ZDHHC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.52524973
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.52524973
3L-phenylalanine metabolic process (GO:0006558)6.23560937
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.23560937
5aromatic amino acid family catabolic process (GO:0009074)5.48429999
6sulfur amino acid catabolic process (GO:0000098)5.07197605
7coenzyme catabolic process (GO:0009109)5.01021362
8alpha-linolenic acid metabolic process (GO:0036109)4.84924904
9glyoxylate metabolic process (GO:0046487)4.82241969
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.80910024
11cellular modified amino acid catabolic process (GO:0042219)4.77205961
12kynurenine metabolic process (GO:0070189)4.63473659
13bile acid biosynthetic process (GO:0006699)4.62983906
14tryptophan catabolic process (GO:0006569)4.55409530
15indole-containing compound catabolic process (GO:0042436)4.55409530
16indolalkylamine catabolic process (GO:0046218)4.55409530
17cysteine metabolic process (GO:0006534)4.35426178
18heme transport (GO:0015886)4.33579662
19negative regulation of fibrinolysis (GO:0051918)4.29105961
20tryptophan metabolic process (GO:0006568)4.23121670
21protein carboxylation (GO:0018214)4.19052710
22peptidyl-glutamic acid carboxylation (GO:0017187)4.19052710
23cellular ketone body metabolic process (GO:0046950)4.13751766
24urea metabolic process (GO:0019627)4.10942451
25urea cycle (GO:0000050)4.10942451
26high-density lipoprotein particle remodeling (GO:0034375)4.06893243
27regulation of fibrinolysis (GO:0051917)4.02551965
28bile acid metabolic process (GO:0008206)3.99563173
29fatty acid elongation (GO:0030497)3.98863868
30complement activation, alternative pathway (GO:0006957)3.85485656
31nitrogen cycle metabolic process (GO:0071941)3.84414585
32epoxygenase P450 pathway (GO:0019373)3.84301626
33aromatic amino acid family metabolic process (GO:0009072)3.82754489
34regulation of protein activation cascade (GO:2000257)3.80415668
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79217261
36cofactor catabolic process (GO:0051187)3.78552448
37regulation of triglyceride catabolic process (GO:0010896)3.78332035
38serine family amino acid catabolic process (GO:0009071)3.74578439
39alpha-amino acid catabolic process (GO:1901606)3.69797319
40plasma lipoprotein particle clearance (GO:0034381)3.68929992
41lysine catabolic process (GO:0006554)3.68076512
42lysine metabolic process (GO:0006553)3.68076512
43glutamate metabolic process (GO:0006536)3.66650896
44cellular amino acid catabolic process (GO:0009063)3.66247686
45tyrosine metabolic process (GO:0006570)3.63482269
46acetyl-CoA metabolic process (GO:0006084)3.56883641
47negative regulation of cholesterol transport (GO:0032375)3.56605646
48negative regulation of sterol transport (GO:0032372)3.56605646
49regulation of cholesterol esterification (GO:0010872)3.55894327
50regulation of complement activation (GO:0030449)3.55381720
51reverse cholesterol transport (GO:0043691)3.55121296
52ketone body metabolic process (GO:1902224)3.53529593
53protein retention in ER lumen (GO:0006621)3.53114418
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52752765
55very long-chain fatty acid metabolic process (GO:0000038)3.51650541
56drug metabolic process (GO:0017144)3.49698847
57triglyceride homeostasis (GO:0070328)3.43532012
58acylglycerol homeostasis (GO:0055090)3.43532012
59drug catabolic process (GO:0042737)3.42648088
60homocysteine metabolic process (GO:0050667)3.40658813
61short-chain fatty acid metabolic process (GO:0046459)3.40566761
62regulation of cholesterol homeostasis (GO:2000188)3.40161795
63plasma lipoprotein particle remodeling (GO:0034369)3.39512425
64protein-lipid complex remodeling (GO:0034368)3.39512425
65macromolecular complex remodeling (GO:0034367)3.39512425
66cholesterol efflux (GO:0033344)3.38470845
67ethanol oxidation (GO:0006069)3.36660554
68hormone catabolic process (GO:0042447)3.32829743
69central nervous system myelination (GO:0022010)3.31369058
70axon ensheathment in central nervous system (GO:0032291)3.31369058
71aspartate family amino acid catabolic process (GO:0009068)3.31348526
72pyrimidine nucleobase catabolic process (GO:0006208)3.28719930
73amino-acid betaine metabolic process (GO:0006577)3.26575473
74dicarboxylic acid biosynthetic process (GO:0043650)3.25799057
75phospholipid efflux (GO:0033700)3.25101673
76flavonoid metabolic process (GO:0009812)3.24195016
77fatty-acyl-CoA biosynthetic process (GO:0046949)3.21633656
78iron coordination entity transport (GO:1901678)3.20350689
79Golgi transport vesicle coating (GO:0048200)3.19403655
80COPI coating of Golgi vesicle (GO:0048205)3.19403655
81positive regulation of lipoprotein lipase activity (GO:0051006)3.17488844
82positive regulation of triglyceride lipase activity (GO:0061365)3.17488844
83cellular glucuronidation (GO:0052695)3.17332374
84bile acid and bile salt transport (GO:0015721)3.14575364
85serine family amino acid metabolic process (GO:0009069)3.13961684
86biotin metabolic process (GO:0006768)3.13502511
87regulation of bile acid biosynthetic process (GO:0070857)3.11576889
88primary alcohol catabolic process (GO:0034310)3.11306787
89organic acid catabolic process (GO:0016054)3.09851694
90carboxylic acid catabolic process (GO:0046395)3.09851694
91fibrinolysis (GO:0042730)3.09741034
92cholesterol homeostasis (GO:0042632)3.08909297
93arginine metabolic process (GO:0006525)3.08520361
94benzene-containing compound metabolic process (GO:0042537)3.07086497
95indolalkylamine metabolic process (GO:0006586)3.05427567
96long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.05098183
97sterol homeostasis (GO:0055092)3.04962381
98amine catabolic process (GO:0009310)3.04164230
99cellular biogenic amine catabolic process (GO:0042402)3.04164230
100serine family amino acid biosynthetic process (GO:0009070)3.02240512
101drug transmembrane transport (GO:0006855)2.98233052
102exogenous drug catabolic process (GO:0042738)2.98118611
103acyl-CoA biosynthetic process (GO:0071616)2.95372276
104thioester biosynthetic process (GO:0035384)2.95372276
105desmosome organization (GO:0002934)2.68872312
106regulation of cholesterol biosynthetic process (GO:0045540)2.52070307
107axon extension involved in axon guidance (GO:0048846)2.47931047
108neuron projection extension involved in neuron projection guidance (GO:1902284)2.47931047
109sodium ion export (GO:0071436)2.47471347
110gap junction assembly (GO:0016264)2.46781033
111skin morphogenesis (GO:0043589)2.46092900
112cell adhesion mediated by integrin (GO:0033627)2.44253663
113glutamate secretion (GO:0014047)2.43923865
114postsynaptic membrane organization (GO:0001941)2.37716556
115regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36817009
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31292879
117paraxial mesoderm development (GO:0048339)2.31018474
118vocalization behavior (GO:0071625)2.30170841
119cellular potassium ion homeostasis (GO:0030007)2.30091842
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29251227
121axonal fasciculation (GO:0007413)2.28570709
122hemidesmosome assembly (GO:0031581)2.24210465
123neuron recognition (GO:0008038)2.23185209
124layer formation in cerebral cortex (GO:0021819)2.22704119
125nucleobase catabolic process (GO:0046113)2.21599850
126axon extension (GO:0048675)2.21569134
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20659462
128cellular sodium ion homeostasis (GO:0006883)2.20408173
129proline biosynthetic process (GO:0006561)2.20132759
1304-hydroxyproline metabolic process (GO:0019471)2.15959839
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15224109
132peptidyl-proline hydroxylation (GO:0019511)2.14766944
133basement membrane organization (GO:0071711)2.14462910
134regulation of plasminogen activation (GO:0010755)2.13732109
135proline metabolic process (GO:0006560)2.13444659
136L-serine transport (GO:0015825)2.13431611
137synaptic vesicle docking involved in exocytosis (GO:0016081)2.13382524
138regulation of axon extension involved in axon guidance (GO:0048841)2.13351473
139daunorubicin metabolic process (GO:0044597)2.13305560
140polyketide metabolic process (GO:0030638)2.13305560
141doxorubicin metabolic process (GO:0044598)2.13305560
142G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.13057083
143cerebellar Purkinje cell layer development (GO:0021680)2.12736077
144negative regulation of keratinocyte proliferation (GO:0010839)2.12337513
145apical protein localization (GO:0045176)2.10937660
146cholesterol biosynthetic process (GO:0006695)2.10503370
147negative regulation of catenin import into nucleus (GO:0035414)2.08824820
148neuronal ion channel clustering (GO:0045161)2.08093698
149phosphate ion transmembrane transport (GO:0035435)2.07185726
150semaphorin-plexin signaling pathway (GO:0071526)2.05088341
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.05064970
152glutamine family amino acid biosynthetic process (GO:0009084)2.04966366
153cochlea morphogenesis (GO:0090103)2.04829714
154regulation of axon guidance (GO:1902667)2.04491183
155vesicle coating (GO:0006901)2.02357605
156ephrin receptor signaling pathway (GO:0048013)2.02115759
157intestinal cholesterol absorption (GO:0030299)1.99091362
158branching involved in salivary gland morphogenesis (GO:0060445)1.98184391
159COPII vesicle coating (GO:0048208)1.95612555
160response to hepatocyte growth factor (GO:0035728)1.93673921
161cellular response to hepatocyte growth factor stimulus (GO:0035729)1.93673921
162bundle of His cell to Purkinje myocyte communication (GO:0086069)1.93059921
163renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)1.92247267
164neuron projection extension (GO:1990138)1.92209019
165sterol biosynthetic process (GO:0016126)1.92084708
166positive regulation of dendritic spine morphogenesis (GO:0061003)1.91536786
167notochord development (GO:0030903)1.91185758
168protein maturation by protein folding (GO:0022417)1.90883947
169glucose 6-phosphate metabolic process (GO:0051156)1.90325893
170purine nucleotide transport (GO:0015865)1.90192436
171phosphate ion transport (GO:0006817)1.89987056
172Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.89951667
173cytoskeletal anchoring at plasma membrane (GO:0007016)1.89324579
174chondrocyte proliferation (GO:0035988)1.88981966
175regulation of cholesterol metabolic process (GO:0090181)1.88147364
176L-serine metabolic process (GO:0006563)1.86381255
177dendritic spine organization (GO:0097061)1.85518497
178aminoglycoside antibiotic metabolic process (GO:0030647)1.85215953
179regulation of establishment of planar polarity (GO:0090175)1.84866645
180negative regulation of lipase activity (GO:0060192)1.84359878
181cellular copper ion homeostasis (GO:0006878)1.84117111
182negative regulation of axon extension involved in axon guidance (GO:0048843)1.83054350
183very-low-density lipoprotein particle assembly (GO:0034379)1.82261331
184cell communication involved in cardiac conduction (GO:0086065)1.79551630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.40012296
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.53550640
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.65756768
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.47666434
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.73800171
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.47673740
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38435863
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.21981988
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.98781619
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88339440
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77587666
12ZNF263_19887448_ChIP-Seq_K562_Human2.30970354
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29768638
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24681773
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.13770411
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.13770411
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.13770411
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82053104
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.78889970
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.78528732
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73487817
22AR_21909140_ChIP-Seq_LNCAP_Human1.67754256
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67622704
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64930173
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.64601369
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62834236
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55745104
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.51634323
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.51482221
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49410415
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46665957
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43025700
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.41966421
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.34321295
35LXR_22292898_ChIP-Seq_THP-1_Human1.29762928
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29243633
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28515245
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28092091
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.28069322
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22510969
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21999030
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20686945
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20606577
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17010945
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16948984
46* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12361675
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11912869
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.11267337
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11227899
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10997910
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.10579186
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09889815
53SOX2_20726797_ChIP-Seq_SW620_Human1.06776130
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05977801
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05377745
56EZH2_22144423_ChIP-Seq_EOC_Human1.05049735
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04927030
58KDM2B_26808549_Chip-Seq_K562_Human1.04296984
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04194496
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.04169828
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03833739
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03833739
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03610542
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03049725
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.03000002
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.01997197
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.01866739
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00748032
69CLOCK_20551151_ChIP-Seq_293T_Human1.00621640
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99239480
71RING1B_27294783_Chip-Seq_ESCs_Mouse0.99166738
72ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98114627
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97183039
74MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96249540
75* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96009595
76RACK7_27058665_Chip-Seq_MCF-7_Human0.95016159
77TRIM28_21343339_ChIP-Seq_HEK293_Human0.94352202
78TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94307114
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93865336
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93653018
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93477461
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92891191
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92078924
84EP300_21415370_ChIP-Seq_HL-1_Mouse0.91985048
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91966859
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91081275
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90918224
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90717382
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89206709
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87562474
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87337395
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86657677
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86657677
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86008170
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85777706
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.85424446
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85321359
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85038024
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83951272
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.82607635
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82503370
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82328979
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82230943
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.81409699
105TCF4_18268006_ChIP-ChIP_LS174T_Human0.80870390
106* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80129210
107AHR_22903824_ChIP-Seq_MCF-7_Human0.79828104
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79090698
109GATA4_25053715_ChIP-Seq_YYC3_Human0.78585915
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.77760262
111CTCF_27219007_Chip-Seq_Bcells_Human0.77584045
112RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77233437
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76055640
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75588626
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74866318
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74797126
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.73601267
118HTT_18923047_ChIP-ChIP_STHdh_Human0.73242169
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73225185
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.72786867
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.72459028
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72291329
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71702250
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71090904
125SMC4_20622854_ChIP-Seq_HELA_Human0.71066956
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71056290
127RARB_27405468_Chip-Seq_BRAIN_Mouse0.70208855
128EOMES_21245162_ChIP-Seq_HESCs_Human0.69498665
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69224706
130* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68414376
131JARID2_20075857_ChIP-Seq_MESCs_Mouse0.67262421
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.67133029
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66953656
134CREB1_26743006_Chip-Seq_LNCaP_Human0.66911277
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.66876697
136P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66440135
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.66251414
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.65891701
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65799874
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.65165964
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.65065917
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.64941948
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64376133
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.63805589
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.63757718
146* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63332586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.83348183
2MP0002139_abnormal_hepatobiliary_system6.68855100
3MP0005085_abnormal_gallbladder_physiolo5.15813824
4MP0005365_abnormal_bile_salt4.97282697
5MP0008875_abnormal_xenobiotic_pharmacok4.51795794
6MP0003806_abnormal_nucleotide_metabolis3.50419759
7MP0009840_abnormal_foam_cell3.15800249
8MP0003252_abnormal_bile_duct3.15139504
9MP0003011_delayed_dark_adaptation2.87394672
10MP0010329_abnormal_lipoprotein_level2.81424396
11MP0005083_abnormal_biliary_tract2.62371111
12MP0008438_abnormal_cutaneous_collagen2.59581265
13MP0004272_abnormal_basement_membrane2.58461345
14MP0005332_abnormal_amino_acid2.46044636
15MP0000566_synostosis2.43895222
16MP0002254_reproductive_system_inflammat2.30963854
17MP0001666_abnormal_nutrient_absorption2.22484310
18MP0003195_calcinosis2.20176514
19MP0009780_abnormal_chondrocyte_physiolo2.10681215
20MP0010030_abnormal_orbit_morphology2.07167960
21MP0003191_abnormal_cellular_cholesterol2.01508489
22MP0002118_abnormal_lipid_homeostasis1.92656098
23MP0000920_abnormal_myelination1.89437864
24MP0004019_abnormal_vitamin_homeostasis1.88849755
25MP0003329_amyloid_beta_deposits1.87180609
26MP0003705_abnormal_hypodermis_morpholog1.85444918
27MP0003122_maternal_imprinting1.83313441
28MP0000537_abnormal_urethra_morphology1.78778497
29MP0000609_abnormal_liver_physiology1.78600199
30MP0005623_abnormal_meninges_morphology1.76244649
31MP0004264_abnormal_extraembryonic_tissu1.72223387
32MP0003690_abnormal_glial_cell1.70966975
33MP0005257_abnormal_intraocular_pressure1.63889116
34MP0005451_abnormal_body_composition1.60677346
35MP0004858_abnormal_nervous_system1.60142959
36MP0000604_amyloidosis1.58880862
37MP0001299_abnormal_eye_distance/1.58529525
38MP0005319_abnormal_enzyme/_coenzyme1.54939568
39MP0003880_abnormal_central_pattern1.54192456
40MP0005584_abnormal_enzyme/coenzyme_acti1.54131830
41MP0005275_abnormal_skin_tensile1.51695950
42MP0003941_abnormal_skin_development1.41751041
43MP0001529_abnormal_vocalization1.37796725
44MP0005423_abnormal_somatic_nervous1.33698365
45MP0003868_abnormal_feces_composition1.33047171
46MP0003123_paternal_imprinting1.29335942
47MP0003566_abnormal_cell_adhesion1.28520548
48MP0000534_abnormal_ureter_morphology1.26042958
49MP0003942_abnormal_urinary_system1.24492567
50MP0009384_cardiac_valve_regurgitation1.24399591
51MP0004043_abnormal_pH_regulation1.23441982
52MP0005409_darkened_coat_color1.23179619
53MP0005503_abnormal_tendon_morphology1.20845008
54MP0002249_abnormal_larynx_morphology1.16074730
55MP0000049_abnormal_middle_ear1.15072398
56MP0006082_CNS_inflammation1.14626857
57MP0000462_abnormal_digestive_system1.14388015
58MP0003656_abnormal_erythrocyte_physiolo1.12300781
59MP0000467_abnormal_esophagus_morphology1.11948475
60MP0003315_abnormal_perineum_morphology1.09981694
61MP0003755_abnormal_palate_morphology1.04816494
62MP0002697_abnormal_eye_size1.04451616
63MP0003385_abnormal_body_wall1.04267900
64MP0009643_abnormal_urine_homeostasis1.02750899
65MP0002233_abnormal_nose_morphology1.01793572
66MP0004270_analgesia1.01040917
67MP0004381_abnormal_hair_follicle1.00574312
68MP0003937_abnormal_limbs/digits/tail_de0.99683389
69MP0003635_abnormal_synaptic_transmissio0.98304927
70MP0002796_impaired_skin_barrier0.97748198
71MP0008961_abnormal_basal_metabolism0.96168235
72MP0004133_heterotaxia0.96167699
73MP0005508_abnormal_skeleton_morphology0.94258131
74MP0001177_atelectasis0.93140797
75MP0004885_abnormal_endolymph0.92929139
76MP0006035_abnormal_mitochondrial_morpho0.91271014
77MP0005187_abnormal_penis_morphology0.90509924
78MP0003861_abnormal_nervous_system0.90240838
79MP0002138_abnormal_hepatobiliary_system0.90021618
80MP0002734_abnormal_mechanical_nocicepti0.89256302
81MP0005075_abnormal_melanosome_morpholog0.88582573
82MP0002295_abnormal_pulmonary_circulatio0.87795898
83MP0002089_abnormal_postnatal_growth/wei0.86089579
84MP0002063_abnormal_learning/memory/cond0.85688567
85MP0002184_abnormal_innervation0.85434588
86MP0003115_abnormal_respiratory_system0.85120466
87MP0002938_white_spotting0.84961518
88MP0000598_abnormal_liver_morphology0.84917616
89MP0001346_abnormal_lacrimal_gland0.84714712
90MP0005248_abnormal_Harderian_gland0.84532133
91MP0004782_abnormal_surfactant_physiolog0.83247747
92MP0003632_abnormal_nervous_system0.82474152
93MP0002876_abnormal_thyroid_physiology0.81670575
94MP0002116_abnormal_craniofacial_bone0.80802900
95MP0003283_abnormal_digestive_organ0.80487950
96MP0010368_abnormal_lymphatic_system0.79238163
97MP0009250_abnormal_appendicular_skeleto0.78999318
98MP0003075_altered_response_to0.78627884
99MP0004233_abnormal_muscle_weight0.77806584
100MP0003890_abnormal_embryonic-extraembry0.77624004
101MP0002060_abnormal_skin_morphology0.77579275
102MP0002152_abnormal_brain_morphology0.77172733
103MP0003950_abnormal_plasma_membrane0.77126027
104MP0003935_abnormal_craniofacial_develop0.76309104
105MP0002332_abnormal_exercise_endurance0.76269220
106MP0002282_abnormal_trachea_morphology0.76084624
107MP0005266_abnormal_metabolism0.76025685
108MP0001958_emphysema0.76011755
109MP0003634_abnormal_glial_cell0.75610183
110MP0002896_abnormal_bone_mineralization0.75251452
111MP0009053_abnormal_anal_canal0.75233278
112MP0002572_abnormal_emotion/affect_behav0.74818646
113MP0009672_abnormal_birth_weight0.74564911
114MP0005023_abnormal_wound_healing0.73161400
115MP0002557_abnormal_social/conspecific_i0.72807735
116MP0010678_abnormal_skin_adnexa0.72002215
117MP0005501_abnormal_skin_physiology0.71892156
118MP0001984_abnormal_olfaction0.71336294
119MP0002882_abnormal_neuron_morphology0.70816304
120MP0001286_abnormal_eye_development0.68737066
121MP0001502_abnormal_circadian_rhythm0.68605732
122MP0003119_abnormal_digestive_system0.68288609
123MP0005499_abnormal_olfactory_system0.68224385
124MP0005394_taste/olfaction_phenotype0.68224385
125MP0008874_decreased_physiological_sensi0.66969466
126MP0000647_abnormal_sebaceous_gland0.66313499
127MP0005636_abnormal_mineral_homeostasis0.65105505
128MP0004142_abnormal_muscle_tone0.65015624
129MP0005376_homeostasis/metabolism_phenot0.64745311
130MP0003186_abnormal_redox_activity0.64651695
131MP0001849_ear_inflammation0.63377762
132MP0000579_abnormal_nail_morphology0.62413290
133MP0002229_neurodegeneration0.59569269
134MP0009764_decreased_sensitivity_to0.58702332
135MP0009765_abnormal_xenobiotic_induced0.58293323
136MP0003137_abnormal_impulse_conducting0.58288258
137MP0004130_abnormal_muscle_cell0.58030631
138MP0004185_abnormal_adipocyte_glucose0.56814394
139MP0000639_abnormal_adrenal_gland0.56443166
140MP0009763_increased_sensitivity_to0.56018945
141MP0009642_abnormal_blood_homeostasis0.55242302
142MP0003938_abnormal_ear_development0.55050212
143MP0001486_abnormal_startle_reflex0.54322608
144MP0005647_abnormal_sex_gland0.54046759
145MP0000778_abnormal_nervous_system0.53484656
146MP0000383_abnormal_hair_follicle0.52598763
147MP0000762_abnormal_tongue_morphology0.51259074
148MP0002092_abnormal_eye_morphology0.50469722
149MP0005058_abnormal_lysosome_morphology0.50231164
150MP0003172_abnormal_lysosome_physiology0.49539006
151MP0006036_abnormal_mitochondrial_physio0.48992527
152MP0002098_abnormal_vibrissa_morphology0.48332515
153MP0000377_abnormal_hair_follicle0.46893206
154MP0005448_abnormal_energy_balance0.46890341
155MP0002090_abnormal_vision0.46570724
156MP0004883_abnormal_blood_vessel0.46269087
157MP0002971_abnormal_brown_adipose0.46019123
158MP0003183_abnormal_peptide_metabolism0.45933397
159MP0002269_muscular_atrophy0.45626463
160MP0001756_abnormal_urination0.45419260
161MP0002078_abnormal_glucose_homeostasis0.45370920
162MP0003453_abnormal_keratinocyte_physiol0.44247430
163MP0004859_abnormal_synaptic_plasticity0.44153668
164MP0005535_abnormal_body_temperature0.43592002
165MP0005666_abnormal_adipose_tissue0.43256486
166MP0003633_abnormal_nervous_system0.43255856
167MP0000955_abnormal_spinal_cord0.43114044
168MP0003631_nervous_system_phenotype0.42836405
169MP0002064_seizures0.42246888
170MP0001764_abnormal_homeostasis0.41778660
171MP0001348_abnormal_lacrimal_gland0.41594175

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.97855598
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.96777517
3Intrahepatic cholestasis (HP:0001406)5.90577252
4Xanthomatosis (HP:0000991)5.20973025
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.77523531
6Hypobetalipoproteinemia (HP:0003563)4.31132486
7Prolonged partial thromboplastin time (HP:0003645)4.31121611
8Hypochromic microcytic anemia (HP:0004840)4.30751146
9Hyperlipoproteinemia (HP:0010980)4.30364290
10Complement deficiency (HP:0004431)3.99039605
11Hyperammonemia (HP:0001987)3.75478274
12Abnormality of glycine metabolism (HP:0010895)3.69788212
13Abnormality of serine family amino acid metabolism (HP:0010894)3.69788212
14Ketosis (HP:0001946)3.64679352
15Epidermoid cyst (HP:0200040)3.60055019
16Hyperglycinuria (HP:0003108)3.49203986
17Premature rupture of membranes (HP:0001788)3.38460629
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36420537
19Neurofibrillary tangles (HP:0002185)3.36012502
20Hepatoblastoma (HP:0002884)3.35114230
21Hyperglycinemia (HP:0002154)3.33256026
22Hypolipoproteinemia (HP:0010981)3.28000064
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.26337051
24Abnormality of the intrinsic pathway (HP:0010989)3.22463921
25Joint hemorrhage (HP:0005261)3.22310146
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10602525
27Fat malabsorption (HP:0002630)3.07243383
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06215670
29Skin nodule (HP:0200036)3.03866937
30Protrusio acetabuli (HP:0003179)3.03149652
31Gout (HP:0001997)3.01507096
32Abnormality of the corticospinal tract (HP:0002492)3.00767263
33Hypoalphalipoproteinemia (HP:0003233)2.99371266
34Abnormality of methionine metabolism (HP:0010901)2.91818479
35Malnutrition (HP:0004395)2.91762731
36Abnormality of complement system (HP:0005339)2.87971540
37Delayed CNS myelination (HP:0002188)2.85984048
38Hyperventilation (HP:0002883)2.81393327
39Hypercholesterolemia (HP:0003124)2.79864049
40Abnormality of the common coagulation pathway (HP:0010990)2.79598687
41Abnormality of the lower motor neuron (HP:0002366)2.79435268
42Sensory axonal neuropathy (HP:0003390)2.76057431
43Ketoacidosis (HP:0001993)2.71906400
44Cerebral inclusion bodies (HP:0100314)2.71013180
45Spastic tetraparesis (HP:0001285)2.67778519
46Abnormality of the Achilles tendon (HP:0005109)2.66825591
47Amyloidosis (HP:0011034)2.63939750
48Shallow orbits (HP:0000586)2.58671070
49Abnormality of dentin (HP:0010299)2.52355839
50Bilateral microphthalmos (HP:0007633)2.51985497
51Hyperinsulinemic hypoglycemia (HP:0000825)2.49424455
52Irritability (HP:0000737)2.45394180
53Conjugated hyperbilirubinemia (HP:0002908)2.42789524
54Metabolic acidosis (HP:0001942)2.42724671
55Abnormal cartilage morphology (HP:0002763)2.41452670
56Vascular calcification (HP:0004934)2.39363060
57Increased serum pyruvate (HP:0003542)2.36041299
58Abnormality of glycolysis (HP:0004366)2.36041299
59Coronal craniosynostosis (HP:0004440)2.35697186
60Cholecystitis (HP:0001082)2.35317918
61Abnormal gallbladder physiology (HP:0012438)2.35317918
62Rickets (HP:0002748)2.34373722
63Vascular tortuosity (HP:0004948)2.34284481
64Abnormality of fatty-acid metabolism (HP:0004359)2.32075529
65Arterial tortuosity (HP:0005116)2.31998842
66Hyperbilirubinemia (HP:0002904)2.31566557
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29900871
68Steatorrhea (HP:0002570)2.28831072
69Abnormal gallbladder morphology (HP:0012437)2.28704121
70Abnormality of purine metabolism (HP:0004352)2.26391506
71Cholelithiasis (HP:0001081)2.24825009
72Status epilepticus (HP:0002133)2.24285591
73Atrophic scars (HP:0001075)2.16380654
74Axonal loss (HP:0003447)2.15730864
75Cardiovascular calcification (HP:0011915)2.15626827
76Right ventricular cardiomyopathy (HP:0011663)2.14555125
77Distal upper limb amyotrophy (HP:0007149)2.12672814
78Upper limb amyotrophy (HP:0009129)2.12672814
79Hypophosphatemic rickets (HP:0004912)2.11496699
80Hand muscle atrophy (HP:0009130)2.11255472
81Achilles tendon contracture (HP:0001771)2.11100340
82Peritonitis (HP:0002586)2.09576005
83Abnormality of nucleobase metabolism (HP:0010932)2.07708167
84Aplasia involving bones of the extremities (HP:0009825)2.06098923
85Aplasia involving bones of the upper limbs (HP:0009823)2.06098923
86Aplasia of the phalanges of the hand (HP:0009802)2.06098923
87Hypoglycemic coma (HP:0001325)2.05921187
88Tetraplegia (HP:0002445)2.05310865
89Bladder diverticulum (HP:0000015)2.04774263
90Intention tremor (HP:0002080)2.03493627
91Hepatocellular carcinoma (HP:0001402)2.02838348
92Myocardial infarction (HP:0001658)2.02664680
93Bronchomalacia (HP:0002780)2.02292574
94Neonatal short-limb short stature (HP:0008921)2.02259308
95Systemic lupus erythematosus (HP:0002725)2.01013033
96Spastic paraparesis (HP:0002313)2.00608473
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00350428
98Dicarboxylic aciduria (HP:0003215)2.00350428
99Abnormal enzyme/coenzyme activity (HP:0012379)1.99095081
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.98130536
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98130536
102Myokymia (HP:0002411)1.97734556
103Pseudobulbar signs (HP:0002200)1.96434307
104Action tremor (HP:0002345)1.95981034
105Split foot (HP:0001839)1.93099847
106Abnormality of serum amino acid levels (HP:0003112)1.93087190
107Ragged-red muscle fibers (HP:0003200)1.92612260
108Follicular hyperkeratosis (HP:0007502)1.91347689
109Turricephaly (HP:0000262)1.90291908
110Cervical subluxation (HP:0003308)1.89955419
111Morphological abnormality of the pyramidal tract (HP:0002062)1.88793055
112Vomiting (HP:0002013)1.88508437
113Multiple enchondromatosis (HP:0005701)1.87514162
114Broad metatarsal (HP:0001783)1.87349261
115Abnormality of carpal bone ossification (HP:0006257)1.87087301
116Supranuclear gaze palsy (HP:0000605)1.83215770
117Pterygium (HP:0001059)1.83161148
118Back pain (HP:0003418)1.80870199
119Upper motor neuron abnormality (HP:0002127)1.80269391
120Peripheral demyelination (HP:0011096)1.79887945
121Abnormality of alkaline phosphatase activity (HP:0004379)1.78466044
122Microglossia (HP:0000171)1.77629144
123Hammertoe (HP:0001765)1.77251011
124Lethargy (HP:0001254)1.76866944
125Sensorimotor neuropathy (HP:0007141)1.76523522
126Mitral stenosis (HP:0001718)1.75954464
127Elevated alkaline phosphatase (HP:0003155)1.75277416
128Abnormality of vitamin metabolism (HP:0100508)1.75136477
129Abnormality of the gallbladder (HP:0005264)1.74215078
130Ankle contracture (HP:0006466)1.74167664
131Insomnia (HP:0100785)1.70874268
132Renal duplication (HP:0000075)1.69112909
133Impaired pain sensation (HP:0007328)1.68385294
134Abnormality of pain sensation (HP:0010832)1.68385294
135Cortical dysplasia (HP:0002539)1.68161061
136Ulnar bowing (HP:0003031)1.66543775
137Termporal pattern (HP:0011008)1.65747459
138Insidious onset (HP:0003587)1.65747459
139Soft skin (HP:0000977)1.64554983
140Arnold-Chiari malformation (HP:0002308)1.64446606
141Fragile skin (HP:0001030)1.63170240
142Overriding aorta (HP:0002623)1.62268900
143Aortic dissection (HP:0002647)1.62128829
144Bifid scrotum (HP:0000048)1.61046799
145Short nail (HP:0001799)1.60584634
146Wormian bones (HP:0002645)1.59862823
147Infantile muscular hypotonia (HP:0008947)1.59790337
148Spinal rigidity (HP:0003306)1.59493491
149Hypoplastic pelvis (HP:0008839)1.58782393
150Premature skin wrinkling (HP:0100678)1.58083536
151Abnormal ossification of hand bones (HP:0005921)1.56347653
152Hyperacusis (HP:0010780)1.53691583
153Choanal stenosis (HP:0000452)1.53327900
154Abnormal delivery (HP:0001787)1.53046010
155Partial duplication of thumb phalanx (HP:0009944)1.51603570
156Abnormal hand bone ossification (HP:0010660)1.50364601
157Torticollis (HP:0000473)1.49887825
158Hyperextensible skin (HP:0000974)1.49116242
159Flat acetabular roof (HP:0003180)1.46729116
160Partial duplication of the phalanx of hand (HP:0009999)1.44572347
161Abnormality of molar (HP:0011077)1.43381285
162Abnormality of molar morphology (HP:0011070)1.43381285
163Alacrima (HP:0000522)1.42847488
164Hypoventilation (HP:0002791)1.41618286
165Mixed hearing impairment (HP:0000410)1.40204495
166Abnormality of permanent molar morphology (HP:0011071)1.39679287
167Abnormality of the dental root (HP:0006486)1.39679287
168Taurodontia (HP:0000679)1.39679287
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.38313502
170Vertebral compression fractures (HP:0002953)1.38190013
171Mitral regurgitation (HP:0001653)1.37714179
172Generalized hypotonia (HP:0001290)1.37145098
173Nuclear cataract (HP:0100018)1.36263718
174Advanced eruption of teeth (HP:0006288)1.35730917
175Mildly elevated creatine phosphokinase (HP:0008180)1.34070416
176Myelomeningocele (HP:0002475)1.33814678
177Broad alveolar ridges (HP:0000187)1.33627450
178Fragile nails (HP:0001808)1.31961988
179Polyphagia (HP:0002591)1.29364837
180Congenital glaucoma (HP:0001087)1.28769383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.95200164
2CDK123.97699799
3EPHA22.97458104
4CASK2.56510681
5STK392.53533465
6EPHB12.48578227
7GRK52.47414319
8OXSR12.39751905
9BCKDK2.34339119
10TYRO32.28972999
11SIK12.09714427
12GRK62.09510172
13WNK11.95637916
14ICK1.90894522
15CSF1R1.89959989
16LMTK21.88121812
17TESK11.86778994
18PRKD31.84984782
19MAP3K91.84901185
20NTRK11.81726422
21FGFR21.72128147
22PRPF4B1.69545484
23MAP2K41.67005024
24FGFR41.62258503
25MAPK71.58301571
26MET1.53545662
27TGFBR21.53114109
28GRK11.49883919
29PBK1.39270096
30MARK11.33861232
31WNK41.32274624
32CDK191.28919771
33BCR1.26802756
34MATK1.24000139
35ERBB41.23326146
36PKN11.23107900
37MARK21.22070560
38MINK11.19369075
39PAK61.18685305
40PAK31.10845483
41MAP2K71.10101803
42ADRBK21.09741262
43MAP3K71.09584880
44EPHA41.05819042
45TNIK1.04810426
46DMPK0.99707130
47CAMK1D0.96957767
48GRK70.95477091
49MAPK120.94563566
50PNCK0.93163938
51NTRK30.92593561
52FER0.92255687
53PTK20.91840176
54CAMK40.91469614
55PAK40.90844558
56UHMK10.87787198
57BMX0.87243224
58CAMK1G0.83782471
59MOS0.83719378
60FGFR10.83126718
61CAMK2B0.82964564
62CSNK1A1L0.81241818
63KSR20.81059392
64ERBB20.79685631
65PLK20.78305169
66DDR20.76919778
67CSK0.75933913
68DAPK20.75690808
69CSNK1G30.75272925
70PRKG20.75221318
71FGR0.74548595
72PAK20.73264859
73DYRK20.71608053
74TSSK60.71540839
75TRIB30.71049531
76CSNK1G20.70647129
77STK100.70578444
78PIK3CA0.70166150
79NEK10.69593685
80MST1R0.68702592
81CAMK2D0.68429290
82ARAF0.68307079
83LATS10.68258382
84MAP3K40.68047125
85PRKCG0.66454707
86PHKG10.65090114
87PHKG20.65090114
88RIPK10.63326548
89BRSK10.62884112
90CSNK1G10.62160239
91MAP3K100.61630669
92GSK3A0.60445031
93PDK20.60067116
94ILK0.59683705
95EPHB20.59325512
96LATS20.58356833
97PDPK10.58272806
98STK380.56400059
99PRKD10.55933063
100MTOR0.55344745
101EIF2AK10.55028023
102PRKCI0.54789230
103EPHA30.54263132
104PDGFRB0.54206686
105WNK30.53994967
106PIM20.53391693
107MAPKAPK50.53130217
108ABL20.53089403
109PRKACG0.52235963
110TRIM280.52070382
111PRKCE0.51176370
112CDK150.50894323
113TESK20.50629065
114CDK50.50132262
115CDK180.49363815
116CSNK1E0.49100957
117IRAK30.48877191
118CDK140.48348465
119CAMK2G0.48254547
120PRKCZ0.47515516
121MAPK40.47462591
122FYN0.46830138
123AKT30.46715718
124RET0.46509256
125PDK10.45417228
126FGFR30.45405981
127SGK4940.45329300
128SGK2230.45329300
129PRKCQ0.44126167
130LIMK10.43705998
131STK38L0.43478181
132MAP2K60.43240337
133NTRK20.43157465
134ROCK20.42720147
135PDGFRA0.42612627
136PTK60.42530957
137CDK11A0.41101880
138DYRK1B0.40494182
139JAK20.40209120
140MAP3K120.40056388
141PRKAA20.39554110
142PKN20.38789477
143EGFR0.38562552
144DYRK1A0.38340536

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71163382
2Nitrogen metabolism_Homo sapiens_hsa009103.52060236
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.97507898
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85036020
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69824173
6Arginine biosynthesis_Homo sapiens_hsa002202.63385698
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52354928
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49131470
9Tryptophan metabolism_Homo sapiens_hsa003802.43059157
10Butanoate metabolism_Homo sapiens_hsa006502.41973899
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32783359
12Complement and coagulation cascades_Homo sapiens_hsa046102.32269938
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25331835
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14528876
15Fatty acid degradation_Homo sapiens_hsa000712.10643827
16Steroid biosynthesis_Homo sapiens_hsa001002.06650643
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02587730
18Fatty acid elongation_Homo sapiens_hsa000621.92234963
19Vitamin B6 metabolism_Homo sapiens_hsa007501.87426130
20Histidine metabolism_Homo sapiens_hsa003401.86960958
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84154309
22Chemical carcinogenesis_Homo sapiens_hsa052041.82368685
23Fatty acid metabolism_Homo sapiens_hsa012121.81945016
24Peroxisome_Homo sapiens_hsa041461.78356665
25PPAR signaling pathway_Homo sapiens_hsa033201.75855345
26Propanoate metabolism_Homo sapiens_hsa006401.74266023
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.65515212
28Bile secretion_Homo sapiens_hsa049761.65213908
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60943830
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48472891
31Retinol metabolism_Homo sapiens_hsa008301.45646033
32beta-Alanine metabolism_Homo sapiens_hsa004101.40697792
33Caffeine metabolism_Homo sapiens_hsa002321.40337842
34Staphylococcus aureus infection_Homo sapiens_hsa051501.38301522
35Sulfur metabolism_Homo sapiens_hsa009201.36464313
36Vibrio cholerae infection_Homo sapiens_hsa051101.29810138
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29559983
38ECM-receptor interaction_Homo sapiens_hsa045121.22104151
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19098336
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17325588
41Fat digestion and absorption_Homo sapiens_hsa049751.12130625
42Pyruvate metabolism_Homo sapiens_hsa006201.11916660
43Hippo signaling pathway_Homo sapiens_hsa043901.10139778
44Starch and sucrose metabolism_Homo sapiens_hsa005001.07544599
45ABC transporters_Homo sapiens_hsa020101.03843434
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.02319871
47Folate biosynthesis_Homo sapiens_hsa007901.01999549
48Phenylalanine metabolism_Homo sapiens_hsa003601.01775411
49Adherens junction_Homo sapiens_hsa045201.01431168
50Tyrosine metabolism_Homo sapiens_hsa003501.01066059
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00921763
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00296916
53Tight junction_Homo sapiens_hsa045301.00217506
54Arginine and proline metabolism_Homo sapiens_hsa003300.99856871
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98938908
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95837790
57Synaptic vesicle cycle_Homo sapiens_hsa047210.95294839
58Basal cell carcinoma_Homo sapiens_hsa052170.94913557
59Cocaine addiction_Homo sapiens_hsa050300.92452448
60Carbon metabolism_Homo sapiens_hsa012000.92174717
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.89056676
62Selenocompound metabolism_Homo sapiens_hsa004500.88325938
63Biosynthesis of amino acids_Homo sapiens_hsa012300.87581634
64Vitamin digestion and absorption_Homo sapiens_hsa049770.85104608
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.80482113
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80277774
67Glycerolipid metabolism_Homo sapiens_hsa005610.79182318
68Hedgehog signaling pathway_Homo sapiens_hsa043400.77361939
69Thyroid hormone synthesis_Homo sapiens_hsa049180.76193722
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73477339
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73350457
72Lysine degradation_Homo sapiens_hsa003100.73150867
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.72994901
74Sulfur relay system_Homo sapiens_hsa041220.70927303
75Linoleic acid metabolism_Homo sapiens_hsa005910.67565689
76Fructose and mannose metabolism_Homo sapiens_hsa000510.66349528
77N-Glycan biosynthesis_Homo sapiens_hsa005100.66191504
78Wnt signaling pathway_Homo sapiens_hsa043100.66159624
79Fatty acid biosynthesis_Homo sapiens_hsa000610.64876674
80Dopaminergic synapse_Homo sapiens_hsa047280.63843472
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63385311
82Glutathione metabolism_Homo sapiens_hsa004800.62722138
83Nicotine addiction_Homo sapiens_hsa050330.61245263
84Melanogenesis_Homo sapiens_hsa049160.59986930
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59788357
86Focal adhesion_Homo sapiens_hsa045100.59710790
87Gap junction_Homo sapiens_hsa045400.59438830
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59254497
89Glucagon signaling pathway_Homo sapiens_hsa049220.54837030
90Protein export_Homo sapiens_hsa030600.53078748
91TGF-beta signaling pathway_Homo sapiens_hsa043500.52931699
92Ether lipid metabolism_Homo sapiens_hsa005650.52774914
93Sphingolipid metabolism_Homo sapiens_hsa006000.52355320
94Insulin secretion_Homo sapiens_hsa049110.51579029
95Amphetamine addiction_Homo sapiens_hsa050310.51151358
96Proteoglycans in cancer_Homo sapiens_hsa052050.49726947
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47461860
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.44454195
99Prion diseases_Homo sapiens_hsa050200.44314052
100Galactose metabolism_Homo sapiens_hsa000520.40035104
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38014049
102Metabolic pathways_Homo sapiens_hsa011000.36732423
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.35939347
104Pentose phosphate pathway_Homo sapiens_hsa000300.35746613
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35719233
106Arachidonic acid metabolism_Homo sapiens_hsa005900.31785901
107Axon guidance_Homo sapiens_hsa043600.28394684
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26316566
109Ovarian steroidogenesis_Homo sapiens_hsa049130.25012659
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.23083921
111Insulin resistance_Homo sapiens_hsa049310.18082874
112AMPK signaling pathway_Homo sapiens_hsa041520.17198856
113GABAergic synapse_Homo sapiens_hsa047270.15202679
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.15196535
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.11027034
116Lysosome_Homo sapiens_hsa041420.09535146
117Renin-angiotensin system_Homo sapiens_hsa046140.07143308
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06459155
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06387921
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06165854
121Mineral absorption_Homo sapiens_hsa049780.05352343
122Protein digestion and absorption_Homo sapiens_hsa049740.03986384
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03515149
124Choline metabolism in cancer_Homo sapiens_hsa052310.02723094
125Renal cell carcinoma_Homo sapiens_hsa052110.01318774
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.00996892
127Dorso-ventral axis formation_Homo sapiens_hsa043200.00983248
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0369993
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0083798
130Glutamatergic synapse_Homo sapiens_hsa04724-0.0034106

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