ZFAND3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)4.30643068
2diaphragm development (GO:0060539)4.16189195
33-UTR-mediated mRNA stabilization (GO:0070935)4.08318118
4skeletal muscle organ development (GO:0060538)4.03011774
5positive regulation of fatty acid beta-oxidation (GO:0032000)3.92397679
6low-density lipoprotein particle clearance (GO:0034383)3.88350385
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82219846
8L-phenylalanine catabolic process (GO:0006559)3.82219846
9L-phenylalanine metabolic process (GO:0006558)3.79351479
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79351479
11regulation of fatty acid beta-oxidation (GO:0031998)3.71011334
12hypotonic response (GO:0006971)3.70648840
13sulfur amino acid catabolic process (GO:0000098)3.68589635
14negative regulation of granulocyte differentiation (GO:0030853)3.63379378
15negative regulation of fibrinolysis (GO:0051918)3.59999380
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58999063
17activation of MAPKKK activity (GO:0000185)3.54663075
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.45330934
19lysine catabolic process (GO:0006554)3.44709918
20lysine metabolic process (GO:0006553)3.44709918
21fatty acid transmembrane transport (GO:1902001)3.42110280
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.40143459
23plasma lipoprotein particle clearance (GO:0034381)3.38066179
24negative regulation of vascular permeability (GO:0043116)3.36736932
25complement activation, alternative pathway (GO:0006957)3.34951842
26regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.31498441
27regulation of cholesterol homeostasis (GO:2000188)3.27041608
28positive regulation of fatty acid oxidation (GO:0046321)3.26766266
29carnitine shuttle (GO:0006853)3.26563606
30glyoxylate metabolic process (GO:0046487)3.25583692
31positive regulation of lipid catabolic process (GO:0050996)3.25008591
32peptidyl-glutamic acid carboxylation (GO:0017187)3.23854597
33protein carboxylation (GO:0018214)3.23854597
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19020621
35cysteine metabolic process (GO:0006534)3.15871146
36positive regulation of cell size (GO:0045793)3.11715733
37regulation of triglyceride catabolic process (GO:0010896)3.11095313
38regulation of fibrinolysis (GO:0051917)3.10012098
39regulation of fatty acid oxidation (GO:0046320)3.09466366
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08440430
41protein heterotrimerization (GO:0070208)3.07064417
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06083483
43negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.04564391
44regulation of protein activation cascade (GO:2000257)3.01961565
45plasma membrane repair (GO:0001778)3.01871882
46urea metabolic process (GO:0019627)3.00646870
47urea cycle (GO:0000050)3.00646870
48positive regulation of receptor recycling (GO:0001921)3.00151027
49acetyl-CoA metabolic process (GO:0006084)3.00040044
50stress fiber assembly (GO:0043149)2.99559171
51aromatic amino acid family catabolic process (GO:0009074)2.98645925
52fatty acid beta-oxidation (GO:0006635)2.97808565
532-oxoglutarate metabolic process (GO:0006103)2.96285117
54regulation of early endosome to late endosome transport (GO:2000641)2.95292338
55adherens junction assembly (GO:0034333)2.92544357
56regulation of complement activation (GO:0030449)2.92111082
57negative regulation of erythrocyte differentiation (GO:0045647)2.90759186
58negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.87973131
59aspartate family amino acid catabolic process (GO:0009068)2.87146781
60regulation of cholesterol storage (GO:0010885)2.81809148
61amino-acid betaine metabolic process (GO:0006577)2.81568049
62RNA stabilization (GO:0043489)2.80758804
63mRNA stabilization (GO:0048255)2.80758804
64amino-acid betaine transport (GO:0015838)2.80211516
65carnitine transport (GO:0015879)2.80211516
66regulation of sequestering of triglyceride (GO:0010889)2.79707114
67carnitine transmembrane transport (GO:1902603)2.79412184
68cellular protein complex localization (GO:0034629)2.78804857
69syncytium formation by plasma membrane fusion (GO:0000768)2.78276499
70camera-type eye morphogenesis (GO:0048593)2.77818407
71kynurenine metabolic process (GO:0070189)2.76922040
72bile acid biosynthetic process (GO:0006699)2.75842819
73nitrogen cycle metabolic process (GO:0071941)2.75202754
74fatty acid oxidation (GO:0019395)2.75151449
75myoblast fusion (GO:0007520)2.74828432
76negative regulation of cell size (GO:0045792)2.74652952
77phospholipid homeostasis (GO:0055091)2.74539800
78skin morphogenesis (GO:0043589)2.74175201
79high-density lipoprotein particle remodeling (GO:0034375)2.73121380
80positive regulation of triglyceride metabolic process (GO:0090208)2.72747405
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.72660457
82apoptotic cell clearance (GO:0043277)2.72503292
83negative regulation of cholesterol transport (GO:0032375)2.71788770
84negative regulation of sterol transport (GO:0032372)2.71788770
85epoxygenase P450 pathway (GO:0019373)2.71561479
86lipid oxidation (GO:0034440)2.69669519
87fatty acid catabolic process (GO:0009062)2.67321072
88response to lipoprotein particle (GO:0055094)2.67221190
89regulation of NFAT protein import into nucleus (GO:0051532)2.67055824
904-hydroxyproline metabolic process (GO:0019471)2.66501061
91regulation of extracellular matrix disassembly (GO:0010715)2.66072367
92modulation by symbiont of host immune response (GO:0052553)2.63689233
93positive regulation by symbiont of host defense response (GO:0052509)2.63689233
94modulation by symbiont of host defense response (GO:0052031)2.63689233
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63689233
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63689233
97positive regulation by organism of defense response of other organism involved in symbiotic interact2.63689233
98cell-substrate adherens junction assembly (GO:0007045)2.63673243
99focal adhesion assembly (GO:0048041)2.63673243
100regulation of monocyte differentiation (GO:0045655)2.63590330
101pyrimidine-containing compound salvage (GO:0008655)2.63337980
102pyrimidine nucleoside salvage (GO:0043097)2.63337980
103cellular response to nerve growth factor stimulus (GO:1990090)2.63033392
104response to nerve growth factor (GO:1990089)2.63033392
105insulin-like growth factor receptor signaling pathway (GO:0048009)2.62803253
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.61704771
107homocysteine metabolic process (GO:0050667)2.61388410
108regulation of cholesterol biosynthetic process (GO:0045540)2.61123553
109modulation by symbiont of host cellular process (GO:0044068)2.60817376
110positive regulation of fatty acid metabolic process (GO:0045923)2.60590531
111creatine metabolic process (GO:0006600)2.59958078
112acylglycerol homeostasis (GO:0055090)2.59585138
113triglyceride homeostasis (GO:0070328)2.59585138
114ethanol oxidation (GO:0006069)2.58619252
115regulation of p38MAPK cascade (GO:1900744)2.56082004
116cellular modified amino acid catabolic process (GO:0042219)2.55668160
117cellular ketone body metabolic process (GO:0046950)2.54919982
118negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.54314344
119reverse cholesterol transport (GO:0043691)2.53765734
120response to mercury ion (GO:0046689)2.52797992
121positive regulation of glycogen biosynthetic process (GO:0045725)2.52781985
122arginine catabolic process (GO:0006527)2.52257722
123positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51900095
124short-chain fatty acid metabolic process (GO:0046459)2.50833545
125monocarboxylic acid catabolic process (GO:0072329)2.49743840
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49362342
127negative regulation of calcium ion transport into cytosol (GO:0010523)2.48368224
128valine metabolic process (GO:0006573)2.46770668
129regulation of plasminogen activation (GO:0010755)2.46657706
130fibrinolysis (GO:0042730)2.45888133
131regulation of lipid catabolic process (GO:0050994)2.45499004
132protein localization to endosome (GO:0036010)2.44856854
133serine family amino acid catabolic process (GO:0009071)2.42155148
134carnitine metabolic process (GO:0009437)2.42028515
135acylglycerol catabolic process (GO:0046464)2.41133751
136neutral lipid catabolic process (GO:0046461)2.41133751
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.40264533
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39810240
139bile acid metabolic process (GO:0008206)2.39515441
140cell-substrate junction assembly (GO:0007044)2.38738007
141response to laminar fluid shear stress (GO:0034616)2.38652914
142protein-lipid complex assembly (GO:0065005)2.38101311
143positive regulation of glycogen metabolic process (GO:0070875)2.37564878
144tyrosine metabolic process (GO:0006570)2.35784461
145negative regulation of lipid transport (GO:0032369)2.35459156
146phospholipid efflux (GO:0033700)2.34694825
147nerve growth factor signaling pathway (GO:0038180)2.34532729
148positive regulation of lipid storage (GO:0010884)2.34321898
149basement membrane organization (GO:0071711)2.33732767
150platelet-derived growth factor receptor signaling pathway (GO:0048008)2.33307028
151plasma lipoprotein particle remodeling (GO:0034369)2.33209807
152protein-lipid complex remodeling (GO:0034368)2.33209807
153macromolecular complex remodeling (GO:0034367)2.33209807
154regulation of triglyceride metabolic process (GO:0090207)2.32734150
155growth hormone receptor signaling pathway (GO:0060396)2.32633595
156negative regulation of potassium ion transmembrane transport (GO:1901380)2.32381572
157midgut development (GO:0007494)2.32194456
158negative regulation of catenin import into nucleus (GO:0035414)2.30844741
159positive regulation of extracellular matrix organization (GO:1903055)2.30473635
160modulation by virus of host process (GO:0019054)2.30246036
161endocytic recycling (GO:0032456)2.30147522
162positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.29771211
163negative regulation of fatty acid transport (GO:2000192)2.27167963
164cortical actin cytoskeleton organization (GO:0030866)2.27122652
165semaphorin-plexin signaling pathway (GO:0071526)2.26300934
166positive regulation of adherens junction organization (GO:1903393)2.24852677
167epithelial cell-cell adhesion (GO:0090136)2.24288787
168modulation by virus of host morphology or physiology (GO:0019048)2.24146097
169positive regulation of protein export from nucleus (GO:0046827)2.24128259
170negative regulation of neurotransmitter transport (GO:0051589)2.23262446
171positive regulation of myotube differentiation (GO:0010831)2.21996314
172cell-cell junction maintenance (GO:0045217)2.21515275
173retrograde transport, endosome to Golgi (GO:0042147)2.21365059
174barbed-end actin filament capping (GO:0051016)2.20863362
175protein targeting to plasma membrane (GO:0072661)2.18550714
176regulation of protein deacetylation (GO:0090311)2.18407589
177negative regulation of potassium ion transport (GO:0043267)2.14603885
178regulation of peptidyl-threonine phosphorylation (GO:0010799)2.14207240
179activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12639486
180response to host (GO:0075136)2.10215984
181response to host defenses (GO:0052200)2.10215984
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.10215984
183negative regulation of glial cell proliferation (GO:0060253)2.09318435
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.09105612
185positive regulation of Rap GTPase activity (GO:0032854)2.08695147
186maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.07922753
187negative regulation of protein kinase B signaling (GO:0051898)2.07876425
188regulation of glucose import in response to insulin stimulus (GO:2001273)2.07869482
189negative regulation of Ras protein signal transduction (GO:0046580)2.07394900
190antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.06965551
191protein retention in ER lumen (GO:0006621)2.06747162
192venous blood vessel morphogenesis (GO:0048845)2.06575135
193negative regulation of homotypic cell-cell adhesion (GO:0034111)2.06323441
194regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.05482631
195response to acidic pH (GO:0010447)2.02453271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02342366
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.41670115
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.76830320
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40975916
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.28070277
6EZH2_22144423_ChIP-Seq_EOC_Human2.93615756
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76123286
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.41213104
9CLOCK_20551151_ChIP-Seq_293T_Human2.37804571
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.32546530
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.22511731
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17041551
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14969572
14ZNF263_19887448_ChIP-Seq_K562_Human2.13476539
15VDR_21846776_ChIP-Seq_THP-1_Human2.02964506
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93264240
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84946735
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83059573
19MYC_22102868_ChIP-Seq_BL_Human1.81720530
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.76332824
21LXR_22292898_ChIP-Seq_THP-1_Human1.73778177
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72066607
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63122484
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61529665
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.51581194
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.51581194
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.46570421
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45046577
29* KDM2B_26808549_Chip-Seq_K562_Human1.45041468
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44633645
31KDM2B_26808549_Chip-Seq_DND41_Human1.42901308
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42607153
33RACK7_27058665_Chip-Seq_MCF-7_Human1.40780194
34VDR_24763502_ChIP-Seq_THP-1_Human1.40772842
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39907010
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39781419
37* GATA1_19941827_ChIP-Seq_MEL_Mouse1.38767911
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38731320
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36704459
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33315387
41* EP300_21415370_ChIP-Seq_HL-1_Mouse1.31024843
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30286017
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29659438
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29482211
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29002032
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26856752
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26713856
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.26693861
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25850931
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25537706
51* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24272667
52* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22277988
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.22163589
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22020795
55DROSHA_22980978_ChIP-Seq_HELA_Human1.21218330
56* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21161951
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20233348
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19049774
59TP53_22127205_ChIP-Seq_IMR90_Human1.18638437
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.17738279
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17042336
62SCL_19346495_ChIP-Seq_HPC-7_Human1.15647002
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15645781
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13997641
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13702019
66* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13059517
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12606138
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12245560
69* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12032039
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11547255
71* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11079610
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10939135
73* MAF_26560356_Chip-Seq_TH1_Human1.10222968
74CREB1_26743006_Chip-Seq_LNCaP_Human1.08672345
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.08573194
76RUNX_20019798_ChIP-Seq_JUKART_Human1.08103322
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07700437
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07171593
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.06542789
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05941178
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.05851676
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05342094
83TCF7_22412390_ChIP-Seq_EML_Mouse1.04647873
84SPI1_23127762_ChIP-Seq_K562_Human1.04547195
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.03926140
86* ATF3_27146783_Chip-Seq_COLON_Human1.02328709
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.01597669
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.00521703
89RUNX1_22412390_ChIP-Seq_EML_Mouse0.99296664
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97844740
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96678745
92* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96132698
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95824725
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95610019
95UTX_26944678_Chip-Seq_JUKART_Human0.95048188
96NCOR1_26117541_ChIP-Seq_K562_Human0.94367187
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93281834
98* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93259220
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93239958
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93108187
101CTCF_27219007_Chip-Seq_Bcells_Human0.92744563
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92573771
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91616462
104* TP63_22573176_ChIP-Seq_HFKS_Human0.90388803
105SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90036843
106SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89917851
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89620661
108CJUN_26792858_Chip-Seq_BT549_Human0.89431898
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88714657
110UBF1/2_26484160_Chip-Seq_HMECs_Human0.88603934
111GATA2_19941826_ChIP-Seq_K562_Human0.88500355
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88333882
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86988144
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86289347
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85232217
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84695039
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84221645
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83917502
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83459278
120SMC4_20622854_ChIP-Seq_HELA_Human0.83433799
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83248022
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.82983184
123GATA1_19941826_ChIP-Seq_K562_Human0.82686934
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81475578
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81469087
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.81293022
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79161716
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79029630
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78922569
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.78462463
131* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77790588
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77619854
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77295916
134* ISL1_27105846_Chip-Seq_CPCs_Mouse0.77068169
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77034876
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77003933
137P68_20966046_ChIP-Seq_HELA_Human0.75783579
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.75505408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.98983013
2MP0003705_abnormal_hypodermis_morpholog3.82991264
3MP0000566_synostosis3.74008283
4MP0005360_urolithiasis3.66078359
5MP0008438_abnormal_cutaneous_collagen3.14142349
6MP0005365_abnormal_bile_salt2.81206997
7MP0005085_abnormal_gallbladder_physiolo2.79912860
8MP0002837_dystrophic_cardiac_calcinosis2.62982845
9MP0004130_abnormal_muscle_cell2.48608645
10MP0005670_abnormal_white_adipose2.41510937
11MP0009840_abnormal_foam_cell2.36680121
12MP0005409_darkened_coat_color2.29869227
13MP0003252_abnormal_bile_duct2.18896427
14MP0010329_abnormal_lipoprotein_level2.17445736
15MP0005666_abnormal_adipose_tissue2.08660850
16MP0005257_abnormal_intraocular_pressure2.06954737
17MP0008875_abnormal_xenobiotic_pharmacok2.05755963
18MP0000751_myopathy2.03552625
19MP0005083_abnormal_biliary_tract2.02137480
20MP0004185_abnormal_adipocyte_glucose1.97729613
21MP0005275_abnormal_skin_tensile1.96745927
22MP0005623_abnormal_meninges_morphology1.96724725
23MP0003191_abnormal_cellular_cholesterol1.89611253
24MP0004272_abnormal_basement_membrane1.81285286
25MP0003436_decreased_susceptibility_to1.70652909
26MP0004087_abnormal_muscle_fiber1.68343504
27MP0006082_CNS_inflammation1.68082761
28MP0004084_abnormal_cardiac_muscle1.63720209
29MP0003566_abnormal_cell_adhesion1.58524889
30MP0005375_adipose_tissue_phenotype1.55468712
31MP0004036_abnormal_muscle_relaxation1.52945486
32MP0002118_abnormal_lipid_homeostasis1.49525910
33MP0003279_aneurysm1.46705688
34MP0010368_abnormal_lymphatic_system1.45682796
35MP0005332_abnormal_amino_acid1.43992784
36MP0003828_pulmonary_edema1.41822124
37MP0003646_muscle_fatigue1.40657759
38MP0008260_abnormal_autophagy1.40384889
39MP0000858_altered_metastatic_potential1.39672752
40MP0000750_abnormal_muscle_regeneration1.38224450
41MP0009053_abnormal_anal_canal1.35491051
42MP0003806_abnormal_nucleotide_metabolis1.33532830
43MP0005330_cardiomyopathy1.33427539
44MP0004858_abnormal_nervous_system1.33350776
45MP0000749_muscle_degeneration1.31963469
46MP0001666_abnormal_nutrient_absorption1.30711444
47MP0010234_abnormal_vibrissa_follicle1.29625854
48MP0003300_gastrointestinal_ulcer1.29349303
49MP0002998_abnormal_bone_remodeling1.28268470
50MP0000733_abnormal_muscle_development1.28082277
51MP0000609_abnormal_liver_physiology1.28043009
52MP0003075_altered_response_to1.25030735
53MP0010630_abnormal_cardiac_muscle1.24901906
54MP0003123_paternal_imprinting1.24748388
55MP0001533_abnormal_skeleton_physiology1.24058784
56MP0002269_muscular_atrophy1.21915112
57MP0009384_cardiac_valve_regurgitation1.20346729
58MP0002971_abnormal_brown_adipose1.20011408
59MP0000747_muscle_weakness1.19028603
60MP0003283_abnormal_digestive_organ1.18784492
61MP0008961_abnormal_basal_metabolism1.18437493
62MP0005167_abnormal_blood-brain_barrier1.18142157
63MP0003172_abnormal_lysosome_physiology1.16695834
64MP0005410_abnormal_fertilization1.16611707
65MP0004043_abnormal_pH_regulation1.14115687
66MP0005620_abnormal_muscle_contractility1.14034923
67MP0000759_abnormal_skeletal_muscle1.13757389
68MP0003195_calcinosis1.12963748
69MP0001348_abnormal_lacrimal_gland1.12526428
70MP0005451_abnormal_body_composition1.12250457
71MP0004145_abnormal_muscle_electrophysio1.11983018
72MP0005464_abnormal_platelet_physiology1.11711226
73MP0000467_abnormal_esophagus_morphology1.09663828
74MP0005319_abnormal_enzyme/_coenzyme1.08993600
75MP0003091_abnormal_cell_migration1.06146954
76MP0001958_emphysema1.05190917
77MP0006138_congestive_heart_failure1.01349197
78MP0002138_abnormal_hepatobiliary_system1.01136759
79MP0005076_abnormal_cell_differentiation1.00945127
80MP0008775_abnormal_heart_ventricle1.00027040
81MP0002106_abnormal_muscle_physiology0.99408641
82MP0002089_abnormal_postnatal_growth/wei0.98536762
83MP0005385_cardiovascular_system_phenoty0.98436745
84MP0001544_abnormal_cardiovascular_syste0.98436745
85MP0002972_abnormal_cardiac_muscle0.98177718
86MP0003303_peritoneal_inflammation0.97623535
87MP0003942_abnormal_urinary_system0.96070016
88MP0005390_skeleton_phenotype0.95410514
89MP0002282_abnormal_trachea_morphology0.95295324
90MP0004233_abnormal_muscle_weight0.94592769
91MP0002877_abnormal_melanocyte_morpholog0.94444664
92MP0002295_abnormal_pulmonary_circulatio0.93741166
93MP0003724_increased_susceptibility_to0.92490863
94MP0003879_abnormal_hair_cell0.91719169
95MP0000003_abnormal_adipose_tissue0.91207237
96MP0005503_abnormal_tendon_morphology0.89390456
97MP0000767_abnormal_smooth_muscle0.89088425
98MP0005023_abnormal_wound_healing0.88286389
99MP0004883_abnormal_blood_vessel0.87916030
100MP0002234_abnormal_pharynx_morphology0.87289730
101MP0002113_abnormal_skeleton_development0.86917126
102MP0005584_abnormal_enzyme/coenzyme_acti0.86676421
103MP0004510_myositis0.86647654
104MP0004947_skin_inflammation0.86600688
105MP0005248_abnormal_Harderian_gland0.86468136
106MP0009643_abnormal_urine_homeostasis0.85724807
107MP0009278_abnormal_bone_marrow0.85513396
108MP0004019_abnormal_vitamin_homeostasis0.85178661
109MP0005369_muscle_phenotype0.84198790
110MP0002249_abnormal_larynx_morphology0.83816358
111MP0003329_amyloid_beta_deposits0.83727442
112MP0000604_amyloidosis0.83053047
113MP0002896_abnormal_bone_mineralization0.82955741
114MP0002108_abnormal_muscle_morphology0.82690845
115MP0000537_abnormal_urethra_morphology0.81526898
116MP0005334_abnormal_fat_pad0.81482518
117MP0005058_abnormal_lysosome_morphology0.81360685
118MP0003045_fibrosis0.81106009
119MP0002168_other_aberrant_phenotype0.80520714
120MP0005164_abnormal_response_to0.77967484
121MP0002796_impaired_skin_barrier0.77698134
122MP0001915_intracranial_hemorrhage0.77522245
123MP0003448_altered_tumor_morphology0.76930840
124MP0002128_abnormal_blood_circulation0.76818376
125MP0001879_abnormal_lymphatic_vessel0.76569295
126MP0009115_abnormal_fat_cell0.76485901
127MP0003453_abnormal_keratinocyte_physiol0.76173908
128MP0001849_ear_inflammation0.75398387
129MP0005508_abnormal_skeleton_morphology0.75315144
130MP0000343_altered_response_to0.74949244
131MP0002419_abnormal_innate_immunity0.74459586
132MP0000534_abnormal_ureter_morphology0.74266767
133MP0000685_abnormal_immune_system0.74259556
134MP0008874_decreased_physiological_sensi0.72513842
135MP0003634_abnormal_glial_cell0.72133464
136MP0000678_abnormal_parathyroid_gland0.71506728
137MP0001614_abnormal_blood_vessel0.71137338
138MP0003183_abnormal_peptide_metabolism0.69777292
139MP0005197_abnormal_uvea_morphology0.69095844
140MP0003115_abnormal_respiratory_system0.68839109
141MP0005166_decreased_susceptibility_to0.67720450
142MP0002127_abnormal_cardiovascular_syste0.66749308
143MP0002116_abnormal_craniofacial_bone0.66532362
144MP0003878_abnormal_ear_physiology0.66001668
145MP0005377_hearing/vestibular/ear_phenot0.66001668
146MP0000249_abnormal_blood_vessel0.65640723

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.62867076
2Abnormality of the fingertips (HP:0001211)3.88938804
3Xanthomatosis (HP:0000991)3.63064918
4Sparse lateral eyebrow (HP:0005338)3.53126558
5Hyporeflexia of lower limbs (HP:0002600)3.52994904
6Obstructive sleep apnea (HP:0002870)3.43841683
7Protrusio acetabuli (HP:0003179)3.41897228
8Complement deficiency (HP:0004431)3.38776497
9Muscle fiber splitting (HP:0003555)3.20566045
10Exercise-induced myalgia (HP:0003738)3.15853366
11Increased connective tissue (HP:0009025)3.10899039
12Lip pit (HP:0100267)3.06956879
13Type 1 muscle fiber predominance (HP:0003803)3.05662132
14Broad metatarsal (HP:0001783)3.03251191
15Difficulty running (HP:0009046)3.01055932
16Premature rupture of membranes (HP:0001788)2.99961115
17Myoglobinuria (HP:0002913)2.97269316
18Asymmetric septal hypertrophy (HP:0001670)2.95006778
19Cerebral aneurysm (HP:0004944)2.93246396
20Hyperlipoproteinemia (HP:0010980)2.92505551
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.91213977
22Long palpebral fissure (HP:0000637)2.87684026
23Autoimmune thrombocytopenia (HP:0001973)2.86093609
24Right ventricular cardiomyopathy (HP:0011663)2.84896567
25Sudden death (HP:0001699)2.81317389
26Hypoalphalipoproteinemia (HP:0003233)2.77897239
27Exercise-induced muscle cramps (HP:0003710)2.77721464
28Neonatal short-limb short stature (HP:0008921)2.76706152
29Anal stenosis (HP:0002025)2.70226098
30Ketosis (HP:0001946)2.70025964
31Intrahepatic cholestasis (HP:0001406)2.68276348
32Dysostosis multiplex (HP:0000943)2.67854271
33Urinary glycosaminoglycan excretion (HP:0003541)2.64280812
34Mucopolysacchariduria (HP:0008155)2.64280812
35Shallow orbits (HP:0000586)2.62067612
36Abnormality of complement system (HP:0005339)2.61133562
37Difficulty climbing stairs (HP:0003551)2.60367847
38Peritonitis (HP:0002586)2.58501059
39Asymmetry of the thorax (HP:0001555)2.54345017
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53573190
41Disproportionate tall stature (HP:0001519)2.49344670
42Hyperacusis (HP:0010780)2.46719204
43Increased variability in muscle fiber diameter (HP:0003557)2.46193862
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45187111
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45187111
46Abnormality of polysaccharide metabolism (HP:0011012)2.45187111
47Abnormality of the Achilles tendon (HP:0005109)2.44433289
48Lymphangioma (HP:0100764)2.43926856
49Hyperammonemia (HP:0001987)2.40769715
50Hypolipoproteinemia (HP:0010981)2.39674203
51Myocardial infarction (HP:0001658)2.38159296
52Epidermoid cyst (HP:0200040)2.35328280
53Mitral valve prolapse (HP:0001634)2.32202544
54Blue sclerae (HP:0000592)2.31006401
55Vascular tortuosity (HP:0004948)2.30118657
56Ketoacidosis (HP:0001993)2.29425276
57Hemorrhage of the eye (HP:0011885)2.29194259
58Distal upper limb amyotrophy (HP:0007149)2.28041418
59Upper limb amyotrophy (HP:0009129)2.28041418
60Arterial tortuosity (HP:0005116)2.27987490
61Skin nodule (HP:0200036)2.27894572
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27079914
63Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26955371
64Hypobetalipoproteinemia (HP:0003563)2.26804728
65Broad face (HP:0000283)2.26499703
66Ventricular tachycardia (HP:0004756)2.22949783
67Polycythemia (HP:0001901)2.22826015
68Natal tooth (HP:0000695)2.21485532
69Achilles tendon contracture (HP:0001771)2.19401824
70Abnormal cartilage morphology (HP:0002763)2.18342523
71Genu recurvatum (HP:0002816)2.17477977
72Aneurysm (HP:0002617)2.17179151
73Turricephaly (HP:0000262)2.16592600
74Intestinal fistula (HP:0100819)2.16517631
75Back pain (HP:0003418)2.15611240
76Esophageal varix (HP:0002040)2.13793541
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.13763608
78Spinal rigidity (HP:0003306)2.12420365
79Round ear (HP:0100830)2.12091131
80Abnormality of skeletal muscle fiber size (HP:0012084)2.09415810
81Ureteral stenosis (HP:0000071)2.07905382
82Hyperglycinuria (HP:0003108)2.07878329
83Hypoglycemic coma (HP:0001325)2.06239148
84Vertebral compression fractures (HP:0002953)2.05128430
85Hypercholesterolemia (HP:0003124)2.02873435
86Depressed nasal tip (HP:0000437)2.02724877
87Vertebral hypoplasia (HP:0008417)2.02576057
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02576057
89Visceral angiomatosis (HP:0100761)2.02412615
90Short 5th finger (HP:0009237)2.02099584
91Abnormality of glycine metabolism (HP:0010895)2.02042097
92Abnormality of serine family amino acid metabolism (HP:0010894)2.02042097
93Aortic dissection (HP:0002647)2.01408396
94EMG: myopathic abnormalities (HP:0003458)2.00664576
95Flat acetabular roof (HP:0003180)2.00292655
96Abnormality of the common coagulation pathway (HP:0010990)1.99752618
97Mitral regurgitation (HP:0001653)1.99477277
98Abnormality of the distal phalanges of the toes (HP:0010182)1.98223428
99Long toe (HP:0010511)1.97531836
100Rhabdomyolysis (HP:0003201)1.96354373
101Emphysema (HP:0002097)1.95279812
102Ankle contracture (HP:0006466)1.94887166
103Aortic aneurysm (HP:0004942)1.94285090
104Systemic lupus erythematosus (HP:0002725)1.93413456
105Hand muscle atrophy (HP:0009130)1.93056753
106Mask-like facies (HP:0000298)1.92195947
107Mildly elevated creatine phosphokinase (HP:0008180)1.91794797
108Bundle branch block (HP:0011710)1.90749856
109Coronal craniosynostosis (HP:0004440)1.89894249
110Cervical subluxation (HP:0003308)1.89174961
111Hyperglycinemia (HP:0002154)1.88720173
112Muscle fiber inclusion bodies (HP:0100299)1.86212288
113Buphthalmos (HP:0000557)1.86100386
114Muscle hypertrophy of the lower extremities (HP:0008968)1.85937811
115Atrophic scars (HP:0001075)1.84951523
116Ureteral obstruction (HP:0006000)1.84792337
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84619088
118Calf muscle hypertrophy (HP:0008981)1.84339754
119Cardiovascular calcification (HP:0011915)1.83753823
120Neurofibrillary tangles (HP:0002185)1.83632249
121Abnormality of the calf musculature (HP:0001430)1.81718530
122Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80260439
123Fragile skin (HP:0001030)1.80259100
124Abnormality of fatty-acid metabolism (HP:0004359)1.80160203
125Nephritis (HP:0000123)1.79894641
126Distal lower limb muscle weakness (HP:0009053)1.79716787
127Atrioventricular block (HP:0001678)1.79554096
128Hemangiomatosis (HP:0007461)1.79088483
129Advanced eruption of teeth (HP:0006288)1.78911921
130Renal cell carcinoma (HP:0005584)1.77865079
131Stroke (HP:0001297)1.77663069
132Ulnar deviation of the wrist (HP:0003049)1.77548669
133Broad thumb (HP:0011304)1.77449588
134Muscle stiffness (HP:0003552)1.77168501
135Scapular winging (HP:0003691)1.76897618
136Thin ribs (HP:0000883)1.76432755
137Hyperparathyroidism (HP:0000843)1.76234750
138Slender build (HP:0001533)1.75747321
139Thin bony cortex (HP:0002753)1.75193303
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74678394
141Lipoatrophy (HP:0100578)1.73938461
142Prolonged partial thromboplastin time (HP:0003645)1.73619507
143Dilatation of the ascending aorta (HP:0005111)1.72678187
144Precocious puberty (HP:0000826)1.72296033
145Cholelithiasis (HP:0001081)1.72213927
146Gout (HP:0001997)1.71401219
147Cerebral inclusion bodies (HP:0100314)1.71081876
148Hydroxyprolinuria (HP:0003080)1.70879439
149Abnormality of proline metabolism (HP:0010907)1.70879439
150Neonatal death (HP:0003811)1.70648561
151Preauricular pit (HP:0004467)1.70411659
152Periauricular skin pits (HP:0100277)1.70411659
153Acanthosis nigricans (HP:0000956)1.69969655
154Distal lower limb amyotrophy (HP:0008944)1.69079690
155Vascular calcification (HP:0004934)1.68910288
156Abnormal gallbladder physiology (HP:0012438)1.68716518
157Cholecystitis (HP:0001082)1.68716518
158Bladder diverticulum (HP:0000015)1.68184467
159Wide anterior fontanel (HP:0000260)1.68129334
160Coxa vara (HP:0002812)1.67921127
161Hyperextensible skin (HP:0000974)1.67444785
162Fatigue (HP:0012378)1.67040762
163Congenital hip dislocation (HP:0001374)1.65793069
164Narrow palate (HP:0000189)1.64994599
165Popliteal pterygium (HP:0009756)1.63245420
166Flexion contracture of toe (HP:0005830)1.61508439
167Joint contractures involving the joints of the feet (HP:0100492)1.61508439
168Aplasia involving bones of the extremities (HP:0009825)1.60696278
169Aplasia involving bones of the upper limbs (HP:0009823)1.60696278
170Aplasia of the phalanges of the hand (HP:0009802)1.60696278
171Leiomyosarcoma (HP:0100243)1.60278265
172Uterine leiomyosarcoma (HP:0002891)1.60278265
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59556951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.92900543
2STK243.97698436
3ERN13.00674580
4TTN2.87499592
5PKN22.87491392
6RIPK12.78851717
7PRPF4B2.70230973
8EPHB22.57544622
9ICK2.55749010
10PDGFRA2.04520298
11SIK12.03736625
12BCKDK1.96792934
13MAP3K101.90306126
14PTK61.85449035
15IRAK31.85282146
16DDR21.82817124
17LATS11.79597091
18JAK31.77938837
19PRKD31.76123386
20FGFR41.75390866
21LMTK21.74519715
22PDK41.71906856
23PDK31.71906856
24LATS21.65151265
25TYRO31.60376957
26EPHB11.59076436
27SMG11.58855149
28PHKG21.55664219
29PHKG11.55664219
30DMPK1.48098332
31CDK121.44307331
32KSR21.37165244
33BMX1.35981044
34TESK11.31430406
35RPS6KA21.31382319
36RPS6KC11.30558684
37RPS6KL11.30558684
38CCNB11.30094490
39EEF2K1.24369991
40TAOK31.23681415
41PTK2B1.13597903
42PTK21.10614106
43TAOK11.09817562
44MARK21.09472543
45RPS6KA61.09360840
46DYRK1B1.08032265
47LRRK21.06567463
48CAMK1G1.06099784
49PAK31.05827314
50FGFR21.05212296
51RIPK41.01253474
52RET1.00475258
53WNK41.00087521
54ILK0.95537956
55TAOK20.95480404
56TGFBR20.95464942
57PDK20.94412533
58CDC42BPA0.93514640
59PAK60.93010670
60MAPKAPK30.92522023
61CAMK1D0.90550451
62PAK40.88709749
63CAMK40.87523923
64MST1R0.87419253
65MET0.85374176
66MTOR0.84259543
67PRKD10.81388680
68PRKD20.80480663
69NTRK10.79941409
70SGK30.79905242
71ZAP700.79830854
72OBSCN0.79532721
73FER0.79445828
74PAK20.77850996
75PINK10.77565828
76MAP3K130.76774168
77PDGFRB0.75865321
78TRPM70.75733719
79SIK20.73683542
80TIE10.73461430
81CAMK10.73102756
82MAP3K70.72982938
83PDPK10.72846299
84NTRK20.71710799
85EPHA20.70040242
86MAPK120.68944156
87ARAF0.68072152
88MAP2K10.67430489
89IRAK40.65118432
90MAP3K60.64798424
91MAP2K30.64675501
92MAP3K20.64289557
93ROCK10.64064276
94MAP3K110.62871496
95MYLK0.62598034
96STK390.61788502
97STK380.60942338
98MAP3K90.60916592
99FGFR30.60009079
100MAP2K20.59774753
101HIPK20.58892401
102MAP3K30.58311910
103CAMKK10.58138782
104HCK0.57195018
105FGFR10.56780322
106CDK60.56709217
107PRKCH0.56694827
108EPHA30.55979045
109GSK3A0.55871542
110ERBB20.55657761
111TBK10.55449840
112PRKAA20.55280530
113MAP3K10.54607581
114TYK20.53777954
115WNK10.52609022
116CSK0.52605386
117MAP2K40.52138088
118PRKAA10.50916999
119NEK90.50432334
120PDK10.48176323
121TNK20.47978291
122SIK30.47375684
123MOS0.46489745
124JAK10.46127216
125DAPK30.45418209
126JAK20.44702944
127CDK90.42089924
128MAPK110.40482535
129STK30.40177567
130KSR10.40013233
131ERBB40.39856094
132LIMK10.39796697
133STK110.38241586
134SGK4940.37230523
135SGK2230.37230523
136PRKG20.36659005
137PRKCZ0.36460035
138DAPK20.36367621
139KDR0.36248830
140ROCK20.35836234
141PIK3CG0.35613897
142SGK20.34062727
143IRAK20.33896287
144MAPKAPK20.31683770

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.57494522
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88228303
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.54589537
4Fatty acid degradation_Homo sapiens_hsa000712.48395432
5Arginine biosynthesis_Homo sapiens_hsa002202.38597167
6PPAR signaling pathway_Homo sapiens_hsa033202.29881297
7Propanoate metabolism_Homo sapiens_hsa006402.14172192
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08917138
9Fatty acid metabolism_Homo sapiens_hsa012122.07485292
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02575597
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94269459
12Complement and coagulation cascades_Homo sapiens_hsa046101.90187088
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85480355
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83936613
15Tryptophan metabolism_Homo sapiens_hsa003801.83793543
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75345275
17Butanoate metabolism_Homo sapiens_hsa006501.59208406
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.53574728
19Caffeine metabolism_Homo sapiens_hsa002321.52346452
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49485547
21Bile secretion_Homo sapiens_hsa049761.48818085
22Pyruvate metabolism_Homo sapiens_hsa006201.46974033
23Notch signaling pathway_Homo sapiens_hsa043301.45203136
24Acute myeloid leukemia_Homo sapiens_hsa052211.44008155
25Other glycan degradation_Homo sapiens_hsa005111.43487613
26Staphylococcus aureus infection_Homo sapiens_hsa051501.43408013
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38569067
28Osteoclast differentiation_Homo sapiens_hsa043801.36112214
29Non-small cell lung cancer_Homo sapiens_hsa052231.34729567
30Fat digestion and absorption_Homo sapiens_hsa049751.31095766
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29783250
32Fatty acid biosynthesis_Homo sapiens_hsa000611.29507546
33B cell receptor signaling pathway_Homo sapiens_hsa046621.29324927
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27228968
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23453980
36Carbon metabolism_Homo sapiens_hsa012001.22932062
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20063864
38Pancreatic cancer_Homo sapiens_hsa052121.19576897
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.13224165
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.12717015
41Peroxisome_Homo sapiens_hsa041461.11544132
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10771837
43ErbB signaling pathway_Homo sapiens_hsa040121.09846890
44beta-Alanine metabolism_Homo sapiens_hsa004101.09502010
45Endocytosis_Homo sapiens_hsa041441.03988513
46Insulin resistance_Homo sapiens_hsa049311.03441474
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.02144985
48Starch and sucrose metabolism_Homo sapiens_hsa005000.99793205
49GnRH signaling pathway_Homo sapiens_hsa049120.99311556
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97979519
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97506088
52Phenylalanine metabolism_Homo sapiens_hsa003600.97161020
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96313624
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96275248
55Prolactin signaling pathway_Homo sapiens_hsa049170.94423288
56Thyroid cancer_Homo sapiens_hsa052160.93552033
57Choline metabolism in cancer_Homo sapiens_hsa052310.92590578
58Malaria_Homo sapiens_hsa051440.92326301
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92100420
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91615232
61TNF signaling pathway_Homo sapiens_hsa046680.90830783
62Chemical carcinogenesis_Homo sapiens_hsa052040.90614660
63Histidine metabolism_Homo sapiens_hsa003400.89260246
64Focal adhesion_Homo sapiens_hsa045100.88191521
65Lysine degradation_Homo sapiens_hsa003100.87969549
66Biosynthesis of amino acids_Homo sapiens_hsa012300.87278604
67Sulfur metabolism_Homo sapiens_hsa009200.87082822
68Leishmaniasis_Homo sapiens_hsa051400.86738757
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85436664
70Dilated cardiomyopathy_Homo sapiens_hsa054140.84792351
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84660729
72Glycerolipid metabolism_Homo sapiens_hsa005610.84552098
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84105325
74Hepatitis C_Homo sapiens_hsa051600.83380598
75AMPK signaling pathway_Homo sapiens_hsa041520.83331646
76Chemokine signaling pathway_Homo sapiens_hsa040620.82784250
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82227057
78Prostate cancer_Homo sapiens_hsa052150.81292648
79Hepatitis B_Homo sapiens_hsa051610.80663617
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80500461
81ECM-receptor interaction_Homo sapiens_hsa045120.79548061
82Toxoplasmosis_Homo sapiens_hsa051450.79484273
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78979348
84Rap1 signaling pathway_Homo sapiens_hsa040150.78886231
85Selenocompound metabolism_Homo sapiens_hsa004500.78036890
86FoxO signaling pathway_Homo sapiens_hsa040680.77373078
87Amoebiasis_Homo sapiens_hsa051460.76947864
88Tuberculosis_Homo sapiens_hsa051520.76782717
89Platelet activation_Homo sapiens_hsa046110.76661493
90Long-term potentiation_Homo sapiens_hsa047200.75806368
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75790465
92Insulin signaling pathway_Homo sapiens_hsa049100.75448795
93Tyrosine metabolism_Homo sapiens_hsa003500.75412469
94MAPK signaling pathway_Homo sapiens_hsa040100.75407332
95Pertussis_Homo sapiens_hsa051330.73859721
96Salmonella infection_Homo sapiens_hsa051320.73484941
97Phagosome_Homo sapiens_hsa041450.73367262
98Arginine and proline metabolism_Homo sapiens_hsa003300.72829993
99Lysosome_Homo sapiens_hsa041420.72479623
100Proteoglycans in cancer_Homo sapiens_hsa052050.71570691
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.70393873
102Colorectal cancer_Homo sapiens_hsa052100.70303951
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69809717
104Dorso-ventral axis formation_Homo sapiens_hsa043200.69764850
105Glucagon signaling pathway_Homo sapiens_hsa049220.69653787
106Prion diseases_Homo sapiens_hsa050200.68284850
107Inositol phosphate metabolism_Homo sapiens_hsa005620.67652175
108Axon guidance_Homo sapiens_hsa043600.66942802
109T cell receptor signaling pathway_Homo sapiens_hsa046600.65280264
110MicroRNAs in cancer_Homo sapiens_hsa052060.64953287
111Bladder cancer_Homo sapiens_hsa052190.63700718
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.62859603
113Adherens junction_Homo sapiens_hsa045200.62486121
114HIF-1 signaling pathway_Homo sapiens_hsa040660.61269295
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61129734
116Long-term depression_Homo sapiens_hsa047300.61084948
117Oxytocin signaling pathway_Homo sapiens_hsa049210.61049909
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60915990
119mTOR signaling pathway_Homo sapiens_hsa041500.60675969
120Fatty acid elongation_Homo sapiens_hsa000620.60670823
121Melanogenesis_Homo sapiens_hsa049160.60342892
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59661326
123Influenza A_Homo sapiens_hsa051640.58695614
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58489680
125Measles_Homo sapiens_hsa051620.57098101
126VEGF signaling pathway_Homo sapiens_hsa043700.57092086
127Retinol metabolism_Homo sapiens_hsa008300.57070411
128Pathways in cancer_Homo sapiens_hsa052000.56817801
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56743035
130Apoptosis_Homo sapiens_hsa042100.56661897
131ABC transporters_Homo sapiens_hsa020100.54719616
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53921712
133Chronic myeloid leukemia_Homo sapiens_hsa052200.52483231
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50453418
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50320956
136Protein digestion and absorption_Homo sapiens_hsa049740.49500392
137Renal cell carcinoma_Homo sapiens_hsa052110.48219767
138Tight junction_Homo sapiens_hsa045300.47394352
139Sulfur relay system_Homo sapiens_hsa041220.45720830
140Viral myocarditis_Homo sapiens_hsa054160.45142643
141Basal cell carcinoma_Homo sapiens_hsa052170.39111515
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38898840
143Hippo signaling pathway_Homo sapiens_hsa043900.38780753
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.38088995
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37478027
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36533786
147Glioma_Homo sapiens_hsa052140.36403628
148Endometrial cancer_Homo sapiens_hsa052130.36184042
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35609930
150Cardiac muscle contraction_Homo sapiens_hsa042600.34823198
151Type II diabetes mellitus_Homo sapiens_hsa049300.34681412
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.34577358
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34319407
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.33290458
155Hedgehog signaling pathway_Homo sapiens_hsa043400.32929454
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.32902730
157Estrogen signaling pathway_Homo sapiens_hsa049150.32525307
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30705139
159Small cell lung cancer_Homo sapiens_hsa052220.29739739
160Pentose phosphate pathway_Homo sapiens_hsa000300.29527229

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