ZDHHC20P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.65087393
2acrosome reaction (GO:0007340)9.57499225
3chromosome condensation (GO:0030261)7.47443394
4protein targeting to Golgi (GO:0000042)7.42669829
5centriole replication (GO:0007099)7.33150785
6plasma membrane fusion (GO:0045026)7.24957268
7establishment of protein localization to Golgi (GO:0072600)7.24449854
8DNA packaging (GO:0006323)7.13755759
9sperm capacitation (GO:0048240)6.96518001
10spermatid development (GO:0007286)6.86816934
11microtubule depolymerization (GO:0007019)6.83953097
12retrograde transport, vesicle recycling within Golgi (GO:0000301)6.80373717
13protein polyglutamylation (GO:0018095)6.41354057
14rRNA methylation (GO:0031167)6.35636709
15microtubule polymerization or depolymerization (GO:0031109)6.21671283
16single strand break repair (GO:0000012)6.18036151
17centriole assembly (GO:0098534)6.10130670
18sperm-egg recognition (GO:0035036)6.08187574
19response to pheromone (GO:0019236)5.98051246
20multicellular organism reproduction (GO:0032504)5.78553165
21spermatogenesis (GO:0007283)5.78097764
22male gamete generation (GO:0048232)5.76505132
23calcium ion-dependent exocytosis (GO:0017156)5.47578053
24protein localization to Golgi apparatus (GO:0034067)5.45316683
25seminiferous tubule development (GO:0072520)5.35448808
26spermatid nucleus differentiation (GO:0007289)5.33958410
27binding of sperm to zona pellucida (GO:0007339)5.32044100
28gamete generation (GO:0007276)5.29233523
29rRNA modification (GO:0000154)5.24795684
30reproduction (GO:0000003)5.23402879
31axonemal dynein complex assembly (GO:0070286)5.20655290
32piRNA metabolic process (GO:0034587)5.13772856
33regulation of centriole replication (GO:0046599)5.06201262
34cell-cell recognition (GO:0009988)5.03226746
35histone H3-K9 demethylation (GO:0033169)5.01343726
36phosphatidylethanolamine biosynthetic process (GO:0006646)4.96656091
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83236379
38RNA destabilization (GO:0050779)4.81714371
39regulation of cilium movement (GO:0003352)4.74681690
40regulation of meiosis I (GO:0060631)4.63595736
41positive regulation of Rab GTPase activity (GO:0032851)4.63169694
42regulation of Rab GTPase activity (GO:0032313)4.63169694
43phosphatidylethanolamine metabolic process (GO:0046337)4.57700444
44male meiosis I (GO:0007141)4.56555924
45cilium or flagellum-dependent cell motility (GO:0001539)4.39499105
46single fertilization (GO:0007338)4.38131279
47DNA methylation involved in gamete generation (GO:0043046)4.27481166
48microtubule nucleation (GO:0007020)4.26289372
49male meiosis (GO:0007140)4.25841566
50microtubule severing (GO:0051013)4.24826497
51sexual reproduction (GO:0019953)4.24514812
52fertilization (GO:0009566)4.23700967
53multicellular organismal reproductive process (GO:0048609)4.18699664
54negative regulation of inclusion body assembly (GO:0090084)4.09958817
55mast cell activation involved in immune response (GO:0002279)4.05572898
56mast cell degranulation (GO:0043303)4.05572898
57germ cell development (GO:0007281)4.02768838
58cellular process involved in reproduction in multicellular organism (GO:0022412)3.77812630
59motile cilium assembly (GO:0044458)3.75348915
60meiotic nuclear division (GO:0007126)3.72752793
61meiosis I (GO:0007127)3.70520286
62regulation of transcription involved in cell fate commitment (GO:0060850)3.69297779
63response to acidic pH (GO:0010447)3.67249177
64epithelial cilium movement (GO:0003351)3.62727262
65cell wall macromolecule metabolic process (GO:0044036)3.61083013
66cell wall macromolecule catabolic process (GO:0016998)3.55110019
67glomerular visceral epithelial cell development (GO:0072015)3.43013541
68cellular response to pH (GO:0071467)3.39312263
69nucleus organization (GO:0006997)3.36983754
70musculoskeletal movement (GO:0050881)3.35114402
71multicellular organismal movement (GO:0050879)3.35114402
72regulation of T-helper 2 cell differentiation (GO:0045628)3.33691157
73glycerol ether metabolic process (GO:0006662)3.27909002
74synaptonemal complex assembly (GO:0007130)3.25683784
75chromosome organization involved in meiosis (GO:0070192)3.24709559
76membrane protein intracellular domain proteolysis (GO:0031293)3.21864265
77glomerular epithelial cell development (GO:0072310)3.19224261
78synapsis (GO:0007129)3.15802875
79polyamine biosynthetic process (GO:0006596)3.14113355
80negative regulation of Rho protein signal transduction (GO:0035024)3.11434552
81axoneme assembly (GO:0035082)3.10358773
82regulation of cytokine production involved in inflammatory response (GO:1900015)3.09234848
83regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09162630
84cilium movement (GO:0003341)3.07548320
85homeostasis of number of cells within a tissue (GO:0048873)3.07226974
86leukocyte degranulation (GO:0043299)3.06893313
87synaptonemal complex organization (GO:0070193)3.05663778
88cellular ketone body metabolic process (GO:0046950)3.02143642
89ketone body metabolic process (GO:1902224)3.00712939
90centrosome duplication (GO:0051298)3.00372133
91ether metabolic process (GO:0018904)2.99918695
92Golgi to endosome transport (GO:0006895)2.99612022
93intra-Golgi vesicle-mediated transport (GO:0006891)2.98535832
94organic cation transport (GO:0015695)2.97547998
95growth hormone receptor signaling pathway (GO:0060396)2.97249977
96nuclear pore complex assembly (GO:0051292)2.95401300
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.86594915
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.85969174
99regulation of microtubule-based movement (GO:0060632)2.85130563
100sperm motility (GO:0030317)10.3874255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.42123830
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.24662788
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48712974
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92422011
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31169315
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30843533
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17383864
8CBP_20019798_ChIP-Seq_JUKART_Human2.11070590
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.11070590
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.03532819
11FUS_26573619_Chip-Seq_HEK293_Human2.00206192
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95072457
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95072457
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87722108
15ZNF274_21170338_ChIP-Seq_K562_Hela1.87700653
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.85921359
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84845216
18RUNX_20019798_ChIP-Seq_JUKART_Human1.76511112
19ERA_21632823_ChIP-Seq_H3396_Human1.73007835
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.72880734
21VDR_22108803_ChIP-Seq_LS180_Human1.72636636
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71510039
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68565902
24SMAD4_21741376_ChIP-Seq_EPCs_Human1.64340528
25RAC3_21632823_ChIP-Seq_H3396_Human1.63839320
26ER_23166858_ChIP-Seq_MCF-7_Human1.61725964
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57597605
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.57227018
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56662823
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56315783
31CBX2_22325352_ChIP-Seq_293T-Rex_Human1.54874377
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53797548
33TAF2_19829295_ChIP-Seq_ESCs_Human1.52693529
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52679417
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.51464862
36MYC_19829295_ChIP-Seq_ESCs_Human1.50957497
37ETV1_20927104_ChIP-Seq_GIST48_Human1.50876052
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.49467560
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49205932
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49012611
41RBPJ_21746931_ChIP-Seq_IB4_Human1.48043747
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47145899
43HNFA_21074721_ChIP-Seq_CACO-2_Human1.46491466
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45768483
45NANOG_20526341_ChIP-Seq_ESCs_Human1.44401926
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44217237
47EZH2_22144423_ChIP-Seq_EOC_Human1.43748615
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43402243
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.41511916
50NFYB_21822215_ChIP-Seq_K562_Human1.41346201
51GATA6_21074721_ChIP-Seq_CACO-2_Human1.39626453
52BCL6_27268052_Chip-Seq_Bcells_Human1.39445107
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38233552
54CEBPB_22108803_ChIP-Seq_LS180_Human1.37717987
55BCOR_27268052_Chip-Seq_Bcells_Human1.36757446
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.35612919
57PHF8_20622853_ChIP-Seq_HELA_Human1.34889622
58OCT4_20526341_ChIP-Seq_ESCs_Human1.34809551
59MYB_26560356_Chip-Seq_TH2_Human1.34161446
60TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.31642643
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.31582873
62SALL4_22934838_ChIP-ChIP_CD34+_Human1.30776983
63ERG_20517297_ChIP-Seq_VCAP_Human1.30395678
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30308215
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28515815
66GATA3_27048872_Chip-Seq_THYMUS_Human1.26829051
67E2F1_20622854_ChIP-Seq_HELA_Human1.26305215
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26193327
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.26193327
70CTCF_20526341_ChIP-Seq_ESCs_Human1.25290287
71P300_19829295_ChIP-Seq_ESCs_Human1.24961577
72DROSHA_22980978_ChIP-Seq_HELA_Human1.24891322
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23135226
74P300_27268052_Chip-Seq_Bcells_Human1.21574685
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21183756
76AR_21572438_ChIP-Seq_LNCaP_Human1.19685913
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18632870
78GATA3_26560356_Chip-Seq_TH2_Human1.17597722
79PHF8_20622854_ChIP-Seq_HELA_Human1.16748775
80GATA3_26560356_Chip-Seq_TH1_Human1.15817000
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15753054
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.15632303
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14398546
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.13140096
85AR_25329375_ChIP-Seq_VCAP_Human1.12992518
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.12656668
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12060466
88TBL1_22424771_ChIP-Seq_293T_Human1.11400051
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11198251
90P68_20966046_ChIP-Seq_HELA_Human1.10863003
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07789071
92NCOR_22424771_ChIP-Seq_293T_Human1.07583123
93TAF15_26573619_Chip-Seq_HEK293_Human1.07222201
94NFYA_21822215_ChIP-Seq_K562_Human1.06980121
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06411269
96GBX2_23144817_ChIP-Seq_PC3_Human1.06391098
97SMRT_27268052_Chip-Seq_Bcells_Human1.05438407
98FOXH1_21741376_ChIP-Seq_EPCs_Human1.04830103
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04710015
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.04523061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.18717935
2MP0005377_hearing/vestibular/ear_phenot4.48559362
3MP0003878_abnormal_ear_physiology4.48559362
4MP0003698_abnormal_male_reproductive3.71431424
5MP0001929_abnormal_gametogenesis3.38332671
6MP0005670_abnormal_white_adipose3.19433170
7MP0002138_abnormal_hepatobiliary_system2.72628805
8MP0001348_abnormal_lacrimal_gland2.51890312
9MP0003646_muscle_fatigue2.39944720
10MP0005671_abnormal_response_to2.35890066
11MP0000372_irregular_coat_pigmentation2.32008576
12MP0009785_altered_susceptibility_to2.18725737
13MP0001835_abnormal_antigen_presentation2.05131233
14MP0000015_abnormal_ear_pigmentation1.97292350
15MP0005310_abnormal_salivary_gland1.93687208
16MP0002161_abnormal_fertility/fecundity1.88895041
17MP0000569_abnormal_digit_pigmentation1.88631342
18MP0002210_abnormal_sex_determination1.84315835
19MP0003718_maternal_effect1.77680006
20MP0008877_abnormal_DNA_methylation1.76661071
21MP0009333_abnormal_splenocyte_physiolog1.70954454
22MP0000678_abnormal_parathyroid_gland1.64307840
23MP0001986_abnormal_taste_sensitivity1.61731780
24MP0001984_abnormal_olfaction1.61635630
25MP0003806_abnormal_nucleotide_metabolis1.56968828
26MP0005075_abnormal_melanosome_morpholog1.53676368
27MP0005451_abnormal_body_composition1.51980786
28MP0002822_catalepsy1.47942206
29MP0002132_abnormal_respiratory_system1.43959308
30MP0005000_abnormal_immune_tolerance1.39603076
31MP0005408_hypopigmentation1.39383050
32MP0001145_abnormal_male_reproductive1.36302725
33MP0001849_ear_inflammation1.35299096
34MP0001790_abnormal_immune_system1.33801132
35MP0005387_immune_system_phenotype1.33801132
36MP0000653_abnormal_sex_gland1.31452676
37MP0005379_endocrine/exocrine_gland_phen1.29919034
38MP0004510_myositis1.24141289
39MP0001485_abnormal_pinna_reflex1.16305710
40MP0003436_decreased_susceptibility_to1.12018853
41MP0001800_abnormal_humoral_immune1.10559103
42MP0003879_abnormal_hair_cell1.10014673
43MP0008961_abnormal_basal_metabolism1.07649705
44MP0002735_abnormal_chemical_nociception1.07644401
45MP0002723_abnormal_immune_serum1.07255163
46MP0004742_abnormal_vestibular_system1.05850246
47MP0005167_abnormal_blood-brain_barrier1.04884558
48MP0001873_stomach_inflammation1.03594077
49MP0004147_increased_porphyrin_level1.00862206
50MP0002282_abnormal_trachea_morphology1.00249471
51MP0000371_diluted_coat_color1.00223051
52MP0004381_abnormal_hair_follicle0.99874639
53MP0005174_abnormal_tail_pigmentation0.96006340
54MP0003136_yellow_coat_color0.93463552
55MP0001765_abnormal_ion_homeostasis0.91790768
56MP0010155_abnormal_intestine_physiology0.91698034
57MP0005464_abnormal_platelet_physiology0.90800893
58MP0009765_abnormal_xenobiotic_induced0.89942403
59MP0001968_abnormal_touch/_nociception0.89365098
60MP0005025_abnormal_response_to0.85265836
61MP0002653_abnormal_ependyma_morphology0.84210289
62MP0001486_abnormal_startle_reflex0.80918893
63MP0001243_abnormal_dermal_layer0.80304481
64MP0002452_abnormal_antigen_presenting0.80296181
65MP0009764_decreased_sensitivity_to0.79628184
66MP0002095_abnormal_skin_pigmentation0.79614142
67MP0000685_abnormal_immune_system0.79301794
68MP0003448_altered_tumor_morphology0.78935522
69MP0002166_altered_tumor_susceptibility0.78727997
70MP0005636_abnormal_mineral_homeostasis0.75511621
71MP0003011_delayed_dark_adaptation0.75313209
72MP0005551_abnormal_eye_electrophysiolog0.75165681
73MP0005253_abnormal_eye_physiology0.74954769
74MP0002876_abnormal_thyroid_physiology0.74923372
75MP0009115_abnormal_fat_cell0.74518235
76MP0003724_increased_susceptibility_to0.74167088
77MP0004947_skin_inflammation0.72756625
78MP0002420_abnormal_adaptive_immunity0.72750064
79MP0001666_abnormal_nutrient_absorption0.72067629
80MP0001819_abnormal_immune_cell0.71493880
81MP0000703_abnormal_thymus_morphology0.71020453
82MP0002405_respiratory_system_inflammati0.70085855
83MP0002419_abnormal_innate_immunity0.69225453
84MP0005535_abnormal_body_temperature0.67726153
85MP0010307_abnormal_tumor_latency0.66481133
86MP0001963_abnormal_hearing_physiology0.64910292
87MP0002229_neurodegeneration0.64355676
88MP0002398_abnormal_bone_marrow0.64162743
89MP0002933_joint_inflammation0.63912828
90MP0004036_abnormal_muscle_relaxation0.63060764
91MP0002722_abnormal_immune_system0.62597335
92MP0008569_lethality_at_weaning0.61231781
93MP0008775_abnormal_heart_ventricle0.60943761
94MP0008995_early_reproductive_senescence0.60638916
95MP0004084_abnormal_cardiac_muscle0.59167396
96MP0000230_abnormal_systemic_arterial0.57431571
97MP0005666_abnormal_adipose_tissue0.56452873
98MP0000249_abnormal_blood_vessel0.54298312
99MP0001853_heart_inflammation0.53942636
100MP0005171_absent_coat_pigmentation0.53858014

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.49803177
2Absent/shortened dynein arms (HP:0200106)5.35729160
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.35729160
4Tubulointerstitial nephritis (HP:0001970)5.25952670
5Chronic hepatic failure (HP:0100626)4.67898968
6Nasal polyposis (HP:0100582)4.64264134
7Asymmetric septal hypertrophy (HP:0001670)4.19869482
8Hyperkalemia (HP:0002153)3.91258761
9Abnormal ciliary motility (HP:0012262)3.91124223
10Enlarged epiphyses (HP:0010580)3.77489111
11Abnormal respiratory motile cilium physiology (HP:0012261)3.77143434
12Abnormal respiratory epithelium morphology (HP:0012253)3.75037129
13Abnormal respiratory motile cilium morphology (HP:0005938)3.75037129
14Male infertility (HP:0003251)3.74023889
15Attenuation of retinal blood vessels (HP:0007843)3.72118371
16Abnormality of the nasal mucosa (HP:0000433)3.67885688
17Menstrual irregularities (HP:0000858)3.65709147
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.42553610
19Abnormality of macular pigmentation (HP:0008002)3.38495728
20Potter facies (HP:0002009)3.37090051
21Facial shape deformation (HP:0011334)3.37090051
22Amelogenesis imperfecta (HP:0000705)3.31902562
23Cone-rod dystrophy (HP:0000548)3.30831772
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.30125413
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29751712
26Elevated erythrocyte sedimentation rate (HP:0003565)3.27848861
27Infertility (HP:0000789)3.26539853
28Resting tremor (HP:0002322)3.26515868
29Impulsivity (HP:0100710)3.19956817
30Bony spicule pigmentary retinopathy (HP:0007737)3.09806894
31Abnormality of the costochondral junction (HP:0000919)3.05062823
32Abnormal spermatogenesis (HP:0008669)3.02768076
33Abnormality of dental color (HP:0011073)3.01620916
34Generalized aminoaciduria (HP:0002909)2.94932407
35Hypoplasia of the thymus (HP:0000778)2.93141625
36Recurrent cutaneous fungal infections (HP:0011370)2.82945825
37Chronic mucocutaneous candidiasis (HP:0002728)2.82945825
38Truncal obesity (HP:0001956)2.81050959
39Portal hypertension (HP:0001409)2.79483220
40Progressive sensorineural hearing impairment (HP:0000408)2.71250659
41Horizontal nystagmus (HP:0000666)2.70951097
42Bell-shaped thorax (HP:0001591)2.64837078
43Hypoalphalipoproteinemia (HP:0003233)2.54748889
44Azoospermia (HP:0000027)2.54323318
45Bronchiectasis (HP:0002110)2.53186047
46Abnormality of the hepatic vasculature (HP:0006707)2.53024508
47Tubulointerstitial abnormality (HP:0001969)2.37785479
48Nephronophthisis (HP:0000090)2.35851911
49Abnormal rod and cone electroretinograms (HP:0008323)2.29990542
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.29079111
51Hypoplasia of the fovea (HP:0007750)2.29079111
52Volvulus (HP:0002580)2.25454427
53Stage 5 chronic kidney disease (HP:0003774)2.24245248
54Abnormality of placental membranes (HP:0011409)2.23923849
55Amniotic constriction ring (HP:0009775)2.23923849
56Rhinitis (HP:0012384)2.20739668
57Abnormality of transition element cation homeostasis (HP:0011030)2.20214096
58Postural instability (HP:0002172)2.19970932
59Decreased central vision (HP:0007663)2.19961787
60Insulin-resistant diabetes mellitus (HP:0000831)2.18636000
61Abnormality of potassium homeostasis (HP:0011042)2.18152218
62Abnormality of the renal medulla (HP:0100957)2.15886250
63Abnormality of the fingertips (HP:0001211)2.15762064
64Renovascular hypertension (HP:0100817)2.14799649
65Aplasia/Hypoplasia of the macula (HP:0008059)2.09121828
66Progressive cerebellar ataxia (HP:0002073)2.08971686
67Stomatitis (HP:0010280)2.08666573
68Abnormality of T cells (HP:0002843)2.08346229
69Osteomalacia (HP:0002749)2.06942198
70Joint swelling (HP:0001386)2.06788711
71Abnormal urine output (HP:0012590)2.06591108
72Congenital sensorineural hearing impairment (HP:0008527)2.05366858
73T lymphocytopenia (HP:0005403)2.03420434
74Widely patent fontanelles and sutures (HP:0004492)1.99661797
75Pulmonary fibrosis (HP:0002206)1.97618497
76Hypoalbuminemia (HP:0003073)1.96116526
77Abnormal albumin level (HP:0012116)1.96116526
78Abnormality of T cell number (HP:0011839)1.94868553
79Recurrent pneumonia (HP:0006532)1.91753660
80Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91439963
81Abnormality of the fovea (HP:0000493)1.90805804
82IgG deficiency (HP:0004315)1.89384307
83Gastrointestinal infarctions (HP:0005244)1.88778745
84Abnormality of the renal cortex (HP:0011035)1.88717175
85Abnormality of renal excretion (HP:0011036)1.87778203
86Polydipsia (HP:0001959)1.87338424
87Abnormal drinking behavior (HP:0030082)1.87338424
88Abnormality of chloride homeostasis (HP:0011422)1.87258500
89Abnormality of T cell physiology (HP:0011840)1.84804471
90Chronic bronchitis (HP:0004469)1.84303659
91Cheilitis (HP:0100825)1.82460904
92Optic neuritis (HP:0100653)1.81993533
93Retrobulbar optic neuritis (HP:0100654)1.81993533
94Hemoptysis (HP:0002105)1.80227476
95Neoplasm of the heart (HP:0100544)1.79878443
96Supernumerary ribs (HP:0005815)1.77937178
97IgA deficiency (HP:0002720)1.76889798
98Hyperuricemia (HP:0002149)1.76568373
99Increased purine levels (HP:0004368)1.76568373
100Atonic seizures (HP:0010819)1.75383937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.49410966
2PNCK5.33593333
3PLK23.68843721
4INSRR3.65965543
5TESK13.27416422
6BRD43.12861156
7CAMK1G2.95449574
8STK38L2.71893920
9DDR22.35218104
10PTK2B2.22417843
11PIK3CG2.17186418
12STK382.14788686
13NEK12.14518364
14MET1.96798122
15MAP4K21.87941976
16MST1R1.79646902
17TXK1.53094816
18ZAK1.52449165
19NUAK11.37607068
20TYRO31.34920909
21PDK11.24036427
22TLK11.23281486
23BMX1.22425154
24PRKD31.21561079
25CSF1R1.11390942
26ITK1.10646915
27MAP4K11.09026341
28NEK61.07099747
29FGR0.99798365
30PDPK10.98045126
31MAPK150.94811794
32PIK3CA0.93979349
33WNK10.93675477
34SIK20.93600741
35CDK70.90009757
36CDK120.87729879
37MST40.86472413
38ACVR1B0.80026706
39TEC0.76063191
40DYRK1B0.74261301
41NEK20.65553469
42IKBKB0.65155518
43MARK30.63753673
44CAMK10.60615737
45ADRBK20.60476315
46STK30.60354595
47KSR20.58265620
48SYK0.58146083
49GRK60.55818046
50PINK10.55770744
51JAK30.55479645
52TBK10.53495247
53MAP2K20.53057634
54TRIM280.51769409
55WEE10.51235115
56RIPK40.48615973
57PRKG10.47919813
58PRKCQ0.47368248
59CAMK1D0.46594404
60TIE10.46126402
61ROCK10.45758101
62TESK20.43255544
63BLK0.42749898
64MAP3K20.41429413
65OXSR10.39074347
66MAPK110.39038556
67MAPK10.38060964
68RPS6KA10.37442907
69RET0.37247151
70STK240.36803925
71VRK10.36042877
72CHEK10.35774767
73PRKCH0.35281270
74LATS10.34230975
75PRKAA20.32730881
76TAF10.32610954
77CDK10.32285495
78BTK0.32264419
79CHUK0.31088802
80IKBKE0.30587442
81PAK10.29208843
82MAP2K60.27284260
83EIF2AK10.26871866
84CDK20.24693839
85EGFR0.23743354
86CSK0.23535538
87PKN10.22406194
88MAP3K80.21719937
89PRKAA10.21539132
90CAMK2A0.20877451
91PRKCB0.20287978
92TNK20.19866428
93MAP3K140.19689512
94MAP3K110.18327164
95ATR0.18139333
96CDK30.18054882
97IGF1R0.16917045
98LYN0.16794207
99MAP3K90.16711478
100GSK3B0.16117384

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.38981235
2Fatty acid biosynthesis_Homo sapiens_hsa000614.32736061
3Allograft rejection_Homo sapiens_hsa053303.89608755
4Antigen processing and presentation_Homo sapiens_hsa046123.77751339
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.68974267
6Autoimmune thyroid disease_Homo sapiens_hsa053203.26411482
7Type I diabetes mellitus_Homo sapiens_hsa049403.07612635
8Olfactory transduction_Homo sapiens_hsa047402.97902163
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.62471615
10Primary immunodeficiency_Homo sapiens_hsa053402.37777178
11Nitrogen metabolism_Homo sapiens_hsa009102.27737907
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23255692
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.98662739
14Systemic lupus erythematosus_Homo sapiens_hsa053221.83182628
15RNA transport_Homo sapiens_hsa030131.77269682
16Viral myocarditis_Homo sapiens_hsa054161.44499123
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.39807347
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.39422439
19Proteasome_Homo sapiens_hsa030501.38071811
20T cell receptor signaling pathway_Homo sapiens_hsa046601.37459481
21Dorso-ventral axis formation_Homo sapiens_hsa043201.35513595
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35226688
23Taste transduction_Homo sapiens_hsa047421.27588979
24Measles_Homo sapiens_hsa051621.18917999
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18640603
26Regulation of autophagy_Homo sapiens_hsa041401.18428479
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.18007626
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17862501
29Viral carcinogenesis_Homo sapiens_hsa052031.16462102
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14236435
31Fanconi anemia pathway_Homo sapiens_hsa034601.12570534
32Hematopoietic cell lineage_Homo sapiens_hsa046401.10823925
33Oocyte meiosis_Homo sapiens_hsa041141.01805432
34Influenza A_Homo sapiens_hsa051641.00720209
35Herpes simplex infection_Homo sapiens_hsa051680.99009729
36Phototransduction_Homo sapiens_hsa047440.97875256
37Type II diabetes mellitus_Homo sapiens_hsa049300.92911761
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92890373
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90872176
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.90572705
41Fatty acid metabolism_Homo sapiens_hsa012120.82709609
42Alcoholism_Homo sapiens_hsa050340.82636903
43Fatty acid degradation_Homo sapiens_hsa000710.79241411
44Rheumatoid arthritis_Homo sapiens_hsa053230.75561625
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71645165
46Endocytosis_Homo sapiens_hsa041440.70084351
47Epstein-Barr virus infection_Homo sapiens_hsa051690.69288993
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.69001170
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67780257
50Inositol phosphate metabolism_Homo sapiens_hsa005620.67265061
51Phenylalanine metabolism_Homo sapiens_hsa003600.66881516
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66546388
53Butanoate metabolism_Homo sapiens_hsa006500.62529089
54Purine metabolism_Homo sapiens_hsa002300.61239890
55ABC transporters_Homo sapiens_hsa020100.57331035
56Synaptic vesicle cycle_Homo sapiens_hsa047210.57284352
57Asthma_Homo sapiens_hsa053100.54801963
58VEGF signaling pathway_Homo sapiens_hsa043700.54209295
59Chemokine signaling pathway_Homo sapiens_hsa040620.54134646
60mRNA surveillance pathway_Homo sapiens_hsa030150.53400732
61Basal transcription factors_Homo sapiens_hsa030220.52283976
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50433388
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49463049
64Legionellosis_Homo sapiens_hsa051340.47252541
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46700160
66Calcium signaling pathway_Homo sapiens_hsa040200.45925202
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45481440
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44846798
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43677044
70Linoleic acid metabolism_Homo sapiens_hsa005910.43004944
71Morphine addiction_Homo sapiens_hsa050320.42272038
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41695637
73Circadian rhythm_Homo sapiens_hsa047100.40075799
74Protein digestion and absorption_Homo sapiens_hsa049740.39572320
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39272376
76B cell receptor signaling pathway_Homo sapiens_hsa046620.37140716
77Retinol metabolism_Homo sapiens_hsa008300.36645395
78African trypanosomiasis_Homo sapiens_hsa051430.36329841
79Malaria_Homo sapiens_hsa051440.35609160
80Toxoplasmosis_Homo sapiens_hsa051450.34030550
81N-Glycan biosynthesis_Homo sapiens_hsa005100.33914695
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32634648
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32594219
84Leishmaniasis_Homo sapiens_hsa051400.32289620
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31380231
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29987636
87Salivary secretion_Homo sapiens_hsa049700.28583697
88Osteoclast differentiation_Homo sapiens_hsa043800.28333413
89Arginine and proline metabolism_Homo sapiens_hsa003300.27848922
90Serotonergic synapse_Homo sapiens_hsa047260.27819743
91Glycerolipid metabolism_Homo sapiens_hsa005610.25628090
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.22936047
93Fat digestion and absorption_Homo sapiens_hsa049750.22798427
94Non-small cell lung cancer_Homo sapiens_hsa052230.22619320
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20546895
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19768891
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19639239
98Tyrosine metabolism_Homo sapiens_hsa003500.19418516
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19364655
100Biosynthesis of amino acids_Homo sapiens_hsa012300.18487290

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