ZFAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)7.78927569
2regulation of B cell receptor signaling pathway (GO:0050855)6.19578572
3B cell receptor signaling pathway (GO:0050853)5.16830779
4protein localization to kinetochore (GO:0034501)5.01738110
5nuclear pore organization (GO:0006999)4.54453832
6nuclear pore complex assembly (GO:0051292)4.40977670
7positive regulation of gamma-delta T cell activation (GO:0046645)4.32711274
8protein localization to chromosome, centromeric region (GO:0071459)4.21220173
9CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.18636351
10cellular response to ethanol (GO:0071361)4.06518650
11mitotic chromosome condensation (GO:0007076)4.05839610
12T cell lineage commitment (GO:0002360)3.99138007
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.92801108
14sister chromatid segregation (GO:0000819)3.89385815
15mitotic sister chromatid segregation (GO:0000070)3.84918032
16attachment of spindle microtubules to kinetochore (GO:0008608)3.79724604
17regulation of gonadotropin secretion (GO:0032276)3.63194664
18B cell proliferation (GO:0042100)3.61780017
19mitotic nuclear envelope disassembly (GO:0007077)3.60069704
20establishment of protein localization to Golgi (GO:0072600)3.56645914
21B cell homeostasis (GO:0001782)3.55752661
22female pregnancy (GO:0007565)3.51233008
23pore complex assembly (GO:0046931)3.50414883
24regulation of gamma-delta T cell activation (GO:0046643)3.47590474
25interkinetic nuclear migration (GO:0022027)3.46469159
26negative regulation of B cell proliferation (GO:0030889)3.43711649
27negative regulation of histone methylation (GO:0031061)3.43565549
28response to type I interferon (GO:0034340)3.41816189
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.41535866
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41535866
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41535866
32type I interferon signaling pathway (GO:0060337)3.40057806
33cellular response to type I interferon (GO:0071357)3.40057806
34positive regulation of B cell differentiation (GO:0045579)3.39441737
35JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.38342016
36heterochromatin organization (GO:0070828)3.34777599
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34675696
38membrane disassembly (GO:0030397)3.34630861
39nuclear envelope disassembly (GO:0051081)3.34630861
40positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.34143582
41kinetochore organization (GO:0051383)3.33964923
42pre-miRNA processing (GO:0031054)3.32497526
43T-helper 1 type immune response (GO:0042088)3.30798184
44T cell migration (GO:0072678)3.30201094
45dosage compensation (GO:0007549)3.29564643
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29390689
47antigen processing and presentation of endogenous antigen (GO:0019883)3.28186873
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27852811
49protein targeting to Golgi (GO:0000042)3.26420084
50androgen biosynthetic process (GO:0006702)3.25734447
51regulation of B cell differentiation (GO:0045577)3.22152904
52mitotic metaphase plate congression (GO:0007080)3.20949599
53DNA unwinding involved in DNA replication (GO:0006268)3.19984253
54germinal center formation (GO:0002467)3.18812048
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.18549681
56DNA replication-dependent nucleosome assembly (GO:0006335)3.15529167
57DNA replication-dependent nucleosome organization (GO:0034723)3.15529167
58DNA geometric change (GO:0032392)3.15310704
59prostate gland growth (GO:0060736)3.14645474
60meiotic chromosome segregation (GO:0045132)3.14427687
61positive regulation of chromosome segregation (GO:0051984)3.14042387
62immunoglobulin mediated immune response (GO:0016064)3.13435886
63regulation of alpha-beta T cell proliferation (GO:0046640)3.13104100
64regulation of histone H3-K9 methylation (GO:0051570)3.11355915
65negative thymic T cell selection (GO:0045060)3.09839133
66DNA duplex unwinding (GO:0032508)3.08950859
67retrograde transport, vesicle recycling within Golgi (GO:0000301)3.08882281
68regulation of spindle organization (GO:0090224)3.05064765
69metaphase plate congression (GO:0051310)3.04967306
70NLS-bearing protein import into nucleus (GO:0006607)3.04261306
71protein localization to chromosome (GO:0034502)3.03383789
72response to follicle-stimulating hormone (GO:0032354)3.02918929
73regulation of translational termination (GO:0006449)3.02877736
74DNA replication checkpoint (GO:0000076)3.02784502
75estrogen metabolic process (GO:0008210)3.02687463
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02502001
77positive regulation of developmental pigmentation (GO:0048087)3.02426412
78histone mRNA catabolic process (GO:0071044)3.02242384
79regulation of gamma-delta T cell differentiation (GO:0045586)3.00878896
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00592976
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.00205672
82regulation of mitotic spindle organization (GO:0060236)2.99443016
83regulation of interferon-gamma biosynthetic process (GO:0045072)2.98851441
84regulation of sister chromatid cohesion (GO:0007063)2.97326822
85DNA replication initiation (GO:0006270)2.96197815
86regulation of interferon-beta biosynthetic process (GO:0045357)2.95882333
87positive regulation of humoral immune response (GO:0002922)2.95726093
88interferon-gamma-mediated signaling pathway (GO:0060333)2.94743941
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93712841
90regulation of establishment of cell polarity (GO:2000114)2.92708371
91negative T cell selection (GO:0043383)2.91872680
92mitotic sister chromatid cohesion (GO:0007064)2.88549483
93IMP biosynthetic process (GO:0006188)2.87508624
94regulation of B cell proliferation (GO:0030888)2.87147900
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84727968
96response to interleukin-15 (GO:0070672)2.82709695
97histone H3-K9 methylation (GO:0051567)2.82578136
98histone H2A monoubiquitination (GO:0035518)2.82232313
99macrophage activation involved in immune response (GO:0002281)2.81805328
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80775757
101positive thymic T cell selection (GO:0045059)2.80686120
102positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79085992
103spindle assembly checkpoint (GO:0071173)2.77912681
104histone H3-K36 demethylation (GO:0070544)2.77832436
105spindle checkpoint (GO:0031577)2.77047985
106regulation of gene silencing by RNA (GO:0060966)2.76345281
107regulation of posttranscriptional gene silencing (GO:0060147)2.76345281
108regulation of gene silencing by miRNA (GO:0060964)2.76345281
109positive regulation of interferon-alpha production (GO:0032727)2.76183320
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76144876
111kinetochore assembly (GO:0051382)2.75630548
112homocysteine metabolic process (GO:0050667)2.74890664
113chromatin assembly (GO:0031497)2.74512235
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72531309
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.72531309
116modulation by symbiont of host immune response (GO:0052553)2.72531309
117positive regulation by symbiont of host defense response (GO:0052509)2.72531309
118modulation by symbiont of host defense response (GO:0052031)2.72531309
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72531309
120cellular response to interleukin-15 (GO:0071350)2.72110253
121chromosome segregation (GO:0007059)2.72043147
122hepatocyte apoptotic process (GO:0097284)2.71484700
123negative regulation of mast cell activation (GO:0033004)2.70873239
124DNA conformation change (GO:0071103)2.70622006
125negative regulation of viral release from host cell (GO:1902187)2.66756556
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66322456
127positive regulation of growth hormone secretion (GO:0060124)2.66202425
128NIK/NF-kappaB signaling (GO:0038061)2.65719430
129lymphocyte homeostasis (GO:0002260)2.65207523
130regulation of telomere maintenance via telomerase (GO:0032210)2.64470831
131chromatin assembly or disassembly (GO:0006333)2.64129754
132negative regulation of chromosome segregation (GO:0051985)2.63876228
133establishment of chromosome localization (GO:0051303)2.63374299
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63157383
135response to host immune response (GO:0052572)2.63157383
136regulation of chromosome segregation (GO:0051983)2.62595915
137protein K48-linked deubiquitination (GO:0071108)2.60260740
138histone H3-K4 methylation (GO:0051568)2.59935626
139regulation of interleukin-13 production (GO:0032656)2.59193953
140nuclear envelope organization (GO:0006998)2.59152280
141microtubule nucleation (GO:0007020)2.59005503
142regulation of interferon-alpha production (GO:0032647)2.58561093
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58330539
144chromosome condensation (GO:0030261)2.57073597
145oocyte development (GO:0048599)2.56582675
146regulation of NFAT protein import into nucleus (GO:0051532)2.56477390
147regulation of mitotic sister chromatid separation (GO:0010965)2.56127954
148regulation of mitotic sister chromatid segregation (GO:0033047)2.56127954
149regulation of sister chromatid segregation (GO:0033045)2.56127954
150regulation of centrosome cycle (GO:0046605)2.56052648
151histone H3-K9 modification (GO:0061647)2.55881094
152barbed-end actin filament capping (GO:0051016)2.55549125
153substrate-dependent cell migration (GO:0006929)2.55253691
154IMP metabolic process (GO:0046040)2.54560557
155multi-multicellular organism process (GO:0044706)2.54363704
156B cell mediated immunity (GO:0019724)2.53970561
157regulation of SMAD protein import into nucleus (GO:0060390)2.53843761
158regulation of centriole replication (GO:0046599)2.53569499
159mitotic spindle assembly checkpoint (GO:0007094)2.52869106
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.52735285
161negative regulation of mitotic sister chromatid separation (GO:2000816)2.52673872
162negative regulation of mitotic sister chromatid segregation (GO:0033048)2.52673872
163negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.52673872
164negative regulation of sister chromatid segregation (GO:0033046)2.52673872
165positive regulation of SMAD protein import into nucleus (GO:0060391)2.52462812
166histone H2A acetylation (GO:0043968)2.51553109
167peptidyl-lysine methylation (GO:0018022)2.51449904
168mitotic recombination (GO:0006312)2.51238482
169positive regulation of interleukin-4 production (GO:0032753)2.50836774
170folic acid-containing compound biosynthetic process (GO:0009396)2.49822151
171positive regulation of Rab GTPase activity (GO:0032851)2.49041933
172regulation of Rab GTPase activity (GO:0032313)2.49041933
173multicellular organism reproduction (GO:0032504)2.48879121
174histone H3-K4 trimethylation (GO:0080182)2.48759569
175phosphatidylethanolamine biosynthetic process (GO:0006646)2.48584410
176sphingoid metabolic process (GO:0046519)2.48435076
177monoubiquitinated protein deubiquitination (GO:0035520)2.47508438
178DNA replication-independent nucleosome organization (GO:0034724)2.47320020
179DNA replication-independent nucleosome assembly (GO:0006336)2.47320020
180peptidyl-lysine trimethylation (GO:0018023)2.46654099
181cellular response to nitric oxide (GO:0071732)2.46589020
182regulation of establishment or maintenance of cell polarity (GO:0032878)2.46385111
183thymic T cell selection (GO:0045061)2.44978531
184DNA packaging (GO:0006323)2.44795459
185positive T cell selection (GO:0043368)2.44783982
186antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44341301
187regulation of MHC class I biosynthetic process (GO:0045343)2.43796635
188glucocorticoid biosynthetic process (GO:0006704)2.39939966
189negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39905771
190negative regulation of cell killing (GO:0031342)2.39905771
191regulation of B cell activation (GO:0050864)2.37150472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.92345460
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.91129915
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.90565099
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75966236
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.25914785
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02050345
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00740835
8MYC_22102868_ChIP-Seq_BL_Human2.70607306
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59100144
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47015189
11RUNX_20019798_ChIP-Seq_JUKART_Human2.41098190
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.13941440
13* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.13476885
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10143909
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.08066633
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.02150029
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.02067469
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.01011437
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00818999
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00379955
21AR_21909140_ChIP-Seq_LNCAP_Human1.96284931
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.88667086
23GATA3_27048872_Chip-Seq_THYMUS_Human1.86043115
24VDR_21846776_ChIP-Seq_THP-1_Human1.77282268
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74149206
26CIITA_25753668_ChIP-Seq_RAJI_Human1.73557047
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72535536
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72415547
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71369670
30* VDR_24787735_ChIP-Seq_THP-1_Human1.68763868
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62430456
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61671821
33TFEB_21752829_ChIP-Seq_HELA_Human1.56444629
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55039412
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50722250
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50675697
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49399691
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49399691
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49399691
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47238247
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.47119904
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47044010
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46822887
44SMRT_27268052_Chip-Seq_Bcells_Human1.46201281
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45307834
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.44086421
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42719687
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39802931
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39094595
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38651692
51ER_23166858_ChIP-Seq_MCF-7_Human1.37688029
52AHR_22903824_ChIP-Seq_MCF-7_Human1.37095577
53GATA3_26560356_Chip-Seq_TH2_Human1.36759000
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36470900
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36449321
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.35593733
57AR_21572438_ChIP-Seq_LNCaP_Human1.35170865
58KDM5A_27292631_Chip-Seq_BREAST_Human1.34836841
59* VDR_24763502_ChIP-Seq_THP-1_Human1.32463446
60IRF1_19129219_ChIP-ChIP_H3396_Human1.32171949
61* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30783366
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30686221
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30399250
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29780239
65MAF_26560356_Chip-Seq_TH1_Human1.28975727
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28426689
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28296484
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.28029289
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27282927
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.26897359
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26746449
72MYB_26560356_Chip-Seq_TH1_Human1.23193166
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23168982
74UTX_26944678_Chip-Seq_JUKART_Human1.22202343
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21686064
76* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19777409
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.19317937
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18409524
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18117187
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17997226
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17275725
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17245650
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15046751
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13111585
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13111585
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12493722
87CBP_20019798_ChIP-Seq_JUKART_Human1.11287405
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11287405
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11097364
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10686720
91KDM2B_26808549_Chip-Seq_DND41_Human1.10281315
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10154996
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10115804
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.10075479
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.09367673
96STAT3_23295773_ChIP-Seq_U87_Human1.07598416
97* SPI1_23547873_ChIP-Seq_NB4_Human1.05971579
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.04583353
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02181032
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01886367
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01661295
102SPI1_23127762_ChIP-Seq_K562_Human1.01190651
103* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01088579
104GATA3_26560356_Chip-Seq_TH1_Human1.00226714
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99430694
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.98888701
107BRD4_25478319_ChIP-Seq_HGPS_Human0.98677572
108MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98345866
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98153024
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97818323
111GATA1_22025678_ChIP-Seq_K562_Human0.97404694
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97132862
113TCF4_23295773_ChIP-Seq_U87_Human0.97099064
114* GATA1_19941826_ChIP-Seq_K562_Human0.95789324
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95147998
116MYB_26560356_Chip-Seq_TH2_Human0.95040265
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94213002
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93858817
119* VDR_23849224_ChIP-Seq_CD4+_Human0.93807793
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93657491
121XRN2_22483619_ChIP-Seq_HELA_Human0.92811746
122MAF_26560356_Chip-Seq_TH2_Human0.92449105
123SCL_19346495_ChIP-Seq_HPC-7_Human0.92198571
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92180960
125TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92132979
126* P300_27268052_Chip-Seq_Bcells_Human0.91763983
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91619557
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90982524
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90970184
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.90807359
131* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90101122
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89303578
133NCOR1_26117541_ChIP-Seq_K562_Human0.89125677
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88885097
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88876151
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.88610268
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88444902
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88425864
139* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87553441
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87494752
141IGF1R_20145208_ChIP-Seq_DFB_Human0.87182031
142* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86650146
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86635521
144ZNF274_21170338_ChIP-Seq_K562_Hela0.86421617
145ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86389626
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86206104
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86000559
148FOXP3_21729870_ChIP-Seq_TREG_Human0.85586628
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.84716097
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84068799
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83923320
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83921618
153* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83294716
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83053274
155ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82827487
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81561540
157EGR1_19032775_ChIP-ChIP_M12_Human0.81137957
158BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.80349199
159* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79174253
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78788220
161* GATA2_19941826_ChIP-Seq_K562_Human0.78667620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.34304918
2MP0003111_abnormal_nucleus_morphology2.99828354
3MP0000372_irregular_coat_pigmentation2.84438784
4MP0003693_abnormal_embryo_hatching2.83916834
5MP0008057_abnormal_DNA_replication2.78148509
6MP0000569_abnormal_digit_pigmentation2.77170601
7MP0010352_gastrointestinal_tract_polyps2.73350903
8MP0008438_abnormal_cutaneous_collagen2.73073895
9MP0005076_abnormal_cell_differentiation2.72893227
10MP0010094_abnormal_chromosome_stability2.66024080
11MP0002166_altered_tumor_susceptibility2.65939836
12MP0005671_abnormal_response_to2.63905320
13MP0003077_abnormal_cell_cycle2.60121813
14MP0003890_abnormal_embryonic-extraembry2.54963779
15MP0003763_abnormal_thymus_physiology2.47249171
16MP0002163_abnormal_gland_morphology2.46031362
17MP0010307_abnormal_tumor_latency2.40673837
18MP0003705_abnormal_hypodermis_morpholog2.39253476
19MP0009278_abnormal_bone_marrow2.30614620
20MP0005310_abnormal_salivary_gland2.29960691
21MP0004957_abnormal_blastocyst_morpholog2.24870293
22MP0000015_abnormal_ear_pigmentation2.21728511
23MP0003045_fibrosis2.10107293
24MP0005379_endocrine/exocrine_gland_phen2.09624871
25MP0002138_abnormal_hepatobiliary_system2.08027029
26MP0004381_abnormal_hair_follicle2.07102854
27MP0008877_abnormal_DNA_methylation2.05929319
28MP0003950_abnormal_plasma_membrane2.03182043
29MP0005451_abnormal_body_composition2.03107041
30MP0005000_abnormal_immune_tolerance2.01555122
31MP0005645_abnormal_hypothalamus_physiol2.01531144
32MP0003121_genomic_imprinting1.92512334
33MP0005503_abnormal_tendon_morphology1.89644913
34MP0000350_abnormal_cell_proliferation1.88513006
35MP0008007_abnormal_cellular_replicative1.88157981
36MP0002006_tumorigenesis1.81843629
37MP0003566_abnormal_cell_adhesion1.80011602
38MP0005410_abnormal_fertilization1.68888928
39MP0005075_abnormal_melanosome_morpholog1.67019507
40MP0002396_abnormal_hematopoietic_system1.65708714
41MP0001730_embryonic_growth_arrest1.60493849
42MP0006054_spinal_hemorrhage1.55155013
43MP0001545_abnormal_hematopoietic_system1.53929923
44MP0005397_hematopoietic_system_phenotyp1.53929923
45MP0005380_embryogenesis_phenotype1.52139005
46MP0001672_abnormal_embryogenesis/_devel1.52139005
47MP0003646_muscle_fatigue1.48819179
48MP0003984_embryonic_growth_retardation1.47409855
49MP0009785_altered_susceptibility_to1.45547461
50MP0002088_abnormal_embryonic_growth/wei1.45301735
51MP0008058_abnormal_DNA_repair1.44592259
52MP0005025_abnormal_response_to1.43321551
53MP0003123_paternal_imprinting1.42255414
54MP0005023_abnormal_wound_healing1.41988540
55MP0008932_abnormal_embryonic_tissue1.40533384
56MP0004808_abnormal_hematopoietic_stem1.40374944
57MP0005647_abnormal_sex_gland1.39972605
58MP0002419_abnormal_innate_immunity1.39420163
59MP0009115_abnormal_fat_cell1.37740280
60MP0001915_intracranial_hemorrhage1.34588456
61* MP0002086_abnormal_extraembryonic_tissu1.33653667
62MP0000003_abnormal_adipose_tissue1.32327896
63MP0002877_abnormal_melanocyte_morpholog1.31960102
64MP0004197_abnormal_fetal_growth/weight/1.31008991
65MP0003115_abnormal_respiratory_system1.29852650
66MP0003091_abnormal_cell_migration1.28976852
67MP0010368_abnormal_lymphatic_system1.28235336
68MP0003303_peritoneal_inflammation1.26066474
69MP0001697_abnormal_embryo_size1.25917803
70MP0002085_abnormal_embryonic_tissue1.24906673
71MP0005464_abnormal_platelet_physiology1.23794365
72MP0005670_abnormal_white_adipose1.23413232
73MP0010030_abnormal_orbit_morphology1.22690522
74MP0000733_abnormal_muscle_development1.22246787
75MP0000013_abnormal_adipose_tissue1.18567573
76MP0003122_maternal_imprinting1.18282591
77* MP0002084_abnormal_developmental_patter1.17739388
78MP0006082_CNS_inflammation1.16382617
79MP0000685_abnormal_immune_system1.16160537
80MP0003183_abnormal_peptide_metabolism1.16112213
81MP0002405_respiratory_system_inflammati1.15049332
82MP0004510_myositis1.13655632
83MP0010155_abnormal_intestine_physiology1.13632316
84MP0002148_abnormal_hypersensitivity_rea1.12394479
85* MP0002080_prenatal_lethality1.12130428
86MP0003724_increased_susceptibility_to1.09438646
87MP0001835_abnormal_antigen_presentation1.09261563
88MP0000703_abnormal_thymus_morphology1.05907795
89MP0003300_gastrointestinal_ulcer1.05274857
90MP0001800_abnormal_humoral_immune1.03973664
91MP0002168_other_aberrant_phenotype1.02980423
92MP0005621_abnormal_cell_physiology1.02176766
93MP0002398_abnormal_bone_marrow1.01878753
94MP0000490_abnormal_crypts_of1.01094706
95MP0001845_abnormal_inflammatory_respons1.00983927
96MP0002452_abnormal_antigen_presenting1.00333368
97MP0000313_abnormal_cell_death0.99947302
98MP0005387_immune_system_phenotype0.99066354
99MP0001790_abnormal_immune_system0.99066354
100MP0000767_abnormal_smooth_muscle0.98858972
101MP0000371_diluted_coat_color0.98039301
102MP0002009_preneoplasia0.98008615
103MP0002095_abnormal_skin_pigmentation0.97540435
104MP0002876_abnormal_thyroid_physiology0.97282981
105MP0002332_abnormal_exercise_endurance0.96836626
106MP0003786_premature_aging0.96437741
107MP0003448_altered_tumor_morphology0.96394281
108MP0000428_abnormal_craniofacial_morphol0.95401544
109MP0005257_abnormal_intraocular_pressure0.93896633
110MP0002019_abnormal_tumor_incidence0.93422758
111MP0003828_pulmonary_edema0.92558087
112MP0003959_abnormal_lean_body0.91915056
113MP0002722_abnormal_immune_system0.91324348
114MP0002998_abnormal_bone_remodeling0.90928194
115MP0001348_abnormal_lacrimal_gland0.90345694
116MP0004947_skin_inflammation0.89987991
117MP0005384_cellular_phenotype0.89527405
118MP0004264_abnormal_extraembryonic_tissu0.88771690
119MP0001929_abnormal_gametogenesis0.88613403
120MP0001293_anophthalmia0.88566877
121MP0009764_decreased_sensitivity_to0.87337007
122MP0000689_abnormal_spleen_morphology0.86567110
123MP0005408_hypopigmentation0.86526326
124MP0005171_absent_coat_pigmentation0.86208031
125MP0002925_abnormal_cardiovascular_devel0.85433616
126MP0009333_abnormal_splenocyte_physiolog0.84671830
127MP0003136_yellow_coat_color0.84641079
128MP0001873_stomach_inflammation0.84457828
129MP0004272_abnormal_basement_membrane0.83873990
130MP0003567_abnormal_fetal_cardiomyocyte0.82971817
131MP0004233_abnormal_muscle_weight0.82492203
132MP0005508_abnormal_skeleton_morphology0.81778117
133MP0002697_abnormal_eye_size0.80751587
134MP0005266_abnormal_metabolism0.80609155
135MP0005174_abnormal_tail_pigmentation0.80513264
136MP0005375_adipose_tissue_phenotype0.80230380
137MP0002971_abnormal_brown_adipose0.78695965
138MP0003698_abnormal_male_reproductive0.78183519
139MP0003283_abnormal_digestive_organ0.78176582
140MP0002075_abnormal_coat/hair_pigmentati0.77684724
141MP0001175_abnormal_lung_morphology0.77343793
142MP0003172_abnormal_lysosome_physiology0.77300009
143MP0001819_abnormal_immune_cell0.76720779
144MP0001919_abnormal_reproductive_system0.76465355
145MP0003252_abnormal_bile_duct0.76406269
146MP0008961_abnormal_basal_metabolism0.75149289
147MP0000716_abnormal_immune_system0.74816161
148MP0002723_abnormal_immune_serum0.74415214
149MP0002420_abnormal_adaptive_immunity0.74408282
150MP0000858_altered_metastatic_potential0.74233541
151* MP0002429_abnormal_blood_cell0.74033985
152MP0000432_abnormal_head_morphology0.73793623
153MP0009703_decreased_birth_body0.73610612
154MP0003436_decreased_susceptibility_to0.73318120
155MP0004133_heterotaxia0.73170074
156MP0003868_abnormal_feces_composition0.73009628
157MP0002108_abnormal_muscle_morphology0.72846617
158MP0002132_abnormal_respiratory_system0.70550659
159MP0001186_pigmentation_phenotype0.66941021
160MP0003656_abnormal_erythrocyte_physiolo0.66440875
161MP0004145_abnormal_muscle_electrophysio0.64910498
162MP0005395_other_phenotype0.64229597

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)4.79528826
2Gastrointestinal stroma tumor (HP:0100723)4.66199899
3Agammaglobulinemia (HP:0004432)4.25575656
4Panhypogammaglobulinemia (HP:0003139)4.10635202
5Recurrent viral infections (HP:0004429)3.92257612
6Recurrent sinusitis (HP:0011108)3.82845934
7Abnormality of B cell number (HP:0010975)3.80363648
8B lymphocytopenia (HP:0010976)3.79937754
9IgM deficiency (HP:0002850)3.73005186
10Colitis (HP:0002583)3.65340257
11Hypoplasia of the thymus (HP:0000778)3.58026749
12Recurrent bronchitis (HP:0002837)3.53541941
13Meningitis (HP:0001287)3.47431137
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.45423583
15Lymphopenia (HP:0001888)3.40944185
16IgG deficiency (HP:0004315)3.29735417
17Recurrent fungal infections (HP:0002841)3.29007662
18Vasculitis (HP:0002633)3.26106924
19Basal cell carcinoma (HP:0002671)3.25019370
20Abnormality of cells of the lymphoid lineage (HP:0012140)3.22155106
21Abnormality of the fingertips (HP:0001211)3.11656362
22Ependymoma (HP:0002888)3.04145886
23Abnormality of T cell physiology (HP:0011840)3.02839610
24Chromsome breakage (HP:0040012)3.00625947
25Chronic hepatic failure (HP:0100626)3.00014108
26Abnormality of T cell number (HP:0011839)2.92818746
27Chronic diarrhea (HP:0002028)2.89215571
28T lymphocytopenia (HP:0005403)2.88983213
29Abnormality of T cells (HP:0002843)2.88815278
30Autoimmune hemolytic anemia (HP:0001890)2.88499966
31Cellulitis (HP:0100658)2.81473156
32Thyroiditis (HP:0100646)2.79616372
33Hypoproteinemia (HP:0003075)2.78755630
34Eosinophilia (HP:0001880)2.77316056
35Leiomyosarcoma (HP:0100243)2.75003044
36Uterine leiomyosarcoma (HP:0002891)2.75003044
37Inflammation of the large intestine (HP:0002037)2.74179131
38Hypergonadotropic hypogonadism (HP:0000815)2.72161461
39Capillary hemangiomas (HP:0005306)2.70552035
40Poikiloderma (HP:0001029)2.69689000
41Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.68330993
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65839555
43Long eyelashes (HP:0000527)2.65827926
44Ankle contracture (HP:0006466)2.65637386
45Emphysema (HP:0002097)2.60400374
46Urethral obstruction (HP:0000796)2.59568436
47Subacute progressive viral hepatitis (HP:0006572)2.59124526
48Malignant gastrointestinal tract tumors (HP:0006749)2.58780964
49Gastrointestinal carcinoma (HP:0002672)2.58780964
50Recurrent cutaneous fungal infections (HP:0011370)2.57877042
51Chronic mucocutaneous candidiasis (HP:0002728)2.57877042
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57455905
53Recurrent pneumonia (HP:0006532)2.57332300
54Granulocytopenia (HP:0001913)2.56797832
55Recurrent bacterial skin infections (HP:0005406)2.56629221
56Gastrointestinal inflammation (HP:0004386)2.55895200
57Astrocytoma (HP:0009592)2.54456663
58Abnormality of the astrocytes (HP:0100707)2.54456663
59Birth length less than 3rd percentile (HP:0003561)2.53606824
60Volvulus (HP:0002580)2.52592497
61Transitional cell carcinoma of the bladder (HP:0006740)2.51816364
62Abnormality of DNA repair (HP:0003254)2.49511200
63Spinal muscular atrophy (HP:0007269)2.46067745
64Osteomyelitis (HP:0002754)2.45393091
65Acute hepatic failure (HP:0006554)2.45247461
66Severe visual impairment (HP:0001141)2.44235534
67Restrictive lung disease (HP:0002091)2.43048057
68Protrusio acetabuli (HP:0003179)2.42240712
69Hematochezia (HP:0002573)2.41451940
70Vertebral compression fractures (HP:0002953)2.40979748
71Recurrent lower respiratory tract infections (HP:0002783)2.37222241
72Wrist flexion contracture (HP:0001239)2.36840974
73Eczematoid dermatitis (HP:0000976)2.36583356
74Bladder carcinoma (HP:0002862)2.36046808
75Bladder neoplasm (HP:0009725)2.36046808
76Severe combined immunodeficiency (HP:0004430)2.35951318
77Attenuation of retinal blood vessels (HP:0007843)2.31404287
78Premature rupture of membranes (HP:0001788)2.29746081
79Patellar aplasia (HP:0006443)2.28451646
80Gastrointestinal infarctions (HP:0005244)2.26094719
81Lymphoma (HP:0002665)2.24741851
82Abnormality of eosinophils (HP:0001879)2.24199656
83Entropion (HP:0000621)2.23667965
84Recurrent abscess formation (HP:0002722)2.21726115
85Albinism (HP:0001022)2.20059716
86Cervical subluxation (HP:0003308)2.19076078
87Medulloblastoma (HP:0002885)2.18824397
88Broad metatarsal (HP:0001783)2.16398756
89Dysmetric saccades (HP:0000641)2.14701675
90Skin tags (HP:0010609)2.13104326
91Chest pain (HP:0100749)2.11801623
92Broad thumb (HP:0011304)2.11130229
93Abnormality of the labia minora (HP:0012880)2.10245764
94Glioma (HP:0009733)2.09394013
95Ectopic kidney (HP:0000086)2.08331766
96Papilloma (HP:0012740)2.06085008
97Verrucae (HP:0200043)2.06085008
98Abnormality of the prostate (HP:0008775)2.05349161
99Leukocytosis (HP:0001974)2.05022583
100Cerebral aneurysm (HP:0004944)2.00911231
101Bronchitis (HP:0012387)2.00855921
102Aplasia/Hypoplasia of the thymus (HP:0010515)1.99921811
103Agnosia (HP:0010524)1.99360605
104Aplasia/Hypoplasia of the patella (HP:0006498)1.98775972
105Hand muscle atrophy (HP:0009130)1.98068997
106Preauricular skin tag (HP:0000384)1.98040634
107Upper limb muscle weakness (HP:0003484)1.97913404
108Increased nuchal translucency (HP:0010880)1.96526482
109Autoimmune thrombocytopenia (HP:0001973)1.96318404
110Elevated erythrocyte sedimentation rate (HP:0003565)1.96125956
111Hepatitis (HP:0012115)1.95953041
112Spontaneous hematomas (HP:0007420)1.95483090
113Renal cell carcinoma (HP:0005584)1.94874181
114Homocystinuria (HP:0002156)1.94490276
115Abnormality of homocysteine metabolism (HP:0010919)1.94490276
116Broad phalanges of the hand (HP:0009768)1.94446705
117Squamous cell carcinoma (HP:0002860)1.94097210
118Combined immunodeficiency (HP:0005387)1.93612597
119Glomerulonephritis (HP:0000099)1.90431538
120Abnormality of the ischium (HP:0003174)1.88987455
121Impulsivity (HP:0100710)1.88560958
122Delayed closure of the anterior fontanelle (HP:0001476)1.87991094
123Prominent nose (HP:0000448)1.87104826
124Recurrent skin infections (HP:0001581)1.86421681
125Congenital stationary night blindness (HP:0007642)1.85179870
126Reduced antithrombin III activity (HP:0001976)1.84402807
127Viral hepatitis (HP:0006562)1.83220995
128Neoplasm of the oral cavity (HP:0100649)1.82816893
129Urticaria (HP:0001025)1.82188944
130Anal stenosis (HP:0002025)1.81357779
131Hyperkalemia (HP:0002153)1.80322753
132Cutaneous melanoma (HP:0012056)1.80137999
133Gaze-evoked nystagmus (HP:0000640)1.79415323
134Renal duplication (HP:0000075)1.78936857
135Selective tooth agenesis (HP:0001592)1.78584707
136Heterotopia (HP:0002282)1.77643838
137Ocular albinism (HP:0001107)1.77518505
138Ulnar bowing (HP:0003031)1.76837923
139Clubbing of toes (HP:0100760)1.76235928
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.75972744
141Metaphyseal cupping (HP:0003021)1.74265065
142Sepsis (HP:0100806)1.73779151
143Pulmonary infiltrates (HP:0002113)1.73458944
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72497548
145Short 4th metacarpal (HP:0010044)1.72497548
146Upper limb amyotrophy (HP:0009129)1.71847679
147Distal upper limb amyotrophy (HP:0007149)1.71847679
148Fatigue (HP:0012378)1.71801396
149Aplasia/Hypoplasia of the macula (HP:0008059)1.71532448
150Amaurosis fugax (HP:0100576)1.71424496
151Abnormality of the thymus (HP:0000777)1.71306462
152Abnormality of chromosome stability (HP:0003220)1.70767928
153Bony spicule pigmentary retinopathy (HP:0007737)1.70741922
154Encephalitis (HP:0002383)1.70461592
155Abnormality of the radial head (HP:0003995)1.70436129
156Stomatitis (HP:0010280)1.70406313
157Flat capital femoral epiphysis (HP:0003370)1.69451842
158Hypoplastic ischia (HP:0003175)1.68501628
159Uterine neoplasm (HP:0010784)1.66994928
160Narrow palate (HP:0000189)1.66478312
161Broad finger (HP:0001500)1.65216627
162Limited elbow extension (HP:0001377)1.65112059
163Broad phalanx (HP:0006009)1.63836516
164Leukopenia (HP:0001882)1.63325954
165Trigonocephaly (HP:0000243)1.62098345
166Abnormality of the ileum (HP:0001549)1.61582384
167Small intestinal stenosis (HP:0012848)1.60182060
168Duodenal stenosis (HP:0100867)1.60182060
169High pitched voice (HP:0001620)1.60071285
170Nephroblastoma (Wilms tumor) (HP:0002667)1.60063013
171Shallow orbits (HP:0000586)1.59178778
172Broad palm (HP:0001169)1.58573297
173Intestinal fistula (HP:0100819)1.58189789
174Cafe-au-lait spot (HP:0000957)1.57381949
175Dislocated radial head (HP:0003083)1.56180629
176Prostate neoplasm (HP:0100787)1.53605755
177Deviation of the thumb (HP:0009603)1.52661838
178Soft skin (HP:0000977)1.51590440
179Mesomelia (HP:0003027)1.51395939
180Meckel diverticulum (HP:0002245)1.51282390
181Disproportionate tall stature (HP:0001519)1.51196330
182Broad long bones (HP:0005622)1.50649334
183Vertebral arch anomaly (HP:0008438)1.50550933
184Persistence of primary teeth (HP:0006335)1.50429155
185Short humerus (HP:0005792)1.50284452
186Bladder diverticulum (HP:0000015)1.48918613
187Neoplasm of the adrenal cortex (HP:0100641)1.48754785
188Neoplasm of striated muscle (HP:0009728)1.47651361
189Truncal obesity (HP:0001956)1.47087517
190Mediastinal lymphadenopathy (HP:0100721)1.47002479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.66737492
2CDK124.46566691
3BUB13.30434109
4RIPK42.84056713
5MAP3K102.82429110
6NEK22.71120474
7CDC72.69553545
8BLK2.67192869
9NEK92.57504246
10CAMK1D2.39530842
11PRPF4B2.08405559
12EIF2AK32.00312242
13LATS11.90250747
14PIK3CG1.85956962
15ERN11.80347176
16SYK1.78089896
17BTK1.65406212
18KDR1.63968927
19STK101.62095938
20CHEK21.60188722
21TTK1.60015920
22MAPK111.57967941
23CHUK1.51320672
24EEF2K1.50518319
25TGFBR11.44736611
26IRAK41.43502685
27TGFBR21.43337887
28SIK21.40567248
29RPS6KA41.39842793
30ACVR1B1.39656654
31AKT31.37244302
32TNK21.34330506
33ATR1.33362762
34INSRR1.33078932
35ICK1.30627750
36CDK41.29141651
37BRD41.28325238
38MAP4K11.27452379
39WEE11.25962905
40CSF1R1.25118224
41PLK11.24681985
42MTOR1.24421629
43STK41.24336537
44CAMK1G1.24244829
45MAP3K141.24025955
46STK31.23987189
47EPHA21.23635687
48JAK31.21700909
49TRPM71.15726654
50PRKD31.14931329
51SIK11.14509927
52MELK1.14475036
53SMG11.14298435
54PKN21.13354218
55CHEK11.12345317
56TYK21.11742479
57CDK71.11043988
58AURKB1.10984775
59PLK31.09123048
60PDK11.07238742
61IKBKB1.06642705
62STK38L1.06369141
63SIK31.04521313
64LYN1.03527364
65PTK2B1.02814473
66CCNB11.02300787
67MAP3K71.02140022
68PRKD21.01220103
69PIM10.99900737
70FLT30.98530718
71BMPR1B0.98333152
72TTN0.97297028
73TEC0.97275393
74CSK0.96691523
75ATM0.96601329
76MAP3K130.96466317
77SGK20.96151012
78MARK30.94633029
79EIF2AK10.94451828
80TSSK60.94332535
81EIF2AK20.93886914
82PTK60.92181792
83CDK60.92045296
84PDPK10.91857028
85CDK190.91424553
86BRSK20.90574061
87DYRK30.89587696
88IRAK10.88301427
89ERBB30.87878893
90FGFR30.85670465
91PINK10.85170678
92WNK10.84413790
93PRKCQ0.82589984
94CDK20.82103439
95JAK20.81460158
96ALK0.80934745
97PRKAA20.79324546
98GRK60.78884215
99PAK40.77877150
100BMX0.77600197
101MAP4K20.77329513
102ZAK0.76353799
103KIT0.75904697
104MAP3K80.75632211
105JAK10.75532234
106SCYL20.75120248
107NLK0.74097439
108MATK0.74022588
109TBK10.73807620
110OBSCN0.70917004
111TRIB30.69613431
112RPS6KB20.68584190
113MKNK10.66021041
114SRPK10.65683554
115CDC42BPA0.64514159
116TAOK20.63712843
117RPS6KA50.61957776
118LCK0.61935455
119PKN10.61071570
120MAPK120.60166683
121PRKAA10.59733343
122PDGFRA0.59678212
123TAOK30.59384701
124PLK40.59046722
125CDK10.57765286
126CAMK40.57450193
127PTK20.57325197
128RPS6KC10.55416568
129RPS6KL10.55416568
130DAPK20.54896586
131PASK0.53416153
132MAP2K30.52992540
133RPS6KA60.52816542
134ADRBK20.51941498
135BMPR20.51536469
136MAPK70.50375849
137TXK0.49908269
138RPS6KA20.49468663
139FGR0.49038480
140DMPK0.48588518
141NEK10.48588227
142IKBKE0.47684258
143AKT10.45204281
144TLK10.43925885
145DYRK1B0.42472983
146MAPK10.41226629
147SGK30.41090080
148MAPK140.41008316
149NUAK10.40625307
150ITK0.40527937
151MAPK100.40503867
152HCK0.40271437
153STK380.38740581

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.12071761
2Graft-versus-host disease_Homo sapiens_hsa053322.94148012
3DNA replication_Homo sapiens_hsa030302.47908305
4Type I diabetes mellitus_Homo sapiens_hsa049402.42576897
5Mismatch repair_Homo sapiens_hsa034302.40420957
6Cell cycle_Homo sapiens_hsa041102.38313104
7Asthma_Homo sapiens_hsa053102.30188404
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20881622
9RNA transport_Homo sapiens_hsa030131.94643439
10Base excision repair_Homo sapiens_hsa034101.88889108
11Ovarian steroidogenesis_Homo sapiens_hsa049131.88553918
12Non-homologous end-joining_Homo sapiens_hsa034501.68669189
13Lysine degradation_Homo sapiens_hsa003101.65455770
14One carbon pool by folate_Homo sapiens_hsa006701.64183872
15Homologous recombination_Homo sapiens_hsa034401.63797845
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63772814
17Viral carcinogenesis_Homo sapiens_hsa052031.61987809
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.61926063
19Spliceosome_Homo sapiens_hsa030401.61745456
20Small cell lung cancer_Homo sapiens_hsa052221.58462340
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57601073
22MicroRNAs in cancer_Homo sapiens_hsa052061.54582799
23p53 signaling pathway_Homo sapiens_hsa041151.53006789
24Fanconi anemia pathway_Homo sapiens_hsa034601.52244603
25Alcoholism_Homo sapiens_hsa050341.46825228
26Herpes simplex infection_Homo sapiens_hsa051681.41297463
27Antigen processing and presentation_Homo sapiens_hsa046121.36884970
28mTOR signaling pathway_Homo sapiens_hsa041501.36392684
29mRNA surveillance pathway_Homo sapiens_hsa030151.35800871
30Systemic lupus erythematosus_Homo sapiens_hsa053221.34367043
31HTLV-I infection_Homo sapiens_hsa051661.32809596
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.30628486
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26230181
34Epstein-Barr virus infection_Homo sapiens_hsa051691.24994387
35Apoptosis_Homo sapiens_hsa042101.23727422
36Leishmaniasis_Homo sapiens_hsa051401.23123537
37Measles_Homo sapiens_hsa051621.22833102
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21878359
39Influenza A_Homo sapiens_hsa051641.18170924
40Chronic myeloid leukemia_Homo sapiens_hsa052201.15669281
41Nucleotide excision repair_Homo sapiens_hsa034201.13402899
42Osteoclast differentiation_Homo sapiens_hsa043801.13243612
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13053150
44Proteoglycans in cancer_Homo sapiens_hsa052051.11019969
45Notch signaling pathway_Homo sapiens_hsa043301.10037692
46B cell receptor signaling pathway_Homo sapiens_hsa046621.08710968
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08220544
48Fatty acid biosynthesis_Homo sapiens_hsa000611.08050241
49Adherens junction_Homo sapiens_hsa045201.07477794
50Hepatitis B_Homo sapiens_hsa051611.05834255
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02748535
52Primary immunodeficiency_Homo sapiens_hsa053401.01250137
53RNA degradation_Homo sapiens_hsa030181.00089007
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97502104
55Viral myocarditis_Homo sapiens_hsa054160.97142689
56Legionellosis_Homo sapiens_hsa051340.96925415
57Dorso-ventral axis formation_Homo sapiens_hsa043200.96638090
58ABC transporters_Homo sapiens_hsa020100.95812669
59Platelet activation_Homo sapiens_hsa046110.92627195
60Pancreatic cancer_Homo sapiens_hsa052120.92575645
61Toxoplasmosis_Homo sapiens_hsa051450.91831848
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91606509
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90388747
64Colorectal cancer_Homo sapiens_hsa052100.89548591
65TNF signaling pathway_Homo sapiens_hsa046680.88912471
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84827957
67Malaria_Homo sapiens_hsa051440.83353454
68HIF-1 signaling pathway_Homo sapiens_hsa040660.82973611
69Prolactin signaling pathway_Homo sapiens_hsa049170.82383073
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.80701303
71Shigellosis_Homo sapiens_hsa051310.80206952
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.80162214
73Tuberculosis_Homo sapiens_hsa051520.79431525
74Type II diabetes mellitus_Homo sapiens_hsa049300.79152840
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79098986
76Hepatitis C_Homo sapiens_hsa051600.78576092
77Oocyte meiosis_Homo sapiens_hsa041140.78498293
78Pathways in cancer_Homo sapiens_hsa052000.77673302
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77405239
80Prostate cancer_Homo sapiens_hsa052150.77300171
81Hippo signaling pathway_Homo sapiens_hsa043900.76363515
82N-Glycan biosynthesis_Homo sapiens_hsa005100.74862815
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74756734
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.74601964
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74016691
86TGF-beta signaling pathway_Homo sapiens_hsa043500.73297555
87Acute myeloid leukemia_Homo sapiens_hsa052210.72521466
88Focal adhesion_Homo sapiens_hsa045100.72072100
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71413525
90Basal transcription factors_Homo sapiens_hsa030220.70443828
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.69497379
92FoxO signaling pathway_Homo sapiens_hsa040680.69495040
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67723419
94Chemokine signaling pathway_Homo sapiens_hsa040620.65882463
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65650534
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.64297864
97Bladder cancer_Homo sapiens_hsa052190.64284162
98Butanoate metabolism_Homo sapiens_hsa006500.64078014
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63495350
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63376945
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61140471
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60264725
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.59269707
104Rheumatoid arthritis_Homo sapiens_hsa053230.57900620
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57364057
106Endometrial cancer_Homo sapiens_hsa052130.56908297
107Hematopoietic cell lineage_Homo sapiens_hsa046400.55277659
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54787293
109Inositol phosphate metabolism_Homo sapiens_hsa005620.54300453
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52787627
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52760597
112Allograft rejection_Homo sapiens_hsa053300.51979534
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51893937
114T cell receptor signaling pathway_Homo sapiens_hsa046600.51506666
115Staphylococcus aureus infection_Homo sapiens_hsa051500.51337456
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51134997
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50033235
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49861446
119Basal cell carcinoma_Homo sapiens_hsa052170.49488885
120Non-small cell lung cancer_Homo sapiens_hsa052230.49203186
121AMPK signaling pathway_Homo sapiens_hsa041520.48981469
122ECM-receptor interaction_Homo sapiens_hsa045120.48143670
123Insulin resistance_Homo sapiens_hsa049310.47625928
124Sphingolipid metabolism_Homo sapiens_hsa006000.46990021
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46568513
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.44703462
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.44595680
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42373690
129Olfactory transduction_Homo sapiens_hsa047400.41374242
130African trypanosomiasis_Homo sapiens_hsa051430.37831725
131Renal cell carcinoma_Homo sapiens_hsa052110.37380087
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34773631
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33727595
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33208551
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31468388
136Phagosome_Homo sapiens_hsa041450.29509642
137MAPK signaling pathway_Homo sapiens_hsa040100.29056719
138Tryptophan metabolism_Homo sapiens_hsa003800.28275868

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