ZFHX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1head development (GO:0060322)5.53365980
2negative regulation of axon guidance (GO:1902668)5.48966385
3negative regulation of axon extension involved in axon guidance (GO:0048843)5.46450396
4response to pheromone (GO:0019236)5.07937840
5lateral sprouting from an epithelium (GO:0060601)5.01938188
6presynaptic membrane assembly (GO:0097105)4.89069717
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.87869800
8axon extension involved in axon guidance (GO:0048846)4.87869800
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85942894
10postsynaptic membrane organization (GO:0001941)4.79103466
11retinal ganglion cell axon guidance (GO:0031290)4.67095462
12nucleobase catabolic process (GO:0046113)4.64051843
13presynaptic membrane organization (GO:0097090)4.59073224
14regulation of axon guidance (GO:1902667)4.50493814
15embryonic cranial skeleton morphogenesis (GO:0048701)4.41500856
16craniofacial suture morphogenesis (GO:0097094)4.38741282
17regulation of axon extension involved in axon guidance (GO:0048841)4.35854544
18middle ear morphogenesis (GO:0042474)4.27945503
19embryonic body morphogenesis (GO:0010172)4.22452487
20negative chemotaxis (GO:0050919)4.22176549
21body morphogenesis (GO:0010171)4.20224133
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.17436537
23outer ear morphogenesis (GO:0042473)4.16101524
24mitotic sister chromatid cohesion (GO:0007064)4.16007827
25planar cell polarity pathway involved in neural tube closure (GO:0090179)4.11157736
26axonal fasciculation (GO:0007413)4.08141653
27behavioral response to nicotine (GO:0035095)4.06195385
28hippo signaling (GO:0035329)4.04786867
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.04263847
30metanephric mesenchyme development (GO:0072075)3.97524244
31neuron cell-cell adhesion (GO:0007158)3.87139471
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.81292675
33chondrocyte proliferation (GO:0035988)3.71774543
34kidney mesenchyme development (GO:0072074)3.66372017
35cranial suture morphogenesis (GO:0060363)3.64401173
36midgut development (GO:0007494)3.64008754
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.63954450
38limb bud formation (GO:0060174)3.59923583
39somite development (GO:0061053)3.59399761
40negative regulation of DNA repair (GO:0045738)3.59297802
41dendritic spine morphogenesis (GO:0060997)3.56359302
42cochlea morphogenesis (GO:0090103)3.55599339
43auditory behavior (GO:0031223)3.55129686
44bone trabecula formation (GO:0060346)3.54870939
45chondrocyte development (GO:0002063)3.54757826
46protein localization to synapse (GO:0035418)3.54279568
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52401815
48positive regulation of synapse assembly (GO:0051965)3.51358195
49positive regulation of mesenchymal cell proliferation (GO:0002053)3.50464652
50regulation of cardioblast proliferation (GO:0003264)3.47592432
51regulation of secondary heart field cardioblast proliferation (GO:0003266)3.47592432
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.45693790
53embryonic forelimb morphogenesis (GO:0035115)3.42671910
54negative regulation of catenin import into nucleus (GO:0035414)3.41987562
55embryonic hindlimb morphogenesis (GO:0035116)3.40309544
56regulation of mesenchymal cell proliferation (GO:0010464)3.39849548
57positive regulation of gastrulation (GO:2000543)3.38524308
58central nervous system projection neuron axonogenesis (GO:0021952)3.37297410
59cell migration involved in heart development (GO:0060973)3.35031990
60hindlimb morphogenesis (GO:0035137)3.34205618
61axon extension (GO:0048675)3.33437400
62cell proliferation in forebrain (GO:0021846)3.29325160
63glomerular filtration (GO:0003094)3.29124633
64positive regulation of catenin import into nucleus (GO:0035413)3.25157633
65convergent extension (GO:0060026)3.23918930
66regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.23259735
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.22606869
68cell migration in hindbrain (GO:0021535)3.22361370
69camera-type eye morphogenesis (GO:0048593)3.20677633
70mesenchyme morphogenesis (GO:0072132)3.20642069
71palate development (GO:0060021)3.17875833
72neuron recognition (GO:0008038)3.16809057
73regulation of heart morphogenesis (GO:2000826)3.15371169
74nonmotile primary cilium assembly (GO:0035058)3.14492125
75embryonic limb morphogenesis (GO:0030326)3.13263902
76embryonic appendage morphogenesis (GO:0035113)3.13263902
77neurotransmitter-gated ion channel clustering (GO:0072578)3.12967545
78endocardial cushion morphogenesis (GO:0003203)3.12613381
79mesenchymal-epithelial cell signaling (GO:0060638)3.12327303
80vocalization behavior (GO:0071625)3.11882743
81transmission of nerve impulse (GO:0019226)3.11544931
82appendage morphogenesis (GO:0035107)3.09770215
83limb morphogenesis (GO:0035108)3.09770215
84olfactory bulb development (GO:0021772)3.08869991
85regulation of establishment of planar polarity (GO:0090175)3.08419131
86intraciliary transport (GO:0042073)3.08301172
87Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.08136214
88phenol-containing compound catabolic process (GO:0019336)3.07998987
89sequestering of extracellular ligand from receptor (GO:0035581)3.07959497
90regulation of catenin import into nucleus (GO:0035412)3.07573297
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06124941
92negative regulation of chondrocyte differentiation (GO:0032331)3.05981510
93regulation of chemokine-mediated signaling pathway (GO:0070099)3.05166154
94cerebral cortex radially oriented cell migration (GO:0021799)3.05033734
95forelimb morphogenesis (GO:0035136)3.04845446
96protein polyglutamylation (GO:0018095)3.03172553
97epithelial cilium movement (GO:0003351)3.02898673
98spinal cord development (GO:0021510)3.01992232
99establishment of mitochondrion localization (GO:0051654)3.01576057
100mechanosensory behavior (GO:0007638)3.01433587
101short-term memory (GO:0007614)2.99366364
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99139714
103gastrulation with mouth forming second (GO:0001702)2.98795349
104synapse assembly (GO:0007416)2.97337457
105positive regulation of smoothened signaling pathway (GO:0045880)2.96484582
106proximal/distal pattern formation (GO:0009954)2.96419138
107embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95155185
108limb development (GO:0060173)2.94973497
109appendage development (GO:0048736)2.94973497
110dermatan sulfate biosynthetic process (GO:0030208)2.94377129
111negative regulation of axon extension (GO:0030517)2.94007127
112neurotransmitter catabolic process (GO:0042135)2.93435085
113dopaminergic neuron differentiation (GO:0071542)2.93204310
114interkinetic nuclear migration (GO:0022027)2.91396990
115spinal cord association neuron differentiation (GO:0021527)2.89939077
116establishment of nucleus localization (GO:0040023)2.86892522
117behavioral response to ethanol (GO:0048149)2.85039144
118central nervous system neuron axonogenesis (GO:0021955)2.83840545
119cranial nerve morphogenesis (GO:0021602)2.83659277
120dendrite morphogenesis (GO:0048813)2.83610015
121embryonic digit morphogenesis (GO:0042733)2.82264324
122thalamus development (GO:0021794)2.82110835
123calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81271057
124paraxial mesoderm development (GO:0048339)2.81112227
125eyelid development in camera-type eye (GO:0061029)2.80913689
126heart morphogenesis (GO:0003007)2.80541462
127renal filtration (GO:0097205)2.79962666
128dendrite development (GO:0016358)2.79495520
129glial cell migration (GO:0008347)2.76995343
130adult walking behavior (GO:0007628)2.76801437
131artery development (GO:0060840)2.75376318
132pyrimidine nucleobase catabolic process (GO:0006208)2.75040862
133tongue development (GO:0043586)2.74449515
134embryonic skeletal system morphogenesis (GO:0048704)2.74080448
135regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.73922283
136negative regulation of embryonic development (GO:0045992)2.73641336
137glucocorticoid receptor signaling pathway (GO:0042921)2.73567179
138epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72294037
139negative regulation of stem cell proliferation (GO:2000647)2.72096880
140nucleus localization (GO:0051647)2.71530899
141regulation of synapse assembly (GO:0051963)2.71279687
142cell proliferation involved in metanephros development (GO:0072203)2.70601509
143establishment of planar polarity (GO:0001736)2.68384561
144establishment of tissue polarity (GO:0007164)2.68384561
145neuron fate determination (GO:0048664)2.68164870
146neuron projection extension (GO:1990138)2.67878501
147ganglion development (GO:0061548)2.65500809
148neuronal ion channel clustering (GO:0045161)2.65223376
149neuron migration (GO:0001764)2.64049841
150cornea development in camera-type eye (GO:0061303)2.62784382
151substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.62755287
152substrate-independent telencephalic tangential migration (GO:0021826)2.62755287
153smoothened signaling pathway (GO:0007224)2.62429090
154neural tube formation (GO:0001841)2.61593560
155hindbrain development (GO:0030902)2.57361289
156gamma-aminobutyric acid transport (GO:0015812)2.57223552
157cilium movement (GO:0003341)2.55202252
158positive regulation of dendritic spine morphogenesis (GO:0061003)2.53963916
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.53293430
160protein localization to cilium (GO:0061512)2.52728446
161positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52694659
162sequestering of actin monomers (GO:0042989)2.52655027
163cell differentiation in spinal cord (GO:0021515)2.51406207
164response to auditory stimulus (GO:0010996)2.50332125
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49824902
166hippocampus development (GO:0021766)2.49488680
167regulation of synapse structural plasticity (GO:0051823)2.49479043
168establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48788913
169mitochondrion transport along microtubule (GO:0047497)2.48788913
170cilium assembly (GO:0042384)2.47280220
171neurofilament cytoskeleton organization (GO:0060052)2.46241832
172forebrain neuron differentiation (GO:0021879)2.44688944
173negative regulation of axonogenesis (GO:0050771)2.44679761
174cilium organization (GO:0044782)2.44566890
175regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43857977
176membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38249804
177negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.37701861
178negative regulation of translation, ncRNA-mediated (GO:0040033)2.37701861
179regulation of translation, ncRNA-mediated (GO:0045974)2.37701861
180positive regulation of embryonic development (GO:0040019)2.37622914
181cilium morphogenesis (GO:0060271)2.37541623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47857517
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.47569822
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.00058526
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.08611123
5* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02182896
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.85159042
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.68317637
8GBX2_23144817_ChIP-Seq_PC3_Human2.66869405
9* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55396297
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.49304093
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.31391255
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.29961550
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29805998
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29805998
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.28447312
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27076473
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24520029
18* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24108426
19* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20896043
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10433973
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05778370
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01344582
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.00496819
24* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94179429
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93559412
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89094315
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87312349
28REST_21632747_ChIP-Seq_MESCs_Mouse1.86371718
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85937874
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84772371
31FUS_26573619_Chip-Seq_HEK293_Human1.84404073
32* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83919536
33VDR_22108803_ChIP-Seq_LS180_Human1.82020868
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77358498
35TAF15_26573619_Chip-Seq_HEK293_Human1.76939377
36* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71828184
37EWS_26573619_Chip-Seq_HEK293_Human1.70592327
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68320945
39ZNF274_21170338_ChIP-Seq_K562_Hela1.67591915
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66197001
41AR_21572438_ChIP-Seq_LNCaP_Human1.63617544
42* P300_19829295_ChIP-Seq_ESCs_Human1.63284425
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56968376
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.52666300
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52144486
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.50527306
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50195308
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.50089912
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49396071
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49207799
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.49038641
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48407397
53* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46708724
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46212908
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.44193644
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.42670806
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42654896
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42329169
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40220073
60* RNF2_27304074_Chip-Seq_NSC_Mouse1.39953159
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38547298
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37719360
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37645026
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37456461
65TP53_18474530_ChIP-ChIP_U2OS_Human1.37006458
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36828380
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.36538271
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36265391
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.35660520
70* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33603636
71BCAT_22108803_ChIP-Seq_LS180_Human1.33488508
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.33098928
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32985378
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32566945
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32207653
76* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31205242
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27298616
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26698741
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26036682
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25404005
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22767882
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20175881
83CBP_20019798_ChIP-Seq_JUKART_Human1.18922582
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18922582
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18427516
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17763960
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17763960
88TP53_16413492_ChIP-PET_HCT116_Human1.16800242
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.16585025
90TCF4_23295773_ChIP-Seq_U87_Human1.15046868
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14534779
92ER_23166858_ChIP-Seq_MCF-7_Human1.14299802
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.14295641
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.14230672
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12950737
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12474456
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12438699
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.10699227
99* AR_25329375_ChIP-Seq_VCAP_Human1.09841824
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08923586
101* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08732100
102* AR_19668381_ChIP-Seq_PC3_Human1.08338414
103* STAT3_23295773_ChIP-Seq_U87_Human1.08329781
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08219842
105IRF1_19129219_ChIP-ChIP_H3396_Human1.08216577
106SOX9_26525672_Chip-Seq_HEART_Mouse1.07331394
107RUNX2_22187159_ChIP-Seq_PCA_Human1.07272016
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06665404
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.05910615
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.05350872
111AHR_22903824_ChIP-Seq_MCF-7_Human1.04532709
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04341989
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.03380079
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03046254
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.02409144
116* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02202760
117* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02202760
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02043213
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02029197
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00673192
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00548692
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00274103
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99108282
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98172078
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97642477
126DROSHA_22980978_ChIP-Seq_HELA_Human0.97520251
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97519830
128IGF1R_20145208_ChIP-Seq_DFB_Human0.96634767
129* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96105374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.86782126
2MP0010030_abnormal_orbit_morphology3.84349197
3MP0005503_abnormal_tendon_morphology3.43054746
4MP0009250_abnormal_appendicular_skeleto3.16196221
5MP0003385_abnormal_body_wall3.06250743
6MP0009053_abnormal_anal_canal2.85155925
7MP0000049_abnormal_middle_ear2.82023028
8MP0002938_white_spotting2.71057657
9MP0003942_abnormal_urinary_system2.68499360
10MP0003121_genomic_imprinting2.58300325
11MP0003937_abnormal_limbs/digits/tail_de2.51298477
12MP0000534_abnormal_ureter_morphology2.47051860
13MP0000566_synostosis2.43839517
14MP0003755_abnormal_palate_morphology2.37979694
15MP0008789_abnormal_olfactory_epithelium2.31312895
16MP0000569_abnormal_digit_pigmentation2.24473965
17MP0002102_abnormal_ear_morphology2.21059974
18MP0001529_abnormal_vocalization2.18864532
19MP0001299_abnormal_eye_distance/2.12165173
20MP0002233_abnormal_nose_morphology2.10327985
21MP0002249_abnormal_larynx_morphology2.05422539
22MP0008438_abnormal_cutaneous_collagen2.05351176
23MP0005187_abnormal_penis_morphology2.04378392
24MP0002822_catalepsy2.01162377
25MP0003935_abnormal_craniofacial_develop2.01071625
26MP0005248_abnormal_Harderian_gland1.95321826
27MP0005423_abnormal_somatic_nervous1.93283119
28MP0002932_abnormal_joint_morphology1.83459617
29MP0004133_heterotaxia1.78431654
30MP0000537_abnormal_urethra_morphology1.76928216
31MP0000762_abnormal_tongue_morphology1.73784857
32MP0000778_abnormal_nervous_system1.73525441
33MP0002116_abnormal_craniofacial_bone1.72937561
34MP0005171_absent_coat_pigmentation1.67019591
35MP0001293_anophthalmia1.64570517
36MP0003938_abnormal_ear_development1.64017749
37MP0001346_abnormal_lacrimal_gland1.63618090
38MP0002177_abnormal_outer_ear1.62953559
39MP0004270_analgesia1.62059888
40MP0003635_abnormal_synaptic_transmissio1.58700358
41MP0003123_paternal_imprinting1.56653856
42MP0000733_abnormal_muscle_development1.53384683
43MP0000428_abnormal_craniofacial_morphol1.52757153
44MP0000432_abnormal_head_morphology1.50459341
45MP0001270_distended_abdomen1.50133868
46MP0005394_taste/olfaction_phenotype1.48234443
47MP0005499_abnormal_olfactory_system1.48234443
48MP0002282_abnormal_trachea_morphology1.44804431
49MP0003890_abnormal_embryonic-extraembry1.44713733
50MP0001486_abnormal_startle_reflex1.44245217
51MP0002109_abnormal_limb_morphology1.44145971
52MP0003705_abnormal_hypodermis_morpholog1.43776591
53MP0003136_yellow_coat_color1.43257295
54MP0009697_abnormal_copulation1.42262953
55MP0009703_decreased_birth_body1.41512005
56MP0002063_abnormal_learning/memory/cond1.40721138
57MP0001984_abnormal_olfaction1.37209858
58MP0004885_abnormal_endolymph1.36512454
59MP0004742_abnormal_vestibular_system1.36062114
60MP0002734_abnormal_mechanical_nocicepti1.35289434
61MP0002752_abnormal_somatic_nervous1.34279291
62MP0002272_abnormal_nervous_system1.34088579
63MP0009384_cardiac_valve_regurgitation1.34042405
64MP0005508_abnormal_skeleton_morphology1.33647683
65MP0006276_abnormal_autonomic_nervous1.33211965
66MP0003283_abnormal_digestive_organ1.32572489
67MP0009745_abnormal_behavioral_response1.32305962
68MP0002735_abnormal_chemical_nociception1.31502178
69MP0002108_abnormal_muscle_morphology1.31002016
70MP0001340_abnormal_eyelid_morphology1.30955309
71MP0002572_abnormal_emotion/affect_behav1.29715283
72MP0000631_abnormal_neuroendocrine_gland1.29441525
73MP0003115_abnormal_respiratory_system1.29409460
74MP0005551_abnormal_eye_electrophysiolog1.28422977
75MP0000163_abnormal_cartilage_morphology1.26083331
76MP0004145_abnormal_muscle_electrophysio1.23192382
77MP0004142_abnormal_muscle_tone1.20446785
78MP0002638_abnormal_pupillary_reflex1.20256392
79MP0005275_abnormal_skin_tensile1.19407516
80MP0001485_abnormal_pinna_reflex1.19296813
81MP0002067_abnormal_sensory_capabilities1.19034864
82MP0003861_abnormal_nervous_system1.17306208
83MP0001968_abnormal_touch/_nociception1.16511507
84MP0001286_abnormal_eye_development1.14129927
85MP0002064_seizures1.13781728
86MP0009046_muscle_twitch1.13685299
87MP0002115_abnormal_skeleton_extremities1.13274316
88MP0002114_abnormal_axial_skeleton1.11304551
89MP0004811_abnormal_neuron_physiology1.08689336
90MP0005253_abnormal_eye_physiology1.06735355
91MP0001970_abnormal_pain_threshold1.03920316
92MP0005195_abnormal_posterior_eye1.03811766
93MP0004134_abnormal_chest_morphology1.03156538
94MP0006072_abnormal_retinal_apoptosis1.01472628
95MP0002733_abnormal_thermal_nociception1.01213641
96MP0000613_abnormal_salivary_gland1.00116354
97MP0005391_vision/eye_phenotype0.99836212
98MP0002081_perinatal_lethality0.98347886
99MP0001188_hyperpigmentation0.98224800
100MP0002092_abnormal_eye_morphology0.97178440
101MP0002736_abnormal_nociception_after0.96156784
102MP0002697_abnormal_eye_size0.95595857
103MP0004924_abnormal_behavior0.95203403
104MP0005386_behavior/neurological_phenoty0.95203403
105MP0002184_abnormal_innervation0.94087091
106MP0000516_abnormal_urinary_system0.93102789
107MP0005367_renal/urinary_system_phenotyp0.93102789
108MP0005076_abnormal_cell_differentiation0.92071456
109MP0008877_abnormal_DNA_methylation0.91779990
110MP0002113_abnormal_skeleton_development0.91069762
111MP0003880_abnormal_central_pattern0.89602615
112MP0002111_abnormal_tail_morphology0.88986690
113MP0002751_abnormal_autonomic_nervous0.88914407
114MP0003315_abnormal_perineum_morphology0.87520403
115MP0004272_abnormal_basement_membrane0.87379401
116MP0005257_abnormal_intraocular_pressure0.87099435
117MP0001963_abnormal_hearing_physiology0.86817242
118MP0009672_abnormal_birth_weight0.86574571
119MP0006292_abnormal_olfactory_placode0.85441978
120MP0002653_abnormal_ependyma_morphology0.84338349
121MP0002085_abnormal_embryonic_tissue0.83895223
122MP0002084_abnormal_developmental_patter0.83815501
123MP0001905_abnormal_dopamine_level0.83615592
124MP0002896_abnormal_bone_mineralization0.82771656
125MP0003119_abnormal_digestive_system0.82617741
126MP0001440_abnormal_grooming_behavior0.81165718
127MP0002152_abnormal_brain_morphology0.80155781
128MP0002928_abnormal_bile_duct0.78221366
129MP0003787_abnormal_imprinting0.77413525
130MP0001943_abnormal_respiration0.75254874
131MP0004197_abnormal_fetal_growth/weight/0.75028826
132MP0004859_abnormal_synaptic_plasticity0.74509227
133MP0000955_abnormal_spinal_cord0.73635192
134MP0002557_abnormal_social/conspecific_i0.70039679
135MP0003941_abnormal_skin_development0.69245623
136MP0000026_abnormal_inner_ear0.68501116
137MP0003567_abnormal_fetal_cardiomyocyte0.63993734
138MP0001324_abnormal_eye_pigmentation0.63790152
139MP0002925_abnormal_cardiovascular_devel0.63775326
140MP0009780_abnormal_chondrocyte_physiolo0.63108770
141MP0003279_aneurysm0.62752213
142MP0000579_abnormal_nail_morphology0.62573514
143MP0002882_abnormal_neuron_morphology0.62237501
144MP0002234_abnormal_pharynx_morphology0.61712541
145MP0010368_abnormal_lymphatic_system0.61211405

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)6.68228357
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.68228357
3Abnormality of the 4th metacarpal (HP:0010012)5.19759965
4Microglossia (HP:0000171)4.66508308
5Cutaneous finger syndactyly (HP:0010554)3.54479793
6Pancreatic fibrosis (HP:0100732)3.42569358
7Midline defect of the nose (HP:0004122)3.37197441
8Shallow orbits (HP:0000586)3.33546032
9Gait imbalance (HP:0002141)3.28094353
10True hermaphroditism (HP:0010459)3.24535297
11Nephronophthisis (HP:0000090)3.23283620
12Coronal craniosynostosis (HP:0004440)3.21988688
13Abnormality of midbrain morphology (HP:0002418)3.15412409
14Molar tooth sign on MRI (HP:0002419)3.15412409
15Abnormality of the parietal bone (HP:0002696)3.14268952
16Medial flaring of the eyebrow (HP:0010747)3.13254445
17Increased number of teeth (HP:0011069)3.05588049
18Cutaneous syndactyly (HP:0012725)3.04722754
19Limb dystonia (HP:0002451)3.04033071
20Pancreatic cysts (HP:0001737)2.96393057
21Drooling (HP:0002307)2.94296825
22Abnormality of the phalanges of the hallux (HP:0010057)2.91220348
23Myokymia (HP:0002411)2.90839974
24Turricephaly (HP:0000262)2.90779397
25Congenital primary aphakia (HP:0007707)2.88034474
26Trigonocephaly (HP:0000243)2.86515413
27Genital tract atresia (HP:0001827)2.83690975
28Syringomyelia (HP:0003396)2.76288431
29Spinal cord lesions (HP:0100561)2.76288431
30Vitreoretinal degeneration (HP:0000655)2.73739657
31Vaginal atresia (HP:0000148)2.73078354
32Hepatoblastoma (HP:0002884)2.72506368
33Lymphangioma (HP:0100764)2.71348094
34Nephrogenic diabetes insipidus (HP:0009806)2.69252921
35Chorioretinal atrophy (HP:0000533)2.68397667
36Abnormality of the renal medulla (HP:0100957)2.66391486
37Excessive salivation (HP:0003781)2.63236018
38Renal duplication (HP:0000075)2.62244520
39Narrow palate (HP:0000189)2.57464478
40Hyperventilation (HP:0002883)2.53809181
41Wide anterior fontanel (HP:0000260)2.52414680
42Abnormality of the nasolacrimal system (HP:0000614)2.51195466
43Wide cranial sutures (HP:0010537)2.50839365
44Rib fusion (HP:0000902)2.48751247
45Abnormality of abdominal situs (HP:0011620)2.47435279
46Abdominal situs inversus (HP:0003363)2.47435279
47Hypoplasia of the maxilla (HP:0000327)2.46930148
48Short clavicles (HP:0000894)2.44800804
49Anteriorly placed anus (HP:0001545)2.42308183
50Mesomelia (HP:0003027)2.41595384
51Tracheomalacia (HP:0002779)2.41349770
52Broad toe (HP:0001837)2.38098761
53Progressive cerebellar ataxia (HP:0002073)2.37875521
54Focal seizures (HP:0007359)2.37203294
55Polyphagia (HP:0002591)2.36162618
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.35063290
57Volvulus (HP:0002580)2.34829939
58Poor coordination (HP:0002370)2.34088614
59Aplasia/Hypoplasia of the clavicles (HP:0006710)2.32714597
60Chronic hepatic failure (HP:0100626)2.31416689
61Postaxial hand polydactyly (HP:0001162)2.31162173
62Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.30206388
63Postaxial foot polydactyly (HP:0001830)2.29481905
64Lissencephaly (HP:0001339)2.28636071
65Bell-shaped thorax (HP:0001591)2.27470887
66Short middle phalanx of the 5th finger (HP:0004220)2.27389761
67Focal motor seizures (HP:0011153)2.25770728
68Hypoplastic labia majora (HP:0000059)2.22902942
69Anencephaly (HP:0002323)2.22231686
70Cystic liver disease (HP:0006706)2.20145752
71Oligodactyly (hands) (HP:0001180)2.18553286
72Morphological abnormality of the middle ear (HP:0008609)2.18232557
73Optic nerve hypoplasia (HP:0000609)2.18188097
74Atresia of the external auditory canal (HP:0000413)2.17851724
75Macroorchidism (HP:0000053)2.16843421
76Renal hypoplasia (HP:0000089)2.16003128
77Protrusio acetabuli (HP:0003179)2.15694420
78Pachygyria (HP:0001302)2.14697208
79Sclerocornea (HP:0000647)2.14631043
80Narrow forehead (HP:0000341)2.12260315
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.10964925
82Specific learning disability (HP:0001328)2.10593757
83Broad-based gait (HP:0002136)2.08536246
84Septo-optic dysplasia (HP:0100842)2.07202895
85Retinal dysplasia (HP:0007973)2.05919401
86Buphthalmos (HP:0000557)2.05031082
87Cortical dysplasia (HP:0002539)2.04746814
88Sacral dimple (HP:0000960)2.03455021
89Short metatarsal (HP:0010743)2.02475451
90Preaxial hand polydactyly (HP:0001177)2.01117834
91Deviation of the hallux (HP:0010051)2.00562897
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00506977
93Absent eyebrow (HP:0002223)2.00346629
94Flat face (HP:0012368)1.99735092
95Abnormality of the labia majora (HP:0012881)1.99557060
96Broad thumb (HP:0011304)1.99211343
97Narrow nasal bridge (HP:0000446)1.98539737
98Downturned corners of mouth (HP:0002714)1.98379166
99Long eyelashes (HP:0000527)1.97479960
100Micropenis (HP:0000054)1.96208742
101Abnormality of the nasal septum (HP:0000419)1.95125283
102Abnormality of the 2nd finger (HP:0004100)1.95023406
103Occipital encephalocele (HP:0002085)1.94866411
104Shawl scrotum (HP:0000049)1.94527598
105Atonic seizures (HP:0010819)1.94328982
106Intellectual disability, moderate (HP:0002342)1.94009603
107Increased nuchal translucency (HP:0010880)1.94005553
108Aplasia/Hypoplasia of the lens (HP:0008063)1.93470094
109Supernumerary ribs (HP:0005815)1.91370029
110Hallux valgus (HP:0001822)1.90567171
111Myelomeningocele (HP:0002475)1.89623467
112Broad hallux (HP:0010055)1.89124805
113Anophthalmia (HP:0000528)1.89013920
114Broad metatarsal (HP:0001783)1.88773999
115Preaxial foot polydactyly (HP:0001841)1.88626810
116Renovascular hypertension (HP:0100817)1.87732066
117Infantile muscular hypotonia (HP:0008947)1.87190325
118Lip pit (HP:0100267)1.86601235
119Growth hormone deficiency (HP:0000824)1.86533853
120High anterior hairline (HP:0009890)1.85741387
121Exotropia (HP:0000577)1.85202311
122Abnormal hair whorl (HP:0010721)1.84982365
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84570585
124Obsessive-compulsive behavior (HP:0000722)1.84199045
125Broad foot (HP:0001769)1.84080875
126Bifid scrotum (HP:0000048)1.83901766
127Bifid tongue (HP:0010297)1.83689617
128Asymmetry of the thorax (HP:0001555)1.83150417
129Renal dysplasia (HP:0000110)1.82777345
130Broad long bones (HP:0005622)1.81635516
131Amblyopia (HP:0000646)1.81412254
132Broad phalanx (HP:0006009)1.80388459
133Abnormality of the labia minora (HP:0012880)1.79553262
134Wrist flexion contracture (HP:0001239)1.78827212
135Broad finger (HP:0001500)1.78649420
136Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78164167
137Hypoplasia of the brainstem (HP:0002365)1.78164167
138Febrile seizures (HP:0002373)1.78019617
139Tented upper lip vermilion (HP:0010804)1.77826510
140Labial hypoplasia (HP:0000066)1.77634137
141Abnormal ciliary motility (HP:0012262)1.77128453
142Abnormal respiratory epithelium morphology (HP:0012253)1.77004800
143Abnormal respiratory motile cilium morphology (HP:0005938)1.77004800
144Abnormality of the aortic arch (HP:0012303)1.76726508
145Abnormality of the right ventricle (HP:0001707)1.76466649
146Abnormality of the lower motor neuron (HP:0002366)1.76122415
147Epileptic encephalopathy (HP:0200134)1.76028102
148Type II lissencephaly (HP:0007260)1.75728746
149Hypoplastic ischia (HP:0003175)1.75497356
150Abnormality of the lacrimal duct (HP:0011481)1.75332805
151Short foot (HP:0001773)1.74375672
152Patellar dislocation (HP:0002999)1.72519811
153Abnormality of the diencephalon (HP:0010662)1.71984956
154Cerebellar dysplasia (HP:0007033)1.71408625
155Short philtrum (HP:0000322)1.70401992
156Broad phalanges of the hand (HP:0009768)1.69845453
157Oligodactyly (HP:0012165)1.69428260
158Papillary thyroid carcinoma (HP:0002895)1.68171373
159Microtia (HP:0008551)1.67820190
160Bladder diverticulum (HP:0000015)1.67713939
161Hip dysplasia (HP:0001385)1.67255285
162Decreased testicular size (HP:0008734)1.67002981
163Congenital hepatic fibrosis (HP:0002612)1.66776129
164Genetic anticipation (HP:0003743)1.65928541
165Vesicoureteral reflux (HP:0000076)1.65683116
166Patellar aplasia (HP:0006443)1.64679630
167Keratoconus (HP:0000563)1.64561828
168Increased corneal curvature (HP:0100692)1.64561828
169Nasolacrimal duct obstruction (HP:0000579)1.64519045
170Dandy-Walker malformation (HP:0001305)1.64497244
171Dialeptic seizures (HP:0011146)1.63749570
172Long nose (HP:0003189)1.63280401
173Abnormal respiratory motile cilium physiology (HP:0012261)1.62181903
174Agitation (HP:0000713)1.62115385
175Dental malocclusion (HP:0000689)1.61382425
176Urethral obstruction (HP:0000796)1.60649487
177Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.59834871
178Aqueductal stenosis (HP:0002410)1.59690120
179Limited hip movement (HP:0008800)1.59495480
180Limited elbow extension (HP:0001377)1.59466129
181Small hand (HP:0200055)1.59386613
182Tubulointerstitial abnormality (HP:0001969)1.58968412
183Supernumerary spleens (HP:0009799)1.58148997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.91854419
2LATS13.63095594
3EPHA33.30179622
4DDR23.12576927
5CAMK1G3.02750207
6ERBB32.92149371
7FGFR22.77329164
8CAMK1D2.64672303
9EPHB22.37899380
10SIK32.37237895
11SIK12.32269274
12MARK12.22588019
13PDGFRA2.18088058
14CDK121.87406223
15BRD41.72395446
16DYRK31.72186684
17MAP4K21.64986856
18KSR11.64332982
19BCR1.63860307
20LATS21.60160528
21TRIM281.59948711
22FGFR11.59256116
23ICK1.54941148
24MKNK11.54674814
25PNCK1.52755619
26WNK31.50733379
27CASK1.47841289
28DYRK21.41686438
29EPHA41.39176518
30NTRK21.38290420
31CSNK1A1L1.37366507
32PINK11.25344902
33ERBB21.24073187
34MAP3K41.23164489
35MINK11.16406361
36PAK31.15976839
37CSNK1G11.15478393
38WNK11.08177552
39FER1.08141347
40MAPK131.07215450
41SGK4941.03698663
42SGK2231.03698663
43SGK21.02361351
44CSNK1G31.01679590
45TYRO31.01302313
46CDC71.00754095
47CSNK1G21.00031605
48NTRK30.98056262
49SIK20.97894330
50DMPK0.96876230
51AKT30.96814357
52STK30.92457746
53CDC42BPA0.92080149
54PLK20.90979519
55MTOR0.90791945
56PLK30.90029759
57IRAK20.88262830
58NTRK10.87774971
59WNK40.86589306
60FRK0.86576461
61UHMK10.86556146
62MAP2K40.85627589
63PKN10.84674589
64SGK30.83985285
65ADRBK10.81773549
66BMPR1B0.79781787
67PDGFRB0.78586159
68ADRBK20.78484840
69TAF10.77186293
70CDK50.74754504
71RIPK10.73784400
72ROCK10.72117641
73INSRR0.71976912
74WEE10.71772800
75PHKG10.71182496
76PHKG20.71182496
77MAPK150.71041139
78NUAK10.68977149
79PTK20.68874315
80MAP3K90.64143159
81MKNK20.62389231
82FGFR30.62372877
83CDK10.60877360
84STK390.60242318
85CHEK20.59521853
86CAMK2A0.59049528
87MAPK100.59025459
88ATR0.58695994
89STK110.58486867
90CDK190.57887125
91MAPKAPK50.57130025
92MAP2K70.56883515
93STK160.56595680
94CSNK1E0.56291941
95TGFBR10.56021177
96MAPK80.55596817
97CDK60.54837931
98ATM0.54065526
99GRK10.53990016
100CDK150.53618209
101MARK20.51429199
102CDK11A0.50599940
103PLK40.50136262
104GSK3B0.49806238
105MAPK140.48519507
106ZAK0.48256299
107PRKCG0.47383447
108PAK60.47364300
109DYRK1B0.47322004
110CAMK40.47008781
111MAPK90.46794618
112CAMK10.45336025
113PRKG10.45262264
114TTN0.44663139
115PAK20.43889338
116DYRK1A0.43835636
117STK38L0.43513085
118CAMK2B0.43416715
119CDK180.43309416
120PRKACA0.43244477
121MUSK0.43189782
122PRKD30.42238007
123MAPK10.42101221
124PIK3CA0.42083789
125VRK10.42077027
126CDK140.41958074
127CDK30.40757410
128MELK0.40696524
129ROCK20.39279397
130SGK10.38929492
131AKT10.38690186
132PRKCZ0.38529074
133PRKACB0.37564487
134CDK20.37495010
135PRKCE0.37435135
136CHEK10.37284264
137PRKAA10.37149740
138BCKDK0.37008498
139OBSCN0.36098524
140OXSR10.35002566
141ACVR1B0.34086908

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.65759800
2Nitrogen metabolism_Homo sapiens_hsa009103.00407948
3Hedgehog signaling pathway_Homo sapiens_hsa043402.99248321
4Axon guidance_Homo sapiens_hsa043602.87787768
5Hippo signaling pathway_Homo sapiens_hsa043902.28315081
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.13941667
7Wnt signaling pathway_Homo sapiens_hsa043102.13648734
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89681779
9Lysine degradation_Homo sapiens_hsa003101.85411780
10Adherens junction_Homo sapiens_hsa045201.82299831
11TGF-beta signaling pathway_Homo sapiens_hsa043501.80048654
12Cardiac muscle contraction_Homo sapiens_hsa042601.79355759
13Melanogenesis_Homo sapiens_hsa049161.68830476
14Nicotine addiction_Homo sapiens_hsa050331.60326358
15Parkinsons disease_Homo sapiens_hsa050121.59935082
16Oxidative phosphorylation_Homo sapiens_hsa001901.59656876
17Steroid biosynthesis_Homo sapiens_hsa001001.56499709
18Protein export_Homo sapiens_hsa030601.52800669
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50421827
20MicroRNAs in cancer_Homo sapiens_hsa052061.49713112
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48072434
22Colorectal cancer_Homo sapiens_hsa052101.45439248
23Proteoglycans in cancer_Homo sapiens_hsa052051.44554057
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41441432
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32997022
26Dopaminergic synapse_Homo sapiens_hsa047281.32935274
27Olfactory transduction_Homo sapiens_hsa047401.29838023
28Cocaine addiction_Homo sapiens_hsa050301.29805453
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29161982
30Basal transcription factors_Homo sapiens_hsa030221.26383164
31Huntingtons disease_Homo sapiens_hsa050161.26377348
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24138444
33Prostate cancer_Homo sapiens_hsa052151.22534769
34Circadian entrainment_Homo sapiens_hsa047131.21907161
35Gap junction_Homo sapiens_hsa045401.20225812
36Renin secretion_Homo sapiens_hsa049241.19017564
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18945603
38GABAergic synapse_Homo sapiens_hsa047271.17519350
39Endometrial cancer_Homo sapiens_hsa052131.16109499
40Fanconi anemia pathway_Homo sapiens_hsa034601.10101598
41Butanoate metabolism_Homo sapiens_hsa006501.08964796
42Ovarian steroidogenesis_Homo sapiens_hsa049131.08200044
43Type II diabetes mellitus_Homo sapiens_hsa049301.08012913
44Glutamatergic synapse_Homo sapiens_hsa047241.06412562
45Propanoate metabolism_Homo sapiens_hsa006401.05246975
46GnRH signaling pathway_Homo sapiens_hsa049121.05118212
47Alzheimers disease_Homo sapiens_hsa050101.04093368
48Cholinergic synapse_Homo sapiens_hsa047251.03877842
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.02605040
50Pathways in cancer_Homo sapiens_hsa052001.02409427
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00074805
52Dilated cardiomyopathy_Homo sapiens_hsa054140.99194769
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99174137
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96404707
55Focal adhesion_Homo sapiens_hsa045100.94927914
56ECM-receptor interaction_Homo sapiens_hsa045120.94914605
57Linoleic acid metabolism_Homo sapiens_hsa005910.94872459
58Synaptic vesicle cycle_Homo sapiens_hsa047210.94315059
59Renal cell carcinoma_Homo sapiens_hsa052110.93684889
60Phototransduction_Homo sapiens_hsa047440.93331085
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93273002
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93076963
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89824386
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89732948
65Glioma_Homo sapiens_hsa052140.89647814
66ErbB signaling pathway_Homo sapiens_hsa040120.88740118
67Amphetamine addiction_Homo sapiens_hsa050310.87573353
68Long-term depression_Homo sapiens_hsa047300.86118233
69Serotonergic synapse_Homo sapiens_hsa047260.85741866
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85315194
71Melanoma_Homo sapiens_hsa052180.83924543
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83628425
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83137402
74Cell cycle_Homo sapiens_hsa041100.82447831
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82358659
76Tyrosine metabolism_Homo sapiens_hsa003500.81949993
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80985469
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80451171
79Dorso-ventral axis formation_Homo sapiens_hsa043200.79715430
80Morphine addiction_Homo sapiens_hsa050320.78406196
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77754816
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77263276
83Notch signaling pathway_Homo sapiens_hsa043300.76204559
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75404299
85Oocyte meiosis_Homo sapiens_hsa041140.73957823
86Viral myocarditis_Homo sapiens_hsa054160.72777102
87Estrogen signaling pathway_Homo sapiens_hsa049150.72072496
88Insulin secretion_Homo sapiens_hsa049110.72028479
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71657851
90Chronic myeloid leukemia_Homo sapiens_hsa052200.71401058
91Thyroid hormone synthesis_Homo sapiens_hsa049180.71345694
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71307824
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71288711
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70910175
95Circadian rhythm_Homo sapiens_hsa047100.70571482
96Rap1 signaling pathway_Homo sapiens_hsa040150.69944996
97Tight junction_Homo sapiens_hsa045300.69942058
98Long-term potentiation_Homo sapiens_hsa047200.69139576
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67706865
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67639637
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67522266
102Ether lipid metabolism_Homo sapiens_hsa005650.67288113
103Renin-angiotensin system_Homo sapiens_hsa046140.66714913
104AMPK signaling pathway_Homo sapiens_hsa041520.66248821
105Calcium signaling pathway_Homo sapiens_hsa040200.65922666
106mTOR signaling pathway_Homo sapiens_hsa041500.64338592
107MAPK signaling pathway_Homo sapiens_hsa040100.63772584
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62398882
109Salivary secretion_Homo sapiens_hsa049700.61750883
110cAMP signaling pathway_Homo sapiens_hsa040240.61621050
111Oxytocin signaling pathway_Homo sapiens_hsa049210.60538600
112RNA degradation_Homo sapiens_hsa030180.60361526
113Tryptophan metabolism_Homo sapiens_hsa003800.59811415
114HTLV-I infection_Homo sapiens_hsa051660.59282085
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58268988
116Choline metabolism in cancer_Homo sapiens_hsa052310.58204906
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58078698
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57217169
119Protein digestion and absorption_Homo sapiens_hsa049740.56776286
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.56750849
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56133235
122Alcoholism_Homo sapiens_hsa050340.54760368
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53828551
124FoxO signaling pathway_Homo sapiens_hsa040680.51912561
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.51873238
126Gastric acid secretion_Homo sapiens_hsa049710.51133777
127beta-Alanine metabolism_Homo sapiens_hsa004100.51087303
128Insulin signaling pathway_Homo sapiens_hsa049100.50845915
129Taste transduction_Homo sapiens_hsa047420.49706741
130Pancreatic cancer_Homo sapiens_hsa052120.48718754
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.48483658
132Retinol metabolism_Homo sapiens_hsa008300.48200432
133Ras signaling pathway_Homo sapiens_hsa040140.48021447
134Regulation of autophagy_Homo sapiens_hsa041400.45704781
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.42712011
136Peroxisome_Homo sapiens_hsa041460.41179707
137ABC transporters_Homo sapiens_hsa020100.38331494
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35670022
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35364396

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