ZFAND2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein refolding (GO:0042026)7.88928658
2negative regulation of inclusion body assembly (GO:0090084)7.37640974
3chaperone mediated protein folding requiring cofactor (GO:0051085)7.31919016
4regulation of female gonad development (GO:2000194)6.63465874
5regulation of acrosome reaction (GO:0060046)6.41866968
6multicellular organism reproduction (GO:0032504)6.09325301
7regulation of meiosis I (GO:0060631)5.70864063
8piRNA metabolic process (GO:0034587)5.35358146
9meiotic cell cycle (GO:0051321)5.09113402
10retinal cone cell development (GO:0046549)5.00757214
11relaxation of smooth muscle (GO:0044557)4.82749045
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.77344006
13regulation of inclusion body assembly (GO:0090083)4.54549729
14protein localization to endosome (GO:0036010)4.46954383
15regulation of early endosome to late endosome transport (GO:2000641)4.46450765
16regulation of clathrin-mediated endocytosis (GO:2000369)4.42286390
17negative regulation of reproductive process (GO:2000242)4.30505391
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30089517
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30089517
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.30089517
21modulation by symbiont of host immune response (GO:0052553)4.30089517
22positive regulation by symbiont of host defense response (GO:0052509)4.30089517
23modulation by symbiont of host defense response (GO:0052031)4.30089517
24regulation of DNA methylation (GO:0044030)4.14242497
25proteasome assembly (GO:0043248)4.08242674
26neuron fate determination (GO:0048664)4.07710067
27oocyte development (GO:0048599)4.02411535
28viral protein processing (GO:0019082)4.01791258
29positive regulation of humoral immune response (GO:0002922)3.96021303
30regulation of hypersensitivity (GO:0002883)3.94391579
31DNA methylation involved in gamete generation (GO:0043046)3.93685432
32reproduction (GO:0000003)3.74938141
33synaptic vesicle maturation (GO:0016188)3.74176727
34negative regulation of cAMP-mediated signaling (GO:0043951)3.72294652
35positive regulation of macroautophagy (GO:0016239)3.66475693
36pyrimidine dimer repair (GO:0006290)3.59700894
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57891490
38positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.57845543
39female gamete generation (GO:0007292)3.57150132
40centriole replication (GO:0007099)3.50282299
41dopamine biosynthetic process (GO:0042416)3.42037668
42binding of sperm to zona pellucida (GO:0007339)3.41512301
43regulation of steroid hormone secretion (GO:2000831)3.35352209
44meiosis I (GO:0007127)3.33469555
45sulfation (GO:0051923)3.32232723
46male meiosis I (GO:0007141)3.31289565
47vitamin transmembrane transport (GO:0035461)3.28616042
48autophagic vacuole assembly (GO:0000045)3.23252293
49negative regulation of striated muscle cell apoptotic process (GO:0010664)3.22118839
50macrophage activation involved in immune response (GO:0002281)3.21236856
51proline transport (GO:0015824)3.20246161
52glycine transport (GO:0015816)3.15358757
53regulation of cell maturation (GO:1903429)3.15214793
54regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.14665662
55sperm-egg recognition (GO:0035036)3.14125454
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12268830
57platelet dense granule organization (GO:0060155)3.10536273
58negative regulation of macroautophagy (GO:0016242)3.09275635
59cell adhesion mediated by integrin (GO:0033627)3.06963197
60layer formation in cerebral cortex (GO:0021819)3.06898497
61stress fiber assembly (GO:0043149)3.04275144
62L-amino acid import (GO:0043092)3.01892302
63primitive streak formation (GO:0090009)3.01856644
64macroautophagy (GO:0016236)3.00195040
65regulation of MHC class I biosynthetic process (GO:0045343)2.97085674
66cellular biogenic amine catabolic process (GO:0042402)2.92719441
67amine catabolic process (GO:0009310)2.92719441
68male meiosis (GO:0007140)2.92328587
69regulation of interferon-beta biosynthetic process (GO:0045357)2.92290848
70protein neddylation (GO:0045116)2.92221597
71positive regulation of autophagy (GO:0010508)2.87892817
72apoptotic cell clearance (GO:0043277)2.87784761
73glutamate secretion (GO:0014047)2.87069419
74regulation of translational termination (GO:0006449)2.86968116
75synaptic vesicle exocytosis (GO:0016079)2.86778448
76sodium ion export (GO:0071436)2.85085038
77protein kinase C signaling (GO:0070528)2.85076539
78negative regulation of smooth muscle contraction (GO:0045986)2.84812663
79regulation of ARF protein signal transduction (GO:0032012)2.84251194
80single fertilization (GO:0007338)2.83603505
81cullin deneddylation (GO:0010388)2.82674930
82negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.78889287
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77783664
84negative regulation of cell killing (GO:0031342)2.77783664
85protein deneddylation (GO:0000338)2.75994818
86positive regulation of gastrulation (GO:2000543)2.75389500
87labyrinthine layer development (GO:0060711)2.75316565
88ER overload response (GO:0006983)2.74789669
89positive regulation of T cell apoptotic process (GO:0070234)2.73788384
90positive regulation of meiosis (GO:0045836)2.71799717
91positive regulation of histone H3-K4 methylation (GO:0051571)2.71334872
92cellular response to nerve growth factor stimulus (GO:1990090)2.68396445
93response to nerve growth factor (GO:1990089)2.68396445
94regulation of retinoic acid receptor signaling pathway (GO:0048385)2.67874779
95artery smooth muscle contraction (GO:0014824)2.66732532
96positive regulation of meiotic cell cycle (GO:0051446)2.66295496
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65871550
98histone H2A ubiquitination (GO:0033522)2.65390802
99clathrin coat assembly (GO:0048268)2.65131444
100transferrin transport (GO:0033572)2.64073079
101regulation of immunoglobulin secretion (GO:0051023)2.63502722
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62664509
103L-phenylalanine metabolic process (GO:0006558)2.62664509
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61967645
105sexual reproduction (GO:0019953)2.61173827
106negative regulation of muscle cell apoptotic process (GO:0010656)2.60432442
107neuromuscular process controlling balance (GO:0050885)2.60152119
108fertilization (GO:0009566)2.59551801
109regulation of synaptic vesicle exocytosis (GO:2000300)2.58973932
110locomotory exploration behavior (GO:0035641)2.58364076
111glycosylceramide metabolic process (GO:0006677)2.57888048
112chaperone-mediated protein complex assembly (GO:0051131)2.57003568
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56638140
114positive regulation of uterine smooth muscle contraction (GO:0070474)2.56251523
115synapsis (GO:0007129)2.55857914
116amino acid import (GO:0043090)2.54585424
117cellular potassium ion homeostasis (GO:0030007)2.54430367
118regulation of meiosis (GO:0040020)2.53982803
119cochlea development (GO:0090102)2.53746603
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53607835
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.53072147
122CDP-diacylglycerol metabolic process (GO:0046341)2.52919903
123cell migration in hindbrain (GO:0021535)2.52887674
124respiratory electron transport chain (GO:0022904)2.50959374
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50433964
126nerve growth factor signaling pathway (GO:0038180)2.49272532
127energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48809128
128ATP synthesis coupled proton transport (GO:0015986)2.48809128
129intestinal epithelial cell development (GO:0060576)2.47910416
130electron transport chain (GO:0022900)2.47556542
131triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.47421655
132cellular response to zinc ion (GO:0071294)2.46515945
133cellular response to thyroid hormone stimulus (GO:0097067)2.46283697
134organelle membrane fusion (GO:0090174)2.45265573
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.45059600
136regulation of calcium ion-dependent exocytosis (GO:0017158)2.44150878
137alanine transport (GO:0032328)2.42675245
138response to host immune response (GO:0052572)2.42387430
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42387430
140regulation of histone H3-K9 methylation (GO:0051570)2.41567334
141virion assembly (GO:0019068)2.40711765
142positive regulation of steroid hormone secretion (GO:2000833)2.40426292
143regulation of synapse structural plasticity (GO:0051823)2.40424570
144trivalent inorganic cation transport (GO:0072512)2.40206331
145ferric iron transport (GO:0015682)2.40206331
146polyamine biosynthetic process (GO:0006596)2.39675906
147positive regulation of ATP catabolic process (GO:1903291)2.39609557
148positive regulation of ATPase activity (GO:0032781)2.39609557
149positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.39320912
150regulation of integrin activation (GO:0033623)2.39113814
151regulation of phospholipid biosynthetic process (GO:0071071)2.38465032
152regulation of catecholamine metabolic process (GO:0042069)2.36259279
153regulation of dopamine metabolic process (GO:0042053)2.36259279
154positive regulation of lymphocyte apoptotic process (GO:0070230)2.35934948
155regulation of macroautophagy (GO:0016241)2.35933009
156fibroblast migration (GO:0010761)2.35775039
157tonic smooth muscle contraction (GO:0014820)2.35447571
158NLS-bearing protein import into nucleus (GO:0006607)2.34858747
159neuromuscular process controlling posture (GO:0050884)2.34348477
160citrulline biosynthetic process (GO:0019240)2.33865904
161cell-cell recognition (GO:0009988)2.33781214
162negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.33236265
163activation of protein kinase A activity (GO:0034199)2.32914119
164neuron cell-cell adhesion (GO:0007158)2.32653722
165vesicle transport along microtubule (GO:0047496)2.32551325
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32367791
167response to host (GO:0075136)2.32367791
168response to host defenses (GO:0052200)2.32367791
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.32308502
170histone mRNA catabolic process (GO:0071044)2.31918400
171regulation of norepinephrine secretion (GO:0014061)2.31552144
172phosphorelay signal transduction system (GO:0000160)2.31324199
173labyrinthine layer blood vessel development (GO:0060716)2.30961934
174regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30121629
175positive regulation of leukocyte apoptotic process (GO:2000108)2.27616152
176positive regulation of fibroblast migration (GO:0010763)2.27276777
177negative regulation of NF-kappaB import into nucleus (GO:0042347)2.25717364
178regulation of nucleobase-containing compound transport (GO:0032239)2.25282292
179localization within membrane (GO:0051668)2.24824308
180plasma membrane repair (GO:0001778)2.24204594
181regulation of integrin-mediated signaling pathway (GO:2001044)2.22737679
182positive regulation of bone resorption (GO:0045780)2.22696947
183positive regulation of bone remodeling (GO:0046852)2.22696947
184regulation of NFAT protein import into nucleus (GO:0051532)2.20338279
185synaptic vesicle docking involved in exocytosis (GO:0016081)2.17488823
186positive regulation of macrophage cytokine production (GO:0060907)2.14915628
187protein targeting to plasma membrane (GO:0072661)2.14560233
188phagosome maturation (GO:0090382)2.14544608
189dendrite morphogenesis (GO:0048813)2.14469492
190response to lipoprotein particle (GO:0055094)2.14186421
191positive regulation of response to nutrient levels (GO:0032109)2.13236186
192positive regulation of response to extracellular stimulus (GO:0032106)2.13236186
193regulation of ARF GTPase activity (GO:0032312)2.12102923
194microglial cell activation (GO:0001774)2.11325509
195modulation by symbiont of host cellular process (GO:0044068)2.10957922
196positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.10825547
197regulation of synaptic vesicle transport (GO:1902803)2.10779663
198regulation of mononuclear cell migration (GO:0071675)2.10337070
199regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10021021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.61047989
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.38911290
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.95370009
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.88524711
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.40238688
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23428599
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.17860554
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.14149326
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08446379
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03839545
11ZNF263_19887448_ChIP-Seq_K562_Human2.87103990
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.80213835
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.66910220
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.58281847
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48171754
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41011345
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33913260
18KDM2B_26808549_Chip-Seq_K562_Human2.33909359
19TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.25369630
20KDM2B_26808549_Chip-Seq_DND41_Human2.13406826
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12170734
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10025710
23P300_27058665_Chip-Seq_ZR-75-30cells_Human2.09127684
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08388666
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03930638
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.98948385
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98068887
28GBX2_23144817_ChIP-Seq_PC3_Human1.96938057
29ATF3_27146783_Chip-Seq_COLON_Human1.96381762
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95006876
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93334496
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89348326
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89348326
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89348326
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.87431712
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86194122
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82614736
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81714315
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.80762279
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.76833374
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74802080
42VDR_23849224_ChIP-Seq_CD4+_Human1.72246622
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71386237
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70914229
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.66303803
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.66223751
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.66154646
48ELK1_19687146_ChIP-ChIP_HELA_Human1.65245739
49IRF1_19129219_ChIP-ChIP_H3396_Human1.63536064
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63221050
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61444347
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.60348482
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60239637
54TCF7_22412390_ChIP-Seq_EML_Mouse1.58885223
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.57598005
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.57263529
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55959344
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54838460
59RACK7_27058665_Chip-Seq_MCF-7_Human1.54681068
60* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54600364
61FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.53420238
62ZNF274_21170338_ChIP-Seq_K562_Hela1.51212531
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50733178
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.50283076
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48673023
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47458906
67MYC_18940864_ChIP-ChIP_HL60_Human1.46753186
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44181780
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.43138639
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42551953
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41955911
72* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41307534
73VDR_22108803_ChIP-Seq_LS180_Human1.41071719
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.39924268
75* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39897887
76CLOCK_20551151_ChIP-Seq_293T_Human1.39711191
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39638235
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38053576
79RXR_22108803_ChIP-Seq_LS180_Human1.37874966
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37847987
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34455408
82* SPI1_23127762_ChIP-Seq_K562_Human1.34377166
83AR_25329375_ChIP-Seq_VCAP_Human1.34202088
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32158147
85* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31854818
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.31618964
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29963639
88* MITF_21258399_ChIP-Seq_MELANOMA_Human1.29103626
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29102289
90TFEB_21752829_ChIP-Seq_HELA_Human1.29014397
91HTT_18923047_ChIP-ChIP_STHdh_Human1.28498869
92TP53_22573176_ChIP-Seq_HFKS_Human1.27496432
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27059259
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26343632
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26127030
96EWS_26573619_Chip-Seq_HEK293_Human1.25424146
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24731396
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24552357
99* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22885020
100CREB1_26743006_Chip-Seq_LNCaP_Human1.22810830
101FOXP3_21729870_ChIP-Seq_TREG_Human1.21980916
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21873656
103MYC_22102868_ChIP-Seq_BL_Human1.21602366
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21262185
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.21093592
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20455049
107* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20234997
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19448438
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18594349
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18272134
111LXR_22292898_ChIP-Seq_THP-1_Human1.18225634
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18011449
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17760820
114SALL4_22934838_ChIP-ChIP_CD34+_Human1.17202261
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17126755
116CBP_20019798_ChIP-Seq_JUKART_Human1.17126755
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17100079
118* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16858403
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16779821
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15835142
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15427097
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.15027605
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14309134
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14217654
125GATA3_21878914_ChIP-Seq_MCF-7_Human1.12916156
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12522857
127AR_20517297_ChIP-Seq_VCAP_Human1.12506213
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12245833
129* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11471751
130KLF5_25053715_ChIP-Seq_YYC3_Human1.11198221
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11190259
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09488815
133ELK1_22589737_ChIP-Seq_MCF10A_Human1.09448814
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08885689
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08874224
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08784207
137* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08666590
138POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08248492
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07828879
140EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07748441
141SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07497656
142CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07139596
143FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06822834
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.06822834
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06722558
146NANOG_19829295_ChIP-Seq_ESCs_Human1.06592830
147SOX2_19829295_ChIP-Seq_ESCs_Human1.06592830
148PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06271815
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04737198
150FOXH1_21741376_ChIP-Seq_EPCs_Human1.03689949
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03689758
152ER_23166858_ChIP-Seq_MCF-7_Human1.03623425
153SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03296987
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02855157
155GATA2_21666600_ChIP-Seq_HMVEC_Human1.02589125
156HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02556152
157GATA1_19941826_ChIP-Seq_K562_Human1.01525003
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01461201
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00404576
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99573883
161VDR_24787735_ChIP-Seq_THP-1_Human0.99501694
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.99264985
163CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98742360
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98636310
165FOXM1_23109430_ChIP-Seq_U2OS_Human0.98531868
166BCAT_22108803_ChIP-Seq_LS180_Human0.97892924
167NANOG_20526341_ChIP-Seq_ESCs_Human0.96490851
168P300_19829295_ChIP-Seq_ESCs_Human0.95223478
169MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94036983
170MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88411315
171RNF2_27304074_Chip-Seq_NSC_Mouse0.84710968
172CDX2_22108803_ChIP-Seq_LS180_Human0.84242464
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84002533
174TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84002533
175PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83506411
176FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83473009
177TAL1_26923725_Chip-Seq_HPCs_Mouse0.82792617
178ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82592400
179DCP1A_22483619_ChIP-Seq_HELA_Human0.82306404
180TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82108912
181CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81442373
182ERG_20517297_ChIP-Seq_VCAP_Human0.81439092
183SMAD4_21741376_ChIP-Seq_EPCs_Human0.79166438
184TCF4_22108803_ChIP-Seq_LS180_Human0.74503294
185PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72665909
186EZH2_27294783_Chip-Seq_NPCs_Mouse0.72508020
187GATA6_21074721_ChIP-Seq_CACO-2_Human0.71016392
188SMRT_27268052_Chip-Seq_Bcells_Human0.70949218
189SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.70555558
190OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70372075
191BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70098271
192SRF_21415370_ChIP-Seq_HL-1_Mouse0.69829651
193LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69446406
194SMAD4_21799915_ChIP-Seq_A2780_Human0.68881131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.10497634
2MP0005058_abnormal_lysosome_morphology4.07090708
3MP0002139_abnormal_hepatobiliary_system3.98852507
4MP0003172_abnormal_lysosome_physiology3.41822163
5MP0009840_abnormal_foam_cell3.32381388
6MP0003806_abnormal_nucleotide_metabolis3.28835700
7MP0003303_peritoneal_inflammation3.17663959
8MP0008877_abnormal_DNA_methylation2.95115822
9MP0003950_abnormal_plasma_membrane2.91573760
10MP0004510_myositis2.83557513
11MP0000569_abnormal_digit_pigmentation2.68728423
12MP0005410_abnormal_fertilization2.62303175
13MP0008789_abnormal_olfactory_epithelium2.61811690
14MP0003195_calcinosis2.54033277
15MP0004858_abnormal_nervous_system2.49694092
16MP0005257_abnormal_intraocular_pressure2.48171800
17MP0010307_abnormal_tumor_latency2.27177281
18MP0008260_abnormal_autophagy2.24759278
19MP0003136_yellow_coat_color2.23101059
20MP0000604_amyloidosis2.22715783
21MP0002138_abnormal_hepatobiliary_system2.16775009
22MP0005394_taste/olfaction_phenotype2.16685909
23MP0005499_abnormal_olfactory_system2.16685909
24MP0004270_analgesia2.13224848
25MP0008961_abnormal_basal_metabolism2.12070540
26MP0006292_abnormal_olfactory_placode2.07912886
27MP0003705_abnormal_hypodermis_morpholog2.06577250
28MP0006082_CNS_inflammation2.05263124
29MP0005076_abnormal_cell_differentiation2.02535837
30MP0008058_abnormal_DNA_repair2.01750661
31MP0009278_abnormal_bone_marrow1.91367572
32MP0003329_amyloid_beta_deposits1.89193101
33MP0003690_abnormal_glial_cell1.86051212
34MP0003091_abnormal_cell_migration1.82888710
35MP0005395_other_phenotype1.82813454
36MP0002148_abnormal_hypersensitivity_rea1.81526191
37MP0005646_abnormal_pituitary_gland1.81088620
38MP0009046_muscle_twitch1.78384637
39MP0001929_abnormal_gametogenesis1.76536836
40MP0001986_abnormal_taste_sensitivity1.75131928
41MP0002160_abnormal_reproductive_system1.68430138
42MP0003635_abnormal_synaptic_transmissio1.68263813
43MP0008875_abnormal_xenobiotic_pharmacok1.67813508
44MP0003634_abnormal_glial_cell1.66148350
45MP0003448_altered_tumor_morphology1.65973233
46MP0002064_seizures1.65318557
47MP0004185_abnormal_adipocyte_glucose1.63045114
48MP0003699_abnormal_female_reproductive1.62296609
49MP0003880_abnormal_central_pattern1.59115863
50MP0005464_abnormal_platelet_physiology1.57515147
51MP0005085_abnormal_gallbladder_physiolo1.57468241
52MP0003075_altered_response_to1.56181524
53MP0005310_abnormal_salivary_gland1.55409732
54MP0002277_abnormal_respiratory_mucosa1.55169366
55MP0010352_gastrointestinal_tract_polyps1.54993717
56MP0003191_abnormal_cellular_cholesterol1.54465828
57MP0003890_abnormal_embryonic-extraembry1.52387046
58MP0005360_urolithiasis1.51709375
59MP0003186_abnormal_redox_activity1.51283660
60MP0002877_abnormal_melanocyte_morpholog1.50469299
61MP0008004_abnormal_stomach_pH1.49458301
62MP0004142_abnormal_muscle_tone1.47254342
63MP0005389_reproductive_system_phenotype1.44542636
64MP0001905_abnormal_dopamine_level1.43524146
65MP0002210_abnormal_sex_determination1.43454077
66MP0002736_abnormal_nociception_after1.35645699
67MP0005551_abnormal_eye_electrophysiolog1.34579634
68MP0002132_abnormal_respiratory_system1.33915944
69MP0001501_abnormal_sleep_pattern1.31596387
70MP0003566_abnormal_cell_adhesion1.30741353
71MP0002272_abnormal_nervous_system1.30538606
72MP0001764_abnormal_homeostasis1.27666445
73MP0005084_abnormal_gallbladder_morpholo1.27662160
74MP0006276_abnormal_autonomic_nervous1.27541336
75MP0002063_abnormal_learning/memory/cond1.26696244
76MP0005423_abnormal_somatic_nervous1.25602234
77MP0002909_abnormal_adrenal_gland1.24602858
78MP0002090_abnormal_vision1.24216699
79MP0006036_abnormal_mitochondrial_physio1.23227171
80MP0005623_abnormal_meninges_morphology1.23200574
81MP0009764_decreased_sensitivity_to1.23165509
82MP0002734_abnormal_mechanical_nocicepti1.22113226
83MP0003300_gastrointestinal_ulcer1.21124971
84MP0000747_muscle_weakness1.20903671
85MP0001299_abnormal_eye_distance/1.20437622
86MP0004811_abnormal_neuron_physiology1.17944465
87MP0001440_abnormal_grooming_behavior1.15942002
88MP0004742_abnormal_vestibular_system1.15617122
89MP0000733_abnormal_muscle_development1.15532674
90MP0003828_pulmonary_edema1.14096322
91MP0000653_abnormal_sex_gland1.14021906
92MP0002161_abnormal_fertility/fecundity1.13747811
93MP0003436_decreased_susceptibility_to1.13122525
94MP0005167_abnormal_blood-brain_barrier1.12661041
95MP0009785_altered_susceptibility_to1.11639070
96MP0001324_abnormal_eye_pigmentation1.09288420
97MP0001545_abnormal_hematopoietic_system1.09008372
98MP0005397_hematopoietic_system_phenotyp1.09008372
99MP0003183_abnormal_peptide_metabolism1.08980814
100MP0001119_abnormal_female_reproductive1.07858853
101MP0003868_abnormal_feces_composition1.07816904
102MP0002998_abnormal_bone_remodeling1.07436537
103MP0000750_abnormal_muscle_regeneration1.07384979
104MP0001849_ear_inflammation1.07086226
105MP0002733_abnormal_thermal_nociception1.06356540
106* MP0005621_abnormal_cell_physiology1.05405302
107MP0001970_abnormal_pain_threshold1.05014063
108MP0005647_abnormal_sex_gland1.04607355
109MP0000631_abnormal_neuroendocrine_gland1.03909434
110MP0000003_abnormal_adipose_tissue1.02986133
111MP0004885_abnormal_endolymph1.02666976
112MP0003453_abnormal_keratinocyte_physiol1.02447898
113MP0004130_abnormal_muscle_cell1.02368909
114MP0001502_abnormal_circadian_rhythm1.02293672
115MP0005164_abnormal_response_to1.02180917
116MP0009697_abnormal_copulation1.02044709
117MP0000920_abnormal_myelination1.01593456
118MP0002095_abnormal_skin_pigmentation1.01098748
119MP0001533_abnormal_skeleton_physiology1.00326200
120MP0004947_skin_inflammation0.98157491
121MP0001919_abnormal_reproductive_system0.97751823
122MP0000372_irregular_coat_pigmentation0.97045825
123MP0000013_abnormal_adipose_tissue0.96889487
124MP0000762_abnormal_tongue_morphology0.96020169
125MP0003656_abnormal_erythrocyte_physiolo0.95868760
126MP0005166_decreased_susceptibility_to0.95123663
127MP0000015_abnormal_ear_pigmentation0.94170459
128MP0001666_abnormal_nutrient_absorption0.93654235
129MP0001851_eye_inflammation0.92628185
130MP0009780_abnormal_chondrocyte_physiolo0.92597700
131MP0002419_abnormal_innate_immunity0.92533013
132MP0000230_abnormal_systemic_arterial0.91895645
133MP0003698_abnormal_male_reproductive0.91650330
134MP0003879_abnormal_hair_cell0.88951411
135MP0001879_abnormal_lymphatic_vessel0.88761304
136MP0003633_abnormal_nervous_system0.88356710
137MP0002572_abnormal_emotion/affect_behav0.88234605
138MP0001968_abnormal_touch/_nociception0.84984804
139MP0004019_abnormal_vitamin_homeostasis0.84426205
140MP0009333_abnormal_splenocyte_physiolog0.83118830
141MP0005451_abnormal_body_composition0.82001457
142MP0002928_abnormal_bile_duct0.81828806
143MP0003632_abnormal_nervous_system0.81763296
144MP0000343_altered_response_to0.81019537
145MP0001984_abnormal_olfaction0.80027873
146MP0008007_abnormal_cellular_replicative0.79963512
147MP0010234_abnormal_vibrissa_follicle0.79063432
148MP0010678_abnormal_skin_adnexa0.78328395
149MP0003724_increased_susceptibility_to0.77503237
150MP0001756_abnormal_urination0.76914491
151MP0003252_abnormal_bile_duct0.76185288
152MP0004233_abnormal_muscle_weight0.75337919
153MP0010368_abnormal_lymphatic_system0.75269579
154* MP0005384_cellular_phenotype0.74832300
155MP0001145_abnormal_male_reproductive0.74765354
156MP0006035_abnormal_mitochondrial_morpho0.74762580
157MP0003631_nervous_system_phenotype0.74403190
158MP0003045_fibrosis0.74322802
159MP0001881_abnormal_mammary_gland0.73673808
160MP0002653_abnormal_ependyma_morphology0.73533636
161MP0000627_abnormal_mammary_gland0.72426043
162MP0008872_abnormal_physiological_respon0.72206589
163MP0002638_abnormal_pupillary_reflex0.71080848
164MP0000350_abnormal_cell_proliferation0.69481840
165MP0002723_abnormal_immune_serum0.69119575
166MP0005332_abnormal_amino_acid0.68964605
167MP0005365_abnormal_bile_salt0.68688053
168MP0003221_abnormal_cardiomyocyte_apopto0.68476657
169MP0003638_abnormal_response/metabolism_0.68033874
170MP0003718_maternal_effect0.67977251
171MP0000647_abnormal_sebaceous_gland0.67169319
172MP0002184_abnormal_innervation0.66755128
173MP0009745_abnormal_behavioral_response0.66636159
174MP0001486_abnormal_startle_reflex0.65870934
175MP0000955_abnormal_spinal_cord0.65551769
176MP0005023_abnormal_wound_healing0.65364677
177MP0000858_altered_metastatic_potential0.63899478
178MP0004147_increased_porphyrin_level0.63723568
179MP0005375_adipose_tissue_phenotype0.63607237
180MP0003953_abnormal_hormone_level0.62875185
181MP0002735_abnormal_chemical_nociception0.62794313
182MP0005174_abnormal_tail_pigmentation0.61408370

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.09289588
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.38223785
3Abnormality of liposaccharide metabolism (HP:0010968)4.09878579
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.09878579
5Abnormality of glycolipid metabolism (HP:0010969)4.09878579
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.00266205
7Acute necrotizing encephalopathy (HP:0006965)3.66240867
8Mutism (HP:0002300)3.61141535
9Supernumerary spleens (HP:0009799)3.51154636
10Global brain atrophy (HP:0002283)3.44029764
11Diaphragmatic weakness (HP:0009113)3.43368376
12Dysostosis multiplex (HP:0000943)3.29401050
13Abnormal mitochondria in muscle tissue (HP:0008316)3.20092169
14Septo-optic dysplasia (HP:0100842)3.17514827
15Segmental peripheral demyelination/remyelination (HP:0003481)3.15902136
16Renal Fanconi syndrome (HP:0001994)3.15485621
17Progressive macrocephaly (HP:0004481)3.14914266
18Supranuclear gaze palsy (HP:0000605)3.14420635
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.01838189
20Hypoplasia of the fovea (HP:0007750)3.01838189
21Acute encephalopathy (HP:0006846)2.99666670
223-Methylglutaconic aciduria (HP:0003535)2.99526129
23Abnormal gallbladder physiology (HP:0012438)2.99235901
24Cholecystitis (HP:0001082)2.99235901
25Axonal loss (HP:0003447)2.98812216
26Mitochondrial inheritance (HP:0001427)2.97751398
27Absent septum pellucidum (HP:0001331)2.87603552
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.86814626
29Oligodactyly (hands) (HP:0001180)2.84586658
30Disinhibition (HP:0000734)2.77627392
31Nausea (HP:0002018)2.73942390
32Neuronal loss in central nervous system (HP:0002529)2.69925473
33Visual hallucinations (HP:0002367)2.69552222
34Upper limb amyotrophy (HP:0009129)2.69060230
35Distal upper limb amyotrophy (HP:0007149)2.69060230
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68324259
37Abnormality of polysaccharide metabolism (HP:0011012)2.68324259
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68324259
39Generalized aminoaciduria (HP:0002909)2.68291790
40Spastic tetraparesis (HP:0001285)2.68153850
41Apathy (HP:0000741)2.67849017
42Mucopolysacchariduria (HP:0008155)2.67359551
43Urinary glycosaminoglycan excretion (HP:0003541)2.67359551
44Increased CSF lactate (HP:0002490)2.66620978
45Nuclear cataract (HP:0100018)2.65161623
46Hypophosphatemic rickets (HP:0004912)2.57013487
47Hand muscle atrophy (HP:0009130)2.53859105
48Abnormality of the fovea (HP:0000493)2.51096275
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.47118925
50Diminished motivation (HP:0000745)2.46779462
51Neurofibrillary tangles (HP:0002185)2.45403535
52Median cleft lip (HP:0000161)2.44832847
53Cerebral aneurysm (HP:0004944)2.44419763
54Cerebral inclusion bodies (HP:0100314)2.43230626
55Premature rupture of membranes (HP:0001788)2.42412783
56Achilles tendon contracture (HP:0001771)2.42388811
57Abnormality of renal resorption (HP:0011038)2.40392726
58Focal seizures (HP:0007359)2.39457978
59Hyperlipoproteinemia (HP:0010980)2.36802714
60Genu recurvatum (HP:0002816)2.35366234
61Focal motor seizures (HP:0011153)2.34119188
62Vacuolated lymphocytes (HP:0001922)2.31402789
63Hypokinesia (HP:0002375)2.30988465
64Azoospermia (HP:0000027)2.30982786
65Action tremor (HP:0002345)2.30310712
66Myokymia (HP:0002411)2.24178680
67Peripheral demyelination (HP:0011096)2.23760036
68Increased hepatocellular lipid droplets (HP:0006565)2.23315681
69Infertility (HP:0000789)2.21708510
70Insidious onset (HP:0003587)2.20163794
71Termporal pattern (HP:0011008)2.20163794
72Difficulty climbing stairs (HP:0003551)2.19854035
73Malnutrition (HP:0004395)2.18940208
74Rhinitis (HP:0012384)2.18815139
75Anterior segment dysgenesis (HP:0007700)2.16847016
76Abnormality of macrophages (HP:0004311)2.16209994
77Personality changes (HP:0000751)2.15940036
78Aplastic anemia (HP:0001915)2.15567664
79Dialeptic seizures (HP:0011146)2.14017443
80Loss of speech (HP:0002371)2.12143466
81Hepatic necrosis (HP:0002605)2.11981095
82Exertional dyspnea (HP:0002875)2.11512621
83Genetic anticipation (HP:0003743)2.11391638
84Myocardial infarction (HP:0001658)2.11029841
85Abnormality of the septum pellucidum (HP:0007375)2.10897604
86Clumsiness (HP:0002312)2.09268587
87Bundle branch block (HP:0011710)2.09071633
88Entropion (HP:0000621)2.08639153
89Short tibia (HP:0005736)2.08603629
90Abnormal ciliary motility (HP:0012262)2.08341079
91Petechiae (HP:0000967)2.07934402
92Rapidly progressive (HP:0003678)2.07745481
93Abnormality of the lower motor neuron (HP:0002366)2.07687981
94Osteomalacia (HP:0002749)2.07188790
95Hepatocellular necrosis (HP:0001404)2.06899147
96Cerebral edema (HP:0002181)2.06648015
97Upper motor neuron abnormality (HP:0002127)2.06435364
98Abnormality of lateral ventricle (HP:0030047)2.05945247
99Absence seizures (HP:0002121)2.05548255
100Stomatitis (HP:0010280)2.05439175
101Abnormality of the Achilles tendon (HP:0005109)2.04794092
102Congenital, generalized hypertrichosis (HP:0004540)2.04361140
103Atonic seizures (HP:0010819)2.03269347
104Hypoplasia of the uterus (HP:0000013)2.02910831
105True hermaphroditism (HP:0010459)2.02505672
106Hypothermia (HP:0002045)2.02299142
107Medial flaring of the eyebrow (HP:0010747)2.01896159
108Increased CSF protein (HP:0002922)1.98241458
109Onion bulb formation (HP:0003383)1.97798316
110Facial hemangioma (HP:0000329)1.97747943
111Degeneration of anterior horn cells (HP:0002398)1.96206923
112Abnormality of the anterior horn cell (HP:0006802)1.96206923
113Oligodactyly (HP:0012165)1.95754286
114Fair hair (HP:0002286)1.95703471
115Pancreatic cysts (HP:0001737)1.95245204
116Inappropriate behavior (HP:0000719)1.94486895
117Ulnar claw (HP:0001178)1.94460311
118Male infertility (HP:0003251)1.93327288
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.91726122
120Abnormal spermatogenesis (HP:0008669)1.91484770
121Cervical subluxation (HP:0003308)1.89713712
122Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89610283
123Parakeratosis (HP:0001036)1.86654722
124Nephrogenic diabetes insipidus (HP:0009806)1.86615726
125Febrile seizures (HP:0002373)1.86282273
126Prolonged neonatal jaundice (HP:0006579)1.85644472
127Lipid accumulation in hepatocytes (HP:0006561)1.85150653
128Horizontal nystagmus (HP:0000666)1.85009412
129Purpura (HP:0000979)1.84932375
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.83745210
131Osteolytic defects of the hand bones (HP:0009699)1.83745210
132Spinal muscular atrophy (HP:0007269)1.83289632
133Optic disc pallor (HP:0000543)1.82979757
134Aplasia/hypoplasia of the uterus (HP:0008684)1.82439677
135Decreased central vision (HP:0007663)1.81228355
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80513336
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80513336
138Conjugated hyperbilirubinemia (HP:0002908)1.80002592
139X-linked dominant inheritance (HP:0001423)1.79561388
140Oral leukoplakia (HP:0002745)1.79383899
141Abnormal respiratory motile cilium physiology (HP:0012261)1.79324494
142Steatorrhea (HP:0002570)1.79284509
143Recurrent abscess formation (HP:0002722)1.79115076
144Type II lissencephaly (HP:0007260)1.78807489
145Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78592781
146Conjunctival telangiectasia (HP:0000524)1.78173124
147Abnormality of midbrain morphology (HP:0002418)1.77576291
148Molar tooth sign on MRI (HP:0002419)1.77576291
149Short nail (HP:0001799)1.75504513
150Lactic acidosis (HP:0003128)1.74806795
151Renal tubular dysfunction (HP:0000124)1.74499462
152Intellectual disability, profound (HP:0002187)1.73605452
153Shallow orbits (HP:0000586)1.73347972
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72896661
155Abnormality of alanine metabolism (HP:0010916)1.72896661
156Hyperalaninemia (HP:0003348)1.72896661
157Abnormality of the periventricular white matter (HP:0002518)1.71509600
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.71312353
159Pustule (HP:0200039)1.71076498
160Tetraplegia (HP:0002445)1.71036157
161Glycosuria (HP:0003076)1.70060888
162Abnormality of urine glucose concentration (HP:0011016)1.70060888
163Oligodontia (HP:0000677)1.68856432
164Ulnar bowing (HP:0003031)1.68815207
165Abnormality of the motor neurons (HP:0002450)1.67782384
166Abnormal neuron morphology (HP:0012757)1.67782384
167Ovoid vertebral bodies (HP:0003300)1.67699620
168Arterial tortuosity (HP:0005116)1.65522773
169Distal sensory impairment (HP:0002936)1.64579184
170Urinary bladder sphincter dysfunction (HP:0002839)1.64427660
171Recurrent bacterial skin infections (HP:0005406)1.63768762
172Peripheral hypomyelination (HP:0007182)1.63735867
173Excessive salivation (HP:0003781)1.63515877
174Drooling (HP:0002307)1.63515877
175Ankle clonus (HP:0011448)1.62276296
176Asymmetric septal hypertrophy (HP:0001670)1.62201730
177Generalized tonic-clonic seizures (HP:0002069)1.61632219
178Postural tremor (HP:0002174)1.60982662
179Cupped ribs (HP:0000887)1.59937713
180Submucous cleft hard palate (HP:0000176)1.59729420
181Diplopia (HP:0000651)1.59310284
182Abnormality of binocular vision (HP:0011514)1.59310284
183Eczematoid dermatitis (HP:0000976)1.57931059
184Retinal atrophy (HP:0001105)1.57538888
185Alopecia of scalp (HP:0002293)1.57343331
186Abnormality of the odontoid process (HP:0003310)1.56970043
187Slow saccadic eye movements (HP:0000514)1.56948006
188Atrioventricular block (HP:0001678)1.56342137
189Progressive cerebellar ataxia (HP:0002073)1.56114214
190Abnormality of the corticospinal tract (HP:0002492)1.55886830
191Polycythemia (HP:0001901)1.55455770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.38291518
2LATS23.54926485
3MAPKAPK53.45182939
4MAPK153.09623057
5TRIB33.00848340
6KSR22.72474672
7TAOK12.66584684
8WEE12.61440965
9PAK62.59759390
10SCYL22.48275493
11MST42.28898871
12EPHA21.94881945
13DDR21.92202740
14NTRK11.85547683
15BMPR21.78343587
16CDK121.75007525
17ALK1.74726990
18TYRO31.71939139
19VRK11.70669095
20CAMKK11.68649269
21MAPKAPK31.67100750
22EIF2AK31.66299049
23BRAF1.63922283
24MOS1.61520425
25STK381.57966157
26NEK61.57561131
27MAP3K121.54760620
28PRKD31.52232745
29CAMKK21.49174469
30STK241.48615679
31LATS11.47327411
32RIPK41.43183083
33FGR1.42020643
34MAP3K21.39832616
35TRIM281.38908088
36DMPK1.36778896
37BMX1.36271605
38ARAF1.36178236
39BCKDK1.35653228
40ABL21.35632921
41SIK21.31753047
42GRK51.30819528
43MARK11.27669052
44NTRK31.26124479
45MAP3K61.25990661
46IKBKB1.20117310
47NUAK11.17832789
48ZAK1.17468967
49ADRBK21.13587429
50MARK31.10084580
51RIPK11.10042874
52PRKCI1.09001818
53PTK21.08164320
54IRAK11.05772780
55IRAK31.05630158
56EIF2AK11.03024956
57STK31.01891045
58CSNK1G21.00066945
59RET0.98800980
60MAP3K30.97589689
61BMPR1B0.97232786
62MINK10.96684829
63KSR10.94659795
64ERN10.93394311
65GRK70.92861141
66PAK30.92103950
67PDGFRB0.90427281
68AURKA0.90023567
69RAF10.89560304
70TLK10.88705074
71MAP3K110.88326200
72MAP3K40.87986586
73PDGFRA0.87903501
74CAMK1G0.87636892
75CAMK1D0.87167054
76EPHA40.86496528
77DAPK20.85960999
78PIM10.84105833
79PNCK0.82551286
80PRKCH0.82364861
81MARK20.82120731
82MAP3K50.81727346
83MAP2K10.80947589
84EPHB10.80879421
85MYLK0.80750711
86CDK50.78807809
87CDK90.78567180
88NEK20.78056711
89MTOR0.77020515
90CDK30.75787003
91MAP2K40.74514067
92MAPK130.74456455
93PIM20.74073788
94TBK10.73413261
95ILK0.71951650
96SIK30.71492559
97NEK10.70614372
98STK160.70495744
99NTRK20.70098132
100MAPK100.69957966
101PLK20.69365800
102MATK0.66135049
103PDPK10.66035213
104MAP3K10.65914218
105MAP3K130.65770515
106GRK10.65482364
107PKN10.64841588
108MET0.63193838
109CSNK1A1L0.62759283
110STK100.62682657
111STK110.61452596
112ICK0.61261323
113AKT30.60752136
114PLK30.60494294
115TAOK30.59214738
116CDK60.58977602
117PRKG10.57192230
118CDK80.57008043
119MAP4K20.55436011
120IKBKE0.55063502
121CHUK0.54189344
122ABL10.52961264
123ERBB40.52412474
124STK38L0.52376413
125TSSK60.52338447
126PHKG10.52012764
127PHKG20.52012764
128GSK3A0.51773322
129PDK10.50603643
130RPS6KA40.50496397
131PAK10.49522595
132STK390.49470103
133CSNK1G30.49122667
134PINK10.49121486
135DYRK30.48421896
136TNK20.48217600
137PAK20.48182763
138EGFR0.47046373
139CSNK1G10.46892930
140PAK40.46718289
141CDK140.46581007
142PDK20.46139314
143CASK0.46077908
144INSRR0.45954092
145MAP2K20.45944192
146IRAK20.45913381
147PRKCG0.45305363
148MAP2K70.45185861
149BRSK10.45088539
150TIE10.44796963
151JAK10.44473344
152CAMK2A0.43702984
153LMTK20.43435154
154TTN0.42894949
155VRK20.42805642
156TAOK20.41094020
157TESK20.41007246
158PTK2B0.38497355
159SGK30.38098232
160EPHB20.36458344
161CAMK2G0.36138035
162NME20.34235482
163WNK40.32450532
164IRAK40.28603758
165TESK10.27861616
166RPS6KA50.27753504
167LIMK10.27747482
168LYN0.26423770
169PRKACA0.26263116

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.56356167
2Protein export_Homo sapiens_hsa030603.50218188
3Proteasome_Homo sapiens_hsa030503.41995828
4Parkinsons disease_Homo sapiens_hsa050122.99187515
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81293243
6Legionellosis_Homo sapiens_hsa051342.78148485
7Basal transcription factors_Homo sapiens_hsa030222.74260768
8Lysosome_Homo sapiens_hsa041422.43739852
9Folate biosynthesis_Homo sapiens_hsa007902.28188223
10Vitamin B6 metabolism_Homo sapiens_hsa007502.21996815
11Synaptic vesicle cycle_Homo sapiens_hsa047212.17198832
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03812759
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.02119702
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99810784
15Huntingtons disease_Homo sapiens_hsa050161.96889092
16Caffeine metabolism_Homo sapiens_hsa002321.86769646
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84926130
18mTOR signaling pathway_Homo sapiens_hsa041501.78194448
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.69190626
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66296445
21Ovarian steroidogenesis_Homo sapiens_hsa049131.62276237
22Ribosome_Homo sapiens_hsa030101.60607195
23Alzheimers disease_Homo sapiens_hsa050101.59328626
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.53964825
25Dorso-ventral axis formation_Homo sapiens_hsa043201.52722470
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52288215
27Collecting duct acid secretion_Homo sapiens_hsa049661.51133113
28Renal cell carcinoma_Homo sapiens_hsa052111.48541929
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47092914
30RNA polymerase_Homo sapiens_hsa030201.45255744
31Olfactory transduction_Homo sapiens_hsa047401.44873994
32RNA degradation_Homo sapiens_hsa030181.43391311
33Phototransduction_Homo sapiens_hsa047441.38050114
34Sulfur metabolism_Homo sapiens_hsa009201.37599769
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34577037
36Glioma_Homo sapiens_hsa052141.33838437
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33704580
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30951842
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29978773
40Tuberculosis_Homo sapiens_hsa051521.29187726
41Regulation of autophagy_Homo sapiens_hsa041401.28787084
42Phagosome_Homo sapiens_hsa041451.27589899
43VEGF signaling pathway_Homo sapiens_hsa043701.27576156
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.25409882
45Endocytosis_Homo sapiens_hsa041441.24448002
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.21960954
47Osteoclast differentiation_Homo sapiens_hsa043801.20442616
48GnRH signaling pathway_Homo sapiens_hsa049121.19015130
49Estrogen signaling pathway_Homo sapiens_hsa049151.18218791
50Rheumatoid arthritis_Homo sapiens_hsa053231.17513168
51Antigen processing and presentation_Homo sapiens_hsa046121.17032109
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16063263
53Long-term potentiation_Homo sapiens_hsa047201.14239465
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13004293
55Chronic myeloid leukemia_Homo sapiens_hsa052201.11803862
56ErbB signaling pathway_Homo sapiens_hsa040121.11304259
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10954872
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09032051
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08286360
60Pancreatic cancer_Homo sapiens_hsa052121.08230583
61Fatty acid elongation_Homo sapiens_hsa000621.08001936
62Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07966184
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07337834
64Oocyte meiosis_Homo sapiens_hsa041141.05527333
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04178644
66Nitrogen metabolism_Homo sapiens_hsa009101.02900901
67Phospholipase D signaling pathway_Homo sapiens_hsa040721.01792518
68Sphingolipid signaling pathway_Homo sapiens_hsa040711.01253803
69Shigellosis_Homo sapiens_hsa051311.00537376
70Choline metabolism in cancer_Homo sapiens_hsa052310.99945231
71Complement and coagulation cascades_Homo sapiens_hsa046100.97917077
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96799549
73Influenza A_Homo sapiens_hsa051640.94506379
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94442829
75Gap junction_Homo sapiens_hsa045400.93851442
76Chemical carcinogenesis_Homo sapiens_hsa052040.93832626
77Proteoglycans in cancer_Homo sapiens_hsa052050.93547431
78GABAergic synapse_Homo sapiens_hsa047270.92361404
79Nucleotide excision repair_Homo sapiens_hsa034200.91922770
80MAPK signaling pathway_Homo sapiens_hsa040100.90965149
81Cardiac muscle contraction_Homo sapiens_hsa042600.90917522
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.90506500
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.90390541
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90139997
85Type II diabetes mellitus_Homo sapiens_hsa049300.87794510
86Colorectal cancer_Homo sapiens_hsa052100.87778439
87Circadian rhythm_Homo sapiens_hsa047100.87299409
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85837117
89Vibrio cholerae infection_Homo sapiens_hsa051100.85794443
90Salivary secretion_Homo sapiens_hsa049700.85489116
91Fanconi anemia pathway_Homo sapiens_hsa034600.85335278
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85277011
93Sulfur relay system_Homo sapiens_hsa041220.85234319
94Cholinergic synapse_Homo sapiens_hsa047250.84279514
95Apoptosis_Homo sapiens_hsa042100.83984710
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83780681
97Glutamatergic synapse_Homo sapiens_hsa047240.83749356
98Endometrial cancer_Homo sapiens_hsa052130.81904732
99B cell receptor signaling pathway_Homo sapiens_hsa046620.81821584
100p53 signaling pathway_Homo sapiens_hsa041150.81743990
101Long-term depression_Homo sapiens_hsa047300.81451967
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81266851
103FoxO signaling pathway_Homo sapiens_hsa040680.81074099
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.80545484
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79597574
106Gastric acid secretion_Homo sapiens_hsa049710.78974788
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78641752
108Dopaminergic synapse_Homo sapiens_hsa047280.78469424
109Leishmaniasis_Homo sapiens_hsa051400.77724448
110Oxytocin signaling pathway_Homo sapiens_hsa049210.77629701
111Linoleic acid metabolism_Homo sapiens_hsa005910.77462349
112Amphetamine addiction_Homo sapiens_hsa050310.77332983
113Salmonella infection_Homo sapiens_hsa051320.76623866
114Non-small cell lung cancer_Homo sapiens_hsa052230.76422603
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76120806
116Spliceosome_Homo sapiens_hsa030400.75984912
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75835663
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75476678
119Amoebiasis_Homo sapiens_hsa051460.74573403
120Glutathione metabolism_Homo sapiens_hsa004800.74547760
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73285697
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73218903
123Circadian entrainment_Homo sapiens_hsa047130.72405715
124Prolactin signaling pathway_Homo sapiens_hsa049170.72228486
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.72161438
126Cocaine addiction_Homo sapiens_hsa050300.72038400
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71827185
128Homologous recombination_Homo sapiens_hsa034400.71640657
129MicroRNAs in cancer_Homo sapiens_hsa052060.71281503
130Arachidonic acid metabolism_Homo sapiens_hsa005900.71154507
131Nicotine addiction_Homo sapiens_hsa050330.70850279
132Mismatch repair_Homo sapiens_hsa034300.70636164
133Asthma_Homo sapiens_hsa053100.70258740
134Bladder cancer_Homo sapiens_hsa052190.70228866
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70041414
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69591597
137Pertussis_Homo sapiens_hsa051330.69169846
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68730818
139Rap1 signaling pathway_Homo sapiens_hsa040150.68208239
140Hepatitis B_Homo sapiens_hsa051610.67887403
141TNF signaling pathway_Homo sapiens_hsa046680.67877104
142Mineral absorption_Homo sapiens_hsa049780.67723977
143Chemokine signaling pathway_Homo sapiens_hsa040620.66067167
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66041818
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.65266981
146Cell cycle_Homo sapiens_hsa041100.64918763
147Sphingolipid metabolism_Homo sapiens_hsa006000.64904253
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64245133
149Toxoplasmosis_Homo sapiens_hsa051450.63987570
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.63780960
151Morphine addiction_Homo sapiens_hsa050320.63130599
152Ras signaling pathway_Homo sapiens_hsa040140.62816783
153Focal adhesion_Homo sapiens_hsa045100.62644108
154Prion diseases_Homo sapiens_hsa050200.61708818
155HIF-1 signaling pathway_Homo sapiens_hsa040660.61197643
156Inositol phosphate metabolism_Homo sapiens_hsa005620.61181160
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61030836
158cAMP signaling pathway_Homo sapiens_hsa040240.59921996
159Adherens junction_Homo sapiens_hsa045200.58443278
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58041716
161Taste transduction_Homo sapiens_hsa047420.55875958
162Staphylococcus aureus infection_Homo sapiens_hsa051500.54466495
163Steroid biosynthesis_Homo sapiens_hsa001000.54185599
164Bile secretion_Homo sapiens_hsa049760.48152471
165Purine metabolism_Homo sapiens_hsa002300.48108712
166Epstein-Barr virus infection_Homo sapiens_hsa051690.45512933
167Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39618255
168alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37527587
169Hematopoietic cell lineage_Homo sapiens_hsa046400.36824334
170Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36151134
171Metabolic pathways_Homo sapiens_hsa011000.35768389
172RNA transport_Homo sapiens_hsa030130.34286526
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33748754
174Pyrimidine metabolism_Homo sapiens_hsa002400.33184103
175ABC transporters_Homo sapiens_hsa020100.29842530
176RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29740141
177Measles_Homo sapiens_hsa051620.26478051

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