ZEB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.51017189
2presynaptic membrane organization (GO:0097090)4.04524518
3locomotory exploration behavior (GO:0035641)3.98742083
4ventricular trabecula myocardium morphogenesis (GO:0003222)3.76801521
5pyrimidine nucleobase catabolic process (GO:0006208)3.55890543
6dermatan sulfate biosynthetic process (GO:0030208)3.44326843
7interkinetic nuclear migration (GO:0022027)3.41154099
8establishment of nucleus localization (GO:0040023)3.36791943
9regulation of synapse structural plasticity (GO:0051823)3.35122687
10dermatan sulfate metabolic process (GO:0030205)3.32341410
11artery development (GO:0060840)3.30377804
12central nervous system projection neuron axonogenesis (GO:0021952)3.28133568
13Notch signaling involved in heart development (GO:0061314)3.25114840
14cardiac myofibril assembly (GO:0055003)3.13849325
15C4-dicarboxylate transport (GO:0015740)3.12355184
16negative regulation of protein localization to cell surface (GO:2000009)3.11070733
17heart trabecula morphogenesis (GO:0061384)3.06638808
18membrane assembly (GO:0071709)3.06172983
19appendage development (GO:0048736)3.05452393
20limb development (GO:0060173)3.05452393
21cerebral cortex radially oriented cell migration (GO:0021799)3.05235234
22heart valve formation (GO:0003188)3.01172553
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99185367
24vascular endothelial growth factor signaling pathway (GO:0038084)2.96431213
25limb bud formation (GO:0060174)2.93427293
26plasma membrane repair (GO:0001778)2.93381490
27epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.91767738
28negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90705118
29nucleus localization (GO:0051647)2.90564880
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89506360
31neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89409805
32central nervous system neuron axonogenesis (GO:0021955)2.88942557
33layer formation in cerebral cortex (GO:0021819)2.86704879
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85374159
35cell communication by electrical coupling (GO:0010644)2.84466272
36endocardial cushion morphogenesis (GO:0003203)2.84124731
37exploration behavior (GO:0035640)2.83540417
38sequestering of extracellular ligand from receptor (GO:0035581)2.81695514
39axon extension involved in axon guidance (GO:0048846)2.80406139
40neuron projection extension involved in neuron projection guidance (GO:1902284)2.80406139
41regulation of sarcomere organization (GO:0060297)2.79846483
42dendrite morphogenesis (GO:0048813)2.78716954
43transmission of nerve impulse (GO:0019226)2.78406309
44innervation (GO:0060384)2.77230539
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75151624
46prepulse inhibition (GO:0060134)2.73907793
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73148668
48mesenchymal cell development (GO:0014031)2.72941421
49chondroitin sulfate catabolic process (GO:0030207)2.72384100
50insulin-like growth factor receptor signaling pathway (GO:0048009)2.72382426
51negative regulation of axon extension involved in axon guidance (GO:0048843)2.71196258
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69357839
53negative regulation of axon guidance (GO:1902668)2.68799432
54endothelial cell differentiation (GO:0045446)2.67412907
55ganglion development (GO:0061548)2.67262944
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66821935
57chondrocyte proliferation (GO:0035988)2.66396150
58regulation of glutamate receptor signaling pathway (GO:1900449)2.66241421
59synaptic vesicle maturation (GO:0016188)2.66067405
60retinal ganglion cell axon guidance (GO:0031290)2.65227358
61mechanosensory behavior (GO:0007638)2.63339988
62vocalization behavior (GO:0071625)2.63122431
63actin-myosin filament sliding (GO:0033275)2.63009358
64muscle filament sliding (GO:0030049)2.63009358
65aorta morphogenesis (GO:0035909)2.62686571
66calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.61547653
67mesenchyme morphogenesis (GO:0072132)2.60628179
68DNA damage induced protein phosphorylation (GO:0006975)2.59768115
69cell migration involved in heart development (GO:0060973)2.58209820
70heart morphogenesis (GO:0003007)2.57612509
71actin-mediated cell contraction (GO:0070252)2.57198773
72neuronal stem cell maintenance (GO:0097150)2.56256314
73regulation of axon extension involved in axon guidance (GO:0048841)2.56236625
74nucleobase catabolic process (GO:0046113)2.55792945
75spinal cord development (GO:0021510)2.54868348
76cardiac cell development (GO:0055006)2.50932804
77regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49629475
78negative regulation of vascular permeability (GO:0043116)2.49612521
79cardiac muscle cell development (GO:0055013)2.49113474
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48725679
81ventricular septum morphogenesis (GO:0060412)2.48568006
82positive regulation of cardiac muscle cell differentiation (GO:2000727)2.47273056
83regulation of membrane repolarization (GO:0060306)2.47157530
84auditory behavior (GO:0031223)2.47031613
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47028160
86blood vessel maturation (GO:0001955)2.46456767
87otic vesicle formation (GO:0030916)2.42568175
88neuron cell-cell adhesion (GO:0007158)2.42288388
89cardiac epithelial to mesenchymal transition (GO:0060317)2.42277946
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42236968
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.42236968
92regulation of translation, ncRNA-mediated (GO:0045974)2.42236968
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41430114
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41150937
95glial cell proliferation (GO:0014009)2.40778809
96activation of protein kinase A activity (GO:0034199)2.40676581
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40382297
98cerebral cortex cell migration (GO:0021795)2.40356724
99lymph vessel development (GO:0001945)2.40321661
100negative regulation of sodium ion transport (GO:0010766)2.40108194
101neuromuscular synaptic transmission (GO:0007274)2.39824899
102positive regulation of glycogen biosynthetic process (GO:0045725)2.39590586
103stem cell development (GO:0048864)2.39441340
104tongue development (GO:0043586)2.39352951
105regulation of axon guidance (GO:1902667)2.38885158
106trabecula morphogenesis (GO:0061383)2.38779296
107myofibril assembly (GO:0030239)2.38773801
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38279952
109neural crest cell development (GO:0014032)2.38136722
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38107468
111atrial cardiac muscle cell action potential (GO:0086014)2.37902366
112postsynaptic membrane organization (GO:0001941)2.36888491
113regulation of cell communication by electrical coupling (GO:0010649)2.35120607
114cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35004524
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.34746852
116coronary vasculature morphogenesis (GO:0060977)2.34615632
117regulation of relaxation of muscle (GO:1901077)2.34454971
118response to gravity (GO:0009629)2.34053180
119response to inactivity (GO:0014854)2.33908555
120cell proliferation involved in metanephros development (GO:0072203)2.33751675
121kidney mesenchyme development (GO:0072074)2.33487600
122peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.32843253
123cerebral cortex neuron differentiation (GO:0021895)2.32116049
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.32099894
125response to auditory stimulus (GO:0010996)2.31904637
126forebrain neuron differentiation (GO:0021879)2.31080663
127regulation of cardiac muscle cell contraction (GO:0086004)2.30839299
128olfactory bulb development (GO:0021772)2.30692761
129fibroblast migration (GO:0010761)2.29985367
130somite development (GO:0061053)2.29957632
131axonal fasciculation (GO:0007413)2.29573111
132negative regulation of transcription regulatory region DNA binding (GO:2000678)2.28691632
133venous blood vessel morphogenesis (GO:0048845)2.28606607
134myoblast fusion (GO:0007520)2.28568079
135collagen fibril organization (GO:0030199)2.28188979
136cardiac right ventricle morphogenesis (GO:0003215)2.28022143
137positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27094454
138regulation of actin filament-based movement (GO:1903115)2.24923006
139glomerular filtration (GO:0003094)2.23149925
140regulation of dendritic spine morphogenesis (GO:0061001)2.20313465
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.20278049
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.20219051
143regulation of long-term neuronal synaptic plasticity (GO:0048169)2.20053300
144positive regulation of potassium ion transmembrane transport (GO:1901381)2.19959254
145hippo signaling (GO:0035329)2.19358035
146dendritic spine morphogenesis (GO:0060997)2.17963593
147lymphangiogenesis (GO:0001946)2.16898637
148regulation of synaptic transmission, glutamatergic (GO:0051966)2.15300619
149negative regulation of catenin import into nucleus (GO:0035414)2.14647658
150chondrocyte development (GO:0002063)2.13566108
151chondroitin sulfate biosynthetic process (GO:0030206)2.13465998
152negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.12730361
153ovulation cycle (GO:0042698)2.12481193
154cardiac muscle contraction (GO:0060048)2.12397991
155neurotransmitter-gated ion channel clustering (GO:0072578)2.12018430
156cerebellar Purkinje cell differentiation (GO:0021702)2.11633646
157protein heterotrimerization (GO:0070208)2.08435146
158cAMP biosynthetic process (GO:0006171)2.07252234
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.06383940
160negative regulation of oligodendrocyte differentiation (GO:0048715)2.06141209
161potassium ion import (GO:0010107)2.05818631
162negative regulation of smoothened signaling pathway (GO:0045879)2.05788481
163protein localization to synapse (GO:0035418)2.05625414
164myelination in peripheral nervous system (GO:0022011)2.04618243
165peripheral nervous system axon ensheathment (GO:0032292)2.04618243
166positive regulation of axon extension (GO:0045773)2.03777325
167retina vasculature morphogenesis in camera-type eye (GO:0061299)2.03650468
168neuron recognition (GO:0008038)2.03528965
169patterning of blood vessels (GO:0001569)2.02893630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92473646
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73077020
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63112903
4GBX2_23144817_ChIP-Seq_PC3_Human2.55413585
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52066096
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48538851
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48538851
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44985802
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.40728939
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38055400
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35240705
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.30959562
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.30046022
14AR_21572438_ChIP-Seq_LNCaP_Human2.28071984
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27229768
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15487395
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15467773
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03915693
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.01373410
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00401580
21DROSHA_22980978_ChIP-Seq_HELA_Human1.99969445
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96908670
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96154433
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92695653
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91655994
26FUS_26573619_Chip-Seq_HEK293_Human1.87303966
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86128903
28* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85201962
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.84791717
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79549641
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79511613
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.79157766
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.72236569
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68534316
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68339476
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.64261596
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62877711
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61116722
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59394244
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57769912
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55793429
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55338049
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.53052344
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52594478
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47299101
46TAF15_26573619_Chip-Seq_HEK293_Human1.45341696
47EWS_26573619_Chip-Seq_HEK293_Human1.43754456
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.41731456
49TP53_16413492_ChIP-PET_HCT116_Human1.41597833
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40977507
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39674707
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39389753
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39206754
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37850341
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37802344
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37234983
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.34332242
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32666192
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32663963
60VDR_22108803_ChIP-Seq_LS180_Human1.32322070
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.31695983
62* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31276854
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30761592
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30545090
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.27733881
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25877382
67P300_19829295_ChIP-Seq_ESCs_Human1.25733663
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25700070
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25205974
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25114214
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25114214
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.24609192
73RNF2_27304074_Chip-Seq_NSC_Mouse1.24242847
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24089167
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.23544950
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.22912272
77ER_23166858_ChIP-Seq_MCF-7_Human1.22187417
78AR_19668381_ChIP-Seq_PC3_Human1.22120770
79* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20728969
80TP53_18474530_ChIP-ChIP_U2OS_Human1.20551146
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.20471922
82IGF1R_20145208_ChIP-Seq_DFB_Human1.19905805
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19893546
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.19474849
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18920885
86KDM2B_26808549_Chip-Seq_REH_Human1.18300598
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17501784
88BCAT_22108803_ChIP-Seq_LS180_Human1.17470204
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17220052
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16893603
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16876819
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.16602086
93SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16383783
94AHR_22903824_ChIP-Seq_MCF-7_Human1.16096175
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16052588
96CBP_20019798_ChIP-Seq_JUKART_Human1.15999359
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15999359
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15339250
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14987872
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14875530
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.14643609
102RXR_22108803_ChIP-Seq_LS180_Human1.14635915
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13947543
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13527535
105STAT3_23295773_ChIP-Seq_U87_Human1.13428309
106* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13162737
107SOX9_26525672_Chip-Seq_HEART_Mouse1.11577900
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10247016
109AR_25329375_ChIP-Seq_VCAP_Human1.09814115
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08354327
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06216085
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06198336
113ZNF274_21170338_ChIP-Seq_K562_Hela1.05525811
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.02813560
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02472558
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.02351743
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.02156438
118REST_21632747_ChIP-Seq_MESCs_Mouse1.02132288
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01914030
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.01116753
121KDM2B_26808549_Chip-Seq_K562_Human0.99541901
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97538567
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97273964
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97273964
125BRD4_25478319_ChIP-Seq_HGPS_Human0.97043495
126CJUN_26792858_Chip-Seq_BT549_Human0.96419560
127TCF4_23295773_ChIP-Seq_U87_Human0.96259325
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95994597
129* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94830676
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93342597
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92167711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.00304610
2MP0003122_maternal_imprinting2.79475890
3MP0005503_abnormal_tendon_morphology2.73150593
4MP0005623_abnormal_meninges_morphology2.69775822
5MP0008438_abnormal_cutaneous_collagen2.67344642
6MP0000751_myopathy2.62636797
7MP0003279_aneurysm2.59000655
8MP0000569_abnormal_digit_pigmentation2.44233115
9MP0004084_abnormal_cardiac_muscle2.36401495
10MP0001879_abnormal_lymphatic_vessel2.23079920
11MP0010368_abnormal_lymphatic_system2.08371906
12MP0004272_abnormal_basement_membrane1.96465027
13MP0004858_abnormal_nervous_system1.94542215
14MP0004215_abnormal_myocardial_fiber1.94039120
15MP0003635_abnormal_synaptic_transmissio1.89464514
16MP0009780_abnormal_chondrocyte_physiolo1.80582244
17MP0005646_abnormal_pituitary_gland1.70068439
18MP0001958_emphysema1.65262374
19MP0003787_abnormal_imprinting1.63543388
20MP0002108_abnormal_muscle_morphology1.62939258
21MP0000733_abnormal_muscle_development1.54955727
22MP0003091_abnormal_cell_migration1.54695099
23MP0000778_abnormal_nervous_system1.53134549
24MP0008775_abnormal_heart_ventricle1.52948806
25MP0003385_abnormal_body_wall1.52330167
26MP0003121_genomic_imprinting1.51974993
27MP0000767_abnormal_smooth_muscle1.50674590
28MP0009384_cardiac_valve_regurgitation1.50494543
29MP0003880_abnormal_central_pattern1.50407989
30MP0002063_abnormal_learning/memory/cond1.47060748
31MP0004885_abnormal_endolymph1.44764478
32MP0008789_abnormal_olfactory_epithelium1.41827276
33MP0006138_congestive_heart_failure1.41334416
34MP0003045_fibrosis1.40237591
35* MP0005595_abnormal_vascular_smooth1.38379744
36MP0006072_abnormal_retinal_apoptosis1.36342690
37MP0004036_abnormal_muscle_relaxation1.35931507
38MP0002837_dystrophic_cardiac_calcinosis1.35777112
39MP0001486_abnormal_startle_reflex1.35602606
40MP0005423_abnormal_somatic_nervous1.33195037
41MP0009745_abnormal_behavioral_response1.32388175
42MP0001299_abnormal_eye_distance/1.31400210
43MP0004145_abnormal_muscle_electrophysio1.30542242
44MP0003950_abnormal_plasma_membrane1.28768322
45MP0001984_abnormal_olfaction1.28745850
46MP0000534_abnormal_ureter_morphology1.27187780
47MP0003942_abnormal_urinary_system1.26739117
48MP0004087_abnormal_muscle_fiber1.26542666
49MP0001968_abnormal_touch/_nociception1.26156413
50MP0005167_abnormal_blood-brain_barrier1.25830472
51MP0004085_abnormal_heartbeat1.25780527
52MP0002972_abnormal_cardiac_muscle1.25405126
53MP0005620_abnormal_muscle_contractility1.24249105
54MP0004484_altered_response_of1.23644181
55MP0005670_abnormal_white_adipose1.22696637
56MP0003137_abnormal_impulse_conducting1.21505021
57MP0002272_abnormal_nervous_system1.21317621
58MP0001542_abnormal_bone_strength1.20817108
59MP0005275_abnormal_skin_tensile1.19594593
60MP0010630_abnormal_cardiac_muscle1.18381687
61MP0002249_abnormal_larynx_morphology1.16629239
62MP0002734_abnormal_mechanical_nocicepti1.14834710
63MP0005369_muscle_phenotype1.12817822
64MP0005551_abnormal_eye_electrophysiolog1.11733904
65MP0005253_abnormal_eye_physiology1.11529790
66MP0002572_abnormal_emotion/affect_behav1.11027898
67MP0002751_abnormal_autonomic_nervous1.10842795
68MP0004130_abnormal_muscle_cell1.10158047
69* MP0009250_abnormal_appendicular_skeleto1.10109403
70MP0008569_lethality_at_weaning1.08691934
71* MP0003755_abnormal_palate_morphology1.08217095
72MP0005645_abnormal_hypothalamus_physiol1.08158583
73MP0000749_muscle_degeneration1.06768176
74MP0002067_abnormal_sensory_capabilities1.06557795
75MP0003705_abnormal_hypodermis_morpholog1.06545149
76MP0001544_abnormal_cardiovascular_syste1.06147902
77MP0005385_cardiovascular_system_phenoty1.06147902
78MP0002064_seizures1.06023446
79MP0003828_pulmonary_edema1.03867141
80MP0004808_abnormal_hematopoietic_stem1.03810479
81MP0005508_abnormal_skeleton_morphology1.02884263
82MP0003115_abnormal_respiratory_system1.02551324
83MP0002106_abnormal_muscle_physiology1.01406872
84MP0000013_abnormal_adipose_tissue1.01315248
85MP0005394_taste/olfaction_phenotype0.99890315
86MP0005499_abnormal_olfactory_system0.99890315
87MP0001502_abnormal_circadian_rhythm0.98893580
88MP0005171_absent_coat_pigmentation0.98101868
89MP0002295_abnormal_pulmonary_circulatio0.97857209
90MP0000759_abnormal_skeletal_muscle0.96607242
91MP0005367_renal/urinary_system_phenotyp0.96466175
92MP0000516_abnormal_urinary_system0.96466175
93* MP0003935_abnormal_craniofacial_develop0.95651463
94MP0000428_abnormal_craniofacial_morphol0.95470480
95MP0002557_abnormal_social/conspecific_i0.94749578
96MP0005330_cardiomyopathy0.94564795
97MP0000049_abnormal_middle_ear0.94069307
98MP0002925_abnormal_cardiovascular_devel0.94007407
99MP0006276_abnormal_autonomic_nervous0.93934087
100MP0002009_preneoplasia0.93677064
101MP0000631_abnormal_neuroendocrine_gland0.93532249
102MP0004510_myositis0.92920010
103MP0004270_analgesia0.92679713
104MP0009053_abnormal_anal_canal0.92190643
105MP0005187_abnormal_penis_morphology0.92053748
106MP0002752_abnormal_somatic_nervous0.91432860
107MP0002184_abnormal_innervation0.91355552
108MP0001177_atelectasis0.91265426
109MP0004142_abnormal_muscle_tone0.91191897
110MP0000026_abnormal_inner_ear0.90961800
111MP0009278_abnormal_bone_marrow0.90914242
112* MP0002233_abnormal_nose_morphology0.90526363
113MP0002882_abnormal_neuron_morphology0.89102739
114MP0002127_abnormal_cardiovascular_syste0.89014598
115MP0002736_abnormal_nociception_after0.88473565
116MP0000955_abnormal_spinal_cord0.88048384
117* MP0002128_abnormal_blood_circulation0.87671456
118MP0002822_catalepsy0.87438262
119MP0006054_spinal_hemorrhage0.87014287
120MP0002735_abnormal_chemical_nociception0.86866274
121MP0003937_abnormal_limbs/digits/tail_de0.86321447
122MP0001270_distended_abdomen0.85971329
123MP0004811_abnormal_neuron_physiology0.85914044
124MP0002089_abnormal_postnatal_growth/wei0.85651005
125MP0002638_abnormal_pupillary_reflex0.84974604
126MP0000266_abnormal_heart_morphology0.83795254
127MP0010030_abnormal_orbit_morphology0.83556377
128MP0005195_abnormal_posterior_eye0.83288653
129MP0002234_abnormal_pharynx_morphology0.83222994
130MP0003646_muscle_fatigue0.82780011
131* MP0002116_abnormal_craniofacial_bone0.82207692
132MP0009046_muscle_twitch0.81705461
133MP0000750_abnormal_muscle_regeneration0.81704445
134MP0008961_abnormal_basal_metabolism0.81675131
135MP0004134_abnormal_chest_morphology0.81546037

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.60727387
2Broad metatarsal (HP:0001783)3.31434250
3Aortic aneurysm (HP:0004942)3.15896499
4Abnormality of the ischium (HP:0003174)2.97898871
5Atonic seizures (HP:0010819)2.88272952
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87040098
7Short 4th metacarpal (HP:0010044)2.87040098
8Shallow orbits (HP:0000586)2.85949070
9Hyperventilation (HP:0002883)2.84588280
10Cerebral aneurysm (HP:0004944)2.84083584
11Aortic dissection (HP:0002647)2.70706068
12Hypoplastic ischia (HP:0003175)2.66928119
13Abnormality of the 4th metacarpal (HP:0010012)2.65423512
14Neonatal short-limb short stature (HP:0008921)2.58691453
15Atrial fibrillation (HP:0005110)2.56923057
16Slender build (HP:0001533)2.54468455
17Arterial tortuosity (HP:0005116)2.52357552
18Bladder diverticulum (HP:0000015)2.50776137
19Primary atrial arrhythmia (HP:0001692)2.49302980
20Vascular tortuosity (HP:0004948)2.47918577
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43405347
22Increased corneal curvature (HP:0100692)2.42134288
23Keratoconus (HP:0000563)2.42134288
24Nemaline bodies (HP:0003798)2.41600643
25Muscle fiber inclusion bodies (HP:0100299)2.41068995
26Muscle hypertrophy of the lower extremities (HP:0008968)2.39930034
27Overgrowth (HP:0001548)2.35651348
28Supraventricular arrhythmia (HP:0005115)2.33055053
29Supraventricular tachycardia (HP:0004755)2.30343464
30Oligodactyly (hands) (HP:0001180)2.29664199
31Dilatation of the ascending aorta (HP:0005111)2.27963243
32Hip contracture (HP:0003273)2.26345689
33Febrile seizures (HP:0002373)2.26107080
34Prolonged QT interval (HP:0001657)2.25689904
35Sudden death (HP:0001699)2.22919097
36Hyperacusis (HP:0010780)2.22792590
37Macroorchidism (HP:0000053)2.21913971
38Type 1 muscle fiber predominance (HP:0003803)2.21291394
39Hemiparesis (HP:0001269)2.18893738
40Volvulus (HP:0002580)2.18531353
41Distal arthrogryposis (HP:0005684)2.17725607
42Renal duplication (HP:0000075)2.17641876
43Abnormality of the calf musculature (HP:0001430)2.17570042
44Narrow palate (HP:0000189)2.17441185
45Bowel diverticulosis (HP:0005222)2.16850747
46Enlarged penis (HP:0000040)2.16422807
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16178109
48Wide anterior fontanel (HP:0000260)2.15629765
49Increased variability in muscle fiber diameter (HP:0003557)2.13868555
50Premature rupture of membranes (HP:0001788)2.11761357
51Megalencephaly (HP:0001355)2.10766095
52Papilledema (HP:0001085)2.10613008
53Lower limb amyotrophy (HP:0007210)2.10387021
54Obsessive-compulsive behavior (HP:0000722)2.09996068
55Syringomyelia (HP:0003396)2.09461553
56Spinal cord lesions (HP:0100561)2.09461553
57Striae distensae (HP:0001065)2.09245081
58Mitral valve prolapse (HP:0001634)2.09033001
59Elfin facies (HP:0004428)2.08071831
60Ankle contracture (HP:0006466)2.07552228
61Infantile muscular hypotonia (HP:0008947)2.05654514
62Asymmetry of the thorax (HP:0001555)2.04709329
63Broad ribs (HP:0000885)2.02516048
64True hermaphroditism (HP:0010459)2.02180924
65Absent frontal sinuses (HP:0002688)2.01072381
66Action tremor (HP:0002345)1.98481953
67Aneurysm (HP:0002617)1.97625910
68Limb-girdle muscle weakness (HP:0003325)1.97523569
69Pulmonary artery stenosis (HP:0004415)1.96895342
70Progressive cerebellar ataxia (HP:0002073)1.96563341
71Absent phalangeal crease (HP:0006109)1.96130596
72Mild short stature (HP:0003502)1.94783966
73Flat cornea (HP:0007720)1.92357699
74Focal motor seizures (HP:0011153)1.92124928
75Renovascular hypertension (HP:0100817)1.90875545
76Abnormality of skeletal muscle fiber size (HP:0012084)1.90495111
77Atrophic scars (HP:0001075)1.90249871
78Increased connective tissue (HP:0009025)1.90176098
79Focal seizures (HP:0007359)1.90114614
80Drooling (HP:0002307)1.89424858
81Nephronophthisis (HP:0000090)1.89351836
82Abnormality of the left ventricular outflow tract (HP:0011103)1.88710397
83Subaortic stenosis (HP:0001682)1.88710397
84Calcaneovalgus deformity (HP:0001848)1.88585352
85Trigonocephaly (HP:0000243)1.87517510
86Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86957828
87Follicular hyperkeratosis (HP:0007502)1.86670046
88Chronic hepatic failure (HP:0100626)1.86338761
89Abnormality of the nasal septum (HP:0000419)1.85983568
90Fetal akinesia sequence (HP:0001989)1.85428494
91Hypoventilation (HP:0002791)1.84714125
92Hyporeflexia of lower limbs (HP:0002600)1.83220309
93Esophageal atresia (HP:0002032)1.82459881
94Pointed chin (HP:0000307)1.82396486
95Deformed tarsal bones (HP:0008119)1.81910545
96Difficulty running (HP:0009046)1.80902301
97Rectal prolapse (HP:0002035)1.80760215
98Aortic regurgitation (HP:0001659)1.79477071
99Hemiplegia (HP:0002301)1.78265171
100Vertebral arch anomaly (HP:0008438)1.78212901
101Gastrointestinal atresia (HP:0002589)1.76157529
102Hypoplasia of the iris (HP:0007676)1.75763621
103Hepatoblastoma (HP:0002884)1.75376190
104Tented upper lip vermilion (HP:0010804)1.75267719
105Pancreatic fibrosis (HP:0100732)1.74999965
106Adactyly (HP:0009776)1.74787833
107Exotropia (HP:0000577)1.74585077
108Abnormality of the renal medulla (HP:0100957)1.74462021
109Lymphangioma (HP:0100764)1.74071376
110Ulnar claw (HP:0001178)1.73341123
111Truncal obesity (HP:0001956)1.72964231
112Absent speech (HP:0001344)1.72804029
113Abnormality of dentin (HP:0010299)1.72670996
114Mitral regurgitation (HP:0001653)1.72570635
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.72476191
116Exercise-induced myalgia (HP:0003738)1.72390643
117Fibular hypoplasia (HP:0003038)1.72320639
118Hematochezia (HP:0002573)1.72290478
119Long eyelashes (HP:0000527)1.72116997
120Pulmonic stenosis (HP:0001642)1.71486988
121Round ear (HP:0100830)1.70761209
122Oligodactyly (HP:0012165)1.70403932
123Soft skin (HP:0000977)1.68770939
124Genetic anticipation (HP:0003743)1.67787537
125Joint laxity (HP:0001388)1.67502226
126Molar tooth sign on MRI (HP:0002419)1.66917501
127Abnormality of midbrain morphology (HP:0002418)1.66917501
128Midline defect of the nose (HP:0004122)1.66098398
129Excessive salivation (HP:0003781)1.65951002
130Tibial bowing (HP:0002982)1.65719839
131Delayed gross motor development (HP:0002194)1.65264332
132Distal lower limb amyotrophy (HP:0008944)1.65221566
133Cutaneous finger syndactyly (HP:0010554)1.64922871
134Mildly elevated creatine phosphokinase (HP:0008180)1.64560977
135Muscle fiber splitting (HP:0003555)1.64226271
136Subacute progressive viral hepatitis (HP:0006572)1.63928065
137Abnormal finger flexion creases (HP:0006143)1.63912196
138Genu recurvatum (HP:0002816)1.63466748
139Cystic hygroma (HP:0000476)1.62777595
140Hypoplastic nipples (HP:0002557)1.62467599
141Neoplasm of the heart (HP:0100544)1.62463448
142Chorioretinal atrophy (HP:0000533)1.61342055
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.61001419
144Spinal canal stenosis (HP:0003416)1.59920462
145Myotonia (HP:0002486)1.59748533
146Proximal amyotrophy (HP:0007126)1.58656161
147Long clavicles (HP:0000890)1.58466823
148Calf muscle hypertrophy (HP:0008981)1.57870942
149Spinal rigidity (HP:0003306)1.57053401
150Morphological abnormality of the middle ear (HP:0008609)1.56684858
151Increased nuchal translucency (HP:0010880)1.55746350
152Spondylolisthesis (HP:0003302)1.55137937
153Sacral dimple (HP:0000960)1.53606587
154Wrist flexion contracture (HP:0001239)1.53334968
155Deviation of the hallux (HP:0010051)1.53230118
156Venous insufficiency (HP:0005293)1.52600642
157Open mouth (HP:0000194)1.52459845
158Limited hip movement (HP:0008800)1.52230516
159Skull defect (HP:0001362)1.52201572
160Increased density of long bones (HP:0006392)1.51915303
161Narrow nasal bridge (HP:0000446)1.51473079
162Abnormality of the right ventricle (HP:0001707)1.50366856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK22.87446302
2DMPK2.53658491
3NTRK32.51949592
4PDGFRA2.48528469
5TRIB32.18403678
6CASK2.17656863
7FRK2.14153257
8NTRK22.06491473
9MAP4K22.03963781
10PNCK2.03059924
11MAP2K61.94935065
12PRKD31.84359275
13CAMK1G1.83918845
14EPHA41.82414066
15SIK11.82054842
16PHKG11.80466985
17PHKG21.80466985
18TTN1.75733573
19STK38L1.67291476
20FGFR31.65955947
21TIE11.60978618
22CCNB11.59015613
23CAMK1D1.56761723
24LMTK21.56486256
25KSR11.45803485
26STK391.45778930
27SGK21.42226198
28PRKCH1.41773220
29SGK31.41140157
30INSRR1.38103579
31PIK3CG1.38098699
32MAP3K41.37317997
33NEK91.34388428
34PKN11.33780313
35EPHB21.33383745
36MAPK131.26410059
37TNIK1.23556115
38PDGFRB1.20917392
39PAK61.20724300
40PAK31.16778511
41PTK2B1.16547199
42DDR21.14563693
43WNK31.13051028
44FER1.12508092
45MARK11.11432638
46BMPR1B1.10481914
47PIK3CA1.10378396
48RET1.10090026
49NEK11.09152840
50ROCK11.07830249
51NTRK11.06489340
52MAP3K51.05013909
53MINK11.02151352
54TGFBR21.01652192
55CAMKK11.00182491
56BCR0.99601293
57GRK10.97349553
58CDC42BPA0.97009487
59LATS10.96552479
60SIK20.95387203
61PINK10.94547680
62MAP3K70.94373798
63TYRO30.92934363
64ERBB30.92633589
65UHMK10.90891663
66PTK60.89860516
67MUSK0.89169513
68NUAK10.88600844
69CAMK40.88209308
70MKNK20.87301056
71OBSCN0.86884316
72FES0.86626176
73PKN20.83154263
74WNK10.82096465
75SGK4940.80642994
76SGK2230.80642994
77CSNK1G20.80494434
78JAK10.80402133
79RIPK10.80285034
80TLK10.79747546
81ERBB20.79537262
82CDK80.79369850
83PLK20.79100495
84FGFR10.78983987
85EPHA30.78774471
86NLK0.77599240
87PRPF4B0.77490980
88FGFR20.75931866
89STK240.75512088
90CDK50.74580110
91MAPK150.72072019
92ILK0.71856956
93PRKCG0.69958067
94ROCK20.69817362
95PRKD10.69768164
96CHUK0.69433098
97TGFBR10.68271854
98STK380.67847831
99PRKG10.67125499
100CAMK10.64774368
101MELK0.63532135
102IGF1R0.63436817
103BRD40.59820957
104NEK20.58870034
105CSNK1G10.58804653
106ADRBK20.58804025
107MAP2K70.57852535
108JAK30.57222991
109STK110.57081662
110SGK10.56592227
111MOS0.55045109
112DAPK20.54595596
113PAK20.54322156
114ERBB40.53736090
115RPS6KA30.53568063
116LIMK10.53220303
117AKT30.53196886
118MYLK0.53146650
119BMX0.52758709
120SIK30.52661258
121STK30.52555964
122PRKCE0.52345601
123DYRK1A0.52053114
124SRC0.51989810
125DYRK20.51914128
126PLK40.51399597
127RPS6KA20.50615601
128WNK40.50022234
129PRKAA20.49501187
130ADRBK10.49457424
131CSNK1A1L0.48966542
132CAMKK20.48051991
133PRKD20.47724230
134CDK30.47058593
135MAPK70.46650339
136DYRK1B0.45179193
137CAMK2A0.44546029
138* MAPK80.44127669
139CAMK2B0.42718026
140CDK60.42244761
141KDR0.41153755
142WEE10.40785079
143GRK50.40522070
144INSR0.40372608

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.08793587
2Phototransduction_Homo sapiens_hsa047441.85733623
3Circadian entrainment_Homo sapiens_hsa047131.79015834
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77037717
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74670645
6Olfactory transduction_Homo sapiens_hsa047401.60900273
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60069131
8Renin secretion_Homo sapiens_hsa049241.51511562
9Morphine addiction_Homo sapiens_hsa050321.50166790
10Nicotine addiction_Homo sapiens_hsa050331.49275144
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49069031
12Glutamatergic synapse_Homo sapiens_hsa047241.46732860
13Glioma_Homo sapiens_hsa052141.46658397
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46635484
15Cholinergic synapse_Homo sapiens_hsa047251.46268138
16Focal adhesion_Homo sapiens_hsa045101.44359987
17Dorso-ventral axis formation_Homo sapiens_hsa043201.42886520
18GABAergic synapse_Homo sapiens_hsa047271.41940356
19Oxytocin signaling pathway_Homo sapiens_hsa049211.40787496
20Long-term potentiation_Homo sapiens_hsa047201.39178724
21Gap junction_Homo sapiens_hsa045401.34292686
22Cocaine addiction_Homo sapiens_hsa050301.31372357
23Nitrogen metabolism_Homo sapiens_hsa009101.30648958
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29755261
25Dopaminergic synapse_Homo sapiens_hsa047281.28495332
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27946057
27Amphetamine addiction_Homo sapiens_hsa050311.27434236
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25069852
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24575522
30Adherens junction_Homo sapiens_hsa045201.24438598
31Gastric acid secretion_Homo sapiens_hsa049711.24311815
32Insulin secretion_Homo sapiens_hsa049111.23647602
33Axon guidance_Homo sapiens_hsa043601.22867846
34Calcium signaling pathway_Homo sapiens_hsa040201.22360083
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21990752
36Viral myocarditis_Homo sapiens_hsa054161.21235014
37Salivary secretion_Homo sapiens_hsa049701.21154771
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20916110
39cAMP signaling pathway_Homo sapiens_hsa040241.20041381
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19115147
41Endometrial cancer_Homo sapiens_hsa052131.13866514
42Proteoglycans in cancer_Homo sapiens_hsa052051.13433755
43Melanogenesis_Homo sapiens_hsa049161.13181070
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13147597
45ECM-receptor interaction_Homo sapiens_hsa045121.13106408
46Chronic myeloid leukemia_Homo sapiens_hsa052201.13104917
47GnRH signaling pathway_Homo sapiens_hsa049121.10758097
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08664488
49Colorectal cancer_Homo sapiens_hsa052101.08593078
50Estrogen signaling pathway_Homo sapiens_hsa049151.06593357
51Protein digestion and absorption_Homo sapiens_hsa049741.05720269
52Long-term depression_Homo sapiens_hsa047301.04791186
53Rap1 signaling pathway_Homo sapiens_hsa040151.04262966
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.02918234
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.00074334
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99582939
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99417990
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98890500
59Wnt signaling pathway_Homo sapiens_hsa043100.98777688
60ErbB signaling pathway_Homo sapiens_hsa040120.98756303
61Basal cell carcinoma_Homo sapiens_hsa052170.98001422
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96411665
63* MicroRNAs in cancer_Homo sapiens_hsa052060.95901639
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.95060321
65Non-small cell lung cancer_Homo sapiens_hsa052230.94857846
66Type II diabetes mellitus_Homo sapiens_hsa049300.94422418
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94100802
68Taste transduction_Homo sapiens_hsa047420.93404922
69MAPK signaling pathway_Homo sapiens_hsa040100.90734317
70Platelet activation_Homo sapiens_hsa046110.90410857
71Serotonergic synapse_Homo sapiens_hsa047260.88978226
72Butanoate metabolism_Homo sapiens_hsa006500.88673093
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88209836
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85454818
75Hippo signaling pathway_Homo sapiens_hsa043900.85312601
76Notch signaling pathway_Homo sapiens_hsa043300.84819503
77Small cell lung cancer_Homo sapiens_hsa052220.84569763
78Melanoma_Homo sapiens_hsa052180.84115334
79Pancreatic cancer_Homo sapiens_hsa052120.83914737
80Renal cell carcinoma_Homo sapiens_hsa052110.80932838
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79647097
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78359140
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77997662
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76611932
85Pathways in cancer_Homo sapiens_hsa052000.75149976
86Hedgehog signaling pathway_Homo sapiens_hsa043400.75067954
87Prolactin signaling pathway_Homo sapiens_hsa049170.73987852
88Ras signaling pathway_Homo sapiens_hsa040140.73657837
89mTOR signaling pathway_Homo sapiens_hsa041500.73363829
90Insulin signaling pathway_Homo sapiens_hsa049100.73078177
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72182557
92Cardiac muscle contraction_Homo sapiens_hsa042600.70446808
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70372095
94Prostate cancer_Homo sapiens_hsa052150.70242970
95FoxO signaling pathway_Homo sapiens_hsa040680.70165839
96Glucagon signaling pathway_Homo sapiens_hsa049220.69090234
97Choline metabolism in cancer_Homo sapiens_hsa052310.68234301
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67461613
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66835034
100Fanconi anemia pathway_Homo sapiens_hsa034600.66514176
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66068483
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65328921
103Amoebiasis_Homo sapiens_hsa051460.65156551
104HTLV-I infection_Homo sapiens_hsa051660.64976361
105Circadian rhythm_Homo sapiens_hsa047100.64832152
106TGF-beta signaling pathway_Homo sapiens_hsa043500.64785175
107Insulin resistance_Homo sapiens_hsa049310.63449240
108Tight junction_Homo sapiens_hsa045300.63446925
109Chemokine signaling pathway_Homo sapiens_hsa040620.61481067
110Fatty acid biosynthesis_Homo sapiens_hsa000610.61202054
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59366990
112Lysine degradation_Homo sapiens_hsa003100.53847757
113Propanoate metabolism_Homo sapiens_hsa006400.53814584
114Pancreatic secretion_Homo sapiens_hsa049720.52509223
115Oocyte meiosis_Homo sapiens_hsa041140.50945212
116Thyroid hormone synthesis_Homo sapiens_hsa049180.50713541
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50015225
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49862894
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48969970
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48371813
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46558173

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