ZDHHC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75136199
2L-phenylalanine metabolic process (GO:0006558)4.75136199
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.73343958
4L-phenylalanine catabolic process (GO:0006559)4.73343958
5glycine metabolic process (GO:0006544)4.59684618
6cysteine metabolic process (GO:0006534)4.51284935
7serine family amino acid biosynthetic process (GO:0009070)4.50548933
8aromatic amino acid family catabolic process (GO:0009074)4.40315591
9glyoxylate metabolic process (GO:0046487)4.29819895
10lysine metabolic process (GO:0006553)4.18174143
11lysine catabolic process (GO:0006554)4.18174143
12positive regulation of immune response to tumor cell (GO:0002839)4.15489150
13regulation of immune response to tumor cell (GO:0002837)4.15489150
14regulation of response to tumor cell (GO:0002834)4.15489150
15positive regulation of response to tumor cell (GO:0002836)4.15489150
16indole-containing compound catabolic process (GO:0042436)4.10268072
17indolalkylamine catabolic process (GO:0046218)4.10268072
18tryptophan catabolic process (GO:0006569)4.10268072
19kynurenine metabolic process (GO:0070189)4.09403770
20serine family amino acid metabolic process (GO:0009069)4.07762618
21folic acid-containing compound biosynthetic process (GO:0009396)4.01898738
22DNA double-strand break processing (GO:0000729)4.00254380
23urea cycle (GO:0000050)3.98687527
24urea metabolic process (GO:0019627)3.98687527
25bile acid biosynthetic process (GO:0006699)3.98315379
26serine family amino acid catabolic process (GO:0009071)3.96216449
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94740546
28tryptophan metabolic process (GO:0006568)3.93792881
29alpha-linolenic acid metabolic process (GO:0036109)3.87972563
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.87964613
31homocysteine metabolic process (GO:0050667)3.82210178
32mitotic sister chromatid cohesion (GO:0007064)3.80040299
33L-serine metabolic process (GO:0006563)3.76237423
34ribosome assembly (GO:0042255)3.74656428
35proteasome assembly (GO:0043248)3.74336613
36sulfur amino acid catabolic process (GO:0000098)3.73686017
37negative regulation of fibrinolysis (GO:0051918)3.71972068
38folic acid metabolic process (GO:0046655)3.71481156
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70069637
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68067650
41replication fork processing (GO:0031297)3.62917659
42transcription from mitochondrial promoter (GO:0006390)3.62647631
43GMP metabolic process (GO:0046037)3.62634661
44one-carbon metabolic process (GO:0006730)3.62032144
45double-strand break repair via nonhomologous end joining (GO:0006303)3.61541892
46non-recombinational repair (GO:0000726)3.61541892
47protein carboxylation (GO:0018214)3.60316622
48peptidyl-glutamic acid carboxylation (GO:0017187)3.60316622
49nitrogen cycle metabolic process (GO:0071941)3.59216998
50tetrahydrofolate metabolic process (GO:0046653)3.57984088
51negative regulation of ligase activity (GO:0051352)3.57369649
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57369649
53complement activation, alternative pathway (GO:0006957)3.55327831
54regulation of protein activation cascade (GO:2000257)3.52809163
55imidazole-containing compound metabolic process (GO:0052803)3.51205716
56DNA catabolic process, exonucleolytic (GO:0000738)3.50000306
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49105035
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47117051
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47117051
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47117051
61purine nucleotide salvage (GO:0032261)3.45430435
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44409500
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44409500
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44013789
65amino-acid betaine metabolic process (GO:0006577)3.43520567
66high-density lipoprotein particle remodeling (GO:0034375)3.43469562
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.41796663
68regulation of cellular amino acid metabolic process (GO:0006521)3.40939006
69regulation of fibrinolysis (GO:0051917)3.34654502
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33403119
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.33403119
72alpha-amino acid catabolic process (GO:1901606)3.31940997
73regulation of complement activation (GO:0030449)3.31728607
74aromatic amino acid family metabolic process (GO:0009072)3.30278655
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.27290204
76mitochondrial DNA replication (GO:0006264)3.27170804
77mitotic recombination (GO:0006312)3.26748235
78telomere maintenance via recombination (GO:0000722)3.24545597
79aldehyde catabolic process (GO:0046185)3.21571274
80bile acid metabolic process (GO:0008206)3.20529964
81protein deneddylation (GO:0000338)3.19987756
82folic acid-containing compound metabolic process (GO:0006760)3.19300067
83regulation of triglyceride catabolic process (GO:0010896)3.15295814
84valine metabolic process (GO:0006573)3.14342259
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10571528
86cullin deneddylation (GO:0010388)3.10337317
872-oxoglutarate metabolic process (GO:0006103)3.09586265
88tyrosine metabolic process (GO:0006570)3.07824081
89disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.05965260
90killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.05965260
91pteridine-containing compound biosynthetic process (GO:0042559)3.05812191
92protein-lipid complex remodeling (GO:0034368)3.04148835
93macromolecular complex remodeling (GO:0034367)3.04148835
94plasma lipoprotein particle remodeling (GO:0034369)3.04148835
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02554247
96cellular amino acid catabolic process (GO:0009063)3.02067400
97negative regulation of cholesterol transport (GO:0032375)3.00810412
98negative regulation of sterol transport (GO:0032372)3.00810412
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99698976
100nucleobase biosynthetic process (GO:0046112)2.98219566
101establishment of integrated proviral latency (GO:0075713)2.98135637
102reverse cholesterol transport (GO:0043691)2.97202279
103positive regulation of cell cycle arrest (GO:0071158)2.96207541
104purine nucleobase biosynthetic process (GO:0009113)2.93981878
105DNA unwinding involved in DNA replication (GO:0006268)2.93938664
106DNA strand elongation involved in DNA replication (GO:0006271)2.92258518
107cytochrome complex assembly (GO:0017004)2.91350805
108positive regulation of ligase activity (GO:0051351)2.90844812
109respiratory chain complex IV assembly (GO:0008535)2.90350948
110sulfur amino acid biosynthetic process (GO:0000097)2.90125462
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87292332
112cellular modified amino acid catabolic process (GO:0042219)2.87174487
113ethanol oxidation (GO:0006069)2.86073307
114mitochondrial RNA metabolic process (GO:0000959)2.85788085
115IMP biosynthetic process (GO:0006188)2.84262955
116pteridine-containing compound metabolic process (GO:0042558)2.83120760
117sulfur amino acid metabolic process (GO:0000096)2.82467155
118aspartate family amino acid catabolic process (GO:0009068)2.82287869
119indolalkylamine metabolic process (GO:0006586)2.82237732
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.81749585
121pseudouridine synthesis (GO:0001522)2.81646768
122L-alpha-amino acid transmembrane transport (GO:1902475)2.80524970
123chromatin remodeling at centromere (GO:0031055)2.80351555
124triglyceride homeostasis (GO:0070328)2.79273992
125acylglycerol homeostasis (GO:0055090)2.79273992
126oxaloacetate metabolic process (GO:0006107)2.78476462
127DNA strand elongation (GO:0022616)2.76167388
128benzene-containing compound metabolic process (GO:0042537)2.76164963
129urate metabolic process (GO:0046415)2.75451983
130aspartate family amino acid metabolic process (GO:0009066)2.75099738
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74908225
132isotype switching (GO:0045190)2.74908225
133somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74908225
134nucleoside salvage (GO:0043174)2.74749814
135establishment of viral latency (GO:0019043)2.74181369
136bile acid and bile salt transport (GO:0015721)2.73524391
137cellular biogenic amine catabolic process (GO:0042402)2.73450580
138amine catabolic process (GO:0009310)2.73450580
139negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.73410260
140regulation of cholesterol esterification (GO:0010872)2.72509961
141IMP metabolic process (GO:0046040)2.71205477
142cellular glucuronidation (GO:0052695)2.70984509
143blood coagulation, intrinsic pathway (GO:0007597)2.70905530
144drug transport (GO:0015893)2.70082160
145CENP-A containing nucleosome assembly (GO:0034080)2.69298647
146drug transmembrane transport (GO:0006855)2.68863673
147plasma lipoprotein particle clearance (GO:0034381)2.68771246
148cellular ketone body metabolic process (GO:0046950)2.68641102
149purine-containing compound salvage (GO:0043101)2.68395270
150telomere maintenance via semi-conservative replication (GO:0032201)2.68249871
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.67198848
152DNA replication checkpoint (GO:0000076)2.67182904
153pyridine nucleotide biosynthetic process (GO:0019363)2.66461928
154nicotinamide nucleotide biosynthetic process (GO:0019359)2.66461928
155AMP metabolic process (GO:0046033)2.66165580
156positive regulation of macrophage differentiation (GO:0045651)2.66045598
157carnitine metabolic process (GO:0009437)2.65248931
158response to X-ray (GO:0010165)2.65091185
159regulation of translation in response to stress (GO:0043555)2.65050657
160coenzyme catabolic process (GO:0009109)2.64375736
161pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.63252535
162DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.63204491
163DNA replication initiation (GO:0006270)2.63033753
164negative regulation of protein ubiquitination (GO:0031397)2.61595928
165regulation of double-strand break repair via homologous recombination (GO:0010569)2.60463629
166regulation of ligase activity (GO:0051340)2.58892478
167regulation of DNA endoreduplication (GO:0032875)2.58010369
168G1/S transition of mitotic cell cycle (GO:0000082)2.57877810
169cell cycle G1/S phase transition (GO:0044843)2.57877810
170DNA-dependent DNA replication (GO:0006261)2.54724282
171regulation of translational termination (GO:0006449)2.54398641
172regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54254279
173DNA ligation (GO:0006266)2.52887417
174regulation of cellular amine metabolic process (GO:0033238)2.52232998
175activated T cell proliferation (GO:0050798)2.51467791
176antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49481603
177formation of translation preinitiation complex (GO:0001731)2.49175745
178negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.47501520
179rRNA modification (GO:0000154)2.47142321
180negative regulation of cell cycle G1/S phase transition (GO:1902807)2.46846417
181negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.46846417
182positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44059067
183tRNA aminoacylation for protein translation (GO:0006418)2.43991969
184protein neddylation (GO:0045116)2.43442326
185positive regulation of protein ubiquitination (GO:0031398)2.42873824
186nucleotide-excision repair, DNA gap filling (GO:0006297)2.41497105
187amino acid activation (GO:0043038)2.40789973
188tRNA aminoacylation (GO:0043039)2.40789973
189mitotic sister chromatid segregation (GO:0000070)2.40286598
190negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.38031092
191histone exchange (GO:0043486)2.38018258
192necroptotic process (GO:0070266)2.37058538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33922407
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60028602
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.62609179
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54046164
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.38177461
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.31511566
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.23687214
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.06374377
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80349251
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.76175637
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69571973
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50447875
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.43338901
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36166864
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32413950
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31344003
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.28321693
18* GABP_17652178_ChIP-ChIP_JURKAT_Human2.27731016
19AR_21909140_ChIP-Seq_LNCAP_Human2.23090780
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22874067
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16277426
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09471464
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.08503912
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.06212875
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04853616
26* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98299746
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98013796
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93040213
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82626032
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80665007
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77170027
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76322663
33DCP1A_22483619_ChIP-Seq_HELA_Human1.74935050
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72340564
35VDR_23849224_ChIP-Seq_CD4+_Human1.71062352
36* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66777368
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66357828
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.65309891
39XRN2_22483619_ChIP-Seq_HELA_Human1.63780586
40* IRF8_21731497_ChIP-ChIP_J774_Mouse1.62925861
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.62504627
42* GABP_19822575_ChIP-Seq_HepG2_Human1.57619741
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53185147
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52914094
45GATA1_22025678_ChIP-Seq_K562_Human1.52743338
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.51289856
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48321536
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46116914
49MYB_26560356_Chip-Seq_TH2_Human1.46115496
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45635091
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.45183018
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45168230
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44354483
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42483901
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42234744
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41992409
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39896977
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.38308512
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37447495
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36047737
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.31879603
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31393265
63* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26543634
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25451333
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23694740
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22477646
67MYC_22102868_ChIP-Seq_BL_Human1.18581746
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17490591
69* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15893612
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.14518289
71ELK1_19687146_ChIP-ChIP_HELA_Human1.14498412
72KDM5A_27292631_Chip-Seq_BREAST_Human1.14361464
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12439197
74TTF2_22483619_ChIP-Seq_HELA_Human1.12229132
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11543151
76CIITA_25753668_ChIP-Seq_RAJI_Human1.11471467
77MYB_26560356_Chip-Seq_TH1_Human1.11266331
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10780410
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09942430
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09894024
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09868621
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07907883
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07705262
84CLOCK_20551151_ChIP-Seq_293T_Human1.07294930
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07163886
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.06409941
87GATA3_26560356_Chip-Seq_TH2_Human1.03977007
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01649709
89TFEB_21752829_ChIP-Seq_HELA_Human1.01385190
90* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00441105
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99495339
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99411291
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99175712
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.97644145
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96482072
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96066270
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95101509
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94124638
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93904154
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93813429
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93180250
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92293707
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92074290
104ELF5_23300383_ChIP-Seq_T47D_Human0.91719654
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91241209
106BP1_19119308_ChIP-ChIP_Hs578T_Human0.90599012
107SPI1_23547873_ChIP-Seq_NB4_Human0.90107585
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89756296
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.87679874
110MYC_18940864_ChIP-ChIP_HL60_Human0.87490305
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87433233
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.87341675
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87204595
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86773990
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86208875
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85520600
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83861024
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83281817
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82738281
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82121909
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81905357
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81630284
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81355485
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80793692
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.80741729
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80578137
127SALL4_22934838_ChIP-ChIP_CD34+_Human0.79001938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.51879525
2MP0005360_urolithiasis5.45187686
3MP0003183_abnormal_peptide_metabolism4.80782121
4MP0005085_abnormal_gallbladder_physiolo4.59895324
5MP0005365_abnormal_bile_salt4.53876658
6MP0003806_abnormal_nucleotide_metabolis4.29274283
7MP0008875_abnormal_xenobiotic_pharmacok3.46614328
8MP0005670_abnormal_white_adipose3.04577732
9MP0003252_abnormal_bile_duct2.72603195
10MP0005083_abnormal_biliary_tract2.63888836
11MP0009840_abnormal_foam_cell2.43612925
12MP0010329_abnormal_lipoprotein_level2.36042527
13MP0005332_abnormal_amino_acid2.28268665
14MP0001666_abnormal_nutrient_absorption2.24921269
15MP0002148_abnormal_hypersensitivity_rea2.15134662
16MP0002138_abnormal_hepatobiliary_system2.12162821
17MP0005387_immune_system_phenotype1.97666996
18MP0001790_abnormal_immune_system1.97666996
19MP0003693_abnormal_embryo_hatching1.96333126
20MP0003186_abnormal_redox_activity1.96329256
21MP0009697_abnormal_copulation1.93198281
22MP0003763_abnormal_thymus_physiology1.92364369
23MP0006082_CNS_inflammation1.90276855
24MP0002163_abnormal_gland_morphology1.89738177
25MP0003786_premature_aging1.84681111
26MP0001764_abnormal_homeostasis1.82249506
27MP0003656_abnormal_erythrocyte_physiolo1.81432042
28MP0000609_abnormal_liver_physiology1.78054004
29MP0010094_abnormal_chromosome_stability1.77963335
30MP0002006_tumorigenesis1.75957519
31MP0002166_altered_tumor_susceptibility1.75793163
32MP0005671_abnormal_response_to1.72545214
33MP0005319_abnormal_enzyme/_coenzyme1.66341902
34MP0004957_abnormal_blastocyst_morpholog1.64409409
35MP0003195_calcinosis1.62472189
36MP0003191_abnormal_cellular_cholesterol1.61968558
37MP0005000_abnormal_immune_tolerance1.51827993
38MP0002396_abnormal_hematopoietic_system1.49824041
39MP0002452_abnormal_antigen_presenting1.49114721
40MP0002420_abnormal_adaptive_immunity1.47018887
41MP0001819_abnormal_immune_cell1.46752994
42MP0003868_abnormal_feces_composition1.46598251
43MP0002723_abnormal_immune_serum1.45219403
44MP0003111_abnormal_nucleus_morphology1.45165382
45MP0004019_abnormal_vitamin_homeostasis1.43645135
46MP0003077_abnormal_cell_cycle1.41684060
47MP0008961_abnormal_basal_metabolism1.34864717
48MP0006054_spinal_hemorrhage1.34535079
49MP0000598_abnormal_liver_morphology1.33180944
50MP0008260_abnormal_autophagy1.26347607
51MP0003705_abnormal_hypodermis_morpholog1.25060571
52MP0005584_abnormal_enzyme/coenzyme_acti1.24318817
53MP0006036_abnormal_mitochondrial_physio1.23837023
54MP0002118_abnormal_lipid_homeostasis1.23504668
55MP0009643_abnormal_urine_homeostasis1.23070955
56MP0000703_abnormal_thymus_morphology1.23060552
57MP0000716_abnormal_immune_system1.22128452
58MP0008469_abnormal_protein_level1.11626699
59MP0008057_abnormal_DNA_replication1.11122952
60MP0009763_increased_sensitivity_to1.10321121
61MP0004147_increased_porphyrin_level1.08497604
62MP0005075_abnormal_melanosome_morpholog1.07655638
63MP0001835_abnormal_antigen_presentation1.06891323
64MP0008058_abnormal_DNA_repair1.06841537
65MP0003436_decreased_susceptibility_to1.05824086
66MP0001853_heart_inflammation1.03554944
67MP0005379_endocrine/exocrine_gland_phen1.03524423
68MP0003448_altered_tumor_morphology1.02540556
69MP0005220_abnormal_exocrine_pancreas1.01644733
70MP0003303_peritoneal_inflammation1.01237768
71MP0003011_delayed_dark_adaptation1.00768932
72MP0009785_altered_susceptibility_to1.00508642
73MP0001191_abnormal_skin_condition0.97393009
74MP0005408_hypopigmentation0.97370950
75MP0006072_abnormal_retinal_apoptosis0.97057399
76MP0000465_gastrointestinal_hemorrhage0.96733120
77MP0005636_abnormal_mineral_homeostasis0.95902779
78MP0002405_respiratory_system_inflammati0.95090182
79MP0000685_abnormal_immune_system0.93874395
80MP0009333_abnormal_splenocyte_physiolog0.91995905
81MP0005451_abnormal_body_composition0.91782546
82MP0001851_eye_inflammation0.90930798
83MP0008007_abnormal_cellular_replicative0.90419934
84MP0002102_abnormal_ear_morphology0.89734390
85MP0000490_abnormal_crypts_of0.89420194
86MP0000313_abnormal_cell_death0.87346016
87MP0003866_abnormal_defecation0.87327782
88MP0010352_gastrointestinal_tract_polyps0.86690109
89MP0005084_abnormal_gallbladder_morpholo0.86149216
90MP0009764_decreased_sensitivity_to0.84908473
91MP0003718_maternal_effect0.84871789
92MP0001730_embryonic_growth_arrest0.84245907
93MP0005464_abnormal_platelet_physiology0.84034604
94MP0001545_abnormal_hematopoietic_system0.83981396
95MP0005397_hematopoietic_system_phenotyp0.83981396
96MP0003724_increased_susceptibility_to0.83499762
97MP0003221_abnormal_cardiomyocyte_apopto0.80345457
98MP0009765_abnormal_xenobiotic_induced0.80090573
99MP0005376_homeostasis/metabolism_phenot0.78980809
100MP0001845_abnormal_inflammatory_respons0.78504347
101MP0008932_abnormal_embryonic_tissue0.78292114
102MP0002019_abnormal_tumor_incidence0.77352343
103MP0006035_abnormal_mitochondrial_morpho0.76080553
104MP0000689_abnormal_spleen_morphology0.75489608
105MP0005058_abnormal_lysosome_morphology0.74757522
106MP0005164_abnormal_response_to0.74422341
107MP0005025_abnormal_response_to0.74376475
108MP0002970_abnormal_white_adipose0.74345604
109MP0005266_abnormal_metabolism0.73901295
110MP0004808_abnormal_hematopoietic_stem0.72931067
111MP0002132_abnormal_respiratory_system0.72162171
112MP0004947_skin_inflammation0.72112653
113MP0001533_abnormal_skeleton_physiology0.70245473
114MP0009642_abnormal_blood_homeostasis0.70220391
115MP0002277_abnormal_respiratory_mucosa0.69951321
116MP0005647_abnormal_sex_gland0.69705725
117MP0010307_abnormal_tumor_latency0.69296049
118MP0002722_abnormal_immune_system0.67853963
119MP0001881_abnormal_mammary_gland0.67836981
120MP0001915_intracranial_hemorrhage0.67252866
121MP0005023_abnormal_wound_healing0.67073493
122MP0010155_abnormal_intestine_physiology0.63344423
123MP0002419_abnormal_innate_immunity0.62322424
124MP0001800_abnormal_humoral_immune0.62084115
125MP0009053_abnormal_anal_canal0.60497240
126MP0001243_abnormal_dermal_layer0.60190665
127MP0002429_abnormal_blood_cell0.60079155
128MP0002398_abnormal_bone_marrow0.59990348
129MP0000350_abnormal_cell_proliferation0.59757404
130MP0002136_abnormal_kidney_physiology0.59400165
131MP0004782_abnormal_surfactant_physiolog0.59078100
132MP0000604_amyloidosis0.58951823
133MP0000858_altered_metastatic_potential0.58864201
134MP0000358_abnormal_cell_content/0.58346391
135MP0001873_stomach_inflammation0.57234739
136MP0009672_abnormal_birth_weight0.56138526
137MP0003984_embryonic_growth_retardation0.55357327
138MP0008873_increased_physiological_sensi0.55031504
139MP0002080_prenatal_lethality0.54788427
140MP0002088_abnormal_embryonic_growth/wei0.53614856
141MP0001756_abnormal_urination0.53092122

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.62913086
2Hypobetalipoproteinemia (HP:0003563)5.52617939
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.52592723
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.14572726
5Deep venous thrombosis (HP:0002625)4.82010821
6Abnormality of pyrimidine metabolism (HP:0004353)4.43812457
7Prolonged partial thromboplastin time (HP:0003645)4.28617377
8Xanthomatosis (HP:0000991)4.11958054
9Hyperammonemia (HP:0001987)4.01201265
10Volvulus (HP:0002580)4.01137428
11Hypolipoproteinemia (HP:0010981)3.80181049
12Papilledema (HP:0001085)3.72312089
13Abnormality of methionine metabolism (HP:0010901)3.71373003
14Abnormality of sulfur amino acid metabolism (HP:0004339)3.68396953
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.58381375
16Complement deficiency (HP:0004431)3.45543418
17Hyperlipoproteinemia (HP:0010980)3.43526993
18Hyperglycinemia (HP:0002154)3.41796470
19Stomatitis (HP:0010280)3.39043339
20Abnormality of the common coagulation pathway (HP:0010990)3.36818003
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.34253621
22Fat malabsorption (HP:0002630)3.30903762
23Oligodactyly (hands) (HP:0001180)3.26111572
24Abnormality of the intrinsic pathway (HP:0010989)3.25706903
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23988340
26Joint hemorrhage (HP:0005261)3.16023584
27Ketosis (HP:0001946)3.15789287
28Abnormality of glycine metabolism (HP:0010895)3.13680336
29Abnormality of serine family amino acid metabolism (HP:0010894)3.13680336
30Abnormality of fatty-acid metabolism (HP:0004359)3.12422326
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10522800
32Panhypogammaglobulinemia (HP:0003139)3.09046605
33Mediastinal lymphadenopathy (HP:0100721)3.05133650
34Hypoglycemic coma (HP:0001325)3.04680172
35Acute hepatic failure (HP:0006554)3.04674884
36Autoimmune hemolytic anemia (HP:0001890)3.04272124
37Hyperbilirubinemia (HP:0002904)3.02891406
38Hyperglycinuria (HP:0003108)3.02296365
39Abnormality of serum amino acid levels (HP:0003112)3.01239374
40Elevated erythrocyte sedimentation rate (HP:0003565)2.96174859
41Abnormality of nucleobase metabolism (HP:0010932)2.94081829
42Stenosis of the external auditory canal (HP:0000402)2.93856849
43Hepatocellular carcinoma (HP:0001402)2.91849178
44Steatorrhea (HP:0002570)2.86816889
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.86567636
46Chromsome breakage (HP:0040012)2.82776803
47Hypoalphalipoproteinemia (HP:0003233)2.81757624
48Abnormality of complement system (HP:0005339)2.81493584
49Rough bone trabeculation (HP:0100670)2.78251981
50Spastic diplegia (HP:0001264)2.75045400
51Dicarboxylic aciduria (HP:0003215)2.72224536
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72224536
53Delayed CNS myelination (HP:0002188)2.71745521
54Testicular atrophy (HP:0000029)2.60700566
55Recurrent viral infections (HP:0004429)2.60496602
56Epidermoid cyst (HP:0200040)2.60054527
57Encephalitis (HP:0002383)2.55464008
58Abnormality of chromosome stability (HP:0003220)2.54545263
59Posterior subcapsular cataract (HP:0007787)2.52997967
60Myelodysplasia (HP:0002863)2.51774120
61Hypoproteinemia (HP:0003075)2.49640011
62Abnormality of the anterior horn cell (HP:0006802)2.49387319
63Degeneration of anterior horn cells (HP:0002398)2.49387319
64Choroideremia (HP:0001139)2.47499718
65Lethargy (HP:0001254)2.47276735
66Generalized aminoaciduria (HP:0002909)2.46497532
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45416637
68Reduced antithrombin III activity (HP:0001976)2.44832072
69IgM deficiency (HP:0002850)2.44175307
70IgG deficiency (HP:0004315)2.43169992
71Nausea (HP:0002018)2.40832669
72Abnormality of small intestinal villus morphology (HP:0011472)2.40753899
73Villous atrophy (HP:0011473)2.40753899
74Abnormality of the preputium (HP:0100587)2.39606983
75Oral leukoplakia (HP:0002745)2.37839432
76Hypercholesterolemia (HP:0003124)2.37672851
77Duodenal stenosis (HP:0100867)2.37138033
78Small intestinal stenosis (HP:0012848)2.37138033
79Cerebral edema (HP:0002181)2.36416574
80Metabolic acidosis (HP:0001942)2.31557128
81Oligodactyly (HP:0012165)2.29526874
82B lymphocytopenia (HP:0010976)2.28966386
83Increased hepatocellular lipid droplets (HP:0006565)2.28929517
84Optic neuritis (HP:0100653)2.28694235
85Retrobulbar optic neuritis (HP:0100654)2.28694235
86Megaloblastic anemia (HP:0001889)2.28289254
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.27808887
88Myositis (HP:0100614)2.27132329
89Exertional dyspnea (HP:0002875)2.26607481
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.26314745
91Acanthocytosis (HP:0001927)2.25413283
92Abnormality of T cells (HP:0002843)2.23908621
93T lymphocytopenia (HP:0005403)2.23880541
94Diastasis recti (HP:0001540)2.22352680
95Abnormality of iron homeostasis (HP:0011031)2.22345205
96Orchitis (HP:0100796)2.22314512
97Abnormality of T cell physiology (HP:0011840)2.19963474
98Abnormality of purine metabolism (HP:0004352)2.19216515
99Gout (HP:0001997)2.18377617
100Opisthotonus (HP:0002179)2.18346902
101Abnormality of transition element cation homeostasis (HP:0011030)2.17422657
102Meckel diverticulum (HP:0002245)2.16999747
103Chronic mucocutaneous candidiasis (HP:0002728)2.16682606
104Recurrent cutaneous fungal infections (HP:0011370)2.16682606
105Pancytopenia (HP:0001876)2.14444055
106Abnormality of T cell number (HP:0011839)2.13389442
107Abnormal gallbladder physiology (HP:0012438)2.13230897
108Cholecystitis (HP:0001082)2.13230897
109Abnormality of glycolysis (HP:0004366)2.12073209
110Increased serum pyruvate (HP:0003542)2.12073209
111Conjugated hyperbilirubinemia (HP:0002908)2.12006108
112Blepharitis (HP:0000498)2.11107119
113Abnormal trabecular bone morphology (HP:0100671)2.10671994
114Combined immunodeficiency (HP:0005387)2.08985759
115Thrombophlebitis (HP:0004418)2.08053583
116Abnormality of the ileum (HP:0001549)2.07756100
117Abnormality of the heme biosynthetic pathway (HP:0010472)2.07461454
118Abnormality of B cell number (HP:0010975)2.06539855
119Severe combined immunodeficiency (HP:0004430)2.06404749
120Poikilocytosis (HP:0004447)2.05974088
121Ketoacidosis (HP:0001993)2.05734733
122Recurrent gram-negative bacterial infections (HP:0005420)2.05145887
123Hepatic necrosis (HP:0002605)2.04961599
124Renal Fanconi syndrome (HP:0001994)2.04656786
125Increased serum ferritin (HP:0003281)2.03759850
126Lipid accumulation in hepatocytes (HP:0006561)2.02137556
127Thrombocytosis (HP:0001894)2.00650695
128Cholelithiasis (HP:0001081)1.98707373
129Microvesicular hepatic steatosis (HP:0001414)1.97335785
130Proximal tubulopathy (HP:0000114)1.97101133
131Elevated hepatic transaminases (HP:0002910)1.96173787
132Abnormal cartilage morphology (HP:0002763)1.93744011
133Neurodegeneration (HP:0002180)1.92504761
134Hepatocellular necrosis (HP:0001404)1.90879061
135Mitochondrial inheritance (HP:0001427)1.89840583
136Esophageal varix (HP:0002040)1.89823846
137Abnormal gallbladder morphology (HP:0012437)1.89276420
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89175068
139Myocardial infarction (HP:0001658)1.88760840
140Increased CSF lactate (HP:0002490)1.88688063
141Keratoconjunctivitis sicca (HP:0001097)1.87501539
142Neoplasm of the adrenal gland (HP:0100631)1.87322642
143Aplastic anemia (HP:0001915)1.86494477
144Vomiting (HP:0002013)1.86265144
145Pancreatitis (HP:0001733)1.85846856
146Ureteral duplication (HP:0000073)1.85574627
147Abnormality of the duodenum (HP:0002246)1.84713489
148Pulmonary infiltrates (HP:0002113)1.84561193
149Recurrent bacterial skin infections (HP:0005406)1.84460138
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.84253525
151Rhabdomyolysis (HP:0003201)1.83783108
152Spastic paraparesis (HP:0002313)1.83261674
153Increased serum lactate (HP:0002151)1.81999103
154Reticulocytopenia (HP:0001896)1.81981261
155Lactic acidosis (HP:0003128)1.80085169
156Hepatosplenomegaly (HP:0001433)1.79024561
157Brushfield spots (HP:0001088)1.78799834
158Glycosuria (HP:0003076)1.78035587
159Abnormality of urine glucose concentration (HP:0011016)1.78035587
160Neutropenia (HP:0001875)1.78008093
161Abnormal pupillary function (HP:0007686)1.77745864
162Increased intramyocellular lipid droplets (HP:0012240)1.77739387
163Methylmalonic aciduria (HP:0012120)1.77069739
164Clubbing of toes (HP:0100760)1.76956830
165Keratoconjunctivitis (HP:0001096)1.76940902
166Vascular calcification (HP:0004934)1.76567991
167Acute necrotizing encephalopathy (HP:0006965)1.76505766
168Neonatal onset (HP:0003623)1.75447530
169Increased muscle lipid content (HP:0009058)1.75138933
170Renal cortical cysts (HP:0000803)1.75123993
171Abnormality of reticulocytes (HP:0004312)1.75004089
172Spontaneous abortion (HP:0005268)1.74710514
173Multiple enchondromatosis (HP:0005701)1.74493301
174Bone marrow hypocellularity (HP:0005528)1.74027354
175Lymphoma (HP:0002665)1.73916952
176Systemic lupus erythematosus (HP:0002725)1.73462124
177Recurrent skin infections (HP:0001581)1.73408653
178Thyroiditis (HP:0100646)1.73352053
179Cerebral hypomyelination (HP:0006808)1.72756821
180Postnatal microcephaly (HP:0005484)1.71987566
181Gingival bleeding (HP:0000225)1.71207186
182Reticulocytosis (HP:0001923)1.71079429
183Recurrent abscess formation (HP:0002722)1.70643386
184Malnutrition (HP:0004395)1.70252918
185Late onset (HP:0003584)1.68881376
186Constricted visual fields (HP:0001133)1.68757765
187Palpitations (HP:0001962)1.68683214
188Amaurosis fugax (HP:0100576)1.68588979
189Abnormal mitochondria in muscle tissue (HP:0008316)1.68220818
190Abnormal enzyme/coenzyme activity (HP:0012379)1.66574934
191Birth length less than 3rd percentile (HP:0003561)1.63305722
192Abnormal platelet function (HP:0011869)1.62928073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.39324766
2EIF2AK13.13057781
3MST42.86181407
4WEE12.81160294
5BUB12.80126396
6CDC72.67514220
7NEK12.52954359
8ACVR1B2.51861684
9BMPR22.48852172
10FLT32.45642631
11STK162.22162490
12PKN22.19170083
13ERN12.16867718
14NME22.14797429
15TRIM282.13283431
16EIF2AK32.10314155
17NEK21.92011580
18NUAK11.83268165
19RPS6KA41.78494337
20VRK21.74277558
21SIK31.69608148
22BRSK21.67692648
23KDR1.65039479
24ERBB31.60110798
25NEK91.59428272
26PIK3CG1.54096436
27PBK1.52042215
28TYK21.51481391
29TSSK61.49967491
30TGFBR11.47306100
31STK391.45559151
32MAP2K31.43797063
33TESK21.43356113
34BCR1.41888139
35STK101.40811281
36VRK11.32801037
37TTK1.32506810
38PDK21.32301077
39SRPK11.30794989
40MAP4K11.29702880
41FGFR41.28593266
42ERBB41.23930255
43LRRK21.23002179
44ZAP701.21497566
45MAP3K121.20857470
46TBK11.19900677
47TXK1.19294254
48CDK41.17081579
49MKNK21.16624812
50DYRK31.16289072
51FRK1.15625155
52STK31.13855179
53AURKB1.09976369
54SCYL21.09686408
55MAP3K81.08714180
56ATR1.08327342
57KIT1.05068023
58TRIB31.03651014
59PLK11.02295088
60PLK40.98938430
61MAPK110.98847588
62SIK10.98578791
63BRD40.97373870
64PIM20.97240270
65PIK3CA0.96315846
66CSNK1A1L0.95569390
67RPS6KB20.95323268
68CDK80.95108663
69MAP3K110.91995995
70MAP3K100.90571071
71BTK0.89188555
72PAK40.87091444
73PASK0.86357901
74EEF2K0.85796985
75TEC0.85279547
76CCNB10.84047123
77ITK0.83040712
78CDK70.81611044
79TAF10.81456448
80PDK30.78364451
81PDK40.78364451
82IRAK20.77229609
83TAOK30.77123925
84BRSK10.76939162
85PLK30.76581818
86PIM10.76521092
87PTK60.75882802
88NME10.74462668
89MAP3K30.74403400
90TESK10.73700560
91STK40.70837414
92TAOK10.70553841
93PLK20.69224760
94GRK60.68360448
95IKBKB0.68142838
96JAK30.66646210
97TLK10.65532735
98GRK70.65326860
99OXSR10.63728380
100CSNK1G30.62572408
101STK38L0.62394847
102TAOK20.62205542
103ABL20.61147965
104BLK0.60587044
105CDK60.60571216
106EPHA20.58696082
107IKBKE0.58566294
108MAP3K50.57621453
109LATS10.57578445
110TNIK0.57151414
111MST1R0.56240487
112NEK60.55880181
113MKNK10.55690137
114WNK30.54889894
115CSF1R0.54195871
116AURKA0.53387030
117IRAK10.52597332
118CSNK2A10.51193111
119MAP3K140.49589055
120IRAK40.48645670
121CSNK2A20.47924916
122EIF2AK20.47215020
123CAMKK20.47034128
124STK240.46432198
125TGFBR20.45775544
126JAK20.42972251
127WNK40.41891052
128LCK0.41572702
129CHEK10.41410303
130MARK30.39635936
131ATM0.39519021
132MAP2K60.38799412
133ZAK0.38164443
134LYN0.37694159
135FGFR10.36787897
136CHEK20.36408939
137IRAK30.36338963
138MAP4K20.35353447
139CSK0.34850079
140CSNK1G10.33688508
141BMPR1B0.33296255

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.33738084
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87205776
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64636629
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50878116
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36444587
6One carbon pool by folate_Homo sapiens_hsa006702.35006585
7DNA replication_Homo sapiens_hsa030302.28081669
8Graft-versus-host disease_Homo sapiens_hsa053322.25282244
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10203874
10Arginine biosynthesis_Homo sapiens_hsa002202.06782990
11Fatty acid degradation_Homo sapiens_hsa000712.03005550
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94440300
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.92585791
14Tryptophan metabolism_Homo sapiens_hsa003801.92455377
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.91492208
16Primary immunodeficiency_Homo sapiens_hsa053401.90731639
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86067607
18Complement and coagulation cascades_Homo sapiens_hsa046101.85919968
19Nitrogen metabolism_Homo sapiens_hsa009101.85240006
20Selenocompound metabolism_Homo sapiens_hsa004501.84228218
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.82097807
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78881539
23Biosynthesis of amino acids_Homo sapiens_hsa012301.77013357
24Peroxisome_Homo sapiens_hsa041461.76796520
25Propanoate metabolism_Homo sapiens_hsa006401.68608059
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61840803
27Folate biosynthesis_Homo sapiens_hsa007901.61750394
28Proteasome_Homo sapiens_hsa030501.61159577
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60316834
30Carbon metabolism_Homo sapiens_hsa012001.59727701
31Caffeine metabolism_Homo sapiens_hsa002321.53847381
32Mismatch repair_Homo sapiens_hsa034301.52022636
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46989685
34Pyruvate metabolism_Homo sapiens_hsa006201.43696971
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42153711
36Pentose phosphate pathway_Homo sapiens_hsa000301.38529276
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37714111
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37288055
39Chemical carcinogenesis_Homo sapiens_hsa052041.34745534
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34124742
41Fatty acid metabolism_Homo sapiens_hsa012121.33970673
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33729536
43beta-Alanine metabolism_Homo sapiens_hsa004101.33145331
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31132206
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27638765
46Base excision repair_Homo sapiens_hsa034101.27396259
47Butanoate metabolism_Homo sapiens_hsa006501.23523246
48Histidine metabolism_Homo sapiens_hsa003401.22045149
49Retinol metabolism_Homo sapiens_hsa008301.22002167
50Phenylalanine metabolism_Homo sapiens_hsa003601.21820766
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.21737978
52Pyrimidine metabolism_Homo sapiens_hsa002401.20835768
53Sulfur relay system_Homo sapiens_hsa041221.19676410
54PPAR signaling pathway_Homo sapiens_hsa033201.16164698
55Staphylococcus aureus infection_Homo sapiens_hsa051501.11294780
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10827823
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08683287
58Glutathione metabolism_Homo sapiens_hsa004801.04595115
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02054196
60Starch and sucrose metabolism_Homo sapiens_hsa005001.01854808
61Tyrosine metabolism_Homo sapiens_hsa003501.00257864
62Shigellosis_Homo sapiens_hsa051310.97288762
63Oxidative phosphorylation_Homo sapiens_hsa001900.96178765
64Nucleotide excision repair_Homo sapiens_hsa034200.95598622
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94097884
66Allograft rejection_Homo sapiens_hsa053300.93725410
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.92519966
68Basal transcription factors_Homo sapiens_hsa030220.91922616
69Homologous recombination_Homo sapiens_hsa034400.91604306
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87910265
71Ribosome_Homo sapiens_hsa030100.87903530
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87517414
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87335378
74RNA transport_Homo sapiens_hsa030130.87218525
75Vitamin digestion and absorption_Homo sapiens_hsa049770.86437657
76Fat digestion and absorption_Homo sapiens_hsa049750.86253835
77Sulfur metabolism_Homo sapiens_hsa009200.83174776
78Hematopoietic cell lineage_Homo sapiens_hsa046400.82238394
79Fatty acid elongation_Homo sapiens_hsa000620.81544802
80RNA polymerase_Homo sapiens_hsa030200.81461949
81Arginine and proline metabolism_Homo sapiens_hsa003300.81087850
82Autoimmune thyroid disease_Homo sapiens_hsa053200.80863385
83Parkinsons disease_Homo sapiens_hsa050120.79001429
84Spliceosome_Homo sapiens_hsa030400.78503302
85Vitamin B6 metabolism_Homo sapiens_hsa007500.74128238
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71372485
87Steroid biosynthesis_Homo sapiens_hsa001000.70011041
88Cell cycle_Homo sapiens_hsa041100.69263705
89ABC transporters_Homo sapiens_hsa020100.68901293
90Pertussis_Homo sapiens_hsa051330.68225802
91Bile secretion_Homo sapiens_hsa049760.67525211
92Non-homologous end-joining_Homo sapiens_hsa034500.65994009
93Measles_Homo sapiens_hsa051620.64121777
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61522904
95T cell receptor signaling pathway_Homo sapiens_hsa046600.60830051
96Asthma_Homo sapiens_hsa053100.59178383
97Metabolic pathways_Homo sapiens_hsa011000.59102683
98Leishmaniasis_Homo sapiens_hsa051400.57758555
99Galactose metabolism_Homo sapiens_hsa000520.57244572
100Other glycan degradation_Homo sapiens_hsa005110.56452637
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.55819365
102Protein export_Homo sapiens_hsa030600.54201334
103Lysine degradation_Homo sapiens_hsa003100.54078392
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52656382
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51411583
106Fructose and mannose metabolism_Homo sapiens_hsa000510.51291944
107TNF signaling pathway_Homo sapiens_hsa046680.51091443
108Systemic lupus erythematosus_Homo sapiens_hsa053220.49015412
109Legionellosis_Homo sapiens_hsa051340.48902525
110Tuberculosis_Homo sapiens_hsa051520.47970341
111Type I diabetes mellitus_Homo sapiens_hsa049400.45323165
112RNA degradation_Homo sapiens_hsa030180.45299112
113Rheumatoid arthritis_Homo sapiens_hsa053230.44469300
114Huntingtons disease_Homo sapiens_hsa050160.44313842
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43866526
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43737475
117Purine metabolism_Homo sapiens_hsa002300.42469194
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41201712
119Salmonella infection_Homo sapiens_hsa051320.41084427
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41007213
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40788306
122Fanconi anemia pathway_Homo sapiens_hsa034600.40748456
123African trypanosomiasis_Homo sapiens_hsa051430.40630671
124mRNA surveillance pathway_Homo sapiens_hsa030150.37961203
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37880514
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.37653037
127N-Glycan biosynthesis_Homo sapiens_hsa005100.36385943
128Antigen processing and presentation_Homo sapiens_hsa046120.36125859
129Glycerolipid metabolism_Homo sapiens_hsa005610.35620243
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35502815
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34582096
132p53 signaling pathway_Homo sapiens_hsa041150.34237136
133Mineral absorption_Homo sapiens_hsa049780.34094095
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33095990
135Hepatitis B_Homo sapiens_hsa051610.32844962
136Influenza A_Homo sapiens_hsa051640.32373136
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26911798
138Herpes simplex infection_Homo sapiens_hsa051680.22175508
139Renin-angiotensin system_Homo sapiens_hsa046140.18029440
140Epstein-Barr virus infection_Homo sapiens_hsa051690.14210328
141Viral carcinogenesis_Homo sapiens_hsa052030.13085274

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