ZER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66769988
2locomotory exploration behavior (GO:0035641)5.64558982
3synaptic vesicle maturation (GO:0016188)5.45539537
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28834657
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10858617
6vocalization behavior (GO:0071625)5.06983702
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83587262
8synaptic vesicle exocytosis (GO:0016079)4.72509916
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.59771951
10regulation of glutamate receptor signaling pathway (GO:1900449)4.57422126
11regulation of synaptic vesicle exocytosis (GO:2000300)4.56820015
12glutamate secretion (GO:0014047)4.55034126
13neuronal action potential propagation (GO:0019227)4.41411743
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.39860289
15neuron cell-cell adhesion (GO:0007158)4.24917075
16protein localization to synapse (GO:0035418)4.21491550
17regulation of neuronal synaptic plasticity (GO:0048168)4.19176451
18exploration behavior (GO:0035640)4.17203235
19regulation of synaptic vesicle transport (GO:1902803)4.09257125
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08845456
21neurotransmitter secretion (GO:0007269)4.08687883
22synaptic transmission, glutamatergic (GO:0035249)4.05822719
23gamma-aminobutyric acid transport (GO:0015812)3.99340764
24glutamate receptor signaling pathway (GO:0007215)3.95705053
25dendritic spine morphogenesis (GO:0060997)3.92118578
26long-term memory (GO:0007616)3.84974397
27transmission of nerve impulse (GO:0019226)3.84253260
28layer formation in cerebral cortex (GO:0021819)3.82222645
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80131913
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76924333
31neuron-neuron synaptic transmission (GO:0007270)3.74799356
32regulation of synapse structural plasticity (GO:0051823)3.73120651
33cerebellar granule cell differentiation (GO:0021707)3.69837230
34cellular potassium ion homeostasis (GO:0030007)3.68058185
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.64657775
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60289052
37positive regulation of membrane potential (GO:0045838)3.57896522
38neurotransmitter-gated ion channel clustering (GO:0072578)3.56495753
39negative regulation of erythrocyte differentiation (GO:0045647)3.46258052
40neuronal ion channel clustering (GO:0045161)3.46097714
41glycine transport (GO:0015816)3.42705320
42neurotransmitter transport (GO:0006836)3.41776423
43regulation of postsynaptic membrane potential (GO:0060078)3.41007102
44neuron recognition (GO:0008038)3.34698638
45sodium ion export (GO:0071436)3.34074307
46L-amino acid import (GO:0043092)3.33428589
47regulation of synaptic plasticity (GO:0048167)3.33073814
48activation of protein kinase A activity (GO:0034199)3.32794357
49proline transport (GO:0015824)3.30575431
50regulation of dendritic spine morphogenesis (GO:0061001)3.28887471
51neuromuscular process controlling posture (GO:0050884)3.27649804
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27031618
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26058247
54synaptic vesicle endocytosis (GO:0048488)3.24375963
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.24336850
56cerebellar Purkinje cell differentiation (GO:0021702)3.22168950
57long-term synaptic potentiation (GO:0060291)3.22119518
58neuromuscular process controlling balance (GO:0050885)3.21035350
59regulation of vesicle fusion (GO:0031338)3.18143692
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17463740
61regulation of neurotransmitter secretion (GO:0046928)3.16316450
62regulation of neurotransmitter levels (GO:0001505)3.14902906
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12818979
64membrane depolarization during action potential (GO:0086010)3.12564068
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10219861
66presynaptic membrane assembly (GO:0097105)3.09773561
67auditory behavior (GO:0031223)3.08284339
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07859448
69prepulse inhibition (GO:0060134)3.07795801
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07216605
71axonal fasciculation (GO:0007413)3.06037875
72membrane depolarization (GO:0051899)3.05819064
73dendrite morphogenesis (GO:0048813)3.05744682
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.04401806
75regulation of ARF protein signal transduction (GO:0032012)3.03008195
76membrane hyperpolarization (GO:0060081)3.02228974
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02130128
78presynaptic membrane organization (GO:0097090)3.01221246
79positive regulation of neurotransmitter secretion (GO:0001956)3.00702181
80positive regulation of neurotransmitter transport (GO:0051590)2.97921902
81postsynaptic membrane organization (GO:0001941)2.96896184
82signal complex assembly (GO:0007172)2.95770808
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95762073
84adult walking behavior (GO:0007628)2.95625523
85regulation of neurotransmitter transport (GO:0051588)2.94591000
86potassium ion import (GO:0010107)2.93370989
87response to auditory stimulus (GO:0010996)2.92048039
88positive regulation of synapse maturation (GO:0090129)2.90099788
89cell communication by electrical coupling (GO:0010644)2.89789239
90protein targeting to plasma membrane (GO:0072661)2.89736470
91learning (GO:0007612)2.89280142
92dendritic spine organization (GO:0097061)2.86852336
93mating behavior (GO:0007617)2.85796799
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84815050
95central nervous system myelination (GO:0022010)2.84645346
96axon ensheathment in central nervous system (GO:0032291)2.84645346
97regulation of dendritic spine development (GO:0060998)2.84447243
98positive regulation of dendritic spine development (GO:0060999)2.84058617
99chemosensory behavior (GO:0007635)2.83874201
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83145293
101positive regulation of Rap GTPase activity (GO:0032854)2.82846513
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81976597
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81515781
104protein localization to endosome (GO:0036010)2.80322650
105amino acid import (GO:0043090)2.80185689
106positive regulation of synaptic transmission (GO:0050806)2.80182696
107regulation of voltage-gated calcium channel activity (GO:1901385)2.79427631
108regulation of synaptic transmission (GO:0050804)2.79030872
109peptidyl-tyrosine autophosphorylation (GO:0038083)2.75883335
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74351312
111negative regulation of cell killing (GO:0031342)2.74351312
112cellular response to monoamine stimulus (GO:0071868)2.74304067
113cellular response to catecholamine stimulus (GO:0071870)2.74304067
114positive regulation of receptor recycling (GO:0001921)2.64257956
115regulation of ARF GTPase activity (GO:0032312)2.57854830
116positive regulation of protein dephosphorylation (GO:0035307)2.54731144
117cellular response to epinephrine stimulus (GO:0071872)2.52719549
118positive regulation of fibroblast migration (GO:0010763)2.49258714
119barbed-end actin filament capping (GO:0051016)2.47244539
120regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45831878
121regulation of early endosome to late endosome transport (GO:2000641)2.43127309
122regulation of synapse maturation (GO:0090128)2.42772957
123regulation of Rap GTPase activity (GO:0032317)2.42598342
124creatine metabolic process (GO:0006600)2.32191948
125actin filament capping (GO:0051693)2.31572056
126cell-substrate adherens junction assembly (GO:0007045)2.31117213
127focal adhesion assembly (GO:0048041)2.31117213
128stress fiber assembly (GO:0043149)2.30834332
129dopamine receptor signaling pathway (GO:0007212)2.30826029
130adherens junction assembly (GO:0034333)2.29860961
131regulation of T-helper 2 cell differentiation (GO:0045628)2.27470686
132response to parathyroid hormone (GO:0071107)2.27147507
133potassium ion homeostasis (GO:0055075)2.22721726
134cellular sodium ion homeostasis (GO:0006883)2.22089264
135response to catecholamine (GO:0071869)2.20066162
136response to monoamine (GO:0071867)2.20066162
137mannose metabolic process (GO:0006013)2.19512885
138regulation of amyloid precursor protein catabolic process (GO:1902991)2.17211102
139regulation of regulated secretory pathway (GO:1903305)2.16562682
140cell communication involved in cardiac conduction (GO:0086065)2.14823387
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13687291
142gas transport (GO:0015669)2.13494974
143oxygen transport (GO:0015671)2.13420327
144negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.12976547
145actin filament polymerization (GO:0030041)2.10400184
146cell migration in hindbrain (GO:0021535)2.09429124
147adenosine receptor signaling pathway (GO:0001973)2.08157894
148regulation of protein dephosphorylation (GO:0035304)2.06890838
149NADH metabolic process (GO:0006734)2.05877564
150cardiac muscle contraction (GO:0060048)2.05810158
151regulation of extracellular matrix disassembly (GO:0010715)2.04431560
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.03754979
153negative regulation of myotube differentiation (GO:0010832)2.03499816
154regulation of clathrin-mediated endocytosis (GO:2000369)2.01270063
155regulation of platelet aggregation (GO:0090330)1.98393953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74499920
2GBX2_23144817_ChIP-Seq_PC3_Human3.22609097
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93131547
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90800811
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86670897
6DROSHA_22980978_ChIP-Seq_HELA_Human2.69262895
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64303884
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64303884
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63863195
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.59055730
11LXR_22292898_ChIP-Seq_THP-1_Human2.58193226
12REST_21632747_ChIP-Seq_MESCs_Mouse2.55939818
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49263078
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48228328
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47859386
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44155915
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.34349222
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33814885
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32776353
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25254957
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23643180
22KDM2B_26808549_Chip-Seq_DND41_Human2.16503903
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15523835
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13367530
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.11127407
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.10964167
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.10536179
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.08638193
29* TCF7_22412390_ChIP-Seq_EML_Mouse2.00969008
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00651258
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00269633
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87823825
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87774510
34RACK7_27058665_Chip-Seq_MCF-7_Human1.86034468
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.85171394
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83769013
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79647894
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79041916
39VDR_21846776_ChIP-Seq_THP-1_Human1.77895457
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72939396
41AR_21572438_ChIP-Seq_LNCaP_Human1.65071528
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.58988702
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.55915684
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52254642
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50809087
46* SMC4_20622854_ChIP-Seq_HELA_Human1.50312369
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.49254023
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45935572
49SMAD4_21799915_ChIP-Seq_A2780_Human1.44680567
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42527969
51CREB1_26743006_Chip-Seq_LNCaP_Human1.42238523
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42112375
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41903989
54GATA1_19941826_ChIP-Seq_K562_Human1.40074060
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38131201
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37782642
57TAF15_26573619_Chip-Seq_HEK293_Human1.35989779
58* P68_20966046_ChIP-Seq_HELA_Human1.35880790
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33979510
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33597534
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33353652
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.31761087
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31620027
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.31023248
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29954745
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29818239
67MYC_22102868_ChIP-Seq_BL_Human1.29122054
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27960671
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27465883
70VDR_24763502_ChIP-Seq_THP-1_Human1.26906516
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25983859
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25498525
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24932653
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24124192
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23460182
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22818835
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22655010
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21878945
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21243409
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.21206738
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19998426
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19989272
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.19946633
84ZNF274_21170338_ChIP-Seq_K562_Hela1.19425371
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.19250143
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.18849207
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18195538
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18175942
89AR_19668381_ChIP-Seq_PC3_Human1.17126112
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16915631
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16728433
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16251837
93STAT3_23295773_ChIP-Seq_U87_Human1.14449520
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14021949
95CLOCK_20551151_ChIP-Seq_293T_Human1.13843741
96P300_19829295_ChIP-Seq_ESCs_Human1.13496121
97KDM2B_26808549_Chip-Seq_K562_Human1.13016093
98SPI1_23127762_ChIP-Seq_K562_Human1.12578935
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.11991020
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11666563
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11088627
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09572203
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09312253
104AHR_22903824_ChIP-Seq_MCF-7_Human1.08848141
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.08682445
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08379002
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08204138
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07632732
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07568657
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.07507010
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07433660
112MAF_26560356_Chip-Seq_TH1_Human1.07262425
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07009404
114AR_25329375_ChIP-Seq_VCAP_Human1.06917980
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06915694
116TCF4_23295773_ChIP-Seq_U87_Human1.06518587
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.06401090
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.06290058
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.06290058
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.06161167
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05798043
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05281259
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04835752
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.04827674
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04051244
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03438518
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01584455
128OCT4_19829295_ChIP-Seq_ESCs_Human1.00133072
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98237382
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.96911469
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96633786
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95816203
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95607877
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95537279
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.94965182
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.94688640
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94520575
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.94484479
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93870984
140* BCOR_27268052_Chip-Seq_Bcells_Human0.93795402
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.93563471
142CTCF_27219007_Chip-Seq_Bcells_Human0.93545307
143UTX_26944678_Chip-Seq_JUKART_Human0.93297982
144TP63_22573176_ChIP-Seq_HFKS_Human0.93282642
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93268851
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92903228
147MAF_26560356_Chip-Seq_TH2_Human0.92722194
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92586778
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91661544
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.90814340
151RUNX2_22187159_ChIP-Seq_PCA_Human0.90620546
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90526352
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90238420
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.89364723
155RNF2_27304074_Chip-Seq_NSC_Mouse0.89070663
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88110943
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88110943
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87113248
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85489593
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84049672
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82654262
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.82061408
163TP53_16413492_ChIP-PET_HCT116_Human0.81206529
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.81101345
165THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79748847
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.79668399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38959941
2MP0003880_abnormal_central_pattern4.62611411
3MP0003635_abnormal_synaptic_transmissio4.09222217
4MP0004270_analgesia3.57620716
5MP0009745_abnormal_behavioral_response3.44984325
6MP0002063_abnormal_learning/memory/cond3.19054793
7MP0002064_seizures3.18355500
8MP0005423_abnormal_somatic_nervous3.04933258
9MP0009046_muscle_twitch2.96741211
10MP0002822_catalepsy2.95659195
11MP0002272_abnormal_nervous_system2.78936237
12MP0003705_abnormal_hypodermis_morpholog2.76879252
13MP0002572_abnormal_emotion/affect_behav2.73715068
14MP0001486_abnormal_startle_reflex2.70294506
15MP0001968_abnormal_touch/_nociception2.64011120
16MP0008260_abnormal_autophagy2.61813286
17MP0002734_abnormal_mechanical_nocicepti2.46864149
18MP0001501_abnormal_sleep_pattern2.33205066
19MP0008569_lethality_at_weaning2.11805782
20MP0005451_abnormal_body_composition2.08916366
21MP0003303_peritoneal_inflammation2.07960553
22MP0004130_abnormal_muscle_cell2.07943636
23MP0001440_abnormal_grooming_behavior2.07114705
24MP0004885_abnormal_endolymph2.02812456
25MP0009780_abnormal_chondrocyte_physiolo1.98943272
26MP0003329_amyloid_beta_deposits1.97698099
27MP0002735_abnormal_chemical_nociception1.94018697
28MP0002736_abnormal_nociception_after1.93452739
29MP0002067_abnormal_sensory_capabilities1.89911870
30MP0003191_abnormal_cellular_cholesterol1.87894070
31MP0001970_abnormal_pain_threshold1.82830026
32MP0003183_abnormal_peptide_metabolism1.80433471
33MP0002733_abnormal_thermal_nociception1.78905884
34MP0005646_abnormal_pituitary_gland1.73144165
35MP0004924_abnormal_behavior1.70508715
36MP0005386_behavior/neurological_phenoty1.70508715
37MP0002557_abnormal_social/conspecific_i1.70055199
38MP0000778_abnormal_nervous_system1.70019695
39MP0005058_abnormal_lysosome_morphology1.64473612
40MP0002909_abnormal_adrenal_gland1.64153071
41MP0005645_abnormal_hypothalamus_physiol1.62971968
42MP0004811_abnormal_neuron_physiology1.61538181
43MP0003436_decreased_susceptibility_to1.60201075
44MP0002184_abnormal_innervation1.59835675
45MP0003787_abnormal_imprinting1.57144690
46MP0000920_abnormal_myelination1.56808851
47MP0001958_emphysema1.56806413
48MP0000955_abnormal_spinal_cord1.56629008
49MP0003300_gastrointestinal_ulcer1.55479158
50MP0004858_abnormal_nervous_system1.48942305
51MP0001502_abnormal_circadian_rhythm1.47602123
52MP0003633_abnormal_nervous_system1.47149431
53MP0002066_abnormal_motor_capabilities/c1.45952764
54MP0002882_abnormal_neuron_morphology1.44359863
55MP0001905_abnormal_dopamine_level1.38115827
56MP0006276_abnormal_autonomic_nervous1.37891360
57MP0003879_abnormal_hair_cell1.37268072
58MP0004142_abnormal_muscle_tone1.36512232
59MP0001529_abnormal_vocalization1.35274485
60MP0001984_abnormal_olfaction1.33309352
61MP0003690_abnormal_glial_cell1.31699593
62MP0009840_abnormal_foam_cell1.28420826
63MP0003631_nervous_system_phenotype1.28222198
64MP0004145_abnormal_muscle_electrophysio1.26853599
65MP0003724_increased_susceptibility_to1.25662985
66MP0002229_neurodegeneration1.24095724
67MP0004742_abnormal_vestibular_system1.23996167
68MP0003566_abnormal_cell_adhesion1.23658077
69MP0000751_myopathy1.21015809
70MP0003045_fibrosis1.20159991
71MP0001348_abnormal_lacrimal_gland1.17193516
72MP0003122_maternal_imprinting1.15942672
73MP0008961_abnormal_basal_metabolism1.11958909
74MP0003091_abnormal_cell_migration1.11949492
75MP0005551_abnormal_eye_electrophysiolog1.11821342
76MP0001849_ear_inflammation1.11444297
77MP0005166_decreased_susceptibility_to1.10373125
78MP0002152_abnormal_brain_morphology1.09756094
79MP0005666_abnormal_adipose_tissue1.09676653
80MP0003279_aneurysm1.07467056
81MP0005464_abnormal_platelet_physiology1.04452365
82MP0005409_darkened_coat_color1.03174852
83MP0003634_abnormal_glial_cell1.03029096
84MP0004043_abnormal_pH_regulation1.02059605
85MP0003632_abnormal_nervous_system1.00966986
86MP0000759_abnormal_skeletal_muscle1.00355577
87MP0002837_dystrophic_cardiac_calcinosis1.00021306
88MP0000013_abnormal_adipose_tissue0.99824558
89MP0000749_muscle_degeneration0.99769821
90MP0001177_atelectasis0.98821382
91MP0004087_abnormal_muscle_fiber0.98443828
92MP0001485_abnormal_pinna_reflex0.98263799
93MP0004947_skin_inflammation0.98120344
94MP0003866_abnormal_defecation0.97786491
95MP0002069_abnormal_eating/drinking_beha0.97507138
96MP0004036_abnormal_muscle_relaxation0.95831430
97MP0008874_decreased_physiological_sensi0.95282569
98MP0005375_adipose_tissue_phenotype0.93819205
99MP0006138_congestive_heart_failure0.93539963
100MP0008872_abnormal_physiological_respon0.93507142
101MP0001963_abnormal_hearing_physiology0.92521312
102MP0005535_abnormal_body_temperature0.92515653
103MP0008438_abnormal_cutaneous_collagen0.91861628
104MP0005076_abnormal_cell_differentiation0.91695626
105MP0010234_abnormal_vibrissa_follicle0.90380913
106MP0004085_abnormal_heartbeat0.90307033
107MP0003656_abnormal_erythrocyte_physiolo0.90269795
108MP0004185_abnormal_adipocyte_glucose0.89413050
109MP0002249_abnormal_larynx_morphology0.89331478
110MP0002971_abnormal_brown_adipose0.89031107
111MP0001533_abnormal_skeleton_physiology0.85872690
112MP0001188_hyperpigmentation0.85312443
113MP0002998_abnormal_bone_remodeling0.85051517
114MP0003283_abnormal_digestive_organ0.82767937
115MP0003075_altered_response_to0.82326569
116MP0000681_abnormal_thyroid_gland0.82098822
117MP0009278_abnormal_bone_marrow0.81428619
118MP0005623_abnormal_meninges_morphology0.80865275
119MP0005083_abnormal_biliary_tract0.80582268
120MP0000604_amyloidosis0.80341631
121MP0000631_abnormal_neuroendocrine_gland0.79356789
122MP0002752_abnormal_somatic_nervous0.79090621
123MP0003137_abnormal_impulse_conducting0.78392037
124MP0010386_abnormal_urinary_bladder0.78378457
125MP0003453_abnormal_keratinocyte_physiol0.75953312
126MP0002090_abnormal_vision0.74681971
127MP0005670_abnormal_white_adipose0.73860173
128MP0003828_pulmonary_edema0.73512172
129MP0001765_abnormal_ion_homeostasis0.72652285
130MP0000678_abnormal_parathyroid_gland0.72370767
131MP0005388_respiratory_system_phenotype0.71562106
132MP0002133_abnormal_respiratory_system0.71562106
133MP0000750_abnormal_muscle_regeneration0.70779569
134MP0002106_abnormal_muscle_physiology0.70472863
135MP0001851_eye_inflammation0.70102523
136MP0010630_abnormal_cardiac_muscle0.69912439
137MP0002089_abnormal_postnatal_growth/wei0.69614584
138MP0005025_abnormal_response_to0.68498443
139MP0002332_abnormal_exercise_endurance0.68038780
140MP0005167_abnormal_blood-brain_barrier0.67472020
141MP0000747_muscle_weakness0.66182409
142MP0003172_abnormal_lysosome_physiology0.65194304
143MP0006072_abnormal_retinal_apoptosis0.64399059
144MP0002638_abnormal_pupillary_reflex0.64171450
145MP0005410_abnormal_fertilization0.64065417
146MP0005499_abnormal_olfactory_system0.62387825
147MP0005394_taste/olfaction_phenotype0.62387825
148MP0004510_myositis0.62037411
149MP0001299_abnormal_eye_distance/0.61896112
150MP0000569_abnormal_digit_pigmentation0.59221734
151MP0004215_abnormal_myocardial_fiber0.58789163
152MP0001664_abnormal_digestion0.58696023
153MP0004484_altered_response_of0.57571122
154MP0001943_abnormal_respiration0.54505312
155MP0010769_abnormal_survival0.53343520
156MP0000003_abnormal_adipose_tissue0.52925606
157MP0010770_preweaning_lethality0.50173235

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.81216027
2Myokymia (HP:0002411)6.57452937
3Focal seizures (HP:0007359)5.40033541
4Visual hallucinations (HP:0002367)4.84524510
5Atonic seizures (HP:0010819)4.35850716
6Epileptic encephalopathy (HP:0200134)4.19251749
7Febrile seizures (HP:0002373)4.15526239
8Obstructive sleep apnea (HP:0002870)4.13477353
9Progressive cerebellar ataxia (HP:0002073)4.09594514
10Supranuclear gaze palsy (HP:0000605)4.08530288
11Ankle clonus (HP:0011448)3.86188980
12Action tremor (HP:0002345)3.85424752
13Absence seizures (HP:0002121)3.66917072
14Generalized tonic-clonic seizures (HP:0002069)3.55439950
15Broad-based gait (HP:0002136)3.52621307
16Abnormality of the corticospinal tract (HP:0002492)3.47563820
17Dysmetria (HP:0001310)3.47035843
18Neurofibrillary tangles (HP:0002185)3.43931325
19Impaired vibration sensation in the lower limbs (HP:0002166)3.41979724
20Dialeptic seizures (HP:0011146)3.40918376
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.36946780
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.36946780
23Dysdiadochokinesis (HP:0002075)3.30777542
24Gaze-evoked nystagmus (HP:0000640)3.24207132
25Urinary bladder sphincter dysfunction (HP:0002839)3.21788821
26Postural instability (HP:0002172)3.20225294
27Depression (HP:0000716)3.18219007
28Spastic gait (HP:0002064)3.14262656
29Cerebral inclusion bodies (HP:0100314)3.09120275
30Poor eye contact (HP:0000817)3.06401888
31Intention tremor (HP:0002080)3.06319062
32Anxiety (HP:0000739)2.98142138
33Abnormal social behavior (HP:0012433)2.91590025
34Impaired social interactions (HP:0000735)2.91590025
35Truncal ataxia (HP:0002078)2.90374894
36Hyperventilation (HP:0002883)2.89027047
37Urinary urgency (HP:0000012)2.88930346
38Increased variability in muscle fiber diameter (HP:0003557)2.81277483
39Exercise-induced myalgia (HP:0003738)2.78338333
40Abnormal eating behavior (HP:0100738)2.77941947
41Increased connective tissue (HP:0009025)2.74327682
42Hyporeflexia of lower limbs (HP:0002600)2.72434631
43Scanning speech (HP:0002168)2.70372672
44Difficulty running (HP:0009046)2.68194920
45Distal lower limb muscle weakness (HP:0009053)2.66314601
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.65474420
47Hemiparesis (HP:0001269)2.63725027
48Genetic anticipation (HP:0003743)2.63656405
49Abnormality of skeletal muscle fiber size (HP:0012084)2.60958411
50Muscle fiber splitting (HP:0003555)2.59493915
51Hemiplegia (HP:0002301)2.58500180
52Eczematoid dermatitis (HP:0000976)2.58174466
53Lower limb muscle weakness (HP:0007340)2.57121831
54Type 1 muscle fiber predominance (HP:0003803)2.55791599
55Amblyopia (HP:0000646)2.55723943
56Drooling (HP:0002307)2.54071504
57Excessive salivation (HP:0003781)2.54071504
58Torticollis (HP:0000473)2.53615055
59Papilledema (HP:0001085)2.52564141
60Cerebral aneurysm (HP:0004944)2.51843557
61Abnormality of the lower motor neuron (HP:0002366)2.48769685
62Myopathic facies (HP:0002058)2.47859580
63Distal lower limb amyotrophy (HP:0008944)2.47352763
64Diplopia (HP:0000651)2.46806575
65Abnormality of binocular vision (HP:0011514)2.46806575
66Impaired smooth pursuit (HP:0007772)2.36434303
67Bradykinesia (HP:0002067)2.35807596
68Impaired vibratory sensation (HP:0002495)2.32796290
69Insomnia (HP:0100785)2.31863952
70Mutism (HP:0002300)2.31597524
71Progressive inability to walk (HP:0002505)2.31279214
72Focal dystonia (HP:0004373)2.31084471
73Termporal pattern (HP:0011008)2.30851802
74Insidious onset (HP:0003587)2.30851802
75Foot dorsiflexor weakness (HP:0009027)2.30204234
76Upper limb amyotrophy (HP:0009129)2.26385887
77Distal upper limb amyotrophy (HP:0007149)2.26385887
78Absent speech (HP:0001344)2.23858526
79Annular pancreas (HP:0001734)2.23543807
80Ventricular fibrillation (HP:0001663)2.21626826
81Stereotypic behavior (HP:0000733)2.21370568
82Increased circulating renin level (HP:0000848)2.18875796
83Slow saccadic eye movements (HP:0000514)2.16771771
84Hypercortisolism (HP:0001578)2.15920691
85Clonus (HP:0002169)2.15637623
86Epileptiform EEG discharges (HP:0011182)2.14704156
87Abnormality of ocular smooth pursuit (HP:0000617)2.11102098
88EEG with generalized epileptiform discharges (HP:0011198)2.09271356
89Abnormality of the foot musculature (HP:0001436)2.08432873
90Craniofacial dystonia (HP:0012179)2.07059646
91Abnormality of saccadic eye movements (HP:0000570)2.05466186
92Megalencephaly (HP:0001355)2.03731624
93Dysmetric saccades (HP:0000641)2.03438178
94Status epilepticus (HP:0002133)2.02914022
95Bundle branch block (HP:0011710)2.01668722
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00700599
97Asymmetric septal hypertrophy (HP:0001670)2.00615755
98Neuronal loss in central nervous system (HP:0002529)2.00526971
99Hypsarrhythmia (HP:0002521)1.99548240
100Protrusio acetabuli (HP:0003179)1.98960895
101Abnormal EKG (HP:0003115)1.98085169
102Lower limb amyotrophy (HP:0007210)1.97598017
103Psychosis (HP:0000709)1.96759299
104Pheochromocytoma (HP:0002666)1.96538362
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95665086
106Prolonged QT interval (HP:0001657)1.95488775
107Peripheral hypomyelination (HP:0007182)1.95380210
108Generalized myoclonic seizures (HP:0002123)1.92981757
109Tetraplegia (HP:0002445)1.92967233
110Agitation (HP:0000713)1.90925552
111Anosmia (HP:0000458)1.88019536
112Blue irides (HP:0000635)1.87911425
113EMG: neuropathic changes (HP:0003445)1.87263054
114Bowel incontinence (HP:0002607)1.87070325
115Polyphagia (HP:0002591)1.86775075
116Sudden death (HP:0001699)1.86735340
117Onion bulb formation (HP:0003383)1.86541868
118Mildly elevated creatine phosphokinase (HP:0008180)1.85996242
119Muscle fiber inclusion bodies (HP:0100299)1.85749147
120Gait ataxia (HP:0002066)1.85263657
121Cellulitis (HP:0100658)1.84753191
122Difficulty climbing stairs (HP:0003551)1.83233051
123Metabolic alkalosis (HP:0200114)1.82838565
124Hyperacusis (HP:0010780)1.82770506
125Rigidity (HP:0002063)1.82503900
126EMG: myopathic abnormalities (HP:0003458)1.82445236
127Rapidly progressive (HP:0003678)1.82215168
128Aplasia involving bones of the extremities (HP:0009825)1.82172667
129Aplasia involving bones of the upper limbs (HP:0009823)1.82172667
130Aplasia of the phalanges of the hand (HP:0009802)1.82172667
131Decreased motor nerve conduction velocity (HP:0003431)1.80534189
132Fetal akinesia sequence (HP:0001989)1.80521370
133Abnormality of salivation (HP:0100755)1.79946160
134Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79887154
135Resting tremor (HP:0002322)1.79732817
136Growth hormone excess (HP:0000845)1.79528118
137Sleep apnea (HP:0010535)1.79494763
138Hand muscle atrophy (HP:0009130)1.79271630
139Stridor (HP:0010307)1.78996273
140Hyperparathyroidism (HP:0000843)1.78924957
141Aneurysm (HP:0002617)1.78600687
142Broad face (HP:0000283)1.77134576
143Nemaline bodies (HP:0003798)1.74630695
144Akinesia (HP:0002304)1.71543105
145Cholecystitis (HP:0001082)1.70063422
146Abnormal gallbladder physiology (HP:0012438)1.70063422
147Spinal canal stenosis (HP:0003416)1.69384321
148Amyloidosis (HP:0011034)1.68458576
149Polycythemia (HP:0001901)1.68297192
150Achilles tendon contracture (HP:0001771)1.68133791
151Abnormal atrioventricular conduction (HP:0005150)1.67741071
152Flat acetabular roof (HP:0003180)1.67301969
153Dysostosis multiplex (HP:0000943)1.67162997
154Vertebral compression fractures (HP:0002953)1.66312262
155Shallow orbits (HP:0000586)1.65808930
156Round ear (HP:0100830)1.64937639
157Hypochromic microcytic anemia (HP:0004840)1.64355769
158Gingivitis (HP:0000230)1.63631276
159Apathy (HP:0000741)1.63350608
160Spontaneous hematomas (HP:0007420)1.63070236
161Ventricular arrhythmia (HP:0004308)1.62178372
162Vascular tortuosity (HP:0004948)1.61147172
163Prolonged bleeding time (HP:0003010)1.60528951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.21816020
2NTRK34.17474749
3TRIB33.23664962
4MAP3K93.17014456
5MAP3K42.51779432
6DAPK22.48158409
7ERN12.47995321
8PRKD32.47326599
9MARK12.41929704
10MINK12.23047783
11NTRK22.22401387
12PAK62.11616181
13MAP2K72.10752170
14TNIK2.08719757
15SIK11.83199784
16NTRK11.80236298
17MAP2K31.70556536
18MAP3K111.68657671
19KSR21.65805854
20PNCK1.62198884
21TTN1.59930924
22CAMKK11.58747301
23CDK51.56915681
24PRPF4B1.56232881
25EPHB11.55710241
26CDK191.55562885
27MAP2K41.54917599
28SIK21.53931645
29MAP3K131.48741803
30UHMK11.48451688
31RIPK41.46669203
32OXSR11.42576519
33STK381.41380970
34MAPK131.40602159
35SGK2231.40020992
36SGK4941.40020992
37SMG11.34702637
38CASK1.33701472
39PRKCH1.33106146
40FES1.30022774
41TYRO31.27241842
42TAOK21.20492314
43EEF2K1.20394863
44STK391.19549086
45PHKG11.18662178
46PHKG21.18662178
47PINK11.14056787
48MAP3K121.13177478
49FGFR41.11517643
50MAP3K31.10162000
51PRKCG1.09980417
52TNK21.08250602
53GRK51.07846871
54MAP3K21.07703532
55GRK61.06953103
56MARK21.06605206
57CAMK11.06149168
58WNK11.02480523
59KSR11.02150838
60TESK11.01728832
61SGK21.01600977
62DAPK11.01434661
63STK110.99491319
64NEK60.99488370
65CAMK2A0.98762312
66SGK30.95763900
67CAMK1G0.93224873
68MAP3K70.93130578
69PLK20.92841032
70CAMK2B0.92131611
71PKN20.89149490
72MAP4K10.88512232
73BMPR20.88389525
74PKN10.87948715
75ZAP700.83609309
76DYRK1B0.83119948
77ARAF0.81922923
78RPS6KA20.80907045
79HIPK20.80889731
80PTK2B0.80790740
81CDK150.80642195
82PAK30.79163463
83SGK10.78963388
84TAOK10.78882226
85CDK180.78526098
86DYRK1A0.76802276
87PTK60.76249166
88CDK120.74398953
89PDK10.74065360
90LMTK20.73594752
91ALK0.73279552
92PDPK10.72828600
93CDK140.72636303
94CDC42BPA0.72336630
95SIK30.70954532
96CDK11A0.70510384
97LATS20.70206388
98PDGFRA0.67683140
99WNK40.67230521
100PRKG20.67174935
101JAK10.66066278
102JAK20.65770640
103BLK0.65501081
104MAP3K60.65466648
105TYK20.65247371
106IRAK20.64468032
107CAMK2D0.63615109
108MAP3K10.63609651
109RET0.63387931
110ICK0.62534091
111BMX0.62080223
112CSK0.61409501
113MAPKAPK50.61068202
114PRKD20.60528526
115FGR0.59954079
116FGFR20.59779193
117CSNK1G20.58951893
118FYN0.57946345
119MAPK70.57801690
120FGFR30.56842651
121CAMK40.56750409
122PRKCE0.56705301
123ROCK20.56027783
124IRAK40.55447709
125HCK0.54946896
126RPS6KA30.54002681
127CAMKK20.53852109
128RIPK10.53383420
129DMPK0.53334308
130CAMK2G0.52793524
131TBK10.51506640
132PRKCZ0.50578262
133OBSCN0.49730914
134MAP2K60.49535209
135MAPK100.48945788
136PTK20.46893290
137MTOR0.46314924
138INSRR0.46087692
139MAP2K20.45435309
140MAPK120.40477340
141PRKCQ0.37785742
142PRKCB0.37343857
143PRKD10.37077465
144RAF10.36713101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46645171
2Synaptic vesicle cycle_Homo sapiens_hsa047212.86615209
3Olfactory transduction_Homo sapiens_hsa047402.79777631
4GABAergic synapse_Homo sapiens_hsa047272.71065688
5Circadian entrainment_Homo sapiens_hsa047132.66107374
6Glutamatergic synapse_Homo sapiens_hsa047242.61458100
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57070812
8Morphine addiction_Homo sapiens_hsa050322.55589824
9Long-term potentiation_Homo sapiens_hsa047202.51583953
10Amphetamine addiction_Homo sapiens_hsa050312.39811955
11Salivary secretion_Homo sapiens_hsa049702.17483343
12Dopaminergic synapse_Homo sapiens_hsa047282.05804358
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05395859
14Insulin secretion_Homo sapiens_hsa049112.03124103
15Gastric acid secretion_Homo sapiens_hsa049711.98637571
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91747641
17Cholinergic synapse_Homo sapiens_hsa047251.88721897
18Taste transduction_Homo sapiens_hsa047421.79723191
19Cocaine addiction_Homo sapiens_hsa050301.69333370
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66705628
21Renin secretion_Homo sapiens_hsa049241.65865873
22Calcium signaling pathway_Homo sapiens_hsa040201.60574676
23Serotonergic synapse_Homo sapiens_hsa047261.59730957
24Long-term depression_Homo sapiens_hsa047301.58709713
25Oxytocin signaling pathway_Homo sapiens_hsa049211.58382959
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51442972
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35975547
28Nitrogen metabolism_Homo sapiens_hsa009101.35856482
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34812097
30GnRH signaling pathway_Homo sapiens_hsa049121.33668800
31cAMP signaling pathway_Homo sapiens_hsa040241.31633857
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27365014
33Type II diabetes mellitus_Homo sapiens_hsa049301.26966757
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25395345
35Acute myeloid leukemia_Homo sapiens_hsa052211.18560513
36Gap junction_Homo sapiens_hsa045401.17741976
37Collecting duct acid secretion_Homo sapiens_hsa049661.15248914
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14649596
39Axon guidance_Homo sapiens_hsa043601.11216975
40B cell receptor signaling pathway_Homo sapiens_hsa046621.09644589
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07653214
42Chronic myeloid leukemia_Homo sapiens_hsa052201.07196017
43Estrogen signaling pathway_Homo sapiens_hsa049151.06711010
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02903361
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.02770464
46Phototransduction_Homo sapiens_hsa047441.01662802
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01397725
48Osteoclast differentiation_Homo sapiens_hsa043801.00603315
49ErbB signaling pathway_Homo sapiens_hsa040120.96715329
50Cardiac muscle contraction_Homo sapiens_hsa042600.96402343
51Melanogenesis_Homo sapiens_hsa049160.95897380
52Pancreatic secretion_Homo sapiens_hsa049720.95722898
53Glioma_Homo sapiens_hsa052140.95608898
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92815081
55Notch signaling pathway_Homo sapiens_hsa043300.92477871
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.92167157
57Dorso-ventral axis formation_Homo sapiens_hsa043200.91703060
58AMPK signaling pathway_Homo sapiens_hsa041520.89653753
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.88421869
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87923019
61Dilated cardiomyopathy_Homo sapiens_hsa054140.84938845
62Thyroid hormone synthesis_Homo sapiens_hsa049180.84605424
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83930167
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.83812437
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79944069
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79912309
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79890393
68Other glycan degradation_Homo sapiens_hsa005110.79545556
69Platelet activation_Homo sapiens_hsa046110.78624324
70Pancreatic cancer_Homo sapiens_hsa052120.76084646
71Amoebiasis_Homo sapiens_hsa051460.75852063
72Prolactin signaling pathway_Homo sapiens_hsa049170.75683305
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75564587
74Choline metabolism in cancer_Homo sapiens_hsa052310.74535459
75MAPK signaling pathway_Homo sapiens_hsa040100.74163569
76Vibrio cholerae infection_Homo sapiens_hsa051100.71141382
77Insulin resistance_Homo sapiens_hsa049310.70116910
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69182573
79Focal adhesion_Homo sapiens_hsa045100.68926053
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.65986557
81Hepatitis C_Homo sapiens_hsa051600.65891196
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65709636
83T cell receptor signaling pathway_Homo sapiens_hsa046600.65364811
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65167779
85Tuberculosis_Homo sapiens_hsa051520.64205420
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64171043
87Bile secretion_Homo sapiens_hsa049760.64017464
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63516855
89Oocyte meiosis_Homo sapiens_hsa041140.61927071
90Ras signaling pathway_Homo sapiens_hsa040140.60764983
91Inositol phosphate metabolism_Homo sapiens_hsa005620.60404572
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60235730
93HIF-1 signaling pathway_Homo sapiens_hsa040660.58572690
94Glucagon signaling pathway_Homo sapiens_hsa049220.57576780
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56189513
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54514665
97Arginine biosynthesis_Homo sapiens_hsa002200.54268329
98Leishmaniasis_Homo sapiens_hsa051400.53838589
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51703899
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51366985
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.50696636
102Rap1 signaling pathway_Homo sapiens_hsa040150.49460048
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.48855725
104VEGF signaling pathway_Homo sapiens_hsa043700.48381037
105Endocytosis_Homo sapiens_hsa041440.48378411
106Ovarian steroidogenesis_Homo sapiens_hsa049130.47941242
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47876352
108Prion diseases_Homo sapiens_hsa050200.47393357
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45567481
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45016410
111Alcoholism_Homo sapiens_hsa050340.44514476
112Circadian rhythm_Homo sapiens_hsa047100.43872250
113Chemokine signaling pathway_Homo sapiens_hsa040620.40662580
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39754731
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39729295
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39588181
117Type I diabetes mellitus_Homo sapiens_hsa049400.38996580
118Renal cell carcinoma_Homo sapiens_hsa052110.38790167
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.38745150
120Wnt signaling pathway_Homo sapiens_hsa043100.37390303
121Insulin signaling pathway_Homo sapiens_hsa049100.35377154
122Non-small cell lung cancer_Homo sapiens_hsa052230.34545653
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33963150
124Fatty acid biosynthesis_Homo sapiens_hsa000610.33229205
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33030120
126Butanoate metabolism_Homo sapiens_hsa006500.30975107
127mTOR signaling pathway_Homo sapiens_hsa041500.27345030
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26144089
129Alzheimers disease_Homo sapiens_hsa050100.25715671
130African trypanosomiasis_Homo sapiens_hsa051430.23533256
131Endometrial cancer_Homo sapiens_hsa052130.23138975

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