ZDHHC21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)3.87078211
2presynaptic membrane assembly (GO:0097105)3.75864918
3G-protein coupled receptor internalization (GO:0002031)3.48509983
4ionotropic glutamate receptor signaling pathway (GO:0035235)3.41362473
5presynaptic membrane organization (GO:0097090)3.37147836
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28981406
7Golgi to endosome transport (GO:0006895)3.27191717
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24202473
9negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23763094
10glutamate receptor signaling pathway (GO:0007215)3.21870401
11postsynaptic membrane organization (GO:0001941)3.20652642
12vocalization behavior (GO:0071625)3.19450366
13righting reflex (GO:0060013)3.15778430
14regulation of protein glycosylation (GO:0060049)3.09341587
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07624273
16startle response (GO:0001964)3.07240314
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.03865725
18synaptic vesicle docking involved in exocytosis (GO:0016081)2.98838614
19dendritic spine morphogenesis (GO:0060997)2.95762940
20proline transport (GO:0015824)2.95426513
21establishment of nucleus localization (GO:0040023)2.93885720
22histone H3-K4 trimethylation (GO:0080182)2.92813451
23negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86006580
24nucleus localization (GO:0051647)2.85948523
25cerebral cortex radially oriented cell migration (GO:0021799)2.84769841
26interkinetic nuclear migration (GO:0022027)2.84291382
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82880708
28protein localization to synapse (GO:0035418)2.82534093
29positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81609153
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81373453
31neuron recognition (GO:0008038)2.80287291
32transmission of nerve impulse (GO:0019226)2.79687076
33establishment of protein localization to Golgi (GO:0072600)2.78924674
34cerebellar Purkinje cell differentiation (GO:0021702)2.78877633
35regulation of glutamate receptor signaling pathway (GO:1900449)2.76451458
36detection of calcium ion (GO:0005513)2.74662442
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68080151
38phospholipid translocation (GO:0045332)2.67986833
39lipid translocation (GO:0034204)2.67986833
40glutamate secretion (GO:0014047)2.67216595
41long-chain fatty acid biosynthetic process (GO:0042759)2.65847148
42neurotransmitter-gated ion channel clustering (GO:0072578)2.62828353
43regulation of pigment cell differentiation (GO:0050932)2.62817766
44kidney morphogenesis (GO:0060993)2.62139097
45gamma-aminobutyric acid signaling pathway (GO:0007214)2.61428548
46L-amino acid import (GO:0043092)2.61264942
47regulation of timing of cell differentiation (GO:0048505)2.60307040
48vascular smooth muscle contraction (GO:0014829)2.58680034
49axonal fasciculation (GO:0007413)2.58158669
50artery development (GO:0060840)2.58142726
51cell morphogenesis involved in neuron differentiation (GO:0048667)2.57993168
52cellular potassium ion homeostasis (GO:0030007)2.57666443
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57183822
54limb bud formation (GO:0060174)2.56448721
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56020338
56neuron fate determination (GO:0048664)2.55790470
57regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55788622
58synaptic vesicle maturation (GO:0016188)2.55569646
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55160136
60innervation (GO:0060384)2.54100113
61C4-dicarboxylate transport (GO:0015740)2.53952149
62atrial cardiac muscle cell action potential (GO:0086014)2.53938770
63positive regulation of synapse assembly (GO:0051965)2.53555167
64protein targeting to Golgi (GO:0000042)2.52278738
65regulation of platelet aggregation (GO:0090330)2.52099820
66neuronal action potential (GO:0019228)2.50240500
67positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.48132525
68regulation of synapse assembly (GO:0051963)2.47914006
69regulation of postsynaptic membrane potential (GO:0060078)2.47110682
70central nervous system projection neuron axonogenesis (GO:0021952)2.46263401
71synaptic transmission, glutamatergic (GO:0035249)2.45140986
72suckling behavior (GO:0001967)2.44983431
73developmental pigmentation (GO:0048066)2.44294481
74neuron-neuron synaptic transmission (GO:0007270)2.43557268
75calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43281649
76limb development (GO:0060173)2.42463830
77appendage development (GO:0048736)2.42463830
78neuronal action potential propagation (GO:0019227)2.42284931
79serotonin metabolic process (GO:0042428)2.42006730
80gamma-aminobutyric acid transport (GO:0015812)2.41998829
81locomotory exploration behavior (GO:0035641)2.40240484
82regulation of NIK/NF-kappaB signaling (GO:1901222)2.39725811
83regulation of germinal center formation (GO:0002634)2.39170194
84regulation of sarcomere organization (GO:0060297)2.38727275
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38422533
86positive regulation of cardiac muscle cell differentiation (GO:2000727)2.37794014
87nonmotile primary cilium assembly (GO:0035058)2.37235963
88negative regulation of hormone biosynthetic process (GO:0032353)2.36908100
89axon ensheathment in central nervous system (GO:0032291)2.36219329
90central nervous system myelination (GO:0022010)2.36219329
91regulation of dendritic spine morphogenesis (GO:0061001)2.36126043
92relaxation of cardiac muscle (GO:0055119)2.34931724
93neuron remodeling (GO:0016322)2.32878803
94negative regulation of neurotransmitter transport (GO:0051589)2.32835926
95potassium ion import (GO:0010107)2.32693161
96retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32651411
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31947122
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.31577648
99cochlea development (GO:0090102)2.31444661
100regulation of synaptic vesicle exocytosis (GO:2000300)2.31102705
101positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30068378
102nerve growth factor signaling pathway (GO:0038180)2.29941277
103cellular sodium ion homeostasis (GO:0006883)2.29936642
104renal tubule morphogenesis (GO:0061333)2.29779499
105positive regulation of cellular amide metabolic process (GO:0034250)2.29227468
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29201654
107reflex (GO:0060004)2.29020248
108action potential (GO:0001508)2.28920164
109cell communication involved in cardiac conduction (GO:0086065)2.28472150
110neurotransmitter uptake (GO:0001504)2.28074291
111glycosphingolipid biosynthetic process (GO:0006688)2.27946036
112positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.27850143
113membrane depolarization (GO:0051899)2.27675584
114negative regulation of dendrite development (GO:2000171)2.27635502
115embryonic foregut morphogenesis (GO:0048617)2.26548588
116long-term memory (GO:0007616)2.26353906
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.25680641
118negative regulation of neurotransmitter secretion (GO:0046929)2.25625970
119regulation of respiratory system process (GO:0044065)2.25582055
120membrane depolarization during action potential (GO:0086010)2.25370912
121neurotransmitter secretion (GO:0007269)2.24342139
122regulation of clathrin-mediated endocytosis (GO:2000369)2.24196145
123cilium or flagellum-dependent cell motility (GO:0001539)2.24039499
124central nervous system neuron axonogenesis (GO:0021955)2.22872469
125regulation of synaptic vesicle transport (GO:1902803)2.22050824
126homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.21888900
127positive regulation of action potential (GO:0045760)2.21757606
128retina layer formation (GO:0010842)2.21293431
129regulation of memory T cell differentiation (GO:0043380)2.20513721
130dendritic spine organization (GO:0097061)2.20449146
131dendrite morphogenesis (GO:0048813)2.20170018
132regulation of dendritic spine development (GO:0060998)2.19400733
133regulation of respiratory gaseous exchange (GO:0043576)2.18808418
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.18426626
135spinal cord motor neuron differentiation (GO:0021522)2.18384669
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.17555391
137regulation of translation, ncRNA-mediated (GO:0045974)2.17555391
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.17555391
139amino acid import (GO:0043090)2.17458487
140synapse assembly (GO:0007416)2.17432628
141cell proliferation in forebrain (GO:0021846)2.17296542
142regulation of inositol phosphate biosynthetic process (GO:0010919)2.16796685
143cranial nerve morphogenesis (GO:0021602)2.15759869
144adult walking behavior (GO:0007628)2.14739067
145inner ear receptor stereocilium organization (GO:0060122)2.14110169
146regulation of synaptic transmission, GABAergic (GO:0032228)2.13706214
147left/right axis specification (GO:0070986)2.13521656
148germinal center formation (GO:0002467)2.12776642
149positive regulation of dendritic spine development (GO:0060999)2.12393824
150negative regulation of homotypic cell-cell adhesion (GO:0034111)2.11723147
151response to auditory stimulus (GO:0010996)2.11091452
152calcium ion import (GO:0070509)2.10761509
153auditory behavior (GO:0031223)2.09688420
154exploration behavior (GO:0035640)2.09425782
155regulation of somitogenesis (GO:0014807)2.08681335
156eye photoreceptor cell differentiation (GO:0001754)2.08349895
157photoreceptor cell differentiation (GO:0046530)2.08349895
158positive regulation of protein dephosphorylation (GO:0035307)2.08267022
159mechanosensory behavior (GO:0007638)2.08052109
160positive regulation of synaptic transmission, GABAergic (GO:0032230)2.07924196
161regulation of development, heterochronic (GO:0040034)2.05447782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.84005322
2GBX2_23144817_ChIP-Seq_PC3_Human3.80452144
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45087880
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44128107
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31855366
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17425243
7TAF15_26573619_Chip-Seq_HEK293_Human2.14771053
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.12785245
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07262251
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06446283
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02426532
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02259927
13AR_21572438_ChIP-Seq_LNCaP_Human2.01817536
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.96371447
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92776558
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92738526
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92173245
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90378169
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89494889
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87766970
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87579166
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.85708085
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85212878
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83538854
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.83490147
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80016050
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78579063
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78437069
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78437069
30P300_19829295_ChIP-Seq_ESCs_Human1.75735257
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.75616041
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73253289
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71978794
34DROSHA_22980978_ChIP-Seq_HELA_Human1.71510272
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71018077
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70850250
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69255578
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.68414488
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.68348918
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67310985
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.66812947
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.66185726
43ZNF274_21170338_ChIP-Seq_K562_Hela1.63868084
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62559965
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60997609
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58833202
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.58491951
48IGF1R_20145208_ChIP-Seq_DFB_Human1.57964467
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.56988478
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.56761633
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.55745193
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.54745099
53FUS_26573619_Chip-Seq_HEK293_Human1.53160110
54P53_22387025_ChIP-Seq_ESCs_Mouse1.52501116
55* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51341774
56BCAT_22108803_ChIP-Seq_LS180_Human1.51262940
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50461179
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49879674
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.49307713
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46724083
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43342785
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41072620
63RNF2_27304074_Chip-Seq_NSC_Mouse1.41066431
64P300_18555785_Chip-Seq_ESCs_Mouse1.39164271
65STAT3_23295773_ChIP-Seq_U87_Human1.39098830
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38976950
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38165158
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.37792902
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37446923
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37446923
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36980813
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36738616
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.35223338
74REST_21632747_ChIP-Seq_MESCs_Mouse1.34865981
75* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33231984
76VDR_22108803_ChIP-Seq_LS180_Human1.33082240
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32076513
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32076513
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31830571
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31184433
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31077453
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29798763
83TP53_18474530_ChIP-ChIP_U2OS_Human1.29436806
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29071172
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.28696424
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28647747
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28306944
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.28266705
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27821756
90CBP_20019798_ChIP-Seq_JUKART_Human1.27821756
91TCF4_23295773_ChIP-Seq_U87_Human1.27582372
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.26600481
93ER_23166858_ChIP-Seq_MCF-7_Human1.25374830
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25218230
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24496277
96AHR_22903824_ChIP-Seq_MCF-7_Human1.24338903
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.23876226
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23845545
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23804526
100PU1_27457419_Chip-Seq_LIVER_Mouse1.23120123
101TP53_16413492_ChIP-PET_HCT116_Human1.21324992
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21117122
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21000043
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20196813
105RUNX2_22187159_ChIP-Seq_PCA_Human1.19526793
106TCF4_22108803_ChIP-Seq_LS180_Human1.18708929
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.18491150
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18027236
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.17973665
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17809675
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17673270
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17391328
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17170078
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.16861978
115EWS_26573619_Chip-Seq_HEK293_Human1.16646636
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16532131
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16152608
118AR_25329375_ChIP-Seq_VCAP_Human1.15956394
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.15083127
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13200865
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.12364327
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12260316
123* KDM2B_26808549_Chip-Seq_REH_Human1.12228927
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12122077
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.11634815
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.11604215
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11210951
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10823110
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10124448
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08951137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.84010034
2MP0001188_hyperpigmentation3.73137148
3MP0000569_abnormal_digit_pigmentation3.01243976
4MP0004859_abnormal_synaptic_plasticity2.92902353
5MP0003136_yellow_coat_color2.78800437
6MP0005409_darkened_coat_color2.78771787
7MP0009046_muscle_twitch2.76036806
8MP0001486_abnormal_startle_reflex2.60760848
9MP0005423_abnormal_somatic_nervous2.58833847
10MP0003890_abnormal_embryonic-extraembry2.41266756
11MP0004381_abnormal_hair_follicle2.37521729
12MP0004742_abnormal_vestibular_system2.30711388
13MP0000566_synostosis2.27269537
14MP0003635_abnormal_synaptic_transmissio2.26764418
15MP0001968_abnormal_touch/_nociception2.24005824
16MP0009745_abnormal_behavioral_response2.21371992
17MP0002735_abnormal_chemical_nociception2.19464486
18MP0004270_analgesia2.14831046
19MP0002102_abnormal_ear_morphology2.14396627
20MP0008877_abnormal_DNA_methylation1.98826169
21MP0005645_abnormal_hypothalamus_physiol1.96567740
22MP0000778_abnormal_nervous_system1.96490807
23MP0005174_abnormal_tail_pigmentation1.89356165
24MP0002572_abnormal_emotion/affect_behav1.89046738
25MP0000579_abnormal_nail_morphology1.85551808
26MP0005171_absent_coat_pigmentation1.83361435
27MP0008057_abnormal_DNA_replication1.79768044
28MP0002734_abnormal_mechanical_nocicepti1.78187769
29MP0002063_abnormal_learning/memory/cond1.76828111
30MP0000015_abnormal_ear_pigmentation1.75717855
31MP0002064_seizures1.75621645
32MP0002067_abnormal_sensory_capabilities1.75478757
33MP0003122_maternal_imprinting1.72036717
34MP0001440_abnormal_grooming_behavior1.68455723
35MP0002272_abnormal_nervous_system1.64093057
36MP0002184_abnormal_innervation1.61237736
37MP0002736_abnormal_nociception_after1.61094872
38MP0004215_abnormal_myocardial_fiber1.52026630
39MP0002837_dystrophic_cardiac_calcinosis1.51894725
40MP0003787_abnormal_imprinting1.51079743
41MP0006292_abnormal_olfactory_placode1.50344086
42MP0006276_abnormal_autonomic_nervous1.46731682
43MP0004043_abnormal_pH_regulation1.45141630
44MP0002557_abnormal_social/conspecific_i1.43091023
45MP0001986_abnormal_taste_sensitivity1.38466021
46MP0003941_abnormal_skin_development1.38372692
47MP0003283_abnormal_digestive_organ1.37100660
48MP0005623_abnormal_meninges_morphology1.35192383
49MP0002733_abnormal_thermal_nociception1.34444537
50MP0001984_abnormal_olfaction1.33797994
51MP0001501_abnormal_sleep_pattern1.33177705
52MP0005379_endocrine/exocrine_gland_phen1.31998332
53MP0005551_abnormal_eye_electrophysiolog1.31441945
54MP0001970_abnormal_pain_threshold1.29424897
55MP0002277_abnormal_respiratory_mucosa1.29261676
56MP0002928_abnormal_bile_duct1.25412127
57MP0004142_abnormal_muscle_tone1.24741570
58MP0006072_abnormal_retinal_apoptosis1.24031898
59MP0003121_genomic_imprinting1.23435613
60MP0004133_heterotaxia1.22946223
61MP0003633_abnormal_nervous_system1.21641124
62MP0004145_abnormal_muscle_electrophysio1.21452197
63MP0002822_catalepsy1.20486363
64MP0002909_abnormal_adrenal_gland1.18102938
65MP0001879_abnormal_lymphatic_vessel1.17585416
66MP0000026_abnormal_inner_ear1.17124025
67* MP0000383_abnormal_hair_follicle1.15322414
68MP0001177_atelectasis1.14760677
69MP0005248_abnormal_Harderian_gland1.13715074
70MP0000955_abnormal_spinal_cord1.11460884
71MP0002882_abnormal_neuron_morphology1.10484990
72MP0000631_abnormal_neuroendocrine_gland1.10128099
73MP0001963_abnormal_hearing_physiology1.09408213
74MP0004484_altered_response_of1.07317423
75MP0008569_lethality_at_weaning1.05928740
76MP0004085_abnormal_heartbeat1.05403977
77MP0005187_abnormal_penis_morphology1.04098182
78MP0003183_abnormal_peptide_metabolism1.01725246
79MP0003938_abnormal_ear_development1.01523068
80MP0002095_abnormal_skin_pigmentation1.01522628
81MP0003045_fibrosis1.01486466
82MP0006054_spinal_hemorrhage1.01098824
83MP0000462_abnormal_digestive_system1.00292646
84MP0005386_behavior/neurological_phenoty0.99475895
85MP0004924_abnormal_behavior0.99475895
86MP0005646_abnormal_pituitary_gland0.98705365
87MP0001502_abnormal_circadian_rhythm0.98497004
88MP0002752_abnormal_somatic_nervous0.98494694
89MP0003195_calcinosis0.93867902
90MP0005253_abnormal_eye_physiology0.90058099
91MP0001299_abnormal_eye_distance/0.89884600
92MP0000013_abnormal_adipose_tissue0.88826360
93* MP0010678_abnormal_skin_adnexa0.88779643
94MP0010352_gastrointestinal_tract_polyps0.88372434
95MP0005257_abnormal_intraocular_pressure0.86722534
96MP0002638_abnormal_pupillary_reflex0.86683809
97MP0000920_abnormal_myelination0.85484747
98MP0010234_abnormal_vibrissa_follicle0.84356212
99MP0003868_abnormal_feces_composition0.81537081
100MP0010386_abnormal_urinary_bladder0.80997815
101MP0002066_abnormal_motor_capabilities/c0.79733171
102MP0002009_preneoplasia0.79276102
103MP0004084_abnormal_cardiac_muscle0.78199494
104MP0002177_abnormal_outer_ear0.77893040
105MP0004885_abnormal_endolymph0.77258697
106MP0002876_abnormal_thyroid_physiology0.77086975
107MP0001346_abnormal_lacrimal_gland0.76769287
108MP0002152_abnormal_brain_morphology0.75780081
109MP0005220_abnormal_exocrine_pancreas0.75514935
110MP0001905_abnormal_dopamine_level0.74793164
111MP0002751_abnormal_autonomic_nervous0.74257403
112MP0009780_abnormal_chondrocyte_physiolo0.73877753
113MP0001944_abnormal_pancreas_morphology0.73754268
114MP0010368_abnormal_lymphatic_system0.72655406
115MP0004811_abnormal_neuron_physiology0.71937561
116MP0002098_abnormal_vibrissa_morphology0.71897687
117MP0008260_abnormal_autophagy0.71191007
118MP0003879_abnormal_hair_cell0.70472671
119MP0005499_abnormal_olfactory_system0.69950167
120MP0005394_taste/olfaction_phenotype0.69950167
121MP0001485_abnormal_pinna_reflex0.69659332
122MP0002229_neurodegeneration0.68875168
123* MP0000427_abnormal_hair_cycle0.68579373
124MP0003632_abnormal_nervous_system0.68020334
125* MP0000647_abnormal_sebaceous_gland0.66624585
126MP0002249_abnormal_larynx_morphology0.65415539
127MP0005410_abnormal_fertilization0.64778976
128MP0000372_irregular_coat_pigmentation0.64080577
129MP0001661_extended_life_span0.61206027
130MP0003690_abnormal_glial_cell0.61193232
131MP0003631_nervous_system_phenotype0.60980560
132MP0003634_abnormal_glial_cell0.60265000
133MP0000538_abnormal_urinary_bladder0.59141624
134MP0005195_abnormal_posterior_eye0.58796760
135MP0002163_abnormal_gland_morphology0.56874337

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65227405
2Febrile seizures (HP:0002373)4.55881362
3Chromsome breakage (HP:0040012)4.13154023
4Upper limb muscle weakness (HP:0003484)4.01298508
5Focal motor seizures (HP:0011153)3.87985036
6Prostate neoplasm (HP:0100787)3.53861292
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.25016554
8Absent/shortened dynein arms (HP:0200106)3.25016554
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.24408819
10Medial flaring of the eyebrow (HP:0010747)3.22559318
11Gait imbalance (HP:0002141)3.09649221
12Intestinal atresia (HP:0011100)3.05120994
13Papillary thyroid carcinoma (HP:0002895)3.00078036
14Congenital stationary night blindness (HP:0007642)2.94808718
15Abnormal ciliary motility (HP:0012262)2.84216532
16Congenital primary aphakia (HP:0007707)2.83373936
17Duplicated collecting system (HP:0000081)2.79575901
18Chronic hepatic failure (HP:0100626)2.78700078
19Focal seizures (HP:0007359)2.76908271
20Abnormality of midbrain morphology (HP:0002418)2.75075801
21Molar tooth sign on MRI (HP:0002419)2.75075801
22Calf muscle hypertrophy (HP:0008981)2.74725747
23True hermaphroditism (HP:0010459)2.74234446
24Genital tract atresia (HP:0001827)2.72707638
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.71372260
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.71372260
27Aplasia cutis congenita (HP:0001057)2.67589381
28Pancreatic cysts (HP:0001737)2.66165775
29Vaginal atresia (HP:0000148)2.66029400
30Absent speech (HP:0001344)2.60249131
31Broad-based gait (HP:0002136)2.59474493
32Abnormality of the renal collecting system (HP:0004742)2.58588917
33Progressive cerebellar ataxia (HP:0002073)2.57898643
34Epileptic encephalopathy (HP:0200134)2.54380100
35Pancreatic fibrosis (HP:0100732)2.53370576
36Abnormality of the nasal septum (HP:0000419)2.50723962
37Abnormality of the corticospinal tract (HP:0002492)2.50653251
38Lower limb amyotrophy (HP:0007210)2.50018627
39Distal lower limb amyotrophy (HP:0008944)2.48797481
40Nephrogenic diabetes insipidus (HP:0009806)2.48570612
41Abnormal respiratory motile cilium physiology (HP:0012261)2.42553704
42Impaired vibration sensation in the lower limbs (HP:0002166)2.36452713
43Poor coordination (HP:0002370)2.30779099
44Limb dystonia (HP:0002451)2.30493394
45Pheochromocytoma (HP:0002666)2.30394486
46Muscle hypertrophy of the lower extremities (HP:0008968)2.29199572
47Widely spaced teeth (HP:0000687)2.27681295
48Epileptiform EEG discharges (HP:0011182)2.27215035
49Volvulus (HP:0002580)2.22526097
50Protruding tongue (HP:0010808)2.21878632
51Gaze-evoked nystagmus (HP:0000640)2.21652299
52Thyroid carcinoma (HP:0002890)2.21536442
53Submucous cleft hard palate (HP:0000176)2.20694013
54Drooling (HP:0002307)2.19780828
55Excessive salivation (HP:0003781)2.19780828
56Atonic seizures (HP:0010819)2.18938566
57EEG with generalized epileptiform discharges (HP:0011198)2.14594111
58Parakeratosis (HP:0001036)2.14451405
59Abnormality of the renal cortex (HP:0011035)2.12859496
60Abnormality of the ischium (HP:0003174)2.12377516
61Ulnar claw (HP:0001178)2.11472482
62Abnormality of the parathyroid morphology (HP:0011766)2.09634864
63Congenital sensorineural hearing impairment (HP:0008527)2.07103197
64Lip pit (HP:0100267)2.04479937
65Abnormal respiratory motile cilium morphology (HP:0005938)2.03860288
66Abnormal respiratory epithelium morphology (HP:0012253)2.03860288
67Type II lissencephaly (HP:0007260)2.02349081
68Hypsarrhythmia (HP:0002521)2.01212625
69Abnormality of DNA repair (HP:0003254)1.99164772
70Midline defect of the nose (HP:0004122)1.96810626
71Abnormality of salivation (HP:0100755)1.96556176
72Cupped ear (HP:0000378)1.96537978
73Generalized tonic-clonic seizures (HP:0002069)1.95215066
74Short foot (HP:0001773)1.95213648
75Exotropia (HP:0000577)1.94814204
76Neuroendocrine neoplasm (HP:0100634)1.94468283
77Onion bulb formation (HP:0003383)1.92499456
78Dysdiadochokinesis (HP:0002075)1.91421790
79Decreased circulating renin level (HP:0003351)1.91368279
80Large for gestational age (HP:0001520)1.91094619
81Hypoplastic labia majora (HP:0000059)1.89054288
82White forelock (HP:0002211)1.88833128
83Nephroblastoma (Wilms tumor) (HP:0002667)1.88369522
84Specific learning disability (HP:0001328)1.86752741
85Cystic liver disease (HP:0006706)1.86325143
86Decreased motor nerve conduction velocity (HP:0003431)1.84833200
87Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84512566
88Hepatoblastoma (HP:0002884)1.83328389
89Decreased central vision (HP:0007663)1.82508981
90Ectopic kidney (HP:0000086)1.82382305
91Tubulointerstitial nephritis (HP:0001970)1.82149438
92Chin dimple (HP:0010751)1.81659558
93Hyperventilation (HP:0002883)1.81609403
94Absent eyebrow (HP:0002223)1.81322700
95Duplication of thumb phalanx (HP:0009942)1.81140348
96Gastrointestinal atresia (HP:0002589)1.80546681
97Abnormality of incisor morphology (HP:0011063)1.79659637
98Hyperglycemia (HP:0003074)1.79095516
99Impaired vibratory sensation (HP:0002495)1.79058377
100Polyphagia (HP:0002591)1.77670747
101Furrowed tongue (HP:0000221)1.77481874
102Optic neuritis (HP:0100653)1.76618299
103Retrobulbar optic neuritis (HP:0100654)1.76618299
104Postaxial hand polydactyly (HP:0001162)1.76406862
105Aqueductal stenosis (HP:0002410)1.75683311
106Morphological abnormality of the pyramidal tract (HP:0002062)1.75069753
107Lower limb muscle weakness (HP:0007340)1.74611783
108Embryonal renal neoplasm (HP:0011794)1.73623050
109Inability to walk (HP:0002540)1.72803439
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.72523185
111Blue irides (HP:0000635)1.72019640
112Narrow forehead (HP:0000341)1.71742544
113Papilledema (HP:0001085)1.71659394
114Septo-optic dysplasia (HP:0100842)1.70217304
115Abnormality of the lower motor neuron (HP:0002366)1.70064997
116Decreased lacrimation (HP:0000633)1.69862443
117Abnormality of the labia majora (HP:0012881)1.69780915
118Steppage gait (HP:0003376)1.69310581
119Hemiparesis (HP:0001269)1.68413522
120Atelectasis (HP:0100750)1.68240159
121Thickened helices (HP:0000391)1.68126563
122Deeply set eye (HP:0000490)1.67808154
123Nephronophthisis (HP:0000090)1.67689806
124Hyperinsulinemic hypoglycemia (HP:0000825)1.67069066
125Tubular atrophy (HP:0000092)1.67068568
126Clubbing of toes (HP:0100760)1.66994244
127Hypoplastic ischia (HP:0003175)1.66856611
128Abnormal biliary tract morphology (HP:0012440)1.66629496
129Stomatitis (HP:0010280)1.66286277
130Abnormal eating behavior (HP:0100738)1.66039170
131Cutaneous finger syndactyly (HP:0010554)1.64371493
132Abnormal pancreas size (HP:0012094)1.64334712
133Overfolded helix (HP:0000396)1.63815662
134Absent frontal sinuses (HP:0002688)1.62697010
135Mixed hearing impairment (HP:0000410)1.62655549
136Stomach cancer (HP:0012126)1.62481739
137Patchy hypopigmentation of hair (HP:0011365)1.61947706
138Thyroiditis (HP:0100646)1.61667371
139Aplasia/Hypoplasia of the lens (HP:0008063)1.61181589
140Renal cortical cysts (HP:0000803)1.61109663
141Generalized hypopigmentation of hair (HP:0011358)1.60986392
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.60919312
143Abnormality of the axillary hair (HP:0100134)1.60798890
144Abnormality of secondary sexual hair (HP:0009888)1.60798890
145Hypothermia (HP:0002045)1.60687415
146Progressive inability to walk (HP:0002505)1.60648202
147Hemiplegia (HP:0002301)1.59934191
148Pulmonic stenosis (HP:0001642)1.59713044
149Morphological abnormality of the middle ear (HP:0008609)1.59572045
150Gastroesophageal reflux (HP:0002020)1.59510287
151Abnormality of binocular vision (HP:0011514)1.59097735
152Diplopia (HP:0000651)1.59097735
153Hypocalcemia (HP:0002901)1.58864383
154Paraplegia (HP:0010550)1.58580022
155Urinary bladder sphincter dysfunction (HP:0002839)1.58227753
156Absence seizures (HP:0002121)1.58130874
157Abnormality of the renal medulla (HP:0100957)1.58084376
158Curly hair (HP:0002212)1.57960081
159Abnormal hair whorl (HP:0010721)1.57333453
160Fair hair (HP:0002286)1.57325601
161Distal lower limb muscle weakness (HP:0009053)1.56074462
162Aplasia involving bones of the extremities (HP:0009825)1.55090679
163Aplasia involving bones of the upper limbs (HP:0009823)1.55090679
164Aplasia of the phalanges of the hand (HP:0009802)1.55090679
165Action tremor (HP:0002345)1.54032112
166Dialeptic seizures (HP:0011146)1.53748489
167Abnormality of the preputium (HP:0100587)1.53688238
168Slow saccadic eye movements (HP:0000514)1.53662231
169Optic nerve hypoplasia (HP:0000609)1.53166287
170Inappropriate behavior (HP:0000719)1.52384911
171Genetic anticipation (HP:0003743)1.52126698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.20876870
2TNIK3.15767524
3ACVR1B2.98653503
4NTRK32.92913092
5RIPK42.28936148
6WNK32.27168182
7GRK12.16448799
8SIK22.10811379
9MARK12.06693839
10CAMK1G1.93758918
11TAF11.90393896
12MAP2K71.85132952
13EPHA41.84111451
14EIF2AK21.69796320
15PKN11.67721806
16NTRK21.66107941
17MAP3K41.56304880
18INSRR1.54682092
19BLK1.52854355
20NLK1.52072707
21MAPK131.50404339
22PNCK1.49965344
23MAP4K21.46023929
24MAP3K131.44863407
25ERBB31.44707073
26PAK31.43666528
27NEK61.42314522
28FES1.39072190
29MAP3K141.37795410
30CAMKK21.37223766
31PINK11.36528549
32ZAK1.35846601
33CAMK1D1.35441160
34TXK1.30674309
35BRD41.29783019
36FGR1.24730319
37YES11.23866533
38NUAK11.16836401
39SGK21.14036286
40STK38L1.09065090
41TIE11.08854096
42WNK11.08073287
43STK391.07871860
44OBSCN1.04988703
45BMPR1B1.02067139
46FRK1.01789490
47PRKCE1.00713287
48TNK21.00474938
49BMPR21.00438250
50FGFR20.98154890
51MAP3K90.97254682
52STK240.94910485
53SGK10.94639236
54ADRBK20.93589517
55LATS10.93327969
56MARK20.91930569
57KSR10.91357186
58MKNK20.90286398
59CDK30.90232390
60SGK2230.88995945
61SGK4940.88995945
62IRAK40.87027344
63MUSK0.85231143
64PIK3CA0.84894570
65STK30.83962038
66GRK70.83353002
67PLK20.81346388
68PRPF4B0.80051403
69DMPK0.80020684
70SIK30.79636622
71MAP3K120.75916101
72IRAK10.75216339
73IRAK20.73951907
74CAMK2A0.73513170
75IRAK30.73222485
76TGFBR10.71813263
77MAP3K20.71019466
78JAK10.70199352
79PRKCQ0.69902947
80MKNK10.69405943
81CDK50.67965329
82TAOK30.67186010
83CSNK1G10.65072189
84MAP3K70.64609571
85CDK190.64606664
86CAMK10.63877312
87HCK0.63676346
88TRIM280.63321619
89PRKG10.63246050
90CSNK1A1L0.62393440
91PTK2B0.62037810
92CAMK2B0.61794488
93PHKG20.61351930
94PHKG10.61351930
95DAPK20.60864635
96OXSR10.60396266
97PIK3CG0.59507601
98PRKAA20.58144065
99TRPM70.56712946
100STK110.56261334
101SGK30.56157954
102EPHA30.54758398
103DYRK1A0.54304537
104PDGFRB0.54198136
105CDC42BPA0.53866366
106PRKCH0.53784805
107RPS6KB10.53734015
108FYN0.53319998
109MINK10.52416824
110NTRK10.52368257
111MAP3K60.50799246
112MAPK100.50220011
113FER0.48168776
114BRSK20.47103794
115PRKCG0.46937434
116BCR0.46420654
117CAMK40.46122229
118CCNB10.44725094
119AKT30.44699257
120MAPK70.43860846
121CAMK2D0.43714649
122PRKCB0.43371694
123EPHB20.43279050
124PAK60.43107903
125RET0.42452960
126CSNK1D0.42387888
127CAMKK10.42012085
128TEC0.41306776
129UHMK10.41195413
130CLK10.41050673
131FGFR10.39104234
132CSNK1G20.38733695
133MAP2K40.38303398
134FGFR30.37919093
135PRKAA10.37539313
136CDK120.37509215
137HIPK20.37507201
138ROCK10.36583972

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12731371
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.39755058
3Phototransduction_Homo sapiens_hsa047442.01418946
4Morphine addiction_Homo sapiens_hsa050322.01260761
5Glutamatergic synapse_Homo sapiens_hsa047241.95419426
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93889873
7Taste transduction_Homo sapiens_hsa047421.86137195
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72563160
9Serotonergic synapse_Homo sapiens_hsa047261.71059191
10Axon guidance_Homo sapiens_hsa043601.58000978
11Circadian entrainment_Homo sapiens_hsa047131.55081995
12Circadian rhythm_Homo sapiens_hsa047101.49983482
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49748541
14GABAergic synapse_Homo sapiens_hsa047271.49588073
15Salivary secretion_Homo sapiens_hsa049701.47049306
16Olfactory transduction_Homo sapiens_hsa047401.43242154
17Amphetamine addiction_Homo sapiens_hsa050311.41567506
18Calcium signaling pathway_Homo sapiens_hsa040201.39583577
19Dorso-ventral axis formation_Homo sapiens_hsa043201.39237782
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37930179
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37168934
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36478661
23Cholinergic synapse_Homo sapiens_hsa047251.34849229
24Long-term potentiation_Homo sapiens_hsa047201.31856258
25Renin secretion_Homo sapiens_hsa049241.30975498
26Long-term depression_Homo sapiens_hsa047301.28602867
27Dopaminergic synapse_Homo sapiens_hsa047281.24063439
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21602645
29Propanoate metabolism_Homo sapiens_hsa006401.21342410
30Gastric acid secretion_Homo sapiens_hsa049711.20859954
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20690080
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20321916
33Cocaine addiction_Homo sapiens_hsa050301.19703683
34Butanoate metabolism_Homo sapiens_hsa006501.19604760
35Insulin secretion_Homo sapiens_hsa049111.16822133
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16539986
37Synaptic vesicle cycle_Homo sapiens_hsa047211.14868463
38Type II diabetes mellitus_Homo sapiens_hsa049301.12245962
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10744247
40Sphingolipid metabolism_Homo sapiens_hsa006001.10699650
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08988324
42cAMP signaling pathway_Homo sapiens_hsa040241.07627383
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07103176
44Oxytocin signaling pathway_Homo sapiens_hsa049211.06213685
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04983517
46ErbB signaling pathway_Homo sapiens_hsa040121.02898441
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99631526
48Protein export_Homo sapiens_hsa030600.96719889
49ABC transporters_Homo sapiens_hsa020100.95619087
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95383042
51Fanconi anemia pathway_Homo sapiens_hsa034600.95181449
52Inositol phosphate metabolism_Homo sapiens_hsa005620.91334960
53Thyroid hormone synthesis_Homo sapiens_hsa049180.90287487
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89143630
55Ether lipid metabolism_Homo sapiens_hsa005650.88857800
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.88776751
57Linoleic acid metabolism_Homo sapiens_hsa005910.88433583
58Chemokine signaling pathway_Homo sapiens_hsa040620.88237453
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88149428
60Choline metabolism in cancer_Homo sapiens_hsa052310.88059823
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.87275276
62GnRH signaling pathway_Homo sapiens_hsa049120.86874523
63Asthma_Homo sapiens_hsa053100.83363392
64Ras signaling pathway_Homo sapiens_hsa040140.83001335
65Melanogenesis_Homo sapiens_hsa049160.82860317
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.82285275
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81955207
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81741293
69African trypanosomiasis_Homo sapiens_hsa051430.81349886
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80944517
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80368558
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79695812
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78160987
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77942870
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76965404
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.76581589
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76473246
78Pancreatic secretion_Homo sapiens_hsa049720.75685178
79MAPK signaling pathway_Homo sapiens_hsa040100.75444290
80Rheumatoid arthritis_Homo sapiens_hsa053230.73621996
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73520268
82Autoimmune thyroid disease_Homo sapiens_hsa053200.73122154
83T cell receptor signaling pathway_Homo sapiens_hsa046600.73089686
84Hematopoietic cell lineage_Homo sapiens_hsa046400.72833895
85Wnt signaling pathway_Homo sapiens_hsa043100.72795567
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72414091
87Collecting duct acid secretion_Homo sapiens_hsa049660.72396142
88Tight junction_Homo sapiens_hsa045300.71587675
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71571806
90Graft-versus-host disease_Homo sapiens_hsa053320.71558871
91Protein digestion and absorption_Homo sapiens_hsa049740.70835172
92Ovarian steroidogenesis_Homo sapiens_hsa049130.70716877
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68957613
94Allograft rejection_Homo sapiens_hsa053300.67382988
95TGF-beta signaling pathway_Homo sapiens_hsa043500.67150182
96Hippo signaling pathway_Homo sapiens_hsa043900.66970462
97Osteoclast differentiation_Homo sapiens_hsa043800.66825939
98Histidine metabolism_Homo sapiens_hsa003400.66397196
99Regulation of autophagy_Homo sapiens_hsa041400.66166463
100Bile secretion_Homo sapiens_hsa049760.64898474
101Estrogen signaling pathway_Homo sapiens_hsa049150.64818602
102Glioma_Homo sapiens_hsa052140.63374729
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63340100
104Nitrogen metabolism_Homo sapiens_hsa009100.62918922
105Mineral absorption_Homo sapiens_hsa049780.62643519
106Hedgehog signaling pathway_Homo sapiens_hsa043400.62061016
107Melanoma_Homo sapiens_hsa052180.61905703
108Gap junction_Homo sapiens_hsa045400.61785841
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60688092
110Dilated cardiomyopathy_Homo sapiens_hsa054140.60003129
111Glucagon signaling pathway_Homo sapiens_hsa049220.59160648
112Alcoholism_Homo sapiens_hsa050340.58190334
113Rap1 signaling pathway_Homo sapiens_hsa040150.57613403
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57522783
115Measles_Homo sapiens_hsa051620.57030931
116Basal cell carcinoma_Homo sapiens_hsa052170.55970258
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.55857099
118Prolactin signaling pathway_Homo sapiens_hsa049170.55730828
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55298015
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.54812554
121Lysine degradation_Homo sapiens_hsa003100.54594406
122B cell receptor signaling pathway_Homo sapiens_hsa046620.54075050
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53857080
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53775070
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.53739152
126Oocyte meiosis_Homo sapiens_hsa041140.53091456
127beta-Alanine metabolism_Homo sapiens_hsa004100.52870519
128Type I diabetes mellitus_Homo sapiens_hsa049400.52715552
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50361840
130mTOR signaling pathway_Homo sapiens_hsa041500.50312911
131TNF signaling pathway_Homo sapiens_hsa046680.50304111
132Non-homologous end-joining_Homo sapiens_hsa034500.49807454
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49541363
134FoxO signaling pathway_Homo sapiens_hsa040680.49184077
135Primary immunodeficiency_Homo sapiens_hsa053400.46964738
136Platelet activation_Homo sapiens_hsa046110.46765779
137ECM-receptor interaction_Homo sapiens_hsa045120.46572629
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.46053897
139Colorectal cancer_Homo sapiens_hsa052100.42413698

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