ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	8.74694709
2	DNA methylation involved in gamete generation (GO:0043046)	6.87350706
3	regulation of meiosis I (GO:0060631)	6.78064465
4	male meiosis I (GO:0007141)	5.98971910
5	male meiosis (GO:0007140)	5.95157974
6	DNA synthesis involved in DNA repair (GO:0000731)	5.39745687
7	chromosome organization involved in meiosis (GO:0070192)	5.35137844
8	meiosis I (GO:0007127)	4.80708739
9	regulation of mitotic spindle checkpoint (GO:1903504)	4.48451529
10	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.48451529
11	positive regulation of lipoprotein lipase activity (GO:0051006)	4.46774071
12	positive regulation of triglyceride lipase activity (GO:0061365)	4.46774071
13	meiotic nuclear division (GO:0007126)	4.39575247
14	gonadal mesoderm development (GO:0007506)	4.32074129
15	protein complex biogenesis (GO:0070271)	4.30504735
16	positive regulation of meiosis (GO:0045836)	4.29189414
17	establishment of integrated proviral latency (GO:0075713)	4.24887079
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.24754965
19	proteasome assembly (GO:0043248)	4.22102028
20	mitotic sister chromatid cohesion (GO:0007064)	4.18625368
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.15511874
22	NADH dehydrogenase complex assembly (GO:0010257)	4.15511874
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.15511874
24	ribonucleoprotein complex disassembly (GO:0032988)	4.11969961
25	transcytosis (GO:0045056)	4.09886588
26	positive regulation of meiotic cell cycle (GO:0051446)	3.98040527
27	lymphangiogenesis (GO:0001946)	3.95382847
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91994922
29	sister chromatid cohesion (GO:0007062)	3.82609346
30	synaptonemal complex assembly (GO:0007130)	3.72010827
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.70221286
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.70221286
33	synaptonemal complex organization (GO:0070193)	3.67605863
34	anterograde synaptic vesicle transport (GO:0048490)	3.64772082
35	establishment of viral latency (GO:0019043)	3.56355923
36	female gamete generation (GO:0007292)	3.48164738
37	reciprocal meiotic recombination (GO:0007131)	3.44965664
38	reciprocal DNA recombination (GO:0035825)	3.44965664
39	endothelial tube morphogenesis (GO:0061154)	3.43483212
40	morphogenesis of an endothelium (GO:0003159)	3.43483212
41	gene silencing by RNA (GO:0031047)	3.42017339
42	monoubiquitinated protein deubiquitination (GO:0035520)	3.39138750
43	resolution of meiotic recombination intermediates (GO:0000712)	3.29101826
44	chaperone-mediated protein transport (GO:0072321)	3.24194978
45	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.20816672
46	behavioral response to nicotine (GO:0035095)	3.19347001
47	oogenesis (GO:0048477)	3.17388686
48	organelle disassembly (GO:1903008)	3.15098898
49	meiotic cell cycle process (GO:1903046)	3.14369507
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.11709357
51	regulation of mitochondrial translation (GO:0070129)	3.07457890
52	platelet dense granule organization (GO:0060155)	3.06903600
53	ribosomal large subunit biogenesis (GO:0042273)	3.01531465
54	heart trabecula morphogenesis (GO:0061384)	2.99285029
55	DNA ligation (GO:0006266)	2.96725882
56	protein refolding (GO:0042026)	2.94859227
57	base-excision repair, AP site formation (GO:0006285)	2.94472137
58	protein maturation by protein folding (GO:0022417)	2.94147741
59	ribosomal small subunit assembly (GO:0000028)	2.93218485
60	ATP synthesis coupled proton transport (GO:0015986)	2.91919286
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.91919286
62	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.91737165
63	respiratory electron transport chain (GO:0022904)	2.90676644
64	negative regulation of meiosis (GO:0045835)	2.90428001
65	electron transport chain (GO:0022900)	2.89018160
66	intraciliary transport (GO:0042073)	2.88530505
67	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.88459258
68	protein neddylation (GO:0045116)	2.86128547
69	chaperone-mediated protein complex assembly (GO:0051131)	2.84984778
70	anterograde axon cargo transport (GO:0008089)	2.83105577
71	L-ascorbic acid metabolic process (GO:0019852)	2.79613392
72	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.79248967
73	tongue development (GO:0043586)	2.77755128
74	CENP-A containing nucleosome assembly (GO:0034080)	2.77604593
75	purine-containing compound salvage (GO:0043101)	2.75675418
76	chromatin remodeling at centromere (GO:0031055)	2.73541512
77	negative regulation of inclusion body assembly (GO:0090084)	2.72084049
78	Notch signaling involved in heart development (GO:0061314)	2.71299808
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70929518
80	regulation of meiotic cell cycle (GO:0051445)	2.70465829
81	histone exchange (GO:0043486)	2.70338358
82	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.69404162
83	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.69404162
84	isotype switching (GO:0045190)	2.69404162
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67168531
86	blood vessel maturation (GO:0001955)	2.66589404
87	epithelial cilium movement (GO:0003351)	2.66188869
88	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.66035688
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.63687687
90	detection of light stimulus involved in visual perception (GO:0050908)	2.63687687
91	meiotic cell cycle (GO:0051321)	2.63149072
92	purine deoxyribonucleotide catabolic process (GO:0009155)	2.62273057
93	aldehyde catabolic process (GO:0046185)	2.62028880
94	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.59871007
95	oxidative phosphorylation (GO:0006119)	2.59428082
96	motile cilium assembly (GO:0044458)	2.57694689
97	ventricular cardiac muscle cell development (GO:0055015)	2.57494803
98	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.53614330
99	response to X-ray (GO:0010165)	2.52247777
100	piRNA metabolic process (GO:0034587)	10.4840007

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.53205381
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47895305
3	VDR_22108803_ChIP-Seq_LS180_Human	3.31537662
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55930693
5	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.46436468
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.44537600
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42144045
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.41338159
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.32477503
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30915591
11	EWS_26573619_Chip-Seq_HEK293_Human	2.28858381
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.25135827
13	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.24501873
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24389767
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23348119
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15036412
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14347146
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13936610
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.07884808
20	FUS_26573619_Chip-Seq_HEK293_Human	2.02095843
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93225094
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.87922970
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.87922970
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.87922970
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86176706
26	RNF2_27304074_Chip-Seq_NSC_Mouse	1.84052133
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83715949
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.80420812
29	P300_19829295_ChIP-Seq_ESCs_Human	1.77274433
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74781533
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73024524
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67053351
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.63133916
34	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.61887619
35	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.59283340
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58403580
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.58268682
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58007254
39	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.56278821
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.53428733
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.51414021
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51414021
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51269919
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51269919
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.51196481
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48641548
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44479313
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43836387
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.40968355
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40642016
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.40183774
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.39204306
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37276455
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37246210
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36645145
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.36247413
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32807119
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31466209
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31347422
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.29802918
61	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.29673965
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29002122
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29002122
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28121659
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.27394727
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27391667
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.26304841
68	AR_20517297_ChIP-Seq_VCAP_Human	1.26027569
69	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25156659
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24041198
71	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.23481587
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23262027
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.23156915
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.22263861
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19673416
76	AR_25329375_ChIP-Seq_VCAP_Human	1.18015718
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.17341649
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16333031
79	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14538822
80	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14109482
81	CBP_21632823_ChIP-Seq_H3396_Human	1.13710600
82	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.10522064
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09903682
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09647850
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07063336
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06812301
87	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02383627
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01359559
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00291401
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.99902508
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98775837
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98419987
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97486972
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96494064
95	GABP_19822575_ChIP-Seq_HepG2_Human	0.95762305
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95747872
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95746245
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.95521810
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94623044
100	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94564701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	6.12784820
2	MP0008877_abnormal_DNA_methylation	4.64618265
3	MP0008058_abnormal_DNA_repair	3.42048085
4	MP0001879_abnormal_lymphatic_vessel	3.42024253
5	MP0003880_abnormal_central_pattern	2.89598685
6	MP0004147_increased_porphyrin_level	2.88739047
7	MP0000516_abnormal_urinary_system	2.43203253
8	MP0005367_renal/urinary_system_phenotyp	2.43203253
9	MP0001529_abnormal_vocalization	2.30595772
10	MP0002160_abnormal_reproductive_system	2.26428759
11	MP0000383_abnormal_hair_follicle	2.23324643
12	MP0003123_paternal_imprinting	2.21753716
13	MP0004885_abnormal_endolymph	2.19677829
14	MP0008004_abnormal_stomach_pH	2.18074941
15	MP0006054_spinal_hemorrhage	2.14920169
16	MP0005167_abnormal_blood-brain_barrier	2.09637477
17	MP0003718_maternal_effect	2.02007852
18	MP0002009_preneoplasia	2.00354601
19	MP0002210_abnormal_sex_determination	1.92662194
20	MP0003806_abnormal_nucleotide_metabolis	1.88321726
21	MP0006035_abnormal_mitochondrial_morpho	1.87553946
22	MP0001486_abnormal_startle_reflex	1.86937930
23	MP0008872_abnormal_physiological_respon	1.82995969
24	MP0005084_abnormal_gallbladder_morpholo	1.81725321
25	MP0001929_abnormal_gametogenesis	1.80334277
26	MP0010030_abnormal_orbit_morphology	1.74964634
27	MP0005389_reproductive_system_phenotype	1.71646929
28	MP0001145_abnormal_male_reproductive	1.68623017
29	MP0010094_abnormal_chromosome_stability	1.67833519
30	MP0002638_abnormal_pupillary_reflex	1.66202594
31	MP0006072_abnormal_retinal_apoptosis	1.62669062
32	MP0000653_abnormal_sex_gland	1.61162112
33	MP0002102_abnormal_ear_morphology	1.59071684
34	MP0003787_abnormal_imprinting	1.58947158
35	MP0010386_abnormal_urinary_bladder	1.56655643
36	MP0006276_abnormal_autonomic_nervous	1.54800665
37	MP0003136_yellow_coat_color	1.49651479
38	MP0006292_abnormal_olfactory_placode	1.48262241
39	MP0002837_dystrophic_cardiac_calcinosis	1.47505514
40	MP0000647_abnormal_sebaceous_gland	1.45493011
41	MP0003186_abnormal_redox_activity	1.44742858
42	MP0004215_abnormal_myocardial_fiber	1.43297684
43	MP0003567_abnormal_fetal_cardiomyocyte	1.41699034
44	MP0003698_abnormal_male_reproductive	1.41569328
45	MP0004142_abnormal_muscle_tone	1.37327481
46	MP0002822_catalepsy	1.36300617
47	MP0000427_abnormal_hair_cycle	1.36021309
48	MP0005671_abnormal_response_to	1.30643208
49	MP0006036_abnormal_mitochondrial_physio	1.26903904
50	MP0010678_abnormal_skin_adnexa	1.26381729
51	MP0005551_abnormal_eye_electrophysiolog	1.24604421
52	MP0004742_abnormal_vestibular_system	1.19844658
53	MP0005646_abnormal_pituitary_gland	1.13197595
54	MP0003121_genomic_imprinting	1.07520949
55	MP0005386_behavior/neurological_phenoty	1.04250919
56	MP0004924_abnormal_behavior	1.04250919
57	MP0002163_abnormal_gland_morphology	1.02457742
58	MP0000372_irregular_coat_pigmentation	1.01408254
59	MP0000579_abnormal_nail_morphology	0.97656149
60	MP0008789_abnormal_olfactory_epithelium	0.95979315
61	MP0009780_abnormal_chondrocyte_physiolo	0.93557456
62	MP0000358_abnormal_cell_content/	0.92580639
63	MP0008875_abnormal_xenobiotic_pharmacok	0.92550880
64	MP0001501_abnormal_sleep_pattern	0.92418559
65	MP0002736_abnormal_nociception_after	0.92173153
66	MP0001970_abnormal_pain_threshold	0.86163345
67	MP0001984_abnormal_olfaction	0.84660331
68	MP0002006_tumorigenesis	0.83782553
69	MP0005187_abnormal_penis_morphology	0.83431604
70	MP0005409_darkened_coat_color	0.83007974
71	MP0001119_abnormal_female_reproductive	0.82918939
72	MP0003119_abnormal_digestive_system	0.82558794
73	MP0001968_abnormal_touch/_nociception	0.81600023
74	MP0005365_abnormal_bile_salt	0.80016509
75	MP0002127_abnormal_cardiovascular_syste	0.79511163
76	MP0000465_gastrointestinal_hemorrhage	0.78033572
77	MP0003315_abnormal_perineum_morphology	0.77201291
78	MP0009745_abnormal_behavioral_response	0.76202112
79	MP0003937_abnormal_limbs/digits/tail_de	0.75960333
80	MP0003195_calcinosis	0.75429500
81	MP0005535_abnormal_body_temperature	0.75042214
82	MP0003137_abnormal_impulse_conducting	0.74856243
83	MP0005330_cardiomyopathy	0.74496493
84	MP0005395_other_phenotype	0.74326047
85	MP0002693_abnormal_pancreas_physiology	0.73889200
86	MP0002295_abnormal_pulmonary_circulatio	0.73702894
87	MP0005253_abnormal_eye_physiology	0.73141173
88	MP0002272_abnormal_nervous_system	0.72269079
89	MP0005645_abnormal_hypothalamus_physiol	0.70867147
90	MP0009764_decreased_sensitivity_to	0.68466377
91	MP0002095_abnormal_skin_pigmentation	0.67848099
92	MP0001919_abnormal_reproductive_system	0.66267351
93	MP0003646_muscle_fatigue	0.65431969
94	MP0005174_abnormal_tail_pigmentation	0.65063471
95	MP0000631_abnormal_neuroendocrine_gland	0.62855032
96	MP0002733_abnormal_thermal_nociception	0.62372255
97	MP0000569_abnormal_digit_pigmentation	0.62060457
98	MP0001944_abnormal_pancreas_morphology	0.61194466
99	MP0002557_abnormal_social/conspecific_i	0.60489312
100	MP0003638_abnormal_response/metabolism_	0.60387512

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.67980781
2	Acute necrotizing encephalopathy (HP:0006965)	4.62070022
3	Progressive macrocephaly (HP:0004481)	4.36833578
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.36474152
5	Acute encephalopathy (HP:0006846)	4.00388652
6	Mitochondrial inheritance (HP:0001427)	3.88393121
7	Hepatocellular necrosis (HP:0001404)	3.68145843
8	Increased CSF lactate (HP:0002490)	3.64841527
9	Hypothermia (HP:0002045)	3.60235697
10	Hepatic necrosis (HP:0002605)	3.51595106
11	Amyotrophic lateral sclerosis (HP:0007354)	3.40876929
12	Cerebral edema (HP:0002181)	3.31995131
13	Shoulder girdle muscle weakness (HP:0003547)	3.30025086
14	Volvulus (HP:0002580)	3.26922771
15	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.03703939
16	Increased hepatocellular lipid droplets (HP:0006565)	3.02218069
17	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.95905351
18	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.95905351
19	Lipid accumulation in hepatocytes (HP:0006561)	2.94547953
20	Rimmed vacuoles (HP:0003805)	2.89427098
21	Reticulocytopenia (HP:0001896)	2.87120840
22	Azoospermia (HP:0000027)	2.73194540
23	Capillary hemangiomas (HP:0005306)	2.65061442
24	Hypomagnesemia (HP:0002917)	2.64551011
25	Hemiparesis (HP:0001269)	2.61092669
26	Type I transferrin isoform profile (HP:0003642)	2.53915816
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.53341612
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.53341612
29	Abnormality of the lower motor neuron (HP:0002366)	2.51078116
30	Hyperglycinemia (HP:0002154)	2.49959683
31	Dyskinesia (HP:0100660)	2.49075743
32	Paralysis (HP:0003470)	2.48166788
33	Ectopic kidney (HP:0000086)	2.45677168
34	Chromsome breakage (HP:0040012)	2.43270284
35	Medial flaring of the eyebrow (HP:0010747)	2.41771297
36	Abnormal spermatogenesis (HP:0008669)	2.37369163
37	Abnormality of the corticospinal tract (HP:0002492)	2.36724894
38	Renal Fanconi syndrome (HP:0001994)	2.36122013
39	Delayed CNS myelination (HP:0002188)	2.33052089
40	Respiratory failure (HP:0002878)	2.30161941
41	Optic disc pallor (HP:0000543)	2.21848994
42	Abnormality of DNA repair (HP:0003254)	2.21483775
43	Lethargy (HP:0001254)	2.18686352
44	Congenital primary aphakia (HP:0007707)	2.18129174
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.15369976
46	Nephronophthisis (HP:0000090)	2.15298786
47	Lactic acidosis (HP:0003128)	2.13956482
48	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.13922178
49	Hypoglycemic seizures (HP:0002173)	2.12873056
50	Abnormality of magnesium homeostasis (HP:0004921)	2.11725161
51	Abnormality of midbrain morphology (HP:0002418)	2.10109486
52	Molar tooth sign on MRI (HP:0002419)	2.10109486
53	Gait imbalance (HP:0002141)	2.09469758
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07920274
55	Abnormality of the renal collecting system (HP:0004742)	2.07209511
56	Increased serum lactate (HP:0002151)	2.06889915
57	Ketoacidosis (HP:0001993)	2.06859856
58	Leukodystrophy (HP:0002415)	2.03366839
59	Increased intramyocellular lipid droplets (HP:0012240)	2.00769923
60	Petechiae (HP:0000967)	2.00090193
61	Congenital stationary night blindness (HP:0007642)	1.99805314
62	Dry hair (HP:0011359)	1.99415019
63	Absent/shortened dynein arms (HP:0200106)	1.98973951
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98973951
65	Exercise intolerance (HP:0003546)	1.98370156
66	Upper motor neuron abnormality (HP:0002127)	1.98017500
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.96723799
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.96723799
69	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96677737
70	Woolly hair (HP:0002224)	1.96635668
71	Abnormality of the renal medulla (HP:0100957)	1.96265591
72	Short middle phalanx of the 5th finger (HP:0004220)	1.92434813
73	Inappropriate behavior (HP:0000719)	1.91917263
74	Morphological abnormality of the pyramidal tract (HP:0002062)	1.91634365
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.91310569
76	Abnormal protein glycosylation (HP:0012346)	1.91310569
77	Abnormal glycosylation (HP:0012345)	1.91310569
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91310569
79	Duplicated collecting system (HP:0000081)	1.88126225
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.87899236
81	Oligodactyly (hands) (HP:0001180)	1.87634911
82	Alveolar cell carcinoma (HP:0006519)	1.87102143
83	Gonadotropin excess (HP:0000837)	1.87029678
84	Hematochezia (HP:0002573)	1.86713219
85	Supernumerary spleens (HP:0009799)	1.86139352
86	Abnormal ciliary motility (HP:0012262)	1.85937851
87	Conical tooth (HP:0000698)	1.85862649
88	Abnormality of renal resorption (HP:0011038)	1.84344190
89	Exertional dyspnea (HP:0002875)	1.83759596
90	Tubulointerstitial nephritis (HP:0001970)	1.83394623
91	Nephrogenic diabetes insipidus (HP:0009806)	1.83359499
92	Hypokalemic alkalosis (HP:0001949)	1.81805932
93	Abnormality of the labia minora (HP:0012880)	1.81506344
94	Neoplasm of the tracheobronchial system (HP:0100552)	1.81022357
95	Abdominal situs inversus (HP:0003363)	1.79610256
96	Abnormality of abdominal situs (HP:0011620)	1.79610256
97	Chronic bronchitis (HP:0004469)	1.77590161
98	True hermaphroditism (HP:0010459)	1.77357221
99	Reduced antithrombin III activity (HP:0001976)	1.76982422
100	Congenital ichthyosiform erythroderma (HP:0007431)	1.76568676

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	5.12206317
2	PNCK	4.81262751
3	CDK19	3.94094749
4	STK16	3.79916977
5	MST4	3.52352125
6	EPHB2	3.41849006
7	MAP3K12	2.97306463
8	BMPR2	2.75834052
9	NUAK1	2.46204896
10	FRK	2.45041248
11	ZAK	2.33929874
12	STK38L	2.00593719
13	BCKDK	1.92112340
14	TAOK3	1.60785451
15	STK39	1.53893890
16	TSSK6	1.51470662
17	WEE1	1.46168067
18	EPHA4	1.44557615
19	OXSR1	1.27196120
20	VRK1	1.26607632
21	WNK3	1.23345875
22	MYLK	1.22473213
23	MAPK15	1.17593839
24	TIE1	1.16679215
25	GRK1	1.16313411
26	MATK	1.13253734
27	TEC	1.13175489
28	EIF2AK3	1.10940419
29	ADRBK2	1.08659763
30	PHKG1	1.06503143
31	PHKG2	1.06503143
32	ILK	1.03335425
33	PASK	1.00841634
34	CDK8	0.96330198
35	VRK2	0.95249227
36	IRAK1	0.91622305
37	PINK1	0.89721564
38	DAPK3	0.84867300
39	KIT	0.84554910
40	TLK1	0.83252239
41	MAPK13	0.82706770
42	WNK4	0.78339300
43	CSNK1G2	0.76954686
44	DYRK2	0.72186623
45	LIMK1	0.71398151
46	ERBB3	0.71315975
47	NME2	0.71228606
48	TAOK1	0.71051005
49	FGFR3	0.70281047
50	TESK1	0.69373714
51	STK3	0.66452407
52	GRK7	0.66093752
53	EPHA3	0.65912031
54	CDK3	0.64687703
55	RPS6KA5	0.63632758
56	CSF1R	0.63387737
57	INSRR	0.63081002
58	NLK	0.62580335
59	CSNK1G1	0.62517980
60	MKNK1	0.61180064
61	FLT3	0.61036442
62	DAPK1	0.60565339
63	PRKCE	0.55851504
64	EGFR	0.50913535
65	ATM	0.50227425
66	PLK3	0.49890217
67	FGFR2	0.48446643
68	CSNK1G3	0.47983381
69	BCR	0.45763929
70	ROCK1	0.45584266
71	FGR	0.44292859
72	ITK	0.44036083
73	PDK2	0.43385479
74	PLK2	0.43267046
75	ADRBK1	0.41847205
76	MAPKAPK5	0.41613551
77	IGF1R	0.40037952
78	STK38	0.39645621
79	EIF2AK1	0.38637677
80	ATR	0.38621564
81	CSNK2A2	0.38280414
82	PLK4	0.36539893
83	TTK	0.36276506
84	STK24	0.36083981
85	PRKACB	0.35835708
86	ABL1	0.34564073
87	DYRK1A	0.33981681
88	PRKCG	0.33670676
89	IRAK2	0.33133622
90	PRKG1	0.30123710
91	BMX	0.28627533
92	EIF2AK2	0.27725213
93	AURKA	0.27693239
94	PRKCQ	0.27611260
95	PLK1	0.27220255
96	AURKB	0.27199621
97	OBSCN	0.25645081
98	BMPR1B	0.25251430
99	CSNK1A1	0.25128247
100	DAPK2	0.25075110

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.63020717
2	Asthma_Homo sapiens_hsa05310	3.27450374
3	Proteasome_Homo sapiens_hsa03050	3.19286742
4	Parkinsons disease_Homo sapiens_hsa05012	3.13798241
5	Non-homologous end-joining_Homo sapiens_hsa03450	3.08575894
6	Protein export_Homo sapiens_hsa03060	3.02111936
7	Ribosome_Homo sapiens_hsa03010	2.63163813
8	Regulation of autophagy_Homo sapiens_hsa04140	2.28363721
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.25034527
10	Homologous recombination_Homo sapiens_hsa03440	2.18392453
11	Base excision repair_Homo sapiens_hsa03410	2.11132774
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10101456
13	Huntingtons disease_Homo sapiens_hsa05016	2.09409984
14	Allograft rejection_Homo sapiens_hsa05330	2.08959165
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99712114
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.98620832
17	Alzheimers disease_Homo sapiens_hsa05010	1.98411834
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.98066206
19	Phototransduction_Homo sapiens_hsa04744	1.84824929
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84233114
21	Basal transcription factors_Homo sapiens_hsa03022	1.81170707
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.79256835
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70681887
24	RNA degradation_Homo sapiens_hsa03018	1.67637823
25	Mismatch repair_Homo sapiens_hsa03430	1.56020390
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.54547706
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53688122
28	DNA replication_Homo sapiens_hsa03030	1.48015235
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41473628
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.38687628
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36805701
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.31564562
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.29056159
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23712110
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22899504
36	Propanoate metabolism_Homo sapiens_hsa00640	1.21095942
37	Sulfur relay system_Homo sapiens_hsa04122	1.14672210
38	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.14490855
39	Folate biosynthesis_Homo sapiens_hsa00790	1.08906862
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07983975
41	Fatty acid elongation_Homo sapiens_hsa00062	1.06046296
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04141385
43	Viral myocarditis_Homo sapiens_hsa05416	1.01456736
44	RNA transport_Homo sapiens_hsa03013	0.99648278
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99427274
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96331696
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.87853334
48	Butanoate metabolism_Homo sapiens_hsa00650	0.86519613
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84202472
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.83502080
51	One carbon pool by folate_Homo sapiens_hsa00670	0.81432679
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80459906
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79745587
54	Fatty acid degradation_Homo sapiens_hsa00071	0.78845759
55	Nicotine addiction_Homo sapiens_hsa05033	0.76162375
56	RNA polymerase_Homo sapiens_hsa03020	0.75868445
57	Legionellosis_Homo sapiens_hsa05134	0.73542559
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72864454
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72717990
60	Purine metabolism_Homo sapiens_hsa00230	0.70003561
61	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69552305
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68191982
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.67885335
64	Cell cycle_Homo sapiens_hsa04110	0.61442652
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58850511
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55365045
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52431949
68	Olfactory transduction_Homo sapiens_hsa04740	0.49854005
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48723326
70	Spliceosome_Homo sapiens_hsa03040	0.47846587
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47668725
72	Oocyte meiosis_Homo sapiens_hsa04114	0.47280885
73	Insulin secretion_Homo sapiens_hsa04911	0.47259161
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.45759817
75	Metabolic pathways_Homo sapiens_hsa01100	0.44269264
76	Leishmaniasis_Homo sapiens_hsa05140	0.43028701
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42607139
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38702763
79	Circadian rhythm_Homo sapiens_hsa04710	0.38550924
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37973462
81	Alcoholism_Homo sapiens_hsa05034	0.37095649
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.36614418
83	Peroxisome_Homo sapiens_hsa04146	0.36393019
84	p53 signaling pathway_Homo sapiens_hsa04115	0.33218812
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33106384
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31745880
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.31288882
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31282211
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30360062
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.30254281
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30127200
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.27255815
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27141361
94	Phagosome_Homo sapiens_hsa04145	0.25433389
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.25280449
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.23862390
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23737468
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22641379
99	Retinol metabolism_Homo sapiens_hsa00830	0.20681776
100	Caffeine metabolism_Homo sapiens_hsa00232	0.20383486

ZFAND6P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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