ZEB2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)9.78991519
2regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)8.84168262
3positive regulation of interleukin-17 production (GO:0032740)8.45845417
4positive regulation of cell fate commitment (GO:0010455)8.30749053
5positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.27185687
6nucleoside transmembrane transport (GO:1901642)8.01448135
7negative regulation of interleukin-10 production (GO:0032693)7.11725792
8positive regulation of defense response to virus by host (GO:0002230)7.05360364
9regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.04105484
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.99656955
11positive regulation of T-helper 1 type immune response (GO:0002827)6.95785914
12regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.90372899
13cellular response to gamma radiation (GO:0071480)6.45687412
14ribosomal small subunit biogenesis (GO:0042274)6.29604496
15positive regulation of T-helper cell differentiation (GO:0045624)6.21374905
16synapsis (GO:0007129)6.12760456
17cell wall macromolecule metabolic process (GO:0044036)6.09784622
18L-fucose catabolic process (GO:0042355)6.08075150
19fucose catabolic process (GO:0019317)6.08075150
20L-fucose metabolic process (GO:0042354)6.08075150
21pyrimidine nucleotide catabolic process (GO:0006244)6.02066829
22microtubule severing (GO:0051013)5.57141839
23nucleoside transport (GO:0015858)5.55384903
24positive regulation of alpha-beta T cell proliferation (GO:0046641)5.49882749
25cellular anion homeostasis (GO:0030002)5.18122396
26positive regulation of T cell mediated cytotoxicity (GO:0001916)5.16026572
27positive regulation of natural killer cell activation (GO:0032816)4.91605422
28regulation of T-helper 1 type immune response (GO:0002825)4.81195291
29positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)4.77585270
30DNA double-strand break processing (GO:0000729)4.70672290
31positive regulation of activated T cell proliferation (GO:0042104)4.69137601
32positive regulation of neutrophil chemotaxis (GO:0090023)4.67257545
33positive regulation of neutrophil migration (GO:1902624)4.67257545
34behavioral response to nicotine (GO:0035095)4.58547561
35C4-dicarboxylate transport (GO:0015740)4.57123014
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.53597927
37viral transcription (GO:0019083)4.42752220
38regulation of interleukin-17 production (GO:0032660)4.38216131
39translational termination (GO:0006415)4.36713254
40regulation of T cell mediated cytotoxicity (GO:0001914)4.35723415
41regulation of T-helper cell differentiation (GO:0045622)4.35399927
42positive regulation of granulocyte chemotaxis (GO:0071624)4.21995793
43male meiosis I (GO:0007141)4.20013406
44positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.19198688
45positive regulation of osteoclast differentiation (GO:0045672)4.12765054
46neurofilament cytoskeleton organization (GO:0060052)4.12684559
47pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.03091559
48positive regulation of NF-kappaB import into nucleus (GO:0042346)4.01146151
49neuronal action potential propagation (GO:0019227)3.97133613
50regulation of alpha-beta T cell proliferation (GO:0046640)3.95758860
51opioid receptor signaling pathway (GO:0038003)3.90334785
52basic amino acid transport (GO:0015802)3.79868506
53labyrinthine layer development (GO:0060711)3.77492512
54regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.75828602
55regulation of neutrophil chemotaxis (GO:0090022)3.69738592
56regulation of neutrophil migration (GO:1902622)3.69738592
57transcription elongation from RNA polymerase I promoter (GO:0006362)3.67034314
58regulation of defense response to virus by host (GO:0050691)3.66232838
59regulation of natural killer cell activation (GO:0032814)3.55114520
60relaxation of smooth muscle (GO:0044557)3.48900245
61translational elongation (GO:0006414)3.45889439
62L-serine transport (GO:0015825)3.43581449
63positive regulation of chemokine secretion (GO:0090197)3.36695586
64regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.36187352
65glucosamine-containing compound catabolic process (GO:1901072)3.32836441
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.31711412
67base-excision repair, AP site formation (GO:0006285)3.27786876
68alanine transport (GO:0032328)3.26988770
69hydrogen peroxide biosynthetic process (GO:0050665)3.26768399
70cotranslational protein targeting to membrane (GO:0006613)3.26200220
71female gamete generation (GO:0007292)3.25156757
72protein targeting to ER (GO:0045047)3.23703401
73positive regulation of tissue remodeling (GO:0034105)3.21430795
74regulation of cell fate commitment (GO:0010453)3.20742270
75regulation of activated T cell proliferation (GO:0046006)3.19791423
76cellular protein complex disassembly (GO:0043624)3.19718041
77DNA deamination (GO:0045006)3.18082672
78production of molecular mediator involved in inflammatory response (GO:0002532)3.17758152
79gamma-aminobutyric acid transport (GO:0015812)3.17143547
80viral life cycle (GO:0019058)3.12201917
81icosanoid transport (GO:0071715)3.11171937
82fatty acid derivative transport (GO:1901571)3.11171937
83positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09300156
84deoxyribonucleotide catabolic process (GO:0009264)3.08876547
85regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.08030631
86establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06803896
87meiosis I (GO:0007127)3.06771571
88positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.00453949
89regulation of sensory perception (GO:0051931)3.00118851
90regulation of sensory perception of pain (GO:0051930)3.00118851
91protein localization to endoplasmic reticulum (GO:0070972)2.98013772
92protein localization to cilium (GO:0061512)2.95837505
93positive regulation of interleukin-12 production (GO:0032735)2.95565840
94serine transport (GO:0032329)2.95297894
95regulation of protein heterodimerization activity (GO:0043497)2.91956841
96reactive oxygen species biosynthetic process (GO:1903409)2.90929712
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87780091
98auditory receptor cell stereocilium organization (GO:0060088)2.87510411
99regulation of memory T cell differentiation (GO:0043380)12.8704977
100regulation of activation of Janus kinase activity (GO:0010533)11.1051689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela5.68277673
2GATA1_22025678_ChIP-Seq_K562_Human4.26578761
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32519932
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.10549080
5VDR_22108803_ChIP-Seq_LS180_Human3.08848388
6EZH2_22144423_ChIP-Seq_EOC_Human3.06940979
7EWS_26573619_Chip-Seq_HEK293_Human2.74541283
8IGF1R_20145208_ChIP-Seq_DFB_Human2.71639603
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.60327167
10TAF2_19829295_ChIP-Seq_ESCs_Human2.33855659
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.13864991
12ER_23166858_ChIP-Seq_MCF-7_Human1.99575786
13TAF15_26573619_Chip-Seq_HEK293_Human1.99154674
14BCAT_22108803_ChIP-Seq_LS180_Human1.98121808
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84564894
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82295924
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.79794042
18GBX2_23144817_ChIP-Seq_PC3_Human1.77568994
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76309233
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75932877
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.73012206
22TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71142620
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69757055
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69025192
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68191873
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67855266
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62139149
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61617695
29HTT_18923047_ChIP-ChIP_STHdh_Human1.59635351
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52282372
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51515511
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48615572
33REST_21632747_ChIP-Seq_MESCs_Mouse1.47727306
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47572467
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.45615996
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44895938
37ERG_20517297_ChIP-Seq_VCAP_Human1.42930667
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41773717
39SOX2_19829295_ChIP-Seq_ESCs_Human1.41371999
40NANOG_19829295_ChIP-Seq_ESCs_Human1.41371999
41NCOR_22424771_ChIP-Seq_293T_Human1.40704933
42SMAD3_21741376_ChIP-Seq_ESCs_Human1.39266451
43GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.39256120
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38143207
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35646091
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35180753
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.34363543
48RNF2_27304074_Chip-Seq_NSC_Mouse1.33807311
49CBP_20019798_ChIP-Seq_JUKART_Human1.30224252
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30224252
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.28718472
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24729738
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23171582
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21940211
55TCF4_22108803_ChIP-Seq_LS180_Human1.18421899
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.17340195
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.16728273
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14649074
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14649074
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14410680
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13156022
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11928577
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10244672
64DROSHA_22980978_ChIP-Seq_HELA_Human1.09221752
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07828221
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.06932437
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05155300
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.04758963
69SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04276004
70ERA_21632823_ChIP-Seq_H3396_Human1.03571880
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03497069
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02536414
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02008397
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01751345
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01327438
76OCT4_20526341_ChIP-Seq_ESCs_Human1.00166776
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99271226
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96490502
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96475221
80AR_21572438_ChIP-Seq_LNCaP_Human0.96083613
81NANOG_20526341_ChIP-Seq_ESCs_Human0.96077205
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95850338
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94273509
84P53_21459846_ChIP-Seq_SAOS-2_Human0.94047187
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94022481
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93307551
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92566521
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92185238
89CDX2_22108803_ChIP-Seq_LS180_Human0.92133882
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91887782
91TCF4_23295773_ChIP-Seq_U87_Human0.91760397
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91376610
93MYC_19829295_ChIP-Seq_ESCs_Human0.91255030
94IRF1_19129219_ChIP-ChIP_H3396_Human0.91157126
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90814258
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90198960
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90139758
98STAT3_23295773_ChIP-Seq_U87_Human0.89371963
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89102458
100MYC_18940864_ChIP-ChIP_HL60_Human0.88772892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.58469214
2MP0003303_peritoneal_inflammation4.83051003
3MP0002102_abnormal_ear_morphology4.25908693
4MP0001984_abnormal_olfaction4.23134136
5MP0005360_urolithiasis3.83373640
6MP0010386_abnormal_urinary_bladder3.04836224
7MP0003252_abnormal_bile_duct3.01442301
8MP0002876_abnormal_thyroid_physiology2.82502398
9MP0002160_abnormal_reproductive_system2.66309800
10MP0002837_dystrophic_cardiac_calcinosis2.61983930
11MP0005085_abnormal_gallbladder_physiolo2.42669366
12MP0003646_muscle_fatigue2.40592947
13MP0005389_reproductive_system_phenotype2.37421790
14MP0009046_muscle_twitch2.32202472
15MP0008872_abnormal_physiological_respon2.24005439
16MP0001661_extended_life_span2.15315071
17MP0004885_abnormal_endolymph2.11121442
18MP0009785_altered_susceptibility_to2.08915987
19MP0009765_abnormal_xenobiotic_induced2.06402843
20MP0005248_abnormal_Harderian_gland1.96950518
21MP0003878_abnormal_ear_physiology1.87626907
22MP0005377_hearing/vestibular/ear_phenot1.87626907
23MP0000372_irregular_coat_pigmentation1.82292919
24MP0005551_abnormal_eye_electrophysiolog1.75605278
25MP0006292_abnormal_olfactory_placode1.68861902
26MP0001919_abnormal_reproductive_system1.63609276
27MP0009379_abnormal_foot_pigmentation1.61912499
28MP0002282_abnormal_trachea_morphology1.59749439
29MP0005671_abnormal_response_to1.59619425
30MP0009745_abnormal_behavioral_response1.45253804
31MP0002638_abnormal_pupillary_reflex1.44807896
32MP0001542_abnormal_bone_strength1.40164947
33MP0004142_abnormal_muscle_tone1.36020395
34MP0003880_abnormal_central_pattern1.25208678
35MP0003136_yellow_coat_color1.22672745
36MP0003828_pulmonary_edema1.19125489
37MP0002736_abnormal_nociception_after1.19016061
38MP0001764_abnormal_homeostasis1.17961771
39MP0000685_abnormal_immune_system1.15950949
40MP0005171_absent_coat_pigmentation1.15585697
41MP0003300_gastrointestinal_ulcer1.14962204
42MP0005646_abnormal_pituitary_gland1.12086608
43MP0000538_abnormal_urinary_bladder1.10187789
44MP0001501_abnormal_sleep_pattern1.07259639
45MP0001324_abnormal_eye_pigmentation1.06673779
46MP0002249_abnormal_larynx_morphology1.05048374
47MP0003195_calcinosis1.04763818
48MP0002132_abnormal_respiratory_system1.04694960
49MP0010155_abnormal_intestine_physiology1.04119061
50MP0002064_seizures1.04081322
51MP0002090_abnormal_vision1.03261667
52MP0001663_abnormal_digestive_system1.02717129
53MP0001968_abnormal_touch/_nociception1.01075571
54MP0001835_abnormal_antigen_presentation0.98539908
55MP0000631_abnormal_neuroendocrine_gland0.97221278
56MP0010030_abnormal_orbit_morphology0.96494159
57MP0005647_abnormal_sex_gland0.94675100
58MP0001790_abnormal_immune_system0.94014505
59MP0005387_immune_system_phenotype0.94014505
60MP0001800_abnormal_humoral_immune0.93201390
61MP0002277_abnormal_respiratory_mucosa0.91248974
62MP0005000_abnormal_immune_tolerance0.85664327
63MP0000470_abnormal_stomach_morphology0.85266620
64MP0005636_abnormal_mineral_homeostasis0.84674561
65MP0003638_abnormal_response/metabolism_0.84085960
66MP0000163_abnormal_cartilage_morphology0.83967618
67MP0002332_abnormal_exercise_endurance0.83170433
68MP0000613_abnormal_salivary_gland0.82683671
69MP0001970_abnormal_pain_threshold0.80796585
70MP0000026_abnormal_inner_ear0.79159640
71MP0001270_distended_abdomen0.75768041
72MP0001119_abnormal_female_reproductive0.74170071
73MP0000678_abnormal_parathyroid_gland0.72791254
74MP0005381_digestive/alimentary_phenotyp0.72256338
75MP0005195_abnormal_posterior_eye0.71852453
76MP0002184_abnormal_innervation0.71743354
77MP0003866_abnormal_defecation0.71188761
78MP0005503_abnormal_tendon_morphology0.71102932
79MP0001963_abnormal_hearing_physiology0.69410770
80MP0000230_abnormal_systemic_arterial0.68866051
81MP0002138_abnormal_hepatobiliary_system0.67880846
82MP0002272_abnormal_nervous_system0.67100061
83MP0000427_abnormal_hair_cycle0.66409854
84MP0005253_abnormal_eye_physiology0.65731730
85MP0004742_abnormal_vestibular_system0.65149956
86MP0000343_altered_response_to0.64424124
87MP0008874_decreased_physiological_sensi0.64014226
88MP0004924_abnormal_behavior0.62995870
89MP0005386_behavior/neurological_phenoty0.62995870
90MP0001905_abnormal_dopamine_level0.62350924
91MP0005408_hypopigmentation0.62070578
92MP0002735_abnormal_chemical_nociception0.61444306
93MP0004130_abnormal_muscle_cell0.61000282
94MP0005332_abnormal_amino_acid0.60670379
95MP0001486_abnormal_startle_reflex0.59742457
96MP0003283_abnormal_digestive_organ0.58806169
97MP0009763_increased_sensitivity_to0.58798840
98MP0005645_abnormal_hypothalamus_physiol0.58791827
99MP0002734_abnormal_mechanical_nocicepti0.58776862
100MP0002733_abnormal_thermal_nociception0.58715361

Predicted human phenotypes

RankGene SetZ-score
1Decreased subcutaneous fat (HP:0001002)8.21042691
2Fragile nails (HP:0001808)7.82533541
3Conjugated hyperbilirubinemia (HP:0002908)6.66894513
4Erythroderma (HP:0001019)6.37725171
5Congenital ichthyosiform erythroderma (HP:0007431)6.31687070
6Brittle hair (HP:0002299)6.21808271
7Abnormality of subcutaneous fat tissue (HP:0001001)6.18844536
8Congenital sensorineural hearing impairment (HP:0008527)4.47722880
9Congenital stationary night blindness (HP:0007642)4.22055018
10IgG deficiency (HP:0004315)4.09876251
11Hyperalaninemia (HP:0003348)3.66798439
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.66798439
13Abnormality of alanine metabolism (HP:0010916)3.66798439
14Genetic anticipation (HP:0003743)3.40207177
15Thyroid-stimulating hormone excess (HP:0002925)3.33007676
16Depressed nasal tip (HP:0000437)3.32462089
17Parakeratosis (HP:0001036)3.22005979
18Adrenal hypoplasia (HP:0000835)3.21518077
19Degeneration of anterior horn cells (HP:0002398)3.21070449
20Abnormality of the anterior horn cell (HP:0006802)3.21070449
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18703023
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.18703023
23Progressive cerebellar ataxia (HP:0002073)3.14493942
24High pitched voice (HP:0001620)2.84549895
25Bulbous nose (HP:0000414)2.83794514
26Macrocytic anemia (HP:0001972)2.76101346
27Neoplasm of head and neck (HP:0012288)2.72390436
28Esophageal neoplasm (HP:0100751)2.72390436
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.70475293
30Hypoplasia of the fovea (HP:0007750)2.70475293
31Metaphyseal dysplasia (HP:0100255)2.67239808
32Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60648740
33Cutaneous photosensitivity (HP:0000992)2.57862226
34Abnormality of the corticospinal tract (HP:0002492)2.55831745
35Retrobulbar optic neuritis (HP:0100654)2.42864377
36Optic neuritis (HP:0100653)2.42864377
37Pancreatic cysts (HP:0001737)2.35530071
38Ectopic kidney (HP:0000086)2.30242564
39Opisthotonus (HP:0002179)2.29136481
40Attenuation of retinal blood vessels (HP:0007843)2.28789884
41Abnormality of dental color (HP:0011073)2.26104755
42Absent thumb (HP:0009777)2.19862611
43Clubbing of toes (HP:0100760)2.18428521
44Abnormality of the ileum (HP:0001549)2.17499924
45Aplasia/Hypoplasia of the macula (HP:0008059)2.16651057
46Abnormality of the fovea (HP:0000493)2.16612380
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.15214709
48Squamous cell carcinoma (HP:0002860)2.11757564
49Pallor (HP:0000980)2.07874946
50Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06337221
51Absent epiphyses (HP:0010577)2.06337221
52Asthma (HP:0002099)2.06283542
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05933976
54Mediastinal lymphadenopathy (HP:0100721)2.05479722
55Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05235508
56Abnormal rod and cone electroretinograms (HP:0008323)2.04135274
57Barrel-shaped chest (HP:0001552)2.00579492
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.4220166
59Pancreatic islet-cell hyperplasia (HP:0004510)1.98715572
60Increased serum pyruvate (HP:0003542)1.97592937
61Partial agenesis of the corpus callosum (HP:0001338)1.97131121
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.95406461
63Hypoplasia of the radius (HP:0002984)1.94864422
64Recurrent sinusitis (HP:0011108)1.93907200
65Abnormality of the vocal cords (HP:0008777)1.91507947
66Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91314906
67Decreased central vision (HP:0007663)1.88936644
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88771395
69Optic nerve hypoplasia (HP:0000609)1.81967468
70Intestinal atresia (HP:0011100)1.81568492
71Orchitis (HP:0100796)1.80839793
72Nephrocalcinosis (HP:0000121)1.77283515
73Horizontal nystagmus (HP:0000666)1.74904860
74Fibular aplasia (HP:0002990)1.71632509
75Aplastic anemia (HP:0001915)1.70780018
76Hypoplasia of the uterus (HP:0000013)1.69134530
77Abnormal number of incisors (HP:0011064)1.67748119
78Pigmentary retinal degeneration (HP:0001146)1.67613064
79Cutaneous melanoma (HP:0012056)1.65459645
80Atrophy/Degeneration involving motor neurons (HP:0007373)1.65283300
81True hermaphroditism (HP:0010459)1.65096226
82Morphological abnormality of the pyramidal tract (HP:0002062)1.64569339
83Mesomelia (HP:0003027)1.64029578
84Increased cerebral lipofuscin (HP:0011813)1.63991250
85Gaze-evoked nystagmus (HP:0000640)1.62105147
86Abnormal ciliary motility (HP:0012262)1.61598086
87Meckel diverticulum (HP:0002245)1.59025719
88Clumsiness (HP:0002312)1.58790463
89Keratoconjunctivitis (HP:0001096)1.57990307
90Abnormality of the lower motor neuron (HP:0002366)1.57701159
91Volvulus (HP:0002580)1.57697740
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.57584921
93Absent/shortened dynein arms (HP:0200106)1.57584921
94Stomatitis (HP:0010280)1.57408251
95Keratoconjunctivitis sicca (HP:0001097)1.57335248
96Abnormality of glycolysis (HP:0004366)1.55989024
97Spastic paraparesis (HP:0002313)1.54659983
98Oral leukoplakia (HP:0002745)1.52901456
99Abnormal respiratory motile cilium morphology (HP:0005938)1.52581960
100Abnormal respiratory epithelium morphology (HP:0012253)1.52581960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.36061027
2MAP3K95.11990564
3ERN14.57411857
4TIE13.47884009
5ADRBK23.32468854
6MAPKAPK33.10798822
7ADRBK12.78617328
8ARAF2.75623334
9STK32.48660095
10PINK12.30828313
11EEF2K2.28083437
12PTK62.10360353
13JAK31.85832858
14FRK1.79633076
15STK111.73001308
16ITK1.67567928
17MUSK1.62202402
18MAP3K131.59409550
19ACVR1B1.55652135
20GRK11.53112250
21BMPR1B1.45595171
22WNK31.18262294
23BCKDK1.17346962
24TRPM71.15441675
25LATS11.14411606
26RPS6KB21.13980339
27NUAK11.12861251
28PRKCG1.10596616
29MATK1.09985800
30MAP3K121.08319571
31CDK191.08105595
32MARK31.05133793
33PRKCE1.04362916
34PRKCI1.00365904
35PIK3CG0.95721329
36MOS0.94402272
37MAPKAPK50.92043037
38CAMK2D0.88474192
39MAPK130.88149734
40CAMK2B0.87846951
41PRKCZ0.82689571
42PRKCH0.81059277
43TAOK30.81042383
44CDK70.79869495
45TEC0.77433518
46NTRK20.76565584
47CAMK2G0.74048893
48PRKCD0.73482247
49PDK10.70655499
50IRAK40.66955598
51CAMKK20.66704508
52JAK20.65527013
53FGFR30.65262522
54KSR20.63245981
55PIK3CA0.58655017
56PIM20.55605931
57TXK0.55206893
58MAP4K20.54094927
59MAP2K10.53563587
60BRAF0.52720301
61TGFBR10.51662357
62MAPK120.50513869
63MAP3K40.50176008
64CSK0.47884507
65SIK30.46566404
66FES0.44771697
67ERBB30.44385545
68NEK10.43398611
69INSRR0.42836104
70CSNK1D0.42779166
71CAMKK10.42509957
72WNK40.41813962
73PRKCQ0.41776426
74PRKCA0.39891013
75KSR10.39839290
76TYK20.39618555
77CAMK2A0.39397273
78OBSCN0.37143008
79PKN10.36135603
80PDPK10.35159900
81MINK10.34629803
82MAP4K10.34299116
83MST1R0.33912872
84TRIM280.33377881
85PRKCB0.32757104
86RPS6KA20.32319158
87IGF1R0.31464420
88BCR0.30491289
89IKBKE0.29221788
90MAP2K40.29141718
91TNIK0.28789858
92TGFBR20.26000106
93PRKACA0.24462507
94PRKACB0.24304869
95MAP2K70.23525870
96MAP2K20.23290770
97SYK0.23171237
98CSF1R0.22377408
99WNK10.21731785
100PLK40.20855172

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.94097273
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.59810614
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.88377884
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.23745391
5Phototransduction_Homo sapiens_hsa047443.13700712
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.90990990
7Basal transcription factors_Homo sapiens_hsa030222.83195070
8Nucleotide excision repair_Homo sapiens_hsa034202.70177581
9Selenocompound metabolism_Homo sapiens_hsa004502.58777629
10Pertussis_Homo sapiens_hsa051332.28271549
11Rheumatoid arthritis_Homo sapiens_hsa053232.22829537
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.96473238
13Histidine metabolism_Homo sapiens_hsa003401.89257616
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72002460
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71304863
16Nitrogen metabolism_Homo sapiens_hsa009101.69468213
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40103401
18ABC transporters_Homo sapiens_hsa020101.39997350
19Pyrimidine metabolism_Homo sapiens_hsa002401.37462038
20Linoleic acid metabolism_Homo sapiens_hsa005911.36674075
21Asthma_Homo sapiens_hsa053101.35347497
22Staphylococcus aureus infection_Homo sapiens_hsa051501.32059798
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28662707
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.28572229
25Allograft rejection_Homo sapiens_hsa053301.24167579
26Nicotine addiction_Homo sapiens_hsa050331.19997095
27mTOR signaling pathway_Homo sapiens_hsa041501.19779241
28Autoimmune thyroid disease_Homo sapiens_hsa053201.18031640
29Tryptophan metabolism_Homo sapiens_hsa003801.16323571
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.10800343
31Taste transduction_Homo sapiens_hsa047421.10191517
32Chemical carcinogenesis_Homo sapiens_hsa052041.06484508
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05701203
34Collecting duct acid secretion_Homo sapiens_hsa049661.02234220
35Fat digestion and absorption_Homo sapiens_hsa049751.01269283
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98693506
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97843652
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95456529
39RNA polymerase_Homo sapiens_hsa030200.95331696
40Ovarian steroidogenesis_Homo sapiens_hsa049130.94004218
41Base excision repair_Homo sapiens_hsa034100.93528157
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92468032
43Malaria_Homo sapiens_hsa051440.90918369
44beta-Alanine metabolism_Homo sapiens_hsa004100.89889918
45Retinol metabolism_Homo sapiens_hsa008300.87636217
46Morphine addiction_Homo sapiens_hsa050320.85724745
47Arginine and proline metabolism_Homo sapiens_hsa003300.84320731
48Oxidative phosphorylation_Homo sapiens_hsa001900.81627450
49Tuberculosis_Homo sapiens_hsa051520.79127813
50African trypanosomiasis_Homo sapiens_hsa051430.78375254
51Cocaine addiction_Homo sapiens_hsa050300.75994305
52Arachidonic acid metabolism_Homo sapiens_hsa005900.73686657
53Bile secretion_Homo sapiens_hsa049760.72989530
54Long-term depression_Homo sapiens_hsa047300.70584113
55Glycerolipid metabolism_Homo sapiens_hsa005610.69673217
56Cholinergic synapse_Homo sapiens_hsa047250.69381410
57Hematopoietic cell lineage_Homo sapiens_hsa046400.68684333
58Olfactory transduction_Homo sapiens_hsa047400.67868065
59Peroxisome_Homo sapiens_hsa041460.67086817
60Circadian entrainment_Homo sapiens_hsa047130.63443852
61Glutamatergic synapse_Homo sapiens_hsa047240.59305878
62Parkinsons disease_Homo sapiens_hsa050120.57722955
63Hedgehog signaling pathway_Homo sapiens_hsa043400.57658908
64Type I diabetes mellitus_Homo sapiens_hsa049400.56908438
65Sulfur metabolism_Homo sapiens_hsa009200.55854279
66Graft-versus-host disease_Homo sapiens_hsa053320.55039252
67Serotonergic synapse_Homo sapiens_hsa047260.54423283
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53056371
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51060497
70Prion diseases_Homo sapiens_hsa050200.48666952
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.48585856
72Primary immunodeficiency_Homo sapiens_hsa053400.48316567
73Dilated cardiomyopathy_Homo sapiens_hsa054140.46824965
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45178858
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44521793
76Leishmaniasis_Homo sapiens_hsa051400.43469665
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42608827
78Fanconi anemia pathway_Homo sapiens_hsa034600.41141158
79Synaptic vesicle cycle_Homo sapiens_hsa047210.38028096
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37521748
81Tyrosine metabolism_Homo sapiens_hsa003500.36844127
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36546003
83AMPK signaling pathway_Homo sapiens_hsa041520.33980071
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.33053644
85Metabolic pathways_Homo sapiens_hsa011000.30685691
86Caffeine metabolism_Homo sapiens_hsa002320.29440299
87Systemic lupus erythematosus_Homo sapiens_hsa053220.28685201
88Cardiac muscle contraction_Homo sapiens_hsa042600.28103051
89Renin secretion_Homo sapiens_hsa049240.26888761
90Pancreatic secretion_Homo sapiens_hsa049720.26546324
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25706595
92RNA degradation_Homo sapiens_hsa030180.25506771
93Regulation of autophagy_Homo sapiens_hsa041400.24917144
94One carbon pool by folate_Homo sapiens_hsa006700.24245967
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24124824
96Salivary secretion_Homo sapiens_hsa049700.23659587
97Chemokine signaling pathway_Homo sapiens_hsa040620.23001948
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21350764
99Calcium signaling pathway_Homo sapiens_hsa040200.21051398
100Melanoma_Homo sapiens_hsa052180.20551992

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