ZDHHC22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.71294135
2synaptic vesicle maturation (GO:0016188)6.36358780
3glutamate secretion (GO:0014047)6.02234569
4synaptic vesicle exocytosis (GO:0016079)5.94912449
5regulation of synaptic vesicle exocytosis (GO:2000300)5.80940848
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78903517
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.69517138
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.55159045
9vocalization behavior (GO:0071625)5.51282052
10locomotory exploration behavior (GO:0035641)5.30430665
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16268199
12regulation of synaptic vesicle transport (GO:1902803)5.08368362
13protein localization to synapse (GO:0035418)4.91119976
14neurotransmitter secretion (GO:0007269)4.84880634
15regulation of glutamate receptor signaling pathway (GO:1900449)4.83719519
16neuron cell-cell adhesion (GO:0007158)4.81314621
17L-amino acid import (GO:0043092)4.80885406
18neuronal action potential propagation (GO:0019227)4.71507420
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.56044475
20amino acid import (GO:0043090)4.44027285
21neurotransmitter-gated ion channel clustering (GO:0072578)4.42716289
22proline transport (GO:0015824)4.31907731
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.27276489
24cellular potassium ion homeostasis (GO:0030007)4.25584981
25regulation of neuronal synaptic plasticity (GO:0048168)4.22769539
26exploration behavior (GO:0035640)4.17121420
27layer formation in cerebral cortex (GO:0021819)4.12623201
28neuromuscular process controlling posture (GO:0050884)4.09183208
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07870838
30gamma-aminobutyric acid transport (GO:0015812)4.03430382
31synaptic transmission, glutamatergic (GO:0035249)4.00764683
32neurotransmitter transport (GO:0006836)3.98471764
33cerebellar granule cell differentiation (GO:0021707)3.88420573
34neuron-neuron synaptic transmission (GO:0007270)3.86431926
35positive regulation of membrane potential (GO:0045838)3.83129703
36glutamate receptor signaling pathway (GO:0007215)3.82140860
37central nervous system myelination (GO:0022010)3.80173590
38axon ensheathment in central nervous system (GO:0032291)3.80173590
39long-term memory (GO:0007616)3.79449462
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75153178
41cerebellar Purkinje cell differentiation (GO:0021702)3.71674685
42neurotransmitter uptake (GO:0001504)3.66122852
43regulation of neurotransmitter secretion (GO:0046928)3.65014818
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64307221
45activation of protein kinase A activity (GO:0034199)3.64073323
46acidic amino acid transport (GO:0015800)3.62813394
47regulation of neurotransmitter levels (GO:0001505)3.62551700
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60976794
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59858794
50regulation of synapse structural plasticity (GO:0051823)3.59655229
51establishment of mitochondrion localization (GO:0051654)3.58821668
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56631068
53potassium ion import (GO:0010107)3.54865724
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54843184
55regulation of postsynaptic membrane potential (GO:0060078)3.53134702
56response to auditory stimulus (GO:0010996)3.51773093
57sodium ion export (GO:0071436)3.49738809
58postsynaptic membrane organization (GO:0001941)3.47483957
59positive regulation of synapse maturation (GO:0090129)3.47115863
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47084183
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.45724988
62synaptic vesicle endocytosis (GO:0048488)3.45183710
63positive regulation of neurotransmitter transport (GO:0051590)3.43829007
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42085373
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.41447533
66regulation of synaptic plasticity (GO:0048167)3.41119117
67regulation of neurotransmitter transport (GO:0051588)3.38438142
68long-term synaptic potentiation (GO:0060291)3.37494266
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37355579
70dendritic spine morphogenesis (GO:0060997)3.36389490
71auditory behavior (GO:0031223)3.34877377
72regulation of vesicle fusion (GO:0031338)3.34871197
73neuronal ion channel clustering (GO:0045161)3.29248349
74positive regulation of neurotransmitter secretion (GO:0001956)3.28934165
75positive regulation of dendritic spine development (GO:0060999)3.28599839
76neuron recognition (GO:0008038)3.27292655
77L-glutamate transport (GO:0015813)3.26859312
78presynaptic membrane assembly (GO:0097105)3.25041559
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23053339
80membrane depolarization during action potential (GO:0086010)3.22043923
81pyrimidine nucleobase catabolic process (GO:0006208)3.21724026
82cerebellar Purkinje cell layer development (GO:0021680)3.21400976
83mechanosensory behavior (GO:0007638)3.21073137
84positive regulation of synaptic transmission (GO:0050806)3.20545136
85glycine transport (GO:0015816)3.15226356
86neuromuscular process controlling balance (GO:0050885)3.14481383
87negative regulation of dendrite morphogenesis (GO:0050774)3.14150965
88vesicle transport along microtubule (GO:0047496)3.13688956
89membrane hyperpolarization (GO:0060081)3.13190128
90cell migration in hindbrain (GO:0021535)3.12402484
91presynaptic membrane organization (GO:0097090)3.11423125
92cell communication by electrical coupling (GO:0010644)3.10329020
93response to histamine (GO:0034776)3.09526393
94transmission of nerve impulse (GO:0019226)3.08423218
95membrane depolarization (GO:0051899)3.08045170
96regulation of synaptic transmission (GO:0050804)3.04535165
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03567264
98synaptic transmission (GO:0007268)3.02795778
99synapse assembly (GO:0007416)3.01360412
100neuromuscular synaptic transmission (GO:0007274)3.01193856
101calcium ion-dependent exocytosis (GO:0017156)3.01125458
102positive regulation of potassium ion transmembrane transport (GO:1901381)3.00634984
103axonal fasciculation (GO:0007413)2.97915731
104regulation of dendritic spine morphogenesis (GO:0061001)2.97824328
105intraspecies interaction between organisms (GO:0051703)2.97062282
106social behavior (GO:0035176)2.97062282
107learning (GO:0007612)2.95434709
108adult walking behavior (GO:0007628)2.94654893
109regulation of synaptic transmission, GABAergic (GO:0032228)2.94644500
110regulation of neurotransmitter uptake (GO:0051580)2.93788547
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93168724
112behavioral response to cocaine (GO:0048148)2.92841393
113regulation of voltage-gated calcium channel activity (GO:1901385)2.92761372
114potassium ion homeostasis (GO:0055075)2.92315488
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91099281
116startle response (GO:0001964)2.90905806
117innervation (GO:0060384)2.90796375
118neuromuscular process (GO:0050905)2.89714630
119cellular sodium ion homeostasis (GO:0006883)2.87606376
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.86910773
121mitochondrion transport along microtubule (GO:0047497)2.85748547
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85748547
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.83709369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76445200
2GBX2_23144817_ChIP-Seq_PC3_Human3.77751178
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14056887
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04295752
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92085531
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.91759489
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63104413
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63104413
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56573811
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55448651
11DROSHA_22980978_ChIP-Seq_HELA_Human2.54403056
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.53862121
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53069967
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48642529
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48511864
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.46230775
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44315013
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.36974158
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32038550
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30825911
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27001388
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23270672
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.22413732
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12537319
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.10745816
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01867135
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99038421
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97464932
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88368167
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85979483
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85803739
32TAF15_26573619_Chip-Seq_HEK293_Human1.85020592
33AR_21572438_ChIP-Seq_LNCaP_Human1.73300019
34SMAD4_21799915_ChIP-Seq_A2780_Human1.71486747
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64601174
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60960229
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.56771971
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.56330857
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47976053
40* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39622368
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39385833
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37849370
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37834641
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36323294
45* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36293983
46P300_19829295_ChIP-Seq_ESCs_Human1.34801777
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.34638380
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33023930
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32211793
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31959652
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28771696
52ZNF274_21170338_ChIP-Seq_K562_Hela1.27489220
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26688971
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26443643
55AR_25329375_ChIP-Seq_VCAP_Human1.25730686
56STAT3_23295773_ChIP-Seq_U87_Human1.25527854
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.25391604
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.24000720
59AR_19668381_ChIP-Seq_PC3_Human1.22928618
60* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22711567
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.20873952
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18922856
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17907015
64* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17283148
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15077965
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14599383
67TCF4_23295773_ChIP-Seq_U87_Human1.12432296
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12417339
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10253385
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09934928
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09760802
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09588893
73* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08191497
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07224328
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06857784
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.05779701
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05452310
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04823615
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04299023
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04023355
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04023355
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03794932
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.03676660
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03335224
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02025222
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01738500
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01348470
88AHR_22903824_ChIP-Seq_MCF-7_Human1.01312578
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00938833
90SOX9_26525672_Chip-Seq_HEART_Mouse1.00751389
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00513954
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00446268
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99301586
94KDM2B_26808549_Chip-Seq_K562_Human0.97887031
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97193135
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.96675758
97RNF2_27304074_Chip-Seq_NSC_Mouse0.96454548
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96219581
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95572528
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95073187
101RING1B_27294783_Chip-Seq_NPCs_Mouse0.94952151
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.94868849
103RUNX2_22187159_ChIP-Seq_PCA_Human0.91395393
104RXR_22108803_ChIP-Seq_LS180_Human0.91361193
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91094450
106IGF1R_20145208_ChIP-Seq_DFB_Human0.90609707
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90329083
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90015567
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.89617410
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89104005
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88693407
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87188851
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86884911
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86300022
115JUN_21703547_ChIP-Seq_K562_Human0.86249196
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85926150
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.85414595
118POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.83789981
119* CTCF_27219007_Chip-Seq_Bcells_Human0.83569161
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.83307232
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82597981
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81910668
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81812735
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.80410497
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80313463
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79688258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90987320
2MP0003880_abnormal_central_pattern5.12495815
3MP0003635_abnormal_synaptic_transmissio4.01743452
4MP0004270_analgesia3.71204887
5MP0009745_abnormal_behavioral_response3.35142024
6MP0009046_muscle_twitch3.34574795
7MP0002064_seizures3.23771266
8MP0001968_abnormal_touch/_nociception3.14775505
9MP0002063_abnormal_learning/memory/cond3.09989387
10MP0005423_abnormal_somatic_nervous2.92368565
11MP0002822_catalepsy2.82885827
12MP0002734_abnormal_mechanical_nocicepti2.75667734
13MP0002572_abnormal_emotion/affect_behav2.73340609
14MP0002272_abnormal_nervous_system2.62798876
15MP0001501_abnormal_sleep_pattern2.50003102
16MP0001486_abnormal_startle_reflex2.40565873
17MP0006276_abnormal_autonomic_nervous2.40546626
18MP0002735_abnormal_chemical_nociception2.39566542
19MP0002736_abnormal_nociception_after2.34273082
20MP0009780_abnormal_chondrocyte_physiolo2.24284586
21MP0002733_abnormal_thermal_nociception2.13470701
22MP0001440_abnormal_grooming_behavior2.05319803
23MP0001970_abnormal_pain_threshold2.04844034
24MP0002067_abnormal_sensory_capabilities2.00139569
25MP0005646_abnormal_pituitary_gland1.97809938
26MP0002909_abnormal_adrenal_gland1.94468461
27MP0004858_abnormal_nervous_system1.94243509
28MP0003879_abnormal_hair_cell1.88113243
29MP0003122_maternal_imprinting1.86881035
30MP0004924_abnormal_behavior1.79419223
31MP0005386_behavior/neurological_phenoty1.79419223
32MP0008569_lethality_at_weaning1.77517380
33MP0004811_abnormal_neuron_physiology1.76296802
34MP0005645_abnormal_hypothalamus_physiol1.75895263
35MP0002184_abnormal_innervation1.72397344
36MP0002557_abnormal_social/conspecific_i1.70931699
37MP0001984_abnormal_olfaction1.69647188
38MP0003329_amyloid_beta_deposits1.63184894
39MP0003787_abnormal_imprinting1.62133486
40MP0008877_abnormal_DNA_methylation1.59275083
41MP0001502_abnormal_circadian_rhythm1.51196466
42MP0000955_abnormal_spinal_cord1.44629239
43MP0000778_abnormal_nervous_system1.44369455
44MP0010386_abnormal_urinary_bladder1.43047056
45MP0003633_abnormal_nervous_system1.41435447
46MP0002653_abnormal_ependyma_morphology1.38744370
47MP0002882_abnormal_neuron_morphology1.37793741
48MP0002066_abnormal_motor_capabilities/c1.37718227
49MP0004142_abnormal_muscle_tone1.35911526
50MP0003136_yellow_coat_color1.32085291
51MP0001529_abnormal_vocalization1.31420331
52MP0001905_abnormal_dopamine_level1.24048094
53MP0004885_abnormal_endolymph1.22734599
54MP0005551_abnormal_eye_electrophysiolog1.22147290
55MP0003631_nervous_system_phenotype1.12665660
56MP0002229_neurodegeneration1.12663340
57MP0000751_myopathy1.12316254
58MP0008872_abnormal_physiological_respon1.07671563
59MP0003861_abnormal_nervous_system1.04380668
60MP0003283_abnormal_digestive_organ1.03506484
61MP0000013_abnormal_adipose_tissue1.03197125
62MP0000579_abnormal_nail_morphology1.01587046
63MP0004742_abnormal_vestibular_system0.96783063
64MP0002152_abnormal_brain_morphology0.94995678
65MP0002069_abnormal_eating/drinking_beha0.93105153
66MP0004133_heterotaxia0.92583192
67MP0001188_hyperpigmentation0.92240839
68MP0005535_abnormal_body_temperature0.91970559
69MP0004145_abnormal_muscle_electrophysio0.91712277
70MP0001299_abnormal_eye_distance/0.91347399
71MP0004043_abnormal_pH_regulation0.88667635
72MP0009672_abnormal_birth_weight0.86926981
73MP0004085_abnormal_heartbeat0.84621776
74MP0003690_abnormal_glial_cell0.84373088
75MP0001177_atelectasis0.84155348
76MP0008874_decreased_physiological_sensi0.83661640
77MP0002837_dystrophic_cardiac_calcinosis0.83164448
78MP0003890_abnormal_embryonic-extraembry0.81841827
79MP0001963_abnormal_hearing_physiology0.79624492
80MP0003634_abnormal_glial_cell0.78554373
81MP0003119_abnormal_digestive_system0.78305829
82MP0000026_abnormal_inner_ear0.77672236
83MP0003123_paternal_imprinting0.77073319
84MP0000631_abnormal_neuroendocrine_gland0.75425809
85MP0005394_taste/olfaction_phenotype0.74515457
86MP0005499_abnormal_olfactory_system0.74515457
87MP0002638_abnormal_pupillary_reflex0.74407549
88MP0002751_abnormal_autonomic_nervous0.74387854
89MP0008961_abnormal_basal_metabolism0.73942249
90MP0000569_abnormal_digit_pigmentation0.73759503
91MP0006292_abnormal_olfactory_placode0.73360713
92MP0002752_abnormal_somatic_nervous0.72556827
93MP0002876_abnormal_thyroid_physiology0.71451744
94MP0003075_altered_response_to0.69736107
95MP0003938_abnormal_ear_development0.69619746
96MP0003632_abnormal_nervous_system0.68933031
97MP0004233_abnormal_muscle_weight0.68573520
98MP0000604_amyloidosis0.68429205
99MP0006072_abnormal_retinal_apoptosis0.68140855
100MP0001346_abnormal_lacrimal_gland0.68098435
101MP0001664_abnormal_digestion0.67800504
102MP0002102_abnormal_ear_morphology0.67598532
103MP0002090_abnormal_vision0.67158401
104MP0001485_abnormal_pinna_reflex0.66405970
105MP0000920_abnormal_myelination0.66345340
106MP0000566_synostosis0.65089100
107MP0001986_abnormal_taste_sensitivity0.64730803
108MP0002082_postnatal_lethality0.64014206
109MP0010770_preweaning_lethality0.64014206
110MP0010768_mortality/aging0.63707866
111MP0003172_abnormal_lysosome_physiology0.63413194
112MP0005253_abnormal_eye_physiology0.61777351
113MP0005167_abnormal_blood-brain_barrier0.61681295
114MP0002081_perinatal_lethality0.60968561
115MP0005623_abnormal_meninges_morphology0.58585431
116MP0003137_abnormal_impulse_conducting0.57213275
117MP0001293_anophthalmia0.56953541
118MP0001943_abnormal_respiration0.56828378
119MP0004215_abnormal_myocardial_fiber0.55522435
120MP0003121_genomic_imprinting0.53433976
121MP0003183_abnormal_peptide_metabolism0.52981993
122MP0004484_altered_response_of0.51300216
123MP0010769_abnormal_survival0.50392199

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65788463
2Myokymia (HP:0002411)6.42645179
3Focal seizures (HP:0007359)5.83098483
4Visual hallucinations (HP:0002367)5.28913496
5Epileptic encephalopathy (HP:0200134)5.00210720
6Atonic seizures (HP:0010819)4.96758793
7Febrile seizures (HP:0002373)4.49965298
8Absence seizures (HP:0002121)4.47410772
9Progressive cerebellar ataxia (HP:0002073)4.46213337
10Generalized tonic-clonic seizures (HP:0002069)4.23770011
11Dialeptic seizures (HP:0011146)3.99995144
12Action tremor (HP:0002345)3.70681348
13Ankle clonus (HP:0011448)3.70590465
14Supranuclear gaze palsy (HP:0000605)3.67689119
15Depression (HP:0000716)3.44125196
16Urinary bladder sphincter dysfunction (HP:0002839)3.42270230
17Hyperventilation (HP:0002883)3.41061541
18Broad-based gait (HP:0002136)3.36764550
19Postural instability (HP:0002172)3.36108164
20Truncal ataxia (HP:0002078)3.28954360
21Impaired vibration sensation in the lower limbs (HP:0002166)3.23936185
22Abnormal eating behavior (HP:0100738)3.23478850
23Gaze-evoked nystagmus (HP:0000640)3.19121726
24Anxiety (HP:0000739)3.18900445
25Dysdiadochokinesis (HP:0002075)3.16814530
26Poor eye contact (HP:0000817)3.11329068
27Pheochromocytoma (HP:0002666)3.10957489
28Abnormality of the labia minora (HP:0012880)3.01638534
29Papilledema (HP:0001085)2.94179116
30Peripheral hypomyelination (HP:0007182)2.92875052
31Genetic anticipation (HP:0003743)2.90412014
32Dysmetria (HP:0001310)2.89358897
33Abnormal social behavior (HP:0012433)2.88635462
34Impaired social interactions (HP:0000735)2.88635462
35Amblyopia (HP:0000646)2.79687184
36Spastic gait (HP:0002064)2.79183488
37Split foot (HP:0001839)2.77234868
38Mutism (HP:0002300)2.75479179
39Scanning speech (HP:0002168)2.75079787
40Neuroendocrine neoplasm (HP:0100634)2.71477160
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.71471266
42Cerebral hypomyelination (HP:0006808)2.71092148
43Bradykinesia (HP:0002067)2.69937393
44Ventricular fibrillation (HP:0001663)2.68863713
45Urinary urgency (HP:0000012)2.68422280
46Epileptiform EEG discharges (HP:0011182)2.68042003
47Sleep apnea (HP:0010535)2.66263719
48Impaired smooth pursuit (HP:0007772)2.64082946
49Progressive inability to walk (HP:0002505)2.61682680
50Hemiplegia (HP:0002301)2.60557499
51EEG with generalized epileptiform discharges (HP:0011198)2.57387412
52Torticollis (HP:0000473)2.56660411
53Excessive salivation (HP:0003781)2.53954267
54Drooling (HP:0002307)2.53954267
55Septo-optic dysplasia (HP:0100842)2.53747465
56Agitation (HP:0000713)2.51500757
57Polyphagia (HP:0002591)2.48476351
58Lower limb muscle weakness (HP:0007340)2.47327138
59Insidious onset (HP:0003587)2.47173825
60Termporal pattern (HP:0011008)2.47173825
61Abnormality of the lower motor neuron (HP:0002366)2.44131382
62Failure to thrive in infancy (HP:0001531)2.38411740
63Focal dystonia (HP:0004373)2.35813313
64Abnormality of ocular smooth pursuit (HP:0000617)2.35680662
65Abnormality of the corticospinal tract (HP:0002492)2.33143600
66Status epilepticus (HP:0002133)2.32787465
67Hypsarrhythmia (HP:0002521)2.31357543
68Hemiparesis (HP:0001269)2.28839547
69Dysmetric saccades (HP:0000641)2.28404842
70Neurofibrillary tangles (HP:0002185)2.27922284
71Annular pancreas (HP:0001734)2.27716127
72Intention tremor (HP:0002080)2.22842312
73Impaired vibratory sensation (HP:0002495)2.19906042
74Inability to walk (HP:0002540)2.18952000
75Abnormality of binocular vision (HP:0011514)2.18682671
76Diplopia (HP:0000651)2.18682671
77Craniofacial dystonia (HP:0012179)2.16660379
78Limb dystonia (HP:0002451)2.14121949
79Spastic tetraparesis (HP:0001285)2.13847279
80Obstructive sleep apnea (HP:0002870)2.13804994
81Cerebral inclusion bodies (HP:0100314)2.13042729
82Tetraplegia (HP:0002445)2.12429134
83Cortical dysplasia (HP:0002539)2.10797420
84Stereotypic behavior (HP:0000733)2.10540142
85Fetal akinesia sequence (HP:0001989)2.10244335
86Absent speech (HP:0001344)2.10223586
87Hypoventilation (HP:0002791)2.08512341
88Psychosis (HP:0000709)2.07453605
89Generalized myoclonic seizures (HP:0002123)2.07399918
90Blue irides (HP:0000635)2.07350793
91Clonus (HP:0002169)2.06654979
92Rigidity (HP:0002063)2.01833555
93Poor suck (HP:0002033)2.00121131
94Increased circulating renin level (HP:0000848)2.00120040
95Amyotrophic lateral sclerosis (HP:0007354)1.98866562
96Menstrual irregularities (HP:0000858)1.95747185
97Hypercortisolism (HP:0001578)1.93852522
98Abnormal EKG (HP:0003115)1.93674077
99CNS hypomyelination (HP:0003429)1.93453998
100Hyperthyroidism (HP:0000836)1.92375685
101Specific learning disability (HP:0001328)1.92345672
102Delusions (HP:0000746)1.91723289
103Gait ataxia (HP:0002066)1.91424439
104Resting tremor (HP:0002322)1.90672474
105Gait imbalance (HP:0002141)1.89905594
106Impaired pain sensation (HP:0007328)1.89680171
107Abnormality of pain sensation (HP:0010832)1.89680171
108Choanal stenosis (HP:0000452)1.87948306
109Insomnia (HP:0100785)1.87700181
110Optic nerve hypoplasia (HP:0000609)1.87433116
111Abnormality of saccadic eye movements (HP:0000570)1.86669420
112Incomplete penetrance (HP:0003829)1.86265516
113Apathy (HP:0000741)1.85383492
114Hepatoblastoma (HP:0002884)1.85154589
115Akinesia (HP:0002304)1.82675475
116Megalencephaly (HP:0001355)1.82408601
117Spastic tetraplegia (HP:0002510)1.81741470
118Central scotoma (HP:0000603)1.80950405
119Abnormal hair whorl (HP:0010721)1.80940494
120Postural tremor (HP:0002174)1.79854063
121Protruding tongue (HP:0010808)1.79703322
122Esophageal atresia (HP:0002032)1.79510691
123Morphological abnormality of the inner ear (HP:0011390)1.78273893
124Oligodactyly (hands) (HP:0001180)1.78204802
125Intestinal atresia (HP:0011100)1.76765871
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.75925184
127Neuronal loss in central nervous system (HP:0002529)1.72642718
128Turricephaly (HP:0000262)1.71866422
129Morphological abnormality of the pyramidal tract (HP:0002062)1.70773809
130Anomalous pulmonary venous return (HP:0010772)1.70564014
131Absent septum pellucidum (HP:0001331)1.68638525
132Esotropia (HP:0000565)1.68114888
133Hypoplasia of the corpus callosum (HP:0002079)1.66201467
134Choreoathetosis (HP:0001266)1.65453765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.60114303
2MAP3K93.54930810
3EPHA43.45731662
4MAP3K43.34681931
5CASK3.09156254
6MAP3K122.87619268
7DAPK22.76676400
8MAP2K72.74972946
9MINK12.69947674
10NTRK12.49446530
11MARK12.35812750
12PAK62.27714901
13NTRK22.16739188
14MAP2K42.10677812
15PRKD31.96786071
16CAMKK11.81480736
17DAPK11.77829105
18CDK191.70972171
19RIPK41.65691950
20DYRK21.62447798
21KSR21.61473930
22STK381.53172063
23CDK51.52744283
24GRK51.50808959
25PLK21.48817509
26UHMK11.36298933
27TNIK1.34666542
28SIK21.31864952
29PRPF4B1.29636125
30MAPK131.28018583
31SGK2231.27427467
32SGK4941.27427467
33PRKCG1.23285042
34PKN11.20124715
35TSSK61.18438940
36SGK21.15421313
37CAMKK21.15356284
38AKT31.12371798
39FES1.11780669
40PRKCH1.11717951
41KSR11.08971317
42SGK31.01948327
43MAP3K20.97069807
44OXSR10.95590925
45NEK10.94869481
46LATS20.94508880
47CAMK2A0.94318047
48CDC70.92099247
49CAMK10.91583085
50PLK30.91323570
51CSNK1G10.90938290
52CSNK1G30.90608194
53CDK180.89453008
54SIK30.87284728
55TNK20.86773327
56FGFR20.86688723
57CDK150.85626133
58CDK140.83849067
59LMTK20.82740776
60CCNB10.82077110
61CSNK1A1L0.81537638
62PHKG10.81271618
63PHKG20.81271618
64TYRO30.80255021
65TAOK10.79826853
66PAK30.79757143
67ARAF0.78522085
68STK110.76623868
69PINK10.76380714
70ALK0.76069746
71PNCK0.75757075
72RET0.72937940
73MKNK20.72242507
74CDK11A0.72222585
75CDC42BPA0.68066736
76SCYL20.68061688
77CSNK1G20.67382211
78SRPK10.67178846
79CAMK2B0.66483036
80MAP3K10.65841480
81CSNK1E0.64872920
82FER0.64513371
83INSRR0.63892441
84SGK10.63507291
85CAMK1D0.61847389
86PDK10.58381613
87TTK0.58351777
88MARK20.57027793
89BRSK10.55576303
90CDK30.54705943
91PDPK10.53709870
92MAP3K130.52910513
93MKNK10.52549245
94PRKCE0.51904373
95RPS6KA30.51717355
96CSNK1D0.51104822
97CAMK2D0.50581842
98WNK30.50290389
99DAPK30.50266941
100PRKDC0.50131687
101ERBB20.49710175
102CAMK40.48449246
103CAMK2G0.46501490
104DYRK1A0.46453173
105LIMK10.46028439
106CSNK1A10.44990276
107ZAK0.43758214
108MAP3K70.43656482
109STK38L0.42581894
110MAPK100.42407572
111WNK10.42343324
112BMPR20.42221106
113RIPK10.41029820
114PRKCZ0.40762975
115TRIM280.40523857
116BUB10.39831366
117GSK3B0.38480901
118NEK60.38139798
119FYN0.37937989
120MAP2K10.36596501
121CAMK1G0.36498009
122PRKCB0.36434894
123PTK2B0.36183046
124PLK10.34783875
125RPS6KA20.34036436
126BRAF0.32961952
127PRKCA0.30467584
128BCR0.30442541
129ROCK20.30102285
130PRKG10.29818873

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.17976664
2Nicotine addiction_Homo sapiens_hsa050333.80185809
3GABAergic synapse_Homo sapiens_hsa047272.87094416
4Olfactory transduction_Homo sapiens_hsa047402.71974361
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63807049
6Circadian entrainment_Homo sapiens_hsa047132.61443924
7Morphine addiction_Homo sapiens_hsa050322.53052272
8Glutamatergic synapse_Homo sapiens_hsa047242.39678590
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36020001
10Amphetamine addiction_Homo sapiens_hsa050312.33135287
11Long-term potentiation_Homo sapiens_hsa047202.32604250
12Insulin secretion_Homo sapiens_hsa049112.32586606
13Dopaminergic synapse_Homo sapiens_hsa047282.10083968
14Salivary secretion_Homo sapiens_hsa049702.10057255
15Collecting duct acid secretion_Homo sapiens_hsa049662.06600000
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91315849
17Taste transduction_Homo sapiens_hsa047421.89053142
18Vitamin B6 metabolism_Homo sapiens_hsa007501.83552471
19Cholinergic synapse_Homo sapiens_hsa047251.83035672
20Gastric acid secretion_Homo sapiens_hsa049711.82905764
21Cocaine addiction_Homo sapiens_hsa050301.73415838
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73305676
23Serotonergic synapse_Homo sapiens_hsa047261.63406330
24Renin secretion_Homo sapiens_hsa049241.59247029
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58209468
26Long-term depression_Homo sapiens_hsa047301.48786096
27Vibrio cholerae infection_Homo sapiens_hsa051101.47382515
28Calcium signaling pathway_Homo sapiens_hsa040201.45069862
29Oxytocin signaling pathway_Homo sapiens_hsa049211.44804204
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40610755
31Type II diabetes mellitus_Homo sapiens_hsa049301.31362028
32GnRH signaling pathway_Homo sapiens_hsa049121.28545993
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27255316
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24259114
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24016119
36Gap junction_Homo sapiens_hsa045401.19026169
37cAMP signaling pathway_Homo sapiens_hsa040241.18021977
38Phototransduction_Homo sapiens_hsa047441.13515878
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10072286
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07611675
41Estrogen signaling pathway_Homo sapiens_hsa049151.07133618
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05444994
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00765142
44Glioma_Homo sapiens_hsa052140.96786809
45Cardiac muscle contraction_Homo sapiens_hsa042600.95264979
46Nitrogen metabolism_Homo sapiens_hsa009100.92392386
47ErbB signaling pathway_Homo sapiens_hsa040120.91441464
48Melanogenesis_Homo sapiens_hsa049160.90607959
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86381570
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.83775623
51Axon guidance_Homo sapiens_hsa043600.83086215
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81266761
53Type I diabetes mellitus_Homo sapiens_hsa049400.80594928
54Pancreatic secretion_Homo sapiens_hsa049720.79408339
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78471442
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77829346
57Oocyte meiosis_Homo sapiens_hsa041140.74211429
58Hippo signaling pathway_Homo sapiens_hsa043900.73254424
59Dilated cardiomyopathy_Homo sapiens_hsa054140.69391109
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68492284
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.67985523
62Dorso-ventral axis formation_Homo sapiens_hsa043200.67602852
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67124887
64MAPK signaling pathway_Homo sapiens_hsa040100.66510555
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65054509
66Parkinsons disease_Homo sapiens_hsa050120.64938405
67Arginine and proline metabolism_Homo sapiens_hsa003300.64703820
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64553843
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62856256
70beta-Alanine metabolism_Homo sapiens_hsa004100.61900522
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60483802
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.59651772
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58545843
74Glucagon signaling pathway_Homo sapiens_hsa049220.57705959
75Circadian rhythm_Homo sapiens_hsa047100.57693898
76Tight junction_Homo sapiens_hsa045300.56592214
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56480505
78Bile secretion_Homo sapiens_hsa049760.54620401
79mRNA surveillance pathway_Homo sapiens_hsa030150.50983244
80Ras signaling pathway_Homo sapiens_hsa040140.50605762
81Alcoholism_Homo sapiens_hsa050340.50313116
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48726940
83Endocytosis_Homo sapiens_hsa041440.48394313
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48303545
85Inositol phosphate metabolism_Homo sapiens_hsa005620.47908803
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47092842
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45942945
88Choline metabolism in cancer_Homo sapiens_hsa052310.45828101
89Butanoate metabolism_Homo sapiens_hsa006500.45402799
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44945251
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43941274
92Insulin signaling pathway_Homo sapiens_hsa049100.43367774
93Fatty acid metabolism_Homo sapiens_hsa012120.42133990
94Biosynthesis of amino acids_Homo sapiens_hsa012300.41882162
95Huntingtons disease_Homo sapiens_hsa050160.41759535
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41599719
97Prion diseases_Homo sapiens_hsa050200.40918213
98mTOR signaling pathway_Homo sapiens_hsa041500.39695562
99Rap1 signaling pathway_Homo sapiens_hsa040150.39222893
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.38869635
101Ovarian steroidogenesis_Homo sapiens_hsa049130.38651055
102Rheumatoid arthritis_Homo sapiens_hsa053230.37259563
103Fatty acid biosynthesis_Homo sapiens_hsa000610.35876603
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35598022
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34868458
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34684464
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34543386
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34001539
109Arginine biosynthesis_Homo sapiens_hsa002200.33677379
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33447838
111Alzheimers disease_Homo sapiens_hsa050100.32177184
112AMPK signaling pathway_Homo sapiens_hsa041520.32064785
113Phagosome_Homo sapiens_hsa041450.31355949
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.30262148
115Steroid biosynthesis_Homo sapiens_hsa001000.29895655
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28912444
117Propanoate metabolism_Homo sapiens_hsa006400.28089100
118Wnt signaling pathway_Homo sapiens_hsa043100.28029365
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.27312653
120Endometrial cancer_Homo sapiens_hsa052130.27171870
121VEGF signaling pathway_Homo sapiens_hsa043700.26705418
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26149905
123Histidine metabolism_Homo sapiens_hsa003400.25732162
124Oxidative phosphorylation_Homo sapiens_hsa001900.25021871

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