ZEB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.57401579
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.57401579
3modulation by symbiont of host immune response (GO:0052553)4.57401579
4positive regulation by symbiont of host defense response (GO:0052509)4.57401579
5modulation by symbiont of host defense response (GO:0052031)4.57401579
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.57401579
7central nervous system myelination (GO:0022010)4.41674100
8axon ensheathment in central nervous system (GO:0032291)4.41674100
9cellular extravasation (GO:0045123)4.09015524
10neutrophil activation involved in immune response (GO:0002283)3.84715862
11positive regulation of mast cell activation (GO:0033005)3.59900847
12L-amino acid import (GO:0043092)3.58691357
13detection of molecule of bacterial origin (GO:0032490)3.53386102
14macrophage activation involved in immune response (GO:0002281)3.42663832
15microglial cell activation (GO:0001774)3.42183188
16positive regulation of mast cell activation involved in immune response (GO:0033008)3.37675726
17positive regulation of mast cell degranulation (GO:0043306)3.37675726
18neutrophil mediated immunity (GO:0002446)3.34330650
19axon ensheathment (GO:0008366)3.33694835
20ensheathment of neurons (GO:0007272)3.33694835
21myelination (GO:0042552)3.32824981
22positive regulation of cellular amide metabolic process (GO:0034250)3.30885282
23response to lipoprotein particle (GO:0055094)3.22344074
24cellular response to ethanol (GO:0071361)3.21930363
25negative regulation of interleukin-12 production (GO:0032695)3.19921821
26regulation of B cell receptor signaling pathway (GO:0050855)3.19328061
27germinal center formation (GO:0002467)3.14179817
28response to muramyl dipeptide (GO:0032495)3.13815840
29histone H3-K4 trimethylation (GO:0080182)3.06787185
30regulation of mast cell activation (GO:0033003)3.04270732
31negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.02290502
32negative regulation of neurotransmitter secretion (GO:0046929)3.00430162
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99830344
34response to host immune response (GO:0052572)2.99830344
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97876642
36negative regulation of cell killing (GO:0031342)2.97876642
37long-chain fatty acid biosynthetic process (GO:0042759)2.97410717
38negative regulation of interleukin-1 beta production (GO:0032691)2.97037114
39regulation of gamma-delta T cell activation (GO:0046643)2.94507559
40nerve growth factor signaling pathway (GO:0038180)2.87701300
41positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.82049468
42I-kappaB phosphorylation (GO:0007252)2.79930417
43regulation of interferon-beta biosynthetic process (GO:0045357)2.77755616
44positive regulation of heat generation (GO:0031652)2.77598405
45positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75769186
46negative regulation of neurotransmitter transport (GO:0051589)2.75150623
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74975443
48myeloid cell activation involved in immune response (GO:0002275)2.72999464
49positive regulation of granulocyte differentiation (GO:0030854)2.71760203
50regulation of inositol phosphate biosynthetic process (GO:0010919)2.70002481
51B cell receptor signaling pathway (GO:0050853)2.66258264
52Golgi to endosome transport (GO:0006895)2.65378369
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65115377
54response to host (GO:0075136)2.65115377
55response to host defenses (GO:0052200)2.65115377
56response to peptidoglycan (GO:0032494)2.64557833
57cell adhesion mediated by integrin (GO:0033627)2.63999794
58phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63743980
59Rap protein signal transduction (GO:0032486)2.62719910
60neutrophil activation (GO:0042119)2.61762268
61regulation of macrophage cytokine production (GO:0010935)2.60752042
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.60602484
63amino acid import (GO:0043090)2.59924991
64modulation by symbiont of host cellular process (GO:0044068)2.58780150
65cellular response to epinephrine stimulus (GO:0071872)2.57226819
66detection of external biotic stimulus (GO:0098581)2.56704614
67B cell homeostasis (GO:0001782)2.56530545
68regulation of heat generation (GO:0031650)2.55539346
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54104653
70positive regulation of B cell differentiation (GO:0045579)2.52949475
71import into cell (GO:0098657)2.48872068
72granulocyte activation (GO:0036230)2.48637645
73virion attachment to host cell (GO:0019062)2.48229393
74adhesion of symbiont to host cell (GO:0044650)2.48229393
75neural tube formation (GO:0001841)2.47911736
76positive T cell selection (GO:0043368)2.47218314
77regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47096084
78regulation of gamma-delta T cell differentiation (GO:0045586)2.47075665
79positive regulation of macrophage cytokine production (GO:0060907)2.46533811
80pyrimidine nucleobase catabolic process (GO:0006208)2.46438592
81detection of other organism (GO:0098543)2.46034231
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.45672149
83cerebral cortex radially oriented cell migration (GO:0021799)2.45398422
84myeloid leukocyte mediated immunity (GO:0002444)2.44640614
85oligodendrocyte differentiation (GO:0048709)2.43243378
86neuron remodeling (GO:0016322)2.41951012
87detection of biotic stimulus (GO:0009595)2.41501435
88semaphorin-plexin signaling pathway (GO:0071526)2.41461921
89negative regulation of interleukin-17 production (GO:0032700)2.39981287
90macrophage activation (GO:0042116)2.38458055
91cortical actin cytoskeleton organization (GO:0030866)2.38303020
92negative regulation of T cell mediated immunity (GO:0002710)2.37227951
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.36128396
94myelination in peripheral nervous system (GO:0022011)2.35599984
95peripheral nervous system axon ensheathment (GO:0032292)2.35599984
96leukocyte migration involved in inflammatory response (GO:0002523)2.34838634
97peptidyl-tyrosine autophosphorylation (GO:0038083)2.34830162
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34779883
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.34288355
100presynaptic membrane assembly (GO:0097105)2.34220884
101negative regulation of interleukin-1 production (GO:0032692)2.33960857
102regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.33948630
103synaptic vesicle endocytosis (GO:0048488)2.33748101
104heterotypic cell-cell adhesion (GO:0034113)2.32891472
105positive regulation of gamma-delta T cell activation (GO:0046645)2.32213636
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26923090
107presynaptic membrane organization (GO:0097090)2.25489888
108cortical cytoskeleton organization (GO:0030865)2.24581879
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24119654
110regulation of germinal center formation (GO:0002634)2.23912059
111cerebellar Purkinje cell differentiation (GO:0021702)2.23615517
112positive regulation of leukocyte degranulation (GO:0043302)2.20780235
113interferon-gamma production (GO:0032609)2.20639563
114activated T cell proliferation (GO:0050798)2.20230765
115regulation of fever generation (GO:0031620)2.19947007
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.19799118
117regulation of interleukin-17 production (GO:0032660)2.19769204
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18754670
119gamma-aminobutyric acid transport (GO:0015812)2.16681399
120response to nerve growth factor (GO:1990089)2.16251376
121cellular response to nerve growth factor stimulus (GO:1990090)2.16251376
122defense response to protozoan (GO:0042832)2.16238100
123neurotransmitter-gated ion channel clustering (GO:0072578)2.15980028
124mitochondrion distribution (GO:0048311)2.15915288
125regulation of leukocyte degranulation (GO:0043300)2.15665203
126positive regulation of interleukin-1 secretion (GO:0050716)2.14989783
127glycosylceramide metabolic process (GO:0006677)2.14924714
128regulation of Rap GTPase activity (GO:0032317)2.14735175
129neutrophil chemotaxis (GO:0030593)2.14358889
130positive regulation of toll-like receptor signaling pathway (GO:0034123)2.14233574
131astrocyte development (GO:0014002)2.13597905
132positive regulation of phosphatase activity (GO:0010922)2.13360000
133negative regulation of acute inflammatory response (GO:0002674)2.13153584
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.12974701
135regulation of platelet aggregation (GO:0090330)2.12754314
136cyclic nucleotide catabolic process (GO:0009214)2.12531318
137dendrite morphogenesis (GO:0048813)2.12315854
138natural killer cell mediated cytotoxicity (GO:0042267)2.11709609
139natural killer cell mediated immunity (GO:0002228)2.11709609
140phosphatidylinositol 3-kinase signaling (GO:0014065)2.11108303
141phospholipid translocation (GO:0045332)2.11008926
142lipid translocation (GO:0034204)2.11008926
143G-protein coupled receptor internalization (GO:0002031)2.10476871
144regulation of mast cell degranulation (GO:0043304)2.10077347
145regulation of MHC class II biosynthetic process (GO:0045346)2.09708038
146negative regulation of lymphocyte mediated immunity (GO:0002707)2.09409991
147phagocytosis, recognition (GO:0006910)2.09267627
148neutrophil migration (GO:1990266)2.08784526
149central nervous system projection neuron axonogenesis (GO:0021952)2.08477080
150respiratory burst (GO:0045730)2.07522626
151clathrin coat assembly (GO:0048268)2.04091303
152regulation of mast cell activation involved in immune response (GO:0033006)2.02140049
153glutamate receptor signaling pathway (GO:0007215)2.01156276
154regulation of collateral sprouting (GO:0048670)1.99625122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.26645123
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.02613158
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.62976455
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.61132286
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46773499
6* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31532637
7GATA1_22025678_ChIP-Seq_K562_Human2.30629969
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25085241
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12458771
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.07975627
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.06884340
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04824202
13EZH2_22144423_ChIP-Seq_EOC_Human1.92517838
14* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84765854
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83225217
16* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77740287
17TP53_16413492_ChIP-PET_HCT116_Human1.71822652
18AR_21572438_ChIP-Seq_LNCaP_Human1.68616480
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68352686
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66071775
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65838636
22* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63315178
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59744715
24DROSHA_22980978_ChIP-Seq_HELA_Human1.59695506
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59628403
26* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58494139
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58477474
28* VDR_24787735_ChIP-Seq_THP-1_Human1.56998138
29ER_23166858_ChIP-Seq_MCF-7_Human1.56504083
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55943468
31TAF15_26573619_Chip-Seq_HEK293_Human1.52596183
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52363036
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.52231177
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51673150
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51527956
36* P300_19829295_ChIP-Seq_ESCs_Human1.50814634
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49745688
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.49060083
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.46062745
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44720244
41* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43648476
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43413943
43SMAD4_21799915_ChIP-Seq_A2780_Human1.41479381
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41100843
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41100843
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40856741
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.38826382
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.38004434
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37241087
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37241087
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36629006
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36549375
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.35559432
54AHR_22903824_ChIP-Seq_MCF-7_Human1.35250898
55* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33648924
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33282304
57IGF1R_20145208_ChIP-Seq_DFB_Human1.32569963
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32512224
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32324193
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31789323
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31685118
62SPI1_23127762_ChIP-Seq_K562_Human1.27794936
63* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27601189
64* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27601189
65STAT3_23295773_ChIP-Seq_U87_Human1.26683814
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26676040
67RUNX_20019798_ChIP-Seq_JUKART_Human1.25600964
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25264530
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24241364
70* FUS_26573619_Chip-Seq_HEK293_Human1.24088150
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.23746905
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21798814
73* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21136924
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.20790659
75* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20720673
76* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20627792
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19339587
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19291122
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19182915
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16023606
81* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15158542
82TP53_18474530_ChIP-ChIP_U2OS_Human1.14796608
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.13443456
84* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12606646
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12117657
86* TCF4_23295773_ChIP-Seq_U87_Human1.11895262
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11078099
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10944313
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.09665748
90REST_21632747_ChIP-Seq_MESCs_Mouse1.08199106
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.08083423
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.08079613
93VDR_22108803_ChIP-Seq_LS180_Human1.08002423
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06551997
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05769938
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.05729245
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05590833
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.05443713
99KDM2B_26808549_Chip-Seq_REH_Human1.04883618
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04606529
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04423126
102RXR_22108803_ChIP-Seq_LS180_Human1.04124603
103* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02996663
104* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02619101
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02091593
106AR_25329375_ChIP-Seq_VCAP_Human1.01956052
107RUNX2_22187159_ChIP-Seq_PCA_Human1.01478812
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01446942
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01383965
110CBP_20019798_ChIP-Seq_JUKART_Human1.00514963
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00514963
112* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00175738
113BCAT_22108803_ChIP-Seq_LS180_Human0.99449410
114* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99162981
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99053767
116SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98894420
117* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97953669
118* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97900225
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.97846595
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97682936
121* SCL_19346495_ChIP-Seq_HPC-7_Human0.96709264
122* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96424638
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96380378
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.96237827
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.96058393
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95579028
127* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95107168
128* P53_22387025_ChIP-Seq_ESCs_Mouse0.94055300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.96883545
2MP0000920_abnormal_myelination3.44873721
3MP0003172_abnormal_lysosome_physiology2.92841956
4MP0005058_abnormal_lysosome_morphology2.73090692
5MP0005174_abnormal_tail_pigmentation2.64903070
6MP0005171_absent_coat_pigmentation2.64453827
7MP0003690_abnormal_glial_cell2.64157985
8MP0004859_abnormal_synaptic_plasticity2.47656008
9MP0000015_abnormal_ear_pigmentation2.33834929
10MP0005409_darkened_coat_color2.33595666
11MP0003880_abnormal_central_pattern2.26618100
12MP0004510_myositis2.15221915
13MP0003303_peritoneal_inflammation2.01760505
14MP0002419_abnormal_innate_immunity1.96633343
15MP0003634_abnormal_glial_cell1.80648294
16MP0003136_yellow_coat_color1.80628081
17MP0000604_amyloidosis1.79780344
18MP0004270_analgesia1.74486512
19MP0009278_abnormal_bone_marrow1.72417774
20MP0003950_abnormal_plasma_membrane1.72154346
21MP0004381_abnormal_hair_follicle1.71992531
22MP0003787_abnormal_imprinting1.71676892
23MP0003183_abnormal_peptide_metabolism1.65775815
24MP0004742_abnormal_vestibular_system1.62986812
25MP0008438_abnormal_cutaneous_collagen1.62686749
26MP0009046_muscle_twitch1.61193708
27MP0001545_abnormal_hematopoietic_system1.61032387
28MP0005397_hematopoietic_system_phenotyp1.61032387
29MP0000465_gastrointestinal_hemorrhage1.60498846
30MP0004883_abnormal_blood_vessel1.56112237
31MP0004130_abnormal_muscle_cell1.56012257
32MP0001986_abnormal_taste_sensitivity1.54510640
33MP0002735_abnormal_chemical_nociception1.53881047
34MP0006082_CNS_inflammation1.53000316
35MP0005167_abnormal_blood-brain_barrier1.52913960
36MP0000383_abnormal_hair_follicle1.51652865
37MP0000778_abnormal_nervous_system1.50671716
38MP0001835_abnormal_antigen_presentation1.49686944
39MP0009764_decreased_sensitivity_to1.47736837
40MP0006054_spinal_hemorrhage1.46689240
41MP0001486_abnormal_startle_reflex1.44957698
42MP0003656_abnormal_erythrocyte_physiolo1.44659711
43MP0005000_abnormal_immune_tolerance1.44226699
44MP0002064_seizures1.44061690
45MP0001790_abnormal_immune_system1.42863803
46MP0005387_immune_system_phenotype1.42863803
47MP0001851_eye_inflammation1.42410497
48MP0005257_abnormal_intraocular_pressure1.39698242
49MP0008260_abnormal_autophagy1.38245177
50MP0003632_abnormal_nervous_system1.38072554
51MP0001958_emphysema1.33426800
52MP0003045_fibrosis1.33066915
53MP0002998_abnormal_bone_remodeling1.29309328
54MP0002452_abnormal_antigen_presenting1.29143351
55MP0004134_abnormal_chest_morphology1.25199466
56MP0002723_abnormal_immune_serum1.23621237
57MP0002148_abnormal_hypersensitivity_rea1.23052067
58MP0003635_abnormal_synaptic_transmissio1.21923665
59MP0010678_abnormal_skin_adnexa1.21088005
60MP0005075_abnormal_melanosome_morpholog1.20752354
61MP0002332_abnormal_exercise_endurance1.19613064
62MP0008004_abnormal_stomach_pH1.17415161
63MP0001299_abnormal_eye_distance/1.17229673
64MP0005025_abnormal_response_to1.16465529
65MP0001968_abnormal_touch/_nociception1.15388334
66MP0001800_abnormal_humoral_immune1.15241175
67MP0003724_increased_susceptibility_to1.12537211
68MP0004484_altered_response_of1.12525921
69MP0003436_decreased_susceptibility_to1.10850473
70MP0005464_abnormal_platelet_physiology1.10669549
71MP0009745_abnormal_behavioral_response1.10598639
72MP0002405_respiratory_system_inflammati1.09939896
73MP0001440_abnormal_grooming_behavior1.08390137
74MP0003631_nervous_system_phenotype1.07243976
75MP0003329_amyloid_beta_deposits1.06516717
76MP0002272_abnormal_nervous_system1.06236570
77MP0000716_abnormal_immune_system1.05252549
78MP0003091_abnormal_cell_migration1.04430371
79MP0000343_altered_response_to1.01460807
80MP0000371_diluted_coat_color1.01443362
81MP0001533_abnormal_skeleton_physiology1.01213200
82MP0008057_abnormal_DNA_replication1.00947843
83MP0003075_altered_response_to0.99419834
84MP0001819_abnormal_immune_cell0.98588005
85MP0002420_abnormal_adaptive_immunity0.97795995
86MP0002398_abnormal_bone_marrow0.97539857
87MP0003448_altered_tumor_morphology0.97061800
88MP0003633_abnormal_nervous_system0.96815783
89MP0001501_abnormal_sleep_pattern0.95056031
90MP0002063_abnormal_learning/memory/cond0.94840806
91MP0002572_abnormal_emotion/affect_behav0.93786033
92MP0002733_abnormal_thermal_nociception0.93459297
93MP0001845_abnormal_inflammatory_respons0.91614393
94MP0001970_abnormal_pain_threshold0.90273153
95MP0003763_abnormal_thymus_physiology0.88815965
96MP0000733_abnormal_muscle_development0.86639327
97MP0003828_pulmonary_edema0.85484540
98MP0005310_abnormal_salivary_gland0.81900105
99MP0002009_preneoplasia0.81655338
100MP0002067_abnormal_sensory_capabilities0.81454149
101MP0005388_respiratory_system_phenotype0.81313369
102MP0002133_abnormal_respiratory_system0.81313369
103MP0005386_behavior/neurological_phenoty0.81186178
104MP0004924_abnormal_behavior0.81186178
105MP0000689_abnormal_spleen_morphology0.81058848
106MP0002095_abnormal_skin_pigmentation0.80903697
107MP0002166_altered_tumor_susceptibility0.80342840
108MP0004947_skin_inflammation0.79609523
109MP0004885_abnormal_endolymph0.79507678
110MP0004808_abnormal_hematopoietic_stem0.79406952
111MP0000249_abnormal_blood_vessel0.79194033
112MP0002938_white_spotting0.78539692
113MP0000685_abnormal_immune_system0.78133094
114MP0001661_extended_life_span0.77690203
115MP0005595_abnormal_vascular_smooth0.77079286
116MP0004084_abnormal_cardiac_muscle0.76988527
117MP0009785_altered_susceptibility_to0.75951066
118MP0002229_neurodegeneration0.75186322
119MP0002075_abnormal_coat/hair_pigmentati0.74244094
120MP0003938_abnormal_ear_development0.72756838
121MP0002006_tumorigenesis0.70829542
122MP0002295_abnormal_pulmonary_circulatio0.70785578
123MP0003300_gastrointestinal_ulcer0.70600546
124MP0002882_abnormal_neuron_morphology0.70283090
125MP0000955_abnormal_spinal_cord0.69072060
126MP0005671_abnormal_response_to0.68272699
127MP0005164_abnormal_response_to0.65588704
128MP0005408_hypopigmentation0.64943591
129MP0002168_other_aberrant_phenotype0.64756772
130MP0004185_abnormal_adipocyte_glucose0.62967246
131MP0000767_abnormal_smooth_muscle0.62304884
132MP0004142_abnormal_muscle_tone0.61516710
133MP0004858_abnormal_nervous_system0.60870057
134MP0000427_abnormal_hair_cycle0.59727302

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.63251798
2Recurrent abscess formation (HP:0002722)4.41055902
3Recurrent bacterial skin infections (HP:0005406)4.29667813
4Neurofibrillary tangles (HP:0002185)3.77048857
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.66333764
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.66333764
7Stomatitis (HP:0010280)3.59785601
8Thick nail (HP:0001805)3.35314138
9Onion bulb formation (HP:0003383)3.23205448
10Supranuclear gaze palsy (HP:0000605)3.21436563
11Slow saccadic eye movements (HP:0000514)3.14474470
12Spontaneous hematomas (HP:0007420)3.10719516
13Prostate neoplasm (HP:0100787)3.10637712
14Recurrent cutaneous fungal infections (HP:0011370)3.08086169
15Chronic mucocutaneous candidiasis (HP:0002728)3.08086169
16Febrile seizures (HP:0002373)3.00207466
17Recurrent fungal infections (HP:0002841)2.99479735
18White forelock (HP:0002211)2.97463379
19Abnormality of macrophages (HP:0004311)2.90049388
20Cerebral inclusion bodies (HP:0100314)2.88964033
21Myositis (HP:0100614)2.86398045
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.84461631
23Orchitis (HP:0100796)2.81505143
24Increased cerebral lipofuscin (HP:0011813)2.80907768
25Amyloidosis (HP:0011034)2.80145918
26Abnormality of the corticospinal tract (HP:0002492)2.75720023
27Recurrent skin infections (HP:0001581)2.69642797
28Patchy hypopigmentation of hair (HP:0011365)2.67492825
29T lymphocytopenia (HP:0005403)2.65008921
30Eczematoid dermatitis (HP:0000976)2.64915964
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.64763209
32Hemiplegia (HP:0002301)2.64713175
33Axonal loss (HP:0003447)2.64608464
34Prolonged bleeding time (HP:0003010)2.57403463
35Gingivitis (HP:0000230)2.56790133
36Abnormality of T cell number (HP:0011839)2.55924748
37Elevated erythrocyte sedimentation rate (HP:0003565)2.55199636
38Progressive cerebellar ataxia (HP:0002073)2.50537070
39Alacrima (HP:0000522)2.50019005
40Peripheral hypomyelination (HP:0007182)2.47333157
41Absent frontal sinuses (HP:0002688)2.46145705
42Segmental peripheral demyelination/remyelination (HP:0003481)2.45389668
43Midline defect of the nose (HP:0004122)2.43631078
44Parakeratosis (HP:0001036)2.43225582
45Hemoptysis (HP:0002105)2.42604711
46* Absent speech (HP:0001344)2.41690902
47Postural instability (HP:0002172)2.41202321
48Gingival bleeding (HP:0000225)2.39790373
49Anteriorly placed anus (HP:0001545)2.39580785
50Peripheral demyelination (HP:0011096)2.38631075
51Decreased lacrimation (HP:0000633)2.37109882
52Amyotrophic lateral sclerosis (HP:0007354)2.35677348
53Chest pain (HP:0100749)2.35160624
54Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35120993
55Mutism (HP:0002300)2.34259466
56Disinhibition (HP:0000734)2.32520202
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.30730144
58Sensory axonal neuropathy (HP:0003390)2.29489524
59Abnormality of the periventricular white matter (HP:0002518)2.29161357
60Focal seizures (HP:0007359)2.28394783
61Scanning speech (HP:0002168)2.28051095
62Gaze-evoked nystagmus (HP:0000640)2.27780836
63Turricephaly (HP:0000262)2.26076494
64Aqueductal stenosis (HP:0002410)2.26018713
65Papillary thyroid carcinoma (HP:0002895)2.24727874
66Hypoplasia of the iris (HP:0007676)2.24632613
67Keratoconjunctivitis sicca (HP:0001097)2.23639129
68Mediastinal lymphadenopathy (HP:0100721)2.21709762
69Abnormality of the nasal septum (HP:0000419)2.20304999
70Keratoconjunctivitis (HP:0001096)2.19588073
71Abnormality of glycolipid metabolism (HP:0010969)2.19238673
72Abnormality of liposaccharide metabolism (HP:0010968)2.19238673
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.19238673
74Papilledema (HP:0001085)2.19174899
75Pulmonary infiltrates (HP:0002113)2.16005340
76Insidious onset (HP:0003587)2.16004460
77Termporal pattern (HP:0011008)2.16004460
78Broad-based gait (HP:0002136)2.15699472
79Abnormal auditory evoked potentials (HP:0006958)2.15685697
80Dysmetria (HP:0001310)2.15586470
81Periodontitis (HP:0000704)2.15539454
82Epistaxis (HP:0000421)2.14806234
83Action tremor (HP:0002345)2.14522950
84Conjunctival telangiectasia (HP:0000524)2.14171776
85Gastrointestinal infarctions (HP:0005244)2.11910692
86Atonic seizures (HP:0010819)2.10454639
87Clumsiness (HP:0002312)2.09574055
88Epileptic encephalopathy (HP:0200134)2.07339528
89Autoimmune thrombocytopenia (HP:0001973)2.06824472
90Encephalitis (HP:0002383)2.05689302
91Recurrent gram-negative bacterial infections (HP:0005420)2.05680069
92Generalized hypopigmentation of hair (HP:0011358)2.05535752
93Optic neuritis (HP:0100653)2.03197693
94Retrobulbar optic neuritis (HP:0100654)2.03197693
95Vacuolated lymphocytes (HP:0001922)2.02488989
96Recurrent viral infections (HP:0004429)2.01180025
97Depressed nasal tip (HP:0000437)2.00972315
98Pulmonary embolism (HP:0002204)1.98317536
99Inappropriate behavior (HP:0000719)1.97059486
100Akinesia (HP:0002304)1.96861209
101Eosinophilia (HP:0001880)1.95820086
102Tented upper lip vermilion (HP:0010804)1.94849118
103Abnormality of the frontal sinuses (HP:0002687)1.94653286
104Meningitis (HP:0001287)1.94203729
105Arterial thrombosis (HP:0004420)1.94115218
106Ankle clonus (HP:0011448)1.94002578
107Neuronal loss in central nervous system (HP:0002529)1.91888872
108Mixed hearing impairment (HP:0000410)1.91452996
109Narrow palate (HP:0000189)1.91292481
110Fair hair (HP:0002286)1.90791893
111Hematochezia (HP:0002573)1.90306685
112Thyroiditis (HP:0100646)1.90231845
113Thickened helices (HP:0000391)1.89989111
114Protruding tongue (HP:0010808)1.89444093
115Urethral obstruction (HP:0000796)1.89350690
116Abnormality of incisor morphology (HP:0011063)1.89132028
117Blue irides (HP:0000635)1.88799687
118* Excessive salivation (HP:0003781)1.88695159
119Bell-shaped thorax (HP:0001591)1.88067010
120Abnormality of primary teeth (HP:0006481)1.87885388
121Lower limb amyotrophy (HP:0007210)1.87806180
122* Drooling (HP:0002307)1.87075889
123Macroorchidism (HP:0000053)1.86757781
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86731299
125Decreased motor nerve conduction velocity (HP:0003431)1.85769222
126Chronic obstructive pulmonary disease (HP:0006510)1.85240694
127Obstructive lung disease (HP:0006536)1.85240694
128Abnormality of the sella turcica (HP:0002679)1.85048192
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.84832413
130Osteolytic defects of the hand bones (HP:0009699)1.84832413
131Distal lower limb amyotrophy (HP:0008944)1.83914933
132* Widely spaced teeth (HP:0000687)1.83232482
133Stomach cancer (HP:0012126)1.83025681
134Vertigo (HP:0002321)1.81752175
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81243509
136Lower limb muscle weakness (HP:0007340)1.80631287
137Diplopia (HP:0000651)1.79187111
138Abnormality of binocular vision (HP:0011514)1.79187111
139Spondylolisthesis (HP:0003302)1.78321975
140Premature skin wrinkling (HP:0100678)1.77549105
141Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77166311
142Arterial tortuosity (HP:0005116)1.76824424
143Panhypogammaglobulinemia (HP:0003139)1.76002471
144Neoplasm of the tracheobronchial system (HP:0100552)1.75790470
145Urinary bladder sphincter dysfunction (HP:0002839)1.75638409
146Leukocytosis (HP:0001974)1.75204761
147Poor eye contact (HP:0000817)1.73730876
148Intellectual disability, severe (HP:0010864)1.72269848
149Spastic gait (HP:0002064)1.72234308
150Ulnar claw (HP:0001178)1.70682829
151Premature loss of primary teeth (HP:0006323)1.69496170
152Ocular albinism (HP:0001107)1.69149450
153Intention tremor (HP:0002080)1.68881180
154Infantile muscular hypotonia (HP:0008947)1.66287947
155Plagiocephaly (HP:0001357)1.65886555
156Deformed sella turcica (HP:0002681)1.64223246
157Focal motor seizures (HP:0011153)1.64136927
158Genetic anticipation (HP:0003743)1.63888285
159J-shaped sella turcica (HP:0002680)1.61454057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.06025715
2FRK2.92199901
3CAMK1G2.64820989
4MAP3K132.49605268
5STK392.46912492
6EPHB12.38538481
7MAP3K142.33686438
8FGR2.20240413
9PKN12.08757511
10CAMK1D2.03613471
11IRAK41.88998999
12SIK21.86821444
13EPHA31.80735157
14FES1.79990264
15OXSR11.75811956
16EPHA41.65798866
17MAPK131.62896726
18PIK3CG1.61037894
19TNIK1.58282657
20KIT1.56080489
21PNCK1.54766446
22TEC1.50552704
23FGFR21.49898774
24CLK11.49040872
25CCNB11.48711069
26BLK1.45708508
27WNK11.41937118
28PLK21.39910086
29TAOK31.36436224
30CAMKK21.33223469
31IKBKE1.32648914
32DMPK1.32005683
33CSF1R1.23771576
34PRPF4B1.22401700
35CASK1.22253912
36BTK1.21837603
37PBK1.21583811
38MAP3K61.20756687
39ACVR1B1.19276979
40DAPK21.15606627
41BMPR21.15107189
42PTK2B1.13268742
43MARK21.11718605
44GRK71.11678647
45AKT31.11265253
46PDGFRB1.09603201
47IRAK31.09165632
48MET1.07262923
49JAK21.06901211
50JAK11.06617100
51NTRK21.05561988
52ZAP701.04379132
53MAPKAPK51.04031736
54SGK2231.00416902
55SGK4941.00416902
56NTRK10.98858744
57HCK0.98207633
58ICK0.97498816
59IKBKB0.96904813
60TBK10.96186370
61TYK20.95834903
62PINK10.95116320
63MATK0.94978714
64FYN0.94632712
65PRKCQ0.94275232
66IRAK20.93945441
67NTRK30.93368299
68SGK10.91147711
69CSNK1A1L0.90128118
70MAP2K40.87386727
71PAK60.84922341
72CSK0.84503913
73NEK60.83438555
74LCK0.81326763
75MAP2K70.81260234
76MAP4K10.80982887
77UHMK10.80632053
78TTN0.80513401
79INSRR0.79628893
80CDK50.79363475
81CAMK40.79179557
82PRKCE0.77335822
83CAMK2B0.77212077
84STK110.75924426
85GRK60.73352401
86MAP2K30.72994675
87BRD40.72917417
88KSR10.72092467
89YES10.71013097
90DYRK1A0.69830004
91PIK3CA0.68353227
92PDPK10.67633258
93ITK0.67518499
94MAPK70.67239462
95CDK120.66652436
96NUAK10.66325011
97MAPK100.66186408
98MARK10.65771990
99TGFBR20.65759007
100LYN0.62855293
101WNK30.62319433
102TXK0.62117211
103CAMK2D0.61972214
104CDK60.61090181
105IRAK10.60308518
106EGFR0.58668785
107MAPK40.57872790
108SYK0.57280087
109ERBB20.57147169
110MAP3K20.56452701
111DDR20.56067011
112ADRBK20.55184654
113TNK20.55179855
114SGK30.54849779
115ABL10.53715713
116SGK20.53067438
117GRK50.52592334
118GSK3A0.51977576
119ROCK20.51894663
120EIF2AK20.51707008
121BCR0.51507345
122PRKG10.50613030
123INSR0.50517073
124MARK30.50154822
125PRKD10.50045452
126TRPM70.49100521
127CAMKK10.48807773
128CAMK2A0.47092590
129CHUK0.47046848
130JAK30.46097004
131PAK30.45945312
132CDC42BPA0.45548438
133CAMK10.45537784
134BMX0.45326562
135SRC0.44516175
136MAP3K40.43995955
137PDK10.43544116
138BMPR1B0.41200462
139MAPK120.40851132

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043801.81757355
2NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71073961
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68231651
4B cell receptor signaling pathway_Homo sapiens_hsa046621.67929464
5Malaria_Homo sapiens_hsa051441.57464061
6Leishmaniasis_Homo sapiens_hsa051401.55443257
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51442852
8Rheumatoid arthritis_Homo sapiens_hsa053231.46396273
9Tuberculosis_Homo sapiens_hsa051521.43344185
10Pertussis_Homo sapiens_hsa051331.41636886
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.37016922
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36804079
13Axon guidance_Homo sapiens_hsa043601.35021548
14Staphylococcus aureus infection_Homo sapiens_hsa051501.34092367
15African trypanosomiasis_Homo sapiens_hsa051431.33757688
16Phagosome_Homo sapiens_hsa041451.30951405
17Lysosome_Homo sapiens_hsa041421.28410937
18Type II diabetes mellitus_Homo sapiens_hsa049301.24429267
19Glutamatergic synapse_Homo sapiens_hsa047241.23537132
20Chemokine signaling pathway_Homo sapiens_hsa040621.20076072
21Morphine addiction_Homo sapiens_hsa050321.18551267
22Nicotine addiction_Homo sapiens_hsa050331.18196663
23Ether lipid metabolism_Homo sapiens_hsa005651.16016336
24Sphingolipid signaling pathway_Homo sapiens_hsa040711.14992372
25Autoimmune thyroid disease_Homo sapiens_hsa053201.12897115
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12325298
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10531804
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09916666
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08314742
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.05547000
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04690576
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.04689727
33TNF signaling pathway_Homo sapiens_hsa046681.03730651
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.02531814
35Dorso-ventral axis formation_Homo sapiens_hsa043201.02243430
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02027356
37Type I diabetes mellitus_Homo sapiens_hsa049401.01743738
38Renin secretion_Homo sapiens_hsa049241.00786727
39Long-term depression_Homo sapiens_hsa047301.00784883
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00519233
41Collecting duct acid secretion_Homo sapiens_hsa049661.00492188
42Salmonella infection_Homo sapiens_hsa051321.00423591
43Steroid biosynthesis_Homo sapiens_hsa001000.99210297
44Renal cell carcinoma_Homo sapiens_hsa052110.98572059
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97971415
46Sphingolipid metabolism_Homo sapiens_hsa006000.97391665
47Circadian entrainment_Homo sapiens_hsa047130.96636825
48Graft-versus-host disease_Homo sapiens_hsa053320.96494404
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95968544
50Salivary secretion_Homo sapiens_hsa049700.95613655
51Asthma_Homo sapiens_hsa053100.95240412
52T cell receptor signaling pathway_Homo sapiens_hsa046600.94745159
53Toxoplasmosis_Homo sapiens_hsa051450.93941892
54ErbB signaling pathway_Homo sapiens_hsa040120.91744057
55Measles_Homo sapiens_hsa051620.90823994
56Legionellosis_Homo sapiens_hsa051340.89667085
57Shigellosis_Homo sapiens_hsa051310.89235165
58Prolactin signaling pathway_Homo sapiens_hsa049170.89203539
59Serotonergic synapse_Homo sapiens_hsa047260.88981006
60Glioma_Homo sapiens_hsa052140.88736377
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88623896
62Choline metabolism in cancer_Homo sapiens_hsa052310.87945095
63Acute myeloid leukemia_Homo sapiens_hsa052210.87914735
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87720854
65Cholinergic synapse_Homo sapiens_hsa047250.85456294
66Non-small cell lung cancer_Homo sapiens_hsa052230.83571074
67Ras signaling pathway_Homo sapiens_hsa040140.82858915
68cAMP signaling pathway_Homo sapiens_hsa040240.82715915
69Allograft rejection_Homo sapiens_hsa053300.82485590
70Long-term potentiation_Homo sapiens_hsa047200.82193271
71Platelet activation_Homo sapiens_hsa046110.81811335
72Amoebiasis_Homo sapiens_hsa051460.81530865
73GABAergic synapse_Homo sapiens_hsa047270.80589054
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80553911
75ECM-receptor interaction_Homo sapiens_hsa045120.80438678
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80299244
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79587668
78Hematopoietic cell lineage_Homo sapiens_hsa046400.79565537
79Pancreatic cancer_Homo sapiens_hsa052120.79524643
80Influenza A_Homo sapiens_hsa051640.79174839
81Endocytosis_Homo sapiens_hsa041440.79115463
82mTOR signaling pathway_Homo sapiens_hsa041500.79106842
83Calcium signaling pathway_Homo sapiens_hsa040200.78418866
84FoxO signaling pathway_Homo sapiens_hsa040680.76717265
85MAPK signaling pathway_Homo sapiens_hsa040100.76379766
86Estrogen signaling pathway_Homo sapiens_hsa049150.75168022
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74444955
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74135227
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.73837168
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73797797
91Chronic myeloid leukemia_Homo sapiens_hsa052200.73578472
92Hepatitis C_Homo sapiens_hsa051600.73500937
93Oxytocin signaling pathway_Homo sapiens_hsa049210.73065673
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.72792140
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72559869
96Amphetamine addiction_Homo sapiens_hsa050310.72326661
97Viral myocarditis_Homo sapiens_hsa054160.72112056
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71674153
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68236864
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67177788
101Taste transduction_Homo sapiens_hsa047420.67065249
102Focal adhesion_Homo sapiens_hsa045100.67006102
103Gap junction_Homo sapiens_hsa045400.66892305
104Gastric acid secretion_Homo sapiens_hsa049710.65805657
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64966532
106Dilated cardiomyopathy_Homo sapiens_hsa054140.64575005
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64348052
108Rap1 signaling pathway_Homo sapiens_hsa040150.63633218
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63625538
110VEGF signaling pathway_Homo sapiens_hsa043700.63203638
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63005918
112Hepatitis B_Homo sapiens_hsa051610.62975385
113Antigen processing and presentation_Homo sapiens_hsa046120.62952642
114Olfactory transduction_Homo sapiens_hsa047400.62939892
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62812965
116Inositol phosphate metabolism_Homo sapiens_hsa005620.62744341
117Endometrial cancer_Homo sapiens_hsa052130.62075547
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.61755719
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61699557
120GnRH signaling pathway_Homo sapiens_hsa049120.61565086
121Prostate cancer_Homo sapiens_hsa052150.61134046
122Dopaminergic synapse_Homo sapiens_hsa047280.60005673
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.59809140

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