ZDHHC20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.14104772
2long-chain fatty acid biosynthetic process (GO:0042759)5.41887087
3myelination (GO:0042552)5.33291912
4ensheathment of neurons (GO:0007272)5.31742229
5axon ensheathment (GO:0008366)5.31742229
6negative regulation of neurotransmitter transport (GO:0051589)4.61380040
7negative regulation of neurotransmitter secretion (GO:0046929)4.54122966
8myelin maintenance (GO:0043217)4.54086599
9nuclear pore complex assembly (GO:0051292)4.52374770
10embryonic process involved in female pregnancy (GO:0060136)4.48489301
11negative regulation of protein localization to cell surface (GO:2000009)4.18384179
12positive regulation of oligodendrocyte differentiation (GO:0048714)4.15657488
13L-amino acid import (GO:0043092)4.04696063
14regulation of collateral sprouting (GO:0048670)3.88974199
15import into cell (GO:0098657)3.77909971
16nuclear pore organization (GO:0006999)3.72296252
17amyloid precursor protein metabolic process (GO:0042982)3.69315009
18response to lipoprotein particle (GO:0055094)3.61957081
19oligodendrocyte differentiation (GO:0048709)3.61869773
20response to methylmercury (GO:0051597)3.58648586
21limb bud formation (GO:0060174)3.48305275
22histone H3-K36 demethylation (GO:0070544)3.47188570
23photoreceptor cell differentiation (GO:0046530)3.46556653
24eye photoreceptor cell differentiation (GO:0001754)3.46556653
25protein localization to endosome (GO:0036010)3.46461382
26presynaptic membrane organization (GO:0097090)3.45013060
27isoprenoid biosynthetic process (GO:0008299)3.44939361
28cholesterol biosynthetic process (GO:0006695)3.39357231
29hypotonic response (GO:0006971)3.36230493
30positive regulation of gamma-delta T cell activation (GO:0046645)3.32503719
31glycerophospholipid catabolic process (GO:0046475)3.31189686
32negative regulation of execution phase of apoptosis (GO:1900118)3.23786944
33presynaptic membrane assembly (GO:0097105)3.20357182
34regulation of lipoprotein metabolic process (GO:0050746)3.18015756
35pore complex assembly (GO:0046931)3.17389555
36hepatocyte apoptotic process (GO:0097284)3.17213728
37neuron remodeling (GO:0016322)3.13986806
38negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08832625
39GPI anchor biosynthetic process (GO:0006506)3.03265305
40amino acid import (GO:0043090)3.02170309
41establishment of mitochondrion localization (GO:0051654)3.00305003
42asymmetric protein localization (GO:0008105)2.99901187
43sterol biosynthetic process (GO:0016126)2.98350572
44cerebral cortex radially oriented cell migration (GO:0021799)2.96410546
45positive regulation of glial cell differentiation (GO:0045687)2.96372767
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96047441
47organ growth (GO:0035265)2.93524666
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92653829
49negative regulation of cell killing (GO:0031342)2.92653829
50regulation of pigment cell differentiation (GO:0050932)2.90576289
51positive regulation of Cdc42 GTPase activity (GO:0043089)2.90088982
52negative regulation of DNA repair (GO:0045738)2.89814256
53preassembly of GPI anchor in ER membrane (GO:0016254)2.86667413
54astrocyte development (GO:0014002)2.86425512
55response to redox state (GO:0051775)2.85892664
56magnesium ion transport (GO:0015693)2.82835180
57GPI anchor metabolic process (GO:0006505)2.82427258
58positive regulation by symbiont of host defense response (GO:0052509)2.81827916
59modulation by symbiont of host defense response (GO:0052031)2.81827916
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81827916
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81827916
62positive regulation by organism of defense response of other organism involved in symbiotic interact2.81827916
63modulation by symbiont of host immune response (GO:0052553)2.81827916
64epithelial cell differentiation involved in prostate gland development (GO:0060742)2.81338293
65extracellular matrix assembly (GO:0085029)2.79028029
66response to peptidoglycan (GO:0032494)2.79003677
67peptidyl-tyrosine autophosphorylation (GO:0038083)2.73439988
68positive regulation of gliogenesis (GO:0014015)2.73275785
69leukocyte migration involved in inflammatory response (GO:0002523)2.73187737
70creatine metabolic process (GO:0006600)2.72719779
71detection of other organism (GO:0098543)2.72332407
72definitive hemopoiesis (GO:0060216)2.71508321
73apical protein localization (GO:0045176)2.71357358
74mitotic sister chromatid cohesion (GO:0007064)2.70259617
75trophectodermal cell differentiation (GO:0001829)2.69790474
76protein neddylation (GO:0045116)2.68849396
77response to laminar fluid shear stress (GO:0034616)2.67750598
78mRNA stabilization (GO:0048255)2.67077897
79RNA stabilization (GO:0043489)2.67077897
80negative regulation of erythrocyte differentiation (GO:0045647)2.65198849
81necroptotic process (GO:0070266)2.60189697
82phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.59928038
83axon development (GO:0061564)2.58001531
84developmental pigmentation (GO:0048066)2.57702506
85neurotransmitter uptake (GO:0001504)2.56429462
86cytoplasmic mRNA processing body assembly (GO:0033962)2.53820196
87positive regulation of actin filament depolymerization (GO:0030836)2.52021802
88regulation of somitogenesis (GO:0014807)2.51229496
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50177848
90Golgi transport vesicle coating (GO:0048200)2.48797531
91COPI coating of Golgi vesicle (GO:0048205)2.48797531
92membrane raft organization (GO:0031579)2.48776355
93detection of molecule of bacterial origin (GO:0032490)2.48344789
94nucleotide transmembrane transport (GO:1901679)2.46958805
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46686995
96negative regulation of exocytosis (GO:0045920)2.46616958
97embryonic camera-type eye morphogenesis (GO:0048596)2.43935622
98regulation of gamma-delta T cell activation (GO:0046643)2.41948338
99positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.41179270
100peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.40912289
101mast cell activation (GO:0045576)2.40218918
102positive regulation of keratinocyte differentiation (GO:0045618)2.40174972
103mammary gland epithelial cell proliferation (GO:0033598)2.39871003
104activation of Rac GTPase activity (GO:0032863)2.39541907
105cellular protein complex localization (GO:0034629)2.39476650
106branch elongation of an epithelium (GO:0060602)2.39419166
107adult walking behavior (GO:0007628)2.39296373
108negative regulation of fatty acid transport (GO:2000192)2.39268674
109regulation of RNA export from nucleus (GO:0046831)2.38766618
110pinocytosis (GO:0006907)2.38742986
111regulation of interleukin-13 production (GO:0032656)2.38458895
112antigen processing and presentation of endogenous antigen (GO:0019883)2.38400565
113cranial nerve development (GO:0021545)2.38362119
114iron ion import (GO:0097286)2.37768695
115regulation of gamma-delta T cell differentiation (GO:0045586)2.37092009
116negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.36775594
117neutrophil activation involved in immune response (GO:0002283)2.36756811
118positive regulation of leukocyte degranulation (GO:0043302)2.36255026
119regulation of osteoblast proliferation (GO:0033688)2.35912236
120regulation of transforming growth factor beta2 production (GO:0032909)2.35583337
121response to muramyl dipeptide (GO:0032495)2.35518372
122negative regulation of myoblast differentiation (GO:0045662)2.35434481
123antigen processing and presentation via MHC class Ib (GO:0002475)2.35259841
124pre-miRNA processing (GO:0031054)2.35221472
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34994977
126cellular response to epidermal growth factor stimulus (GO:0071364)2.34126651
127regulation of nucleobase-containing compound transport (GO:0032239)2.33797017
128long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.33527714
129regulation of leukocyte degranulation (GO:0043300)2.33058246
130neuron fate determination (GO:0048664)2.32771883
131desmosome organization (GO:0002934)2.31913213
132cell-substrate junction assembly (GO:0007044)2.31615978
133cortical actin cytoskeleton organization (GO:0030866)2.31050869
1343-UTR-mediated mRNA stabilization (GO:0070935)2.30593691
135glycosylceramide metabolic process (GO:0006677)2.30537609
136skin morphogenesis (GO:0043589)2.29640733
137lipid translocation (GO:0034204)2.29355445
138phospholipid translocation (GO:0045332)2.29355445
139cell-substrate adherens junction assembly (GO:0007045)2.28968811
140focal adhesion assembly (GO:0048041)2.28968811
141glial cell development (GO:0021782)2.28959471
142detection of bacterium (GO:0016045)2.28302740
143detection of external biotic stimulus (GO:0098581)2.27161747
144long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.27055291
145negative regulation of JUN kinase activity (GO:0043508)2.26960569
146mRNA transcription (GO:0009299)2.26813628
147regulation of feeding behavior (GO:0060259)2.26637646
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26512062
149tissue regeneration (GO:0042246)2.26356261
150negative regulation of anoikis (GO:2000811)2.25814446
151nerve growth factor signaling pathway (GO:0038180)2.25578213
152embryonic eye morphogenesis (GO:0048048)2.25348015
153myelination in peripheral nervous system (GO:0022011)2.25219737
154peripheral nervous system axon ensheathment (GO:0032292)2.25219737
155adherens junction assembly (GO:0034333)2.25094592
156cell adhesion mediated by integrin (GO:0033627)2.25076745
157amyloid precursor protein catabolic process (GO:0042987)2.24331351
158positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.24209624
159mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.24209624
160leukocyte aggregation (GO:0070486)2.24208100
161regulation of oligodendrocyte differentiation (GO:0048713)2.23955504
162negative regulation of axonogenesis (GO:0050771)2.23751143
163enteric nervous system development (GO:0048484)2.23695879
164membrane protein ectodomain proteolysis (GO:0006509)2.23635691
165regulation of interferon-beta biosynthetic process (GO:0045357)2.22800862
166peripheral nervous system development (GO:0007422)2.22334078
167negative regulation of chemokine production (GO:0032682)2.22273015
168programmed necrotic cell death (GO:0097300)2.21914677
169regulation of necroptotic process (GO:0060544)2.21825274
170lung lobe morphogenesis (GO:0060463)2.21450078
171glial cell differentiation (GO:0010001)2.20687909
172histone lysine demethylation (GO:0070076)2.20618037
173cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.20543172
174lateral sprouting from an epithelium (GO:0060601)2.20063895
175response to interleukin-15 (GO:0070672)2.19943678
176regulation of cytokine production involved in inflammatory response (GO:1900015)2.19645116
177cellular extravasation (GO:0045123)2.19438166
178positive regulation of osteoblast proliferation (GO:0033690)2.18863713
179cytoskeletal anchoring at plasma membrane (GO:0007016)2.18697957
180production of molecular mediator involved in inflammatory response (GO:0002532)2.17534262
181hemidesmosome assembly (GO:0031581)2.17422506
182* protein palmitoylation (GO:0018345)2.17243230
183necrotic cell death (GO:0070265)2.17165844
184response to epidermal growth factor (GO:0070849)2.17043176
185bundle of His cell to Purkinje myocyte communication (GO:0086069)2.16938548
186regulation of T cell migration (GO:2000404)2.16880640
187regulation of interleukin-5 production (GO:0032674)2.16863571
188cyclic nucleotide catabolic process (GO:0009214)2.15794207
189negative regulation of protein localization to plasma membrane (GO:1903077)2.15630636
190activated T cell proliferation (GO:0050798)2.15606664
191negative regulation of toll-like receptor signaling pathway (GO:0034122)2.14338101
192macrophage activation involved in immune response (GO:0002281)2.14159810
193peptidyl-threonine modification (GO:0018210)2.14138949
194dosage compensation (GO:0007549)2.14119411
195negative regulation of interleukin-12 production (GO:0032695)2.11905246
196response to host defenses (GO:0052200)2.11795524
197axon ensheathment in central nervous system (GO:0032291)10.2417286
198central nervous system myelination (GO:0022010)10.2417286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.55904446
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.92428281
3E2F7_22180533_ChIP-Seq_HELA_Human3.18537856
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.11141412
5GBX2_23144817_ChIP-Seq_PC3_Human3.01453912
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67338278
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61256384
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61190953
9TAF15_26573619_Chip-Seq_HEK293_Human2.51644570
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45779971
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.44201522
12MYC_22102868_ChIP-Seq_BL_Human2.36134087
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.35416126
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34758487
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31105007
16AR_21572438_ChIP-Seq_LNCaP_Human2.29289848
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28152479
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25330779
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14904116
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12820961
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11538610
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11531283
23AR_21909140_ChIP-Seq_LNCAP_Human2.11460780
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06755378
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03384349
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02642719
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01665527
28IGF1R_20145208_ChIP-Seq_DFB_Human1.97613865
29TCF7_22412390_ChIP-Seq_EML_Mouse1.96425115
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96385256
31* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.95431492
32GATA1_22025678_ChIP-Seq_K562_Human1.95315783
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.95147744
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93927106
35ER_23166858_ChIP-Seq_MCF-7_Human1.92934875
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92412570
37CLOCK_20551151_ChIP-Seq_293T_Human1.90669713
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.89005943
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87962042
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.86841157
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85814351
42* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83862706
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83418889
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82410950
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81772570
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.76301010
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.74243869
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73263050
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.72772093
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72419235
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72419235
52EZH2_22144423_ChIP-Seq_EOC_Human1.72408370
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.71380680
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70940244
55VDR_22108803_ChIP-Seq_LS180_Human1.69495140
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69401055
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68565167
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68153637
59FUS_26573619_Chip-Seq_HEK293_Human1.66263682
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65895724
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65895724
62P300_19829295_ChIP-Seq_ESCs_Human1.65294181
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64911702
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62594939
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61681528
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61499497
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.58557860
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57673923
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.57659955
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55779898
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.54268534
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53635641
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52477227
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50756389
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49508107
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48987346
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48297168
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.48130090
79MYB_26560356_Chip-Seq_TH2_Human1.47780585
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47613656
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.47353112
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.47277205
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46906479
84MYB_26560356_Chip-Seq_TH1_Human1.46509199
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.46149406
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44894398
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44222816
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43716072
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43347783
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40982400
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.40865649
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40562341
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40472435
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40075776
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.40001583
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.39636520
97VDR_24763502_ChIP-Seq_THP-1_Human1.39603679
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.39419041
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39261134
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38064312
101SCL_19346495_ChIP-Seq_HPC-7_Human1.37335613
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37261754
103SPI1_23547873_ChIP-Seq_NB4_Human1.36418208
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36180645
105EWS_26573619_Chip-Seq_HEK293_Human1.36075650
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34913000
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34613127
108MAF_26560356_Chip-Seq_TH1_Human1.33483884
109VDR_21846776_ChIP-Seq_THP-1_Human1.31752353
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31453042
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.31040967
112RNF2_27304074_Chip-Seq_NSC_Mouse1.30618468
113PU_27001747_Chip-Seq_BMDM_Mouse1.29973846
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29738075
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29499037
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29155913
117P300_18555785_Chip-Seq_ESCs_Mouse1.27990354
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27655728
119LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27411554
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.27074811
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27027890
122TP53_18474530_ChIP-ChIP_U2OS_Human1.26882743
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26786691
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26786691
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26786691
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26711530
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.26350272
128* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24025438
129TRIM28_21343339_ChIP-Seq_HEK293_Human1.23665132
130P53_22387025_ChIP-Seq_ESCs_Mouse1.23349464
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23134078
132SMAD4_21799915_ChIP-Seq_A2780_Human1.23094814
133RUNX_20019798_ChIP-Seq_JUKART_Human1.22551210
134CHD1_26751641_Chip-Seq_LNCaP_Human1.20572301
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20482514
136TAL1_26923725_Chip-Seq_HPCs_Mouse1.19829758
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.19294974
138PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19167340
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19021206
140* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18422917
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18161147
142ELK3_25401928_ChIP-Seq_HUVEC_Human1.17958792
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17958087
144STAT3_23295773_ChIP-Seq_U87_Human1.17847671
145* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17798707
146* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17798707
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17162630
148ESR2_21235772_ChIP-Seq_MCF-7_Human1.17011883
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16831529
150ESR1_21235772_ChIP-Seq_MCF-7_Human1.16286428
151* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16277002
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16181675
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15437221
154* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14572435
155KDM2B_26808549_Chip-Seq_DND41_Human1.14427222
156NFE2_27457419_Chip-Seq_LIVER_Mouse1.13914074
157TP53_16413492_ChIP-PET_HCT116_Human1.13786513
158* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12202988
159P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11810039
160* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11387867
161* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11365486
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09887640
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09778066
164KDM2B_26808549_Chip-Seq_JURKAT_Human1.08743934
165KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08644191
166RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08556813
167* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07962070
168RUNX1_27514584_Chip-Seq_MCF-7_Human1.07897846
169SOX2_18555785_Chip-Seq_ESCs_Mouse1.07795547
170ARNT_22903824_ChIP-Seq_MCF-7_Human1.07787787
171GATA6_25053715_ChIP-Seq_YYC3_Human1.07459773
172IRF1_19129219_ChIP-ChIP_H3396_Human1.07446151
173PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07330663
174NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06995541
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06956512
176KLF4_18555785_Chip-Seq_ESCs_Mouse1.06443138
177LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05312951
178NMYC_18555785_Chip-Seq_ESCs_Mouse1.04442949
179UTX_26944678_Chip-Seq_JUKART_Human1.02246112
180SPI1_23127762_ChIP-Seq_K562_Human1.02187175
181GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01524739
182GATA2_21666600_ChIP-Seq_HMVEC_Human1.01297321
183UBF1/2_26484160_Chip-Seq_HMECs_Human0.98755698
184* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97889200
185SALL1_21062744_ChIP-ChIP_HESCs_Human0.97042706
186BRD4_25478319_ChIP-Seq_HGPS_Human0.96880609
187VDR_24787735_ChIP-Seq_THP-1_Human0.95684141
188SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95101887
189RACK7_27058665_Chip-Seq_MCF-7_Human0.94582087
190IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91572214
191CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91378325
192ATF3_27146783_Chip-Seq_COLON_Human0.90320886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.79984987
2MP0010234_abnormal_vibrissa_follicle3.91345521
3MP0003950_abnormal_plasma_membrane3.86683829
4MP0003705_abnormal_hypodermis_morpholog3.55932639
5MP0010352_gastrointestinal_tract_polyps3.45811872
6MP0005171_absent_coat_pigmentation3.18167226
7MP0005409_darkened_coat_color3.14007508
8MP0003880_abnormal_central_pattern3.09861323
9MP0004742_abnormal_vestibular_system3.05339977
10MP0002877_abnormal_melanocyte_morpholog2.91785030
11MP0003136_yellow_coat_color2.86532450
12MP0008057_abnormal_DNA_replication2.76458636
13MP0003690_abnormal_glial_cell2.59119851
14MP0003300_gastrointestinal_ulcer2.45978603
15MP0004264_abnormal_extraembryonic_tissu2.43174036
16MP0003566_abnormal_cell_adhesion2.24984267
17MP0005076_abnormal_cell_differentiation2.23702954
18MP0003191_abnormal_cellular_cholesterol2.18129095
19MP0008260_abnormal_autophagy2.15952372
20MP0002166_altered_tumor_susceptibility2.13562464
21MP0004381_abnormal_hair_follicle2.05923987
22MP0001529_abnormal_vocalization1.99005783
23MP0002796_impaired_skin_barrier1.98726240
24MP0003763_abnormal_thymus_physiology1.95372390
25MP0001905_abnormal_dopamine_level1.93541333
26MP0001486_abnormal_startle_reflex1.92554691
27MP0003634_abnormal_glial_cell1.86665153
28MP0001188_hyperpigmentation1.85298803
29MP0004134_abnormal_chest_morphology1.81202633
30MP0004185_abnormal_adipocyte_glucose1.80459898
31MP0000383_abnormal_hair_follicle1.80422141
32MP0002272_abnormal_nervous_system1.78246655
33MP0004885_abnormal_endolymph1.75550731
34MP0003091_abnormal_cell_migration1.75296862
35MP0004947_skin_inflammation1.73875466
36MP0002396_abnormal_hematopoietic_system1.73551672
37MP0003828_pulmonary_edema1.72603330
38MP0002006_tumorigenesis1.70784027
39MP0003453_abnormal_keratinocyte_physiol1.70552168
40MP0003724_increased_susceptibility_to1.65554990
41MP0010678_abnormal_skin_adnexa1.60952111
42MP0001835_abnormal_antigen_presentation1.59978842
43MP0000778_abnormal_nervous_system1.58304293
44MP0005451_abnormal_body_composition1.57645653
45MP0001485_abnormal_pinna_reflex1.56765213
46MP0008438_abnormal_cutaneous_collagen1.56544253
47MP0001851_eye_inflammation1.55988112
48MP0004142_abnormal_muscle_tone1.53226909
49MP0006082_CNS_inflammation1.49308127
50MP0005623_abnormal_meninges_morphology1.44639108
51MP0003436_decreased_susceptibility_to1.44391009
52MP0004808_abnormal_hematopoietic_stem1.39712855
53MP0003303_peritoneal_inflammation1.39466876
54MP0003941_abnormal_skin_development1.38259746
55MP0001849_ear_inflammation1.37437139
56MP0004270_analgesia1.36713320
57MP0002064_seizures1.35711629
58MP0000858_altered_metastatic_potential1.35339937
59MP0010155_abnormal_intestine_physiology1.33963192
60MP0002102_abnormal_ear_morphology1.31918919
61MP0002933_joint_inflammation1.31647068
62MP0005645_abnormal_hypothalamus_physiol1.31403357
63MP0000537_abnormal_urethra_morphology1.30594058
64MP0004957_abnormal_blastocyst_morpholog1.27016482
65MP0005503_abnormal_tendon_morphology1.26416170
66MP0000566_synostosis1.26411475
67MP0005410_abnormal_fertilization1.25225051
68MP0002060_abnormal_skin_morphology1.23606856
69MP0009250_abnormal_appendicular_skeleto1.22936421
70MP0000465_gastrointestinal_hemorrhage1.22846803
71MP0002998_abnormal_bone_remodeling1.22659483
72MP0003448_altered_tumor_morphology1.21572343
73MP0005275_abnormal_skin_tensile1.21347871
74MP0005671_abnormal_response_to1.19358975
75MP0010307_abnormal_tumor_latency1.18373694
76MP0003632_abnormal_nervous_system1.17434845
77MP0005501_abnormal_skin_physiology1.17176224
78MP0001216_abnormal_epidermal_layer1.17069495
79MP0001963_abnormal_hearing_physiology1.16855388
80MP0002086_abnormal_extraembryonic_tissu1.15817941
81MP0002229_neurodegeneration1.14541993
82MP0005423_abnormal_somatic_nervous1.14509654
83MP0003938_abnormal_ear_development1.14199292
84MP0000490_abnormal_crypts_of1.12862326
85MP0003937_abnormal_limbs/digits/tail_de1.12322125
86MP0002938_white_spotting1.08940139
87MP0001730_embryonic_growth_arrest1.07547192
88MP0003329_amyloid_beta_deposits1.05166268
89MP0001177_atelectasis1.04014383
90MP0002098_abnormal_vibrissa_morphology1.03821697
91MP0004272_abnormal_basement_membrane1.03626705
92MP0003221_abnormal_cardiomyocyte_apopto1.03174146
93MP0000377_abnormal_hair_follicle1.02719925
94MP0003631_nervous_system_phenotype1.01940623
95MP0005464_abnormal_platelet_physiology1.01672784
96MP0001800_abnormal_humoral_immune1.01376271
97MP0002452_abnormal_antigen_presenting1.01125713
98MP0004782_abnormal_surfactant_physiolog1.00945282
99MP0001346_abnormal_lacrimal_gland1.00135036
100MP0000462_abnormal_digestive_system0.99700499
101MP0002420_abnormal_adaptive_immunity0.99473201
102MP0001348_abnormal_lacrimal_gland0.99092856
103MP0008569_lethality_at_weaning0.98899151
104MP0000372_irregular_coat_pigmentation0.98702630
105MP0005023_abnormal_wound_healing0.98562231
106MP0002398_abnormal_bone_marrow0.98524347
107MP0003633_abnormal_nervous_system0.98377521
108MP0001819_abnormal_immune_cell0.98144259
109MP0002067_abnormal_sensory_capabilities0.97850635
110MP0005621_abnormal_cell_physiology0.97636964
111MP0009745_abnormal_behavioral_response0.97410044
112MP0000015_abnormal_ear_pigmentation0.96824657
113MP0000627_abnormal_mammary_gland0.96769059
114MP0000703_abnormal_thymus_morphology0.95833982
115MP0005058_abnormal_lysosome_morphology0.95802913
116MP0001853_heart_inflammation0.95421513
117MP0000026_abnormal_inner_ear0.95240155
118MP0001915_intracranial_hemorrhage0.94912628
119MP0000762_abnormal_tongue_morphology0.94906302
120MP0002572_abnormal_emotion/affect_behav0.94873249
121MP0001299_abnormal_eye_distance/0.94843590
122MP0003984_embryonic_growth_retardation0.93969621
123MP0002405_respiratory_system_inflammati0.93876336
124MP0003183_abnormal_peptide_metabolism0.93844947
125MP0000350_abnormal_cell_proliferation0.93282456
126MP0000685_abnormal_immune_system0.92567796
127MP0005000_abnormal_immune_tolerance0.92319127
128MP0002148_abnormal_hypersensitivity_rea0.91430843
129MP0002088_abnormal_embryonic_growth/wei0.90918740
130MP0005380_embryogenesis_phenotype0.90297193
131MP0001672_abnormal_embryogenesis/_devel0.90297193
132MP0001533_abnormal_skeleton_physiology0.90234620
133MP0005551_abnormal_eye_electrophysiolog0.90105881
134MP0005408_hypopigmentation0.89132608
135MP0005310_abnormal_salivary_gland0.88968449
136MP0001970_abnormal_pain_threshold0.88036153
137MP0005025_abnormal_response_to0.87933485
138MP0005388_respiratory_system_phenotype0.87921129
139MP0002133_abnormal_respiratory_system0.87921129
140MP0002295_abnormal_pulmonary_circulatio0.87916947
141MP0000647_abnormal_sebaceous_gland0.86644859
142MP0002723_abnormal_immune_serum0.86298060
143MP0001873_stomach_inflammation0.86136593
144MP0005646_abnormal_pituitary_gland0.85656325
145MP0002882_abnormal_neuron_morphology0.85570008
146MP0009046_muscle_twitch0.84792648
147MP0001440_abnormal_grooming_behavior0.84507179
148MP0002752_abnormal_somatic_nervous0.84402458
149MP0002009_preneoplasia0.84244858
150MP0000631_abnormal_neuroendocrine_gland0.83927755
151MP0001879_abnormal_lymphatic_vessel0.83508055
152MP0004883_abnormal_blood_vessel0.83203876
153MP0002722_abnormal_immune_system0.83041394
154MP0002419_abnormal_innate_immunity0.82988318
155MP0006072_abnormal_retinal_apoptosis0.82892204
156MP0000955_abnormal_spinal_cord0.82330853
157MP0000477_abnormal_intestine_morphology0.82323148
158MP0000716_abnormal_immune_system0.82188794
159MP0000767_abnormal_smooth_muscle0.81649708
160MP0005195_abnormal_posterior_eye0.80808677
161MP0006054_spinal_hemorrhage0.80415355
162MP0003866_abnormal_defecation0.79876622
163MP0001790_abnormal_immune_system0.79683814
164MP0005387_immune_system_phenotype0.79683814
165MP0001958_emphysema0.79524500
166MP0003635_abnormal_synaptic_transmissio0.79350131
167MP0001501_abnormal_sleep_pattern0.78492409
168MP0006292_abnormal_olfactory_placode0.75629984
169MP0001661_extended_life_span0.75454126
170MP0002734_abnormal_mechanical_nocicepti0.75244990
171MP0008004_abnormal_stomach_pH0.74323594
172MP0005164_abnormal_response_to0.74088250
173MP0009384_cardiac_valve_regurgitation0.73175024
174MP0009333_abnormal_splenocyte_physiolog0.72478935
175MP0001340_abnormal_eyelid_morphology0.72153511
176MP0001986_abnormal_taste_sensitivity0.72152776
177MP0005075_abnormal_melanosome_morpholog0.72128865
178MP0002277_abnormal_respiratory_mucosa0.70310128
179MP0002066_abnormal_motor_capabilities/c0.69158635
180MP0005253_abnormal_eye_physiology0.68169348

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.57569880
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.57569880
3Neurofibrillary tangles (HP:0002185)4.81775118
4Parakeratosis (HP:0001036)4.26417999
5Peripheral hypomyelination (HP:0007182)3.99266579
6Eczematoid dermatitis (HP:0000976)3.71543084
7Onion bulb formation (HP:0003383)3.61637391
8Abnormality of the corticospinal tract (HP:0002492)3.51416501
9Segmental peripheral demyelination/remyelination (HP:0003481)3.37921467
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.36010617
11Spinal cord lesions (HP:0100561)3.25333334
12Syringomyelia (HP:0003396)3.25333334
13White forelock (HP:0002211)3.09502316
14Patchy hypopigmentation of hair (HP:0011365)3.04627578
15Asymmetry of the thorax (HP:0001555)3.04447731
16Absent septum pellucidum (HP:0001331)3.03271700
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.02898846
18Osteolytic defects of the hand bones (HP:0009699)3.02898846
19Subacute progressive viral hepatitis (HP:0006572)2.98252379
20Cerebral inclusion bodies (HP:0100314)2.96317506
21Abnormal auditory evoked potentials (HP:0006958)2.94792989
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.93360574
23Retinal dysplasia (HP:0007973)2.90795400
24Curly hair (HP:0002212)2.87323460
25Abnormality of the septum pellucidum (HP:0007375)2.75261168
26Ankyloglossia (HP:0010296)2.74907044
27Sensory axonal neuropathy (HP:0003390)2.73920853
28Alacrima (HP:0000522)2.70471642
29Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68603183
30Anteriorly placed anus (HP:0001545)2.68552638
31Recurrent bacterial skin infections (HP:0005406)2.65416004
32Abnormality of oral frenula (HP:0000190)2.58504676
33Recurrent abscess formation (HP:0002722)2.57277783
34Flat acetabular roof (HP:0003180)2.54608597
35Stomatitis (HP:0010280)2.53547416
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.53130583
37Septo-optic dysplasia (HP:0100842)2.52424507
38Insidious onset (HP:0003587)2.52262115
39Termporal pattern (HP:0011008)2.52262115
40Morphological abnormality of the inner ear (HP:0011390)2.51418069
41Hypoplasia of the iris (HP:0007676)2.51023170
42Clumsiness (HP:0002312)2.48058319
43Supranuclear gaze palsy (HP:0000605)2.41472710
44Conical tooth (HP:0000698)2.37272749
45Stridor (HP:0010307)2.36837322
46Decreased lacrimation (HP:0000633)2.36553667
47Slow saccadic eye movements (HP:0000514)2.36157315
48Absent frontal sinuses (HP:0002688)2.35969689
49Scanning speech (HP:0002168)2.34450880
50Premature skin wrinkling (HP:0100678)2.32652673
51Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.32306055
52Spastic gait (HP:0002064)2.31979469
53Hepatosplenomegaly (HP:0001433)2.29923101
54Papillary thyroid carcinoma (HP:0002895)2.29739632
55Autoamputation (HP:0001218)2.26049286
56Cupped ear (HP:0000378)2.24808087
57Transitional cell carcinoma of the bladder (HP:0006740)2.23684589
58Micronodular cirrhosis (HP:0001413)2.20324853
59Gingivitis (HP:0000230)2.18687277
60Congenital sensorineural hearing impairment (HP:0008527)2.18320521
61Deep philtrum (HP:0002002)2.18086982
62Malignant gastrointestinal tract tumors (HP:0006749)2.16894117
63Gastrointestinal carcinoma (HP:0002672)2.16894117
64Submucous cleft hard palate (HP:0000176)2.16271438
65Prolonged neonatal jaundice (HP:0006579)2.16031814
66Dysmetria (HP:0001310)2.15831600
67Hypoplastic pelvis (HP:0008839)2.15454174
68Inflammation of the large intestine (HP:0002037)2.13073176
69Adrenal hypoplasia (HP:0000835)2.11077119
70Metabolic alkalosis (HP:0200114)2.10939441
71Cellulitis (HP:0100658)2.10459562
72Gastrointestinal inflammation (HP:0004386)2.09585172
73Split foot (HP:0001839)2.09530404
74Bladder carcinoma (HP:0002862)2.09336360
75Bladder neoplasm (HP:0009725)2.09336360
76Congenital ichthyosiform erythroderma (HP:0007431)2.09258811
77Viral hepatitis (HP:0006562)2.09020441
78Right ventricular cardiomyopathy (HP:0011663)2.08737322
79Ankle clonus (HP:0011448)2.07423809
80Spontaneous hematomas (HP:0007420)2.06557802
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.05557056
82Chronic diarrhea (HP:0002028)2.05271352
83Hypophosphatemic rickets (HP:0004912)2.04715915
84Coarse hair (HP:0002208)2.04533515
85Chin dimple (HP:0010751)2.04509092
86Abnormality of macrophages (HP:0004311)2.03253714
87Acute myeloid leukemia (HP:0004808)2.02987649
88Recurrent viral infections (HP:0004429)2.01313056
89Premature rupture of membranes (HP:0001788)2.00997535
90Colitis (HP:0002583)1.99345942
91Uterine leiomyosarcoma (HP:0002891)1.99300449
92Leiomyosarcoma (HP:0100243)1.99300449
93Relative macrocephaly (HP:0004482)1.98847620
94Periodontitis (HP:0000704)1.98818187
95Esophageal atresia (HP:0002032)1.98509779
96Cerebral hypomyelination (HP:0006808)1.97879954
97Thickened helices (HP:0000391)1.96153734
98Esophageal varix (HP:0002040)1.94729758
99Broad face (HP:0000283)1.93259748
100Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93137586
101Vascular tortuosity (HP:0004948)1.92571668
102T lymphocytopenia (HP:0005403)1.92433035
103Dilatation of the ascending aorta (HP:0005111)1.91740963
104Aplasia involving bones of the extremities (HP:0009825)1.90917046
105Aplasia involving bones of the upper limbs (HP:0009823)1.90917046
106Aplasia of the phalanges of the hand (HP:0009802)1.90917046
107Mixed hearing impairment (HP:0000410)1.90698652
108Axonal loss (HP:0003447)1.90407707
109Abnormality of the fingertips (HP:0001211)1.88553178
110Long nose (HP:0003189)1.86953735
111Germ cell neoplasia (HP:0100728)1.85499069
112Arterial tortuosity (HP:0005116)1.85361218
113Duplicated collecting system (HP:0000081)1.85337425
114Decreased motor nerve conduction velocity (HP:0003431)1.85091341
115Partial duplication of thumb phalanx (HP:0009944)1.85013499
116Corneal dystrophy (HP:0001131)1.82793170
117Myelomeningocele (HP:0002475)1.82435362
118Infantile muscular hypotonia (HP:0008947)1.80881627
119Widely spaced teeth (HP:0000687)1.80660026
120Abnormality of the middle phalanges of the toes (HP:0010183)1.79782855
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79583867
122Abnormality of T cell number (HP:0011839)1.78997885
123Mitral valve prolapse (HP:0001634)1.78644481
124Myocardial infarction (HP:0001658)1.77590803
125Hypomagnesemia (HP:0002917)1.77145796
126Xerostomia (HP:0000217)1.74096313
127Osteomyelitis (HP:0002754)1.73562216
128Thin bony cortex (HP:0002753)1.73476134
129Abnormality of the renal collecting system (HP:0004742)1.71391095
130Aortic dissection (HP:0002647)1.69956678
131Abnormal foot bone ossification (HP:0010675)1.69241439
132Hematochezia (HP:0002573)1.68734043
133Abnormality of incisor morphology (HP:0011063)1.68680685
134Protrusio acetabuli (HP:0003179)1.68313363
135Selective tooth agenesis (HP:0001592)1.68163994
136Humeroradial synostosis (HP:0003041)1.68110166
137Synostosis involving the elbow (HP:0003938)1.68110166
138Abnormality of the 2nd finger (HP:0004100)1.67141168
139Overgrowth (HP:0001548)1.66853165
140Renal cell carcinoma (HP:0005584)1.66767159
141Metaphyseal dysplasia (HP:0100255)1.65961747
142Intention tremor (HP:0002080)1.65957079
143Broad-based gait (HP:0002136)1.65352642
144Gowers sign (HP:0003391)1.64107378
145Pulmonary artery stenosis (HP:0004415)1.64051851
146Aortic aneurysm (HP:0004942)1.63852054
147Abnormality of the frontal sinuses (HP:0002687)1.63380108
148Abnormal hair whorl (HP:0010721)1.62873487
149Abnormal platelet volume (HP:0011876)1.62803168
150Abnormality of the columella (HP:0009929)1.62026868
151Hyperacusis (HP:0010780)1.62004015
152Recurrent skin infections (HP:0001581)1.61391688
153Arnold-Chiari malformation (HP:0002308)1.61227041
154Partial duplication of the phalanx of hand (HP:0009999)1.61104217
155Gastrointestinal atresia (HP:0002589)1.60524571
156Nephroblastoma (Wilms tumor) (HP:0002667)1.60403824
157Pterygium (HP:0001059)1.60296693
158Interstitial pulmonary disease (HP:0006530)1.60279682
159Abnormality of the lumbar spine (HP:0100712)1.60209493
160Aplasia/Hypoplasia of the lens (HP:0008063)1.60128140
161Abnormality of cochlea (HP:0000375)1.60083168
162CNS hypomyelination (HP:0003429)1.59070506
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.58792329
164Absent/shortened dynein arms (HP:0200106)1.58792329
165Abnormality of the gastric mucosa (HP:0004295)1.58725923
166Dysmetric saccades (HP:0000641)1.57478688
167Vaginal atresia (HP:0000148)1.56462234
168Increased circulating renin level (HP:0000848)1.56064598
169Mediastinal lymphadenopathy (HP:0100721)1.55853944
170Cerebral aneurysm (HP:0004944)1.55842377
171Skull defect (HP:0001362)1.55625595
172Abnormality of the thoracic spine (HP:0100711)1.55211981
173Genital tract atresia (HP:0001827)1.55018286
174Short clavicles (HP:0000894)1.54933738
175Vertebral arch anomaly (HP:0008438)1.54264229
176Deviation of the thumb (HP:0009603)1.53384399
177Increased mean platelet volume (HP:0011877)1.53345366
178Large earlobe (HP:0009748)1.52939370
179Autoimmune hemolytic anemia (HP:0001890)1.52612619
180Embryonal renal neoplasm (HP:0011794)1.51922370
181Recurrent gram-negative bacterial infections (HP:0005420)1.50274766
182Thyroid carcinoma (HP:0002890)1.50208900
183Thickened calvaria (HP:0002684)1.49997621
184Abnormality of the distal phalanges of the toes (HP:0010182)1.49366748
185Missing ribs (HP:0000921)1.48835727
186Fatigue (HP:0012378)1.48754994
187Aneurysm (HP:0002617)1.48527562
188Cystic hygroma (HP:0000476)1.48229371
189Hemangiomatosis (HP:0007461)1.47862056
190Dislocated radial head (HP:0003083)1.46157012
191Short nail (HP:0001799)1.45323316
192Recurrent fungal infections (HP:0002841)1.45232711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.07500186
2EPHB13.41485251
3SCYL23.16724945
4MAPKAPK53.09384633
5OXSR13.02657055
6CASK2.62723355
7MAP3K102.62445762
8CDK122.61294848
9TRIB32.58718630
10PBK2.52609485
11LATS12.47053860
12PKN12.41241905
13EEF2K2.12972177
14MST1R2.03610788
15CDK61.99982964
16SMG11.99843047
17PDGFRA1.90102812
18FGFR41.89475017
19CLK11.88869516
20BCR1.88711607
21MKNK11.83908413
22MST41.82712910
23TXK1.73077183
24WNK41.67605408
25PNCK1.65769275
26NEK61.65084015
27JAK11.63692635
28BRD41.63552671
29LATS21.61445510
30TESK21.60303996
31MKNK21.59377065
32WNK11.58872776
33STK241.54570581
34FGFR31.53513753
35FGFR21.53404344
36MAP3K21.51486381
37KSR21.50205570
38ADRBK21.46917058
39LIMK11.45739988
40UHMK11.44090600
41BMPR1B1.43929295
42MET1.43466144
43PKN21.42719071
44MAP3K131.38590389
45RIPK11.33419513
46TYK21.31609714
47MUSK1.31269984
48CAMK2B1.31194344
49TNIK1.29796118
50EPHA21.29533308
51BLK1.29236947
52NEK91.28218897
53CSNK1A1L1.27914021
54TRPM71.27840999
55FGR1.26684488
56RPS6KB21.25030896
57ICK1.21955906
58PAK41.20668411
59PTK61.18383726
60MAPK151.16880887
61IRAK21.16768965
62MAP2K31.15771034
63INSRR1.15562441
64CSNK1G31.15193134
65MELK1.15057898
66SIK11.12853457
67ROCK21.11083099
68TTN1.09324299
69PRPF4B1.08179128
70GRK71.07814684
71STK31.03797771
72ZAP701.03790738
73EIF2AK31.02748770
74CAMK2D1.02210987
75SGK2231.01651266
76SGK4941.01651266
77CSNK1G11.01548513
78SGK31.01053120
79RPS6KA50.95563324
80RET0.94976102
81PRKCQ0.94772490
82JAK30.94337304
83STK38L0.93967330
84NLK0.93840954
85MAP3K10.93132777
86RPS6KA40.92580256
87STK160.92568394
88TIE10.92411121
89YES10.90991130
90PRKCE0.90162469
91ITK0.89393491
92MAP3K60.89149966
93KSR10.88964380
94FES0.88452843
95PAK30.87863253
96BTK0.84548531
97BMPR20.84465797
98CSNK1G20.84050714
99IRAK30.82015164
100CAMK1G0.80135007
101PASK0.78896837
102DYRK20.76660887
103MARK20.75566382
104FGFR10.75487634
105LCK0.74741347
106CDK190.73996184
107CSK0.73185134
108TAF10.72981188
109CAMK2A0.70169918
110IRAK40.69958735
111STK100.69509559
112IRAK10.68735634
113CDK40.68356310
114JAK20.68092127
115PRKD10.66883013
116NUAK10.66373974
117MAP3K140.65721264
118MAP3K80.65283459
119MTOR0.64142237
120NTRK10.63632033
121MAP3K30.63519761
122ALK0.63354564
123HIPK20.62948214
124CAMK2G0.62113155
125MAP3K90.61291979
126GRK10.60832372
127PIK3CA0.60691606
128MAP2K20.60336711
129CDK30.56923271
130PRKG10.56603301
131TEC0.56594128
132SIK30.54382511
133FYN0.54237514
134PRKCH0.54138842
135ERN10.53634826
136PRKD20.53502618
137CAMK1D0.52880273
138GRK60.51722063
139MAPK70.51376513
140INSR0.51052876
141MAPK130.50109985
142SGK20.49933061
143PDGFRB0.49870463
144EPHA30.49751360
145KIT0.48301292
146CSF1R0.47737281
147VRK10.46997802
148ACVR1B0.46702755
149MAP3K120.45389639
150PLK20.44915733
151RPS6KL10.44164787
152RPS6KC10.44164787
153GSK3A0.43998145
154CDK70.43865407
155HCK0.43383749
156LRRK20.42788085
157RPS6KB10.42667210
158BRSK20.42596009
159LYN0.41093004
160DYRK1A0.40097539
161CDK50.37877311
162NTRK20.35761931
163CSNK1A10.34815132
164IKBKE0.33826799
165CSNK1D0.33452272
166MAP4K10.31719660
167RIPK40.31154734
168PAK20.30741881
169PDPK10.29623451
170AKT30.29344439

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.11042935
2Steroid biosynthesis_Homo sapiens_hsa001003.28423079
3Ether lipid metabolism_Homo sapiens_hsa005652.88917729
4Fatty acid elongation_Homo sapiens_hsa000622.72637540
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72307524
6Protein export_Homo sapiens_hsa030602.31290161
7Sphingolipid metabolism_Homo sapiens_hsa006002.09750487
8Thyroid cancer_Homo sapiens_hsa052162.06993789
9Chronic myeloid leukemia_Homo sapiens_hsa052202.06675609
10Non-small cell lung cancer_Homo sapiens_hsa052231.91126616
11Pancreatic cancer_Homo sapiens_hsa052121.80559172
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.80463696
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78824754
14Endometrial cancer_Homo sapiens_hsa052131.78512854
15Acute myeloid leukemia_Homo sapiens_hsa052211.77187673
16Rheumatoid arthritis_Homo sapiens_hsa053231.56223071
17Graft-versus-host disease_Homo sapiens_hsa053321.50924285
18Autoimmune thyroid disease_Homo sapiens_hsa053201.50808578
19Adherens junction_Homo sapiens_hsa045201.48771544
20Axon guidance_Homo sapiens_hsa043601.47692577
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46306152
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45885752
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41213748
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39090372
25Linoleic acid metabolism_Homo sapiens_hsa005911.37998569
26Proteoglycans in cancer_Homo sapiens_hsa052051.37713300
27Colorectal cancer_Homo sapiens_hsa052101.35175039
28Hepatitis B_Homo sapiens_hsa051611.34887981
29Small cell lung cancer_Homo sapiens_hsa052221.34486531
30Vitamin B6 metabolism_Homo sapiens_hsa007501.30402138
31Bladder cancer_Homo sapiens_hsa052191.29242215
32MicroRNAs in cancer_Homo sapiens_hsa052061.28511717
33Serotonergic synapse_Homo sapiens_hsa047261.25510205
34Measles_Homo sapiens_hsa051621.25490605
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22965553
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22645420
37Allograft rejection_Homo sapiens_hsa053301.21556687
38VEGF signaling pathway_Homo sapiens_hsa043701.21192037
39Malaria_Homo sapiens_hsa051441.20609646
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.18901834
41Prolactin signaling pathway_Homo sapiens_hsa049171.17925840
42Toxoplasmosis_Homo sapiens_hsa051451.17316524
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17031994
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15797918
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14256702
46Glutamatergic synapse_Homo sapiens_hsa047241.12767387
47Renal cell carcinoma_Homo sapiens_hsa052111.12726731
48Glioma_Homo sapiens_hsa052141.12713050
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12580318
50Viral carcinogenesis_Homo sapiens_hsa052031.11849697
51Inositol phosphate metabolism_Homo sapiens_hsa005621.11616424
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11242207
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11213470
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11056509
55Hepatitis C_Homo sapiens_hsa051601.10395710
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.10149063
57Apoptosis_Homo sapiens_hsa042101.09230906
58Influenza A_Homo sapiens_hsa051641.07599048
59Morphine addiction_Homo sapiens_hsa050321.05551613
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04497517
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03936975
62Sphingolipid signaling pathway_Homo sapiens_hsa040711.03494136
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03094978
64Tuberculosis_Homo sapiens_hsa051521.02705777
65TNF signaling pathway_Homo sapiens_hsa046681.02119592
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01553697
67Long-term depression_Homo sapiens_hsa047301.00337655
68Shigellosis_Homo sapiens_hsa051311.00268731
69Amoebiasis_Homo sapiens_hsa051461.00194971
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99885014
71Arachidonic acid metabolism_Homo sapiens_hsa005900.99270853
72T cell receptor signaling pathway_Homo sapiens_hsa046600.97203084
73Hematopoietic cell lineage_Homo sapiens_hsa046400.96585342
74GABAergic synapse_Homo sapiens_hsa047270.96069290
75Asthma_Homo sapiens_hsa053100.95966381
76Legionellosis_Homo sapiens_hsa051340.95935810
77Ras signaling pathway_Homo sapiens_hsa040140.94687347
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.94348768
79FoxO signaling pathway_Homo sapiens_hsa040680.94326180
80Sulfur metabolism_Homo sapiens_hsa009200.93995270
81Histidine metabolism_Homo sapiens_hsa003400.93653312
82Primary immunodeficiency_Homo sapiens_hsa053400.93404544
83mTOR signaling pathway_Homo sapiens_hsa041500.92612305
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91391765
85GnRH signaling pathway_Homo sapiens_hsa049120.90260579
86Vibrio cholerae infection_Homo sapiens_hsa051100.89668359
87Cocaine addiction_Homo sapiens_hsa050300.89375711
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87702294
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86686853
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.84766647
91Estrogen signaling pathway_Homo sapiens_hsa049150.84675106
92Phagosome_Homo sapiens_hsa041450.84388431
93Ovarian steroidogenesis_Homo sapiens_hsa049130.83984786
94Herpes simplex infection_Homo sapiens_hsa051680.83299581
95ECM-receptor interaction_Homo sapiens_hsa045120.81160830
96Chemokine signaling pathway_Homo sapiens_hsa040620.80722619
97HTLV-I infection_Homo sapiens_hsa051660.79192959
98Lysosome_Homo sapiens_hsa041420.79045537
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78486173
100Salmonella infection_Homo sapiens_hsa051320.75792675
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.75573973
102Pathways in cancer_Homo sapiens_hsa052000.74938982
103HIF-1 signaling pathway_Homo sapiens_hsa040660.74314416
104Nicotine addiction_Homo sapiens_hsa050330.74126109
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.73864078
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73758821
107Insulin signaling pathway_Homo sapiens_hsa049100.72730942
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.72619535
109African trypanosomiasis_Homo sapiens_hsa051430.72532808
110Insulin resistance_Homo sapiens_hsa049310.71505979
111Long-term potentiation_Homo sapiens_hsa047200.69849962
112Notch signaling pathway_Homo sapiens_hsa043300.69766497
113Renin-angiotensin system_Homo sapiens_hsa046140.68224947
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66849215
115Mineral absorption_Homo sapiens_hsa049780.66735077
116Phototransduction_Homo sapiens_hsa047440.66371133
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64874041
118Antigen processing and presentation_Homo sapiens_hsa046120.64518248
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64043955
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63020070
121Viral myocarditis_Homo sapiens_hsa054160.62671741
122Tight junction_Homo sapiens_hsa045300.62523221
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.62173155
124Choline metabolism in cancer_Homo sapiens_hsa052310.61581426
125Endocytosis_Homo sapiens_hsa041440.60214072
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59914910
127Collecting duct acid secretion_Homo sapiens_hsa049660.59710703
128Circadian entrainment_Homo sapiens_hsa047130.59041444
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58283199
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57664113
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57132092
132Taste transduction_Homo sapiens_hsa047420.56844620
133Melanoma_Homo sapiens_hsa052180.56746198
134Rap1 signaling pathway_Homo sapiens_hsa040150.56420124
135Other glycan degradation_Homo sapiens_hsa005110.56272393
136Cell cycle_Homo sapiens_hsa041100.56090885
137Pertussis_Homo sapiens_hsa051330.55865710
138Cholinergic synapse_Homo sapiens_hsa047250.54628317
139mRNA surveillance pathway_Homo sapiens_hsa030150.54461613
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.54288887
141Osteoclast differentiation_Homo sapiens_hsa043800.54245547
142Dorso-ventral axis formation_Homo sapiens_hsa043200.54075776
143TGF-beta signaling pathway_Homo sapiens_hsa043500.53619874
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53189059
145MAPK signaling pathway_Homo sapiens_hsa040100.53029738
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.52293566
147Gastric acid secretion_Homo sapiens_hsa049710.51719648
148Non-homologous end-joining_Homo sapiens_hsa034500.51384699
149Salivary secretion_Homo sapiens_hsa049700.50965910
150Prostate cancer_Homo sapiens_hsa052150.50628118
151Leishmaniasis_Homo sapiens_hsa051400.50199452
152Platelet activation_Homo sapiens_hsa046110.50003416
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49947797
154Pancreatic secretion_Homo sapiens_hsa049720.48872229
155Type I diabetes mellitus_Homo sapiens_hsa049400.48853097
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48051274
157Dopaminergic synapse_Homo sapiens_hsa047280.47243690
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47156640
159Renin secretion_Homo sapiens_hsa049240.46810667
160ErbB signaling pathway_Homo sapiens_hsa040120.45249517
161B cell receptor signaling pathway_Homo sapiens_hsa046620.43820354
162Wnt signaling pathway_Homo sapiens_hsa043100.42603597
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42599955
164Focal adhesion_Homo sapiens_hsa045100.42233738
165Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41906539
166Hedgehog signaling pathway_Homo sapiens_hsa043400.41191590

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