ZDHHC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.66958227
2COPI coating of Golgi vesicle (GO:0048205)4.66958227
3fusion of sperm to egg plasma membrane (GO:0007342)4.42766125
4sperm motility (GO:0030317)4.16192406
5cell wall macromolecule metabolic process (GO:0044036)4.03547750
6cell wall macromolecule catabolic process (GO:0016998)4.03547750
7carnitine transport (GO:0015879)3.76437493
8amino-acid betaine transport (GO:0015838)3.76437493
9alpha-linolenic acid metabolic process (GO:0036109)3.74459835
10fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73590711
11carnitine transmembrane transport (GO:1902603)3.68824054
12lysine metabolic process (GO:0006553)3.66036731
13lysine catabolic process (GO:0006554)3.66036731
14sperm-egg recognition (GO:0035036)3.64808924
15low-density lipoprotein particle clearance (GO:0034383)3.61333896
16regulation of fatty acid beta-oxidation (GO:0031998)3.53780032
17regulation of cholesterol homeostasis (GO:2000188)3.49331427
18acrosome assembly (GO:0001675)3.48932887
19positive regulation of fatty acid beta-oxidation (GO:0032000)3.42157136
20urea cycle (GO:0000050)3.40140061
21urea metabolic process (GO:0019627)3.40140061
22pinocytosis (GO:0006907)3.36216727
23carnitine shuttle (GO:0006853)3.35887329
24cell-cell recognition (GO:0009988)3.34921159
25cell adhesion mediated by integrin (GO:0033627)3.34787770
26fatty acid transmembrane transport (GO:1902001)3.34286785
27binding of sperm to zona pellucida (GO:0007339)3.32574715
28hypotonic response (GO:0006971)3.30954403
29regulation of early endosome to late endosome transport (GO:2000641)3.28778397
30barbed-end actin filament capping (GO:0051016)3.26882379
31multicellular organism reproduction (GO:0032504)3.22719546
32stress fiber assembly (GO:0043149)3.22575887
33protein localization to endosome (GO:0036010)3.22307016
34plasma membrane fusion (GO:0045026)3.22236055
35skin morphogenesis (GO:0043589)3.20656986
36focal adhesion assembly (GO:0048041)3.16860834
37cell-substrate adherens junction assembly (GO:0007045)3.16860834
384-hydroxyproline metabolic process (GO:0019471)3.16802811
39embryonic process involved in female pregnancy (GO:0060136)3.15270269
40epithelial cell-cell adhesion (GO:0090136)3.14040513
41adherens junction assembly (GO:0034333)3.12948533
42synaptonemal complex assembly (GO:0007130)3.10367525
43amino-acid betaine metabolic process (GO:0006577)3.09513235
44positive regulation of Cdc42 GTPase activity (GO:0043089)3.06580328
45organic cation transport (GO:0015695)3.06562742
46response to laminar fluid shear stress (GO:0034616)3.05702316
47negative regulation of fibrinolysis (GO:0051918)3.04464235
48positive regulation of histone deacetylation (GO:0031065)3.03333637
49reproduction (GO:0000003)3.02970298
50cilium or flagellum-dependent cell motility (GO:0001539)3.02541665
51synaptonemal complex organization (GO:0070193)3.01239777
52cysteine metabolic process (GO:0006534)2.99637355
53quaternary ammonium group transport (GO:0015697)2.95444460
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94897604
55nitrogen cycle metabolic process (GO:0071941)2.93715852
56spermatid development (GO:0007286)2.93542881
57positive regulation of glycolytic process (GO:0045821)2.93223478
58acrosome reaction (GO:0007340)2.92617472
59sulfur amino acid catabolic process (GO:0000098)2.92316561
602-oxoglutarate metabolic process (GO:0006103)2.92158430
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91312024
62cytoskeletal anchoring at plasma membrane (GO:0007016)2.89358067
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89332931
64carnitine metabolic process (GO:0009437)2.88293463
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86311888
66hemidesmosome assembly (GO:0031581)2.85729992
67negative regulation of erythrocyte differentiation (GO:0045647)2.85082041
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83709240
69kynurenine metabolic process (GO:0070189)2.82968372
70activation of Rac GTPase activity (GO:0032863)2.82296273
71protein retention in ER lumen (GO:0006621)2.79978911
72piRNA metabolic process (GO:0034587)2.79508426
73aspartate family amino acid catabolic process (GO:0009068)2.78983870
74regulation of triglyceride catabolic process (GO:0010896)2.78645201
75plasma lipoprotein particle clearance (GO:0034381)2.78503580
76homocysteine metabolic process (GO:0050667)2.78106899
77regulation of fatty acid oxidation (GO:0046320)2.76752127
78complement activation, alternative pathway (GO:0006957)2.75579488
79peptidyl-glutamic acid carboxylation (GO:0017187)2.75192497
80protein carboxylation (GO:0018214)2.75192497
81positive regulation of lipid catabolic process (GO:0050996)2.74909928
82NLS-bearing protein import into nucleus (GO:0006607)2.74764944
83basement membrane organization (GO:0071711)2.74387861
84positive regulation of fatty acid oxidation (GO:0046321)2.73511755
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73086470
86membrane raft organization (GO:0031579)2.72954985
87nuclear pore complex assembly (GO:0051292)2.72088587
88hormone catabolic process (GO:0042447)2.71252320
89macroautophagy (GO:0016236)2.71171887
90mannose metabolic process (GO:0006013)2.70047109
91regulation of water loss via skin (GO:0033561)2.69391775
92bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66207498
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64676734
94motile cilium assembly (GO:0044458)2.62751719
95epoxygenase P450 pathway (GO:0019373)2.62077800
96male meiosis (GO:0007140)2.61907143
97COPII vesicle coating (GO:0048208)2.60526023
98dicarboxylic acid biosynthetic process (GO:0043650)2.60016371
99glyoxylate metabolic process (GO:0046487)2.59560194
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.58842008
101cell-substrate junction assembly (GO:0007044)2.58537307
102regulation of cholesterol storage (GO:0010885)2.58141638
103endodermal cell differentiation (GO:0035987)2.58120713
104plasma membrane repair (GO:0001778)2.57985445
105positive regulation of lipid storage (GO:0010884)2.57960047
106fatty acid beta-oxidation (GO:0006635)2.57303506
107regulation of protein activation cascade (GO:2000257)2.57085261
108membrane protein ectodomain proteolysis (GO:0006509)2.56948766
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55353186
110L-phenylalanine catabolic process (GO:0006559)2.55353186
111negative regulation of cell size (GO:0045792)2.54840404
112phospholipid homeostasis (GO:0055091)2.53495098
113positive regulation of triglyceride metabolic process (GO:0090208)2.52656168
114positive regulation of receptor recycling (GO:0001921)2.52192830
115branching involved in mammary gland duct morphogenesis (GO:0060444)2.51316359
116surfactant homeostasis (GO:0043129)2.51193624
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.50999179
118L-phenylalanine metabolic process (GO:0006558)2.50999179
119positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50601927
120activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50566752
121negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.49495296
122vesicle coating (GO:0006901)2.49386570
123apoptotic cell clearance (GO:0043277)2.49342717
124regulation of complement activation (GO:0030449)2.48488304
125iron ion import (GO:0097286)2.48249848
126negative regulation of protein localization to plasma membrane (GO:1903077)2.47923458
127dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46956075
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46904407
129regulation of fibrinolysis (GO:0051917)2.45034687
130cytoplasmic mRNA processing body assembly (GO:0033962)2.44933810
131mammary gland epithelial cell proliferation (GO:0033598)2.44636270
132negative regulation of fatty acid transport (GO:2000192)2.44464907
133desmosome organization (GO:0002934)2.42979682
134negative regulation of sterol transport (GO:0032372)2.42596264
135negative regulation of cholesterol transport (GO:0032375)2.42596264
136growth hormone receptor signaling pathway (GO:0060396)2.42509024
137apoptotic process involved in morphogenesis (GO:0060561)2.41092144
138mitotic sister chromatid cohesion (GO:0007064)2.40681354
139positive regulation of nuclease activity (GO:0032075)2.40599757
140regulation of sequestering of triglyceride (GO:0010889)2.40489958
141fatty acid oxidation (GO:0019395)2.40242313
142negative regulation of anoikis (GO:2000811)2.39671215
143negative regulation of lipid transport (GO:0032369)2.39299766
144modulation by symbiont of host cellular process (GO:0044068)2.39105486
145maternal placenta development (GO:0001893)2.38812470
146hyaluronan catabolic process (GO:0030214)2.38303962
147positive regulation of keratinocyte differentiation (GO:0045618)2.38294329
148regulation of transforming growth factor beta1 production (GO:0032908)2.38283929
149endoplasmic reticulum unfolded protein response (GO:0030968)2.37871094
150valine metabolic process (GO:0006573)2.37576749
151cellular response to arsenic-containing substance (GO:0071243)2.36245170
152regulation of extracellular matrix disassembly (GO:0010715)2.35172819
153regulation of vitamin D biosynthetic process (GO:0060556)2.35017329
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33251901
155response to peptidoglycan (GO:0032494)2.32860061
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.30935193
157ER-nucleus signaling pathway (GO:0006984)2.30568253
158pentose-phosphate shunt (GO:0006098)2.29835711
159negative regulation of viral release from host cell (GO:1902187)2.29421022
160regulation of NFAT protein import into nucleus (GO:0051532)2.28369194
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27021077
162cortical actin cytoskeleton organization (GO:0030866)2.27015716
163proline biosynthetic process (GO:0006561)2.26140687
164vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25802814
165positive regulation of extracellular matrix organization (GO:1903055)2.25642874
166regulation of integrin activation (GO:0033623)2.25525563
167lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24784161
168glycosphingolipid catabolic process (GO:0046479)2.24539127
169antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.22745302
170regulation of anoikis (GO:2000209)2.22097116
1713-UTR-mediated mRNA stabilization (GO:0070935)2.21977965
172regulation of vitamin metabolic process (GO:0030656)2.21763818
173semaphorin-plexin signaling pathway (GO:0071526)2.21062922
174regulation of nuclease activity (GO:0032069)2.19203818
175regulation of necroptotic process (GO:0060544)2.19017209
176NIK/NF-kappaB signaling (GO:0038061)2.18635865
177antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.18633038
178negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17983202
179cellular response to unfolded protein (GO:0034620)2.17621711
180mesodermal cell differentiation (GO:0048333)2.16038253
181decidualization (GO:0046697)2.15804063
182negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.15513513
183endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15195172
184regulation of apoptotic process involved in morphogenesis (GO:1902337)2.14863806
185negative regulation of necroptotic process (GO:0060546)2.14546610
186regulation of nucleobase-containing compound transport (GO:0032239)2.14367745
187response to muramyl dipeptide (GO:0032495)2.13979117
188substrate-dependent cell migration (GO:0006929)2.13853688
189establishment of skin barrier (GO:0061436)2.13428341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.98522457
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.76200811
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.66910298
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.60222422
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.40261564
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17644198
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12297473
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.08213688
9ZNF263_19887448_ChIP-Seq_K562_Human2.45256438
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43220505
11CLOCK_20551151_ChIP-Seq_293T_Human2.22305771
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20946115
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19055220
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17004425
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06655133
16* VDR_21846776_ChIP-Seq_THP-1_Human2.04050980
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97971168
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96936501
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.75388063
20TCF7_22412390_ChIP-Seq_EML_Mouse1.73260449
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73027583
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72463387
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69938003
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67713738
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.67184891
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.67184891
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65290355
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.63747742
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61047218
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60965375
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60343821
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55564760
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54008159
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53658857
35E2F7_22180533_ChIP-Seq_HELA_Human1.53185233
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.51201640
37VDR_24763502_ChIP-Seq_THP-1_Human1.50373137
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47321619
39ATF3_27146783_Chip-Seq_COLON_Human1.46147026
40KDM2B_26808549_Chip-Seq_DND41_Human1.45310230
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44033421
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.43910944
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40450616
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40396457
45* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39987085
46MYC_22102868_ChIP-Seq_BL_Human1.39870727
47GATA6_25053715_ChIP-Seq_YYC3_Human1.37285844
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36303887
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36283403
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35461412
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33697938
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.33397148
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.32928033
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.32692402
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32646704
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32386532
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32258275
58* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31609655
59RACK7_27058665_Chip-Seq_MCF-7_Human1.31347356
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29710112
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28811994
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.28327462
63LXR_22292898_ChIP-Seq_THP-1_Human1.25957209
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24607546
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23015198
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22274056
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18432309
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.18392311
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18014668
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17990073
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14160950
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.12494834
73NCOR1_26117541_ChIP-Seq_K562_Human1.11603127
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11550217
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.09719632
76* GATA4_25053715_ChIP-Seq_YYC3_Human1.09286868
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09146200
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08618982
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.08276036
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08095269
81* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07962225
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07571161
83* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07440784
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07367610
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07349117
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06108383
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06076539
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05881822
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.05167396
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04694529
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04106590
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03646584
93* UTX_26944678_Chip-Seq_JUKART_Human1.03290424
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01971656
95MAF_26560356_Chip-Seq_TH1_Human1.01373296
96* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00844321
97* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00844321
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00638250
99SPI1_23127762_ChIP-Seq_K562_Human0.98594238
100TFEB_21752829_ChIP-Seq_HELA_Human0.97375503
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97091799
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97003933
103TP53_22127205_ChIP-Seq_IMR90_Human0.96949287
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96345306
105CREB1_26743006_Chip-Seq_LNCaP_Human0.96146239
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95966550
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95933924
108AR_21909140_ChIP-Seq_LNCAP_Human0.95853629
109CJUN_26792858_Chip-Seq_BT549_Human0.95742729
110KDM2B_26808549_Chip-Seq_JURKAT_Human0.95707276
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95174364
112* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95062581
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94939798
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94110916
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93927610
116TP63_22573176_ChIP-Seq_HFKS_Human0.93620929
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93041087
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92596714
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92418540
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91305376
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90836535
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89958485
123KDM2B_26808549_Chip-Seq_K562_Human0.89137430
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88963481
125GATA2_19941826_ChIP-Seq_K562_Human0.87764561
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86535077
127GATA1_19941826_ChIP-Seq_K562_Human0.86383063
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86130534
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85991559
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84541619
131* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84489611
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84005978
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83966004
134BCOR_27268052_Chip-Seq_Bcells_Human0.83917290
135ELF1_20517297_ChIP-Seq_JURKAT_Human0.82357926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.29848284
2MP0005360_urolithiasis3.62764775
3MP0005410_abnormal_fertilization3.51905049
4MP0002139_abnormal_hepatobiliary_system3.43491052
5MP0005365_abnormal_bile_salt2.44983593
6MP0010352_gastrointestinal_tract_polyps2.38932895
7MP0003252_abnormal_bile_duct2.34062678
8MP0005085_abnormal_gallbladder_physiolo2.33233146
9MP0005275_abnormal_skin_tensile2.31152901
10MP0010234_abnormal_vibrissa_follicle2.25284225
11MP0003300_gastrointestinal_ulcer2.23789692
12MP0008438_abnormal_cutaneous_collagen2.14290970
13MP0005058_abnormal_lysosome_morphology2.13621087
14MP0003436_decreased_susceptibility_to1.82950608
15MP0003566_abnormal_cell_adhesion1.82913291
16MP0004185_abnormal_adipocyte_glucose1.79712786
17MP0002796_impaired_skin_barrier1.74937145
18MP0008875_abnormal_xenobiotic_pharmacok1.74579181
19MP0008260_abnormal_autophagy1.73904288
20MP0005666_abnormal_adipose_tissue1.72846528
21MP0005076_abnormal_cell_differentiation1.69060448
22MP0009840_abnormal_foam_cell1.64991614
23MP0005409_darkened_coat_color1.63500094
24MP0010329_abnormal_lipoprotein_level1.63446525
25MP0000858_altered_metastatic_potential1.63079687
26MP0003011_delayed_dark_adaptation1.54988627
27MP0005670_abnormal_white_adipose1.52795060
28MP0004130_abnormal_muscle_cell1.46078588
29MP0004084_abnormal_cardiac_muscle1.39910355
30MP0003191_abnormal_cellular_cholesterol1.38457100
31MP0003646_muscle_fatigue1.34979828
32MP0003941_abnormal_skin_development1.34889525
33MP0000609_abnormal_liver_physiology1.34724688
34MP0005023_abnormal_wound_healing1.33623639
35MP0004858_abnormal_nervous_system1.30050049
36MP0004087_abnormal_muscle_fiber1.29369456
37MP0005623_abnormal_meninges_morphology1.26555640
38MP0002837_dystrophic_cardiac_calcinosis1.26478631
39MP0002060_abnormal_skin_morphology1.25989752
40MP0006054_spinal_hemorrhage1.24960833
41MP0005083_abnormal_biliary_tract1.24532319
42MP0003828_pulmonary_edema1.23278777
43MP0005375_adipose_tissue_phenotype1.20967821
44MP0001666_abnormal_nutrient_absorption1.20781643
45MP0010630_abnormal_cardiac_muscle1.18086492
46MP0003448_altered_tumor_morphology1.17087575
47MP0001849_ear_inflammation1.16948999
48MP0002998_abnormal_bone_remodeling1.16936780
49MP0002877_abnormal_melanocyte_morpholog1.15647158
50MP0004510_myositis1.15499312
51MP0000733_abnormal_muscle_development1.14827935
52MP0003172_abnormal_lysosome_physiology1.12218410
53MP0004019_abnormal_vitamin_homeostasis1.10913493
54MP0003303_peritoneal_inflammation1.10775879
55MP0009053_abnormal_anal_canal1.10366402
56MP0003045_fibrosis1.10115259
57MP0004947_skin_inflammation1.08763149
58MP0005501_abnormal_skin_physiology1.07300223
59MP0001533_abnormal_skeleton_physiology1.06778120
60MP0005319_abnormal_enzyme/_coenzyme1.06344218
61MP0008961_abnormal_basal_metabolism1.06220863
62MP0004233_abnormal_muscle_weight1.05616617
63MP0002138_abnormal_hepatobiliary_system1.05229211
64MP0000750_abnormal_muscle_regeneration1.05152434
65MP0000751_myopathy1.04378880
66MP0000767_abnormal_smooth_muscle1.03391448
67MP0003453_abnormal_keratinocyte_physiol1.02386872
68MP0009278_abnormal_bone_marrow1.02267814
69MP0002269_muscular_atrophy1.01242909
70MP0004264_abnormal_extraembryonic_tissu1.01128706
71MP0010307_abnormal_tumor_latency1.00766189
72MP0005621_abnormal_cell_physiology0.98930725
73MP0000467_abnormal_esophagus_morphology0.98644763
74MP0002419_abnormal_innate_immunity0.97649027
75MP0001929_abnormal_gametogenesis0.96984290
76MP0010368_abnormal_lymphatic_system0.96860717
77MP0004036_abnormal_muscle_relaxation0.96769625
78MP0010155_abnormal_intestine_physiology0.96652252
79MP0004272_abnormal_basement_membrane0.96559814
80MP0002118_abnormal_lipid_homeostasis0.96556674
81MP0004808_abnormal_hematopoietic_stem0.95822882
82MP0005332_abnormal_amino_acid0.95623788
83MP0003806_abnormal_nucleotide_metabolis0.94677941
84MP0003698_abnormal_male_reproductive0.94597946
85MP0003279_aneurysm0.94560988
86MP0009384_cardiac_valve_regurgitation0.93228860
87MP0003763_abnormal_thymus_physiology0.93070187
88MP0000685_abnormal_immune_system0.92497731
89MP0003091_abnormal_cell_migration0.91770060
90MP0005464_abnormal_platelet_physiology0.91570915
91MP0002971_abnormal_brown_adipose0.91133702
92MP0005330_cardiomyopathy0.90744410
93MP0001348_abnormal_lacrimal_gland0.89567516
94MP0001216_abnormal_epidermal_layer0.88545666
95MP0001851_eye_inflammation0.87645357
96MP0003075_altered_response_to0.87338682
97MP0009333_abnormal_splenocyte_physiolog0.87145747
98MP0005164_abnormal_response_to0.86714175
99MP0002098_abnormal_vibrissa_morphology0.85253446
100MP0002166_altered_tumor_susceptibility0.84724579
101MP0000678_abnormal_parathyroid_gland0.84065526
102MP0000490_abnormal_crypts_of0.83948693
103MP0009643_abnormal_urine_homeostasis0.83509571
104MP0002396_abnormal_hematopoietic_system0.82385342
105MP0005025_abnormal_response_to0.81955490
106MP0005000_abnormal_immune_tolerance0.81454722
107MP0001958_emphysema0.81420922
108MP0002168_other_aberrant_phenotype0.79847342
109MP0005165_increased_susceptibility_to0.79753824
110MP0001730_embryonic_growth_arrest0.79497678
111MP0001835_abnormal_antigen_presentation0.79464498
112MP0000377_abnormal_hair_follicle0.79387693
113MP0001853_heart_inflammation0.79200228
114MP0000598_abnormal_liver_morphology0.79015311
115MP0003656_abnormal_erythrocyte_physiolo0.78621454
116MP0003329_amyloid_beta_deposits0.78546910
117MP0004782_abnormal_surfactant_physiolog0.78541098
118MP0000762_abnormal_tongue_morphology0.78251457
119MP0000579_abnormal_nail_morphology0.78037184
120MP0003115_abnormal_respiratory_system0.77447782
121MP0003950_abnormal_plasma_membrane0.76574452
122MP0002254_reproductive_system_inflammat0.75519252
123MP0005387_immune_system_phenotype0.74713484
124MP0001790_abnormal_immune_system0.74713484
125MP0002089_abnormal_postnatal_growth/wei0.74521497
126MP0000627_abnormal_mammary_gland0.73610221
127MP0005451_abnormal_body_composition0.73607409
128MP0002006_tumorigenesis0.73291441
129MP0009115_abnormal_fat_cell0.73032494
130MP0002088_abnormal_embryonic_growth/wei0.72913860
131MP0010678_abnormal_skin_adnexa0.72797232
132MP0006138_congestive_heart_failure0.72453090
133MP0002086_abnormal_extraembryonic_tissu0.72360226
134MP0003984_embryonic_growth_retardation0.72053840
135MP0005385_cardiovascular_system_phenoty0.71974643
136MP0001544_abnormal_cardiovascular_syste0.71974643
137MP0000537_abnormal_urethra_morphology0.71971274
138MP0002896_abnormal_bone_mineralization0.71189398
139MP0000604_amyloidosis0.70883077
140MP0004197_abnormal_fetal_growth/weight/0.70828875
141MP0000343_altered_response_to0.70635861
142MP0009672_abnormal_birth_weight0.70554431
143MP0000003_abnormal_adipose_tissue0.70523930
144MP0002148_abnormal_hypersensitivity_rea0.70501900
145MP0010771_integument_phenotype0.69966380
146MP0001915_intracranial_hemorrhage0.69649159
147MP0008775_abnormal_heart_ventricle0.69083333
148MP0001243_abnormal_dermal_layer0.68949779
149MP0002282_abnormal_trachea_morphology0.68115171
150MP0005257_abnormal_intraocular_pressure0.67734162
151MP0009931_abnormal_skin_appearance0.67479817
152MP0002128_abnormal_blood_circulation0.66532236
153MP0003195_calcinosis0.66144775
154MP0000759_abnormal_skeletal_muscle0.65345252

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.73970929
2Deep venous thrombosis (HP:0002625)3.65808121
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44630659
4Nasal polyposis (HP:0100582)3.37506729
5Increased connective tissue (HP:0009025)3.28144950
6Hyporeflexia of lower limbs (HP:0002600)3.28096665
7Protrusio acetabuli (HP:0003179)3.21622271
8Xanthomatosis (HP:0000991)3.07624839
9Abnormality of the nasal mucosa (HP:0000433)2.99574914
10Cerebral aneurysm (HP:0004944)2.85830215
11Hypoalphalipoproteinemia (HP:0003233)2.83408438
12Vertebral compression fractures (HP:0002953)2.83203254
13Difficulty climbing stairs (HP:0003551)2.78607382
14Exercise-induced muscle cramps (HP:0003710)2.77063586
15Dynein arm defect of respiratory motile cilia (HP:0012255)2.73100399
16Absent/shortened dynein arms (HP:0200106)2.73100399
17Premature rupture of membranes (HP:0001788)2.71650894
18Myocardial infarction (HP:0001658)2.71123593
19Intrahepatic cholestasis (HP:0001406)2.68930647
20Distal lower limb amyotrophy (HP:0008944)2.68467273
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65832536
22Myoglobinuria (HP:0002913)2.62993802
23Flat acetabular roof (HP:0003180)2.62472902
24Complement deficiency (HP:0004431)2.55876097
25Fragile skin (HP:0001030)2.55183033
26Distal lower limb muscle weakness (HP:0009053)2.53576550
27Broad face (HP:0000283)2.43531091
28Cardiovascular calcification (HP:0011915)2.43476680
29Asymmetric septal hypertrophy (HP:0001670)2.43106627
30Arterial tortuosity (HP:0005116)2.38834765
31Peritonitis (HP:0002586)2.37419904
32Aortic aneurysm (HP:0004942)2.37390381
33Abnormality of the lower motor neuron (HP:0002366)2.37382859
34Difficulty running (HP:0009046)2.36742388
35Mitral valve prolapse (HP:0001634)2.36479579
36Chronic bronchitis (HP:0004469)2.36002917
37Aneurysm (HP:0002617)2.35239594
38Hypolipoproteinemia (HP:0010981)2.34200463
39Vascular tortuosity (HP:0004948)2.33065697
40Hyperacusis (HP:0010780)2.32268942
41Ventricular tachycardia (HP:0004756)2.32241500
42Ankle contracture (HP:0006466)2.32236401
43Exercise-induced myalgia (HP:0003738)2.30983499
44Ketosis (HP:0001946)2.30393836
45Vascular calcification (HP:0004934)2.29139598
46Ankyloglossia (HP:0010296)2.29037021
47Muscle fiber splitting (HP:0003555)2.28733233
48Epidermoid cyst (HP:0200040)2.28472761
49Thick nail (HP:0001805)2.27259758
50Male infertility (HP:0003251)2.27131067
51Abnormality of the Achilles tendon (HP:0005109)2.25941843
52Thin bony cortex (HP:0002753)2.25328053
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19689121
54Pigmentary retinal degeneration (HP:0001146)2.17459126
55Eczematoid dermatitis (HP:0000976)2.17426496
56Infertility (HP:0000789)2.16865870
57Lymphangioma (HP:0100764)2.16235291
58Upper limb amyotrophy (HP:0009129)2.15666359
59Distal upper limb amyotrophy (HP:0007149)2.15666359
60Abnormality of oral frenula (HP:0000190)2.14355747
61Interstitial pulmonary disease (HP:0006530)2.14329329
62Sudden death (HP:0001699)2.13949361
63Hyperammonemia (HP:0001987)2.13894972
64Rhabdomyolysis (HP:0003201)2.13234967
65Hemorrhage of the eye (HP:0011885)2.12859586
66Abnormality of the distal phalanges of the toes (HP:0010182)2.12367218
67Natal tooth (HP:0000695)2.12333813
68Type 1 muscle fiber predominance (HP:0003803)2.12303964
69Abnormality of complement system (HP:0005339)2.12174094
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.11522864
71Abnormality of liposaccharide metabolism (HP:0010968)2.11412709
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.11412709
73Abnormality of glycolipid metabolism (HP:0010969)2.11412709
74Short nail (HP:0001799)2.10671103
75Spinal rigidity (HP:0003306)2.09892848
76Abnormality of nail color (HP:0100643)2.09563725
77Atrophic scars (HP:0001075)2.08109590
78Advanced eruption of teeth (HP:0006288)2.06365739
79Hand muscle atrophy (HP:0009130)2.06201657
80Polycythemia (HP:0001901)2.06054697
81Wormian bones (HP:0002645)2.05080424
82Shallow orbits (HP:0000586)2.04142196
83Achilles tendon contracture (HP:0001771)2.04004152
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03069522
85Hypercholesterolemia (HP:0003124)1.99242035
86Cholecystitis (HP:0001082)1.99171050
87Abnormal gallbladder physiology (HP:0012438)1.99171050
88Esophageal varix (HP:0002040)1.98950816
89Blue sclerae (HP:0000592)1.98567538
90Ketoacidosis (HP:0001993)1.98140193
91Subcapsular cataract (HP:0000523)1.97870413
92Increased variability in muscle fiber diameter (HP:0003557)1.97157253
93Aortic dissection (HP:0002647)1.95800014
94Abnormality of skeletal muscle fiber size (HP:0012084)1.95189267
95Osteolytic defects of the hand bones (HP:0009699)1.94310561
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.94310561
97Long toe (HP:0010511)1.93926453
98Hypobetalipoproteinemia (HP:0003563)1.93881248
99Spondylolisthesis (HP:0003302)1.92246394
100Subacute progressive viral hepatitis (HP:0006572)1.91676218
101Rectal prolapse (HP:0002035)1.91634512
102Onycholysis (HP:0001806)1.90546447
103Abnormality of the common coagulation pathway (HP:0010990)1.90070967
104Disproportionate tall stature (HP:0001519)1.89998016
105Abnormality of purine metabolism (HP:0004352)1.89967619
106Genu recurvatum (HP:0002816)1.86674126
107Mildly elevated creatine phosphokinase (HP:0008180)1.86167614
108Hyperglycinuria (HP:0003108)1.85617031
109Hypoglycemic coma (HP:0001325)1.85466908
110Cerebral inclusion bodies (HP:0100314)1.84178915
111Dysostosis multiplex (HP:0000943)1.83847929
112Skin nodule (HP:0200036)1.83101516
113Gout (HP:0001997)1.81322233
114Plantar hyperkeratosis (HP:0007556)1.81319076
115Trismus (HP:0000211)1.80815575
116Broad metatarsal (HP:0001783)1.80505484
117Nail dystrophy (HP:0008404)1.79498986
118Alopecia of scalp (HP:0002293)1.78939586
119Lower limb amyotrophy (HP:0007210)1.78855037
120Elbow flexion contracture (HP:0002987)1.78811963
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.78549146
122Increased IgE level (HP:0003212)1.77933974
123Abnormality of carpal bone ossification (HP:0006257)1.77800866
124Heterotopia (HP:0002282)1.77551915
125Reticulocytosis (HP:0001923)1.76591533
126Frequent falls (HP:0002359)1.75895109
127Asymmetry of the thorax (HP:0001555)1.75799091
128Dilatation of the ascending aorta (HP:0005111)1.75290727
129Dysmetric saccades (HP:0000641)1.74954782
130Abnormal ossification of hand bones (HP:0005921)1.74854102
131Ulnar bowing (HP:0003031)1.74284964
132Hyperlipoproteinemia (HP:0010980)1.74034898
133Spinal cord lesions (HP:0100561)1.73565705
134Syringomyelia (HP:0003396)1.73565705
135Hepatocellular carcinoma (HP:0001402)1.73310387
136Cervical subluxation (HP:0003308)1.73299807
137Cholelithiasis (HP:0001081)1.73214939
138Milia (HP:0001056)1.73167446
139Ridged nail (HP:0001807)1.72961465
140Increased density of long bones (HP:0006392)1.72822467
141Bone pain (HP:0002653)1.72605167
142Loss of speech (HP:0002371)1.71749964
143Long palpebral fissure (HP:0000637)1.71681954
144Bladder diverticulum (HP:0000015)1.71167212
145Back pain (HP:0003418)1.70739282
146Bundle branch block (HP:0011710)1.70000966
147Abnormality of macrophages (HP:0004311)1.69426557
148Cellulitis (HP:0100658)1.67235775
149Selective tooth agenesis (HP:0001592)1.66996154
150Abnormal cartilage morphology (HP:0002763)1.66475774
151Ulnar deviation of the wrist (HP:0003049)1.65488283
152Malnutrition (HP:0004395)1.65382942
153Spastic diplegia (HP:0001264)1.65265927
154Urinary glycosaminoglycan excretion (HP:0003541)1.64481735
155Mucopolysacchariduria (HP:0008155)1.64481735
156Axonal loss (HP:0003447)1.63899245
157Abnormal blistering of the skin (HP:0008066)1.63603623
158Coxa vara (HP:0002812)1.60250937
159Fragile nails (HP:0001808)1.59420961
160Mitral regurgitation (HP:0001653)1.59180715
161Hyperparathyroidism (HP:0000843)1.58673025
162Generalized amyotrophy (HP:0003700)1.58055459
163Neurofibrillary tangles (HP:0002185)1.57495656
164Abnormality of the acetabulum (HP:0003170)1.57144116
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.56401209
166Abnormality of the thoracic spine (HP:0100711)1.54287164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.94978995
2PDK33.70556750
3PDK43.70556750
4PRPF4B3.22682442
5MAP3K103.12363313
6PKN23.07293133
7SMG12.93876032
8IRAK32.91443110
9TTN2.84339919
10LATS12.52557641
11PDK22.51448878
12ERN12.46009514
13TESK12.38041756
14EEF2K2.31539933
15ICK2.25715668
16PRKD32.15532195
17CDK122.14043049
18RIPK12.09893257
19SIK12.01822856
20PTK61.87571576
21STK31.66485098
22FGFR41.51034037
23MAP3K141.49381648
24MAP3K131.49368403
25NME21.47567612
26PDGFRA1.40545589
27TAOK21.34048741
28NEK21.29104667
29MST1R1.23782296
30STK101.21903765
31TAOK11.21668512
32MAP3K31.17715229
33DMPK1.15249230
34MTOR1.14853028
35WNK41.12641397
36MAP2K31.12141900
37STK381.11503482
38EPHB11.10832626
39CDC42BPA1.10485999
40CDK61.09517032
41BMX1.05166935
42CAMK1D1.04617037
43LRRK21.04197727
44CAMK1G1.03432310
45DYRK1B0.95937375
46ARAF0.94813553
47RIPK40.94474824
48PTK2B0.94456511
49NEK90.90780258
50EPHA20.87805729
51FRK0.86096348
52LMTK20.85429814
53PRKD20.85142218
54RPS6KA40.81291209
55SIK30.81062682
56DDR20.81038467
57MAP3K60.80953344
58PAK20.80935554
59PTK20.77907800
60JAK10.77665489
61LATS20.76806911
62MOS0.76256428
63TYK20.74372995
64NTRK10.73970729
65MAP3K70.73555757
66IRAK40.73024483
67PDGFRB0.71853578
68FGFR30.70946350
69PAK40.70101485
70TGFBR20.69174925
71NEK10.67759028
72STK38L0.67550448
73BCKDK0.67425013
74MAP4K10.67013690
75TESK20.65053850
76FER0.63824897
77TBK10.63817297
78RPS6KA20.63511058
79MAPKAPK30.62397988
80CDK40.62299509
81RET0.62270299
82MARK20.61986145
83PDK10.61870091
84PIM20.58373598
85MAP3K80.58234146
86EPHB20.57691064
87PRKAA10.57277505
88MAP3K50.57203590
89MAP3K110.57144983
90TRPM70.56763789
91JAK20.55899910
92MAP3K90.55589358
93EPHA30.54089703
94WNK10.54021104
95PRKAA20.53787927
96PDPK10.53590653
97TAOK30.53437693
98PRKG20.53431417
99SCYL20.53195127
100MELK0.53048775
101FLT30.52357240
102FGFR10.52129957
103MET0.51929081
104MAPK110.51116523
105TYRO30.48172903
106TTK0.46192504
107HIPK20.45437655
108MAP3K20.44219825
109PAK30.44050238
110CDK70.44026182
111MAPKAPK20.42779824
112FGR0.42683049
113ALK0.42592060
114KSR20.42549705
115RPS6KL10.42540559
116RPS6KC10.42540559
117BRD40.41753961
118JAK30.41593801
119STK240.41452155
120MYLK0.41204381
121CSK0.40811600
122MAP3K10.40231892
123BLK0.39950412
124GSK3A0.39757347
125ERBB40.39675112
126CLK10.39455839
127STK40.38410781
128ZAP700.38359168
129SGK30.36966935
130OBSCN0.36936582
131CDK90.36868904
132MATK0.36589532
133BRAF0.35577601
134PRKCH0.33138656
135MARK30.32949225
136PRKD10.32554389
137RPS6KA10.32487963
138RPS6KB20.32342750

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04556300
2Nitrogen metabolism_Homo sapiens_hsa009102.74468224
3Fatty acid degradation_Homo sapiens_hsa000712.52560298
4Other glycan degradation_Homo sapiens_hsa005112.40708568
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37493690
6Propanoate metabolism_Homo sapiens_hsa006402.24630081
7Arginine biosynthesis_Homo sapiens_hsa002202.17434245
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.16991065
9PPAR signaling pathway_Homo sapiens_hsa033202.16268266
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00026531
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.89008003
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88940682
13Pyruvate metabolism_Homo sapiens_hsa006201.86140505
14Fatty acid metabolism_Homo sapiens_hsa012121.85848161
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76133505
16Tryptophan metabolism_Homo sapiens_hsa003801.71071171
17Selenocompound metabolism_Homo sapiens_hsa004501.68625345
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62150336
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61647995
20Carbon metabolism_Homo sapiens_hsa012001.60374595
21Thyroid cancer_Homo sapiens_hsa052161.59000402
22Complement and coagulation cascades_Homo sapiens_hsa046101.58929739
23Fatty acid biosynthesis_Homo sapiens_hsa000611.58502937
24Fat digestion and absorption_Homo sapiens_hsa049751.56108686
25Lysine degradation_Homo sapiens_hsa003101.55745514
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53588589
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53095357
28Bile secretion_Homo sapiens_hsa049761.52923983
29Non-small cell lung cancer_Homo sapiens_hsa052231.49629031
30Caffeine metabolism_Homo sapiens_hsa002321.38202293
31Renal cell carcinoma_Homo sapiens_hsa052111.36424370
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31949375
33B cell receptor signaling pathway_Homo sapiens_hsa046621.31562286
34Hepatitis C_Homo sapiens_hsa051601.28696644
35TNF signaling pathway_Homo sapiens_hsa046681.28255165
36Insulin resistance_Homo sapiens_hsa049311.27685646
37Prion diseases_Homo sapiens_hsa050201.27617986
38Endometrial cancer_Homo sapiens_hsa052131.26494968
39Biosynthesis of amino acids_Homo sapiens_hsa012301.25822768
40Starch and sucrose metabolism_Homo sapiens_hsa005001.24857186
41Hepatitis B_Homo sapiens_hsa051611.22085263
42Shigellosis_Homo sapiens_hsa051311.21951354
43Lysosome_Homo sapiens_hsa041421.20005426
44Glucagon signaling pathway_Homo sapiens_hsa049221.19542544
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.17876972
46Influenza A_Homo sapiens_hsa051641.17658045
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16530327
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15924122
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14992971
50Apoptosis_Homo sapiens_hsa042101.14884503
51Glycerolipid metabolism_Homo sapiens_hsa005611.12942466
52Notch signaling pathway_Homo sapiens_hsa043301.11279318
53Prostate cancer_Homo sapiens_hsa052151.09552188
54Leishmaniasis_Homo sapiens_hsa051401.08913821
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.08163443
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.06431127
57Staphylococcus aureus infection_Homo sapiens_hsa051501.05944087
58Butanoate metabolism_Homo sapiens_hsa006501.03528011
59Adherens junction_Homo sapiens_hsa045201.02397005
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.00142834
61Malaria_Homo sapiens_hsa051440.99985453
62ABC transporters_Homo sapiens_hsa020100.98130239
63Glioma_Homo sapiens_hsa052140.97871264
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97078012
65Measles_Homo sapiens_hsa051620.96850175
66Chemical carcinogenesis_Homo sapiens_hsa052040.96806601
67Salmonella infection_Homo sapiens_hsa051320.96458855
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95116520
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94535339
70Prolactin signaling pathway_Homo sapiens_hsa049170.93672068
71Dorso-ventral axis formation_Homo sapiens_hsa043200.93163443
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91955660
73ErbB signaling pathway_Homo sapiens_hsa040120.91394855
74AMPK signaling pathway_Homo sapiens_hsa041520.91289898
75Tuberculosis_Homo sapiens_hsa051520.90493848
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90208392
77Small cell lung cancer_Homo sapiens_hsa052220.89118794
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88857671
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88674296
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85412860
81Pentose phosphate pathway_Homo sapiens_hsa000300.85328251
82Peroxisome_Homo sapiens_hsa041460.85128488
83Pertussis_Homo sapiens_hsa051330.84928775
84beta-Alanine metabolism_Homo sapiens_hsa004100.84851650
85Focal adhesion_Homo sapiens_hsa045100.84431370
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84425273
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83939511
88ECM-receptor interaction_Homo sapiens_hsa045120.83646465
89Viral carcinogenesis_Homo sapiens_hsa052030.82677933
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.82333013
91Phenylalanine metabolism_Homo sapiens_hsa003600.80255432
92mTOR signaling pathway_Homo sapiens_hsa041500.79499168
93Endocytosis_Homo sapiens_hsa041440.79033951
94Retinol metabolism_Homo sapiens_hsa008300.78823031
95GnRH signaling pathway_Homo sapiens_hsa049120.76156232
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76024996
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75950066
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75617158
99Proteoglycans in cancer_Homo sapiens_hsa052050.75374768
100Chronic myeloid leukemia_Homo sapiens_hsa052200.74267500
101Amoebiasis_Homo sapiens_hsa051460.73659081
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73176489
103Legionellosis_Homo sapiens_hsa051340.72331255
104HTLV-I infection_Homo sapiens_hsa051660.71628322
105Toxoplasmosis_Homo sapiens_hsa051450.71457132
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.71208836
107Herpes simplex infection_Homo sapiens_hsa051680.70722055
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68875880
109T cell receptor signaling pathway_Homo sapiens_hsa046600.67566644
110Vibrio cholerae infection_Homo sapiens_hsa051100.66989979
111Colorectal cancer_Homo sapiens_hsa052100.66309535
112Inositol phosphate metabolism_Homo sapiens_hsa005620.65955884
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65189775
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65007285
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.64446582
116Insulin signaling pathway_Homo sapiens_hsa049100.64167534
117Sphingolipid metabolism_Homo sapiens_hsa006000.64015996
118Bladder cancer_Homo sapiens_hsa052190.63679168
119Phagosome_Homo sapiens_hsa041450.63088155
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.62788828
121Protein digestion and absorption_Homo sapiens_hsa049740.61359252
122Histidine metabolism_Homo sapiens_hsa003400.61151339
123Pathways in cancer_Homo sapiens_hsa052000.60932601
124Estrogen signaling pathway_Homo sapiens_hsa049150.59889874
125Dilated cardiomyopathy_Homo sapiens_hsa054140.59654334
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.59060165
127Choline metabolism in cancer_Homo sapiens_hsa052310.58595957
128N-Glycan biosynthesis_Homo sapiens_hsa005100.58335349
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58276310
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58227631
131Fructose and mannose metabolism_Homo sapiens_hsa000510.57686192
132Vitamin B6 metabolism_Homo sapiens_hsa007500.56595165
133FoxO signaling pathway_Homo sapiens_hsa040680.55085979
134Chemokine signaling pathway_Homo sapiens_hsa040620.54967722
135Viral myocarditis_Homo sapiens_hsa054160.54870967
136Platelet activation_Homo sapiens_hsa046110.53757913
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53269428
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52759223
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.51371321
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50789097
141Vitamin digestion and absorption_Homo sapiens_hsa049770.49733721
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.48721343
143Pancreatic cancer_Homo sapiens_hsa052120.48693557
144HIF-1 signaling pathway_Homo sapiens_hsa040660.48688452
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48045410
146VEGF signaling pathway_Homo sapiens_hsa043700.47514982
147Renin-angiotensin system_Homo sapiens_hsa046140.46435941
148Mineral absorption_Homo sapiens_hsa049780.44241481
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.43788215
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43668790
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.43397067
152Galactose metabolism_Homo sapiens_hsa000520.42859640
153Acute myeloid leukemia_Homo sapiens_hsa052210.42672610
154Type II diabetes mellitus_Homo sapiens_hsa049300.41699258
155MicroRNAs in cancer_Homo sapiens_hsa052060.41083856
156Tyrosine metabolism_Homo sapiens_hsa003500.40260433
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40059529
158Osteoclast differentiation_Homo sapiens_hsa043800.35996462
159Glutathione metabolism_Homo sapiens_hsa004800.34459436
160Tight junction_Homo sapiens_hsa045300.34306594
161Sulfur metabolism_Homo sapiens_hsa009200.33049041

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