ZFAND2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.82926367
2ribosomal small subunit assembly (GO:0000028)4.66192967
3antigen processing and presentation of endogenous antigen (GO:0019883)4.58740846
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51035731
5positive regulation of gamma-delta T cell activation (GO:0046645)4.38194896
6DNA deamination (GO:0045006)4.18168618
7neutrophil activation involved in immune response (GO:0002283)4.16370627
8negative regulation of cell killing (GO:0031342)4.13852520
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.13852520
10immunoglobulin mediated immune response (GO:0016064)3.80863724
11positive regulation of B cell differentiation (GO:0045579)3.63834033
12regulation of B cell receptor signaling pathway (GO:0050855)3.60669958
13proteasome assembly (GO:0043248)3.47476915
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.35504118
15L-phenylalanine metabolic process (GO:0006558)3.35504118
16response to interferon-beta (GO:0035456)3.30395553
17detection of bacterium (GO:0016045)3.28267438
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25638140
19L-phenylalanine catabolic process (GO:0006559)3.25638140
20L-methionine salvage (GO:0071267)3.16170237
21L-methionine biosynthetic process (GO:0071265)3.16170237
22amino acid salvage (GO:0043102)3.16170237
23neutrophil activation (GO:0042119)3.15408203
24detection of other organism (GO:0098543)3.14322005
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14082728
26regulation of B cell differentiation (GO:0045577)3.13392552
27aromatic amino acid family catabolic process (GO:0009074)3.13094811
28regulation of cellular amino acid metabolic process (GO:0006521)3.10789505
29regulation of gamma-delta T cell differentiation (GO:0045586)3.09875069
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07834449
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06605258
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06571182
33regulation of B cell apoptotic process (GO:0002902)3.06552767
34purine deoxyribonucleotide catabolic process (GO:0009155)3.06209255
35actin nucleation (GO:0045010)3.01679831
36viral transcription (GO:0019083)3.01022736
37positive thymic T cell selection (GO:0045059)3.00872223
38regulation of mast cell degranulation (GO:0043304)3.00415565
39negative regulation of B cell apoptotic process (GO:0002903)2.99589584
40glycine metabolic process (GO:0006544)2.98595272
41autophagic vacuole fusion (GO:0000046)2.97481816
42tolerance induction (GO:0002507)2.97441951
43ribosomal small subunit biogenesis (GO:0042274)2.96508280
44positive regulation of antigen processing and presentation (GO:0002579)2.96346129
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96224859
46maturation of SSU-rRNA (GO:0030490)2.96050716
47folic acid metabolic process (GO:0046655)2.95920091
48tryptophan catabolic process (GO:0006569)2.95294659
49indole-containing compound catabolic process (GO:0042436)2.95294659
50indolalkylamine catabolic process (GO:0046218)2.95294659
51organelle membrane fusion (GO:0090174)2.94635707
52B cell receptor signaling pathway (GO:0050853)2.94459884
53regulation of gamma-delta T cell activation (GO:0046643)2.93891172
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93305267
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92071886
56heme biosynthetic process (GO:0006783)2.89109598
57translational termination (GO:0006415)2.88873181
58purine nucleobase biosynthetic process (GO:0009113)2.88044451
59leukocyte degranulation (GO:0043299)2.87259501
60granulocyte activation (GO:0036230)2.87159321
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86916569
62nucleoside salvage (GO:0043174)2.86225633
63positive regulation of T cell differentiation in thymus (GO:0033089)2.85835612
64negative regulation of erythrocyte differentiation (GO:0045647)2.85415096
65B cell mediated immunity (GO:0019724)2.84476950
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84120743
67peptidyl-histidine modification (GO:0018202)2.83824109
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82767988
69sulfur amino acid catabolic process (GO:0000098)2.82668432
70respiratory chain complex IV assembly (GO:0008535)2.81697371
71formation of translation preinitiation complex (GO:0001731)2.80869835
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79665630
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79665630
74regulation of mast cell activation (GO:0033003)2.79619803
75response to peptidoglycan (GO:0032494)2.79258082
76aldehyde catabolic process (GO:0046185)2.78757949
77regulation of antigen processing and presentation (GO:0002577)2.78553185
78modulation by symbiont of host defense response (GO:0052031)2.78251757
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78251757
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78251757
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.78251757
82modulation by symbiont of host immune response (GO:0052553)2.78251757
83positive regulation by symbiont of host defense response (GO:0052509)2.78251757
84regulation of germinal center formation (GO:0002634)2.77985158
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77932561
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77932561
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77932561
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76152363
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75978834
90negative regulation of ligase activity (GO:0051352)2.75656376
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75656376
92cellular metabolic compound salvage (GO:0043094)2.75413337
93cotranslational protein targeting to membrane (GO:0006613)2.75048240
94heme metabolic process (GO:0042168)2.74834251
95ribosomal large subunit biogenesis (GO:0042273)2.72942984
96antigen processing and presentation via MHC class Ib (GO:0002475)2.72848716
97protein targeting to ER (GO:0045047)2.72671279
98tryptophan metabolic process (GO:0006568)2.71943503
99translational elongation (GO:0006414)2.71812102
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71205996
101mature B cell differentiation involved in immune response (GO:0002313)2.71155592
102protoporphyrinogen IX biosynthetic process (GO:0006782)2.71037412
103negative regulation of innate immune response (GO:0045824)2.70096011
104positive regulation of granulocyte differentiation (GO:0030854)2.69711196
105cellular response to type I interferon (GO:0071357)2.69037027
106type I interferon signaling pathway (GO:0060337)2.69037027
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68612714
108regulation of mast cell activation involved in immune response (GO:0033006)2.68441179
109defense response to protozoan (GO:0042832)2.68165240
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.68058853
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67673519
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.67673519
113nucleobase biosynthetic process (GO:0046112)2.67373154
114protein localization to endoplasmic reticulum (GO:0070972)2.67170026
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67066475
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66736645
117negative T cell selection (GO:0043383)2.66551644
118chaperone-mediated protein transport (GO:0072321)2.66482391
119serine family amino acid biosynthetic process (GO:0009070)2.66021441
120protoporphyrinogen IX metabolic process (GO:0046501)2.65866071
121negative thymic T cell selection (GO:0045060)2.65824160
122response to type I interferon (GO:0034340)2.65449836
123termination of RNA polymerase III transcription (GO:0006386)2.65030991
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.65030991
125cysteine metabolic process (GO:0006534)2.64660003
126serine family amino acid catabolic process (GO:0009071)2.64069848
127positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63708434
128sulfur amino acid biosynthetic process (GO:0000097)2.62325602
129purine nucleotide salvage (GO:0032261)2.60442878
130negative regulation of leukocyte mediated immunity (GO:0002704)2.59918159
131mucosal-associated lymphoid tissue development (GO:0048537)2.59785217
132Peyers patch development (GO:0048541)2.59785217
133regulation of T cell mediated cytotoxicity (GO:0001914)2.59412768
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58688813
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.58688813
136NADH dehydrogenase complex assembly (GO:0010257)2.58688813
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.58261779
138kynurenine metabolic process (GO:0070189)2.58173528
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58001317
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58001317
141cytidine deamination (GO:0009972)2.56728586
142cytidine metabolic process (GO:0046087)2.56728586
143cytidine catabolic process (GO:0006216)2.56728586
144cytochrome complex assembly (GO:0017004)2.54622049
145protein complex biogenesis (GO:0070271)2.54588591
146oxidative phosphorylation (GO:0006119)2.54569365
147S-adenosylmethionine metabolic process (GO:0046500)2.53770065
148fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.53725027
149antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.53703556
150thrombin receptor signaling pathway (GO:0070493)2.53700327
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53521064
152negative regulation of T-helper cell differentiation (GO:0045623)2.53521064
153glyoxylate metabolic process (GO:0046487)2.53316737
154establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53218210
155serine family amino acid metabolic process (GO:0009069)2.52938111
156regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52660936
157aromatic amino acid family metabolic process (GO:0009072)2.51722283
158response to protozoan (GO:0001562)2.51390249
159purine-containing compound salvage (GO:0043101)2.51295138
160respiratory burst (GO:0045730)2.50969729
161methionine metabolic process (GO:0006555)2.50964840
162response to interleukin-15 (GO:0070672)2.50559174
163lysine metabolic process (GO:0006553)2.48654689
164lysine catabolic process (GO:0006554)2.48654689
165positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47836400
166translational initiation (GO:0006413)2.47541435
167GDP-mannose metabolic process (GO:0019673)2.47355701
168regulation of regulatory T cell differentiation (GO:0045589)2.46978933
169myeloid cell activation involved in immune response (GO:0002275)2.46381740
170lipoxygenase pathway (GO:0019372)2.46180165
171high-density lipoprotein particle remodeling (GO:0034375)2.45825323
172translation (GO:0006412)2.45567042
173negative regulation of glycoprotein biosynthetic process (GO:0010561)2.45432402
174interferon-gamma-mediated signaling pathway (GO:0060333)2.45351634
175urea cycle (GO:0000050)2.44942682
176urea metabolic process (GO:0019627)2.44942682
177sequestering of actin monomers (GO:0042989)2.44836411
178iron-sulfur cluster assembly (GO:0016226)2.44681809
179metallo-sulfur cluster assembly (GO:0031163)2.44681809
180leukocyte aggregation (GO:0070486)2.44523518
181megakaryocyte development (GO:0035855)2.44056523
182regulation of leukocyte degranulation (GO:0043300)2.43246045
183response to host immune response (GO:0052572)2.41784346
184response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41784346
185positive T cell selection (GO:0043368)2.38892549
186deoxyribonucleotide catabolic process (GO:0009264)2.38057714
187mast cell activation (GO:0045576)2.37223375
188cellular response to interferon-beta (GO:0035458)2.36646974
189negative regulation of T cell apoptotic process (GO:0070233)2.36207641
190purinergic nucleotide receptor signaling pathway (GO:0035590)2.36196187
191negative regulation of lymphocyte apoptotic process (GO:0070229)2.35909309
192actin filament polymerization (GO:0030041)2.35000506
193regulation of granulocyte differentiation (GO:0030852)2.33734097
194positive regulation of T cell migration (GO:2000406)2.32256511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.35375995
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59307243
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.54398458
4E2F7_22180533_ChIP-Seq_HELA_Human3.12845502
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09494569
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06901747
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.93339147
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.81427660
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78181952
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.68974299
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66017724
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.63561520
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.58603514
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53996049
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52439477
16* RXR_22158963_ChIP-Seq_LIVER_Mouse2.36006927
17SCL_19346495_ChIP-Seq_HPC-7_Human2.34327785
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30605711
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30122873
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29395063
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28491884
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24933737
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21787319
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12305878
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08882683
26* VDR_23849224_ChIP-Seq_CD4+_Human2.07274730
27UTX_26944678_Chip-Seq_JUKART_Human2.02173967
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00225534
29* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.98981335
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98887252
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98313620
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.95868494
33MYB_26560356_Chip-Seq_TH2_Human1.94583728
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.94484507
35VDR_24763502_ChIP-Seq_THP-1_Human1.90671941
36* BCL6_27268052_Chip-Seq_Bcells_Human1.87369798
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86010199
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83745854
39DCP1A_22483619_ChIP-Seq_HELA_Human1.83285564
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83002982
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81352070
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80848500
43FOXP3_21729870_ChIP-Seq_TREG_Human1.80257682
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78591612
45XRN2_22483619_ChIP-Seq_HELA_Human1.78582909
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77304435
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76404807
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75133737
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74869017
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.74440097
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74097732
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.73966318
53BCOR_27268052_Chip-Seq_Bcells_Human1.72522961
54GABP_19822575_ChIP-Seq_HepG2_Human1.68744262
55MYB_26560356_Chip-Seq_TH1_Human1.68006625
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.67657408
57MAF_26560356_Chip-Seq_TH2_Human1.66327857
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65016514
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63972326
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62927277
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61900662
62SPI1_23127762_ChIP-Seq_K562_Human1.61272841
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59844732
64LXR_22292898_ChIP-Seq_THP-1_Human1.58444129
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58384159
66* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55354992
67RUNX_20019798_ChIP-Seq_JUKART_Human1.54167224
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53674243
69* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53447752
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52264773
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52038958
72GATA3_27048872_Chip-Seq_THYMUS_Human1.51862078
73* ELF1_20517297_ChIP-Seq_JURKAT_Human1.51409335
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50908251
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50769142
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50041343
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.48926470
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48124325
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46748709
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46333713
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45947109
82GATA1_19941826_ChIP-Seq_K562_Human1.45889863
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.44479988
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40551153
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40239667
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39300199
87P68_20966046_ChIP-Seq_HELA_Human1.38765885
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.36994620
89SPI1_23547873_ChIP-Seq_NB4_Human1.35881494
90GATA1_22025678_ChIP-Seq_K562_Human1.35150521
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34973260
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34516459
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30985641
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30761785
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.30166096
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29300571
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28808263
98P300_27268052_Chip-Seq_Bcells_Human1.25485080
99CIITA_25753668_ChIP-Seq_RAJI_Human1.25462328
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24283269
101* E2F1_20622854_ChIP-Seq_HELA_Human1.22801863
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22671612
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21439550
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20800615
105GATA3_26560356_Chip-Seq_TH2_Human1.20731479
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20555598
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20093598
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19668994
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.18946623
110MYC_22102868_ChIP-Seq_BL_Human1.18780722
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18697134
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18405213
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18217648
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15760741
115STAT1_20625510_ChIP-Seq_HELA_Human1.15746845
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15456664
117CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15051423
118TCF7_22412390_ChIP-Seq_EML_Mouse1.14640111
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14532021
120* YY1_22570637_ChIP-Seq_MALME-3M_Human1.14004200
121* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13812140
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13203290
123TTF2_22483619_ChIP-Seq_HELA_Human1.12638578
124VDR_21846776_ChIP-Seq_THP-1_Human1.12528614
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12472810
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11568449
127MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11101803
128* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10824271
129SPI1_20517297_ChIP-Seq_HL60_Human1.09676165
130ELK1_19687146_ChIP-ChIP_HELA_Human1.08373398
131SA1_27219007_Chip-Seq_ERYTHROID_Human1.08150960
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07931602
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07399336
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06707586
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04428099
136ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04368099
137MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03195233
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01517661
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01328430
140KDM5A_27292631_Chip-Seq_BREAST_Human1.01242006
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00851756
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99963321
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99671549
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99010232
145ZNF263_19887448_ChIP-Seq_K562_Human0.97604427
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97085490
147TFEB_21752829_ChIP-Seq_HELA_Human0.95872875
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93716078
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.93684154
150TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93447719
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.92692715
152MAF_26560356_Chip-Seq_TH1_Human0.90578798
153CTCF_26484167_Chip-Seq_Bcells_Mouse0.90369613
154* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89777363
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89670338
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89506215
157* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88665854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.18678441
2MP0003806_abnormal_nucleotide_metabolis4.13475300
3MP0005360_urolithiasis3.99518703
4MP0005085_abnormal_gallbladder_physiolo3.31610480
5MP0009840_abnormal_foam_cell3.13308542
6MP0005365_abnormal_bile_salt3.01865747
7MP0008875_abnormal_xenobiotic_pharmacok2.83976037
8MP0003656_abnormal_erythrocyte_physiolo2.77049729
9MP0003693_abnormal_embryo_hatching2.58091422
10MP0003186_abnormal_redox_activity2.46889134
11MP0003172_abnormal_lysosome_physiology2.42547716
12MP0005083_abnormal_biliary_tract2.40109989
13MP0003191_abnormal_cellular_cholesterol2.35927781
14MP0009785_altered_susceptibility_to2.32212369
15MP0003303_peritoneal_inflammation2.31446262
16MP0001835_abnormal_antigen_presentation2.29787990
17MP0001764_abnormal_homeostasis2.20714225
18MP0003436_decreased_susceptibility_to2.10781052
19MP0003195_calcinosis1.96440097
20MP0005671_abnormal_response_to1.88935624
21MP0009333_abnormal_splenocyte_physiolog1.84560267
22MP0001666_abnormal_nutrient_absorption1.81120958
23MP0005332_abnormal_amino_acid1.80738538
24MP0003763_abnormal_thymus_physiology1.76932677
25MP0005025_abnormal_response_to1.74679339
26MP0000685_abnormal_immune_system1.73452380
27MP0006036_abnormal_mitochondrial_physio1.68947667
28MP0010329_abnormal_lipoprotein_level1.67216323
29MP0004957_abnormal_blastocyst_morpholog1.67061500
30MP0002138_abnormal_hepatobiliary_system1.60124333
31MP0001800_abnormal_humoral_immune1.56448351
32MP0009278_abnormal_bone_marrow1.55764230
33MP0005319_abnormal_enzyme/_coenzyme1.54827008
34MP0008260_abnormal_autophagy1.52607191
35MP0000609_abnormal_liver_physiology1.51692764
36MP0008469_abnormal_protein_level1.51077443
37MP0005000_abnormal_immune_tolerance1.49111151
38MP0003718_maternal_effect1.47507436
39MP0002723_abnormal_immune_serum1.44923428
40MP0009643_abnormal_urine_homeostasis1.44373601
41MP0003252_abnormal_bile_duct1.42810640
42MP0002396_abnormal_hematopoietic_system1.42562756
43MP0005464_abnormal_platelet_physiology1.41435331
44MP0005058_abnormal_lysosome_morphology1.41184759
45MP0004147_increased_porphyrin_level1.41165190
46MP0003075_altered_response_to1.41066419
47MP0002419_abnormal_innate_immunity1.39952302
48MP0002452_abnormal_antigen_presenting1.39143723
49MP0002420_abnormal_adaptive_immunity1.37415879
50MP0000689_abnormal_spleen_morphology1.37182646
51MP0001819_abnormal_immune_cell1.36426598
52MP0002132_abnormal_respiratory_system1.36376206
53MP0002398_abnormal_bone_marrow1.36030813
54MP0005397_hematopoietic_system_phenotyp1.34835556
55MP0001545_abnormal_hematopoietic_system1.34835556
56MP0006082_CNS_inflammation1.34446047
57MP0002148_abnormal_hypersensitivity_rea1.34427286
58MP0005387_immune_system_phenotype1.33999192
59MP0001790_abnormal_immune_system1.33999192
60MP0001853_heart_inflammation1.33750952
61MP0005451_abnormal_body_composition1.32175990
62MP0001845_abnormal_inflammatory_respons1.31652438
63MP0005636_abnormal_mineral_homeostasis1.31623547
64MP0004019_abnormal_vitamin_homeostasis1.31074330
65MP0010155_abnormal_intestine_physiology1.27268392
66MP0000490_abnormal_crypts_of1.26906833
67MP0005075_abnormal_melanosome_morpholog1.26039284
68MP0002722_abnormal_immune_system1.22821732
69MP0000716_abnormal_immune_system1.21768567
70MP0005084_abnormal_gallbladder_morpholo1.20878057
71MP0003111_abnormal_nucleus_morphology1.20749834
72MP0000703_abnormal_thymus_morphology1.19695145
73MP0002429_abnormal_blood_cell1.18121631
74MP0003183_abnormal_peptide_metabolism1.18020637
75MP0001873_stomach_inflammation1.17946343
76MP0003724_increased_susceptibility_to1.17844486
77MP0008058_abnormal_DNA_repair1.15637543
78MP0005584_abnormal_enzyme/coenzyme_acti1.14670806
79MP0003077_abnormal_cell_cycle1.14520736
80MP0000598_abnormal_liver_morphology1.08883144
81MP0004947_skin_inflammation1.07971609
82MP0009765_abnormal_xenobiotic_induced1.06721741
83MP0003866_abnormal_defecation1.05761500
84MP0001986_abnormal_taste_sensitivity1.05326016
85MP0002118_abnormal_lipid_homeostasis1.04265616
86MP0006035_abnormal_mitochondrial_morpho1.03243579
87MP0002405_respiratory_system_inflammati1.02318885
88MP0010094_abnormal_chromosome_stability1.00228589
89MP0008004_abnormal_stomach_pH0.99898053
90MP0009764_decreased_sensitivity_to0.98212066
91MP0009763_increased_sensitivity_to0.97888106
92MP0009697_abnormal_copulation0.97732174
93MP0004782_abnormal_surfactant_physiolog0.97545808
94MP0002019_abnormal_tumor_incidence0.94645692
95MP0005167_abnormal_blood-brain_barrier0.92011643
96MP0000015_abnormal_ear_pigmentation0.90594413
97MP0002166_altered_tumor_susceptibility0.89371599
98MP0000604_amyloidosis0.88855726
99MP0005535_abnormal_body_temperature0.86538602
100MP0000858_altered_metastatic_potential0.85606717
101MP0001533_abnormal_skeleton_physiology0.83707197
102MP0001663_abnormal_digestive_system0.83303361
103MP0003300_gastrointestinal_ulcer0.83219528
104MP0009642_abnormal_blood_homeostasis0.81824013
105MP0009379_abnormal_foot_pigmentation0.81822187
106MP0001756_abnormal_urination0.81299265
107MP0000343_altered_response_to0.77649055
108MP0000465_gastrointestinal_hemorrhage0.75358658
109MP0002277_abnormal_respiratory_mucosa0.74849934
110MP0003786_premature_aging0.74402934
111MP0005646_abnormal_pituitary_gland0.74294069
112MP0004381_abnormal_hair_follicle0.73847685
113MP0001905_abnormal_dopamine_level0.73808760
114MP0001968_abnormal_touch/_nociception0.72765966
115MP0005376_homeostasis/metabolism_phenot0.72609468
116MP0002136_abnormal_kidney_physiology0.72235419
117MP0005410_abnormal_fertilization0.71149486
118MP0001765_abnormal_ion_homeostasis0.69562871
119MP0005166_decreased_susceptibility_to0.69491605
120MP0005220_abnormal_exocrine_pancreas0.68886491
121MP0002006_tumorigenesis0.68432341
122MP0008872_abnormal_physiological_respon0.67125656
123MP0008873_increased_physiological_sensi0.67080967
124MP0005645_abnormal_hypothalamus_physiol0.67008392
125MP0003638_abnormal_response/metabolism_0.66153809
126MP0005390_skeleton_phenotype0.65587103

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.51147128
2Prolonged bleeding time (HP:0003010)4.49566212
3Stomatitis (HP:0010280)4.25976458
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.71189230
5Myositis (HP:0100614)3.59594276
6Mediastinal lymphadenopathy (HP:0100721)3.52927969
7Hepatic necrosis (HP:0002605)3.50572926
8Chronic obstructive pulmonary disease (HP:0006510)3.46867524
9Obstructive lung disease (HP:0006536)3.46867524
10Recurrent fungal infections (HP:0002841)3.32210434
11Hepatocellular necrosis (HP:0001404)3.28576983
12Generalized aminoaciduria (HP:0002909)3.26975725
13Abnormality of cells of the erythroid lineage (HP:0012130)3.25739857
14Gingival bleeding (HP:0000225)3.25082973
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17416727
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17416727
17Abnormal number of erythroid precursors (HP:0012131)3.17403718
18Agammaglobulinemia (HP:0004432)3.15512251
19Abnormality of pyrimidine metabolism (HP:0004353)3.12968121
20Panhypogammaglobulinemia (HP:0003139)3.12110949
21Meningitis (HP:0001287)3.11130520
22Abnormality of B cell number (HP:0010975)3.08156928
23Hypobetalipoproteinemia (HP:0003563)3.03915440
24Prolonged partial thromboplastin time (HP:0003645)3.03307300
25B lymphocytopenia (HP:0010976)2.98865774
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.94339307
27Increased IgE level (HP:0003212)2.91676247
28Nausea (HP:0002018)2.89705078
29Orchitis (HP:0100796)2.89456055
30Encephalitis (HP:0002383)2.88956469
31Intrahepatic cholestasis (HP:0001406)2.80731170
32Xanthomatosis (HP:0000991)2.72727603
33Elevated erythrocyte sedimentation rate (HP:0003565)2.70071460
34Recurrent viral infections (HP:0004429)2.68180149
35Autoimmune hemolytic anemia (HP:0001890)2.67894611
36Deep venous thrombosis (HP:0002625)2.67834668
37Vacuolated lymphocytes (HP:0001922)2.67246303
38Inflammation of the large intestine (HP:0002037)2.66559494
39Gastrointestinal inflammation (HP:0004386)2.65993543
40Mitochondrial inheritance (HP:0001427)2.65718214
41Granulocytopenia (HP:0001913)2.64517864
42Pustule (HP:0200039)2.64307299
43Abnormality of fatty-acid metabolism (HP:0004359)2.62768318
44IgG deficiency (HP:0004315)2.62635739
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.62036215
46Hyperlipoproteinemia (HP:0010980)2.61815012
47Hyperammonemia (HP:0001987)2.60466506
48Reduced antithrombin III activity (HP:0001976)2.60284691
49Increased serum ferritin (HP:0003281)2.59850299
50Optic neuritis (HP:0100653)2.59557158
51Retrobulbar optic neuritis (HP:0100654)2.59557158
52Dicarboxylic aciduria (HP:0003215)2.59177823
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59177823
543-Methylglutaconic aciduria (HP:0003535)2.59129331
55Increased IgM level (HP:0003496)2.58181639
56Petechiae (HP:0000967)2.58142920
57Severe combined immunodeficiency (HP:0004430)2.57555180
58Hyperbilirubinemia (HP:0002904)2.57187846
59Cerebral edema (HP:0002181)2.52488487
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.52279766
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51597224
62Vasculitis (HP:0002633)2.51130446
63Acute hepatic failure (HP:0006554)2.50361676
64Abnormality of T cells (HP:0002843)2.49780091
65Increased cerebral lipofuscin (HP:0011813)2.48569477
66Increased CSF lactate (HP:0002490)2.48442574
67Hyperglycinemia (HP:0002154)2.48411935
68Systemic lupus erythematosus (HP:0002725)2.47831762
69Dysostosis multiplex (HP:0000943)2.46299241
70Lethargy (HP:0001254)2.45630422
71Abnormality of iron homeostasis (HP:0011031)2.44882928
72Increased serum lactate (HP:0002151)2.44193555
73Cellulitis (HP:0100658)2.43541540
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.42879324
75Thrombocytosis (HP:0001894)2.42654488
76Recurrent skin infections (HP:0001581)2.42131759
77Abnormality of the prostate (HP:0008775)2.41776555
78Recurrent cutaneous fungal infections (HP:0011370)2.41149798
79Chronic mucocutaneous candidiasis (HP:0002728)2.41149798
80Recurrent gram-negative bacterial infections (HP:0005420)2.39531781
81Abnormality of macrophages (HP:0004311)2.39483982
82Acute encephalopathy (HP:0006846)2.39255471
83Hyperglycinuria (HP:0003108)2.38398957
84Hepatosplenomegaly (HP:0001433)2.38045826
85Episodic fever (HP:0001954)2.37924352
86Recurrent bacterial skin infections (HP:0005406)2.37905366
87Hypergammaglobulinemia (HP:0010702)2.37757352
88Lactic acidosis (HP:0003128)2.37524012
89Recurrent abscess formation (HP:0002722)2.35873225
90Gastrointestinal infarctions (HP:0005244)2.34654081
91Leukocytosis (HP:0001974)2.33766422
92Abnormality of methionine metabolism (HP:0010901)2.32719681
93Urticaria (HP:0001025)2.32527101
94Menorrhagia (HP:0000132)2.32521982
95Abnormal mitochondria in muscle tissue (HP:0008316)2.31929197
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29308262
97Abnormality of nucleobase metabolism (HP:0010932)2.29204997
98Abnormality of transition element cation homeostasis (HP:0011030)2.28610535
99Hypertensive crisis (HP:0100735)2.24784108
100Acute necrotizing encephalopathy (HP:0006965)2.24695065
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24636224
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24033424
103Joint hemorrhage (HP:0005261)2.22993956
104IgM deficiency (HP:0002850)2.22157111
105Macrocytic anemia (HP:0001972)2.21078958
106Microcytic anemia (HP:0001935)2.19115350
107Abnormality of polysaccharide metabolism (HP:0011012)2.18476004
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18476004
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18476004
110Brushfield spots (HP:0001088)2.17874116
111Pulmonary infiltrates (HP:0002113)2.16119352
112Increased intramyocellular lipid droplets (HP:0012240)2.14992083
113CNS demyelination (HP:0007305)2.14291430
114Increased muscle lipid content (HP:0009058)2.10346594
115Glycosuria (HP:0003076)2.10135589
116Abnormality of urine glucose concentration (HP:0011016)2.10135589
117Skin rash (HP:0000988)2.09756327
118Reticulocytopenia (HP:0001896)2.09289155
119Eczematoid dermatitis (HP:0000976)2.05830611
120Cerebral palsy (HP:0100021)2.05467204
121Joint swelling (HP:0001386)2.05351364
122Abnormality of glycine metabolism (HP:0010895)2.04247680
123Abnormality of serine family amino acid metabolism (HP:0010894)2.04247680
124Abnormality of T cell physiology (HP:0011840)2.04146657
125Type I transferrin isoform profile (HP:0003642)2.03750406
126Chest pain (HP:0100749)2.03430543
127Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02949973
128Oral leukoplakia (HP:0002745)2.02847230
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01465423
130Eosinophilia (HP:0001880)2.01231472
131Hypolipoproteinemia (HP:0010981)2.01223161
132Hypoglycemic coma (HP:0001325)2.01060695
133Spontaneous hematomas (HP:0007420)2.00834819
134Purpura (HP:0000979)2.00811520
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00701720
136Abnormal protein N-linked glycosylation (HP:0012347)2.00701720
137Abnormal protein glycosylation (HP:0012346)2.00701720
138Abnormal glycosylation (HP:0012345)2.00701720
139Gout (HP:0001997)2.00357064
140Poikilocytosis (HP:0004447)1.99506082
141Lipid accumulation in hepatocytes (HP:0006561)1.99105485
142Abnormal platelet volume (HP:0011876)1.99082582
143Abnormality of the anterior horn cell (HP:0006802)1.98460870
144Degeneration of anterior horn cells (HP:0002398)1.98460870
145Combined immunodeficiency (HP:0005387)1.97077434
146Abnormality of serum amino acid levels (HP:0003112)1.96908838
147Pallor (HP:0000980)1.96741608
148Neutropenia (HP:0001875)1.96434365
149Severe visual impairment (HP:0001141)1.96386907
150J-shaped sella turcica (HP:0002680)1.95353316
151Mucopolysacchariduria (HP:0008155)1.94885990
152Urinary glycosaminoglycan excretion (HP:0003541)1.94885990
153Abnormality of liposaccharide metabolism (HP:0010968)1.94468117
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.94468117
155Abnormality of glycolipid metabolism (HP:0010969)1.94468117
156Fat malabsorption (HP:0002630)1.93676213
157Epistaxis (HP:0000421)1.93206846
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93046838
159Abnormality of eosinophils (HP:0001879)1.92280101
160Increased hepatocellular lipid droplets (HP:0006565)1.91565763
161Sepsis (HP:0100806)1.90899262
162Lymphopenia (HP:0001888)1.90811847
163Metabolic acidosis (HP:0001942)1.90690492
164Respiratory failure (HP:0002878)1.90427943
165Autoimmune thrombocytopenia (HP:0001973)1.89069135
166Renal Fanconi syndrome (HP:0001994)1.88876188
167Abnormality of the peritoneum (HP:0002585)1.88840342
168Birth length less than 3rd percentile (HP:0003561)1.88461999
169Microvesicular hepatic steatosis (HP:0001414)1.87520892
170Ketosis (HP:0001946)1.87400763
171Abnormality of purine metabolism (HP:0004352)1.87323434
172Abnormality of the common coagulation pathway (HP:0010990)1.86409318
173Pulmonary fibrosis (HP:0002206)1.84899835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.05233042
2BCKDK3.65345039
3BUB12.91000272
4MAP4K12.71489646
5STK162.58717807
6PIM22.54704996
7EIF2AK12.37526233
8ERN12.28174756
9FES2.23764447
10TESK22.04368151
11BRSK22.03987009
12ARAF2.01394920
13TNK21.99515126
14MAP3K141.92291904
15TBK11.92031656
16WEE11.84469972
17RPS6KA41.81119003
18KDR1.73977884
19IKBKE1.72141576
20TXK1.70785678
21TYK21.67797083
22DYRK31.67644283
23EIF2AK31.63507797
24BRAF1.57535727
25MAP3K121.57376974
26MAP2K31.53386047
27IRAK41.53229911
28ZAP701.52086842
29MAP3K111.51726927
30ACVR1B1.49408540
31BLK1.41230795
32CSK1.39969510
33IRAK31.38216107
34BRSK11.38079170
35BMPR1B1.36808307
36GRK61.36052089
37PIK3CG1.35692506
38TEC1.28201837
39VRK11.26695234
40ABL21.21657890
41MST1R1.19471991
42TAOK31.17132204
43BTK1.16251688
44HCK1.15488535
45VRK21.13440282
46NEK21.12566356
47SCYL21.12215794
48CAMKK21.11827761
49SYK1.09724072
50PLK41.08874312
51IKBKB1.08053981
52MAP3K131.07552350
53MAP2K61.06060622
54PIM11.04963091
55KIT0.98171790
56EPHA20.97702699
57MAPK110.96000175
58MAP4K20.93120977
59NUAK10.90484963
60TAOK10.86604905
61CDK80.86476844
62MATK0.86112823
63MAP3K10.84217682
64BMPR20.82793676
65SIK30.82199218
66TAOK20.81683871
67GRK50.81330229
68FLT30.80719964
69PRKCQ0.80693409
70TSSK60.80080807
71AURKB0.78144727
72FGFR40.77625970
73AURKA0.77539724
74TLK10.77071757
75PRKG20.75194405
76BMX0.74438362
77MAP2K20.74364637
78CDC70.74122767
79PLK10.72907853
80JAK20.67858640
81JAK30.67754083
82LYN0.66935053
83MAP3K30.65897768
84LRRK20.65844657
85SIK20.64766053
86DAPK10.64752542
87CCNB10.62811246
88NEK10.62323561
89RIPK40.61646559
90RPS6KB20.61173892
91MYLK0.60042861
92IRAK20.59655451
93PTK2B0.59252289
94CDK40.58560703
95ADRBK20.58537340
96CHUK0.58341523
97TESK10.58162086
98PRKCI0.58010243
99NME10.57516017
100DAPK20.54191828
101DAPK30.53953352
102RPS6KA60.53912340
103MAPKAPK30.53421290
104RPS6KA50.53009740
105PDK10.52593452
106NLK0.52429169
107STK100.52249000
108JAK10.51697810
109PRPF4B0.51143309
110MAPK120.51138082
111PDPK10.51093818
112NEK90.51089230
113STK40.50607292
114MARK30.49082428
115FGR0.48920078
116DYRK1B0.48405632
117LCK0.48227495
118FYN0.48196613
119ITK0.47570383
120GRK70.47521810
121SRPK10.46469183
122RAF10.45185936
123EPHB10.44921072
124PBK0.44666536
125MST40.44617920
126CDK90.44467483
127CAMKK10.44290310
128CSNK2A10.43502585
129MAPKAPK20.42443160
130TGFBR10.42229342
131CSNK1G30.42100070
132PRKCD0.42067594
133ILK0.41233624
134MAP3K80.39944168
135EIF2AK20.39844449
136GRK10.38700526
137CSF1R0.37527597
138RPS6KC10.37334706
139IRAK10.37057669

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.43364958
2Ribosome_Homo sapiens_hsa030102.83574940
3Graft-versus-host disease_Homo sapiens_hsa053322.77193318
4Autoimmune thyroid disease_Homo sapiens_hsa053202.63523800
5Folate biosynthesis_Homo sapiens_hsa007902.44422592
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.38875913
7Type I diabetes mellitus_Homo sapiens_hsa049402.37191428
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.32255119
9Asthma_Homo sapiens_hsa053102.29125227
10RNA polymerase_Homo sapiens_hsa030202.05480213
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.01857928
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96172210
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95796318
14Sulfur relay system_Homo sapiens_hsa041221.95279701
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93132912
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.91267466
17DNA replication_Homo sapiens_hsa030301.87350262
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85534379
19Osteoclast differentiation_Homo sapiens_hsa043801.84227556
20Pyrimidine metabolism_Homo sapiens_hsa002401.83495058
21Peroxisome_Homo sapiens_hsa041461.74484893
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70660044
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70586021
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70571368
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68342290
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67348630
27B cell receptor signaling pathway_Homo sapiens_hsa046621.62712352
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62240426
29Tuberculosis_Homo sapiens_hsa051521.57278028
30Protein export_Homo sapiens_hsa030601.52512719
31Mismatch repair_Homo sapiens_hsa034301.52465491
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51224774
33Histidine metabolism_Homo sapiens_hsa003401.50590414
34Rheumatoid arthritis_Homo sapiens_hsa053231.50140602
35Vitamin B6 metabolism_Homo sapiens_hsa007501.48837044
36Tryptophan metabolism_Homo sapiens_hsa003801.47944806
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47447528
38Base excision repair_Homo sapiens_hsa034101.43220096
39Oxidative phosphorylation_Homo sapiens_hsa001901.42884688
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.40197624
41Arachidonic acid metabolism_Homo sapiens_hsa005901.38171881
42Fatty acid degradation_Homo sapiens_hsa000711.37973924
43Arginine biosynthesis_Homo sapiens_hsa002201.36846454
44Caffeine metabolism_Homo sapiens_hsa002321.36396655
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36305237
46Homologous recombination_Homo sapiens_hsa034401.31504151
47Platelet activation_Homo sapiens_hsa046111.30669581
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30202252
49T cell receptor signaling pathway_Homo sapiens_hsa046601.29094180
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26979357
51Lysosome_Homo sapiens_hsa041421.26529578
52Pentose phosphate pathway_Homo sapiens_hsa000301.26326471
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26085310
54One carbon pool by folate_Homo sapiens_hsa006701.25733339
55Parkinsons disease_Homo sapiens_hsa050121.25161536
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24090507
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23206175
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22579242
59Sulfur metabolism_Homo sapiens_hsa009201.19363642
60Regulation of autophagy_Homo sapiens_hsa041401.18942940
61Selenocompound metabolism_Homo sapiens_hsa004501.16597508
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15962040
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15722549
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14902906
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14894752
66Carbon metabolism_Homo sapiens_hsa012001.14150786
67Pertussis_Homo sapiens_hsa051331.12156476
68Acute myeloid leukemia_Homo sapiens_hsa052211.12022518
69Complement and coagulation cascades_Homo sapiens_hsa046101.11624948
70Primary immunodeficiency_Homo sapiens_hsa053401.09332450
71beta-Alanine metabolism_Homo sapiens_hsa004101.08614979
72Nucleotide excision repair_Homo sapiens_hsa034201.07543214
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07383223
74Staphylococcus aureus infection_Homo sapiens_hsa051501.07345747
75Chemical carcinogenesis_Homo sapiens_hsa052041.06993615
76Pyruvate metabolism_Homo sapiens_hsa006201.04054336
77Malaria_Homo sapiens_hsa051441.03770622
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03434417
79Propanoate metabolism_Homo sapiens_hsa006401.02394633
80Phagosome_Homo sapiens_hsa041450.94746477
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.94563563
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.94039142
83Butanoate metabolism_Homo sapiens_hsa006500.92485200
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.92304886
85Glutathione metabolism_Homo sapiens_hsa004800.91876005
86Biosynthesis of amino acids_Homo sapiens_hsa012300.91282063
87Collecting duct acid secretion_Homo sapiens_hsa049660.90007613
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.89573281
89Toxoplasmosis_Homo sapiens_hsa051450.88297738
90Viral myocarditis_Homo sapiens_hsa054160.87578353
91Shigellosis_Homo sapiens_hsa051310.87302367
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86849252
93Fructose and mannose metabolism_Homo sapiens_hsa000510.85717055
94Chemokine signaling pathway_Homo sapiens_hsa040620.85221408
95Nitrogen metabolism_Homo sapiens_hsa009100.84406257
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.82159061
97Fatty acid elongation_Homo sapiens_hsa000620.82109576
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.81328368
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81184346
100Phenylalanine metabolism_Homo sapiens_hsa003600.80821368
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79439106
102Purine metabolism_Homo sapiens_hsa002300.79173015
103Other glycan degradation_Homo sapiens_hsa005110.78742330
104Spliceosome_Homo sapiens_hsa030400.78620603
105Legionellosis_Homo sapiens_hsa051340.78119249
106Metabolic pathways_Homo sapiens_hsa011000.76361968
107Retinol metabolism_Homo sapiens_hsa008300.75184191
108RNA transport_Homo sapiens_hsa030130.73980593
109Huntingtons disease_Homo sapiens_hsa050160.73035345
110Fat digestion and absorption_Homo sapiens_hsa049750.72660768
111Influenza A_Homo sapiens_hsa051640.70965823
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70089979
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68289416
114Steroid biosynthesis_Homo sapiens_hsa001000.67721177
115Arginine and proline metabolism_Homo sapiens_hsa003300.67460654
116TNF signaling pathway_Homo sapiens_hsa046680.67032452
117Tyrosine metabolism_Homo sapiens_hsa003500.66080839
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66042853
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65561799
120Linoleic acid metabolism_Homo sapiens_hsa005910.64594082
121Antigen processing and presentation_Homo sapiens_hsa046120.64057798
122Alzheimers disease_Homo sapiens_hsa050100.63620887
123Endocytosis_Homo sapiens_hsa041440.63520698
124Systemic lupus erythematosus_Homo sapiens_hsa053220.63391183
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62344190
126ABC transporters_Homo sapiens_hsa020100.61306519
127Glycerolipid metabolism_Homo sapiens_hsa005610.58610785
128Galactose metabolism_Homo sapiens_hsa000520.58340309
129Vitamin digestion and absorption_Homo sapiens_hsa049770.58266485
130Fatty acid metabolism_Homo sapiens_hsa012120.57404261
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55958745
132Starch and sucrose metabolism_Homo sapiens_hsa005000.55753602
133Apoptosis_Homo sapiens_hsa042100.54923579
134African trypanosomiasis_Homo sapiens_hsa051430.54503562
135Salmonella infection_Homo sapiens_hsa051320.54280984
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53373327
137Epstein-Barr virus infection_Homo sapiens_hsa051690.49684460
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.49377216
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49225946
140Measles_Homo sapiens_hsa051620.49213033
141Renin-angiotensin system_Homo sapiens_hsa046140.48950471
142Leishmaniasis_Homo sapiens_hsa051400.47116658
143PPAR signaling pathway_Homo sapiens_hsa033200.46551848
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45714354
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45655015
146Herpes simplex infection_Homo sapiens_hsa051680.44976754
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.44877222
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44633759
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44397839
150Hepatitis C_Homo sapiens_hsa051600.44184001
151Hematopoietic cell lineage_Homo sapiens_hsa046400.43266308
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43226920
153Cell cycle_Homo sapiens_hsa041100.41857905
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40578296
155Allograft rejection_Homo sapiens_hsa053300.40483066
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39810491
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.34372424

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