MP0005386_behavior/neurological_phenoty1.44670658
61MP0004811_abnormal_neuron_physiology1.42148910
62MP0001984_abnormal_olfaction1.42088604
63MP0001188_hyperpigmentation1.41104870
64MP0003121_genomic_imprinting1.40105803
65MP0005084_abnormal_gallbladder_morpholo1.38671850
66MP0000678_abnormal_parathyroid_gland1.36298572
67MP0000427_abnormal_hair_cycle1.31898478
68MP0003879_abnormal_hair_cell1.28902537
69MP0001756_abnormal_urination1.28583327
70MP0003123_paternal_imprinting1.27882752
71MP0002882_abnormal_neuron_morphology1.27668677
72MP0003787_abnormal_imprinting1.27120454
73MP0004145_abnormal_muscle_electrophysio1.26988960
74MP0000631_abnormal_neuroendocrine_gland1.25647019
75MP0001529_abnormal_vocalization1.25365786
76MP0005636_abnormal_mineral_homeostasis1.24230417
77MP0005174_abnormal_tail_pigmentation1.22946082
78MP0004215_abnormal_myocardial_fiber1.19289736
79MP0002822_catalepsy1.19250239
80MP0008569_lethality_at_weaning1.19183556
81MP0002163_abnormal_gland_morphology1.19083209
82MP0001299_abnormal_eye_distance/1.18380130
83MP0005332_abnormal_amino_acid1.15410222
84MP0002229_neurodegeneration1.15051980
85MP0005551_abnormal_eye_electrophysiolog1.14849750
86MP0004133_heterotaxia1.12361514
87MP0008995_early_reproductive_senescence1.12269018
88MP0002078_abnormal_glucose_homeostasis1.12149576
89MP0003172_abnormal_lysosome_physiology1.11718478
90MP0002928_abnormal_bile_duct1.10426548
91MP0002066_abnormal_motor_capabilities/c1.10133708
92MP0001502_abnormal_circadian_rhythm1.07652146
93MP0005535_abnormal_body_temperature1.07626681
94MP0003195_calcinosis1.05606254
95MP0002751_abnormal_autonomic_nervous1.04669900
96MP0005075_abnormal_melanosome_morpholog1.04394872
97MP0004134_abnormal_chest_morphology1.03179420
98MP0005253_abnormal_eye_physiology1.02798213
99MP0008961_abnormal_basal_metabolism1.02677022
100MP0001905_abnormal_dopamine_level1.01725003
101MP0004019_abnormal_vitamin_homeostasis1.00276883
102MP0003634_abnormal_glial_cell0.98067945
103MP0002090_abnormal_vision0.97628832
104MP0002876_abnormal_thyroid_physiology0.96198658
105MP0006036_abnormal_mitochondrial_physio0.95044472
106MP0002166_altered_tumor_susceptibility0.94388439
107MP0005448_abnormal_energy_balance0.93832878
108MP0000639_abnormal_adrenal_gland0.93198885
109MP0002234_abnormal_pharynx_morphology0.92027668
110MP0000372_irregular_coat_pigmentation0.90539110
111MP0002295_abnormal_pulmonary_circulatio0.89955439
112MP0003890_abnormal_embryonic-extraembry0.88580012
113MP0002069_abnormal_eating/drinking_beha0.86983078
114MP0003633_abnormal_nervous_system0.86908290
115MP0003656_abnormal_erythrocyte_physiolo0.85547961
116MP0003786_premature_aging0.85186206
117MP0002971_abnormal_brown_adipose0.81857506
118MP0004742_abnormal_vestibular_system0.81805244
119MP0002152_abnormal_brain_morphology0.81179398
120MP0001270_distended_abdomen0.80757580
121MP0003953_abnormal_hormone_level0.80375679
122MP0000613_abnormal_salivary_gland0.79738663
123MP0005187_abnormal_penis_morphology0.79619212
124MP0002118_abnormal_lipid_homeostasis0.79464534
125MP0003045_fibrosis0.79425524
126MP0000003_abnormal_adipose_tissue0.79079228
127MP0004885_abnormal_endolymph0.77891225
128MP0000383_abnormal_hair_follicle0.77590228
129MP0002752_abnormal_somatic_nervous0.77370142
130MP0005389_reproductive_system_phenotype0.76975850
131MP0008775_abnormal_heart_ventricle0.76684839
132MP0008872_abnormal_physiological_respon0.76632504
133MP0004085_abnormal_heartbeat0.76573948
134MP0002896_abnormal_bone_mineralization0.75800778
135MP0001664_abnormal_digestion0.74160583
136MP0000462_abnormal_digestive_system0.73305075
137MP0002938_white_spotting0.73293815
138MP0004142_abnormal_muscle_tone0.73069315
139MP0001963_abnormal_hearing_physiology0.72055986
140MP0000569_abnormal_digit_pigmentation0.71817584
141MP0009697_abnormal_copulation0.71583145
142MP0005220_abnormal_exocrine_pancreas0.71204098
143MP0001485_abnormal_pinna_reflex0.70652083
144MP0001765_abnormal_ion_homeostasis0.70510531
145MP0003868_abnormal_feces_composition0.70335060
146MP0003631_nervous_system_phenotype0.70263764
147MP0000538_abnormal_urinary_bladder0.68878582
148MP0004484_altered_response_of0.68450830
149MP0002139_abnormal_hepatobiliary_system0.67414520
150MP0002160_abnormal_reproductive_system0.65398925
151MP0000230_abnormal_systemic_arterial0.64498696
152MP0004147_increased_porphyrin_level0.62405632

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.84582085
2Visual hallucinations (HP:0002367)4.72505109
3Focal motor seizures (HP:0011153)4.41986714
4Hyperinsulinemic hypoglycemia (HP:0000825)4.15785239
5Pheochromocytoma (HP:0002666)3.81712171
6Myokymia (HP:0002411)3.80196874
7Papilledema (HP:0001085)3.61249491
8Atonic seizures (HP:0010819)3.60306919
9Focal seizures (HP:0007359)3.53570097
10Abnormality of calcium-phosphate metabolism (HP:0100530)3.52502450
11Hematochezia (HP:0002573)3.40997088
12Neuroendocrine neoplasm (HP:0100634)3.38885071
13Hypoglycemic seizures (HP:0002173)3.35683323
14Agitation (HP:0000713)3.32489720
15Double outlet right ventricle (HP:0001719)3.31300086
16Congenital malformation of the right heart (HP:0011723)3.31300086
17Enlarged penis (HP:0000040)3.25604591
18Symptomatic seizures (HP:0011145)3.19385981
19Epileptic encephalopathy (HP:0200134)3.10440395
20Neoplasm of the adrenal cortex (HP:0100641)3.10342581
21Limb dystonia (HP:0002451)3.08926297
22Hypothermia (HP:0002045)3.08345934
23Absence seizures (HP:0002121)3.08252693
24Epileptiform EEG discharges (HP:0011182)3.04449242
25EEG with generalized epileptiform discharges (HP:0011198)3.04189902
26Febrile seizures (HP:0002373)3.02589300
27Action tremor (HP:0002345)3.01552476
28Hypomagnesemia (HP:0002917)3.00391820
29Intestinal atresia (HP:0011100)2.95562627
30Hypsarrhythmia (HP:0002521)2.94297873
31Progressive cerebellar ataxia (HP:0002073)2.92135184
32Supranuclear gaze palsy (HP:0000605)2.90421926
33Conjunctival hamartoma (HP:0100780)2.88341239
34Abnormality of vitamin B metabolism (HP:0004340)2.84353184
35Tongue fasciculations (HP:0001308)2.81236683
36Insulin-resistant diabetes mellitus (HP:0000831)2.79787587
37Dialeptic seizures (HP:0011146)2.79205927
38Methylmalonic acidemia (HP:0002912)2.78913089
39Truncal ataxia (HP:0002078)2.77729263
40Ketosis (HP:0001946)2.77618443
41Failure to thrive in infancy (HP:0001531)2.76364598
42Generalized tonic-clonic seizures (HP:0002069)2.74985182
43Medial flaring of the eyebrow (HP:0010747)2.72461942
44Disproportionate short-trunk short stature (HP:0003521)2.65038148
45Decreased circulating renin level (HP:0003351)2.64894646
46Abnormal rod and cone electroretinograms (HP:0008323)2.63062286
47Pancreatic fibrosis (HP:0100732)2.61330539
48Aqueductal stenosis (HP:0002410)2.55907582
49Hyperglycemia (HP:0003074)2.54119695
50Increased CSF protein (HP:0002922)2.53740531
51Thyroiditis (HP:0100646)2.52333256
52Termporal pattern (HP:0011008)2.48883039
53Insidious onset (HP:0003587)2.48883039
54Hemiparesis (HP:0001269)2.47921543
55Molar tooth sign on MRI (HP:0002419)2.47832642
56Abnormality of midbrain morphology (HP:0002418)2.47832642
57Hamartoma of the eye (HP:0010568)2.46264065
58Hypercortisolism (HP:0001578)2.46250287
59Muscle fibrillation (HP:0010546)2.45986787
60Neoplasm of the adrenal gland (HP:0100631)2.45546085
61Anxiety (HP:0000739)2.45345183
62Calf muscle hypertrophy (HP:0008981)2.45166252
63Furrowed tongue (HP:0000221)2.43421499
64Ankle clonus (HP:0011448)2.40579671
65Abnormality of the renal cortex (HP:0011035)2.40356677
66Depression (HP:0000716)2.38728402
67Metaphyseal dysplasia (HP:0100255)2.37443416
68Postural tremor (HP:0002174)2.36925128
69Cerebral inclusion bodies (HP:0100314)2.32967140
70Amblyopia (HP:0000646)2.31687632
71Hyperparathyroidism (HP:0000843)2.31191876
72Pancreatic cysts (HP:0001737)2.31142826
73Nephronophthisis (HP:0000090)2.30897861
74Renal cortical cysts (HP:0000803)2.30886055
75True hermaphroditism (HP:0010459)2.30186026
76Dysautonomia (HP:0002459)2.29739394
77Large for gestational age (HP:0001520)2.28037777
78Neurofibrillary tangles (HP:0002185)2.27698657
79Hypoplasia of the fovea (HP:0007750)2.22098827
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.22098827
81Abnormality of endocrine pancreas physiology (HP:0012093)2.21583648
82Abnormality of the pancreatic islet cells (HP:0006476)2.21583648
83Mucopolysacchariduria (HP:0008155)2.19388365
84Urinary glycosaminoglycan excretion (HP:0003541)2.19388365
85Abnormal pancreas size (HP:0012094)2.18508125
86Ulnar claw (HP:0001178)2.18490422
87Pancreatic islet-cell hyperplasia (HP:0004510)2.18135551
88Ketoacidosis (HP:0001993)2.17552274
89Polydipsia (HP:0001959)2.16382740
90Abnormal drinking behavior (HP:0030082)2.16382740
91Muscle hypertrophy of the lower extremities (HP:0008968)2.14620839
92Stomatitis (HP:0010280)2.12633236
93Drooling (HP:0002307)2.12628409
94Excessive salivation (HP:0003781)2.12628409
95Abnormality of vitamin metabolism (HP:0100508)2.09692533
96Type II lissencephaly (HP:0007260)2.08942805
97Hyperphosphatemia (HP:0002905)2.07923476
98Gait imbalance (HP:0002141)2.07794567
99Vascular calcification (HP:0004934)2.06963672
100Prominent metopic ridge (HP:0005487)2.06232700
101Abnormal sex determination (HP:0012244)2.05828881
102Sex reversal (HP:0012245)2.05828881
103Impaired smooth pursuit (HP:0007772)2.04647336
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04426811
105Abnormality of polysaccharide metabolism (HP:0011012)2.04426811
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04426811
107Abnormality of the corticospinal tract (HP:0002492)2.04089367
108Thoracolumbar scoliosis (HP:0002944)2.03282839
109Menstrual irregularities (HP:0000858)2.02586894
110Neoplasm of the peripheral nervous system (HP:0100007)2.01724268
111Abnormality of the fovea (HP:0000493)2.01569731
112Megalencephaly (HP:0001355)2.01445906
113Urethral obstruction (HP:0000796)2.01387992
114Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00979359
115Attenuation of retinal blood vessels (HP:0007843)1.97326179
116Abnormality of abdominal situs (HP:0011620)1.96070386
117Abdominal situs inversus (HP:0003363)1.96070386
118Central scotoma (HP:0000603)1.96038152
119Abnormality of magnesium homeostasis (HP:0004921)1.95958836
120Progressive macrocephaly (HP:0004481)1.95255105
121Hypokalemia (HP:0002900)1.95216480
122Hypoventilation (HP:0002791)1.95166400
123Hypoglycemic coma (HP:0001325)1.95075994
124Methylmalonic aciduria (HP:0012120)1.93075104
125Spastic gait (HP:0002064)1.91816062
126Hyperthyroidism (HP:0000836)1.90671258
127Retinal atrophy (HP:0001105)1.90477497
128Retinal dysplasia (HP:0007973)1.89796362
129Dysostosis multiplex (HP:0000943)1.89724898
130Downturned corners of mouth (HP:0002714)1.89400207
131Abnormality of the renal medulla (HP:0100957)1.88953414
132Restlessness (HP:0000711)1.88271199
133Abnormal albumin level (HP:0012116)1.86984100
134Hypoalbuminemia (HP:0003073)1.86984100
135Late onset (HP:0003584)1.83943426
136Cardiovascular calcification (HP:0011915)1.83297227
137Genital tract atresia (HP:0001827)1.82802540
138Congenital glaucoma (HP:0001087)1.82590826
139Abnormality of the metopic suture (HP:0005556)1.82401175
140Resting tremor (HP:0002322)1.82389262
141Goiter (HP:0000853)1.82193515
142Increased circulating renin level (HP:0000848)1.81764673
143Thyroid carcinoma (HP:0002890)1.79721770
144Urinary bladder sphincter dysfunction (HP:0002839)1.79702969
145Muscular hypotonia of the trunk (HP:0008936)1.79115710
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78317493
147Hypoplasia of the brainstem (HP:0002365)1.78317493
148Vaginal atresia (HP:0000148)1.77895558
149Nephrogenic diabetes insipidus (HP:0009806)1.77803210
150Bradykinesia (HP:0002067)1.77207554
151Hyperventilation (HP:0002883)1.76863220
152Abnormality of pain sensation (HP:0010832)1.76512830
153Impaired pain sensation (HP:0007328)1.76512830
154Intention tremor (HP:0002080)1.75873238
155Poor eye contact (HP:0000817)1.75770227
156Polyphagia (HP:0002591)1.74355323
157Abnormal autonomic nervous system physiology (HP:0012332)1.74238061
158Congenital stationary night blindness (HP:0007642)1.73299882
159Gaze-evoked nystagmus (HP:0000640)1.72482620
160Impaired vibration sensation in the lower limbs (HP:0002166)1.72143612
161Abnormality of renin-angiotensin system (HP:0000847)1.70941933
162Testicular neoplasm (HP:0010788)1.70646355
163Delayed gross motor development (HP:0002194)1.70238733
164Akinesia (HP:0002304)1.69304931
165Congenital primary aphakia (HP:0007707)1.68807285
166Progressive inability to walk (HP:0002505)1.68786200
167Absent speech (HP:0001344)1.68190487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.42084490
2INSRR3.90592391
3FGFR23.45579461
4MST43.21221315
5MARK13.20288096
6MAP3K92.93921130
7NTRK12.91526548
8MAP3K22.89821162
9ACVR1B2.55442041
10PRKD32.51440178
11MAP3K42.47160914
12MINK12.43925247
13CASK2.38110979
14MAP4K22.31404345
15NLK2.16531096
16MAP2K72.09967961
17GRK12.07029047
18PASK1.99915411
19EPHA41.93630421
20CAMKK21.92529575
21KSR21.89953623
22FRK1.85704099
23GRK51.80194539
24HIPK21.77676400
25PNCK1.75482929
26FGFR31.73449075
27UHMK11.70713278
28PINK11.68508118
29EIF2AK31.57179682
30ADRBK21.56409550
31MAP3K121.55017846
32NUAK11.51125847
33RET1.50531736
34TRPM71.48423379
35MAPK131.47619899
36TAOK31.45363101
37SCYL21.44340602
38MAP3K11.43900415
39PTK2B1.42830296
40MAP2K41.37139374
41CDK51.31298001
42WNK41.30520349
43NTRK21.29986177
44STK31.27737620
45CAMKK11.27374115
46PAK61.27357358
47RIPK41.19797344
48ARAF1.17513662
49CSNK1G11.15967199
50STK241.14609504
51PLK21.13667079
52MKNK21.11621021
53PRKCH1.08209225
54CSNK1G21.07017807
55TEC1.05381904
56OXSR11.05238109
57MAPK151.04159330
58TAF11.03990069
59DAPK21.03360417
60CDC42BPA1.01586641
61PAK31.01577399
62PHKG11.01383155
63PHKG21.01383155
64KSR10.98250835
65PRKCG0.97346316
66FER0.94565641
67PRKCE0.93329501
68AKT30.90888821
69PLK30.89538271
70CAMK2A0.89301475
71MAP2K60.88353840
72EIF2AK10.88353832
73WNK30.87348165
74CAMK2B0.86550295
75STK38L0.85999280
76TRIM280.85087736
77OBSCN0.84855957
78SGK2230.83896243
79SGK4940.83896243
80CAMK2D0.81266197
81BMPR20.79858835
82PRKAA20.77068233
83RPS6KA20.76570459
84TNIK0.74472774
85PTK20.74103340
86WNK10.73671223
87BCR0.73286906
88LATS20.70085964
89SGK20.70064409
90LIMK10.69311882
91SIK20.69147579
92PDGFRA0.67994974
93FLT30.66724980
94CDK140.66169914
95BRSK20.65721903
96IRAK20.64258421
97DAPK10.61984197
98DYRK1A0.61806121
99BMPR1B0.60456739
100ADRBK10.59114129
101MARK20.58107344
102EPHA30.57825262
103IRAK10.57750807
104MAP2K10.57278121
105NEK10.56441225
106TNK20.55771570
107CSNK1G30.55043460
108NME10.54339700
109ERBB30.54238144
110BRAF0.52189481
111PRKAA10.51804433
112DYRK20.51767219
113LMTK20.50073298
114CDK180.50061203
115JAK10.48796376
116FES0.48023517
117NEK90.47640714
118YES10.47257930
119PRKG10.47163944
120STK380.46303455
121CDK150.45739893
122STK110.45123878
123PRKD20.44935832
124SGK10.44924874
125PRKACA0.44765363
126CAMK1G0.43925956
127STK390.43181177
128STK40.41299705
129BRSK10.40964265
130SIK30.40581621
131CSNK1A1L0.38021662
132SGK30.37957523
133PRKCI0.37329207
134MAPK100.36547296
135ROCK10.36474989
136ITK0.36462203
137PRKCZ0.36313369
138RPS6KA30.36132230
139RPS6KB10.35784767
140CDK11A0.35575914
141ZAK0.34618230
142PRKCQ0.34315467
143PIK3CG0.32893526
144ROCK20.30124534
145CDK30.28209770
146TYK20.27700689
147GSK3A0.27630744
148TIE10.27102455
149VRK10.27057400
150EGFR0.23294603
151PRKACB0.22829509

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.04038114
2Butanoate metabolism_Homo sapiens_hsa006503.02692049
3Insulin secretion_Homo sapiens_hsa049112.97842633
4Synaptic vesicle cycle_Homo sapiens_hsa047212.71513029
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53699882
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33112034
7Long-term potentiation_Homo sapiens_hsa047202.26279803
8Amphetamine addiction_Homo sapiens_hsa050312.24990464
9Nicotine addiction_Homo sapiens_hsa050332.22958482
10Dopaminergic synapse_Homo sapiens_hsa047282.14193710
11Taste transduction_Homo sapiens_hsa047422.14048167
12Vitamin B6 metabolism_Homo sapiens_hsa007502.12824200
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10307694
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04499701
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.03820568
16Circadian entrainment_Homo sapiens_hsa047132.02836193
17GABAergic synapse_Homo sapiens_hsa047272.01542276
18Cocaine addiction_Homo sapiens_hsa050301.94362190
19Type II diabetes mellitus_Homo sapiens_hsa049301.91631388
20Protein export_Homo sapiens_hsa030601.90033877
21Cholinergic synapse_Homo sapiens_hsa047251.83296750
22Glutamatergic synapse_Homo sapiens_hsa047241.81199070
23Morphine addiction_Homo sapiens_hsa050321.81187281
24Vibrio cholerae infection_Homo sapiens_hsa051101.77626614
25Serotonergic synapse_Homo sapiens_hsa047261.77467188
26Olfactory transduction_Homo sapiens_hsa047401.76721784
27Fatty acid elongation_Homo sapiens_hsa000621.64586572
28Collecting duct acid secretion_Homo sapiens_hsa049661.60833504
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55949538
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53674322
31Propanoate metabolism_Homo sapiens_hsa006401.52032512
32Phototransduction_Homo sapiens_hsa047441.51146628
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49707362
34Renin secretion_Homo sapiens_hsa049241.46590332
35Peroxisome_Homo sapiens_hsa041461.43469226
36Type I diabetes mellitus_Homo sapiens_hsa049401.43340719
37Salivary secretion_Homo sapiens_hsa049701.42222530
38Long-term depression_Homo sapiens_hsa047301.41784545
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40555755
40Ether lipid metabolism_Homo sapiens_hsa005651.39267469
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38309287
42Tryptophan metabolism_Homo sapiens_hsa003801.35008420
43Selenocompound metabolism_Homo sapiens_hsa004501.30237833
44Gastric acid secretion_Homo sapiens_hsa049711.27511123
45Sulfur metabolism_Homo sapiens_hsa009201.26484441
46Pancreatic secretion_Homo sapiens_hsa049721.23975478
47Fatty acid metabolism_Homo sapiens_hsa012121.21236183
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20930089
49Estrogen signaling pathway_Homo sapiens_hsa049151.20077957
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17253979
51Gap junction_Homo sapiens_hsa045401.16257290
52Folate biosynthesis_Homo sapiens_hsa007901.13019452
53GnRH signaling pathway_Homo sapiens_hsa049121.12100457
54Oxytocin signaling pathway_Homo sapiens_hsa049211.08962722
55Sphingolipid metabolism_Homo sapiens_hsa006001.08366267
56Dorso-ventral axis formation_Homo sapiens_hsa043201.07248101
57Fatty acid degradation_Homo sapiens_hsa000711.04952525
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04195952
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03467903
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03081168
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02467011
62Thyroid hormone synthesis_Homo sapiens_hsa049181.00325702
63Calcium signaling pathway_Homo sapiens_hsa040201.00022951
64Melanogenesis_Homo sapiens_hsa049160.96316901
65Mineral absorption_Homo sapiens_hsa049780.95382930
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.93699108
67cAMP signaling pathway_Homo sapiens_hsa040240.93498139
68Glucagon signaling pathway_Homo sapiens_hsa049220.90211088
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89708242
70Alzheimers disease_Homo sapiens_hsa050100.89382115
71Glioma_Homo sapiens_hsa052140.87945650
72Cardiac muscle contraction_Homo sapiens_hsa042600.85512366
73Basal transcription factors_Homo sapiens_hsa030220.85362377
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.81362176
75Axon guidance_Homo sapiens_hsa043600.80233981
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79466903
77Oxidative phosphorylation_Homo sapiens_hsa001900.78832682
78Nitrogen metabolism_Homo sapiens_hsa009100.77151080
79ABC transporters_Homo sapiens_hsa020100.76464807
80ErbB signaling pathway_Homo sapiens_hsa040120.75132254
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.74830245
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73706364
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71523349
84Prolactin signaling pathway_Homo sapiens_hsa049170.70773812
85Oocyte meiosis_Homo sapiens_hsa041140.70255910
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68801814
87Circadian rhythm_Homo sapiens_hsa047100.68720157
88Alcoholism_Homo sapiens_hsa050340.68467239
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.66956060
90Insulin signaling pathway_Homo sapiens_hsa049100.65943712
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64822394
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64039723
93N-Glycan biosynthesis_Homo sapiens_hsa005100.63416346
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61650527
95Parkinsons disease_Homo sapiens_hsa050120.61316276
96mTOR signaling pathway_Homo sapiens_hsa041500.60580697
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60279369
98beta-Alanine metabolism_Homo sapiens_hsa004100.59716654
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59102091
100Endometrial cancer_Homo sapiens_hsa052130.57498535
101Prion diseases_Homo sapiens_hsa050200.56107342
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55443193
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54322240
104Regulation of autophagy_Homo sapiens_hsa041400.52062384
105Lysosome_Homo sapiens_hsa041420.51796593
106Inositol phosphate metabolism_Homo sapiens_hsa005620.50902668
107MAPK signaling pathway_Homo sapiens_hsa040100.49575304
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.48994413
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48582919
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47892409
111Linoleic acid metabolism_Homo sapiens_hsa005910.47343941
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.47145145
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47012378
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.46715819
115Glutathione metabolism_Homo sapiens_hsa004800.46686646
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46438890
117Choline metabolism in cancer_Homo sapiens_hsa052310.46096939
118Ras signaling pathway_Homo sapiens_hsa040140.46058435
119VEGF signaling pathway_Homo sapiens_hsa043700.45249419
120Dilated cardiomyopathy_Homo sapiens_hsa054140.44599331
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44401262
122FoxO signaling pathway_Homo sapiens_hsa040680.43383547
123Renal cell carcinoma_Homo sapiens_hsa052110.43262789
124RNA degradation_Homo sapiens_hsa030180.41819958
125Insulin resistance_Homo sapiens_hsa049310.40757462
126Wnt signaling pathway_Homo sapiens_hsa043100.40144126
127Retinol metabolism_Homo sapiens_hsa008300.37552903
128Melanoma_Homo sapiens_hsa052180.37071552
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37018561
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36691687
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36413074
132Thyroid cancer_Homo sapiens_hsa052160.36401717
133Metabolic pathways_Homo sapiens_hsa011000.35042440
134Endocytosis_Homo sapiens_hsa041440.34727213
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34565093
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33979094
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33202217
138Huntingtons disease_Homo sapiens_hsa050160.32906206
139Ovarian steroidogenesis_Homo sapiens_hsa049130.32781279
140Purine metabolism_Homo sapiens_hsa002300.31386177
141Platelet activation_Homo sapiens_hsa046110.30535873

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