ZFHX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.91525697
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.26811721
3pyrimidine nucleobase catabolic process (GO:0006208)5.17856382
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13967352
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88568659
6vocalization behavior (GO:0071625)4.74942721
7locomotory exploration behavior (GO:0035641)4.65100431
8synaptic vesicle maturation (GO:0016188)4.59505652
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52362036
10cerebellar Purkinje cell differentiation (GO:0021702)4.47102433
11response to pheromone (GO:0019236)4.39274925
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.29369742
13neuron cell-cell adhesion (GO:0007158)4.26147127
14synaptic vesicle exocytosis (GO:0016079)4.22251194
15nucleobase catabolic process (GO:0046113)4.19311898
16regulation of synaptic vesicle exocytosis (GO:2000300)4.16376736
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.16161527
18dendritic spine morphogenesis (GO:0060997)4.11033299
19regulation of glutamate receptor signaling pathway (GO:1900449)4.05601345
20layer formation in cerebral cortex (GO:0021819)4.00542045
21cell proliferation in forebrain (GO:0021846)3.95882877
22synaptic transmission, glutamatergic (GO:0035249)3.95566276
23establishment of mitochondrion localization (GO:0051654)3.94998279
24axonemal dynein complex assembly (GO:0070286)3.84396050
25glutamate receptor signaling pathway (GO:0007215)3.83911204
26protein localization to synapse (GO:0035418)3.83234729
27cerebellar granule cell differentiation (GO:0021707)3.78634781
28neurotransmitter secretion (GO:0007269)3.78402773
29neuronal action potential propagation (GO:0019227)3.77996250
30auditory behavior (GO:0031223)3.76264570
31regulation of synaptic vesicle transport (GO:1902803)3.72260598
32cell differentiation in hindbrain (GO:0021533)3.71475922
33neuron recognition (GO:0008038)3.63600781
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63292910
35glutamate secretion (GO:0014047)3.62288592
36cell migration in hindbrain (GO:0021535)3.60098201
37cilium movement (GO:0003341)3.60020233
38neuron-neuron synaptic transmission (GO:0007270)3.57440185
39epithelial cilium movement (GO:0003351)3.56957210
40regulation of neuronal synaptic plasticity (GO:0048168)3.56562481
41axonal fasciculation (GO:0007413)3.55018256
42gamma-aminobutyric acid transport (GO:0015812)3.55013309
43transmission of nerve impulse (GO:0019226)3.53419053
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53135791
45synaptic vesicle endocytosis (GO:0048488)3.50199837
46mitochondrion transport along microtubule (GO:0047497)3.49194169
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.49194169
48retinal ganglion cell axon guidance (GO:0031290)3.48953525
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.45838276
50positive regulation of membrane potential (GO:0045838)3.45365144
51regulation of cilium movement (GO:0003352)3.44819937
52positive regulation of synapse maturation (GO:0090129)3.43220363
53protein polyglutamylation (GO:0018095)3.40815158
54long-term memory (GO:0007616)3.40356178
55dendrite morphogenesis (GO:0048813)3.39875824
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39571294
57nonmotile primary cilium assembly (GO:0035058)3.38508361
58neuronal ion channel clustering (GO:0045161)3.37397303
59axon extension (GO:0048675)3.35206830
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.34695666
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34694408
62exploration behavior (GO:0035640)3.34669554
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33794789
64regulation of synapse structural plasticity (GO:0051823)3.33192791
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31957953
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30407189
67membrane hyperpolarization (GO:0060081)3.27274208
68presynaptic membrane organization (GO:0097090)3.26775431
69membrane depolarization during action potential (GO:0086010)3.26465753
70neuromuscular process controlling posture (GO:0050884)3.25580645
71regulation of postsynaptic membrane potential (GO:0060078)3.24477888
72chemosensory behavior (GO:0007635)3.23208426
73mechanosensory behavior (GO:0007638)3.22501185
74postsynaptic membrane organization (GO:0001941)3.22106837
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21275153
76innervation (GO:0060384)3.20589368
77prepulse inhibition (GO:0060134)3.20263394
78neuron projection extension involved in neuron projection guidance (GO:1902284)3.19626171
79axon extension involved in axon guidance (GO:0048846)3.19626171
80ganglion development (GO:0061548)3.15151935
81cellular potassium ion homeostasis (GO:0030007)3.14703178
82spinal cord development (GO:0021510)3.14486384
83neurotransmitter-gated ion channel clustering (GO:0072578)3.14211298
84presynaptic membrane assembly (GO:0097105)3.12918962
85negative regulation of axon guidance (GO:1902668)3.11804639
86response to auditory stimulus (GO:0010996)3.11595176
87neurotransmitter transport (GO:0006836)3.11000876
88central nervous system projection neuron axonogenesis (GO:0021952)3.09978197
89regulation of respiratory system process (GO:0044065)3.08907499
90synaptic transmission, cholinergic (GO:0007271)3.08107910
91cerebral cortex radially oriented cell migration (GO:0021799)3.08031735
92neuromuscular process controlling balance (GO:0050885)3.07457921
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04036345
94regulation of axon guidance (GO:1902667)3.02808008
95regulation of neurotransmitter secretion (GO:0046928)3.01472154
96regulation of microtubule-based movement (GO:0060632)3.00963333
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.00688982
98cilium or flagellum-dependent cell motility (GO:0001539)3.00600197
99substrate-independent telencephalic tangential migration (GO:0021826)3.00541491
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.00541491
101regulation of dendritic spine morphogenesis (GO:0061001)3.00430572
102positive regulation of dendritic spine development (GO:0060999)3.00401484
103adult walking behavior (GO:0007628)3.00133572
104membrane depolarization (GO:0051899)2.97746110
105cranial nerve morphogenesis (GO:0021602)2.97132932
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97010977
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96009803
108regulation of respiratory gaseous exchange (GO:0043576)2.95503248
109dendrite development (GO:0016358)2.94718857
110axoneme assembly (GO:0035082)2.94572250
111sodium ion export (GO:0071436)2.94271980
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93742043
113synapse assembly (GO:0007416)2.93208616
114dendritic spine organization (GO:0097061)2.91462268
115camera-type eye morphogenesis (GO:0048593)2.91048198
116cell communication by electrical coupling (GO:0010644)2.90303886
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.89056799
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86544820
119regulation of ARF protein signal transduction (GO:0032012)2.85758867
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.85736758
121neuromuscular synaptic transmission (GO:0007274)2.84939156
122negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83537489
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.83537489
124regulation of translation, ncRNA-mediated (GO:0045974)2.83537489
125neuron projection extension (GO:1990138)2.82516612
126cerebellar Purkinje cell layer development (GO:0021680)2.82419347
127regulation of synapse maturation (GO:0090128)2.82309162
128regulation of vesicle fusion (GO:0031338)2.81665708
129regulation of action potential (GO:0098900)2.81392965
130glycine transport (GO:0015816)2.80895163
131regulation of axon extension involved in axon guidance (GO:0048841)2.80217420
132spinal cord motor neuron differentiation (GO:0021522)2.80199984
133microtubule bundle formation (GO:0001578)2.79718813
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79597023
135regulation of neurotransmitter levels (GO:0001505)2.79025189
136positive regulation of synapse assembly (GO:0051965)2.78070863
137regulation of synaptic plasticity (GO:0048167)2.77701449
138neurofilament cytoskeleton organization (GO:0060052)2.77390404
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.76152911
140regulation of neurotransmitter transport (GO:0051588)2.74889270
141cerebellum development (GO:0021549)2.74651698
142striatum development (GO:0021756)2.71418895
143somite development (GO:0061053)2.67261535
144forebrain neuron differentiation (GO:0021879)2.66727113
145positive regulation of gastrulation (GO:2000543)2.66160818
146otic vesicle formation (GO:0030916)2.65803228
147cell differentiation in spinal cord (GO:0021515)2.63082580
148central nervous system myelination (GO:0022010)2.62487212
149axon ensheathment in central nervous system (GO:0032291)2.62487212
150positive regulation of action potential (GO:0045760)2.61140159
151olfactory bulb development (GO:0021772)2.60689731
152cerebral cortex neuron differentiation (GO:0021895)2.60581292
153regulation of posttranscriptional gene silencing (GO:0060147)2.60315500
154regulation of gene silencing by miRNA (GO:0060964)2.60315500
155regulation of gene silencing by RNA (GO:0060966)2.60315500
156genetic imprinting (GO:0071514)2.59738254
157telencephalon development (GO:0021537)2.59686036
158intraciliary transport (GO:0042073)2.58109736
159cilium assembly (GO:0042384)2.55420311
160establishment or maintenance of monopolar cell polarity (GO:0061339)2.54785920
161establishment of monopolar cell polarity (GO:0061162)2.54785920
162cilium organization (GO:0044782)2.54027886
163hippocampus development (GO:0021766)2.53133342
164neuron fate determination (GO:0048664)2.52485344
165hindbrain development (GO:0030902)2.52136082
166calcium ion-dependent exocytosis (GO:0017156)2.51569936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57817957
2GBX2_23144817_ChIP-Seq_PC3_Human3.21055962
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12141593
4REST_21632747_ChIP-Seq_MESCs_Mouse2.83450711
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76933021
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74772774
7DROSHA_22980978_ChIP-Seq_HELA_Human2.70227649
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69492227
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63215025
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.51369423
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.50756105
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47819520
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47819520
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47732098
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41845703
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32027286
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.31891727
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31359812
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30724783
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29805460
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24098763
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23679598
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22953328
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.21838061
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19598607
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19553178
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16981831
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.10057630
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08773034
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87584436
31VDR_22108803_ChIP-Seq_LS180_Human1.78712890
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71710033
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69152861
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59943192
35* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57512924
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53292591
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.53197271
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50338643
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44825924
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.44338499
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.43853748
42SMAD4_21799915_ChIP-Seq_A2780_Human1.43226253
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42813327
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.40713746
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.39965292
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37540344
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37257177
48AR_21572438_ChIP-Seq_LNCaP_Human1.36487750
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35439546
50KDM2B_26808549_Chip-Seq_K562_Human1.35269765
51RNF2_27304074_Chip-Seq_NSC_Mouse1.34234721
52* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33948563
53IGF1R_20145208_ChIP-Seq_DFB_Human1.32240801
54* AR_19668381_ChIP-Seq_PC3_Human1.32136109
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30682067
56STAT3_23295773_ChIP-Seq_U87_Human1.29403513
57ZNF274_21170338_ChIP-Seq_K562_Hela1.26500754
58* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26398367
59FUS_26573619_Chip-Seq_HEK293_Human1.24808858
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22264676
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22120405
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22048541
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.20722371
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20498341
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20164310
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17797386
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16283614
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16262689
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15891827
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15146732
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15118600
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.14540062
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14324130
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13992901
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11967035
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.09696488
77TCF4_23295773_ChIP-Seq_U87_Human1.08514852
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08086782
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07457374
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06900808
81TAF15_26573619_Chip-Seq_HEK293_Human1.06593167
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06468888
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06068090
84P300_19829295_ChIP-Seq_ESCs_Human1.06033835
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04549054
86AHR_22903824_ChIP-Seq_MCF-7_Human1.04422862
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.04242767
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02399622
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01762881
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01615689
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01002423
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00788789
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.00230093
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00018219
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99785662
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98759701
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98304152
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98304152
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98198052
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.98175650
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97354452
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.97160497
103* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96991499
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.96782742
105RUNX2_22187159_ChIP-Seq_PCA_Human0.96586421
106CTCF_27219007_Chip-Seq_Bcells_Human0.95152799
107AR_25329375_ChIP-Seq_VCAP_Human0.94825187
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94523803
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92967055
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91402304
111IRF1_19129219_ChIP-ChIP_H3396_Human0.90411510
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90318454
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89464876
114CBP_20019798_ChIP-Seq_JUKART_Human0.89464876
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89367581
116WDR5_24793694_ChIP-Seq_LNCAP_Human0.88143943
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88022653
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87265904
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.87009836
120* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86986471
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86199325
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84974073
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84541312
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84511864
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84242902
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.83862701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.94266244
2MP0003880_abnormal_central_pattern3.60103165
3MP0003635_abnormal_synaptic_transmissio3.43844534
4MP0004270_analgesia3.35353840
5MP0005423_abnormal_somatic_nervous2.96504791
6MP0009046_muscle_twitch2.89331186
7MP0002063_abnormal_learning/memory/cond2.75531153
8MP0009745_abnormal_behavioral_response2.74149984
9MP0002064_seizures2.60100863
10MP0002572_abnormal_emotion/affect_behav2.46245689
11MP0000566_synostosis2.45742797
12MP0001486_abnormal_startle_reflex2.41537637
13MP0003136_yellow_coat_color2.39459700
14MP0002272_abnormal_nervous_system2.38323799
15MP0003123_paternal_imprinting2.36514971
16MP0002734_abnormal_mechanical_nocicepti2.34534265
17MP0002822_catalepsy2.27231780
18MP0005646_abnormal_pituitary_gland2.21909809
19MP0000778_abnormal_nervous_system2.15985904
20MP0008877_abnormal_DNA_methylation2.14382468
21MP0003787_abnormal_imprinting2.12800977
22MP0003122_maternal_imprinting2.12778504
23MP0001968_abnormal_touch/_nociception2.11039897
24MP0002184_abnormal_innervation2.07114719
25MP0002909_abnormal_adrenal_gland2.00724986
26MP0005645_abnormal_hypothalamus_physiol2.00406983
27MP0008569_lethality_at_weaning1.92304788
28MP0006292_abnormal_olfactory_placode1.91944138
29MP0009379_abnormal_foot_pigmentation1.90440706
30MP0002733_abnormal_thermal_nociception1.88713906
31MP0002067_abnormal_sensory_capabilities1.86985807
32MP0002557_abnormal_social/conspecific_i1.85348833
33MP0000955_abnormal_spinal_cord1.81719546
34MP0002638_abnormal_pupillary_reflex1.78347156
35MP0001501_abnormal_sleep_pattern1.77908469
36MP0003283_abnormal_digestive_organ1.77517658
37MP0001984_abnormal_olfaction1.75102045
38MP0001970_abnormal_pain_threshold1.71813654
39MP0006276_abnormal_autonomic_nervous1.70980497
40MP0001502_abnormal_circadian_rhythm1.67783782
41MP0004811_abnormal_neuron_physiology1.65925242
42MP0002735_abnormal_chemical_nociception1.63328079
43MP0001529_abnormal_vocalization1.62727866
44MP0001440_abnormal_grooming_behavior1.62152593
45MP0005394_taste/olfaction_phenotype1.56479707
46MP0005499_abnormal_olfactory_system1.56479707
47MP0002938_white_spotting1.55870010
48MP0001188_hyperpigmentation1.55350677
49MP0006072_abnormal_retinal_apoptosis1.55139594
50MP0002882_abnormal_neuron_morphology1.54730038
51MP0005386_behavior/neurological_phenoty1.54205506
52MP0004924_abnormal_behavior1.54205506
53MP0004858_abnormal_nervous_system1.52832809
54MP0009780_abnormal_chondrocyte_physiolo1.49095707
55MP0000631_abnormal_neuroendocrine_gland1.44816252
56MP0004145_abnormal_muscle_electrophysio1.44177900
57MP0008961_abnormal_basal_metabolism1.43086674
58MP0004142_abnormal_muscle_tone1.40942913
59MP0004885_abnormal_endolymph1.39522504
60MP0000049_abnormal_middle_ear1.38315524
61MP0002736_abnormal_nociception_after1.37558020
62MP0002066_abnormal_motor_capabilities/c1.32521146
63MP0001293_anophthalmia1.32073959
64MP0003878_abnormal_ear_physiology1.31398735
65MP0005377_hearing/vestibular/ear_phenot1.31398735
66MP0002152_abnormal_brain_morphology1.29180089
67MP0005551_abnormal_eye_electrophysiolog1.27938689
68MP0002653_abnormal_ependyma_morphology1.23601954
69MP0003121_genomic_imprinting1.21929350
70MP0010386_abnormal_urinary_bladder1.20272422
71MP0000026_abnormal_inner_ear1.19382862
72MP0004742_abnormal_vestibular_system1.15866995
73MP0003942_abnormal_urinary_system1.15831124
74MP0004043_abnormal_pH_regulation1.13625958
75MP0010030_abnormal_orbit_morphology1.13582818
76MP0003938_abnormal_ear_development1.05492448
77MP0003937_abnormal_limbs/digits/tail_de1.05425598
78MP0003879_abnormal_hair_cell1.05020103
79MP0002069_abnormal_eating/drinking_beha1.04936991
80MP0002229_neurodegeneration1.04528505
81MP0002234_abnormal_pharynx_morphology1.04483934
82MP0000569_abnormal_digit_pigmentation1.03905408
83MP0003890_abnormal_embryonic-extraembry1.00412555
84MP0005409_darkened_coat_color1.00218565
85MP0008789_abnormal_olfactory_epithelium0.99488160
86MP0002752_abnormal_somatic_nervous0.99177876
87MP0003861_abnormal_nervous_system0.98224609
88MP0003633_abnormal_nervous_system0.97974876
89MP0003137_abnormal_impulse_conducting0.97128628
90MP0002163_abnormal_gland_morphology0.95719905
91MP0005195_abnormal_posterior_eye0.93925374
92MP0003172_abnormal_lysosome_physiology0.93172147
93MP0005253_abnormal_eye_physiology0.92083591
94MP0001944_abnormal_pancreas_morphology0.89189187
95MP0002751_abnormal_autonomic_nervous0.88892986
96MP0003119_abnormal_digestive_system0.88828099
97MP0002693_abnormal_pancreas_physiology0.86830128
98MP0003631_nervous_system_phenotype0.86569652
99MP0001286_abnormal_eye_development0.85604645
100MP0005379_endocrine/exocrine_gland_phen0.85264971
101MP0000534_abnormal_ureter_morphology0.85131783
102MP0001485_abnormal_pinna_reflex0.84069209
103MP0003646_muscle_fatigue0.83642048
104MP0003632_abnormal_nervous_system0.82667365
105MP0000678_abnormal_parathyroid_gland0.81962877
106MP0003183_abnormal_peptide_metabolism0.81493765
107MP0003634_abnormal_glial_cell0.80381812
108MP0003567_abnormal_fetal_cardiomyocyte0.79771776
109MP0003329_amyloid_beta_deposits0.79295503
110MP0002249_abnormal_larynx_morphology0.78227783
111MP0001905_abnormal_dopamine_level0.77766816
112MP0004085_abnormal_heartbeat0.77624558
113MP0001963_abnormal_hearing_physiology0.74391121
114MP0002116_abnormal_craniofacial_bone0.74319498
115MP0001299_abnormal_eye_distance/0.74278238
116MP0004133_heterotaxia0.73836974
117MP0003698_abnormal_male_reproductive0.73700768
118MP0003011_delayed_dark_adaptation0.73659846
119MP0005084_abnormal_gallbladder_morpholo0.73494501
120MP0009053_abnormal_anal_canal0.72057250
121MP0002697_abnormal_eye_size0.71461203
122MP0002081_perinatal_lethality0.71014657
123MP0003755_abnormal_palate_morphology0.69941493
124MP0010769_abnormal_survival0.69540862
125MP0010770_preweaning_lethality0.69178752
126MP0002082_postnatal_lethality0.69178752
127MP0002102_abnormal_ear_morphology0.69130200
128MP0005410_abnormal_fertilization0.68872750
129MP0010768_mortality/aging0.67180335
130MP0003045_fibrosis0.66762619
131MP0001943_abnormal_respiration0.66649210
132MP0005535_abnormal_body_temperature0.64455053

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.05833221
2Myokymia (HP:0002411)4.50110331
3Focal seizures (HP:0007359)4.43426571
4Visual hallucinations (HP:0002367)4.11521967
5Progressive cerebellar ataxia (HP:0002073)4.11513618
6Febrile seizures (HP:0002373)4.05999441
7Abnormal ciliary motility (HP:0012262)3.79357785
8Abnormality of midbrain morphology (HP:0002418)3.78603725
9Molar tooth sign on MRI (HP:0002419)3.78603725
10Nephronophthisis (HP:0000090)3.78165489
11Epileptic encephalopathy (HP:0200134)3.73735850
12Pancreatic fibrosis (HP:0100732)3.70006877
13Action tremor (HP:0002345)3.49943120
14Abnormal respiratory motile cilium physiology (HP:0012261)3.47322972
15True hermaphroditism (HP:0010459)3.41831038
16Hepatoblastoma (HP:0002884)3.33634439
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.33355345
18Absent/shortened dynein arms (HP:0200106)3.33355345
19Abnormal respiratory epithelium morphology (HP:0012253)3.20613686
20Abnormal respiratory motile cilium morphology (HP:0005938)3.20613686
21Atonic seizures (HP:0010819)3.14030851
22Pancreatic cysts (HP:0001737)3.12490787
23Broad-based gait (HP:0002136)3.09707674
24Genetic anticipation (HP:0003743)3.09089495
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04355889
26Chronic hepatic failure (HP:0100626)3.01345730
27Gaze-evoked nystagmus (HP:0000640)3.00592330
28Absence seizures (HP:0002121)2.99940500
29Supranuclear gaze palsy (HP:0000605)2.91628032
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91264204
31Hemiparesis (HP:0001269)2.89907111
32Abnormality of the renal medulla (HP:0100957)2.85166550
33Dialeptic seizures (HP:0011146)2.83999511
34Gait imbalance (HP:0002141)2.73692764
35Anencephaly (HP:0002323)2.70416186
36Poor eye contact (HP:0000817)2.69195055
37Agitation (HP:0000713)2.67001363
38Septo-optic dysplasia (HP:0100842)2.64703835
39Neoplasm of the heart (HP:0100544)2.63023306
40Drooling (HP:0002307)2.60913686
41Excessive salivation (HP:0003781)2.60913686
42Impaired social interactions (HP:0000735)2.60131746
43Abnormal social behavior (HP:0012433)2.60131746
44Impaired smooth pursuit (HP:0007772)2.59865652
45Dysmetria (HP:0001310)2.59858871
46Cystic liver disease (HP:0006706)2.58890247
47Generalized tonic-clonic seizures (HP:0002069)2.58067971
48EEG with generalized epileptiform discharges (HP:0011198)2.56414570
49Amblyopia (HP:0000646)2.55470776
50Epileptiform EEG discharges (HP:0011182)2.55411359
51Dysdiadochokinesis (HP:0002075)2.53503448
52Sleep apnea (HP:0010535)2.49577403
53Depression (HP:0000716)2.47601178
54Hypsarrhythmia (HP:0002521)2.44542532
55Sclerocornea (HP:0000647)2.44280902
56Medial flaring of the eyebrow (HP:0010747)2.43409180
57Ankle clonus (HP:0011448)2.42479154
58Spastic gait (HP:0002064)2.39441828
59Truncal ataxia (HP:0002078)2.36897278
60Hyperventilation (HP:0002883)2.35085083
61Abnormality of ocular smooth pursuit (HP:0000617)2.33300993
62Genital tract atresia (HP:0001827)2.33162201
63Impaired vibration sensation in the lower limbs (HP:0002166)2.33067751
64Vaginal atresia (HP:0000148)2.32523345
65Papilledema (HP:0001085)2.32200120
66Failure to thrive in infancy (HP:0001531)2.32183164
67Severe visual impairment (HP:0001141)2.32070748
68Rib fusion (HP:0000902)2.28932030
69Abnormality of the aortic arch (HP:0012303)2.28716981
70Absent speech (HP:0001344)2.28607045
71Abnormality of the corticospinal tract (HP:0002492)2.27119279
72Urinary bladder sphincter dysfunction (HP:0002839)2.26851210
73Congenital primary aphakia (HP:0007707)2.25397666
74Rhinitis (HP:0012384)2.22239601
75Anxiety (HP:0000739)2.21070930
76Abnormal eating behavior (HP:0100738)2.20794380
77Postaxial foot polydactyly (HP:0001830)2.18638390
78Nephrogenic diabetes insipidus (HP:0009806)2.17506005
79Scanning speech (HP:0002168)2.17105269
80Limb dystonia (HP:0002451)2.17052730
81Intention tremor (HP:0002080)2.15864486
82Hemiplegia (HP:0002301)2.14391692
83Insomnia (HP:0100785)2.11395681
84Protruding tongue (HP:0010808)2.10838731
85Narrow forehead (HP:0000341)2.10067607
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.08226285
87Anophthalmia (HP:0000528)2.04127733
88Abnormality of calcium-phosphate metabolism (HP:0100530)2.04041273
89Preaxial hand polydactyly (HP:0001177)2.03450363
90Macroorchidism (HP:0000053)2.02085083
91Hyperinsulinemic hypoglycemia (HP:0000825)2.01945518
92Growth hormone deficiency (HP:0000824)2.01777160
93Pointed chin (HP:0000307)2.01767551
94Optic nerve hypoplasia (HP:0000609)2.01407117
95Pachygyria (HP:0001302)2.00665720
96Postural instability (HP:0002172)2.00252865
97Chronic bronchitis (HP:0004469)2.00245828
98Abnormal number of incisors (HP:0011064)1.99861518
99Pendular nystagmus (HP:0012043)1.99527963
100Tubular atrophy (HP:0000092)1.96892416
101Poor coordination (HP:0002370)1.95572525
102Open mouth (HP:0000194)1.95008886
103Stereotypic behavior (HP:0000733)1.94033299
104Postural tremor (HP:0002174)1.93171358
105Diplopia (HP:0000651)1.92760765
106Abnormality of binocular vision (HP:0011514)1.92760765
107Congenital hepatic fibrosis (HP:0002612)1.90913461
108Abnormality of the lower motor neuron (HP:0002366)1.89811079
109Urinary urgency (HP:0000012)1.89489559
110Abnormal rod and cone electroretinograms (HP:0008323)1.88795282
111Lissencephaly (HP:0001339)1.88704655
112Abnormality of the labia minora (HP:0012880)1.88079874
113Postaxial hand polydactyly (HP:0001162)1.86567496
114Holoprosencephaly (HP:0001360)1.85702533
115Occipital encephalocele (HP:0002085)1.85312484
116Absent septum pellucidum (HP:0001331)1.84736061
117Dandy-Walker malformation (HP:0001305)1.83621868
118Decreased circulating renin level (HP:0003351)1.83612262
119Reticulocytopenia (HP:0001896)1.82630315
120Obsessive-compulsive behavior (HP:0000722)1.82524263
121Tented upper lip vermilion (HP:0010804)1.82387745
122Diastasis recti (HP:0001540)1.82177037
123Mask-like facies (HP:0000298)1.82075852
124Gastroesophageal reflux (HP:0002020)1.81977644
125Maternal diabetes (HP:0009800)1.81755347
126Hip dysplasia (HP:0001385)1.81658628
127Megalencephaly (HP:0001355)1.81288338
128Bony spicule pigmentary retinopathy (HP:0007737)1.80917296
129Lower limb muscle weakness (HP:0007340)1.80789735
130Congenital stationary night blindness (HP:0007642)1.80035781
131Anteriorly placed anus (HP:0001545)1.79628173
132Specific learning disability (HP:0001328)1.79489064
133Abnormal pancreas size (HP:0012094)1.77897396
134Elfin facies (HP:0004428)1.76700601
135Autism (HP:0000717)1.76252852
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76243383
137Optic nerve coloboma (HP:0000588)1.75559517
138Abnormality of the astrocytes (HP:0100707)1.75208360
139Astrocytoma (HP:0009592)1.75208360
140Osteomalacia (HP:0002749)1.74969613
141Exotropia (HP:0000577)1.74532888
142Prolonged QT interval (HP:0001657)1.74504537
143Scrotal hypoplasia (HP:0000046)1.74231282
144Poor suck (HP:0002033)1.74192432
145Esotropia (HP:0000565)1.74142392
146Hypoglycemic seizures (HP:0002173)1.72767287
147Abnormality of macular pigmentation (HP:0008002)1.72685771
148Abnormal EKG (HP:0003115)1.72569756
149Micropenis (HP:0000054)1.72554819
150Male pseudohermaphroditism (HP:0000037)1.72401255
151Oligodactyly (hands) (HP:0001180)1.72379331
152Symptomatic seizures (HP:0011145)1.71216441
153Labial hypoplasia (HP:0000066)1.70683602
154Split foot (HP:0001839)1.70486570
155Adrenal hypoplasia (HP:0000835)1.69407222
156Widely spaced teeth (HP:0000687)1.67921078
157Supernumerary spleens (HP:0009799)1.67264645
158Progressive inability to walk (HP:0002505)1.66765687
159Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66623087
160Short 4th metacarpal (HP:0010044)1.66623087
161Psychosis (HP:0000709)1.66025345
162Impulsivity (HP:0100710)1.65542007
163Pheochromocytoma (HP:0002666)1.65250923
164Hypoplastic nipples (HP:0002557)1.64238345
165Hyperacusis (HP:0010780)1.63572176
166Neoplasm of the adrenal cortex (HP:0100641)1.62820669
167Bradykinesia (HP:0002067)1.61703081
168Status epilepticus (HP:0002133)1.61663502
169Partial duplication of thumb phalanx (HP:0009944)1.60912819
170Bifid tongue (HP:0010297)1.60757397
171Neoplasm of the oral cavity (HP:0100649)1.60735733
172Abnormal hair whorl (HP:0010721)1.60447212
173Spinal canal stenosis (HP:0003416)1.60168983
174Intestinal atresia (HP:0011100)1.59952329
175Gait ataxia (HP:0002066)1.58394699
176Polyphagia (HP:0002591)1.57867085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.50225488
2NTRK34.27355706
3MARK13.01056776
4EPHA42.92910394
5INSRR2.76751210
6MAP3K92.76548804
7MAP3K42.57896690
8NTRK22.26251342
9UHMK12.16395713
10TNIK2.15585950
11PAK62.15113812
12MINK11.89612274
13MAP2K71.86945420
14ICK1.86056884
15PRKD31.82424763
16SIK21.80803029
17DAPK21.77475479
18WNK41.67061154
19PRPF4B1.64001843
20SIK31.62354071
21MAPK131.56233750
22BRD41.54986888
23CASK1.53580378
24CAMK1G1.52169124
25KSR11.51928881
26PNCK1.48337046
27FGFR21.48087146
28MARK21.45355674
29TYRO31.42888020
30NTRK11.42292964
31CDK51.35238358
32NUAK11.31779894
33CDC71.29433041
34EPHB21.28468577
35DYRK31.25908264
36MAP2K41.24984646
37HIPK21.24880958
38SGK2231.23594178
39SGK4941.23594178
40BMPR1B1.23556201
41WNK11.22948723
42CAMKK11.21550950
43CAMKK21.21317046
44TLK11.20600846
45STK381.17843044
46SGK21.17437106
47CDC42BPA1.16570258
48MAP4K21.16384852
49CDK121.09467387
50RIPK11.08768451
51ADRBK21.08355317
52MKNK21.05593761
53GRK11.02197457
54DYRK1A1.01405073
55DMPK1.01198943
56WNK31.00305716
57GRK50.99601643
58NEK20.99584522
59SGK30.97280768
60MAPK150.96089997
61IRAK20.94192951
62MAP3K20.93295618
63BCR0.93113727
64PHKG10.91768643
65PHKG20.91768643
66FRK0.91662445
67KSR20.91647240
68PRKCH0.89182152
69PRKCG0.88855678
70AKT30.88270642
71FES0.85841033
72PRKD20.85456493
73STK110.81927364
74PAK30.81512926
75CAMK10.80516231
76CAMK40.79834241
77NEK60.78468349
78CAMK1D0.77897226
79CAMK2B0.76526357
80SGK10.75986723
81PLK40.75335649
82CAMK2A0.73703347
83MAP3K130.71716239
84ALK0.71525614
85DYRK1B0.69028038
86DAPK10.68763609
87MAPK100.68260162
88RIPK40.68207769
89PLK20.64302936
90CDK180.63185695
91TAOK10.62222353
92RPS6KA30.60333747
93ERBB20.59508618
94RET0.59255598
95CDK150.57181440
96CDK30.56375955
97CSNK1G20.55425131
98CDK190.55411134
99PDGFRA0.55088227
100PRKACA0.54597537
101PINK10.54573577
102BRAF0.54217483
103MAP3K70.52632684
104CDK140.52566743
105ADRBK10.52381638
106CAMK2D0.52149388
107GSK3B0.52058559
108DYRK20.50331286
109PRKCZ0.50104824
110NME10.49951397
111ZAK0.49878336
112MAP3K10.49611276
113CDK11A0.49408289
114OXSR10.48540513
115CSNK1A10.47904312
116EPHA30.47534557
117TIE10.46915558
118RPS6KA60.46653954
119PASK0.46340647
120PRKCQ0.45731676
121PRKCE0.44999434
122PRKDC0.44727336
123RPS6KA20.44688381
124TAF10.44371568
125PRKAA10.43233246
126PRKG10.43216723
127PKN10.42695527
128MKNK10.42627580
129MAPK80.42481346
130MAPK90.42312516
131TNK20.42249858
132CSNK1D0.41747480
133FYN0.40797851
134CSNK1E0.40271741
135AKT10.39907493
136MAPK140.38100610
137CSNK1G30.36808071
138STK390.36207118

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.61808511
2GABAergic synapse_Homo sapiens_hsa047272.74092354
3Insulin secretion_Homo sapiens_hsa049112.64009848
4Synaptic vesicle cycle_Homo sapiens_hsa047212.62664028
5Glutamatergic synapse_Homo sapiens_hsa047242.61465128
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56413089
7Circadian entrainment_Homo sapiens_hsa047132.55012852
8Morphine addiction_Homo sapiens_hsa050322.50585567
9Long-term potentiation_Homo sapiens_hsa047202.32914549
10Amphetamine addiction_Homo sapiens_hsa050312.30881343
11Oxidative phosphorylation_Homo sapiens_hsa001902.22981719
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20783138
13Olfactory transduction_Homo sapiens_hsa047402.16446576
14Taste transduction_Homo sapiens_hsa047422.14328861
15Dopaminergic synapse_Homo sapiens_hsa047282.09816705
16Cocaine addiction_Homo sapiens_hsa050302.07266604
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02642821
18Parkinsons disease_Homo sapiens_hsa050122.02002904
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.99047683
20Type II diabetes mellitus_Homo sapiens_hsa049301.93239011
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90972704
22Cholinergic synapse_Homo sapiens_hsa047251.89987950
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89764129
24Huntingtons disease_Homo sapiens_hsa050161.87828443
25Serotonergic synapse_Homo sapiens_hsa047261.82582682
26Salivary secretion_Homo sapiens_hsa049701.80236600
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79531244
28Ribosome_Homo sapiens_hsa030101.73361843
29Long-term depression_Homo sapiens_hsa047301.70165985
30Steroid biosynthesis_Homo sapiens_hsa001001.66719770
31Alzheimers disease_Homo sapiens_hsa050101.56235441
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52445829
33Gastric acid secretion_Homo sapiens_hsa049711.45825559
34Calcium signaling pathway_Homo sapiens_hsa040201.42475432
35Oxytocin signaling pathway_Homo sapiens_hsa049211.42124124
36Renin secretion_Homo sapiens_hsa049241.41854105
37Axon guidance_Homo sapiens_hsa043601.41163327
38Linoleic acid metabolism_Homo sapiens_hsa005911.40197277
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39732928
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35621423
41Gap junction_Homo sapiens_hsa045401.31134870
42Butanoate metabolism_Homo sapiens_hsa006501.31012603
43GnRH signaling pathway_Homo sapiens_hsa049121.29929320
44cAMP signaling pathway_Homo sapiens_hsa040241.28958080
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28294789
46RNA polymerase_Homo sapiens_hsa030201.27723067
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22639397
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19022029
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17469884
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16742376
51Circadian rhythm_Homo sapiens_hsa047101.14546592
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13211552
53ErbB signaling pathway_Homo sapiens_hsa040121.09898538
54Hippo signaling pathway_Homo sapiens_hsa043901.07596588
55Estrogen signaling pathway_Homo sapiens_hsa049151.04693000
56Pancreatic secretion_Homo sapiens_hsa049721.04220358
57Melanogenesis_Homo sapiens_hsa049161.03762872
58Basal transcription factors_Homo sapiens_hsa030221.02766264
59Tryptophan metabolism_Homo sapiens_hsa003801.00211185
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99790741
61Selenocompound metabolism_Homo sapiens_hsa004500.99456424
62Phototransduction_Homo sapiens_hsa047440.99436770
63Dorso-ventral axis formation_Homo sapiens_hsa043200.99041113
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95973417
65Protein export_Homo sapiens_hsa030600.94668802
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94480747
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.92799196
68Ether lipid metabolism_Homo sapiens_hsa005650.92060626
69Choline metabolism in cancer_Homo sapiens_hsa052310.90617610
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87901859
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87376601
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86270410
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.84842616
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83832293
75Type I diabetes mellitus_Homo sapiens_hsa049400.83635518
76Thyroid hormone synthesis_Homo sapiens_hsa049180.82276580
77Glioma_Homo sapiens_hsa052140.81703511
78MAPK signaling pathway_Homo sapiens_hsa040100.81050729
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78821523
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77987129
81Wnt signaling pathway_Homo sapiens_hsa043100.77505022
82Collecting duct acid secretion_Homo sapiens_hsa049660.77282579
83Inositol phosphate metabolism_Homo sapiens_hsa005620.77272724
84Alcoholism_Homo sapiens_hsa050340.77195583
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74081063
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72689940
87Cardiac muscle contraction_Homo sapiens_hsa042600.70954169
88Dilated cardiomyopathy_Homo sapiens_hsa054140.70417903
89mTOR signaling pathway_Homo sapiens_hsa041500.70092399
90Vibrio cholerae infection_Homo sapiens_hsa051100.69660836
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69531289
92Vitamin digestion and absorption_Homo sapiens_hsa049770.68816237
93Tight junction_Homo sapiens_hsa045300.68069600
94Fat digestion and absorption_Homo sapiens_hsa049750.67221078
95Fanconi anemia pathway_Homo sapiens_hsa034600.66663785
96Hedgehog signaling pathway_Homo sapiens_hsa043400.66529655
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66469040
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64925277
99beta-Alanine metabolism_Homo sapiens_hsa004100.64797631
100Retinol metabolism_Homo sapiens_hsa008300.64036476
101Glucagon signaling pathway_Homo sapiens_hsa049220.63519447
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63203754
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.61505819
104Endometrial cancer_Homo sapiens_hsa052130.58454280
105Ras signaling pathway_Homo sapiens_hsa040140.57737136
106Lysine degradation_Homo sapiens_hsa003100.57472801
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57411245
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57373826
109Renal cell carcinoma_Homo sapiens_hsa052110.55657489
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54011137
111Oocyte meiosis_Homo sapiens_hsa041140.53710639
112Rap1 signaling pathway_Homo sapiens_hsa040150.52313527
113Chemical carcinogenesis_Homo sapiens_hsa052040.51700444
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51411341
115Nitrogen metabolism_Homo sapiens_hsa009100.50480097
116VEGF signaling pathway_Homo sapiens_hsa043700.49019964
117Insulin signaling pathway_Homo sapiens_hsa049100.46426812
118Glycerolipid metabolism_Homo sapiens_hsa005610.46277402
119Prolactin signaling pathway_Homo sapiens_hsa049170.45331376
120Basal cell carcinoma_Homo sapiens_hsa052170.45124621
121RNA degradation_Homo sapiens_hsa030180.44318579
122Fatty acid degradation_Homo sapiens_hsa000710.43428869
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.42882507
124Propanoate metabolism_Homo sapiens_hsa006400.42185892
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41915471
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.40260305
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39001990
128Ovarian steroidogenesis_Homo sapiens_hsa049130.38997130
129Fatty acid metabolism_Homo sapiens_hsa012120.38822014
130Prion diseases_Homo sapiens_hsa050200.38423565
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36647949
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36489894
133Endocytosis_Homo sapiens_hsa041440.36389818
134Notch signaling pathway_Homo sapiens_hsa043300.36162600
135Non-small cell lung cancer_Homo sapiens_hsa052230.35964984
136Bile secretion_Homo sapiens_hsa049760.35684561
137Homologous recombination_Homo sapiens_hsa034400.35465463
138Colorectal cancer_Homo sapiens_hsa052100.34941619
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.33864391
140Chemokine signaling pathway_Homo sapiens_hsa040620.32226035
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31677164
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29696266

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