ZDHHC24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.20030699
2polyketide metabolic process (GO:0030638)8.20030699
3doxorubicin metabolic process (GO:0044598)8.20030699
4behavioral response to nicotine (GO:0035095)6.14484811
5aminoglycoside antibiotic metabolic process (GO:0030647)5.26271402
6fucose catabolic process (GO:0019317)5.10909861
7L-fucose metabolic process (GO:0042354)5.10909861
8L-fucose catabolic process (GO:0042355)5.10909861
9regulation of female gonad development (GO:2000194)4.39201847
10tryptophan catabolic process (GO:0006569)4.16259277
11indole-containing compound catabolic process (GO:0042436)4.16259277
12indolalkylamine catabolic process (GO:0046218)4.16259277
13kynurenine metabolic process (GO:0070189)4.02400941
14synaptic vesicle maturation (GO:0016188)3.83432789
15preassembly of GPI anchor in ER membrane (GO:0016254)3.72463347
16negative regulation of telomere maintenance (GO:0032205)3.70696905
17protein complex biogenesis (GO:0070271)3.69056535
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67450125
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.67450125
20NADH dehydrogenase complex assembly (GO:0010257)3.67450125
21positive regulation of prostaglandin secretion (GO:0032308)3.67232255
22indolalkylamine metabolic process (GO:0006586)3.66773881
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.66001660
24tryptophan metabolic process (GO:0006568)3.63547961
25cellular potassium ion homeostasis (GO:0030007)3.62536797
26mannosylation (GO:0097502)3.60163122
27negative regulation of meiosis (GO:0045835)3.59761515
28cellular response to ATP (GO:0071318)3.56416619
29cellular response to exogenous dsRNA (GO:0071360)3.56325709
30respiratory chain complex IV assembly (GO:0008535)3.54859761
31mitochondrial respiratory chain complex assembly (GO:0033108)3.44554122
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44538764
33positive regulation of defense response to virus by host (GO:0002230)3.43028367
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.42949611
35positive regulation of fatty acid transport (GO:2000193)3.42780153
36cytochrome complex assembly (GO:0017004)3.42401991
37fucosylation (GO:0036065)3.39425411
38regulation of synaptic vesicle exocytosis (GO:2000300)3.36049283
39synaptic vesicle exocytosis (GO:0016079)3.27874041
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27596548
41locomotory exploration behavior (GO:0035641)3.26657232
42cellular ketone body metabolic process (GO:0046950)3.25376679
43protein import into peroxisome matrix (GO:0016558)3.19362909
44platelet dense granule organization (GO:0060155)3.18765230
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.17996139
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16889459
47cornea development in camera-type eye (GO:0061303)3.15978699
48regulation of meiosis (GO:0040020)3.15657570
49regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.13149019
50autophagic vacuole fusion (GO:0000046)3.09327173
51basic amino acid transport (GO:0015802)3.07801812
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.07649574
53positive regulation of icosanoid secretion (GO:0032305)3.05365571
54water-soluble vitamin biosynthetic process (GO:0042364)3.05218580
55detection of light stimulus involved in visual perception (GO:0050908)3.04842514
56detection of light stimulus involved in sensory perception (GO:0050962)3.04842514
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04360948
58regulation of acrosome reaction (GO:0060046)3.02774447
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99192884
60cellular biogenic amine catabolic process (GO:0042402)2.98661063
61amine catabolic process (GO:0009310)2.98661063
62purinergic nucleotide receptor signaling pathway (GO:0035590)2.95316801
63regulation of synaptic vesicle transport (GO:1902803)2.94803937
64protein-cofactor linkage (GO:0018065)2.94744157
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94301317
66nonmotile primary cilium assembly (GO:0035058)2.93693322
67response to pheromone (GO:0019236)2.91276363
68ubiquinone biosynthetic process (GO:0006744)2.91188475
69negative regulation of mast cell activation (GO:0033004)2.91179448
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90861798
71ATP synthesis coupled proton transport (GO:0015986)2.89918156
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89918156
73positive regulation of neurotransmitter secretion (GO:0001956)2.89614252
74female gamete generation (GO:0007292)2.88677985
75ketone body metabolic process (GO:1902224)2.88112263
76NAD biosynthetic process (GO:0009435)2.88071616
77neuronal action potential propagation (GO:0019227)2.86043804
78indole-containing compound metabolic process (GO:0042430)2.85072362
79base-excision repair, AP site formation (GO:0006285)2.84757860
80GPI anchor metabolic process (GO:0006505)2.84262496
81magnesium ion transport (GO:0015693)2.84207529
82negative regulation of meiotic cell cycle (GO:0051447)2.82508380
83pseudouridine synthesis (GO:0001522)2.82186948
84endosome to melanosome transport (GO:0035646)2.81317175
85endosome to pigment granule transport (GO:0043485)2.81317175
86regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.79673226
87axoneme assembly (GO:0035082)2.75074096
88sulfation (GO:0051923)2.74659983
89mitotic cell cycle arrest (GO:0071850)2.70924626
90cilium or flagellum-dependent cell motility (GO:0001539)2.70238671
91negative regulation of reactive oxygen species metabolic process (GO:2000378)2.69871933
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.68417297
93potassium ion export (GO:0071435)2.67560708
94protein polyglutamylation (GO:0018095)2.66330887
95regulation of autophagic vacuole assembly (GO:2000785)2.65601396
96positive regulation of triglyceride biosynthetic process (GO:0010867)2.65244837
97C-terminal protein lipidation (GO:0006501)2.63422169
98epithelial cilium movement (GO:0003351)2.62736721
99GPI anchor biosynthetic process (GO:0006506)2.61365865
100neuron cell-cell adhesion (GO:0007158)2.60427193
101sodium ion export (GO:0071436)2.59755757
102post-embryonic morphogenesis (GO:0009886)2.59524660
103regulation of prostaglandin secretion (GO:0032306)2.58022195
104potassium ion homeostasis (GO:0055075)2.57374673
105cellular response to interferon-beta (GO:0035458)2.57287554
106negative regulation of T cell differentiation in thymus (GO:0033085)2.56985959
107phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56698024
108auditory receptor cell stereocilium organization (GO:0060088)2.56403355
109vesicle transport along microtubule (GO:0047496)2.55922959
110neuronal action potential (GO:0019228)2.55727466
111opioid receptor signaling pathway (GO:0038003)2.55271699
112positive regulation of membrane potential (GO:0045838)2.54932266
113fucose metabolic process (GO:0006004)2.54498978
114tRNA modification (GO:0006400)2.53849912
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52937088
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52937088
117protein localization to synapse (GO:0035418)2.51244205
118multicellular organism reproduction (GO:0032504)2.49590909
119ubiquinone metabolic process (GO:0006743)2.49568685
120regulation of type B pancreatic cell apoptotic process (GO:2000674)2.48832611
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.48103694
122C-terminal protein amino acid modification (GO:0018410)2.45379464
123positive regulation of neurotransmitter transport (GO:0051590)2.44963585
124negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.44298296
125regulation of glutamate receptor signaling pathway (GO:1900449)2.43939822
126organelle membrane fusion (GO:0090174)2.43302298
127regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42526720
128primary amino compound metabolic process (GO:1901160)2.42233514
129negative regulation of interleukin-1 production (GO:0032692)2.41159406
130regulation of meiotic cell cycle (GO:0051445)2.40942679
131synaptic vesicle endocytosis (GO:0048488)2.40537918
132piRNA metabolic process (GO:0034587)2.40139778
133synaptic transmission, cholinergic (GO:0007271)2.39857109
134alanine transport (GO:0032328)2.39840009
135establishment of synaptic vesicle localization (GO:0097480)2.39419077
136synaptic vesicle transport (GO:0048489)2.39419077
137positive regulation of organic acid transport (GO:0032892)2.39046015
138behavioral response to ethanol (GO:0048149)2.38889232
139kidney morphogenesis (GO:0060993)2.38846397
140transmission of nerve impulse (GO:0019226)2.38521986
141COPI coating of Golgi vesicle (GO:0048205)2.38433550
142Golgi transport vesicle coating (GO:0048200)2.38433550
143glutamate receptor signaling pathway (GO:0007215)2.38390882
144synaptic transmission, glutamatergic (GO:0035249)2.38328102
145rhodopsin mediated signaling pathway (GO:0016056)2.38235899
146positive regulation of CREB transcription factor activity (GO:0032793)2.38159755
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38149204
148heparin biosynthetic process (GO:0030210)2.37480814
149heparin metabolic process (GO:0030202)2.37480814
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36862528
151ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36583835
152regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.36416867
153potassium ion import (GO:0010107)2.35627132
154GTP biosynthetic process (GO:0006183)2.35506351
155regulation of synaptic transmission, glutamatergic (GO:0051966)2.34966604
156righting reflex (GO:0060013)2.34442475
157regulation of axon regeneration (GO:0048679)2.33691710
158regulation of neuron projection regeneration (GO:0070570)2.33691710
159positive regulation of granulocyte differentiation (GO:0030854)2.32715424
160proline transport (GO:0015824)2.32301431
161dendritic spine organization (GO:0097061)2.31685005
162DNA deamination (GO:0045006)2.31629209
163phosphatidylglycerol biosynthetic process (GO:0006655)2.30394678
164ionotropic glutamate receptor signaling pathway (GO:0035235)2.29087082
165energy homeostasis (GO:0097009)2.28676793
166relaxation of smooth muscle (GO:0044557)2.28561174
167membrane repolarization (GO:0086009)2.28258972
168regulation of exit from mitosis (GO:0007096)2.27802270
169glutamate secretion (GO:0014047)2.26009072
170regulation of vacuole organization (GO:0044088)2.25803715
171exploration behavior (GO:0035640)2.24330150
172regulation of actin nucleation (GO:0051125)2.24083174
173metallo-sulfur cluster assembly (GO:0031163)2.23981218
174iron-sulfur cluster assembly (GO:0016226)2.23981218
175establishment of vesicle localization (GO:0051650)2.23878659
176regulation of catecholamine metabolic process (GO:0042069)2.23732139
177regulation of dopamine metabolic process (GO:0042053)2.23732139
178bicarbonate transport (GO:0015701)2.23231237
179positive regulation of potassium ion transmembrane transport (GO:1901381)2.22075076
180membrane tubulation (GO:0097320)2.21886523
181positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.21778369
182meiotic cell cycle (GO:0051321)2.21677375
183negative regulation of neurotransmitter transport (GO:0051589)2.20319120
184positive regulation of synaptic transmission, GABAergic (GO:0032230)2.20132256
185regulation of amyloid precursor protein catabolic process (GO:1902991)2.20085880
186deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.19566297
187L-serine transport (GO:0015825)2.19466230
188neurotransmitter catabolic process (GO:0042135)2.18545901
189innervation (GO:0060384)2.17592610
190negative regulation of synaptic transmission, GABAergic (GO:0032229)2.17332447
191antigen processing and presentation via MHC class Ib (GO:0002475)2.14917268
192vesicle localization (GO:0051648)2.14420288
193DNA methylation involved in gamete generation (GO:0043046)2.14160159
194glycoside metabolic process (GO:0016137)2.13080162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49511959
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.38045972
3GBX2_23144817_ChIP-Seq_PC3_Human3.24330088
4IGF1R_20145208_ChIP-Seq_DFB_Human3.17412421
5VDR_22108803_ChIP-Seq_LS180_Human2.80583964
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68340511
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35326111
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.33801479
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15295197
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09015658
11REST_21632747_ChIP-Seq_MESCs_Mouse2.06994499
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06300044
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06239119
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.06108222
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04602055
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02099584
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98936995
18ERA_21632823_ChIP-Seq_H3396_Human1.95128719
19SCL_19346495_ChIP-Seq_HPC-7_Human1.85683675
20TP53_22573176_ChIP-Seq_HFKS_Human1.82740230
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.78224076
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.75246788
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72674979
24BCL6_27268052_Chip-Seq_Bcells_Human1.67779717
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67678009
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.67327524
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.66052841
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65729557
29* GATA3_21878914_ChIP-Seq_MCF-7_Human1.64997719
30TAF2_19829295_ChIP-Seq_ESCs_Human1.61973008
31E2F1_20622854_ChIP-Seq_HELA_Human1.57828861
32MYC_18940864_ChIP-ChIP_HL60_Human1.57372133
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57312860
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55835672
35* EWS_26573619_Chip-Seq_HEK293_Human1.54360324
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.53504399
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.53415125
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52838458
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52686116
40NANOG_20526341_ChIP-Seq_ESCs_Human1.51810835
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.51179734
42P53_21459846_ChIP-Seq_SAOS-2_Human1.50442734
43VDR_23849224_ChIP-Seq_CD4+_Human1.47015881
44IRF1_19129219_ChIP-ChIP_H3396_Human1.44755296
45PHF8_20622854_ChIP-Seq_HELA_Human1.44744523
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44158834
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.42220744
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42105708
49OCT4_20526341_ChIP-Seq_ESCs_Human1.41639045
50* FOXA1_25329375_ChIP-Seq_VCAP_Human1.40853245
51* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40853245
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40613917
53RAC3_21632823_ChIP-Seq_H3396_Human1.40416022
54P68_20966046_ChIP-Seq_HELA_Human1.39970868
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39189812
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.39092740
57P300_27268052_Chip-Seq_Bcells_Human1.37624799
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37197651
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37188012
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.36272702
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35898643
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35850343
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35850343
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34974322
65AR_20517297_ChIP-Seq_VCAP_Human1.32259433
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29739073
67MYC_19829295_ChIP-Seq_ESCs_Human1.28540348
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28329579
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28300233
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28141029
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27216359
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27076112
73ZNF274_21170338_ChIP-Seq_K562_Hela1.26858150
74BCOR_27268052_Chip-Seq_Bcells_Human1.26798438
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26735624
76FUS_26573619_Chip-Seq_HEK293_Human1.26560421
77SMAD4_21799915_ChIP-Seq_A2780_Human1.25296444
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25246617
79DROSHA_22980978_ChIP-Seq_HELA_Human1.25097508
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24715694
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24389895
82HOXB7_26014856_ChIP-Seq_BT474_Human1.23916250
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.23836518
84CTCF_20526341_ChIP-Seq_ESCs_Human1.23316496
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23091766
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22471724
87P300_19829295_ChIP-Seq_ESCs_Human1.21967866
88NCOR_22424771_ChIP-Seq_293T_Human1.21128591
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19937426
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.19881320
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19369725
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.19109126
93STAT3_23295773_ChIP-Seq_U87_Human1.18523232
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16620399
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.16156724
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14497974
97FOXH1_21741376_ChIP-Seq_ESCs_Human1.14110965
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13959296
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13839320
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.13429926
101RXR_22108803_ChIP-Seq_LS180_Human1.12814498
102* ER_23166858_ChIP-Seq_MCF-7_Human1.12243474
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11227148
104* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10074391
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09549579
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09353039
107RUNX_20019798_ChIP-Seq_JUKART_Human1.08661392
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08378573
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07952962
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07469647
111GATA3_26560356_Chip-Seq_TH2_Human1.06988361
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06687799
113AR_21572438_ChIP-Seq_LNCaP_Human1.04929456
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.04888569
115EED_16625203_ChIP-ChIP_MESCs_Mouse1.04450368
116TCF4_23295773_ChIP-Seq_U87_Human1.04249816
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03963648
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.03706095
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03332191
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.02897995
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02812207
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02195292
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01895702
124JUN_21703547_ChIP-Seq_K562_Human1.01782641
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.01649189
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.01625171
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00599975
128STAT1_20625510_ChIP-Seq_HELA_Human1.00070505
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00005066
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99662198
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.98724409
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98331913
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98254151
134RNF2_27304074_Chip-Seq_NSC_Mouse0.97925988
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97426475
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97369059
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96309977
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95696031
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95445951
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.95069807
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.95006471
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94777506
143SA1_27219007_Chip-Seq_Bcells_Human0.93956453
144* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92955819
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92917449
146NANOG_19829295_ChIP-Seq_ESCs_Human0.92887294
147SOX2_19829295_ChIP-Seq_ESCs_Human0.92887294
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92782258
149* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92735606
150STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92592556
151* AR_25329375_ChIP-Seq_VCAP_Human0.92546345
152OCT4_19829295_ChIP-Seq_ESCs_Human0.92320588
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.91410348
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90618639
155GATA1_19941826_ChIP-Seq_K562_Human0.90466162
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89006558
157TP53_16413492_ChIP-PET_HCT116_Human0.88803694
158FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87564222
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.87488730
160CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87130801
161HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87126075
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.86877719
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.86838864
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.86003397
165SPI1_23127762_ChIP-Seq_K562_Human0.85558513
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85047182
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84906980
168THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84174573
169NMYC_18555785_Chip-Seq_ESCs_Mouse0.83836631
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83751760
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.82883961
172PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82482377
173FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82338443
174SMAD3_21741376_ChIP-Seq_ESCs_Human0.82306441
175PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81458983
176SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81234735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.63115714
2MP0004270_analgesia2.87767252
3MP0003195_calcinosis2.83742198
4MP0003880_abnormal_central_pattern2.79823308
5MP0008875_abnormal_xenobiotic_pharmacok2.66274849
6MP0005645_abnormal_hypothalamus_physiol2.54187943
7MP0005646_abnormal_pituitary_gland2.50708305
8MP0003635_abnormal_synaptic_transmissio2.46312111
9MP0006292_abnormal_olfactory_placode2.44190928
10MP0002653_abnormal_ependyma_morphology2.20332322
11MP0003136_yellow_coat_color2.19006806
12MP0003879_abnormal_hair_cell2.14284004
13MP0002876_abnormal_thyroid_physiology2.06662919
14MP0002272_abnormal_nervous_system2.05167752
15MP0009046_muscle_twitch2.03558470
16MP0001485_abnormal_pinna_reflex2.02501471
17MP0002064_seizures1.99515414
18MP0001986_abnormal_taste_sensitivity1.98751064
19MP0006072_abnormal_retinal_apoptosis1.98040479
20MP0002909_abnormal_adrenal_gland1.97839836
21MP0002572_abnormal_emotion/affect_behav1.97127368
22MP0001968_abnormal_touch/_nociception1.93595865
23MP0003787_abnormal_imprinting1.92940723
24MP0005310_abnormal_salivary_gland1.91984315
25MP0003718_maternal_effect1.90040181
26MP0005377_hearing/vestibular/ear_phenot1.85794443
27MP0003878_abnormal_ear_physiology1.85794443
28MP0001486_abnormal_startle_reflex1.85086123
29MP0008004_abnormal_stomach_pH1.80750041
30MP0009745_abnormal_behavioral_response1.79990965
31MP0002837_dystrophic_cardiac_calcinosis1.79730896
32MP0008872_abnormal_physiological_respon1.77901660
33MP0001905_abnormal_dopamine_level1.77863653
34MP0005423_abnormal_somatic_nervous1.77492616
35MP0002396_abnormal_hematopoietic_system1.77357757
36MP0001529_abnormal_vocalization1.77230589
37MP0004147_increased_porphyrin_level1.75344245
38MP0002063_abnormal_learning/memory/cond1.72981257
39MP0003172_abnormal_lysosome_physiology1.66414223
40MP0002734_abnormal_mechanical_nocicepti1.63223979
41MP0010386_abnormal_urinary_bladder1.58218936
42MP0003011_delayed_dark_adaptation1.57104973
43MP0000427_abnormal_hair_cycle1.52053588
44MP0002067_abnormal_sensory_capabilities1.51780344
45MP0000569_abnormal_digit_pigmentation1.51638357
46MP0004885_abnormal_endolymph1.47473193
47MP0004133_heterotaxia1.47197359
48MP0002277_abnormal_respiratory_mucosa1.46486475
49MP0000631_abnormal_neuroendocrine_gland1.46335015
50MP0003806_abnormal_nucleotide_metabolis1.46064218
51MP0003656_abnormal_erythrocyte_physiolo1.43968437
52MP0001501_abnormal_sleep_pattern1.43013899
53MP0005671_abnormal_response_to1.42127700
54MP0002557_abnormal_social/conspecific_i1.41260911
55MP0005084_abnormal_gallbladder_morpholo1.41249054
56MP0005379_endocrine/exocrine_gland_phen1.41182705
57MP0006276_abnormal_autonomic_nervous1.40624212
58MP0002160_abnormal_reproductive_system1.40478517
59MP0004924_abnormal_behavior1.39190043
60MP0005386_behavior/neurological_phenoty1.39190043
61MP0002229_neurodegeneration1.38263009
62MP0002735_abnormal_chemical_nociception1.36951539
63MP0002736_abnormal_nociception_after1.35075930
64MP0004742_abnormal_vestibular_system1.33538891
65MP0001970_abnormal_pain_threshold1.32423433
66MP0008569_lethality_at_weaning1.29582384
67MP0002148_abnormal_hypersensitivity_rea1.28409989
68MP0001502_abnormal_circadian_rhythm1.28316776
69MP0002184_abnormal_innervation1.27572653
70MP0002693_abnormal_pancreas_physiology1.27435777
71MP0005389_reproductive_system_phenotype1.27414182
72MP0006054_spinal_hemorrhage1.27181594
73MP0001984_abnormal_olfaction1.26546161
74MP0001188_hyperpigmentation1.26428109
75MP0005551_abnormal_eye_electrophysiolog1.26036264
76MP0000538_abnormal_urinary_bladder1.25136110
77MP0002138_abnormal_hepatobiliary_system1.24253526
78MP0002733_abnormal_thermal_nociception1.23117017
79MP0000685_abnormal_immune_system1.22883691
80MP0003283_abnormal_digestive_organ1.21631464
81MP0003646_muscle_fatigue1.20397695
82MP0002928_abnormal_bile_duct1.17883791
83MP0001790_abnormal_immune_system1.17119780
84MP0005387_immune_system_phenotype1.17119780
85MP0009764_decreased_sensitivity_to1.14973156
86MP0003868_abnormal_feces_composition1.11355716
87MP0001919_abnormal_reproductive_system1.10101921
88MP0000230_abnormal_systemic_arterial1.08794122
89MP0001873_stomach_inflammation1.08701555
90MP0001800_abnormal_humoral_immune1.08697541
91MP0005167_abnormal_blood-brain_barrier1.08071628
92MP0001835_abnormal_antigen_presentation1.07410806
93MP0000372_irregular_coat_pigmentation1.06985865
94MP0004130_abnormal_muscle_cell1.05997648
95MP0008877_abnormal_DNA_methylation1.04950999
96MP0000681_abnormal_thyroid_gland1.04274195
97MP0005332_abnormal_amino_acid1.02923048
98MP0001944_abnormal_pancreas_morphology1.02751483
99MP0000383_abnormal_hair_follicle1.00841021
100MP0005075_abnormal_melanosome_morpholog1.00557644
101MP0000015_abnormal_ear_pigmentation1.00337087
102MP0001440_abnormal_grooming_behavior0.99842548
103MP0000955_abnormal_spinal_cord0.98840571
104MP0002882_abnormal_neuron_morphology0.98721381
105MP0002638_abnormal_pupillary_reflex0.96503253
106MP0004811_abnormal_neuron_physiology0.96417726
107MP0002090_abnormal_vision0.96345315
108MP0002234_abnormal_pharynx_morphology0.94710271
109MP0003763_abnormal_thymus_physiology0.93714659
110MP0003724_increased_susceptibility_to0.92711582
111MP0003633_abnormal_nervous_system0.91415057
112MP0002723_abnormal_immune_serum0.91141478
113MP0001663_abnormal_digestive_system0.91044758
114MP0000678_abnormal_parathyroid_gland0.90173165
115MP0005174_abnormal_tail_pigmentation0.90168723
116MP0003699_abnormal_female_reproductive0.89387502
117MP0002066_abnormal_motor_capabilities/c0.89061626
118MP0005410_abnormal_fertilization0.88700764
119MP0005409_darkened_coat_color0.88665621
120MP0001963_abnormal_hearing_physiology0.88429459
121MP0002095_abnormal_skin_pigmentation0.87405509
122MP0000026_abnormal_inner_ear0.87003604
123MP0003300_gastrointestinal_ulcer0.86853340
124MP0001324_abnormal_eye_pigmentation0.86396789
125MP0003137_abnormal_impulse_conducting0.86344628
126MP0005171_absent_coat_pigmentation0.86166416
127MP0004142_abnormal_muscle_tone0.85879316
128MP0000920_abnormal_myelination0.85328550
129MP0005195_abnormal_posterior_eye0.84699546
130MP0003866_abnormal_defecation0.83814965
131MP0005083_abnormal_biliary_tract0.83512649
132MP0003634_abnormal_glial_cell0.81202944
133MP0001664_abnormal_digestion0.78652094
134MP0001765_abnormal_ion_homeostasis0.78207938
135MP0003121_genomic_imprinting0.77245293
136MP0005253_abnormal_eye_physiology0.75434268
137MP0003183_abnormal_peptide_metabolism0.75271239
138MP0002102_abnormal_ear_morphology0.74445835
139MP0002398_abnormal_bone_marrow0.73691560
140MP0004145_abnormal_muscle_electrophysio0.72924565
141MP0002752_abnormal_somatic_nervous0.72243886
142MP0000639_abnormal_adrenal_gland0.71878546
143MP0002877_abnormal_melanocyte_morpholog0.71027879
144MP0004043_abnormal_pH_regulation0.70141732
145MP0004858_abnormal_nervous_system0.70006749
146MP0003631_nervous_system_phenotype0.69742113
147MP0002152_abnormal_brain_morphology0.68993253
148MP0003693_abnormal_embryo_hatching0.67483387

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.08335056
2Visual hallucinations (HP:0002367)3.87770500
3Unilateral renal agenesis (HP:0000122)3.63340934
4Abnormality of calcium-phosphate metabolism (HP:0100530)3.40264270
5Nephronophthisis (HP:0000090)3.28540296
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.21101012
7Abolished electroretinogram (ERG) (HP:0000550)3.20039808
8Attenuation of retinal blood vessels (HP:0007843)3.11488550
9True hermaphroditism (HP:0010459)3.10488974
10Abnormal drinking behavior (HP:0030082)3.06083628
11Polydipsia (HP:0001959)3.06083628
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.99304965
13Decreased electroretinogram (ERG) amplitude (HP:0000654)2.96318085
14Aplastic anemia (HP:0001915)2.95350435
15Abnormality of dental color (HP:0011073)2.92896956
16Concave nail (HP:0001598)2.86939614
17Abnormality of the renal medulla (HP:0100957)2.81001469
18Mitochondrial inheritance (HP:0001427)2.77873325
19Hyperventilation (HP:0002883)2.75600775
20Medial flaring of the eyebrow (HP:0010747)2.74005492
21Large for gestational age (HP:0001520)2.71647615
22Tubular atrophy (HP:0000092)2.66108895
23Epileptic encephalopathy (HP:0200134)2.65521821
24Retinal dysplasia (HP:0007973)2.63778585
25Abnormality of the renal cortex (HP:0011035)2.63481233
26Absent/shortened dynein arms (HP:0200106)2.60164847
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.60164847
28Type II lissencephaly (HP:0007260)2.59403629
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55483168
30Increased CSF lactate (HP:0002490)2.55304798
31Patellar aplasia (HP:0006443)2.54769426
32Nonprogressive disorder (HP:0003680)2.53022295
33Aplasia/Hypoplasia of the patella (HP:0006498)2.51114796
34Severe muscular hypotonia (HP:0006829)2.49848319
35Chronic otitis media (HP:0000389)2.49810232
36Decreased circulating renin level (HP:0003351)2.48639924
37Lipid accumulation in hepatocytes (HP:0006561)2.48555849
38Hyperphosphatemia (HP:0002905)2.45158440
39Abnormal rod and cone electroretinograms (HP:0008323)2.43827420
40Inability to walk (HP:0002540)2.43699628
41Cystic liver disease (HP:0006706)2.43602656
42Clumsiness (HP:0002312)2.42684992
43Acute necrotizing encephalopathy (HP:0006965)2.40258475
44Abnormal number of erythroid precursors (HP:0012131)2.36698030
45Agitation (HP:0000713)2.36300243
46Diplopia (HP:0000651)2.36225879
47Abnormality of binocular vision (HP:0011514)2.36225879
48Genetic anticipation (HP:0003743)2.35903347
493-Methylglutaconic aciduria (HP:0003535)2.33002180
50Mesangial abnormality (HP:0001966)2.32948225
51Birth length less than 3rd percentile (HP:0003561)2.32596294
52Focal seizures (HP:0007359)2.31878454
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31422686
54Stomatitis (HP:0010280)2.29030391
55Polyuria (HP:0000103)2.28633901
56Abnormality of the pons (HP:0007361)2.27446294
57Pendular nystagmus (HP:0012043)2.27172724
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.27118544
59Atonic seizures (HP:0010819)2.26477082
60Hepatocellular necrosis (HP:0001404)2.26346810
61Type I transferrin isoform profile (HP:0003642)2.25562495
62Myokymia (HP:0002411)2.24091138
63Microretrognathia (HP:0000308)2.22921117
64IgM deficiency (HP:0002850)2.22734137
65Hypoplasia of the pons (HP:0012110)2.22393473
66Bile duct proliferation (HP:0001408)2.21164822
67Abnormal biliary tract physiology (HP:0012439)2.21164822
68Sclerocornea (HP:0000647)2.19190085
69Increased hepatocellular lipid droplets (HP:0006565)2.18686838
70Renal Fanconi syndrome (HP:0001994)2.18367858
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18366901
72Acute encephalopathy (HP:0006846)2.17837333
73Optic disc pallor (HP:0000543)2.17247547
74Severe visual impairment (HP:0001141)2.16041198
75Decreased central vision (HP:0007663)2.15911755
76Febrile seizures (HP:0002373)2.14623290
77Rib fusion (HP:0000902)2.13782724
78Papilledema (HP:0001085)2.13433077
79Abnormal mitochondria in muscle tissue (HP:0008316)2.12904456
80Parakeratosis (HP:0001036)2.12507269
81Lymphopenia (HP:0001888)2.12505601
82Testicular atrophy (HP:0000029)2.12477182
83Depression (HP:0000716)2.12106598
84Cerebellar dysplasia (HP:0007033)2.12103764
85Fibular aplasia (HP:0002990)2.11429289
86Gait imbalance (HP:0002141)2.11151411
87Gastrointestinal stroma tumor (HP:0100723)2.10844143
88Lissencephaly (HP:0001339)2.08048953
89Hepatic necrosis (HP:0002605)2.07329863
90Truncal ataxia (HP:0002078)2.05078153
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04193638
92Abnormal protein N-linked glycosylation (HP:0012347)2.04193638
93Abnormal protein glycosylation (HP:0012346)2.04193638
94Abnormal glycosylation (HP:0012345)2.04193638
95Congenital primary aphakia (HP:0007707)2.03488820
96Ketosis (HP:0001946)2.03358964
97Congenital hepatic fibrosis (HP:0002612)2.03215239
98Gaze-evoked nystagmus (HP:0000640)2.02375579
99Degeneration of the lateral corticospinal tracts (HP:0002314)2.01700585
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01700585
101Increased cerebral lipofuscin (HP:0011813)2.01230235
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97876597
103Progressive microcephaly (HP:0000253)1.96013444
104Dysostosis multiplex (HP:0000943)1.95436777
105Hypergonadotropic hypogonadism (HP:0000815)1.95207346
106Elevated erythrocyte sedimentation rate (HP:0003565)1.95102527
107Abnormality of cells of the erythroid lineage (HP:0012130)1.95020113
108Protruding tongue (HP:0010808)1.94616721
109Spinal canal stenosis (HP:0003416)1.94404135
110Progressive macrocephaly (HP:0004481)1.92134355
111Dialeptic seizures (HP:0011146)1.90517634
112Bony spicule pigmentary retinopathy (HP:0007737)1.90455102
113Hypothermia (HP:0002045)1.90143106
114Absent speech (HP:0001344)1.90009821
115Progressive neurologic deterioration (HP:0002344)1.88973514
116Ketoacidosis (HP:0001993)1.88610358
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.88495558
118Progressive inability to walk (HP:0002505)1.88448794
119Nephrogenic diabetes insipidus (HP:0009806)1.88369279
120Anxiety (HP:0000739)1.88173258
121Stomach cancer (HP:0012126)1.88022841
122Methylmalonic aciduria (HP:0012120)1.87016700
123Congenital stationary night blindness (HP:0007642)1.86972457
124Molar tooth sign on MRI (HP:0002419)1.85588543
125Abnormality of midbrain morphology (HP:0002418)1.85588543
126Chromsome breakage (HP:0040012)1.85319140
127Chorioretinal atrophy (HP:0000533)1.83509843
128Increased serum lactate (HP:0002151)1.83246629
129Panhypogammaglobulinemia (HP:0003139)1.82136624
130Congenital, generalized hypertrichosis (HP:0004540)1.81703195
131Progressive cerebellar ataxia (HP:0002073)1.81344164
132Mutism (HP:0002300)1.81295828
133Amelogenesis imperfecta (HP:0000705)1.79704259
134Pachygyria (HP:0001302)1.79539292
135Chronic hepatic failure (HP:0100626)1.78621295
136Absence seizures (HP:0002121)1.78567132
137Polyphagia (HP:0002591)1.77776799
138Lactic acidosis (HP:0003128)1.77130926
139Abnormal urine output (HP:0012590)1.76958040
140Tachypnea (HP:0002789)1.76556231
141Furrowed tongue (HP:0000221)1.76112080
142Vacuolated lymphocytes (HP:0001922)1.76035799
143Abnormality of alanine metabolism (HP:0010916)1.75333267
144Hyperalaninemia (HP:0003348)1.75333267
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75333267
146Dysmetria (HP:0001310)1.74123339
147Abnormality of macular pigmentation (HP:0008002)1.72837564
148Cortical visual impairment (HP:0100704)1.70424241
149Thyroid-stimulating hormone excess (HP:0002925)1.69786087
150Cholecystitis (HP:0001082)1.69491316
151Abnormal gallbladder physiology (HP:0012438)1.69491316
152Diminished motivation (HP:0000745)1.68936647
153Supranuclear gaze palsy (HP:0000605)1.67923488
154Pulmonary fibrosis (HP:0002206)1.66528966
155Pancreatic cysts (HP:0001737)1.66468588
156Ankle clonus (HP:0011448)1.66460245
157Generalized tonic-clonic seizures (HP:0002069)1.65819085
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.65785599
159Pancreatic fibrosis (HP:0100732)1.65206022
160Spastic gait (HP:0002064)1.64983231
161Abnormality of the columella (HP:0009929)1.64571508
162Macroglossia (HP:0000158)1.62646960
163Cheilitis (HP:0100825)1.62504579
164Psychosis (HP:0000709)1.62293844
165Neuroendocrine neoplasm (HP:0100634)1.62248827
166IgG deficiency (HP:0004315)1.60236778
167Pheochromocytoma (HP:0002666)1.59680851
168Abnormal ciliary motility (HP:0012262)1.57969771
169Apathy (HP:0000741)1.56455385
170Fetal akinesia sequence (HP:0001989)1.55966706
171Tetany (HP:0001281)1.55776621
172Abnormal respiratory motile cilium morphology (HP:0005938)1.55642771
173Abnormal respiratory epithelium morphology (HP:0012253)1.55642771
174Action tremor (HP:0002345)1.55622320
175Termporal pattern (HP:0011008)1.55416901
176Insidious onset (HP:0003587)1.55416901
177Agammaglobulinemia (HP:0004432)1.55268419
178Type 2 muscle fiber atrophy (HP:0003554)1.54980250
179Slow saccadic eye movements (HP:0000514)1.53495581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.15132100
2TAOK35.03857527
3FRK4.42317691
4TLK13.85736632
5WNK43.42405189
6MAP2K73.04125199
7MUSK2.99667526
8ZAK2.94403978
9SIK32.81017310
10CDK192.65289182
11GRK12.57131870
12MAP3K132.39551017
13MAP3K122.33853449
14MAP3K42.32375653
15MOS2.22201197
16BCKDK2.20469713
17CAMKK22.15203546
18MAP3K92.11090263
19DAPK22.08938289
20MAP4K22.08896170
21NTRK32.07028992
22SIK21.98539308
23MAPK131.94369154
24NUAK11.87564845
25MAP3K61.84781021
26PINK11.71617629
27EPHA41.64773370
28ADRBK11.63802277
29FES1.63525978
30BMPR21.62680994
31PRKD31.59945839
32MAP3K111.56396658
33TGFBR11.55677101
34WNK31.50927647
35MAPKAPK51.46222183
36TXK1.44735233
37INSRR1.41208490
38MAPKAPK31.39953142
39IKBKB1.37509357
40VRK21.36966597
41ARAF1.31616019
42KIT1.29379147
43VRK11.28354022
44HIPK21.19262741
45STK161.15735486
46TNK21.13632269
47BRAF1.11915721
48ACVR1B1.11915434
49MAP2K61.11408384
50CDK81.07132003
51KSR21.07041455
52CSNK1G21.06689217
53CAMK11.04685100
54NLK1.03122335
55RPS6KA51.01342257
56STK391.00357581
57PIM20.99747337
58GRK60.99371886
59SIK10.99298300
60ABL20.97133092
61CSNK1G30.95754441
62SCYL20.92683078
63MAP4K10.91216668
64MARK20.89640208
65TEC0.89196537
66RAF10.87248163
67EIF2AK10.86812536
68TGFBR20.86778557
69RPS6KA60.85888269
70DAPK10.85539769
71OXSR10.84411912
72NTRK10.84365877
73NTRK20.83974592
74BRSK10.83915855
75MAP2K40.81959956
76CDK50.79397512
77CSNK1G10.78760212
78CHEK20.77495374
79TIE10.76483919
80PRKCI0.75908716
81PRKCQ0.75760835
82CSNK1A1L0.75691977
83IKBKE0.75530337
84CHUK0.74543236
85MINK10.74473494
86PIK3CA0.73129802
87TAOK10.71969126
88RET0.68979942
89CSF1R0.64994700
90PRKCG0.64962794
91MAP2K20.64534686
92MAP3K10.62984967
93CDK30.62905814
94LATS10.62558340
95STK100.62547361
96CAMKK10.62307808
97PRKD20.61998413
98TBK10.61766972
99SYK0.61139228
100PKN10.60817593
101PTK2B0.59856869
102LYN0.59151020
103PHKG20.59051598
104PHKG10.59051598
105IRAK40.57657721
106CAMK2B0.55878477
107PRKCE0.54696838
108CDC70.53909916
109ADRBK20.53429201
110PAK60.53398033
111PLK20.52839504
112CCNB10.52550355
113TESK20.51126689
114CAMK1D0.49996269
115CAMK2A0.49637672
116NME10.49423967
117BRD40.47760202
118GRK50.46378376
119LCK0.45820061
120TRIM280.45778997
121STK110.44451182
122DYRK20.44261416
123PIK3CG0.43652739
124BMPR1B0.42569791
125UHMK10.42193810
126MARK10.41883535
127PAK30.41302195
128MATK0.41255537
129IRAK10.40567598
130JAK30.40274335
131CSNK1A10.39621734
132CDK90.39470532
133FLT30.38464149
134PRKACA0.36830806
135MAP3K20.35800857
136BTK0.35686223
137PRKG20.35405411
138MAPK150.34601914
139CASK0.34435356
140NEK20.34420518
141PRKCA0.33223264
142CDK140.32626679
143KDR0.31505990
144PRKG10.31402723
145ZAP700.31343271
146BLK0.30601194
147DYRK1A0.29869805
148TAF10.29802039
149CDK11A0.29116116
150EPHA30.28842528
151FYN0.28464488
152GRK70.28310100
153ITK0.27671158
154LRRK20.26874531
155CAMK2G0.26222823

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.13988594
2Oxidative phosphorylation_Homo sapiens_hsa001902.69035120
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.63816067
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52494856
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50221270
6Asthma_Homo sapiens_hsa053102.39481626
7Linoleic acid metabolism_Homo sapiens_hsa005912.28340504
8Nicotine addiction_Homo sapiens_hsa050332.26529599
9Nitrogen metabolism_Homo sapiens_hsa009102.15152771
10Protein export_Homo sapiens_hsa030602.12100016
11Synaptic vesicle cycle_Homo sapiens_hsa047212.02256066
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00711970
13Glutamatergic synapse_Homo sapiens_hsa047241.94339146
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90282043
15Parkinsons disease_Homo sapiens_hsa050121.88106397
16Insulin secretion_Homo sapiens_hsa049111.86590653
17Circadian entrainment_Homo sapiens_hsa047131.79031035
18GABAergic synapse_Homo sapiens_hsa047271.75576724
19Morphine addiction_Homo sapiens_hsa050321.73106919
20Olfactory transduction_Homo sapiens_hsa047401.72566926
21Serotonergic synapse_Homo sapiens_hsa047261.67080544
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65728262
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63568242
24Butanoate metabolism_Homo sapiens_hsa006501.58560425
25Long-term potentiation_Homo sapiens_hsa047201.56534550
26Selenocompound metabolism_Homo sapiens_hsa004501.56029655
27Allograft rejection_Homo sapiens_hsa053301.54779932
28Dopaminergic synapse_Homo sapiens_hsa047281.53437418
29Tryptophan metabolism_Homo sapiens_hsa003801.52865204
30RNA polymerase_Homo sapiens_hsa030201.52685530
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51327419
32Cholinergic synapse_Homo sapiens_hsa047251.49953287
33Ribosome_Homo sapiens_hsa030101.48669981
34Graft-versus-host disease_Homo sapiens_hsa053321.43147684
35Autoimmune thyroid disease_Homo sapiens_hsa053201.42843574
36Taste transduction_Homo sapiens_hsa047421.42220101
37N-Glycan biosynthesis_Homo sapiens_hsa005101.41248923
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40462967
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40149519
40Ovarian steroidogenesis_Homo sapiens_hsa049131.37679805
41Circadian rhythm_Homo sapiens_hsa047101.34286244
42Amphetamine addiction_Homo sapiens_hsa050311.30867453
43Salivary secretion_Homo sapiens_hsa049701.28919525
44Huntingtons disease_Homo sapiens_hsa050161.27500683
45Alzheimers disease_Homo sapiens_hsa050101.26380825
46Arachidonic acid metabolism_Homo sapiens_hsa005901.24360108
47Long-term depression_Homo sapiens_hsa047301.24063807
48Non-homologous end-joining_Homo sapiens_hsa034501.23416139
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22893876
50Cocaine addiction_Homo sapiens_hsa050301.21945946
51Caffeine metabolism_Homo sapiens_hsa002321.20833263
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18580016
53Peroxisome_Homo sapiens_hsa041461.17424727
54Type I diabetes mellitus_Homo sapiens_hsa049401.16001661
55Fanconi anemia pathway_Homo sapiens_hsa034601.15817415
56Primary immunodeficiency_Homo sapiens_hsa053401.14179411
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14164505
58Gastric acid secretion_Homo sapiens_hsa049711.14024131
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12293927
60DNA replication_Homo sapiens_hsa030301.06347418
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05991669
62Cardiac muscle contraction_Homo sapiens_hsa042601.05723213
63Sphingolipid metabolism_Homo sapiens_hsa006001.04784810
64ABC transporters_Homo sapiens_hsa020101.04166543
65Sphingolipid signaling pathway_Homo sapiens_hsa040711.03031667
66Ether lipid metabolism_Homo sapiens_hsa005651.02744864
67Rheumatoid arthritis_Homo sapiens_hsa053231.02719101
68Vibrio cholerae infection_Homo sapiens_hsa051101.02024499
69Regulation of autophagy_Homo sapiens_hsa041401.01598622
70Oxytocin signaling pathway_Homo sapiens_hsa049211.00924206
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99752581
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98793976
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97357856
74GnRH signaling pathway_Homo sapiens_hsa049120.96142745
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.95543822
76Basal transcription factors_Homo sapiens_hsa030220.94781710
77Calcium signaling pathway_Homo sapiens_hsa040200.94675692
78Homologous recombination_Homo sapiens_hsa034400.94239241
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94204407
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.93988935
81RNA degradation_Homo sapiens_hsa030180.92244326
82Renin secretion_Homo sapiens_hsa049240.92095611
83Collecting duct acid secretion_Homo sapiens_hsa049660.91112904
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90959990
85cAMP signaling pathway_Homo sapiens_hsa040240.90599001
86Type II diabetes mellitus_Homo sapiens_hsa049300.90379601
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.89850961
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89199093
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88728346
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88484931
91Oocyte meiosis_Homo sapiens_hsa041140.87836570
92Pancreatic cancer_Homo sapiens_hsa052120.87705980
93Chemical carcinogenesis_Homo sapiens_hsa052040.87139940
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.86641800
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86416239
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84548760
97One carbon pool by folate_Homo sapiens_hsa006700.84187308
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83990363
99Choline metabolism in cancer_Homo sapiens_hsa052310.83525433
100Cell cycle_Homo sapiens_hsa041100.81761949
101Lysosome_Homo sapiens_hsa041420.81594566
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79867233
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77548067
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77041791
105Ras signaling pathway_Homo sapiens_hsa040140.76879785
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.73373439
107Alcoholism_Homo sapiens_hsa050340.72287898
108Pancreatic secretion_Homo sapiens_hsa049720.72257058
109Thyroid hormone synthesis_Homo sapiens_hsa049180.72062730
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.70840039
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70100625
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69050060
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67650979
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67456027
115Pyrimidine metabolism_Homo sapiens_hsa002400.67088829
116Hematopoietic cell lineage_Homo sapiens_hsa046400.66150876
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65992124
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65153047
119Antigen processing and presentation_Homo sapiens_hsa046120.64315578
120Gap junction_Homo sapiens_hsa045400.63223880
121Dorso-ventral axis formation_Homo sapiens_hsa043200.61349131
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.61087150
123Other glycan degradation_Homo sapiens_hsa005110.60809826
124Colorectal cancer_Homo sapiens_hsa052100.60781809
125Phototransduction_Homo sapiens_hsa047440.60020161
126Metabolic pathways_Homo sapiens_hsa011000.59945611
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59886297
128Sulfur metabolism_Homo sapiens_hsa009200.59690829
129Axon guidance_Homo sapiens_hsa043600.59407536
130Glioma_Homo sapiens_hsa052140.58891886
131Glycerolipid metabolism_Homo sapiens_hsa005610.58477226
132p53 signaling pathway_Homo sapiens_hsa041150.58204859
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58166796
134Platelet activation_Homo sapiens_hsa046110.57322628
135Purine metabolism_Homo sapiens_hsa002300.56772957
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55529126
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.54237297
138Vitamin digestion and absorption_Homo sapiens_hsa049770.53577008
139ErbB signaling pathway_Homo sapiens_hsa040120.50689537
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49838664
141Mineral absorption_Homo sapiens_hsa049780.49561353
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49156698
143MAPK signaling pathway_Homo sapiens_hsa040100.47868675
144Prolactin signaling pathway_Homo sapiens_hsa049170.47701200
145Wnt signaling pathway_Homo sapiens_hsa043100.47056848
146Estrogen signaling pathway_Homo sapiens_hsa049150.46953585
147mTOR signaling pathway_Homo sapiens_hsa041500.46547785
148Mismatch repair_Homo sapiens_hsa034300.45799873
149Staphylococcus aureus infection_Homo sapiens_hsa051500.45416245
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45415096
151T cell receptor signaling pathway_Homo sapiens_hsa046600.45102709
152Renal cell carcinoma_Homo sapiens_hsa052110.45063234
153Sulfur relay system_Homo sapiens_hsa041220.44348492
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42914597
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42351502
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37659653
157Fat digestion and absorption_Homo sapiens_hsa049750.32669976
158beta-Alanine metabolism_Homo sapiens_hsa004100.31600476
159Histidine metabolism_Homo sapiens_hsa003400.30650897
160Retinol metabolism_Homo sapiens_hsa008300.29624394
161NF-kappa B signaling pathway_Homo sapiens_hsa040640.26785683

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