ZFAND4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.78236870
2sperm motility (GO:0030317)7.60473535
3fusion of sperm to egg plasma membrane (GO:0007342)7.44859497
4axonemal dynein complex assembly (GO:0070286)6.64276778
5sperm-egg recognition (GO:0035036)6.37562235
6acrosome reaction (GO:0007340)6.05356410
7cell wall macromolecule catabolic process (GO:0016998)6.03885637
8cell wall macromolecule metabolic process (GO:0044036)6.03885637
9acrosome assembly (GO:0001675)6.01036780
10binding of sperm to zona pellucida (GO:0007339)5.90208800
11epithelial cilium movement (GO:0003351)5.87893056
12multicellular organism reproduction (GO:0032504)5.87302459
13cell-cell recognition (GO:0009988)5.79546644
14piRNA metabolic process (GO:0034587)5.58220053
15plasma membrane fusion (GO:0045026)5.51695684
16cilium movement (GO:0003341)5.48315527
17spermatid development (GO:0007286)5.38309544
18L-phenylalanine catabolic process (GO:0006559)5.37565899
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37565899
20male meiosis (GO:0007140)5.30754249
21motile cilium assembly (GO:0044458)5.26764191
22establishment of protein localization to Golgi (GO:0072600)5.15410438
23aromatic amino acid family catabolic process (GO:0009074)5.11898747
24centriole replication (GO:0007099)5.04497716
25protein polyglutamylation (GO:0018095)5.03535108
26L-phenylalanine metabolic process (GO:0006558)4.98058446
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.98058446
28reproduction (GO:0000003)4.97735053
29protein targeting to Golgi (GO:0000042)4.94282071
30indole-containing compound catabolic process (GO:0042436)4.91092763
31indolalkylamine catabolic process (GO:0046218)4.91092763
32tryptophan catabolic process (GO:0006569)4.91092763
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.82550920
34synaptonemal complex organization (GO:0070193)4.78180910
35retrograde transport, vesicle recycling within Golgi (GO:0000301)4.62245464
36synaptonemal complex assembly (GO:0007130)4.61967144
37urea cycle (GO:0000050)4.59410265
38urea metabolic process (GO:0019627)4.59410265
39bile acid biosynthetic process (GO:0006699)4.58279839
40kynurenine metabolic process (GO:0070189)4.54526383
41tryptophan metabolic process (GO:0006568)4.53863288
42regulation of cilium movement (GO:0003352)4.44004443
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43876968
44single strand break repair (GO:0000012)4.43104785
45alpha-linolenic acid metabolic process (GO:0036109)4.38049246
46response to pheromone (GO:0019236)4.27224506
47protein K11-linked deubiquitination (GO:0035871)4.25189150
48complement activation, alternative pathway (GO:0006957)4.23700175
49nitrogen cycle metabolic process (GO:0071941)4.22107780
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.18552509
51disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.14606181
52killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.14606181
53sulfur amino acid catabolic process (GO:0000098)4.13890324
54glyoxylate metabolic process (GO:0046487)4.11924979
55single fertilization (GO:0007338)4.09100197
56negative regulation of fibrinolysis (GO:0051918)4.08426353
57rRNA methylation (GO:0031167)4.03693000
58cysteine metabolic process (GO:0006534)4.01388297
59regulation of protein activation cascade (GO:2000257)4.00309427
60organic cation transport (GO:0015695)3.98110661
61high-density lipoprotein particle remodeling (GO:0034375)3.91863324
62regulation of fibrinolysis (GO:0051917)3.91379278
63cellular ketone body metabolic process (GO:0046950)3.90335536
64centriole assembly (GO:0098534)3.88429557
65neural tube formation (GO:0001841)3.83207159
66protein localization to Golgi apparatus (GO:0034067)3.83092382
67sperm capacitation (GO:0048240)3.81625134
68regulation of triglyceride catabolic process (GO:0010896)3.81149328
69male meiosis I (GO:0007141)3.80778274
70amino-acid betaine metabolic process (GO:0006577)3.75754566
71regulation of complement activation (GO:0030449)3.74617785
72imidazole-containing compound metabolic process (GO:0052803)3.74298804
73bile acid metabolic process (GO:0008206)3.74145051
74axoneme assembly (GO:0035082)3.73038746
75lysine catabolic process (GO:0006554)3.67043288
76lysine metabolic process (GO:0006553)3.67043288
77microtubule nucleation (GO:0007020)3.65680013
78RNA destabilization (GO:0050779)3.62573400
79serine family amino acid catabolic process (GO:0009071)3.59606820
80ketone body metabolic process (GO:1902224)3.59278169
81DNA methylation involved in gamete generation (GO:0043046)3.56550676
82peptidyl-glutamic acid carboxylation (GO:0017187)3.54179472
83protein carboxylation (GO:0018214)3.54179472
84aromatic amino acid family metabolic process (GO:0009072)3.52995489
85interkinetic nuclear migration (GO:0022027)3.51940489
86fertilization (GO:0009566)3.47404598
87blood coagulation, intrinsic pathway (GO:0007597)3.45603561
88chromosome organization involved in meiosis (GO:0070192)3.44202766
89glycine metabolic process (GO:0006544)3.43898424
90disruption of cells of other organism (GO:0044364)3.42460945
91killing of cells of other organism (GO:0031640)3.42460945
92plasma lipoprotein particle remodeling (GO:0034369)3.40631665
93protein-lipid complex remodeling (GO:0034368)3.40631665
94macromolecular complex remodeling (GO:0034367)3.40631665
95alpha-amino acid catabolic process (GO:1901606)3.36797796
96spermatid nucleus differentiation (GO:0007289)3.36123215
97bile acid and bile salt transport (GO:0015721)3.35782667
98coenzyme catabolic process (GO:0009109)3.34773941
99spermatogenesis (GO:0007283)3.33996153
100male gamete generation (GO:0048232)3.33106854
101indolalkylamine metabolic process (GO:0006586)3.33069398
102regulation of meiosis I (GO:0060631)3.31881932
103reverse cholesterol transport (GO:0043691)3.29520375
104protein K48-linked deubiquitination (GO:0071108)3.29443094
105regulation of centriole replication (GO:0046599)3.27571998
106nicotinamide nucleotide biosynthetic process (GO:0019359)3.27010119
107pyridine nucleotide biosynthetic process (GO:0019363)3.27010119
108phosphatidylethanolamine metabolic process (GO:0046337)3.26610706
109meiotic nuclear division (GO:0007126)3.24162172
110homocysteine metabolic process (GO:0050667)3.23418460
111phosphatidylethanolamine biosynthetic process (GO:0006646)3.23148842
112microtubule depolymerization (GO:0007019)3.22467733
113regulation of cholesterol esterification (GO:0010872)3.21984935
114amine catabolic process (GO:0009310)3.21778944
115cellular biogenic amine catabolic process (GO:0042402)3.21778944
116serine family amino acid metabolic process (GO:0009069)3.19998375
117microtubule polymerization or depolymerization (GO:0031109)3.19301043
118glycerol ether metabolic process (GO:0006662)3.17989498
119NAD biosynthetic process (GO:0009435)3.17601705
120tyrosine metabolic process (GO:0006570)3.16405737
121serine family amino acid biosynthetic process (GO:0009070)3.15480026
122histone H3-K9 methylation (GO:0051567)3.14858629
123meiosis I (GO:0007127)3.14578429
124ethanol oxidation (GO:0006069)3.14424528
125cilium organization (GO:0044782)3.14172745
126regulation of microtubule-based movement (GO:0060632)3.14088452
127rRNA modification (GO:0000154)3.13782758
128plasma lipoprotein particle assembly (GO:0034377)3.13577540
129negative regulation of cholesterol transport (GO:0032375)3.12803979
130gamete generation (GO:0007276)3.08064190
131cilium assembly (GO:0042384)3.07373381
132protein K63-linked deubiquitination (GO:0070536)3.04045612
133spinal cord motor neuron differentiation (GO:0021522)2.96050754
134behavioral response to nicotine (GO:0035095)2.94902422
135histone H3-K9 modification (GO:0061647)2.94752521
136negative regulation of inclusion body assembly (GO:0090084)2.94327862
137histone mRNA catabolic process (GO:0071044)2.94122561
138phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.92435955
139DNA packaging (GO:0006323)2.92004272
140regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.90562333
141positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.90562333
142photoreceptor cell maintenance (GO:0045494)2.89935161
143seminiferous tubule development (GO:0072520)2.89577854
144rRNA catabolic process (GO:0016075)2.89560007
145histone H3-K4 trimethylation (GO:0080182)2.89424529
146synapsis (GO:0007129)2.86585689
147L-fucose metabolic process (GO:0042354)2.86566979
148L-fucose catabolic process (GO:0042355)2.86566979
149fucose catabolic process (GO:0019317)2.86566979
150peptidyl-lysine trimethylation (GO:0018023)2.85117401
151histone H3-K36 demethylation (GO:0070544)2.82506999
152reciprocal DNA recombination (GO:0035825)2.82279686
153reciprocal meiotic recombination (GO:0007131)2.82279686
154calcium ion-dependent exocytosis (GO:0017156)2.81939411
155Golgi to endosome transport (GO:0006895)2.81600961
156regulation of Rab GTPase activity (GO:0032313)2.77893619
157positive regulation of Rab GTPase activity (GO:0032851)2.77893619
158microtubule severing (GO:0051013)2.73118869
159mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.72772540
160positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.72772540
161peptidyl-threonine dephosphorylation (GO:0035970)2.71621246
162negative regulation of translation, ncRNA-mediated (GO:0040033)2.67561378
163regulation of translation, ncRNA-mediated (GO:0045974)2.67561378
164negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67561378
165activated T cell proliferation (GO:0050798)2.65681556
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.64534099
167retinal cone cell development (GO:0046549)2.64098386
168positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60982717
169regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60982717
170sister chromatid cohesion (GO:0007062)2.57431103
171tachykinin receptor signaling pathway (GO:0007217)2.53033557
172peptidyl-lysine methylation (GO:0018022)2.50505508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.07319613
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.75538369
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.11505244
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.71873361
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.17018695
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.84981533
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50133582
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.47367075
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29537167
10E2F7_22180533_ChIP-Seq_HELA_Human3.06537870
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99484107
12ZNF274_21170338_ChIP-Seq_K562_Hela2.89428871
13FUS_26573619_Chip-Seq_HEK293_Human2.80968026
14VDR_22108803_ChIP-Seq_LS180_Human2.79375231
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69912203
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63579414
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40729126
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.36534232
19GBX2_23144817_ChIP-Seq_PC3_Human2.26235889
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16718296
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13775401
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.11394308
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11394308
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06540668
25ER_23166858_ChIP-Seq_MCF-7_Human2.04250148
26P300_19829295_ChIP-Seq_ESCs_Human2.02907888
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01729494
28IGF1R_20145208_ChIP-Seq_DFB_Human1.98593564
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95906888
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90211721
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86408212
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.83248264
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77262478
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77015036
35STAT3_23295773_ChIP-Seq_U87_Human1.76201999
36EWS_26573619_Chip-Seq_HEK293_Human1.75046905
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.73858012
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70565972
39SCL_19346495_ChIP-Seq_HPC-7_Human1.67274071
40SMAD4_21799915_ChIP-Seq_A2780_Human1.63438579
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60184944
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58911700
43AR_21572438_ChIP-Seq_LNCaP_Human1.57943651
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57389690
45TCF4_23295773_ChIP-Seq_U87_Human1.52255592
46AR_25329375_ChIP-Seq_VCAP_Human1.50617153
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49900331
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47415587
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.47275794
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47142804
51STAT1_17558387_ChIP-Seq_HELA_Human1.46970418
52BCAT_22108803_ChIP-Seq_LS180_Human1.45864892
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43834348
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39954975
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.38966795
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.38278599
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.36563433
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.35415444
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.34510633
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.33635801
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33475631
62EZH2_22144423_ChIP-Seq_EOC_Human1.32295568
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31817083
64RUNX2_22187159_ChIP-Seq_PCA_Human1.31318774
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31199047
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.31041486
67NANOG_19829295_ChIP-Seq_ESCs_Human1.29835272
68SOX2_19829295_ChIP-Seq_ESCs_Human1.29835272
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28511578
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28364309
71TP53_22573176_ChIP-Seq_HFKS_Human1.28297508
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.27529482
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27512947
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26210990
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24614297
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.24565247
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24445259
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23294274
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23041256
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.22363871
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22334231
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21515254
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21485086
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20629170
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20333157
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19553204
87ETV1_20927104_ChIP-Seq_GIST48_Human1.18893052
88TCF4_22108803_ChIP-Seq_LS180_Human1.18880235
89GATA1_22025678_ChIP-Seq_K562_Human1.18839993
90RUNX_20019798_ChIP-Seq_JUKART_Human1.18181541
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17444078
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17289410
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17272762
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15652119
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15244450
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13394742
97TBL1_22424771_ChIP-Seq_293T_Human1.13274352
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13071871
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.12960620
100CDX2_22108803_ChIP-Seq_LS180_Human1.12457690
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.11994036
102P53_22387025_ChIP-Seq_ESCs_Mouse1.11746962
103NFYB_21822215_ChIP-Seq_K562_Human1.11091259
104SMRT_27268052_Chip-Seq_Bcells_Human1.09823191
105HTT_18923047_ChIP-ChIP_STHdh_Human1.09719223
106GATA3_26560356_Chip-Seq_TH2_Human1.09520122
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09319498
108GATA3_21867929_ChIP-Seq_CD8_Mouse1.09211307
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.08381298
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08381298
111P53_21459846_ChIP-Seq_SAOS-2_Human1.07192151
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05693954
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05080767
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04694858
115RARA_24833708_ChIP-Seq_LIVER_Mouse1.04140637
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03795385
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03755289
118RBPJ_21746931_ChIP-Seq_IB4_Human1.03741550
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.03652270
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03292808
121SALL4_22934838_ChIP-ChIP_CD34+_Human1.03204123
122CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03095756
123GATA3_21867929_ChIP-Seq_TH1_Mouse1.02970508
124PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02915167
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02780583
126IRF1_19129219_ChIP-ChIP_H3396_Human1.02206345
127P300_18555785_Chip-Seq_ESCs_Mouse1.02199462
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02118251
129ERG_20517297_ChIP-Seq_VCAP_Human1.01733292
130FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01601496
131NFYA_21822215_ChIP-Seq_K562_Human0.99946442
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99935273
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97515717
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96204113
135E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95908361
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.95443502
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94707693
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92436975
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92128601
140IRF8_27001747_Chip-Seq_BMDM_Mouse0.91755152
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.91653394
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89893078
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89473824
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89365894
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88098347
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87970406
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87652257
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.87431321
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.87215268
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.87100611
151SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87054639
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.86897513
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85730137
154GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85237229
155RARB_24833708_ChIP-Seq_LIVER_Mouse0.84291371
156GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.84245843
157TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84191858
158FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83968360
159IRF8_21731497_ChIP-ChIP_J774_Mouse0.83567892
160KDM2B_26808549_Chip-Seq_REH_Human0.82980887
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82858745
162PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80863756
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80308591
164CEBPB_22108803_ChIP-Seq_LS180_Human0.80201302
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80008993
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79924424
167CBP_20019798_ChIP-Seq_JUKART_Human0.79924424
168SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79589205
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79455163
170Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79238312
171LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.78553852
172AR_20517297_ChIP-Seq_VCAP_Human0.77616203
173HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77158072
174TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77008463
175CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76844307
176OCT4_18555785_Chip-Seq_ESCs_Mouse0.76635973
177MYB_26560356_Chip-Seq_TH1_Human0.76096298
178CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76041465
179TAF15_26573619_Chip-Seq_HEK293_Human0.75810393
180ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75442603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.30672511
2MP0002139_abnormal_hepatobiliary_system6.71185923
3MP0005360_urolithiasis5.70215200
4MP0005365_abnormal_bile_salt4.91402792
5MP0005085_abnormal_gallbladder_physiolo4.90604551
6MP0000569_abnormal_digit_pigmentation4.18685756
7MP0008875_abnormal_xenobiotic_pharmacok3.97165764
8MP0003806_abnormal_nucleotide_metabolis3.76469311
9MP0003787_abnormal_imprinting3.61355168
10MP0003252_abnormal_bile_duct3.08353958
11MP0003698_abnormal_male_reproductive2.87909824
12MP0001929_abnormal_gametogenesis2.84098178
13MP0008877_abnormal_DNA_methylation2.80304490
14MP0010329_abnormal_lipoprotein_level2.76819779
15MP0005310_abnormal_salivary_gland2.13013435
16MP0003646_muscle_fatigue2.04133928
17MP0001764_abnormal_homeostasis2.02662984
18MP0005083_abnormal_biliary_tract2.01141217
19MP0003878_abnormal_ear_physiology2.01020707
20MP0005377_hearing/vestibular/ear_phenot2.01020707
21MP0002210_abnormal_sex_determination1.93052396
22MP0005645_abnormal_hypothalamus_physiol1.91502790
23MP0002138_abnormal_hepatobiliary_system1.89216265
24MP0005332_abnormal_amino_acid1.84752755
25MP0005551_abnormal_eye_electrophysiolog1.76363651
26MP0005253_abnormal_eye_physiology1.75053906
27MP0002102_abnormal_ear_morphology1.72886023
28MP0009840_abnormal_foam_cell1.72524154
29MP0001666_abnormal_nutrient_absorption1.71202489
30MP0000609_abnormal_liver_physiology1.70824599
31MP0009697_abnormal_copulation1.68123208
32MP0004742_abnormal_vestibular_system1.66417029
33MP0002161_abnormal_fertility/fecundity1.62162266
34MP0001145_abnormal_male_reproductive1.61709155
35MP0001968_abnormal_touch/_nociception1.60859084
36MP0003121_genomic_imprinting1.59078891
37MP0001986_abnormal_taste_sensitivity1.58371553
38MP0005319_abnormal_enzyme/_coenzyme1.57016792
39MP0005397_hematopoietic_system_phenotyp1.56218622
40MP0001545_abnormal_hematopoietic_system1.56218622
41MP0008995_early_reproductive_senescence1.54919664
42MP0004019_abnormal_vitamin_homeostasis1.53637534
43MP0002118_abnormal_lipid_homeostasis1.52508602
44MP0005379_endocrine/exocrine_gland_phen1.52484243
45MP0003868_abnormal_feces_composition1.52144991
46MP0003195_calcinosis1.51596060
47MP0003656_abnormal_erythrocyte_physiolo1.48386378
48MP0000653_abnormal_sex_gland1.48347913
49MP0003191_abnormal_cellular_cholesterol1.48113127
50MP0003718_maternal_effect1.41136056
51MP0002163_abnormal_gland_morphology1.40928370
52MP0005647_abnormal_sex_gland1.40706714
53MP0001984_abnormal_olfaction1.36616763
54MP0005584_abnormal_enzyme/coenzyme_acti1.34328096
55MP0006072_abnormal_retinal_apoptosis1.32151899
56MP0008057_abnormal_DNA_replication1.31204748
57MP0001485_abnormal_pinna_reflex1.29265871
58MP0006292_abnormal_olfactory_placode1.21376578
59MP0005464_abnormal_platelet_physiology1.17407868
60MP0003724_increased_susceptibility_to1.16600484
61MP0001486_abnormal_startle_reflex1.16479260
62MP0003436_decreased_susceptibility_to1.15885683
63MP0010094_abnormal_chromosome_stability1.15815949
64MP0003763_abnormal_thymus_physiology1.14877281
65MP0000598_abnormal_liver_morphology1.11596861
66MP0006036_abnormal_mitochondrial_physio1.10829628
67MP0000015_abnormal_ear_pigmentation1.10562702
68MP0002837_dystrophic_cardiac_calcinosis1.09570439
69MP0009763_increased_sensitivity_to1.09147454
70MP0002272_abnormal_nervous_system1.08683532
71MP0003011_delayed_dark_adaptation1.06734359
72MP0008469_abnormal_protein_level1.06559958
73MP0009785_altered_susceptibility_to1.04233680
74MP0009745_abnormal_behavioral_response1.03038150
75MP0009764_decreased_sensitivity_to1.01946375
76MP0002557_abnormal_social/conspecific_i1.01868704
77MP0004142_abnormal_muscle_tone1.01681954
78MP0000631_abnormal_neuroendocrine_gland1.00106574
79MP0003186_abnormal_redox_activity0.99207973
80MP0001501_abnormal_sleep_pattern0.98702957
81MP0002736_abnormal_nociception_after0.98214944
82MP0005636_abnormal_mineral_homeostasis0.97423470
83MP0000372_irregular_coat_pigmentation0.97222919
84MP0009278_abnormal_bone_marrow0.96851343
85MP0002928_abnormal_bile_duct0.95978579
86MP0002277_abnormal_respiratory_mucosa0.95465603
87MP0002067_abnormal_sensory_capabilities0.93801044
88MP0009046_muscle_twitch0.93452809
89MP0005671_abnormal_response_to0.92370870
90MP0002095_abnormal_skin_pigmentation0.92169850
91MP0005075_abnormal_melanosome_morpholog0.91694507
92MP0002693_abnormal_pancreas_physiology0.91120901
93MP0006276_abnormal_autonomic_nervous0.89716639
94MP0005670_abnormal_white_adipose0.89429798
95MP0003880_abnormal_central_pattern0.89165378
96MP0002160_abnormal_reproductive_system0.88703843
97MP0002229_neurodegeneration0.88483543
98MP0001835_abnormal_antigen_presentation0.84770919
99MP0008872_abnormal_physiological_respon0.83951783
100MP0004924_abnormal_behavior0.82848830
101MP0005386_behavior/neurological_phenoty0.82848830
102MP0008058_abnormal_DNA_repair0.82072856
103MP0005025_abnormal_response_to0.81748810
104MP0000685_abnormal_immune_system0.81293949
105MP0008961_abnormal_basal_metabolism0.78904587
106MP0005376_homeostasis/metabolism_phenot0.77694488
107MP0009642_abnormal_blood_homeostasis0.77124964
108MP0004808_abnormal_hematopoietic_stem0.77119013
109MP0004885_abnormal_endolymph0.76713538
110MP0005395_other_phenotype0.75996430
111MP0009643_abnormal_urine_homeostasis0.75430125
112MP0002009_preneoplasia0.74915770
113MP0002735_abnormal_chemical_nociception0.74009830
114MP0002419_abnormal_innate_immunity0.73874915
115MP0002638_abnormal_pupillary_reflex0.73309356
116MP0002653_abnormal_ependyma_morphology0.73072403
117MP0001853_heart_inflammation0.72624475
118MP0002572_abnormal_emotion/affect_behav0.72223300
119MP0003172_abnormal_lysosome_physiology0.71359700
120MP0000604_amyloidosis0.70615437
121MP0009765_abnormal_xenobiotic_induced0.70494063
122MP0005423_abnormal_somatic_nervous0.70073903
123MP0002132_abnormal_respiratory_system0.68928697
124MP0000465_gastrointestinal_hemorrhage0.68739023
125MP0002822_catalepsy0.68572956
126MP0005084_abnormal_gallbladder_morpholo0.68274969
127MP0002751_abnormal_autonomic_nervous0.68191230
128MP0009115_abnormal_fat_cell0.67421628
129MP0001970_abnormal_pain_threshold0.66599902
130MP0002282_abnormal_trachea_morphology0.65515383
131MP0005646_abnormal_pituitary_gland0.64930907
132MP0001944_abnormal_pancreas_morphology0.64817528
133MP0010386_abnormal_urinary_bladder0.64687533
134MP0000371_diluted_coat_color0.64568153
135MP0000703_abnormal_thymus_morphology0.64315100
136MP0004484_altered_response_of0.63516790
137MP0001188_hyperpigmentation0.63449229
138MP0002254_reproductive_system_inflammat0.63234537
139MP0002876_abnormal_thyroid_physiology0.62778779
140MP0000955_abnormal_spinal_cord0.62180869
141MP0005266_abnormal_metabolism0.61599059
142MP0006035_abnormal_mitochondrial_morpho0.61232354
143MP0001845_abnormal_inflammatory_respons0.60198936
144MP0000689_abnormal_spleen_morphology0.56955540
145MP0002166_altered_tumor_susceptibility0.56523767
146MP0002396_abnormal_hematopoietic_system0.56356555
147MP0001800_abnormal_humoral_immune0.56334807
148MP0002971_abnormal_brown_adipose0.56088196
149MP0000427_abnormal_hair_cycle0.53085142
150MP0005451_abnormal_body_composition0.51872390
151MP0003943_abnormal_hepatobiliary_system0.51787685
152MP0001119_abnormal_female_reproductive0.51644547
153MP0002723_abnormal_immune_serum0.50592021
154MP0008873_increased_physiological_sensi0.50529261
155MP0005389_reproductive_system_phenotype0.49727771
156MP0003699_abnormal_female_reproductive0.48575552
157MP0002398_abnormal_bone_marrow0.47608247
158MP0005334_abnormal_fat_pad0.46881070
159MP0001765_abnormal_ion_homeostasis0.46745322
160MP0005408_hypopigmentation0.46360231
161MP0004147_increased_porphyrin_level0.46118382
162MP0005174_abnormal_tail_pigmentation0.46056007
163MP0000639_abnormal_adrenal_gland0.46003864
164MP0002405_respiratory_system_inflammati0.44044876
165MP0000716_abnormal_immune_system0.42406185
166MP0002429_abnormal_blood_cell0.42134171
167MP0005220_abnormal_exocrine_pancreas0.42013423
168MP0001873_stomach_inflammation0.38887674

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.89534845
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.84867092
3Absent/shortened dynein arms (HP:0200106)7.84867092
4Abnormal respiratory motile cilium physiology (HP:0012261)6.76618767
5Abnormal respiratory motile cilium morphology (HP:0005938)6.21481762
6Abnormal respiratory epithelium morphology (HP:0012253)6.21481762
7Abnormal ciliary motility (HP:0012262)5.79077050
8Rhinitis (HP:0012384)5.53271066
9Deep venous thrombosis (HP:0002625)4.79760257
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.79021679
11Intrahepatic cholestasis (HP:0001406)4.71326136
12Nasal polyposis (HP:0100582)4.63130375
13Prolonged partial thromboplastin time (HP:0003645)4.53379134
14Chronic bronchitis (HP:0004469)4.51949936
15Abnormality of the nasal mucosa (HP:0000433)4.39584783
16Abnormality of monocarboxylic acid metabolism (HP:0010996)4.32173021
17Hypobetalipoproteinemia (HP:0003563)4.23858705
18Infertility (HP:0000789)4.16007560
19Pancreatic cysts (HP:0001737)3.74658620
20Complement deficiency (HP:0004431)3.67640751
21Hyperlipoproteinemia (HP:0010980)3.61601005
22Pancreatic fibrosis (HP:0100732)3.56346741
23Xanthomatosis (HP:0000991)3.52317843
24Bronchiectasis (HP:0002110)3.48925039
25Joint hemorrhage (HP:0005261)3.40597193
26Recurrent sinusitis (HP:0011108)3.30020137
27Abnormality of pyrimidine metabolism (HP:0004353)3.25500992
28True hermaphroditism (HP:0010459)3.22790435
29Epidermoid cyst (HP:0200040)3.17390588
30Bronchitis (HP:0012387)3.13706710
31Attenuation of retinal blood vessels (HP:0007843)3.02836495
32Abnormal spermatogenesis (HP:0008669)2.99626664
33Abnormal rod and cone electroretinograms (HP:0008323)2.93595040
34Hypolipoproteinemia (HP:0010981)2.91130069
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.88653487
36Hypercholesterolemia (HP:0003124)2.88639379
37Abnormality of the common coagulation pathway (HP:0010990)2.87088569
38Volvulus (HP:0002580)2.86833623
39Recurrent gram-negative bacterial infections (HP:0005420)2.85177684
40Abnormality of methionine metabolism (HP:0010901)2.82047475
41Fat malabsorption (HP:0002630)2.76880683
42Hyperammonemia (HP:0001987)2.76197416
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75935172
44Nephronophthisis (HP:0000090)2.75685294
45Abnormality of the intrinsic pathway (HP:0010989)2.74692266
46Spontaneous abortion (HP:0005268)2.65908816
47Abnormality of complement system (HP:0005339)2.65387580
48Ketosis (HP:0001946)2.64703293
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60035013
50Recurrent otitis media (HP:0000403)2.58807808
51Progressive cerebellar ataxia (HP:0002073)2.58458128
52Intestinal atresia (HP:0011100)2.56925282
53Hyperkalemia (HP:0002153)2.56896868
54Abnormal gallbladder physiology (HP:0012438)2.55253011
55Cholecystitis (HP:0001082)2.55253011
56Hyperventilation (HP:0002883)2.55048559
57Neoplasm of the adrenal cortex (HP:0100641)2.53911818
58Polydipsia (HP:0001959)2.53046290
59Abnormal drinking behavior (HP:0030082)2.53046290
60Azoospermia (HP:0000027)2.51416292
61Oligodactyly (hands) (HP:0001180)2.50739747
62Bony spicule pigmentary retinopathy (HP:0007737)2.49071666
63Hyperglycinemia (HP:0002154)2.48439204
64Hyperbilirubinemia (HP:0002904)2.47892069
65Male infertility (HP:0003251)2.47765435
66Truncal obesity (HP:0001956)2.47700983
67Type II lissencephaly (HP:0007260)2.47307342
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46048863
69Gaze-evoked nystagmus (HP:0000640)2.45865451
70Tubular atrophy (HP:0000092)2.43647490
71Abnormal biliary tract physiology (HP:0012439)2.43172642
72Bile duct proliferation (HP:0001408)2.43172642
73Thyroiditis (HP:0100646)2.41874946
74Medial flaring of the eyebrow (HP:0010747)2.40686821
75Tubulointerstitial nephritis (HP:0001970)2.39546091
76Cystic liver disease (HP:0006706)2.39428238
77Acanthocytosis (HP:0001927)2.37773850
78Hypoalphalipoproteinemia (HP:0003233)2.34632399
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.32381559
80Gonadotropin excess (HP:0000837)2.30835795
81Cone-rod dystrophy (HP:0000548)2.30699014
82Abnormality of macular pigmentation (HP:0008002)2.30539304
83Conjunctival telangiectasia (HP:0000524)2.29955227
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26702804
85Abnormality of fatty-acid metabolism (HP:0004359)2.26449113
86Vascular calcification (HP:0004934)2.26162106
87Anencephaly (HP:0002323)2.24374649
88Congenital stationary night blindness (HP:0007642)2.22137053
89Recurrent bronchitis (HP:0002837)2.21544559
90Steatorrhea (HP:0002570)2.20616755
91Abnormality of the lower motor neuron (HP:0002366)2.20266775
92Atonic seizures (HP:0010819)2.19911442
93Menstrual irregularities (HP:0000858)2.19346534
94Hemorrhage of the eye (HP:0011885)2.18511286
95Decreased central vision (HP:0007663)2.16008640
96Menorrhagia (HP:0000132)2.15046999
97Poikilocytosis (HP:0004447)2.11414698
98Abnormality of nucleobase metabolism (HP:0010932)2.09613967
99Gingival bleeding (HP:0000225)2.09528515
100Abnormality of glycine metabolism (HP:0010895)2.09456021
101Abnormality of serine family amino acid metabolism (HP:0010894)2.09456021
102Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06263660
103Conjugated hyperbilirubinemia (HP:0002908)2.06098210
104Severe visual impairment (HP:0001141)2.05723521
105Hyperglycinuria (HP:0003108)2.05578885
106Dialeptic seizures (HP:0011146)2.05042006
107Abnormality of the renal cortex (HP:0011035)2.04670467
108Abnormal pancreas size (HP:0012094)2.01976171
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01804092
110Renal cortical cysts (HP:0000803)2.00143938
111Fair hair (HP:0002286)1.99726206
112Protruding tongue (HP:0010808)1.99448986
113Absent speech (HP:0001344)1.98748571
114Abnormality of the renal medulla (HP:0100957)1.98136684
115Hypochromic microcytic anemia (HP:0004840)1.97864117
116Hypoplasia of the thymus (HP:0000778)1.97044055
117Hypoglycemic coma (HP:0001325)1.96604388
118Constricted visual fields (HP:0001133)1.96418916
119Thrombophlebitis (HP:0004418)1.93792295
120Febrile seizures (HP:0002373)1.92138409
121Cardiovascular calcification (HP:0011915)1.92110618
122Gait imbalance (HP:0002141)1.91954404
123Impulsivity (HP:0100710)1.91621418
124Epistaxis (HP:0000421)1.91076820
125Decreased circulating renin level (HP:0003351)1.90497462
126Abnormality of serum amino acid levels (HP:0003112)1.89683833
127Cerebellar dysplasia (HP:0007033)1.89665350
128Growth hormone deficiency (HP:0000824)1.89274326
129Postaxial foot polydactyly (HP:0001830)1.88767992
130Congenital primary aphakia (HP:0007707)1.86828311
131Poor coordination (HP:0002370)1.85020643
132Polyuria (HP:0000103)1.84622183
133Increased mean platelet volume (HP:0011877)1.83318711
134Upper motor neuron abnormality (HP:0002127)1.82993761
135Molar tooth sign on MRI (HP:0002419)1.82615551
136Abnormality of midbrain morphology (HP:0002418)1.82615551
137Abnormal platelet volume (HP:0011876)1.80977940
138Genital tract atresia (HP:0001827)1.79935788
139Absence seizures (HP:0002121)1.78632033
140Tented upper lip vermilion (HP:0010804)1.78202215
141Male pseudohermaphroditism (HP:0000037)1.77250400
142Sclerocornea (HP:0000647)1.76198573
143Spontaneous hematomas (HP:0007420)1.76021840
144Sloping forehead (HP:0000340)1.75262465
145Genetic anticipation (HP:0003743)1.74821636
146Abnormality of the pons (HP:0007361)1.74097328
147Abnormality of chromosome stability (HP:0003220)1.74072405
148Tubulointerstitial abnormality (HP:0001969)1.73803343
149Metabolic acidosis (HP:0001942)1.72553129
150Hypoplasia of the pons (HP:0012110)1.72433045
151Reduced antithrombin III activity (HP:0001976)1.72086196
152Pendular nystagmus (HP:0012043)1.71113223
153Optic nerve hypoplasia (HP:0000609)1.69714026
154Congenital hepatic fibrosis (HP:0002612)1.69147754
155Neonatal hypoglycemia (HP:0001998)1.68518399
156Gastrointestinal atresia (HP:0002589)1.68416589
157Drooling (HP:0002307)1.67967133
158Furrowed tongue (HP:0000221)1.67813714
159Spastic diplegia (HP:0001264)1.67169121
160Pulmonary embolism (HP:0002204)1.66691790
161Amyotrophic lateral sclerosis (HP:0007354)1.66249833
162Impaired proprioception (HP:0010831)1.65555458
163Vaginal atresia (HP:0000148)1.65289629
164Hepatoblastoma (HP:0002884)1.64170616
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.63550252
166Progressive inability to walk (HP:0002505)1.63308717
167Stomatitis (HP:0010280)1.62319444
168Nephrogenic diabetes insipidus (HP:0009806)1.62095433
169Generalized aminoaciduria (HP:0002909)1.61714996
170Lissencephaly (HP:0001339)1.61591272
171Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61589150
172Chronic hepatic failure (HP:0100626)1.61440145
173Elevated hepatic transaminases (HP:0002910)1.61349635
174Clumsiness (HP:0002312)1.61078294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.38732874
2PDK37.38732874
3FRK5.31192004
4PDK24.14830936
5TESK13.70163184
6BCKDK2.80652226
7ICK2.47007978
8TNIK2.25856969
9WNK32.24660391
10CDC72.23306155
11MAP4K22.18509676
12BMPR1B2.06459610
13NEK22.05572799
14ZAK2.04236265
15MKNK21.98722537
16BRD41.93023686
17CAMK1G1.81076916
18PTK2B1.78462298
19STK161.67112677
20ERN11.62624768
21CCNB11.61531895
22ADRBK21.56266473
23TEC1.55924752
24WEE11.55339519
25PRKD31.54507576
26STK38L1.54105772
27MAPK151.52919805
28CAMKK21.51815372
29PLK21.46647102
30NUAK11.42107032
31DYRK1B1.40930578
32TAOK31.40772812
33BTK1.34157185
34SIK11.33346657
35NLK1.32556131
36MAP3K41.31868607
37DYRK31.27566240
38TLK11.27248172
39MAP2K61.26270593
40MAPK131.23630277
41FLT31.22100624
42FGFR41.21140612
43GRK11.20939123
44PKN21.19456452
45WNK11.18451031
46TRPM71.14960026
47MAP4K11.11422446
48MAPK111.10598784
49AKT31.10274102
50PDK11.09793194
51CDK41.07139520
52FGFR21.03115856
53SGK21.02806801
54CAMK1D1.02726712
55MARK31.02040210
56OXSR11.01825805
57KIT0.99797787
58CSK0.99772909
59ATR0.97505579
60CSF1R0.97124032
61CDK60.93204561
62MKNK10.89544198
63IRAK40.88479604
64PASK0.87600908
65TYK20.85868332
66ERBB30.85650897
67NEK60.85609795
68BRSK20.84730057
69MAP2K30.84630283
70ACVR1B0.82652727
71NEK90.81306798
72PLK40.80027569
73CASK0.79088132
74PNCK0.77617638
75EEF2K0.76329434
76EIF2AK30.75779822
77TTK0.74575053
78KDR0.73800188
79CHEK20.73372586
80TBK10.72525141
81CDK30.72462237
82STK30.71976102
83MST40.67676192
84PRKCE0.67553007
85CLK10.66991648
86PLK30.66791703
87MAPK40.66372874
88ITK0.66272390
89SGK4940.64384782
90SGK2230.64384782
91VRK10.61313003
92BLK0.60688652
93PRKCG0.58920456
94DYRK20.58906576
95IRAK10.57656181
96TGFBR20.57201681
97PRKAA20.56951614
98ZAP700.54608943
99PAK30.54181993
100CAMK40.53244630
101JAK30.52962681
102MUSK0.52156803
103STK110.51962659
104TGFBR10.50902888
105CDK90.50807208
106SGK10.50325739
107IKBKB0.49730821
108PRKCZ0.48830210
109WNK40.48586748
110IKBKE0.48113521
111EPHA30.47536764
112RPS6KA50.47317512
113TRIM280.46924468
114HIPK20.46556451
115PRKG10.46337485
116PIK3CG0.45668069
117RPS6KB10.44675688
118SIK20.43756902
119PLK10.43562198
120CDK80.41239281
121STK100.40753226
122DYRK1A0.40028928
123RIPK40.39616817
124GRK60.39613678
125STK390.39023328
126EPHB10.38539021
127CSNK1D0.38200032
128MARK10.37978559
129MAP2K40.37456075
130SGK30.37189586
131PRKCQ0.37043127
132MAP3K20.36584969
133PRKCH0.36478288
134ERBB40.36150761
135CHEK10.35856168
136STK240.35605872
137SYK0.34415370
138PDPK10.33681845
139CDK70.33612850
140ATM0.33425732
141PIM10.33044863
142STK40.32437501
143TIE10.32425566
144FGR0.32008090
145MATK0.31877229
146INSRR0.31585186
147LYN0.31452792
148FES0.31441303
149JAK20.30663585
150STK380.29405030
151RPS6KA40.27930479
152CSNK2A10.27561235
153TESK20.24540198
154TXK0.23275500
155AURKB0.22603777
156PRKAA10.22573000
157CDK190.21445177
158PINK10.21311740
159PRKACG0.20392230
160ABL20.19905905
161MAP2K70.19712627

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35108189
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93371336
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65334216
4Complement and coagulation cascades_Homo sapiens_hsa046102.59459556
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52613357
6Propanoate metabolism_Homo sapiens_hsa006402.42431102
7Nitrogen metabolism_Homo sapiens_hsa009102.41535791
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34401896
9Fatty acid degradation_Homo sapiens_hsa000712.31971746
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30122595
11Vitamin B6 metabolism_Homo sapiens_hsa007502.29249927
12Tryptophan metabolism_Homo sapiens_hsa003802.27660056
13Selenocompound metabolism_Homo sapiens_hsa004502.26864178
14Olfactory transduction_Homo sapiens_hsa047402.25765363
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22678832
16Pyruvate metabolism_Homo sapiens_hsa006202.22672520
17Arginine biosynthesis_Homo sapiens_hsa002202.20538831
18Regulation of autophagy_Homo sapiens_hsa041402.19508166
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17240610
20Phototransduction_Homo sapiens_hsa047442.12116706
21Non-homologous end-joining_Homo sapiens_hsa034502.03335298
22Chemical carcinogenesis_Homo sapiens_hsa052042.02027049
23Peroxisome_Homo sapiens_hsa041461.98365356
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96752378
25PPAR signaling pathway_Homo sapiens_hsa033201.94126712
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.91308761
27Staphylococcus aureus infection_Homo sapiens_hsa051501.91097491
28Type I diabetes mellitus_Homo sapiens_hsa049401.84196438
29Primary immunodeficiency_Homo sapiens_hsa053401.82679891
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.80753314
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76149458
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74088465
33Taste transduction_Homo sapiens_hsa047421.72058274
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.71876112
35Retinol metabolism_Homo sapiens_hsa008301.69438264
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68304015
37Histidine metabolism_Homo sapiens_hsa003401.64188264
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64003472
39Caffeine metabolism_Homo sapiens_hsa002321.60796295
40Fatty acid metabolism_Homo sapiens_hsa012121.59823941
41Circadian rhythm_Homo sapiens_hsa047101.54728750
42Nicotine addiction_Homo sapiens_hsa050331.50475186
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47762304
44Butanoate metabolism_Homo sapiens_hsa006501.47659985
45Pentose phosphate pathway_Homo sapiens_hsa000301.47145431
46ABC transporters_Homo sapiens_hsa020101.43525549
47Allograft rejection_Homo sapiens_hsa053301.40400027
48Carbon metabolism_Homo sapiens_hsa012001.39326849
49beta-Alanine metabolism_Homo sapiens_hsa004101.36920829
50Biosynthesis of amino acids_Homo sapiens_hsa012301.35655852
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.33694172
52RNA polymerase_Homo sapiens_hsa030201.29004803
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28707642
54DNA replication_Homo sapiens_hsa030301.28474588
55RNA degradation_Homo sapiens_hsa030181.25403546
56Bile secretion_Homo sapiens_hsa049761.22055356
57Phenylalanine metabolism_Homo sapiens_hsa003601.19398459
58Fat digestion and absorption_Homo sapiens_hsa049751.13565991
59Morphine addiction_Homo sapiens_hsa050321.12944104
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10972930
61One carbon pool by folate_Homo sapiens_hsa006701.10533789
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10522463
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09558118
64Autoimmune thyroid disease_Homo sapiens_hsa053201.09183631
65Fatty acid biosynthesis_Homo sapiens_hsa000611.09090553
66Starch and sucrose metabolism_Homo sapiens_hsa005001.08209560
67Tyrosine metabolism_Homo sapiens_hsa003501.07872600
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05993264
69RNA transport_Homo sapiens_hsa030131.05260442
70Sulfur metabolism_Homo sapiens_hsa009201.03833672
71Glutathione metabolism_Homo sapiens_hsa004801.02829474
72Fatty acid elongation_Homo sapiens_hsa000621.02739800
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.02265178
74Graft-versus-host disease_Homo sapiens_hsa053321.01676922
75Type II diabetes mellitus_Homo sapiens_hsa049300.99393653
76T cell receptor signaling pathway_Homo sapiens_hsa046600.98899428
77Glycerolipid metabolism_Homo sapiens_hsa005610.98427689
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95181389
79Ether lipid metabolism_Homo sapiens_hsa005650.93770790
80Folate biosynthesis_Homo sapiens_hsa007900.92500887
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91943288
82Measles_Homo sapiens_hsa051620.91802637
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90290349
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90008378
85Serotonergic synapse_Homo sapiens_hsa047260.89601570
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87251148
87B cell receptor signaling pathway_Homo sapiens_hsa046620.87065230
88Mismatch repair_Homo sapiens_hsa034300.85948691
89Protein export_Homo sapiens_hsa030600.85341428
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.84946400
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82018317
92Asthma_Homo sapiens_hsa053100.81625637
93Fanconi anemia pathway_Homo sapiens_hsa034600.80102178
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79962745
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78973427
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77514162
97Inositol phosphate metabolism_Homo sapiens_hsa005620.76440234
98FoxO signaling pathway_Homo sapiens_hsa040680.75599017
99Lysine degradation_Homo sapiens_hsa003100.73987375
100Sulfur relay system_Homo sapiens_hsa041220.73623429
101Pyrimidine metabolism_Homo sapiens_hsa002400.70700428
102Calcium signaling pathway_Homo sapiens_hsa040200.70658424
103Insulin secretion_Homo sapiens_hsa049110.69284387
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67663628
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66708183
106Circadian entrainment_Homo sapiens_hsa047130.66218067
107GABAergic synapse_Homo sapiens_hsa047270.65854232
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64079646
109Glucagon signaling pathway_Homo sapiens_hsa049220.62559026
110Glutamatergic synapse_Homo sapiens_hsa047240.62554685
111Linoleic acid metabolism_Homo sapiens_hsa005910.61909076
112Homologous recombination_Homo sapiens_hsa034400.61797112
113Metabolic pathways_Homo sapiens_hsa011000.60535533
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59942562
115Steroid biosynthesis_Homo sapiens_hsa001000.59785947
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59770795
117Hedgehog signaling pathway_Homo sapiens_hsa043400.58940223
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58190878
119Vitamin digestion and absorption_Homo sapiens_hsa049770.56570685
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56034178
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54472285
122Ovarian steroidogenesis_Homo sapiens_hsa049130.53734726
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52681403
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51755610
125Systemic lupus erythematosus_Homo sapiens_hsa053220.51750827
126Base excision repair_Homo sapiens_hsa034100.51161430
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49641685
128Arginine and proline metabolism_Homo sapiens_hsa003300.48258810
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.48053974
130Fructose and mannose metabolism_Homo sapiens_hsa000510.45614170
131Salivary secretion_Homo sapiens_hsa049700.44301279
132Amphetamine addiction_Homo sapiens_hsa050310.43643201
133cAMP signaling pathway_Homo sapiens_hsa040240.43474789
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43291847
135Hematopoietic cell lineage_Homo sapiens_hsa046400.43156179
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.42306190
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.42261571
138Cholinergic synapse_Homo sapiens_hsa047250.41670859
139Long-term depression_Homo sapiens_hsa047300.40381655
140Renin secretion_Homo sapiens_hsa049240.39687971
141Alcoholism_Homo sapiens_hsa050340.39034892
142Purine metabolism_Homo sapiens_hsa002300.36290939
143Basal transcription factors_Homo sapiens_hsa030220.32258721
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.28369756
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27499879
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.19671009
147Nucleotide excision repair_Homo sapiens_hsa034200.17981563
148Cell cycle_Homo sapiens_hsa041100.14476402
149Galactose metabolism_Homo sapiens_hsa000520.14276974
150Insulin resistance_Homo sapiens_hsa049310.11330867
151N-Glycan biosynthesis_Homo sapiens_hsa005100.11007611
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10205825
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06863945
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06749307
155Antigen processing and presentation_Homo sapiens_hsa046120.04225579
156Legionellosis_Homo sapiens_hsa051340.00949292
157Arachidonic acid metabolism_Homo sapiens_hsa005900.00771499
158AMPK signaling pathway_Homo sapiens_hsa041520.00420265
159Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0236769
160Herpes simplex infection_Homo sapiens_hsa05168-0.0153302
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0130190

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