ZFHX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphangiogenesis (GO:0001946)4.80130565
2metanephric mesenchyme development (GO:0072075)4.40582367
3lymph vessel development (GO:0001945)4.31581300
4endothelial cell chemotaxis (GO:0035767)4.29027139
5cardiovascular system development (GO:0072358)4.21837499
6kidney morphogenesis (GO:0060993)4.16300099
7kidney mesenchyme development (GO:0072074)4.04318800
8sympathetic nervous system development (GO:0048485)3.94622351
9pyrimidine nucleobase catabolic process (GO:0006208)3.69763259
10lateral sprouting from an epithelium (GO:0060601)3.64794826
11negative chemotaxis (GO:0050919)3.64585168
12head development (GO:0060322)3.63692256
13outer ear morphogenesis (GO:0042473)3.63271935
14glomerulus development (GO:0032835)3.60489021
15embryonic camera-type eye morphogenesis (GO:0048596)3.57932051
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.56968640
17cerebellar Purkinje cell differentiation (GO:0021702)3.53752052
18semaphorin-plexin signaling pathway (GO:0071526)3.53016474
19negative regulation of axon guidance (GO:1902668)3.50210366
20retina layer formation (GO:0010842)3.42952618
21cardiac muscle cell proliferation (GO:0060038)3.41070631
22cell migration in hindbrain (GO:0021535)3.40545356
23negative regulation of fatty acid transport (GO:2000192)3.39486672
24limb development (GO:0060173)3.36404592
25appendage development (GO:0048736)3.36404592
26limb bud formation (GO:0060174)3.34826189
27retinal ganglion cell axon guidance (GO:0031290)3.31809642
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.30804766
29regulation of translation, ncRNA-mediated (GO:0045974)3.30804766
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30804766
31positive regulation of gastrulation (GO:2000543)3.22478218
32vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.19982495
33embryonic viscerocranium morphogenesis (GO:0048703)3.17348772
34phenol-containing compound catabolic process (GO:0019336)3.14255903
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.14077876
36coronary vasculature morphogenesis (GO:0060977)3.09053328
37peripheral nervous system neuron development (GO:0048935)3.06310760
38embryonic cranial skeleton morphogenesis (GO:0048701)3.03291633
39dopaminergic neuron differentiation (GO:0071542)3.02881907
40spinal cord development (GO:0021510)3.02737213
41metanephric nephron epithelium development (GO:0072243)3.00472450
42artery development (GO:0060840)2.99850209
43regulation of axon guidance (GO:1902667)2.98760892
44regulation of axon extension involved in axon guidance (GO:0048841)2.95955926
45cell proliferation in forebrain (GO:0021846)2.94623794
46embryonic heart tube development (GO:0035050)2.94575312
47cranial nerve morphogenesis (GO:0021602)2.92356726
48establishment of nucleus localization (GO:0040023)2.91974301
49negative regulation of stem cell proliferation (GO:2000647)2.90814755
50regulation of glomerular filtration (GO:0003093)2.90464937
51vascular endothelial growth factor signaling pathway (GO:0038084)2.90374062
52positive regulation of smoothened signaling pathway (GO:0045880)2.90040940
53neuron fate specification (GO:0048665)2.89030247
54camera-type eye morphogenesis (GO:0048593)2.88668766
55facial nerve structural organization (GO:0021612)2.88526366
56atrial septum morphogenesis (GO:0060413)2.88241986
57ganglion development (GO:0061548)2.87762974
58olfactory bulb development (GO:0021772)2.86061025
59female gonad development (GO:0008585)2.85704774
60cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.85670832
61primitive streak formation (GO:0090009)2.85247548
62microtubule depolymerization (GO:0007019)2.84930208
63neural tube development (GO:0021915)2.82708076
64striated muscle cell proliferation (GO:0014855)2.79823237
65regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78349267
66cranial nerve development (GO:0021545)2.78329882
67positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.77762948
68forelimb morphogenesis (GO:0035136)2.77631445
69establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.77420082
70regulation of pigment cell differentiation (GO:0050932)2.75944142
71embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75934839
72smooth muscle tissue development (GO:0048745)2.75192046
73regulation of somitogenesis (GO:0014807)2.74817817
74positive regulation of BMP signaling pathway (GO:0030513)2.74637045
75embryonic forelimb morphogenesis (GO:0035115)2.74396046
76pharyngeal system development (GO:0060037)2.73651012
77cytoplasmic mRNA processing body assembly (GO:0033962)2.73379145
78negative regulation of dendrite morphogenesis (GO:0050774)2.73344544
79regulation of fatty acid beta-oxidation (GO:0031998)2.72859348
80metanephric epithelium development (GO:0072207)2.72522252
81nucleus localization (GO:0051647)2.71761891
82generation of neurons (GO:0048699)2.70698228
83negative regulation of catenin import into nucleus (GO:0035414)2.69953711
84regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67350465
85embryonic eye morphogenesis (GO:0048048)2.67333164
86axon extension (GO:0048675)2.67159612
87proximal/distal pattern formation (GO:0009954)2.66582323
88heart morphogenesis (GO:0003007)2.65884252
89interkinetic nuclear migration (GO:0022027)2.64989223
90dopamine biosynthetic process (GO:0042416)2.64390186
91inner ear receptor stereocilium organization (GO:0060122)2.63724903
92mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63627279
93chondrocyte proliferation (GO:0035988)2.63360376
94histone H3-K4 trimethylation (GO:0080182)2.63008192
95forebrain neuron development (GO:0021884)2.62915295
96middle ear morphogenesis (GO:0042474)2.62759761
97nucleobase catabolic process (GO:0046113)2.61812362
98mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61466243
99mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61466243
100embryonic digit morphogenesis (GO:0042733)2.61318805
101neural crest cell development (GO:0014032)2.60871352
102cardiac ventricle formation (GO:0003211)2.60774287
103G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60262671
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.60012077
105histamine secretion (GO:0001821)2.59522520
106spinal cord association neuron differentiation (GO:0021527)2.58784154
107positive regulation of mesonephros development (GO:0061213)2.57816744
108establishment or maintenance of apical/basal cell polarity (GO:0035088)2.57609890
109establishment or maintenance of bipolar cell polarity (GO:0061245)2.57609890
110mesenchymal cell differentiation (GO:0048762)2.57471220
111cell differentiation involved in kidney development (GO:0061005)2.57306454
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.56979560
113regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.56174908
114positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54754948
115mesoderm formation (GO:0001707)2.53236637
116endothelial cell differentiation (GO:0045446)2.52951289
117cell differentiation in hindbrain (GO:0021533)2.52750277
118activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.52711162
119cell-cell junction maintenance (GO:0045217)2.52470987
120negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.52137908
121negative regulation of dendrite development (GO:2000171)2.51743337
122tooth mineralization (GO:0034505)2.51112801
123cardiac chamber formation (GO:0003207)2.49577334
124auditory behavior (GO:0031223)2.48459621
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.48336211
126endocardial cushion morphogenesis (GO:0003203)2.48042633
127establishment of tissue polarity (GO:0007164)2.47847259
128establishment of planar polarity (GO:0001736)2.47847259
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47496167
130uterus development (GO:0060065)2.47426764
131mesenchymal cell development (GO:0014031)2.47248077
132regulation of NFAT protein import into nucleus (GO:0051532)2.47112427
133embryonic limb morphogenesis (GO:0030326)2.46919090
134embryonic appendage morphogenesis (GO:0035113)2.46919090
135eye morphogenesis (GO:0048592)2.46710778
136regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46544669
137appendage morphogenesis (GO:0035107)2.46331064
138limb morphogenesis (GO:0035108)2.46331064
139regulation of mesonephros development (GO:0061217)2.46178820
140negative regulation of myotube differentiation (GO:0010832)2.46043780
141negative regulation of glial cell proliferation (GO:0060253)2.44989009
142microglial cell activation (GO:0001774)2.44767620
143axonal fasciculation (GO:0007413)2.44238124
144positive regulation of axon extension (GO:0045773)2.44161329
145behavioral response to nicotine (GO:0035095)2.43671219
146forebrain neuron differentiation (GO:0021879)2.43594960
147negative regulation of homotypic cell-cell adhesion (GO:0034111)2.42595185
148axon extension involved in axon guidance (GO:0048846)2.42462341
149neuron projection extension involved in neuron projection guidance (GO:1902284)2.42462341
150muscle cell proliferation (GO:0033002)2.42382458
151hindbrain development (GO:0030902)2.41735761
152left/right pattern formation (GO:0060972)2.41661194
153plasma membrane repair (GO:0001778)2.41495003
154positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.41333644
155palate development (GO:0060021)2.40436999
156regulation of mesenchymal cell proliferation (GO:0010464)2.39700158
157venous blood vessel morphogenesis (GO:0048845)2.38702722
158regulation of endothelial cell chemotaxis (GO:2001026)2.38675995
159metanephric tubule development (GO:0072170)2.35200156
160metanephric nephron tubule development (GO:0072234)2.35200156
161blood vessel endothelial cell migration (GO:0043534)2.31315873
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.30184753
163positive regulation of fatty acid beta-oxidation (GO:0032000)2.30100271
164blood vessel morphogenesis (GO:0048514)2.29855823
165nephron epithelium development (GO:0072009)2.29681816
166dopamine receptor signaling pathway (GO:0007212)2.27976696
167regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27968203
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26745742
169ear development (GO:0043583)2.24483993
170regulation of hippo signaling (GO:0035330)2.23432617
171phospholipid translocation (GO:0045332)2.23088376
172lipid translocation (GO:0034204)2.23088376
173somitogenesis (GO:0001756)2.21176415
174establishment of spindle localization (GO:0051293)2.21174828
175substrate-dependent cell migration (GO:0006929)2.20543198
176morphogenesis of an epithelial sheet (GO:0002011)2.20540255
177formation of primary germ layer (GO:0001704)2.20413851
178glucocorticoid receptor signaling pathway (GO:0042921)2.18846915
179collecting duct development (GO:0072044)2.18318372
180artery morphogenesis (GO:0048844)2.18019368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.32927513
2GBX2_23144817_ChIP-Seq_PC3_Human3.26202169
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18382148
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.90445862
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87362857
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.66507958
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46014748
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43090803
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.37884404
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.35033859
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32906350
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29348396
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27964151
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.24644180
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19465705
16TAF15_26573619_Chip-Seq_HEK293_Human2.18891361
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16601032
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.15804806
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.11904743
20* KDM2B_26808549_Chip-Seq_K562_Human2.07110830
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06970806
22RNF2_27304074_Chip-Seq_NSC_Mouse2.05739631
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.99900218
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99618753
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97070639
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97070639
27DROSHA_22980978_ChIP-Seq_HELA_Human1.96151048
28* P300_19829295_ChIP-Seq_ESCs_Human1.95428768
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93647331
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90540197
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90382128
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.90204091
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.88063780
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86592912
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85971919
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84859021
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79303463
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78352858
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.77910649
40* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76853437
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75820084
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.75446226
43* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.73310605
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.73053688
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.72559288
46EWS_26573619_Chip-Seq_HEK293_Human1.71283244
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68155858
48VDR_21846776_ChIP-Seq_THP-1_Human1.67489459
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66394230
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65261355
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63221743
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63216260
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62644238
54LXR_22292898_ChIP-Seq_THP-1_Human1.62192256
55AHR_22903824_ChIP-Seq_MCF-7_Human1.61714097
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.59224337
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58927298
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57390441
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56524329
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56318656
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.55577082
62* ARNT_22903824_ChIP-Seq_MCF-7_Human1.53289583
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.53226858
64* KDM2B_26808549_Chip-Seq_DND41_Human1.52037683
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51782735
66FUS_26573619_Chip-Seq_HEK293_Human1.51552174
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49576950
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47709763
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47709763
70IGF1R_20145208_ChIP-Seq_DFB_Human1.47224834
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.47126349
72VDR_22108803_ChIP-Seq_LS180_Human1.46917190
73* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46705365
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43321289
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43278479
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.43096006
77* EZH2_27294783_Chip-Seq_ESCs_Mouse1.42469132
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41748383
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39489970
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39445179
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39249789
82* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39214727
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38383116
84* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37800609
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37271879
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34948316
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34461091
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34216928
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33741486
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33511607
91* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31802616
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.31785604
93* TP53_18474530_ChIP-ChIP_U2OS_Human1.31662287
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.31098768
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29891730
96* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29366882
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28971233
98AR_25329375_ChIP-Seq_VCAP_Human1.28718236
99* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28435948
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28291029
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28039865
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27945744
103RUNX2_22187159_ChIP-Seq_PCA_Human1.26024592
104* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25561778
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24716860
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23688631
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23056575
108ER_23166858_ChIP-Seq_MCF-7_Human1.23041302
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22448934
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22440147
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21270526
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20859503
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20806945
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.18884179
115* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17846661
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.17800105
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.17611279
118* STAT3_23295773_ChIP-Seq_U87_Human1.16909517
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16498471
120TRIM28_21343339_ChIP-Seq_HEK293_Human1.14938243
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.14625212
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.14566344
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14468627
124AR_19668381_ChIP-Seq_PC3_Human1.14360757
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14274622
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14240146
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.13844347
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12734951
129ZNF274_21170338_ChIP-Seq_K562_Hela1.12135734
130AR_21572438_ChIP-Seq_LNCaP_Human1.11768610
131* TCF7_22412390_ChIP-Seq_EML_Mouse1.11500984
132CJUN_26792858_Chip-Seq_BT549_Human1.11166283
133CTCF_27219007_Chip-Seq_Bcells_Human1.10600208
134JUN_21703547_ChIP-Seq_K562_Human1.10366396
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09625535
136* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09527682
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09252653
138P53_22387025_ChIP-Seq_ESCs_Mouse1.08306963
139TP53_20018659_ChIP-ChIP_R1E_Mouse1.07823953
140TP53_16413492_ChIP-PET_HCT116_Human1.07731053
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07402650
142* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06638035
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06479656
144TCF4_23295773_ChIP-Seq_U87_Human1.06091591
145* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04329443
146TP53_22127205_ChIP-Seq_IMR90_Human1.04218108
147* RACK7_27058665_Chip-Seq_MCF-7_Human1.03853165
148P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02167672
149* CREB1_26743006_Chip-Seq_LNCaP_Human1.00755632
150* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99042329
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98887501
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97358043
153REST_21632747_ChIP-Seq_MESCs_Mouse0.96652787
154MYC_27129775_Chip-Seq_CORNEA_Mouse0.94602482
155SCL_19346495_ChIP-Seq_HPC-7_Human0.92583231
156* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92054253
157MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90771324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.63467801
2MP0005623_abnormal_meninges_morphology3.35555872
3MP0005076_abnormal_cell_differentiation3.35261841
4MP0000569_abnormal_digit_pigmentation3.30466045
5MP0003283_abnormal_digestive_organ2.87586039
6MP0009053_abnormal_anal_canal2.79514212
7MP0003385_abnormal_body_wall2.78203349
8MP0008789_abnormal_olfactory_epithelium2.72997777
9MP0001188_hyperpigmentation2.61207153
10MP0010030_abnormal_orbit_morphology2.60939767
11MP0009250_abnormal_appendicular_skeleto2.49081146
12MP0002102_abnormal_ear_morphology2.45442712
13MP0006276_abnormal_autonomic_nervous2.40533735
14MP0000566_synostosis2.36434895
15MP0003941_abnormal_skin_development2.30199045
16MP0003121_genomic_imprinting2.30183443
17MP0003045_fibrosis2.28340824
18MP0005394_taste/olfaction_phenotype2.26303840
19MP0005499_abnormal_olfactory_system2.26303840
20MP0004133_heterotaxia2.24365250
21MP0003705_abnormal_hypodermis_morpholog2.21118784
22MP0005167_abnormal_blood-brain_barrier2.20202198
23MP0010368_abnormal_lymphatic_system2.19062032
24MP0003942_abnormal_urinary_system2.17888866
25MP0002938_white_spotting2.17524448
26MP0003890_abnormal_embryonic-extraembry2.14941140
27MP0005409_darkened_coat_color2.11579978
28MP0000049_abnormal_middle_ear2.09112030
29MP0000778_abnormal_nervous_system1.99821229
30MP0002751_abnormal_autonomic_nervous1.99376985
31MP0009379_abnormal_foot_pigmentation1.98598575
32MP0003091_abnormal_cell_migration1.98232140
33MP0005503_abnormal_tendon_morphology1.97654457
34MP0000733_abnormal_muscle_development1.96508136
35MP0003787_abnormal_imprinting1.90579429
36MP0004858_abnormal_nervous_system1.85473580
37MP0003755_abnormal_palate_morphology1.75105318
38MP0002177_abnormal_outer_ear1.73051270
39MP0003937_abnormal_limbs/digits/tail_de1.72223542
40MP0000534_abnormal_ureter_morphology1.70113012
41MP0002233_abnormal_nose_morphology1.69056388
42MP0006292_abnormal_olfactory_placode1.68064132
43MP0000538_abnormal_urinary_bladder1.62459949
44MP0001986_abnormal_taste_sensitivity1.50251665
45MP0004130_abnormal_muscle_cell1.47966139
46MP0001905_abnormal_dopamine_level1.46882190
47MP0001299_abnormal_eye_distance/1.46249075
48MP0003938_abnormal_ear_development1.45685651
49MP0001502_abnormal_circadian_rhythm1.45511291
50MP0002184_abnormal_innervation1.44393119
51MP0005257_abnormal_intraocular_pressure1.43749212
52MP0002282_abnormal_trachea_morphology1.43261198
53MP0005645_abnormal_hypothalamus_physiol1.41959272
54MP0000015_abnormal_ear_pigmentation1.41020994
55MP0001529_abnormal_vocalization1.39226888
56MP0002092_abnormal_eye_morphology1.38467174
57MP0005248_abnormal_Harderian_gland1.37910577
58MP0001346_abnormal_lacrimal_gland1.37253582
59MP0002116_abnormal_craniofacial_bone1.37090829
60MP0001915_intracranial_hemorrhage1.35606826
61MP0009697_abnormal_copulation1.34805072
62MP0003279_aneurysm1.34419031
63MP0004270_analgesia1.33016852
64MP0002277_abnormal_respiratory_mucosa1.32541443
65MP0002163_abnormal_gland_morphology1.31105534
66MP0002734_abnormal_mechanical_nocicepti1.29079732
67MP0000631_abnormal_neuroendocrine_gland1.27287988
68MP0001958_emphysema1.26472088
69MP0009278_abnormal_bone_marrow1.25554209
70MP0002249_abnormal_larynx_morphology1.24434195
71MP0008438_abnormal_cutaneous_collagen1.24241046
72MP0001984_abnormal_olfaction1.23142610
73MP0004134_abnormal_chest_morphology1.23037320
74MP0005171_absent_coat_pigmentation1.20615087
75MP0004272_abnormal_basement_membrane1.20227378
76MP0005197_abnormal_uvea_morphology1.19126411
77MP0002735_abnormal_chemical_nociception1.18989909
78MP0001968_abnormal_touch/_nociception1.17861261
79MP0008961_abnormal_basal_metabolism1.17524823
80MP0003935_abnormal_craniofacial_develop1.14480402
81MP0002109_abnormal_limb_morphology1.13247529
82MP0002557_abnormal_social/conspecific_i1.13094418
83MP0000462_abnormal_digestive_system1.12795753
84MP0002168_other_aberrant_phenotype1.12685285
85MP0001286_abnormal_eye_development1.11779772
86MP0004233_abnormal_muscle_weight1.10506638
87MP0002697_abnormal_eye_size1.09183732
88MP0003880_abnormal_central_pattern1.08696440
89MP0000428_abnormal_craniofacial_morphol1.07917660
90MP0002932_abnormal_joint_morphology1.06792089
91MP0005423_abnormal_somatic_nervous1.06073111
92MP0005187_abnormal_penis_morphology1.05854542
93MP0004145_abnormal_muscle_electrophysio1.05400729
94MP0000432_abnormal_head_morphology1.05102390
95MP0005508_abnormal_skeleton_morphology1.04805441
96MP0005670_abnormal_white_adipose1.02354263
97MP0010352_gastrointestinal_tract_polyps1.02175150
98MP0002009_preneoplasia1.02056327
99MP0000955_abnormal_spinal_cord1.01910788
100MP0002877_abnormal_melanocyte_morpholog1.00592103
101MP0002138_abnormal_hepatobiliary_system1.00436570
102MP0000537_abnormal_urethra_morphology1.00044922
103MP0000516_abnormal_urinary_system0.99726125
104MP0005367_renal/urinary_system_phenotyp0.99726125
105MP0001270_distended_abdomen0.99338350
106MP0004859_abnormal_synaptic_plasticity0.98794821
107MP0004883_abnormal_blood_vessel0.98738616
108MP0003315_abnormal_perineum_morphology0.96918383
109MP0000762_abnormal_tongue_morphology0.94775074
110MP0000681_abnormal_thyroid_gland0.94459011
111MP0003861_abnormal_nervous_system0.93880785
112MP0002925_abnormal_cardiovascular_devel0.93835262
113MP0000026_abnormal_inner_ear0.93410485
114MP0005646_abnormal_pituitary_gland0.92910909
115MP0003115_abnormal_respiratory_system0.92824288
116MP0002152_abnormal_brain_morphology0.92754093
117MP0002332_abnormal_exercise_endurance0.90051133
118MP0005595_abnormal_vascular_smooth0.88944839
119MP0002081_perinatal_lethality0.88627177
120MP0005220_abnormal_exocrine_pancreas0.88389918
121MP0000678_abnormal_parathyroid_gland0.88060728
122MP0000372_irregular_coat_pigmentation0.86313671
123MP0000003_abnormal_adipose_tissue0.85445074
124MP0004185_abnormal_adipocyte_glucose0.85266947
125MP0002736_abnormal_nociception_after0.84677347
126MP0003453_abnormal_keratinocyte_physiol0.84496121
127MP0002638_abnormal_pupillary_reflex0.84415788
128MP0001879_abnormal_lymphatic_vessel0.83989574
129MP0003868_abnormal_feces_composition0.83878414
130MP0004510_myositis0.82867905
131MP0002234_abnormal_pharynx_morphology0.82492846
132MP0005379_endocrine/exocrine_gland_phen0.81976445
133MP0002114_abnormal_axial_skeleton0.80810806
134MP0002752_abnormal_somatic_nervous0.80569807
135MP0001340_abnormal_eyelid_morphology0.80446598
136MP0002115_abnormal_skeleton_extremities0.80273099
137MP0005275_abnormal_skin_tensile0.80250043
138MP0004808_abnormal_hematopoietic_stem0.79028720
139MP0000767_abnormal_smooth_muscle0.78231794
140MP0003948_abnormal_gas_homeostasis0.78204831
141MP0002108_abnormal_muscle_morphology0.77570687
142MP0002733_abnormal_thermal_nociception0.77510010
143MP0001324_abnormal_eye_pigmentation0.77195306
144MP0000163_abnormal_cartilage_morphology0.76961508
145MP0001348_abnormal_lacrimal_gland0.76712178
146MP0002089_abnormal_postnatal_growth/wei0.76043692
147MP0008057_abnormal_DNA_replication0.75746683
148MP0001849_ear_inflammation0.75475039
149MP0003329_amyloid_beta_deposits0.74751106
150MP0002882_abnormal_neuron_morphology0.71935655
151MP0010386_abnormal_urinary_bladder0.71658864
152MP0004742_abnormal_vestibular_system0.71455506
153MP0002063_abnormal_learning/memory/cond0.71255335
154MP0000759_abnormal_skeletal_muscle0.69659682
155MP0002128_abnormal_blood_circulation0.69572276
156MP0001944_abnormal_pancreas_morphology0.69322205

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.90343005
2Hypothermia (HP:0002045)3.89762750
3Abnormality of the nasal septum (HP:0000419)3.52908910
4Ulnar bowing (HP:0003031)3.49029285
5Morphological abnormality of the middle ear (HP:0008609)3.38932112
6Broad face (HP:0000283)3.38285397
7Urethral obstruction (HP:0000796)3.06582161
8Midline defect of the nose (HP:0004122)2.98968129
9Renovascular hypertension (HP:0100817)2.96517057
10Abnormality of the distal phalanx of the thumb (HP:0009617)2.96324255
11Cutaneous finger syndactyly (HP:0010554)2.95736462
12Broad distal phalanx of finger (HP:0009836)2.92178251
13Obstructive sleep apnea (HP:0002870)2.85161444
14Abnormality of the fingertips (HP:0001211)2.84051077
15Absent eyebrow (HP:0002223)2.82635295
16Abnormality of the nasolacrimal system (HP:0000614)2.81954032
17Abnormal hair whorl (HP:0010721)2.80390815
18Asymmetry of the thorax (HP:0001555)2.78042905
19Overgrowth (HP:0001548)2.77211628
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74895228
21Short 4th metacarpal (HP:0010044)2.74895228
22Shallow orbits (HP:0000586)2.72580595
23Turricephaly (HP:0000262)2.71826823
24Cerebral aneurysm (HP:0004944)2.70215750
25Abnormality of incisor morphology (HP:0011063)2.67819251
26Limb dystonia (HP:0002451)2.65822577
27Spinal cord lesions (HP:0100561)2.65232596
28Syringomyelia (HP:0003396)2.65232596
29Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.63898638
30Prostate neoplasm (HP:0100787)2.63594536
31Hepatoblastoma (HP:0002884)2.61818978
32Persistence of primary teeth (HP:0006335)2.56420086
33Elfin facies (HP:0004428)2.54780141
34Abnormality of the radial head (HP:0003995)2.52680733
35Congenital malformation of the right heart (HP:0011723)2.52499220
36Double outlet right ventricle (HP:0001719)2.52499220
37Papillary thyroid carcinoma (HP:0002895)2.52163917
38Renal duplication (HP:0000075)2.50485984
39Narrow nasal bridge (HP:0000446)2.50077894
40Increased number of teeth (HP:0011069)2.49974331
41Renal hypoplasia (HP:0000089)2.49585311
42Abnormality of the lacrimal duct (HP:0011481)2.49385139
43Dislocated radial head (HP:0003083)2.45250358
44Submucous cleft hard palate (HP:0000176)2.44662744
45Cutaneous syndactyly (HP:0012725)2.42689444
46Germ cell neoplasia (HP:0100728)2.41552553
47Myelomeningocele (HP:0002475)2.40998856
48Protruding tongue (HP:0010808)2.36942268
49Exotropia (HP:0000577)2.36744177
50Long eyelashes (HP:0000527)2.35226550
51Radial bowing (HP:0002986)2.33414154
52Thyroid carcinoma (HP:0002890)2.32536721
53Periauricular skin pits (HP:0100277)2.30812571
54Preauricular pit (HP:0004467)2.30812571
55Bowing of the arm (HP:0006488)2.30130883
56Bowed forearm bones (HP:0003956)2.30130883
57Laryngomalacia (HP:0001601)2.24933756
58Lip pit (HP:0100267)2.24875606
59Shawl scrotum (HP:0000049)2.24443826
60Adrenal hypoplasia (HP:0000835)2.24162331
61Abnormality of the right ventricle (HP:0001707)2.22790552
62Short tibia (HP:0005736)2.22103952
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.21326984
64Macroorchidism (HP:0000053)2.20642667
65Overriding aorta (HP:0002623)2.17999460
66Abnormality of the ischium (HP:0003174)2.17239687
67Long toe (HP:0010511)2.16826434
68Natal tooth (HP:0000695)2.15252525
69Genetic anticipation (HP:0003743)2.14638915
70Bronchomalacia (HP:0002780)2.14289575
71Transposition of the great arteries (HP:0001669)2.13802809
72Abnormal connection of the cardiac segments (HP:0011545)2.13802809
73Abnormal ventriculo-arterial connection (HP:0011563)2.13802809
74Mitral valve prolapse (HP:0001634)2.13676608
75Flat cornea (HP:0007720)2.13415188
76Abnormality of the phalanges of the hallux (HP:0010057)2.12321337
77Dysmetric saccades (HP:0000641)2.12161012
78Heterotopia (HP:0002282)2.09440823
79Abnormality of the incisor (HP:0000676)2.08702336
80Bifid tongue (HP:0010297)2.06803839
81Abnormal number of incisors (HP:0011064)2.06157697
82Aplasia involving bones of the upper limbs (HP:0009823)2.06006582
83Aplasia of the phalanges of the hand (HP:0009802)2.06006582
84Aplasia involving bones of the extremities (HP:0009825)2.06006582
85Wrist flexion contracture (HP:0001239)2.05392237
86Renal dysplasia (HP:0000110)2.04414869
87Ulnar claw (HP:0001178)2.02158027
88Bilateral microphthalmos (HP:0007633)2.00117966
89Megalocornea (HP:0000485)1.95728233
90Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95184460
91Hypoplasia of the iris (HP:0007676)1.95053118
92Abnormality of the epiphyses of the hand (HP:0005924)1.94670979
93Skull defect (HP:0001362)1.94379194
94Patellar dislocation (HP:0002999)1.93963738
95Rectal prolapse (HP:0002035)1.93285837
96Nasolacrimal duct obstruction (HP:0000579)1.93125966
97Abnormality of the parietal bone (HP:0002696)1.90869424
98Intestinal atresia (HP:0011100)1.90416191
99Mesomelia (HP:0003027)1.89630749
100Hyperventilation (HP:0002883)1.87537319
101Bladder diverticulum (HP:0000015)1.87000159
102Bicuspid aortic valve (HP:0001647)1.85986935
103Abnormality of the aortic arch (HP:0012303)1.85409785
104Aqueductal stenosis (HP:0002410)1.85407634
105Hypoplasia of the maxilla (HP:0000327)1.85266522
106Failure to thrive in infancy (HP:0001531)1.84906361
107Broad toe (HP:0001837)1.84731948
108Intestinal fistula (HP:0100819)1.84690017
109Absent frontal sinuses (HP:0002688)1.84495139
110Ureteral stenosis (HP:0000071)1.83529211
111Aplasia of the musculature (HP:0100854)1.82781217
112Neonatal short-limb short stature (HP:0008921)1.81907209
113Intellectual disability, moderate (HP:0002342)1.81305594
114Microglossia (HP:0000171)1.81098926
115Fibular aplasia (HP:0002990)1.80860351
116Precocious puberty (HP:0000826)1.80823881
117Abnormality of the 4th metacarpal (HP:0010012)1.80767908
118Nasal speech (HP:0001611)1.80213092
119Disproportionate tall stature (HP:0001519)1.79683527
120Embryonal renal neoplasm (HP:0011794)1.79039750
121Ureteral obstruction (HP:0006000)1.77003159
122Genital tract atresia (HP:0001827)1.76795850
123Abnormality of the intervertebral disk (HP:0005108)1.76670447
124Nephroblastoma (Wilms tumor) (HP:0002667)1.76029369
125Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.75939425
126Infantile muscular hypotonia (HP:0008947)1.75479025
127Tracheomalacia (HP:0002779)1.75451416
128Tented upper lip vermilion (HP:0010804)1.74573817
129Anophthalmia (HP:0000528)1.73378379
130Pointed chin (HP:0000307)1.73361978
131Flat acetabular roof (HP:0003180)1.73262131
132Oligodontia (HP:0000677)1.71743417
133Abnormal pancreas size (HP:0012094)1.71696421
134Obsessive-compulsive behavior (HP:0000722)1.71553753
135Febrile seizures (HP:0002373)1.71313165
136Neoplasm of the adrenal cortex (HP:0100641)1.71270180
137Abnormality of the humeroradial joint (HP:0100744)1.71243179
138Aplasia cutis congenita (HP:0001057)1.70605617
139Broad finger (HP:0001500)1.70026125
140Vaginal atresia (HP:0000148)1.69997791
141Neonatal death (HP:0003811)1.69594160
142Limited elbow extension (HP:0001377)1.68523602
143Arnold-Chiari malformation (HP:0002308)1.68458138
144Arterial tortuosity (HP:0005116)1.68377445
145Short clavicles (HP:0000894)1.67337850
146Broad thumb (HP:0011304)1.66975638
147Downturned corners of mouth (HP:0002714)1.66796996
148Volvulus (HP:0002580)1.66796995
149Advanced eruption of teeth (HP:0006288)1.65945817
150Pulmonary artery stenosis (HP:0004415)1.65411300
151Hyporeflexia of lower limbs (HP:0002600)1.65187723
152Narrow palate (HP:0000189)1.65089874
153Truncal obesity (HP:0001956)1.64983988
154Broad phalanges of the hand (HP:0009768)1.64832709
155Lymphangioma (HP:0100764)1.64523303
156Long foot (HP:0001833)1.64404589
157Flat face (HP:0012368)1.64174711
158Fragile skin (HP:0001030)1.63936920
159Short nail (HP:0001799)1.63098510
160Ectopic anus (HP:0004397)1.62984542
161Vascular tortuosity (HP:0004948)1.62061981
162Wide anterior fontanel (HP:0000260)1.62006904
163High anterior hairline (HP:0009890)1.61298737
164Short metatarsal (HP:0010743)1.61219820
165Sleep apnea (HP:0010535)1.60966146
166Aplasia/Hypoplasia of the clavicles (HP:0006710)1.60173956
167Preaxial hand polydactyly (HP:0001177)1.60058466
168Progressive cerebellar ataxia (HP:0002073)1.59750962
169Heterochromia iridis (HP:0001100)1.59319907
170Abnormality of the parathyroid morphology (HP:0011766)1.59166581
171Camptodactyly of toe (HP:0001836)1.59015951
172Atelectasis (HP:0100750)1.58944109
173Partial duplication of the phalanx of hand (HP:0009999)1.58671111
174Osteomalacia (HP:0002749)1.57855385
175Short middle phalanx of the 5th finger (HP:0004220)1.57395125
176Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.57304049
177Increased corneal curvature (HP:0100692)1.57052553
178Keratoconus (HP:0000563)1.57052553
179Tubulointerstitial nephritis (HP:0001970)1.56303460
180Growth hormone deficiency (HP:0000824)1.56052972
181Medial flaring of the eyebrow (HP:0010747)1.55999158
182Aplasia/Hypoplasia of the lens (HP:0008063)1.54421990
183Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52579971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.48014066
2SIK34.25949578
3TRIB33.92936910
4TTN3.90277571
5BMPR1B3.28903833
6ERBB33.07203872
7EEF2K3.02760814
8ICK2.66757245
9MAPK132.63593299
10MARK12.61274807
11GRK72.55840823
12BCR2.34010894
13AKT32.32331916
14CAMK1G2.28530345
15IRAK32.13988459
16YES12.03481075
17MAPKAPK32.02429836
18EPHB22.00044831
19MTOR1.96171281
20DYRK21.93425629
21CAMK1D1.88011421
22TGFBR21.84194309
23MAP3K101.81640903
24PKN21.68520011
25SGK21.67449170
26FRK1.57819694
27PRKD31.49006960
28ZAK1.48919276
29CDK81.45205020
30SMG11.44922605
31SIK21.43465465
32NUAK11.38585625
33TGFBR11.34045201
34TIE11.33058406
35SRPK11.32419821
36MKNK11.31405481
37EPHA31.28535732
38MAP3K61.21485066
39MKNK21.20251569
40LATS11.19861298
41WNK31.14879768
42MINK11.12439451
43SGK2231.11304779
44SGK4941.11304779
45TRPM71.08344545
46ADRBK11.06952076
47ADRBK21.06278086
48PNCK1.04407914
49RPS6KB21.02188792
50PLK21.01787332
51CAMK41.01754704
52MAP2K41.00819854
53CSNK1G30.98386490
54GRK50.97547093
55RPS6KA20.96123578
56EIF2AK20.95994228
57WNK10.95778574
58SIK10.94727318
59TYRO30.94053968
60KSR10.93802821
61RIPK10.92378467
62CSNK1G10.92325910
63UHMK10.91514588
64PDGFRB0.88909507
65BLK0.87595063
66CSNK1A1L0.87422374
67FGFR40.86134103
68FER0.86094877
69LATS20.85759661
70FGFR30.85756136
71PRKAA10.84690678
72MAP2K70.84071933
73CDK120.82736581
74PTK20.81931075
75RET0.81202884
76SGK30.79985715
77MAPK150.78924142
78STK38L0.78351936
79BRD40.77094216
80PLK30.76995716
81PDGFRA0.76051882
82PIM20.75910384
83DDR20.75234457
84ROCK10.74766306
85NTRK20.74530086
86INSRR0.74103645
87MAP3K70.73747922
88SGK10.70147098
89ERBB20.69405975
90BMPR20.67593341
91MAPK110.67558656
92PRPF4B0.67548487
93CSNK1G20.67448622
94NEK60.67236442
95TLK10.66936616
96MAPK120.66902613
97PRKCE0.66725824
98MAP2K30.66646096
99CAMK2B0.65243694
100CAMKK10.64873703
101TNIK0.64783534
102CDK30.63846443
103RPS6KA50.63705039
104FGFR20.59694052
105IRAK10.59277883
106PAK20.59114443
107CDC42BPA0.59051038
108STK110.56930484
109MAP3K120.56521924
110PKN10.55607395
111PRKD20.55204094
112LIMK10.55095879
113VRK10.53416244
114RPS6KC10.52840567
115RPS6KL10.52840567
116MAPK40.52161307
117AKT10.51844123
118MYLK0.51818073
119PRKAA20.50401935
120CHEK20.47805535
121RPS6KA10.46645751
122IRAK20.45579019
123PRKG10.44862206
124NEK90.44549680
125CAMK2G0.43849936
126CHUK0.43470206
127MAP3K20.42235716
128TAOK10.41975179
129CDK90.41859227
130MAPK10.41834529
131MARK20.41720317
132PHKG20.40616322
133PHKG10.40616322
134MAP3K10.40394370
135RPS6KB10.40271289
136STK380.39952278
137PIK3CA0.39766563
138PAK30.39724865
139HIPK20.39585123
140PRKCH0.38986664
141ATM0.37676968
142MAPK80.36783371
143MAPKAPK50.35184597
144RPS6KA60.35149292
145TAOK20.34127775
146MAP3K40.34070546
147CAMK2A0.33623486
148GSK3A0.32535291
149GSK3B0.32329643
150MAPK140.31824286
151IRAK40.30911123
152MAPKAPK20.30355359
153NTRK30.30146407
154NME10.29672350
155STK390.29324622
156MAPK100.29104935

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.44765842
2Axon guidance_Homo sapiens_hsa043602.25963991
3Systemic lupus erythematosus_Homo sapiens_hsa053221.96104106
4Alcoholism_Homo sapiens_hsa050341.79530402
5Hedgehog signaling pathway_Homo sapiens_hsa043401.78172406
6Basal cell carcinoma_Homo sapiens_hsa052171.74177533
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.72810668
8TGF-beta signaling pathway_Homo sapiens_hsa043501.66619828
9Serotonergic synapse_Homo sapiens_hsa047261.65973278
10Adherens junction_Homo sapiens_hsa045201.61624034
11Type II diabetes mellitus_Homo sapiens_hsa049301.59667308
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.58781226
13* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.58371173
14Non-small cell lung cancer_Homo sapiens_hsa052231.50976066
15VEGF signaling pathway_Homo sapiens_hsa043701.48234425
16Cocaine addiction_Homo sapiens_hsa050301.48022882
17Dorso-ventral axis formation_Homo sapiens_hsa043201.47048064
18Wnt signaling pathway_Homo sapiens_hsa043101.45713820
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45194676
20Hippo signaling pathway_Homo sapiens_hsa043901.44191413
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.40725747
22Nicotine addiction_Homo sapiens_hsa050331.39386444
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37848421
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34733648
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30782650
26mTOR signaling pathway_Homo sapiens_hsa041501.30131435
27Prostate cancer_Homo sapiens_hsa052151.27251104
28Colorectal cancer_Homo sapiens_hsa052101.26363273
29Melanoma_Homo sapiens_hsa052181.25888811
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.25011538
31Taste transduction_Homo sapiens_hsa047421.24166073
32Endometrial cancer_Homo sapiens_hsa052131.23416544
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23208386
34ABC transporters_Homo sapiens_hsa020101.19894220
35Melanogenesis_Homo sapiens_hsa049161.18564603
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18249471
37Bladder cancer_Homo sapiens_hsa052191.15818300
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15672203
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15168220
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14692026
41Inositol phosphate metabolism_Homo sapiens_hsa005621.14326831
42Phototransduction_Homo sapiens_hsa047441.09801015
43Cholinergic synapse_Homo sapiens_hsa047251.08598360
44Estrogen signaling pathway_Homo sapiens_hsa049151.07660466
45MicroRNAs in cancer_Homo sapiens_hsa052061.07651162
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07534227
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06258065
48Dilated cardiomyopathy_Homo sapiens_hsa054141.04949748
49Phagosome_Homo sapiens_hsa041451.02537367
50Pathways in cancer_Homo sapiens_hsa052001.02382669
51Dopaminergic synapse_Homo sapiens_hsa047281.02202187
52Choline metabolism in cancer_Homo sapiens_hsa052311.01250161
53Notch signaling pathway_Homo sapiens_hsa043301.00517884
54ECM-receptor interaction_Homo sapiens_hsa045120.99490049
55Small cell lung cancer_Homo sapiens_hsa052220.99244337
56African trypanosomiasis_Homo sapiens_hsa051430.93817893
57ErbB signaling pathway_Homo sapiens_hsa040120.93033669
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91878833
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90183455
60Viral myocarditis_Homo sapiens_hsa054160.89827603
61AMPK signaling pathway_Homo sapiens_hsa041520.89615509
62Rap1 signaling pathway_Homo sapiens_hsa040150.88782506
63Gap junction_Homo sapiens_hsa045400.87603086
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87470848
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87162757
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86841758
67Long-term depression_Homo sapiens_hsa047300.86602580
68Prolactin signaling pathway_Homo sapiens_hsa049170.86228803
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.86091632
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85476084
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84457741
72Acute myeloid leukemia_Homo sapiens_hsa052210.84121760
73Parkinsons disease_Homo sapiens_hsa050120.82954824
74Olfactory transduction_Homo sapiens_hsa047400.82308306
75Sulfur relay system_Homo sapiens_hsa041220.82168108
76Long-term potentiation_Homo sapiens_hsa047200.81917977
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81720527
78Calcium signaling pathway_Homo sapiens_hsa040200.81671122
79Oxytocin signaling pathway_Homo sapiens_hsa049210.81539375
80Renin secretion_Homo sapiens_hsa049240.80483285
81Insulin signaling pathway_Homo sapiens_hsa049100.78887434
82Lysine degradation_Homo sapiens_hsa003100.77690569
83Renal cell carcinoma_Homo sapiens_hsa052110.76448155
84GnRH signaling pathway_Homo sapiens_hsa049120.76313698
85Oxidative phosphorylation_Homo sapiens_hsa001900.75166051
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74732083
87Viral carcinogenesis_Homo sapiens_hsa052030.73920769
88Platelet activation_Homo sapiens_hsa046110.72796060
89Amoebiasis_Homo sapiens_hsa051460.72744833
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71939591
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71797359
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.71758334
93MAPK signaling pathway_Homo sapiens_hsa040100.71343202
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.71086849
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70665434
96Proteoglycans in cancer_Homo sapiens_hsa052050.70615076
97Gastric acid secretion_Homo sapiens_hsa049710.70575899
98Amphetamine addiction_Homo sapiens_hsa050310.70327737
99Alzheimers disease_Homo sapiens_hsa050100.70125841
100Focal adhesion_Homo sapiens_hsa045100.70023227
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69349301
102Glutamatergic synapse_Homo sapiens_hsa047240.69203756
103Basal transcription factors_Homo sapiens_hsa030220.68642574
104GABAergic synapse_Homo sapiens_hsa047270.68155550
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68110293
106Vitamin B6 metabolism_Homo sapiens_hsa007500.67589982
107Huntingtons disease_Homo sapiens_hsa050160.66897553
108Arachidonic acid metabolism_Homo sapiens_hsa005900.66587192
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66519002
110Malaria_Homo sapiens_hsa051440.66261566
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66156538
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66016489
113Salivary secretion_Homo sapiens_hsa049700.63428285
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.63339289
115Thyroid cancer_Homo sapiens_hsa052160.62827785
116Ether lipid metabolism_Homo sapiens_hsa005650.62554958
117HIF-1 signaling pathway_Homo sapiens_hsa040660.62147797
118mRNA surveillance pathway_Homo sapiens_hsa030150.62117618
119Rheumatoid arthritis_Homo sapiens_hsa053230.60488644
120Ras signaling pathway_Homo sapiens_hsa040140.60303204
121Fanconi anemia pathway_Homo sapiens_hsa034600.59775554
122Glioma_Homo sapiens_hsa052140.58727808
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57512177
124Morphine addiction_Homo sapiens_hsa050320.57351472
125Salmonella infection_Homo sapiens_hsa051320.56649091
126FoxO signaling pathway_Homo sapiens_hsa040680.56231487
127Thyroid hormone synthesis_Homo sapiens_hsa049180.56135750
128Ovarian steroidogenesis_Homo sapiens_hsa049130.55218306
129Tight junction_Homo sapiens_hsa045300.54424330
130Non-homologous end-joining_Homo sapiens_hsa034500.54386700
131Protein export_Homo sapiens_hsa030600.53913763
132Insulin secretion_Homo sapiens_hsa049110.53813721
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53210977
134Pancreatic cancer_Homo sapiens_hsa052120.53084720
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51574891
136Circadian entrainment_Homo sapiens_hsa047130.51275676
137Chronic myeloid leukemia_Homo sapiens_hsa052200.50843653
138Cardiac muscle contraction_Homo sapiens_hsa042600.50712058
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50330490
140Cell cycle_Homo sapiens_hsa041100.48786688
141cAMP signaling pathway_Homo sapiens_hsa040240.47221029
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.46219953

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