ZFAND6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.17294262
2synapsis (GO:0007129)5.06753161
3proteasome assembly (GO:0043248)4.82454717
4DNA double-strand break processing (GO:0000729)4.73924166
5CENP-A containing nucleosome assembly (GO:0034080)4.65595109
6regulation of meiosis I (GO:0060631)4.63891499
7chromatin remodeling at centromere (GO:0031055)4.61675262
8histone exchange (GO:0043486)4.32899370
9cullin deneddylation (GO:0010388)4.26624690
10piRNA metabolic process (GO:0034587)4.06541893
11resolution of meiotic recombination intermediates (GO:0000712)3.93745748
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82359045
13protein deneddylation (GO:0000338)3.80933143
14DNA replication-independent nucleosome assembly (GO:0006336)3.65803007
15DNA replication-independent nucleosome organization (GO:0034724)3.65803007
16neutrophil activation involved in immune response (GO:0002283)3.65157584
17platelet dense granule organization (GO:0060155)3.61009387
18ribosomal small subunit assembly (GO:0000028)3.49816566
19microtubule depolymerization (GO:0007019)3.48241033
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46832573
21regulation of mitotic spindle checkpoint (GO:1903504)3.46832573
22centriole replication (GO:0007099)3.41631526
23male meiosis I (GO:0007141)3.36072107
24DNA ligation (GO:0006266)3.35378220
25intraciliary transport (GO:0042073)3.33318280
26histone mRNA metabolic process (GO:0008334)3.32250683
27histone H2A acetylation (GO:0043968)3.28096667
28regulation of centriole replication (GO:0046599)3.23395653
29detection of bacterium (GO:0016045)3.22428592
30neural tube formation (GO:0001841)3.21812622
31DNA damage response, detection of DNA damage (GO:0042769)3.20644402
32detection of other organism (GO:0098543)3.19465601
33male meiosis (GO:0007140)3.13236800
34chromosome organization involved in meiosis (GO:0070192)3.12144590
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11306544
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09738706
37response to interferon-beta (GO:0035456)3.08102386
38protein K11-linked ubiquitination (GO:0070979)3.05293686
39regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.04730132
40preassembly of GPI anchor in ER membrane (GO:0016254)3.02319402
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.98503478
42DNA integration (GO:0015074)2.98334141
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.97988187
44L-phenylalanine catabolic process (GO:0006559)2.97295287
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97295287
46DNA catabolic process, exonucleolytic (GO:0000738)2.95933152
47epithelial cilium movement (GO:0003351)2.95221580
48attachment of spindle microtubules to kinetochore (GO:0008608)2.94912085
49regulation of RIG-I signaling pathway (GO:0039535)2.94114552
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92522685
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90940924
52phospholipid efflux (GO:0033700)2.90744797
53T-helper 1 type immune response (GO:0042088)2.90309550
54meiosis I (GO:0007127)2.90161944
55growth hormone receptor signaling pathway (GO:0060396)2.89913645
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88963935
57positive regulation of mitochondrial fission (GO:0090141)2.88084302
58negative regulation of DNA recombination (GO:0045910)2.87995505
59polyketide metabolic process (GO:0030638)2.86480482
60doxorubicin metabolic process (GO:0044598)2.86480482
61daunorubicin metabolic process (GO:0044597)2.86480482
62aromatic amino acid family catabolic process (GO:0009074)2.86202612
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85331536
64negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85331536
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.85331536
66negative regulation of sister chromatid segregation (GO:0033046)2.85331536
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85331536
68GPI anchor metabolic process (GO:0006505)2.84672910
69L-phenylalanine metabolic process (GO:0006558)2.83599806
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83599806
71tryptophan catabolic process (GO:0006569)2.82290286
72indole-containing compound catabolic process (GO:0042436)2.82290286
73indolalkylamine catabolic process (GO:0046218)2.82290286
74tryptophan metabolic process (GO:0006568)2.82280274
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82256077
76protein localization to cilium (GO:0061512)2.81493757
77organelle disassembly (GO:1903008)2.79746276
78microtubule polymerization or depolymerization (GO:0031109)2.79357045
79cellular response to interferon-beta (GO:0035458)2.79090140
80protoporphyrinogen IX metabolic process (GO:0046501)2.77766862
81mitotic spindle checkpoint (GO:0071174)2.77172839
82DNA replication checkpoint (GO:0000076)2.76993051
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75856289
84spindle checkpoint (GO:0031577)2.75357285
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73184134
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73184134
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71657495
88negative regulation of chromosome segregation (GO:0051985)2.69843877
89rRNA methylation (GO:0031167)2.69354153
90kinetochore organization (GO:0051383)2.68979774
91DNA methylation involved in gamete generation (GO:0043046)2.68856798
92GPI anchor biosynthetic process (GO:0006506)2.68355487
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68343446
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.68343446
95aldehyde catabolic process (GO:0046185)2.68300349
96mitotic spindle assembly checkpoint (GO:0007094)2.68112110
97DNA replication-dependent nucleosome assembly (GO:0006335)2.67369879
98DNA replication-dependent nucleosome organization (GO:0034723)2.67369879
99protoporphyrinogen IX biosynthetic process (GO:0006782)2.67249703
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67135255
101signal peptide processing (GO:0006465)2.66586121
102cholesterol biosynthetic process (GO:0006695)2.66492620
103anterograde synaptic vesicle transport (GO:0048490)2.66203904
104sterol biosynthetic process (GO:0016126)2.65981873
105regulation of cilium movement (GO:0003352)2.65640599
106myeloid dendritic cell activation (GO:0001773)2.65575994
107cilium morphogenesis (GO:0060271)2.65361137
108spindle assembly checkpoint (GO:0071173)2.65068078
109negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.64998376
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63718799
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62547930
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62547930
113regulation of helicase activity (GO:0051095)2.61220223
114establishment of skin barrier (GO:0061436)2.61174553
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61009363
116negative regulation of meiosis (GO:0045835)2.60755545
117meiotic cell cycle process (GO:1903046)2.60719460
118regulation of natural killer cell differentiation (GO:0032823)2.59970554
119rRNA modification (GO:0000154)2.59586353
120T-helper cell differentiation (GO:0042093)2.58383149
121CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58383149
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.58042222
123regulation of sister chromatid segregation (GO:0033045)2.56197715
124regulation of mitotic sister chromatid separation (GO:0010965)2.56197715
125regulation of mitotic sister chromatid segregation (GO:0033047)2.56197715
126establishment of integrated proviral latency (GO:0075713)2.55958486
127regulation of T cell mediated cytotoxicity (GO:0001914)2.55570267
128positive regulation of B cell differentiation (GO:0045579)2.55525875
129antigen processing and presentation of endogenous antigen (GO:0019883)2.54344084
130response to pheromone (GO:0019236)2.53423214
131branched-chain amino acid catabolic process (GO:0009083)2.53178576
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52889872
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52889872
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52329196
135somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52329196
136isotype switching (GO:0045190)2.52329196
137meiotic nuclear division (GO:0007126)2.52287242
138bile acid biosynthetic process (GO:0006699)2.52115496
139type I interferon signaling pathway (GO:0060337)2.51876595
140cellular response to type I interferon (GO:0071357)2.51876595
141C-terminal protein amino acid modification (GO:0018410)2.51345425
142IMP biosynthetic process (GO:0006188)2.51150221
143response to type I interferon (GO:0034340)2.50864719
144regulation of cholesterol esterification (GO:0010872)2.50650051
145neutrophil activation (GO:0042119)2.50304743
146replication fork processing (GO:0031297)2.49554091
147C-terminal protein lipidation (GO:0006501)2.48647940
148cellular response to growth hormone stimulus (GO:0071378)2.46567593
149triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46511066
150hepatocyte apoptotic process (GO:0097284)2.45616051
151viral transcription (GO:0019083)2.44219928
152myeloid dendritic cell differentiation (GO:0043011)2.41566990
153positive regulation of antigen processing and presentation (GO:0002579)2.41384882
154NIK/NF-kappaB signaling (GO:0038061)2.41168541
155positive regulation of humoral immune response (GO:0002922)2.39981674
156respiratory chain complex IV assembly (GO:0008535)2.39141243
157peroxisome fission (GO:0016559)2.35970105
158NAD biosynthetic process (GO:0009435)2.35709602
159immunoglobulin mediated immune response (GO:0016064)2.34860874
160cellular response to zinc ion (GO:0071294)2.34646285
161positive regulation of respiratory burst (GO:0060267)2.30368462
162S-adenosylmethionine metabolic process (GO:0046500)2.28700703
163SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.28530826
164detection of external biotic stimulus (GO:0098581)2.27768317
165translational termination (GO:0006415)2.27171958
166negative regulation of viral genome replication (GO:0045071)2.25654387
167cotranslational protein targeting to membrane (GO:0006613)2.25521986
168myoblast migration (GO:0051451)2.24698645
169granulocyte activation (GO:0036230)2.24501881
170lymph node development (GO:0048535)2.24395012
171positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.23426046
172regulation of hypersensitivity (GO:0002883)2.22460485
173fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.21622969
174protein targeting to ER (GO:0045047)2.20552854
175positive regulation of gamma-delta T cell activation (GO:0046645)2.20509212
176regulation of triglyceride catabolic process (GO:0010896)2.20243680
177definitive hemopoiesis (GO:0060216)2.20096494
178phenylpropanoid metabolic process (GO:0009698)2.19937070
179lymphoid progenitor cell differentiation (GO:0002320)2.19177170
180negative regulation of nitric oxide biosynthetic process (GO:0045019)2.18645386
181aerobic respiration (GO:0009060)2.17633457
182glyoxylate metabolic process (GO:0046487)2.17287917
183indolalkylamine metabolic process (GO:0006586)2.16988847
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.16717926
185protein localization to endoplasmic reticulum (GO:0070972)2.16534798
186imidazole-containing compound metabolic process (GO:0052803)2.15446484
187pyridine nucleotide biosynthetic process (GO:0019363)2.14337246
188nicotinamide nucleotide biosynthetic process (GO:0019359)2.14337246
189CD4-positive, alpha-beta T cell activation (GO:0035710)2.14008803
190CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.12944339
191antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.12797127
192endosome to melanosome transport (GO:0035646)2.12567026
193endosome to pigment granule transport (GO:0043485)2.12567026
194regulation of necroptotic process (GO:0060544)2.12521661
195regulation of B cell differentiation (GO:0045577)2.12373997
196ribosomal small subunit biogenesis (GO:0042274)2.11510522
197high-density lipoprotein particle remodeling (GO:0034375)2.11495022
198cellular biogenic amine catabolic process (GO:0042402)2.11489254
199amine catabolic process (GO:0009310)2.11489254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.45445289
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.91679164
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75614667
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.59016683
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57599239
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.30975848
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97837186
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90797588
9ZNF274_21170338_ChIP-Seq_K562_Hela2.88330362
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83050147
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.80447129
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.59179558
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.55090519
14FUS_26573619_Chip-Seq_HEK293_Human2.52614068
15EWS_26573619_Chip-Seq_HEK293_Human2.50476487
16GATA1_22025678_ChIP-Seq_K562_Human2.49476911
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47646378
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.34374640
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30127895
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25186284
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18189206
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.17290920
23P300_19829295_ChIP-Seq_ESCs_Human2.15580674
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10730281
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08633442
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08315779
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08215859
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.04518136
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04172373
30* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03586859
31GBX2_23144817_ChIP-Seq_PC3_Human2.01285718
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95738761
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94100592
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.90691716
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85525526
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84395674
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82722863
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.78743413
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.78457538
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77700261
41* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75647404
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74353667
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72857440
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69702367
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.68842582
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65656521
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64968295
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64727851
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64711393
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63825489
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.62601520
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61120745
53ELK1_19687146_ChIP-ChIP_HELA_Human1.59851704
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58916965
55SPI1_23547873_ChIP-Seq_NB4_Human1.57757336
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55673507
57SCL_19346495_ChIP-Seq_HPC-7_Human1.55398203
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54233163
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53583379
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53010908
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51135655
62VDR_23849224_ChIP-Seq_CD4+_Human1.48177147
63ER_23166858_ChIP-Seq_MCF-7_Human1.47364179
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47187110
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42984040
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42094134
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39861410
68CBP_20019798_ChIP-Seq_JUKART_Human1.38767629
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38767629
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37870007
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37620223
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36521242
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35850532
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34260342
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34125476
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32661015
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30596031
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30186353
79VDR_22108803_ChIP-Seq_LS180_Human1.29974600
80* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29818454
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29468249
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28834663
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27940906
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27519283
85SOX2_19829295_ChIP-Seq_ESCs_Human1.26774147
86NANOG_19829295_ChIP-Seq_ESCs_Human1.26774147
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25714381
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25071215
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.24502860
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23723831
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.23608031
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.23461847
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23277126
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23201249
95SMAD4_21799915_ChIP-Seq_A2780_Human1.22573994
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22447538
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.21283462
98AR_25329375_ChIP-Seq_VCAP_Human1.21173314
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20491297
100* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19096265
101MYB_26560356_Chip-Seq_TH2_Human1.19003944
102* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18411648
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18209088
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17818401
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17427028
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17063827
107TAF15_26573619_Chip-Seq_HEK293_Human1.16377832
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16231047
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.16024144
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15655005
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14748116
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14540933
113DCP1A_22483619_ChIP-Seq_HELA_Human1.14030898
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.13792281
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13614619
116IRF1_19129219_ChIP-ChIP_H3396_Human1.13463084
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13413461
118BCAT_22108803_ChIP-Seq_LS180_Human1.13068643
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.12077080
120RNF2_27304074_Chip-Seq_NSC_Mouse1.11610184
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.11559505
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11445726
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11391219
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10503626
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.10421325
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09831150
127* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08659458
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07568446
129TCF4_22108803_ChIP-Seq_LS180_Human1.06065145
130* RUNX2_22187159_ChIP-Seq_PCA_Human1.06024907
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05256755
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04432530
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04201229
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04201179
135P53_22387025_ChIP-Seq_ESCs_Mouse1.03282918
136RUNX_20019798_ChIP-Seq_JUKART_Human1.03168041
137* GATA3_26560356_Chip-Seq_TH2_Human1.01642458
138HTT_18923047_ChIP-ChIP_STHdh_Human1.00586213
139RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00484450
140P300_18555785_Chip-Seq_ESCs_Mouse1.00281487
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00242744
142MYC_18940864_ChIP-ChIP_HL60_Human0.99623189
143E2F1_18555785_Chip-Seq_ESCs_Mouse0.98813581
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.98757922
145TP53_22573176_ChIP-Seq_HFKS_Human0.98658609
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97910732
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97567759
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97465127
149STAT3_23295773_ChIP-Seq_U87_Human0.97032976
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96172628
151* CDX2_22108803_ChIP-Seq_LS180_Human0.95258615
152MYB_26560356_Chip-Seq_TH1_Human0.95028593
153FOXP3_21729870_ChIP-Seq_TREG_Human0.94368115
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93538197
155* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93195933
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91395703
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89516698
158HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89207862
159PU_27001747_Chip-Seq_BMDM_Mouse0.89079631
160IGF1R_20145208_ChIP-Seq_DFB_Human0.87628668
161SALL4_22934838_ChIP-ChIP_CD34+_Human0.86765613
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86601637
163* AR_20517297_ChIP-Seq_VCAP_Human0.86544887
164GATA3_27048872_Chip-Seq_THYMUS_Human0.85709324
165STAT1_17558387_ChIP-Seq_HELA_Human0.85508950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.43847158
2MP0008877_abnormal_DNA_methylation4.05542370
3MP0002139_abnormal_hepatobiliary_system3.44208035
4MP0001835_abnormal_antigen_presentation3.34943819
5MP0008058_abnormal_DNA_repair3.26270780
6MP0009379_abnormal_foot_pigmentation3.15713343
7MP0000685_abnormal_immune_system2.99449750
8MP0002254_reproductive_system_inflammat2.93612237
9MP0001529_abnormal_vocalization2.88699204
10MP0009785_altered_susceptibility_to2.82328942
11MP0005671_abnormal_response_to2.52258711
12MP0005360_urolithiasis2.51324940
13MP0003724_increased_susceptibility_to2.48915775
14MP0005365_abnormal_bile_salt2.46040661
15MP0003880_abnormal_central_pattern2.43358190
16MP0005085_abnormal_gallbladder_physiolo2.41221519
17MP0002148_abnormal_hypersensitivity_rea2.36069966
18MP0003718_maternal_effect2.34499304
19MP0006054_spinal_hemorrhage2.31521841
20MP0006072_abnormal_retinal_apoptosis2.23239589
21MP0008789_abnormal_olfactory_epithelium2.20029532
22MP0001188_hyperpigmentation2.14860303
23MP0003890_abnormal_embryonic-extraembry2.13800963
24MP0003191_abnormal_cellular_cholesterol2.11971360
25MP0008875_abnormal_xenobiotic_pharmacok2.07685162
26MP0000372_irregular_coat_pigmentation2.00252078
27MP0010094_abnormal_chromosome_stability1.96313415
28MP0003121_genomic_imprinting1.91922037
29MP0003787_abnormal_imprinting1.91144527
30MP0001984_abnormal_olfaction1.89409272
31MP0004957_abnormal_blastocyst_morpholog1.89384950
32MP0008057_abnormal_DNA_replication1.88441394
33MP0003567_abnormal_fetal_cardiomyocyte1.86645857
34MP0001800_abnormal_humoral_immune1.85832407
35MP0005253_abnormal_eye_physiology1.85703422
36MP0002166_altered_tumor_susceptibility1.84734120
37MP0005025_abnormal_response_to1.84533188
38MP0003693_abnormal_embryo_hatching1.82730497
39MP0001790_abnormal_immune_system1.82331276
40MP0005387_immune_system_phenotype1.82331276
41MP0002163_abnormal_gland_morphology1.80934022
42MP0002009_preneoplasia1.80462675
43MP0005451_abnormal_body_composition1.80172099
44MP0005394_taste/olfaction_phenotype1.78496394
45MP0005499_abnormal_olfactory_system1.78496394
46MP0002876_abnormal_thyroid_physiology1.77344374
47MP0009697_abnormal_copulation1.76068368
48MP0002736_abnormal_nociception_after1.74904669
49MP0005379_endocrine/exocrine_gland_phen1.74313419
50MP0003656_abnormal_erythrocyte_physiolo1.70904957
51MP0001293_anophthalmia1.70795878
52MP0004215_abnormal_myocardial_fiber1.70519836
53MP0004133_heterotaxia1.69418565
54MP0003436_decreased_susceptibility_to1.68379884
55MP0002723_abnormal_immune_serum1.67661484
56MP0002452_abnormal_antigen_presenting1.66740920
57MP0005000_abnormal_immune_tolerance1.66068114
58MP0003186_abnormal_redox_activity1.64084087
59MP0004782_abnormal_surfactant_physiolog1.63401583
60MP0001929_abnormal_gametogenesis1.62715825
61MP0008932_abnormal_embryonic_tissue1.62310146
62MP0009764_decreased_sensitivity_to1.58441834
63MP0002210_abnormal_sex_determination1.56995939
64MP0004147_increased_porphyrin_level1.56743630
65MP0002419_abnormal_innate_immunity1.55730641
66MP0003122_maternal_imprinting1.54266976
67MP0001853_heart_inflammation1.53218486
68MP0002006_tumorigenesis1.51731622
69MP0001819_abnormal_immune_cell1.50790859
70MP0002420_abnormal_adaptive_immunity1.50279437
71MP0001764_abnormal_homeostasis1.45390478
72MP0008469_abnormal_protein_level1.41675499
73MP0006276_abnormal_autonomic_nervous1.41126599
74MP0006082_CNS_inflammation1.41040246
75MP0003119_abnormal_digestive_system1.40088646
76MP0002090_abnormal_vision1.39770341
77MP0003763_abnormal_thymus_physiology1.39566454
78MP0000653_abnormal_sex_gland1.39396005
79MP0002132_abnormal_respiratory_system1.38794345
80MP0006035_abnormal_mitochondrial_morpho1.38329121
81MP0004947_skin_inflammation1.38006577
82MP0002233_abnormal_nose_morphology1.37339563
83MP0002277_abnormal_respiratory_mucosa1.36245143
84MP0000647_abnormal_sebaceous_gland1.35374815
85MP0003941_abnormal_skin_development1.35270745
86MP0003221_abnormal_cardiomyocyte_apopto1.35045173
87MP0008995_early_reproductive_senescence1.34937207
88MP0005084_abnormal_gallbladder_morpholo1.34676657
89MP0003698_abnormal_male_reproductive1.33921820
90MP0001145_abnormal_male_reproductive1.33844971
91MP0010329_abnormal_lipoprotein_level1.33100330
92MP0005248_abnormal_Harderian_gland1.32915754
93MP0002751_abnormal_autonomic_nervous1.30867481
94MP0002796_impaired_skin_barrier1.29916856
95MP0003252_abnormal_bile_duct1.27840729
96MP0003077_abnormal_cell_cycle1.27064604
97MP0001873_stomach_inflammation1.26484463
98MP0001845_abnormal_inflammatory_respons1.25949392
99MP0005464_abnormal_platelet_physiology1.25254352
100MP0005367_renal/urinary_system_phenotyp1.23930244
101MP0000516_abnormal_urinary_system1.23930244
102MP0005551_abnormal_eye_electrophysiolog1.23403035
103MP0000049_abnormal_middle_ear1.19519736
104MP0003786_premature_aging1.19421120
105MP0003195_calcinosis1.18010354
106MP0002398_abnormal_bone_marrow1.17884787
107MP0000609_abnormal_liver_physiology1.17586033
108MP0001485_abnormal_pinna_reflex1.16768144
109MP0000716_abnormal_immune_system1.16102352
110MP0010155_abnormal_intestine_physiology1.14947682
111MP0005310_abnormal_salivary_gland1.12761843
112MP0002405_respiratory_system_inflammati1.09439923
113MP0001346_abnormal_lacrimal_gland1.09244240
114MP0000689_abnormal_spleen_morphology1.09093140
115MP0001986_abnormal_taste_sensitivity1.08485488
116MP0003937_abnormal_limbs/digits/tail_de1.08218106
117MP0003136_yellow_coat_color1.08052367
118MP0001177_atelectasis1.06655926
119MP0006292_abnormal_olfactory_placode1.05373627
120MP0000631_abnormal_neuroendocrine_gland1.04784885
121MP0003111_abnormal_nucleus_morphology1.03475885
122MP0004510_myositis1.01715107
123MP0003137_abnormal_impulse_conducting1.01508455
124MP0002429_abnormal_blood_cell1.00698819
125MP0001666_abnormal_nutrient_absorption1.00645758
126MP0005332_abnormal_amino_acid1.00561429
127MP0005636_abnormal_mineral_homeostasis1.00397119
128MP0003011_delayed_dark_adaptation1.00116109
129MP0003806_abnormal_nucleotide_metabolis0.99320011
130MP0009333_abnormal_splenocyte_physiolog0.99315927
131MP0001119_abnormal_female_reproductive0.98084015
132MP0002234_abnormal_pharynx_morphology0.98013924
133MP0005083_abnormal_biliary_tract0.97626995
134MP0005410_abnormal_fertilization0.97336757
135MP0006036_abnormal_mitochondrial_physio0.97300721
136MP0001486_abnormal_startle_reflex0.97087435
137MP0002722_abnormal_immune_system0.97053611
138MP0005391_vision/eye_phenotype0.95758264
139MP0002095_abnormal_skin_pigmentation0.94355783
140MP0004381_abnormal_hair_follicle0.94230452
141MP0002938_white_spotting0.93417281
142MP0004019_abnormal_vitamin_homeostasis0.92647668
143MP0001324_abnormal_eye_pigmentation0.92641919
144MP0009763_increased_sensitivity_to0.90978570
145MP0002102_abnormal_ear_morphology0.90185858
146MP0005408_hypopigmentation0.90075513
147MP0001286_abnormal_eye_development0.88190268
148MP0005501_abnormal_skin_physiology0.86893443
149MP0008007_abnormal_cellular_replicative0.86007181
150MP0002160_abnormal_reproductive_system0.85693276
151MP0005319_abnormal_enzyme/_coenzyme0.84965668
152MP0000358_abnormal_cell_content/0.83182672
153MP0000778_abnormal_nervous_system0.81549980
154MP0002638_abnormal_pupillary_reflex0.81489866
155MP0004142_abnormal_muscle_tone0.80540746
156MP0001968_abnormal_touch/_nociception0.80205735
157MP0005389_reproductive_system_phenotype0.79950011
158MP0001879_abnormal_lymphatic_vessel0.79828693
159MP0000427_abnormal_hair_cycle0.78329606
160MP0005647_abnormal_sex_gland0.78222389
161MP0002118_abnormal_lipid_homeostasis0.77492911
162MP0005220_abnormal_exocrine_pancreas0.77303721
163MP0000490_abnormal_crypts_of0.75414544
164MP0000681_abnormal_thyroid_gland0.74882992
165MP0003943_abnormal_hepatobiliary_system0.74850566
166MP0004197_abnormal_fetal_growth/weight/0.74774465
167MP0009765_abnormal_xenobiotic_induced0.73841202
168MP0005187_abnormal_penis_morphology0.73626082
169MP0000598_abnormal_liver_morphology0.73254123
170MP0005584_abnormal_enzyme/coenzyme_acti0.72677257
171MP0005397_hematopoietic_system_phenotyp0.72425845
172MP0001545_abnormal_hematopoietic_system0.72425845
173MP0001348_abnormal_lacrimal_gland0.72211939
174MP0005395_other_phenotype0.72186575
175MP0005075_abnormal_melanosome_morpholog0.71509413
176MP0004924_abnormal_behavior0.71309574
177MP0005386_behavior/neurological_phenoty0.71309574
178MP0010368_abnormal_lymphatic_system0.71099801
179MP0009643_abnormal_urine_homeostasis0.71049989
180MP0002084_abnormal_developmental_patter0.70766165
181MP0001727_abnormal_embryo_implantation0.70525227
182MP0009046_muscle_twitch0.69510840
183MP0002837_dystrophic_cardiac_calcinosis0.68702768
184MP0003646_muscle_fatigue0.68121188
185MP0002161_abnormal_fertility/fecundity0.67354509
186MP0001697_abnormal_embryo_size0.65687340

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.83964777
2Prolonged partial thromboplastin time (HP:0003645)3.65582353
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.64507615
4Hyperglycinemia (HP:0002154)3.45302009
5Abnormality of the labia minora (HP:0012880)3.16347829
6Medial flaring of the eyebrow (HP:0010747)3.09149939
7Abnormality of the anterior horn cell (HP:0006802)3.08138235
8Degeneration of anterior horn cells (HP:0002398)3.08138235
9True hermaphroditism (HP:0010459)2.99829606
10Recurrent gram-negative bacterial infections (HP:0005420)2.98429142
11Abnormality of the heme biosynthetic pathway (HP:0010472)2.93248838
12Colon cancer (HP:0003003)2.89605065
13Hypothermia (HP:0002045)2.86488581
14Exertional dyspnea (HP:0002875)2.86175471
15Recurrent bacterial skin infections (HP:0005406)2.85145626
16Volvulus (HP:0002580)2.84568464
17Renal Fanconi syndrome (HP:0001994)2.84484393
18Gonadotropin excess (HP:0000837)2.84368090
19Increased hepatocellular lipid droplets (HP:0006565)2.83244159
20Congenital primary aphakia (HP:0007707)2.82419484
21Lipid accumulation in hepatocytes (HP:0006561)2.81991527
22Gait imbalance (HP:0002141)2.73312735
23Hypobetalipoproteinemia (HP:0003563)2.73157701
24Myositis (HP:0100614)2.69745360
25Recurrent abscess formation (HP:0002722)2.68366243
26Methylmalonic acidemia (HP:0002912)2.63758897
27Nephrogenic diabetes insipidus (HP:0009806)2.60841882
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60781909
29Abnormality of serum amino acid levels (HP:0003112)2.58120672
30Pancreatic fibrosis (HP:0100732)2.57579245
31Pancreatic cysts (HP:0001737)2.54596611
32Acute necrotizing encephalopathy (HP:0006965)2.53860154
33Reduced antithrombin III activity (HP:0001976)2.52920043
34Increased intramyocellular lipid droplets (HP:0012240)2.50150681
35Increased muscle lipid content (HP:0009058)2.49030689
36Intrahepatic cholestasis (HP:0001406)2.48674899
37Mitochondrial inheritance (HP:0001427)2.48453192
38Optic neuritis (HP:0100653)2.47662519
39Retrobulbar optic neuritis (HP:0100654)2.47662519
40Elevated erythrocyte sedimentation rate (HP:0003565)2.47249885
41Genital tract atresia (HP:0001827)2.46324069
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.45196240
43Intestinal atresia (HP:0011100)2.44488045
443-Methylglutaconic aciduria (HP:0003535)2.43373713
45Abnormal mitochondria in muscle tissue (HP:0008316)2.42229385
46Acute encephalopathy (HP:0006846)2.40507909
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39943946
48Abnormality of serine family amino acid metabolism (HP:0010894)2.39281755
49Abnormality of glycine metabolism (HP:0010895)2.39281755
50Vacuolated lymphocytes (HP:0001922)2.38953017
51Cerebral edema (HP:0002181)2.37771652
52Orchitis (HP:0100796)2.36548440
53Molar tooth sign on MRI (HP:0002419)2.35860874
54Abnormality of midbrain morphology (HP:0002418)2.35860874
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35676305
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35676305
57Hyperglycinuria (HP:0003108)2.35572215
58Vaginal atresia (HP:0000148)2.35231702
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34483076
60Amyotrophic lateral sclerosis (HP:0007354)2.34079151
61Joint hemorrhage (HP:0005261)2.33369605
62Abnormal lung lobation (HP:0002101)2.31492323
63Abnormality of fatty-acid metabolism (HP:0004359)2.30307741
64Abnormality of urine glucose concentration (HP:0011016)2.30249565
65Glycosuria (HP:0003076)2.30249565
66Hyperbilirubinemia (HP:0002904)2.30132791
67Hepatic necrosis (HP:0002605)2.29261452
68Generalized aminoaciduria (HP:0002909)2.28523461
69Shoulder girdle muscle weakness (HP:0003547)2.28315065
70Nephronophthisis (HP:0000090)2.27978400
71Abnormality of methionine metabolism (HP:0010901)2.24251410
72Recurrent skin infections (HP:0001581)2.23612385
73Median cleft lip (HP:0000161)2.20808634
74Abnormal number of erythroid precursors (HP:0012131)2.20221375
75Thrombocytosis (HP:0001894)2.19343073
76Supernumerary spleens (HP:0009799)2.18409164
77Abnormality of cells of the erythroid lineage (HP:0012130)2.17269508
78Aplastic anemia (HP:0001915)2.15720925
79Gangrene (HP:0100758)2.14132923
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13431678
81Mediastinal lymphadenopathy (HP:0100721)2.13427189
82Progressive macrocephaly (HP:0004481)2.13141395
83Renal cortical cysts (HP:0000803)2.12598199
84Increased CSF lactate (HP:0002490)2.12550850
85Poikilocytosis (HP:0004447)2.12363431
86Abnormality of macrophages (HP:0004311)2.11168239
87Abnormality of chromosome stability (HP:0003220)2.11019666
88Septo-optic dysplasia (HP:0100842)2.08235856
89Microcytic anemia (HP:0001935)2.08074689
90Spontaneous abortion (HP:0005268)2.07546379
91Conjugated hyperbilirubinemia (HP:0002908)2.07083197
92Encephalitis (HP:0002383)2.07045191
93Hepatocellular necrosis (HP:0001404)2.06930218
94Short tibia (HP:0005736)2.03748300
95Respiratory difficulties (HP:0002880)2.03029210
96Recurrent fungal infections (HP:0002841)2.02980294
97Abolished electroretinogram (ERG) (HP:0000550)2.02710109
98Increased IgM level (HP:0003496)2.02181899
99Agammaglobulinemia (HP:0004432)2.01890550
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01739265
101Abnormality of alanine metabolism (HP:0010916)2.01739265
102Hyperalaninemia (HP:0003348)2.01739265
103Fat malabsorption (HP:0002630)1.99957028
104Type 2 muscle fiber atrophy (HP:0003554)1.99747293
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.99134077
106Keratoconjunctivitis (HP:0001096)1.98793792
107Congenital, generalized hypertrichosis (HP:0004540)1.98538233
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98527533
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.98527533
110Papillary thyroid carcinoma (HP:0002895)1.96889208
111Congenital ichthyosiform erythroderma (HP:0007431)1.96538948
112Meckel diverticulum (HP:0002245)1.96386383
113Petechiae (HP:0000967)1.96276959
114Pruritus (HP:0000989)1.96072913
115Cerebral palsy (HP:0100021)1.95950821
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.95853481
117Abnormality of the axillary hair (HP:0100134)1.95462947
118Abnormality of secondary sexual hair (HP:0009888)1.95462947
119Tubulointerstitial nephritis (HP:0001970)1.95273739
120Keratoconjunctivitis sicca (HP:0001097)1.93945154
121Lactic acidosis (HP:0003128)1.93925066
122Broad foot (HP:0001769)1.93858309
123Hypochromic anemia (HP:0001931)1.93594820
124Optic nerve hypoplasia (HP:0000609)1.92829068
125IgM deficiency (HP:0002850)1.92824046
126Steatorrhea (HP:0002570)1.92588657
127Abnormality of the renal medulla (HP:0100957)1.92523650
128Abnormality of the hip-girdle musculature (HP:0001445)1.92088413
129Abnormality of the musculature of the pelvis (HP:0001469)1.92088413
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.91638976
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91623560
132Abnormality of the ileum (HP:0001549)1.91518800
133Urticaria (HP:0001025)1.91510779
134Abnormal respiratory motile cilium morphology (HP:0005938)1.91482381
135Abnormal respiratory epithelium morphology (HP:0012253)1.91482381
136Lethargy (HP:0001254)1.90789286
137Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90701093
138Abnormality of renal resorption (HP:0011038)1.90333756
139Purpura (HP:0000979)1.89754732
140Small intestinal stenosis (HP:0012848)1.89181444
141Duodenal stenosis (HP:0100867)1.89181444
142Chronic mucocutaneous candidiasis (HP:0002728)1.88398697
143Recurrent cutaneous fungal infections (HP:0011370)1.88398697
144Meningitis (HP:0001287)1.88395611
145IgG deficiency (HP:0004315)1.88221094
146Alveolar cell carcinoma (HP:0006519)1.88081773
147Methylmalonic aciduria (HP:0012120)1.87862425
148Poor coordination (HP:0002370)1.87422299
149Male pseudohermaphroditism (HP:0000037)1.87316230
150Brushfield spots (HP:0001088)1.87155935
151Acanthocytosis (HP:0001927)1.86658199
152Progressive inability to walk (HP:0002505)1.85882216
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85288448
154Increased IgE level (HP:0003212)1.84281510
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.84115168
156Nephroblastoma (Wilms tumor) (HP:0002667)1.83503881
157Complement deficiency (HP:0004431)1.82897109
158Abnormality of the duodenum (HP:0002246)1.82789781
159Metabolic acidosis (HP:0001942)1.82460479
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82209709
161Thyroid-stimulating hormone excess (HP:0002925)1.82060847
162Exercise-induced muscle cramps (HP:0003710)1.82001525
163Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81690109
164Poor suck (HP:0002033)1.81674009
165Hyperammonemia (HP:0001987)1.81413406
166Joint swelling (HP:0001386)1.81191378
167Ketosis (HP:0001946)1.81010125
168Biliary tract neoplasm (HP:0100574)1.80419234
169Embryonal renal neoplasm (HP:0011794)1.80291554
170Abnormal respiratory motile cilium physiology (HP:0012261)1.79593639
171Dyschromatopsia (HP:0007641)1.77491071
172Abnormal biliary tract physiology (HP:0012439)1.77308357
173Bile duct proliferation (HP:0001408)1.77308357
174Postaxial hand polydactyly (HP:0001162)1.77169889
175Abnormal hair whorl (HP:0010721)1.74736357
176Increased serum pyruvate (HP:0003542)1.74563856
177Rimmed vacuoles (HP:0003805)1.74501325
178Decreased testicular size (HP:0008734)1.74495783
179Cortical dysplasia (HP:0002539)1.73272245
180Stenosis of the external auditory canal (HP:0000402)1.71387195
181Postaxial foot polydactyly (HP:0001830)1.71325345
182Oculomotor apraxia (HP:0000657)1.71306352
183Dynein arm defect of respiratory motile cilia (HP:0012255)1.71287806
184Absent/shortened dynein arms (HP:0200106)1.71287806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.03874322
2WNK33.27041196
3MAP3K143.14691592
4IRAK42.67381305
5STK162.47567828
6KIT2.44869317
7IKBKE2.44726501
8MAP3K122.35385468
9TBK12.26360753
10DYRK32.04434471
11MAP3K42.03451345
12FLT32.00388768
13TYK21.99845279
14TXK1.97937263
15MAP4K21.92382672
16IKBKB1.88797408
17PIK3CG1.86146275
18PLK21.85354218
19BMPR21.84260970
20EIF2AK11.84098999
21JAK31.83177264
22EPHA31.82569706
23NEK91.78572881
24BMPR1B1.78567017
25TEC1.78402480
26MST41.77254246
27WEE11.71747175
28TAOK31.70317085
29ZAK1.63381947
30PLK31.62209732
31NLK1.62142179
32IRAK11.54833901
33NEK11.53949042
34BCKDK1.53737951
35NME21.52626536
36TNIK1.51682938
37CHUK1.51125169
38STK38L1.50974472
39IRAK31.50651824
40MUSK1.50510652
41PNCK1.48443280
42FGFR41.45627932
43CDK81.40573393
44RIPK41.38798706
45IRAK21.38644085
46CSNK1G21.37153434
47TTK1.36135761
48BRSK21.33989421
49CASK1.33652669
50MAPK131.33285369
51MAP3K131.31706479
52CSNK1G31.26285881
53MAP4K11.25923356
54CSNK1G11.25385358
55EIF2AK31.22540097
56PBK1.18918541
57PIM21.16974316
58PINK11.15928165
59SIK31.14928539
60VRK11.13745657
61INSRR1.11847448
62TGFBR21.11410807
63RPS6KA41.10460968
64YES11.10097949
65BTK1.08362436
66MAPKAPK31.07561909
67PLK11.06675956
68ACVR1B1.04897624
69MARK11.04115592
70MYLK1.02592877
71SYK1.02159621
72CCNB11.01156685
73SRPK11.01090323
74EIF2AK21.00873790
75DYRK1B0.96720658
76ADRBK20.96656402
77CSNK1A1L0.95986849
78TSSK60.94221956
79ERBB30.91235960
80EPHA40.90227965
81BLK0.87017174
82MAPK110.83544614
83CDC70.83011035
84JAK10.80921059
85LYN0.80832105
86OXSR10.80432952
87MINK10.79488345
88TGFBR10.79366034
89FGFR30.78954269
90BUB10.78769476
91DYRK20.78203709
92PIM10.77829380
93PRKCE0.77050809
94BCR0.74780992
95PRKAA20.73499203
96ERBB40.73427664
97CDK60.71018788
98PLK40.66316685
99CSF1R0.64405745
100MKNK10.64249125
101STK30.64214085
102ZAP700.63534786
103MAPK150.62943956
104KDR0.62539298
105LCK0.62514859
106BRAF0.62364915
107NUAK10.62258407
108TAF10.59873056
109MAP2K70.59758884
110PDK20.59646545
111JAK20.59602957
112TIE10.59577487
113TLK10.57814414
114MAP2K30.57469551
115RPS6KA50.57364666
116FRK0.56190712
117PRKCG0.56042466
118CDK90.55134407
119LIMK10.55132605
120OBSCN0.54536223
121GRK10.54383450
122STK390.54318762
123MATK0.51031117
124KSR10.50463701
125PAK30.50336243
126EGFR0.48763302
127MAP3K50.48448704
128ITK0.48129236
129CDK30.47394368
130MKNK20.47391183
131CSNK2A10.44476613
132DYRK1A0.44443413
133ATM0.43298070
134HIPK20.43168498
135MAPK40.43067440
136CDK190.42571437
137FER0.42279491
138ATR0.41945136
139CAMK2A0.41034020
140UHMK10.39017358
141STK240.37713377
142GRK60.37629513
143ABL20.36245187
144GRK70.35945761
145STK40.35931014
146BRSK10.32753180
147CDK140.32200197
148AURKB0.28862227
149PRKG10.28841724
150PKN10.26609917
151FGR0.26423972
152PRKACB0.26175230
153FGFR10.25844671
154CSNK2A20.25716900
155CDK180.25501690

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.75990981
2Steroid biosynthesis_Homo sapiens_hsa001002.66316141
3Mismatch repair_Homo sapiens_hsa034302.47337605
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46478913
5Non-homologous end-joining_Homo sapiens_hsa034502.40816699
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37649683
7Protein export_Homo sapiens_hsa030602.33420877
8Ribosome_Homo sapiens_hsa030102.32113260
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15852172
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.11578898
11Caffeine metabolism_Homo sapiens_hsa002322.11296144
12Fanconi anemia pathway_Homo sapiens_hsa034602.02965751
13Proteasome_Homo sapiens_hsa030501.94437564
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.88201842
15Allograft rejection_Homo sapiens_hsa053301.86832482
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80495027
17Peroxisome_Homo sapiens_hsa041461.79909949
18Primary immunodeficiency_Homo sapiens_hsa053401.76964316
19RNA transport_Homo sapiens_hsa030131.76377694
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75923827
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71390087
22Tryptophan metabolism_Homo sapiens_hsa003801.69976742
23Fatty acid degradation_Homo sapiens_hsa000711.69305187
24Staphylococcus aureus infection_Homo sapiens_hsa051501.68772485
25Butanoate metabolism_Homo sapiens_hsa006501.63296562
26Folate biosynthesis_Homo sapiens_hsa007901.62406869
27Complement and coagulation cascades_Homo sapiens_hsa046101.61762535
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58538646
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.57301528
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55616129
31Histidine metabolism_Homo sapiens_hsa003401.52605912
32Propanoate metabolism_Homo sapiens_hsa006401.51425215
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.49515957
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47880362
35Oxidative phosphorylation_Homo sapiens_hsa001901.46194432
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46036628
37Chemical carcinogenesis_Homo sapiens_hsa052041.40592324
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.38707683
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36984462
40Measles_Homo sapiens_hsa051621.35100364
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35005841
42Leishmaniasis_Homo sapiens_hsa051401.34945011
43Graft-versus-host disease_Homo sapiens_hsa053321.34789223
44Parkinsons disease_Homo sapiens_hsa050121.34779619
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33019575
46Retinol metabolism_Homo sapiens_hsa008301.31622349
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30682149
48Phototransduction_Homo sapiens_hsa047441.30234546
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29859026
50Autoimmune thyroid disease_Homo sapiens_hsa053201.29406654
51Cell cycle_Homo sapiens_hsa041101.29326683
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28671528
53Spliceosome_Homo sapiens_hsa030401.26206579
54RNA polymerase_Homo sapiens_hsa030201.25523090
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21941270
56Oocyte meiosis_Homo sapiens_hsa041141.20594119
57Herpes simplex infection_Homo sapiens_hsa051681.18713770
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15493682
59Legionellosis_Homo sapiens_hsa051341.15260841
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14529227
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10476469
62Fatty acid elongation_Homo sapiens_hsa000621.08838895
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.06445282
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06240240
65Collecting duct acid secretion_Homo sapiens_hsa049661.05754126
66PPAR signaling pathway_Homo sapiens_hsa033201.04749070
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02981639
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02221125
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01450327
70Drug metabolism - other enzymes_Homo sapiens_hsa009831.00826315
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00394113
72Hematopoietic cell lineage_Homo sapiens_hsa046401.00390327
73Sulfur relay system_Homo sapiens_hsa041220.99798695
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.99420061
75Pyrimidine metabolism_Homo sapiens_hsa002400.98915304
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98628151
77Rheumatoid arthritis_Homo sapiens_hsa053230.96642712
78Sulfur metabolism_Homo sapiens_hsa009200.95848342
79Pertussis_Homo sapiens_hsa051330.94484554
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91854457
81beta-Alanine metabolism_Homo sapiens_hsa004100.91387735
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90313932
83Purine metabolism_Homo sapiens_hsa002300.88947045
84Nicotine addiction_Homo sapiens_hsa050330.87755329
85Pyruvate metabolism_Homo sapiens_hsa006200.86408663
86ABC transporters_Homo sapiens_hsa020100.86269047
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86231225
88Influenza A_Homo sapiens_hsa051640.86082338
89Phenylalanine metabolism_Homo sapiens_hsa003600.85377021
90Antigen processing and presentation_Homo sapiens_hsa046120.82456968
91mRNA surveillance pathway_Homo sapiens_hsa030150.81778706
92RNA degradation_Homo sapiens_hsa030180.81573796
93Selenocompound metabolism_Homo sapiens_hsa004500.79320879
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79076957
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78764881
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76572756
97Arachidonic acid metabolism_Homo sapiens_hsa005900.74986869
98Alzheimers disease_Homo sapiens_hsa050100.74514234
99Glutathione metabolism_Homo sapiens_hsa004800.73005007
100Asthma_Homo sapiens_hsa053100.70518079
101Tyrosine metabolism_Homo sapiens_hsa003500.68060713
102Carbon metabolism_Homo sapiens_hsa012000.67794864
103Malaria_Homo sapiens_hsa051440.65826038
104Circadian rhythm_Homo sapiens_hsa047100.65367264
105Fatty acid metabolism_Homo sapiens_hsa012120.63834263
106Huntingtons disease_Homo sapiens_hsa050160.63681652
107Linoleic acid metabolism_Homo sapiens_hsa005910.62752919
108Base excision repair_Homo sapiens_hsa034100.62228474
109Other glycan degradation_Homo sapiens_hsa005110.62066990
110Nitrogen metabolism_Homo sapiens_hsa009100.61972273
111Toxoplasmosis_Homo sapiens_hsa051450.61345015
112Basal transcription factors_Homo sapiens_hsa030220.60887556
113Osteoclast differentiation_Homo sapiens_hsa043800.60570854
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59239005
115TNF signaling pathway_Homo sapiens_hsa046680.58617709
116Nucleotide excision repair_Homo sapiens_hsa034200.57510663
117Homologous recombination_Homo sapiens_hsa034400.56145084
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55815894
119One carbon pool by folate_Homo sapiens_hsa006700.54204780
120p53 signaling pathway_Homo sapiens_hsa041150.53351739
121Apoptosis_Homo sapiens_hsa042100.53026444
122DNA replication_Homo sapiens_hsa030300.52468801
123Metabolic pathways_Homo sapiens_hsa011000.50835274
124B cell receptor signaling pathway_Homo sapiens_hsa046620.50050748
125Arginine biosynthesis_Homo sapiens_hsa002200.49987719
126Olfactory transduction_Homo sapiens_hsa047400.49934501
127Hepatitis C_Homo sapiens_hsa051600.48241152
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48205741
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47102289
130Cardiac muscle contraction_Homo sapiens_hsa042600.46831388
131Arginine and proline metabolism_Homo sapiens_hsa003300.46389219
132Taste transduction_Homo sapiens_hsa047420.46122131
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46055338
134Tuberculosis_Homo sapiens_hsa051520.45559231
135Regulation of autophagy_Homo sapiens_hsa041400.45322061
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45213564
137GABAergic synapse_Homo sapiens_hsa047270.40587409
138Vitamin B6 metabolism_Homo sapiens_hsa007500.39796067
139Biosynthesis of amino acids_Homo sapiens_hsa012300.39158776
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34629598
141TGF-beta signaling pathway_Homo sapiens_hsa043500.32614117
142N-Glycan biosynthesis_Homo sapiens_hsa005100.27883348
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26227809
144Fat digestion and absorption_Homo sapiens_hsa049750.26130883
145Hedgehog signaling pathway_Homo sapiens_hsa043400.23191178
146Ether lipid metabolism_Homo sapiens_hsa005650.21388480
147Serotonergic synapse_Homo sapiens_hsa047260.21266597

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