ZDHHC4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein glycosylation (GO:0060049)9.08262211
2regulation of B cell receptor signaling pathway (GO:0050855)5.64816524
3positive regulation of gamma-delta T cell activation (GO:0046645)5.64389237
4detection of molecule of bacterial origin (GO:0032490)5.20537491
5sphingosine metabolic process (GO:0006670)5.04705047
6regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.84957178
7microglial cell activation (GO:0001774)4.62236846
8B cell proliferation (GO:0042100)4.51088015
9diol metabolic process (GO:0034311)4.45379535
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.43207958
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.39929987
12regulation of gamma-delta T cell activation (GO:0046643)4.37785384
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34699215
14negative regulation of cell killing (GO:0031342)4.34699215
15regulation of gamma-delta T cell differentiation (GO:0045586)4.26406144
16B cell receptor signaling pathway (GO:0050853)4.16189551
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.08686378
18modulation by symbiont of host immune response (GO:0052553)4.08686378
19positive regulation by symbiont of host defense response (GO:0052509)4.08686378
20modulation by symbiont of host defense response (GO:0052031)4.08686378
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08686378
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08686378
23negative regulation of glycoprotein biosynthetic process (GO:0010561)3.96511816
24positive regulation of interferon-alpha production (GO:0032727)3.95890894
25sphingoid metabolic process (GO:0046519)3.94576115
26phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.91271171
27regulation of interferon-alpha production (GO:0032647)3.87636809
28regulation of histone H3-K27 methylation (GO:0061085)3.83458521
29regulation of glycoprotein biosynthetic process (GO:0010559)3.80952059
30macrophage activation involved in immune response (GO:0002281)3.77837801
31detection of external biotic stimulus (GO:0098581)3.72157811
32response to type I interferon (GO:0034340)3.71574225
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67749139
34cellular response to type I interferon (GO:0071357)3.67516608
35type I interferon signaling pathway (GO:0060337)3.67516608
36peptidyl-lysine trimethylation (GO:0018023)3.61720784
37negative regulation of B cell proliferation (GO:0030889)3.53505239
38hepatocyte apoptotic process (GO:0097284)3.52412609
39cellular response to ethanol (GO:0071361)3.48834869
40macrophage activation (GO:0042116)3.43708659
41negative regulation of T cell mediated immunity (GO:0002710)3.42382532
42negative T cell selection (GO:0043383)3.42077829
43cellular response to virus (GO:0098586)3.41122818
44negative thymic T cell selection (GO:0045060)3.38849951
45myeloid leukocyte mediated immunity (GO:0002444)3.37711930
46neutrophil mediated immunity (GO:0002446)3.37034952
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.34202634
48positive thymic T cell selection (GO:0045059)3.30793153
49negative regulation of interleukin-12 production (GO:0032695)3.24761147
50detection of biotic stimulus (GO:0009595)3.24593136
51positive T cell selection (GO:0043368)3.24117182
52regulation of pigment cell differentiation (GO:0050932)3.23744561
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21453940
54interferon-gamma-mediated signaling pathway (GO:0060333)3.20125527
55histone H3-K36 demethylation (GO:0070544)3.17934040
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17777607
57response to host immune response (GO:0052572)3.17777607
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.16071019
59embryonic process involved in female pregnancy (GO:0060136)3.12543584
60positive regulation of developmental pigmentation (GO:0048087)3.12069381
61positive regulation of interferon-beta production (GO:0032728)3.11523321
62germinal center formation (GO:0002467)3.10611726
63negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.05400376
64necrotic cell death (GO:0070265)3.05091737
65negative regulation of complement activation (GO:0045916)3.04794277
66histone H3-K9 modification (GO:0061647)3.04456371
67detection of other organism (GO:0098543)3.03640747
68regulation of interferon-beta biosynthetic process (GO:0045357)3.03229341
69mature B cell differentiation (GO:0002335)3.02253491
70regulation of glycoprotein metabolic process (GO:1903018)3.01563751
71lymphocyte proliferation (GO:0046651)3.01431265
72regulation of necroptotic process (GO:0060544)3.00345399
73antigen processing and presentation of endogenous antigen (GO:0019883)2.98890071
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98813153
75negative regulation of immunoglobulin mediated immune response (GO:0002890)2.98741495
76negative regulation of B cell mediated immunity (GO:0002713)2.98741495
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98538404
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95577313
79T cell proliferation (GO:0042098)2.95346665
80mononuclear cell proliferation (GO:0032943)2.93020449
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90197470
82negative regulation of glycoprotein metabolic process (GO:1903019)2.88752098
83positive regulation of humoral immune response (GO:0002922)2.86057715
84histone mRNA catabolic process (GO:0071044)2.85955217
85response to host (GO:0075136)2.85913985
86response to host defenses (GO:0052200)2.85913985
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85913985
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84802589
89response to interferon-alpha (GO:0035455)2.83939113
90programmed necrotic cell death (GO:0097300)2.83343126
91positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.81648622
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.81648622
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81319577
94defense response to protozoan (GO:0042832)2.81283636
95regulation of regulatory T cell differentiation (GO:0045589)2.80780031
96regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.79959173
97regulation of alpha-beta T cell proliferation (GO:0046640)2.79573926
98monoubiquitinated protein deubiquitination (GO:0035520)2.79042743
99negative regulation of adaptive immune response (GO:0002820)2.76433793
100protein K11-linked deubiquitination (GO:0035871)2.74294105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.72088063
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.90634564
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86438029
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.54005307
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41745150
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90271384
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.75171575
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.57578353
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49191685
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46506248
11SCL_19346495_ChIP-Seq_HPC-7_Human2.44339183
12RUNX_20019798_ChIP-Seq_JUKART_Human2.36928914
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.22141682
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17541524
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17511954
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.16355165
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08722307
18MYB_26560356_Chip-Seq_TH2_Human1.87076358
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83145729
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79638610
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79638610
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71716269
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69500188
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68462097
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65934424
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62250264
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59743414
28PRDM14_20953172_ChIP-Seq_ESCs_Human1.58465325
29AR_21572438_ChIP-Seq_LNCaP_Human1.55074652
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.51705588
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51445451
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50737695
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50489943
34IGF1R_20145208_ChIP-Seq_DFB_Human1.49995698
35GATA3_27048872_Chip-Seq_THYMUS_Human1.48679524
36VDR_24787735_ChIP-Seq_THP-1_Human1.48019889
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40435738
38GATA3_26560356_Chip-Seq_TH2_Human1.39997775
39CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39314457
40ER_23166858_ChIP-Seq_MCF-7_Human1.39203583
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.36640944
42GATA1_22025678_ChIP-Seq_K562_Human1.35372404
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31883394
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27954945
45MYB_26560356_Chip-Seq_TH1_Human1.27075525
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.24507832
47OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23092240
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22846358
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22812471
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21499215
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19169131
52P300_19829295_ChIP-Seq_ESCs_Human1.17479095
53SPI1_23127762_ChIP-Seq_K562_Human1.16750342
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15696601
55SPI1_23547873_ChIP-Seq_NB4_Human1.15533132
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14210104
57TP53_16413492_ChIP-PET_HCT116_Human1.14127459
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11893545
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.11891820
60SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11658957
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10111607
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09997277
63TCF4_23295773_ChIP-Seq_U87_Human1.09283828
64STAT3_23295773_ChIP-Seq_U87_Human1.08997878
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.08382298
66PU_27001747_Chip-Seq_BMDM_Mouse1.07202737
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06811485
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.06719811
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06669709
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05096722
71CBP_20019798_ChIP-Seq_JUKART_Human1.05096722
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.04801283
73SMRT_27268052_Chip-Seq_Bcells_Human1.04787474
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04513272
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.04334306
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.03530961
77TP63_23658742_ChIP-Seq_EP156T_Human1.02890769
78CDX2_22108803_ChIP-Seq_LS180_Human1.00913640
79GATA2_19941826_ChIP-Seq_K562_Human0.99084723
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94675113
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94417929
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.93578229
83OCT4_18555785_Chip-Seq_ESCs_Mouse0.93153353
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.92869919
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92569051
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92068088
87GATA3_26560356_Chip-Seq_TH1_Human0.91667308
88P53_22387025_ChIP-Seq_ESCs_Mouse0.90277713
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89788272
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89760581
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.89638579
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89300756
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88498107
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86118497
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85662969
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.84453177
97CTCF_18555785_Chip-Seq_ESCs_Mouse0.84036504
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.83947481
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83638771
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83132917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.79223624
2MP0003787_abnormal_imprinting3.51729032
3MP0001835_abnormal_antigen_presentation3.31031208
4MP0002837_dystrophic_cardiac_calcinosis3.25726499
5MP0003724_increased_susceptibility_to3.14428380
6MP0004381_abnormal_hair_follicle3.11016049
7MP0008260_abnormal_autophagy3.08607824
8MP0002653_abnormal_ependyma_morphology2.94171578
9MP0005171_absent_coat_pigmentation2.66335881
10MP0001800_abnormal_humoral_immune2.60540232
11MP0003045_fibrosis2.57559129
12MP0008057_abnormal_DNA_replication2.56856547
13MP0008877_abnormal_DNA_methylation2.40693060
14MP0003763_abnormal_thymus_physiology2.28574329
15MP0001790_abnormal_immune_system2.19909612
16MP0005387_immune_system_phenotype2.19909612
17MP0002452_abnormal_antigen_presenting2.14948667
18MP0003646_muscle_fatigue2.14891574
19MP0003303_peritoneal_inflammation2.12224491
20MP0000685_abnormal_immune_system2.09238259
21MP0003890_abnormal_embryonic-extraembry2.07020279
22MP0002723_abnormal_immune_serum2.06716564
23MP0003136_yellow_coat_color2.06394014
24MP0005075_abnormal_melanosome_morpholog2.01804709
25MP0009785_altered_susceptibility_to1.99305111
26MP0005174_abnormal_tail_pigmentation1.90108469
27MP0002420_abnormal_adaptive_immunity1.89632686
28MP0005000_abnormal_immune_tolerance1.87892437
29MP0001819_abnormal_immune_cell1.87707984
30MP0003300_gastrointestinal_ulcer1.85499035
31MP0002332_abnormal_exercise_endurance1.84247468
32MP0005671_abnormal_response_to1.81737869
33MP0003172_abnormal_lysosome_physiology1.81509943
34MP0000015_abnormal_ear_pigmentation1.72913260
35MP0005025_abnormal_response_to1.72106962
36MP0002419_abnormal_innate_immunity1.71298130
37MP0003656_abnormal_erythrocyte_physiolo1.70147002
38MP0002138_abnormal_hepatobiliary_system1.67632321
39MP0000716_abnormal_immune_system1.63606486
40MP0002398_abnormal_bone_marrow1.59258040
41MP0005451_abnormal_body_composition1.58617255
42MP0002166_altered_tumor_susceptibility1.50612014
43MP0000427_abnormal_hair_cycle1.50443574
44MP0002148_abnormal_hypersensitivity_rea1.44035401
45MP0000371_diluted_coat_color1.37145629
46MP0000689_abnormal_spleen_morphology1.35058957
47MP0003195_calcinosis1.33465454
48MP0004883_abnormal_blood_vessel1.31644433
49MP0002722_abnormal_immune_system1.31319997
50MP0003221_abnormal_cardiomyocyte_apopto1.29848786
51MP0003436_decreased_susceptibility_to1.28287967
52MP0002429_abnormal_blood_cell1.24752956
53MP0006082_CNS_inflammation1.22369638
54MP0001845_abnormal_inflammatory_respons1.20981633
55MP0000703_abnormal_thymus_morphology1.16897270
56MP0005310_abnormal_salivary_gland1.15564877
57MP0009764_decreased_sensitivity_to1.13663894
58MP0004808_abnormal_hematopoietic_stem1.09546326
59MP0000383_abnormal_hair_follicle1.05647766
60MP0002006_tumorigenesis1.05253089
61MP0002405_respiratory_system_inflammati1.04673368
62MP0001186_pigmentation_phenotype1.01036137
63MP0003183_abnormal_peptide_metabolism1.00000064
64MP0003121_genomic_imprinting0.99089957
65MP0002168_other_aberrant_phenotype0.98474667
66MP0005464_abnormal_platelet_physiology0.97428268
67MP0005164_abnormal_response_to0.94442356
68MP0004130_abnormal_muscle_cell0.94286663
69MP0003690_abnormal_glial_cell0.93150449
70MP0010155_abnormal_intestine_physiology0.92825550
71MP0003879_abnormal_hair_cell0.91717750
72MP0003866_abnormal_defecation0.91188992
73MP0002075_abnormal_coat/hair_pigmentati0.91034154
74MP0002095_abnormal_skin_pigmentation0.89502696
75MP0004484_altered_response_of0.89434768
76MP0006054_spinal_hemorrhage0.88034727
77MP0008469_abnormal_protein_level0.87738557
78MP0005266_abnormal_metabolism0.82427042
79MP0004272_abnormal_basement_membrane0.81055401
80MP0008961_abnormal_basal_metabolism0.79166680
81MP0005397_hematopoietic_system_phenotyp0.78947680
82MP0001545_abnormal_hematopoietic_system0.78947680
83MP0010678_abnormal_skin_adnexa0.78014480
84MP0009763_increased_sensitivity_to0.77914094
85MP0004947_skin_inflammation0.77338388
86MP0000858_altered_metastatic_potential0.74172816
87MP0005670_abnormal_white_adipose0.73659710
88MP0008874_decreased_physiological_sensi0.72014231
89MP0005376_homeostasis/metabolism_phenot0.70687707
90MP0002396_abnormal_hematopoietic_system0.69983941
91MP0001533_abnormal_skeleton_physiology0.65433838
92MP0003632_abnormal_nervous_system0.63172385
93MP0004147_increased_porphyrin_level0.61443574
94MP0002971_abnormal_brown_adipose0.59511338
95MP0005584_abnormal_enzyme/coenzyme_acti0.58642492
96MP0005621_abnormal_cell_physiology0.56602291
97MP0009115_abnormal_fat_cell0.55932760
98MP0000604_amyloidosis0.55118903
99MP0000465_gastrointestinal_hemorrhage0.54265713
100MP0000249_abnormal_blood_vessel0.54016826

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)6.08309173
2Type II lissencephaly (HP:0007260)5.52028212
3Muscle hypertrophy of the lower extremities (HP:0008968)5.33796338
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.33484982
5T lymphocytopenia (HP:0005403)5.00506936
6Recurrent bacterial skin infections (HP:0005406)4.95723286
7Abnormality of T cell number (HP:0011839)4.75029766
8Gastrointestinal stroma tumor (HP:0100723)4.71422187
9Optic neuritis (HP:0100653)4.46907005
10Retrobulbar optic neuritis (HP:0100654)4.46907005
11Amelogenesis imperfecta (HP:0000705)4.46736265
12Recurrent abscess formation (HP:0002722)4.25527509
13Vasculitis (HP:0002633)4.16978545
14Spontaneous hematomas (HP:0007420)4.10824832
15Orchitis (HP:0100796)4.01187079
16Retinal dysplasia (HP:0007973)3.78836593
17Myositis (HP:0100614)3.78001133
18Recurrent fungal infections (HP:0002841)3.55299149
19Eczematoid dermatitis (HP:0000976)3.54110660
20Acanthocytosis (HP:0001927)3.50292665
21Recurrent cutaneous fungal infections (HP:0011370)3.47376688
22Chronic mucocutaneous candidiasis (HP:0002728)3.47376688
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.44195680
24Lymphopenia (HP:0001888)3.43631758
25Recurrent skin infections (HP:0001581)3.34642743
26Poikilocytosis (HP:0004447)3.26729712
27Gastrointestinal infarctions (HP:0005244)3.25944078
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.16040794
29Keratoconjunctivitis sicca (HP:0001097)3.07405597
30Colitis (HP:0002583)3.07391351
31Gingivitis (HP:0000230)3.05990582
32Conjunctival telangiectasia (HP:0000524)3.05055317
33Abnormality of the vasculature of the conjunctiva (HP:0008054)3.04560153
34Autoimmune hemolytic anemia (HP:0001890)2.93998660
35Abnormality of T cells (HP:0002843)2.91380474
36Hemoptysis (HP:0002105)2.85089636
37Recurrent viral infections (HP:0004429)2.82878911
38Keratoconjunctivitis (HP:0001096)2.81372011
39Gingival bleeding (HP:0000225)2.79243098
40Inflammation of the large intestine (HP:0002037)2.78687954
41Hematochezia (HP:0002573)2.77823539
42Arterial thrombosis (HP:0004420)2.76787564
43Postural instability (HP:0002172)2.73847507
44Stomach cancer (HP:0012126)2.68690191
45Gangrene (HP:0100758)2.65844859
46Peritonitis (HP:0002586)2.64366820
47Recurrent gram-negative bacterial infections (HP:0005420)2.62944289
48Recurrent bronchitis (HP:0002837)2.60481735
49Abnormality of the fingertips (HP:0001211)2.57898141
50Meningitis (HP:0001287)2.54074296
51Mediastinal lymphadenopathy (HP:0100721)2.54059591
52Gastrointestinal inflammation (HP:0004386)2.50272013
53Emphysema (HP:0002097)2.48362943
54Leukocytosis (HP:0001974)2.48030042
55Encephalitis (HP:0002383)2.45464814
56Elevated erythrocyte sedimentation rate (HP:0003565)2.45349582
57Pulmonary embolism (HP:0002204)2.40438293
58Thyroiditis (HP:0100646)2.37393172
59Restrictive lung disease (HP:0002091)2.32852052
60Recurrent sinusitis (HP:0011108)2.30788546
61Parakeratosis (HP:0001036)2.28576724
62Genetic anticipation (HP:0003743)2.22485131
63Abnormality of macrophages (HP:0004311)2.22291066
64IgM deficiency (HP:0002850)2.22207255
65Acute hepatic failure (HP:0006554)2.22021841
66Keratitis (HP:0000491)2.20122074
67IgG deficiency (HP:0004315)2.18487220
68IgA deficiency (HP:0002720)2.18092434
69Focal motor seizures (HP:0011153)2.16978592
70Slow saccadic eye movements (HP:0000514)2.16388890
71Stomatitis (HP:0010280)2.15845289
72Visual hallucinations (HP:0002367)2.11500562
73Abnormality of eosinophils (HP:0001879)2.09195654
74Chest pain (HP:0100749)2.07678017
75Pulmonary infiltrates (HP:0002113)2.07223155
76Obstructive lung disease (HP:0006536)2.06779802
77Chronic obstructive pulmonary disease (HP:0006510)2.06779802
78Transposition of the great arteries (HP:0001669)2.06711443
79Abnormal connection of the cardiac segments (HP:0011545)2.06711443
80Abnormal ventriculo-arterial connection (HP:0011563)2.06711443
81Abnormality of the calf musculature (HP:0001430)2.04577634
82Poikiloderma (HP:0001029)2.02148203
83Periodontitis (HP:0000704)2.01857712
84Leukopenia (HP:0001882)1.99997965
85Muscular dystrophy (HP:0003560)1.99892047
86Esophageal varix (HP:0002040)1.98251535
87Eosinophilia (HP:0001880)1.98097974
88Epistaxis (HP:0000421)1.96608805
89Anorexia (HP:0002039)1.94654980
90Abnormality of DNA repair (HP:0003254)1.94631395
91Viral hepatitis (HP:0006562)1.94227633
92Lymphoma (HP:0002665)1.92431084
93Sepsis (HP:0100806)1.91762421
94Autoimmune thrombocytopenia (HP:0001973)1.87707969
95Abnormality of T cell physiology (HP:0011840)1.86278528
96Portal hypertension (HP:0001409)1.85979494
97Porencephaly (HP:0002132)1.85953847
98Subacute progressive viral hepatitis (HP:0006572)1.82124800
99Entropion (HP:0000621)1.80608335
100Ectropion (HP:0000656)1.80483457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.53851590
2LATS15.04253484
3STK38L3.17331335
4FRK2.98510379
5RIPK42.96682181
6IRAK42.32038150
7LATS22.21257357
8BLK2.19530532
9IKBKE2.15441886
10TEC2.05513093
11NLK2.02803978
12GRK62.01358093
13TXK2.01028086
14ACVR1B2.00300245
15JAK31.86351537
16MAP4K11.79693973
17FGR1.75903478
18MAP3K21.73335620
19TAOK31.71155218
20BTK1.70171449
21SYK1.69584911
22PIK3CG1.68605539
23CSK1.62069986
24STK381.61306260
25MAP3K131.58545819
26ITK1.52953622
27BMPR21.51512910
28TYK21.48351133
29JAK11.47661719
30PTK2B1.44542069
31GRK51.41118379
32MELK1.36902545
33FES1.24382765
34FGFR31.13429536
35MATK1.12551493
36MARK21.10209517
37KSR21.09195549
38STK31.07373908
39MAP3K141.05677893
40PIM10.99725354
41PLK20.98885076
42LYN0.94720857
43GRK70.90372535
44IRAK10.86148253
45WNK10.84664044
46PDPK10.80748745
47HCK0.79622253
48MAP3K100.79084045
49JAK20.78646471
50ERBB20.78168426
51IKBKB0.76544434
52SGK20.74179130
53STK40.73342798
54MAP2K30.72429190
55FGFR40.71976863
56MARK30.71486359
57BMPR1B0.69339697
58PRKAA20.66130282
59MAP3K10.65804249
60TGFBR20.64638965
61KIT0.63829755
62CHUK0.63705791
63IRAK20.63351258
64LCK0.63341154
65MOS0.62265643
66MAP2K20.61852668
67KSR10.61838038
68MAP2K60.61251511
69LRRK20.60930466
70CDK120.59997219
71MAPK110.59670950
72DYRK1A0.59463604
73ADRBK20.59369799
74ADRBK10.58844181
75PDK10.58418266
76ZAP700.57394676
77TRPM70.55536032
78MAP3K70.54820186
79MAP3K60.54263597
80RPS6KB10.52533890
81TBK10.49253062
82CDC42BPA0.49151227
83STK110.48636508
84EIF2AK20.48540386
85NEK90.46254371
86CSF1R0.46174688
87SIK30.41412949
88PRKD10.39101115
89STK100.39051334
90EGFR0.36334688
91MAPK70.35798713
92SGK10.35233605
93RAF10.34457104
94SGK30.34177850
95PRKCZ0.33245762
96DAPK20.31335609
97DYRK30.31151528
98ABL10.29697912
99SGK2230.29273917
100SGK4940.29273917

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.77314757
2Dorso-ventral axis formation_Homo sapiens_hsa043202.30362205
3Hematopoietic cell lineage_Homo sapiens_hsa046402.27951138
4B cell receptor signaling pathway_Homo sapiens_hsa046622.21532131
5Graft-versus-host disease_Homo sapiens_hsa053322.20859337
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.18499649
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16317678
8Osteoclast differentiation_Homo sapiens_hsa043802.07448364
9Primary immunodeficiency_Homo sapiens_hsa053401.99908814
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.98818811
11Staphylococcus aureus infection_Homo sapiens_hsa051501.98540270
12Allograft rejection_Homo sapiens_hsa053301.97705894
13Autoimmune thyroid disease_Homo sapiens_hsa053201.93045219
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92363070
15Tuberculosis_Homo sapiens_hsa051521.89322833
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78693303
17Pentose phosphate pathway_Homo sapiens_hsa000301.74881738
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74692435
19Asthma_Homo sapiens_hsa053101.74108382
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68589256
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67762859
22Measles_Homo sapiens_hsa051621.64171362
23Influenza A_Homo sapiens_hsa051641.61580979
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58617494
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.43781406
26T cell receptor signaling pathway_Homo sapiens_hsa046601.42450338
27Toxoplasmosis_Homo sapiens_hsa051451.41329511
28Type I diabetes mellitus_Homo sapiens_hsa049401.39395444
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34904961
30Legionellosis_Homo sapiens_hsa051341.32914524
31Herpes simplex infection_Homo sapiens_hsa051681.31962371
32Viral myocarditis_Homo sapiens_hsa054161.29804998
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26850668
34Non-small cell lung cancer_Homo sapiens_hsa052231.24490351
35TNF signaling pathway_Homo sapiens_hsa046681.19717976
36Hepatitis B_Homo sapiens_hsa051611.17242010
37Antigen processing and presentation_Homo sapiens_hsa046121.12860034
38Chemokine signaling pathway_Homo sapiens_hsa040621.10816166
39Malaria_Homo sapiens_hsa051441.10466366
40Phototransduction_Homo sapiens_hsa047441.10454024
41Hepatitis C_Homo sapiens_hsa051601.08999070
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04889164
43Prolactin signaling pathway_Homo sapiens_hsa049171.03620477
44VEGF signaling pathway_Homo sapiens_hsa043701.03434971
45Acute myeloid leukemia_Homo sapiens_hsa052211.01506598
46Pancreatic cancer_Homo sapiens_hsa052120.99998549
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.98888041
48Notch signaling pathway_Homo sapiens_hsa043300.93267287
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91165108
50Platelet activation_Homo sapiens_hsa046110.90599953
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.88541201
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85766879
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81637008
54FoxO signaling pathway_Homo sapiens_hsa040680.79729828
55Rheumatoid arthritis_Homo sapiens_hsa053230.79530927
56Olfactory transduction_Homo sapiens_hsa047400.78624170
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77542226
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72998000
59Pertussis_Homo sapiens_hsa051330.71496552
60Sphingolipid metabolism_Homo sapiens_hsa006000.70238924
61Apoptosis_Homo sapiens_hsa042100.69978294
62Phagosome_Homo sapiens_hsa041450.69385384
63Inositol phosphate metabolism_Homo sapiens_hsa005620.69184240
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65950343
65African trypanosomiasis_Homo sapiens_hsa051430.64026948
66Chronic myeloid leukemia_Homo sapiens_hsa052200.63621742
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62715860
68Endometrial cancer_Homo sapiens_hsa052130.61581501
69Taste transduction_Homo sapiens_hsa047420.60631779
70Fatty acid biosynthesis_Homo sapiens_hsa000610.59133257
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.58200336
72ABC transporters_Homo sapiens_hsa020100.56806907
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55972846
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55715790
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.55402870
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55172154
77HTLV-I infection_Homo sapiens_hsa051660.55113044
78Renal cell carcinoma_Homo sapiens_hsa052110.54410806
79Epstein-Barr virus infection_Homo sapiens_hsa051690.53328600
80Lysine degradation_Homo sapiens_hsa003100.52659711
81Glioma_Homo sapiens_hsa052140.51306728
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46911087
83Morphine addiction_Homo sapiens_hsa050320.46668655
84Viral carcinogenesis_Homo sapiens_hsa052030.45889477
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45590791
86Nicotine addiction_Homo sapiens_hsa050330.44217354
87Long-term potentiation_Homo sapiens_hsa047200.44047785
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43543392
89Calcium signaling pathway_Homo sapiens_hsa040200.41330649
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.39462983
91mTOR signaling pathway_Homo sapiens_hsa041500.39438486
92HIF-1 signaling pathway_Homo sapiens_hsa040660.38668006
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38057155
94Choline metabolism in cancer_Homo sapiens_hsa052310.37561857
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35513345
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35140019
97Colorectal cancer_Homo sapiens_hsa052100.34971367
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34773102
99ErbB signaling pathway_Homo sapiens_hsa040120.33896979
100Thyroid cancer_Homo sapiens_hsa052160.33237528

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