

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | central nervous system myelination (GO:0022010) | 9.22712475 |
| 2 | axon ensheathment in central nervous system (GO:0032291) | 9.22712475 |
| 3 | fatty acid elongation (GO:0030497) | 6.30413092 |
| 4 | myelination (GO:0042552) | 5.55276874 |
| 5 | long-chain fatty acid biosynthetic process (GO:0042759) | 5.50071373 |
| 6 | axon ensheathment (GO:0008366) | 5.47617947 |
| 7 | ensheathment of neurons (GO:0007272) | 5.47617947 |
| 8 | behavioral response to nicotine (GO:0035095) | 5.20087060 |
| 9 | establishment of mitochondrion localization (GO:0051654) | 4.76204074 |
| 10 | negative regulation of neurotransmitter transport (GO:0051589) | 4.72181190 |
| 11 | negative regulation of neurotransmitter secretion (GO:0046929) | 4.63919456 |
| 12 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.58678931 |
| 13 | cholesterol biosynthetic process (GO:0006695) | 4.57537658 |
| 14 | presynaptic membrane organization (GO:0097090) | 4.48391213 |
| 15 | presynaptic membrane assembly (GO:0097105) | 4.22277102 |
| 16 | neuron cell-cell adhesion (GO:0007158) | 4.09652388 |
| 17 | sterol biosynthetic process (GO:0016126) | 4.05293465 |
| 18 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 4.03909723 |
| 19 | regulation of collateral sprouting (GO:0048670) | 3.90627235 |
| 20 | negative regulation of protein localization to cell surface (GO:2000009) | 3.86328229 |
| 21 | nucleobase catabolic process (GO:0046113) | 3.85555232 |
| 22 | isoprenoid biosynthetic process (GO:0008299) | 3.83016660 |
| 23 | gamma-aminobutyric acid transport (GO:0015812) | 3.82077350 |
| 24 | photoreceptor cell differentiation (GO:0046530) | 3.80616999 |
| 25 | eye photoreceptor cell differentiation (GO:0001754) | 3.80616999 |
| 26 | auditory behavior (GO:0031223) | 3.79595359 |
| 27 | neural tube formation (GO:0001841) | 3.77668449 |
| 28 | L-amino acid import (GO:0043092) | 3.76194839 |
| 29 | oligodendrocyte differentiation (GO:0048709) | 3.75633295 |
| 30 | mechanosensory behavior (GO:0007638) | 3.66605465 |
| 31 | fucose catabolic process (GO:0019317) | 3.64051150 |
| 32 | L-fucose metabolic process (GO:0042354) | 3.64051150 |
| 33 | L-fucose catabolic process (GO:0042355) | 3.64051150 |
| 34 | apical protein localization (GO:0045176) | 3.61649881 |
| 35 | nonmotile primary cilium assembly (GO:0035058) | 3.53929139 |
| 36 | glycerophospholipid catabolic process (GO:0046475) | 3.51486885 |
| 37 | epithelial cilium movement (GO:0003351) | 3.47212495 |
| 38 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.46813174 |
| 39 | positive regulation of action potential (GO:0045760) | 3.46429691 |
| 40 | transmission of nerve impulse (GO:0019226) | 3.43643703 |
| 41 | astrocyte development (GO:0014002) | 3.42869900 |
| 42 | substantia nigra development (GO:0021762) | 3.38103982 |
| 43 | neuronal action potential propagation (GO:0019227) | 3.36051817 |
| 44 | myelin maintenance (GO:0043217) | 3.28604589 |
| 45 | response to pheromone (GO:0019236) | 3.25201886 |
| 46 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 3.24490440 |
| 47 | neuron recognition (GO:0008038) | 3.23701477 |
| 48 | postsynaptic membrane organization (GO:0001941) | 3.22320265 |
| 49 | kidney morphogenesis (GO:0060993) | 3.22226640 |
| 50 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 3.21837236 |
| 51 | asymmetric protein localization (GO:0008105) | 3.15558276 |
| 52 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.13859146 |
| 53 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.12509789 |
| 54 | response to methylmercury (GO:0051597) | 3.11602390 |
| 55 | synaptic vesicle exocytosis (GO:0016079) | 3.09877028 |
| 56 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 3.07427135 |
| 57 | response to lipoprotein particle (GO:0055094) | 3.06036723 |
| 58 | regulation of cilium movement (GO:0003352) | 3.05301952 |
| 59 | axonal fasciculation (GO:0007413) | 3.04807363 |
| 60 | cilium movement (GO:0003341) | 3.04370155 |
| 61 | adult walking behavior (GO:0007628) | 3.03062562 |
| 62 | protein localization to synapse (GO:0035418) | 3.02530654 |
| 63 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 3.02062544 |
| 64 | protein localization to cilium (GO:0061512) | 3.01606401 |
| 65 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.00545117 |
| 66 | indolalkylamine metabolic process (GO:0006586) | 3.00201508 |
| 67 | limb bud formation (GO:0060174) | 2.99607233 |
| 68 | tryptophan catabolic process (GO:0006569) | 2.98572113 |
| 69 | indole-containing compound catabolic process (GO:0042436) | 2.98572113 |
| 70 | indolalkylamine catabolic process (GO:0046218) | 2.98572113 |
| 71 | protein polyglutamylation (GO:0018095) | 2.98558916 |
| 72 | axoneme assembly (GO:0035082) | 2.98127062 |
| 73 | neuronal ion channel clustering (GO:0045161) | 2.97045944 |
| 74 | negative regulation of axonogenesis (GO:0050771) | 2.96687867 |
| 75 | retinal cone cell development (GO:0046549) | 2.96422214 |
| 76 | startle response (GO:0001964) | 2.95326876 |
| 77 | cilium organization (GO:0044782) | 2.93741342 |
| 78 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.92991322 |
| 79 | cilium morphogenesis (GO:0060271) | 2.87378517 |
| 80 | cilium assembly (GO:0042384) | 2.87180156 |
| 81 | detection of light stimulus involved in visual perception (GO:0050908) | 2.83821573 |
| 82 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.83821573 |
| 83 | creatine metabolic process (GO:0006600) | 2.83156011 |
| 84 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.83146708 |
| 85 | mitochondrion transport along microtubule (GO:0047497) | 2.83146708 |
| 86 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.83065472 |
| 87 | regulation of action potential (GO:0098900) | 2.82044306 |
| 88 | behavioral response to ethanol (GO:0048149) | 2.81235832 |
| 89 | membrane tubulation (GO:0097320) | 2.81199775 |
| 90 | amino acid import (GO:0043090) | 2.81072460 |
| 91 | glutamate receptor signaling pathway (GO:0007215) | 2.80993750 |
| 92 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 2.80567727 |
| 93 | somite development (GO:0061053) | 2.80324960 |
| 94 | kynurenine metabolic process (GO:0070189) | 2.79918265 |
| 95 | neurotransmitter uptake (GO:0001504) | 2.78948294 |
| 96 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.78922096 |
| 97 | intraciliary transport (GO:0042073) | 2.78042901 |
| 98 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.77625293 |
| 99 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.77398123 |
| 100 | ER overload response (GO:0006983) | 2.77267786 |
| 101 | mannosylation (GO:0097502) | 2.76627343 |
| 102 | platelet dense granule organization (GO:0060155) | 2.75392096 |
| 103 | fatty-acyl-CoA metabolic process (GO:0035337) | 2.75326533 |
| 104 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.74545409 |
| 105 | dendritic spine morphogenesis (GO:0060997) | 2.74263306 |
| 106 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.72853712 |
| 107 | retinal ganglion cell axon guidance (GO:0031290) | 2.72398066 |
| 108 | protein palmitoylation (GO:0018345) | 2.72279225 |
| 109 | response to redox state (GO:0051775) | 2.70824816 |
| 110 | spinal cord motor neuron differentiation (GO:0021522) | 2.70160594 |
| 111 | neuronal action potential (GO:0019228) | 2.69361988 |
| 112 | response to auditory stimulus (GO:0010996) | 2.65891763 |
| 113 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.65834998 |
| 114 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.65805405 |
| 115 | cAMP catabolic process (GO:0006198) | 2.64492455 |
| 116 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.64257734 |
| 117 | reflex (GO:0060004) | 2.62434894 |
| 118 | tryptophan metabolic process (GO:0006568) | 2.62310471 |
| 119 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.61815067 |
| 120 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.61815067 |
| 121 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.61815067 |
| 122 | regulation of telomere maintenance (GO:0032204) | 2.61649296 |
| 123 | photoreceptor cell maintenance (GO:0045494) | 2.61562891 |
| 124 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.61272357 |
| 125 | amyloid precursor protein metabolic process (GO:0042982) | 2.61020830 |
| 126 | myelination in peripheral nervous system (GO:0022011) | 2.59931890 |
| 127 | peripheral nervous system axon ensheathment (GO:0032292) | 2.59931890 |
| 128 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.59481935 |
| 129 | negative regulation of synaptic transmission (GO:0050805) | 2.58326837 |
| 130 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.58000165 |
| 131 | membrane assembly (GO:0071709) | 2.57939248 |
| 132 | protein neddylation (GO:0045116) | 2.57455965 |
| 133 | regulation of glucokinase activity (GO:0033131) | 2.56959628 |
| 134 | regulation of hexokinase activity (GO:1903299) | 2.56959628 |
| 135 | inner ear receptor stereocilium organization (GO:0060122) | 2.56958578 |
| 136 | response to epinephrine (GO:0071871) | 2.56320244 |
| 137 | nerve growth factor signaling pathway (GO:0038180) | 2.55882806 |
| 138 | negative regulation of axon extension (GO:0030517) | 2.55824632 |
| 139 | synapse assembly (GO:0007416) | 2.55743079 |
| 140 | nucleotide transmembrane transport (GO:1901679) | 2.55026117 |
| 141 | negative regulation of telomere maintenance (GO:0032205) | 2.54996788 |
| 142 | primary amino compound metabolic process (GO:1901160) | 2.54561269 |
| 143 | neuron-neuron synaptic transmission (GO:0007270) | 2.54178633 |
| 144 | protein-cofactor linkage (GO:0018065) | 2.53645599 |
| 145 | neuron remodeling (GO:0016322) | 2.52924600 |
| 146 | vocalization behavior (GO:0071625) | 2.52830511 |
| 147 | regulation of catecholamine metabolic process (GO:0042069) | 2.52486144 |
| 148 | regulation of dopamine metabolic process (GO:0042053) | 2.52486144 |
| 149 | neural nucleus development (GO:0048857) | 2.51837977 |
| 150 | protein complex biogenesis (GO:0070271) | 2.51490631 |
| 151 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.51416762 |
| 152 | synaptic transmission, glutamatergic (GO:0035249) | 2.50081612 |
| 153 | synaptic vesicle maturation (GO:0016188) | 2.49880311 |
| 154 | synaptic transmission, cholinergic (GO:0007271) | 2.49730773 |
| 155 | positive regulation of synapse assembly (GO:0051965) | 2.49178298 |
| 156 | indole-containing compound metabolic process (GO:0042430) | 2.48730008 |
| 157 | membrane depolarization during action potential (GO:0086010) | 2.48352722 |
| 158 | glial cell development (GO:0021782) | 2.48024723 |
| 159 | response to catecholamine (GO:0071869) | 2.47702088 |
| 160 | response to monoamine (GO:0071867) | 2.47702088 |
| 161 | peripheral nervous system development (GO:0007422) | 2.47464118 |
| 162 | dendrite morphogenesis (GO:0048813) | 2.47209563 |
| 163 | Golgi to endosome transport (GO:0006895) | 2.47162578 |
| 164 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.46829408 |
| 165 | NADH dehydrogenase complex assembly (GO:0010257) | 2.46829408 |
| 166 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.46829408 |
| 167 | appendage development (GO:0048736) | 2.46487892 |
| 168 | limb development (GO:0060173) | 2.46487892 |
| 169 | cornea development in camera-type eye (GO:0061303) | 2.46174421 |
| 170 | dendrite development (GO:0016358) | 2.46108948 |
| 171 | spinal cord development (GO:0021510) | 2.46040679 |
| 172 | head development (GO:0060322) | 2.45929016 |
| 173 | axon development (GO:0061564) | 2.45329302 |
| 174 | negative regulation of mast cell activation (GO:0033004) | 2.45320801 |
| 175 | cerebellar granule cell differentiation (GO:0021707) | 2.45074041 |
| 176 | photoreceptor cell development (GO:0042461) | 2.44436524 |
| 177 | serotonin metabolic process (GO:0042428) | 2.42051398 |
| 178 | sulfation (GO:0051923) | 2.41726671 |
| 179 | cellular ketone body metabolic process (GO:0046950) | 2.40822391 |
| 180 | olfactory bulb development (GO:0021772) | 2.40412553 |
| 181 | glycosphingolipid biosynthetic process (GO:0006688) | 2.40249330 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.88299576 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.67255962 |
| 3 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.72819210 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.61417491 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.58248223 |
| 6 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 2.51599464 |
| 7 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.51360604 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.39187491 |
| 9 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.38327580 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.36108637 |
| 11 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.32169422 |
| 12 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.10805587 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.06339064 |
| 14 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.06339064 |
| 15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.05645350 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.05320111 |
| 17 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 2.04767625 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.04091635 |
| 19 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.03856909 |
| 20 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.01760718 |
| 21 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.01332599 |
| 22 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.00477670 |
| 23 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.99308979 |
| 24 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.98513702 |
| 25 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.97974001 |
| 26 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.96239458 |
| 27 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.95113736 |
| 28 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.94265058 |
| 29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.93049163 |
| 30 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.92636612 |
| 31 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.91160285 |
| 32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.89523933 |
| 33 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.84988252 |
| 34 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.81333046 |
| 35 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.77795402 |
| 36 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.77278192 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.77269083 |
| 38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.74696597 |
| 39 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.73789272 |
| 40 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.62472765 |
| 41 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.61169606 |
| 42 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.61150109 |
| 43 | FUS_26573619_Chip-Seq_HEK293_Human | 1.60898910 |
| 44 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.60271405 |
| 45 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.58813569 |
| 46 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.58785611 |
| 47 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.58647221 |
| 48 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.57424662 |
| 49 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.55758539 |
| 50 | * TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.55525105 |
| 51 | * POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.55525105 |
| 52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.55211393 |
| 53 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.51817266 |
| 54 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.50356398 |
| 55 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.50356398 |
| 56 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.46917342 |
| 57 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.45804169 |
| 58 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.44779717 |
| 59 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.44115715 |
| 60 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.42164179 |
| 61 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.41881040 |
| 62 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.41880952 |
| 63 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.40724740 |
| 64 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.39153145 |
| 65 | STAT3_23295773_ChIP-Seq_U87_Human | 1.34892910 |
| 66 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.31941269 |
| 67 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.31265814 |
| 68 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.29309419 |
| 69 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28601112 |
| 70 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.28449351 |
| 71 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.28141964 |
| 72 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.27323608 |
| 73 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26977137 |
| 74 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.26860214 |
| 75 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.25476457 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.24510026 |
| 77 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23751911 |
| 78 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.23597617 |
| 79 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.23535035 |
| 80 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.22734205 |
| 81 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.22224763 |
| 82 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.21800212 |
| 83 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.21785464 |
| 84 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.21283797 |
| 85 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.20565975 |
| 86 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.20537702 |
| 87 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.19988027 |
| 88 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.18892160 |
| 89 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.18550657 |
| 90 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.18524139 |
| 91 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.16036549 |
| 92 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.15989184 |
| 93 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.15389241 |
| 94 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.14884739 |
| 95 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.14438019 |
| 96 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.13947280 |
| 97 | TCF4_23295773_ChIP-Seq_U87_Human | 1.13423286 |
| 98 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.12856034 |
| 99 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.11756208 |
| 100 | AR_25329375_ChIP-Seq_VCAP_Human | 1.10342896 |
| 101 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.10182475 |
| 102 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.09920383 |
| 103 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.09832798 |
| 104 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.09633086 |
| 105 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.09110044 |
| 106 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.08797837 |
| 107 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.05664080 |
| 108 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.05173749 |
| 109 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.04933105 |
| 110 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04853795 |
| 111 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04710757 |
| 112 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04696091 |
| 113 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.04641331 |
| 114 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.04503530 |
| 115 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.02082593 |
| 116 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.01606120 |
| 117 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00567497 |
| 118 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00567497 |
| 119 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.00398657 |
| 120 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.00375478 |
| 121 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.00375478 |
| 122 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.00325215 |
| 123 | * ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.99711117 |
| 124 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.99164407 |
| 125 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.98552664 |
| 126 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.98441389 |
| 127 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.98002729 |
| 128 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.97166863 |
| 129 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97154008 |
| 130 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.96970457 |
| 131 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.96786045 |
| 132 | EWS_26573619_Chip-Seq_HEK293_Human | 0.95824405 |
| 133 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.94755507 |
| 134 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.94042901 |
| 135 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93145034 |
| 136 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93100481 |
| 137 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93100481 |
| 138 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.92958620 |
| 139 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.92827754 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.06439359 |
| 2 | MP0000920_abnormal_myelination | 4.03557074 |
| 3 | MP0004270_analgesia | 3.72285755 |
| 4 | MP0004859_abnormal_synaptic_plasticity | 3.48639904 |
| 5 | MP0001529_abnormal_vocalization | 3.38720030 |
| 6 | MP0003950_abnormal_plasma_membrane | 2.78324540 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.75193848 |
| 8 | MP0000569_abnormal_digit_pigmentation | 2.70368462 |
| 9 | MP0003635_abnormal_synaptic_transmissio | 2.65598293 |
| 10 | MP0002064_seizures | 2.62994751 |
| 11 | MP0001486_abnormal_startle_reflex | 2.62344334 |
| 12 | MP0002272_abnormal_nervous_system | 2.62311026 |
| 13 | MP0005409_darkened_coat_color | 2.55016697 |
| 14 | MP0003329_amyloid_beta_deposits | 2.43887865 |
| 15 | MP0001905_abnormal_dopamine_level | 2.36585462 |
| 16 | MP0009745_abnormal_behavioral_response | 2.30669022 |
| 17 | MP0000778_abnormal_nervous_system | 2.30136937 |
| 18 | MP0006292_abnormal_olfactory_placode | 2.20654704 |
| 19 | MP0003690_abnormal_glial_cell | 2.17298254 |
| 20 | MP0004142_abnormal_muscle_tone | 2.12020323 |
| 21 | MP0002102_abnormal_ear_morphology | 2.10502672 |
| 22 | MP0009046_muscle_twitch | 2.08517478 |
| 23 | MP0002063_abnormal_learning/memory/cond | 2.05377855 |
| 24 | MP0005423_abnormal_somatic_nervous | 2.04919341 |
| 25 | MP0002572_abnormal_emotion/affect_behav | 2.04118455 |
| 26 | MP0003136_yellow_coat_color | 2.02276002 |
| 27 | MP0002734_abnormal_mechanical_nocicepti | 1.99961763 |
| 28 | MP0004742_abnormal_vestibular_system | 1.96595014 |
| 29 | MP0003634_abnormal_glial_cell | 1.94994460 |
| 30 | MP0002638_abnormal_pupillary_reflex | 1.94823308 |
| 31 | MP0005171_absent_coat_pigmentation | 1.94775177 |
| 32 | MP0002653_abnormal_ependyma_morphology | 1.85834192 |
| 33 | MP0004133_heterotaxia | 1.82038161 |
| 34 | MP0004885_abnormal_endolymph | 1.79719250 |
| 35 | MP0001968_abnormal_touch/_nociception | 1.75068031 |
| 36 | MP0003121_genomic_imprinting | 1.73658721 |
| 37 | MP0005551_abnormal_eye_electrophysiolog | 1.72885812 |
| 38 | MP0008569_lethality_at_weaning | 1.65966154 |
| 39 | MP0002229_neurodegeneration | 1.65415024 |
| 40 | MP0005646_abnormal_pituitary_gland | 1.63054794 |
| 41 | MP0002067_abnormal_sensory_capabilities | 1.61690240 |
| 42 | MP0000955_abnormal_spinal_cord | 1.60605122 |
| 43 | MP0000566_synostosis | 1.59295158 |
| 44 | MP0004924_abnormal_behavior | 1.56107119 |
| 45 | MP0005386_behavior/neurological_phenoty | 1.56107119 |
| 46 | MP0003632_abnormal_nervous_system | 1.55577029 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.48819892 |
| 48 | MP0001485_abnormal_pinna_reflex | 1.46476165 |
| 49 | MP0001970_abnormal_pain_threshold | 1.43772399 |
| 50 | MP0002736_abnormal_nociception_after | 1.41836418 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.41699314 |
| 52 | MP0001440_abnormal_grooming_behavior | 1.41297051 |
| 53 | MP0002066_abnormal_motor_capabilities/c | 1.37329225 |
| 54 | MP0002733_abnormal_thermal_nociception | 1.35943143 |
| 55 | MP0001986_abnormal_taste_sensitivity | 1.35173024 |
| 56 | MP0004043_abnormal_pH_regulation | 1.34683562 |
| 57 | MP0005645_abnormal_hypothalamus_physiol | 1.34197428 |
| 58 | MP0003122_maternal_imprinting | 1.33066308 |
| 59 | MP0003631_nervous_system_phenotype | 1.31971081 |
| 60 | MP0004134_abnormal_chest_morphology | 1.31851523 |
| 61 | MP0003011_delayed_dark_adaptation | 1.30571563 |
| 62 | MP0008872_abnormal_physiological_respon | 1.30473652 |
| 63 | MP0000427_abnormal_hair_cycle | 1.29939998 |
| 64 | MP0002735_abnormal_chemical_nociception | 1.28784269 |
| 65 | MP0006276_abnormal_autonomic_nervous | 1.28661612 |
| 66 | MP0000462_abnormal_digestive_system | 1.26723399 |
| 67 | MP0008789_abnormal_olfactory_epithelium | 1.22265507 |
| 68 | MP0001293_anophthalmia | 1.19232934 |
| 69 | MP0003633_abnormal_nervous_system | 1.19212415 |
| 70 | MP0009780_abnormal_chondrocyte_physiolo | 1.18641995 |
| 71 | MP0005410_abnormal_fertilization | 1.18208146 |
| 72 | MP0002184_abnormal_innervation | 1.18076194 |
| 73 | MP0002822_catalepsy | 1.17345957 |
| 74 | MP0002928_abnormal_bile_duct | 1.16397326 |
| 75 | MP0005174_abnormal_tail_pigmentation | 1.16327665 |
| 76 | MP0006072_abnormal_retinal_apoptosis | 1.15822489 |
| 77 | MP0002557_abnormal_social/conspecific_i | 1.15620000 |
| 78 | MP0002751_abnormal_autonomic_nervous | 1.14381252 |
| 79 | MP0004145_abnormal_muscle_electrophysio | 1.12964740 |
| 80 | MP0003787_abnormal_imprinting | 1.11413266 |
| 81 | MP0000604_amyloidosis | 1.11072580 |
| 82 | MP0003119_abnormal_digestive_system | 1.10269958 |
| 83 | MP0002752_abnormal_somatic_nervous | 1.09678790 |
| 84 | MP0010678_abnormal_skin_adnexa | 1.09037092 |
| 85 | MP0005499_abnormal_olfactory_system | 1.07996988 |
| 86 | MP0005394_taste/olfaction_phenotype | 1.07996988 |
| 87 | MP0002909_abnormal_adrenal_gland | 1.07002591 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 1.06407937 |
| 89 | MP0000383_abnormal_hair_follicle | 1.05941191 |
| 90 | MP0002152_abnormal_brain_morphology | 1.04825681 |
| 91 | MP0008875_abnormal_xenobiotic_pharmacok | 1.04078191 |
| 92 | MP0001963_abnormal_hearing_physiology | 1.03986692 |
| 93 | MP0003646_muscle_fatigue | 1.03971287 |
| 94 | MP0001501_abnormal_sleep_pattern | 1.03794806 |
| 95 | MP0005084_abnormal_gallbladder_morpholo | 1.03750089 |
| 96 | MP0001502_abnormal_circadian_rhythm | 1.00261141 |
| 97 | MP0004147_increased_porphyrin_level | 0.97600326 |
| 98 | MP0004811_abnormal_neuron_physiology | 0.97254164 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.96914482 |
| 100 | MP0005377_hearing/vestibular/ear_phenot | 0.96858960 |
| 101 | MP0003878_abnormal_ear_physiology | 0.96858960 |
| 102 | MP0005195_abnormal_posterior_eye | 0.96588324 |
| 103 | MP0002160_abnormal_reproductive_system | 0.95314695 |
| 104 | MP0002876_abnormal_thyroid_physiology | 0.94227513 |
| 105 | MP0005253_abnormal_eye_physiology | 0.93616881 |
| 106 | MP0004381_abnormal_hair_follicle | 0.92871179 |
| 107 | MP0004215_abnormal_myocardial_fiber | 0.91496927 |
| 108 | MP0000751_myopathy | 0.89897967 |
| 109 | MP0002234_abnormal_pharynx_morphology | 0.89546128 |
| 110 | MP0001984_abnormal_olfaction | 0.89378341 |
| 111 | MP0005389_reproductive_system_phenotype | 0.88668405 |
| 112 | MP0005391_vision/eye_phenotype | 0.88652519 |
| 113 | MP0001177_atelectasis | 0.87236101 |
| 114 | MP0004036_abnormal_muscle_relaxation | 0.87055220 |
| 115 | MP0002233_abnormal_nose_morphology | 0.86985555 |
| 116 | MP0001919_abnormal_reproductive_system | 0.86316011 |
| 117 | MP0010386_abnormal_urinary_bladder | 0.83012964 |
| 118 | MP0001299_abnormal_eye_distance/ | 0.82605904 |
| 119 | MP0000049_abnormal_middle_ear | 0.81843275 |
| 120 | MP0005187_abnormal_penis_morphology | 0.81715913 |
| 121 | MP0000372_irregular_coat_pigmentation | 0.80812830 |
| 122 | MP0001346_abnormal_lacrimal_gland | 0.79288895 |
| 123 | MP0008260_abnormal_autophagy | 0.78908627 |
| 124 | MP0001188_hyperpigmentation | 0.78094899 |
| 125 | MP0002090_abnormal_vision | 0.77456140 |
| 126 | MP0000537_abnormal_urethra_morphology | 0.77051931 |
| 127 | MP0000026_abnormal_inner_ear | 0.76694283 |
| 128 | MP0000647_abnormal_sebaceous_gland | 0.75481272 |
| 129 | MP0005623_abnormal_meninges_morphology | 0.72372821 |
| 130 | MP0003938_abnormal_ear_development | 0.71203644 |
| 131 | MP0003195_calcinosis | 0.71141541 |
| 132 | MP0003937_abnormal_limbs/digits/tail_de | 0.67743294 |
| 133 | MP0002069_abnormal_eating/drinking_beha | 0.67356637 |
| 134 | MP0004085_abnormal_heartbeat | 0.66420238 |
| 135 | MP0002938_white_spotting | 0.64455634 |
| 136 | MP0001661_extended_life_span | 0.64067391 |
| 137 | MP0000747_muscle_weakness | 0.62052621 |
| 138 | MP0002837_dystrophic_cardiac_calcinosis | 0.60825719 |
| 139 | MP0003861_abnormal_nervous_system | 0.60605573 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 6.67867502 |
| 2 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 6.67867502 |
| 3 | Neurofibrillary tangles (HP:0002185) | 5.58487566 |
| 4 | Abnormality of the corticospinal tract (HP:0002492) | 5.22241221 |
| 5 | Parakeratosis (HP:0001036) | 4.42034011 |
| 6 | Pancreatic cysts (HP:0001737) | 4.35484130 |
| 7 | True hermaphroditism (HP:0010459) | 4.10366744 |
| 8 | Cerebral inclusion bodies (HP:0100314) | 4.08763603 |
| 9 | Pancreatic fibrosis (HP:0100732) | 4.07264979 |
| 10 | Molar tooth sign on MRI (HP:0002419) | 4.01674892 |
| 11 | Abnormality of midbrain morphology (HP:0002418) | 4.01674892 |
| 12 | Spastic gait (HP:0002064) | 3.80756838 |
| 13 | Supranuclear gaze palsy (HP:0000605) | 3.70554317 |
| 14 | Focal motor seizures (HP:0011153) | 3.63157725 |
| 15 | Nephronophthisis (HP:0000090) | 3.60013825 |
| 16 | Increased serum pyruvate (HP:0003542) | 3.56557287 |
| 17 | Abnormality of glycolysis (HP:0004366) | 3.56557287 |
| 18 | Myokymia (HP:0002411) | 3.28591062 |
| 19 | Retinal dysplasia (HP:0007973) | 3.26569460 |
| 20 | Termporal pattern (HP:0011008) | 3.22985495 |
| 21 | Insidious onset (HP:0003587) | 3.22985495 |
| 22 | Abnormality of the renal medulla (HP:0100957) | 3.19490612 |
| 23 | Pheochromocytoma (HP:0002666) | 3.19000190 |
| 24 | Peripheral hypomyelination (HP:0007182) | 3.12630524 |
| 25 | Scanning speech (HP:0002168) | 3.11673595 |
| 26 | Truncal ataxia (HP:0002078) | 3.10208517 |
| 27 | Sensory axonal neuropathy (HP:0003390) | 3.05526192 |
| 28 | Cerebral hypomyelination (HP:0006808) | 3.02033772 |
| 29 | Dysmetria (HP:0001310) | 3.00021446 |
| 30 | Epileptic encephalopathy (HP:0200134) | 2.97900232 |
| 31 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.97823057 |
| 32 | Abnormality of the renal cortex (HP:0011035) | 2.94890791 |
| 33 | Congenital primary aphakia (HP:0007707) | 2.93443505 |
| 34 | Congenital stationary night blindness (HP:0007642) | 2.85736580 |
| 35 | Chronic hepatic failure (HP:0100626) | 2.84164210 |
| 36 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.83614186 |
| 37 | Hyperventilation (HP:0002883) | 2.81680336 |
| 38 | Methylmalonic acidemia (HP:0002912) | 2.77474574 |
| 39 | Neuroendocrine neoplasm (HP:0100634) | 2.76600617 |
| 40 | Ankle clonus (HP:0011448) | 2.74182490 |
| 41 | Leukodystrophy (HP:0002415) | 2.72637036 |
| 42 | Cystic liver disease (HP:0006706) | 2.69550270 |
| 43 | Intention tremor (HP:0002080) | 2.65839606 |
| 44 | Akinesia (HP:0002304) | 2.65689332 |
| 45 | Nephrogenic diabetes insipidus (HP:0009806) | 2.65243194 |
| 46 | Lower limb muscle weakness (HP:0007340) | 2.64361270 |
| 47 | Lissencephaly (HP:0001339) | 2.60029703 |
| 48 | Acute necrotizing encephalopathy (HP:0006965) | 2.53088655 |
| 49 | Onion bulb formation (HP:0003383) | 2.52202240 |
| 50 | Clumsiness (HP:0002312) | 2.51073712 |
| 51 | Atonic seizures (HP:0010819) | 2.42454099 |
| 52 | Partial agenesis of the corpus callosum (HP:0001338) | 2.42185884 |
| 53 | Genetic anticipation (HP:0003743) | 2.42146916 |
| 54 | Febrile seizures (HP:0002373) | 2.41589422 |
| 55 | Sclerocornea (HP:0000647) | 2.41397383 |
| 56 | Anteriorly placed anus (HP:0001545) | 2.40886341 |
| 57 | Tubular atrophy (HP:0000092) | 2.38684176 |
| 58 | Alacrima (HP:0000522) | 2.38170372 |
| 59 | Bile duct proliferation (HP:0001408) | 2.37544696 |
| 60 | Abnormal biliary tract physiology (HP:0012439) | 2.37544696 |
| 61 | Absent/shortened dynein arms (HP:0200106) | 2.35231694 |
| 62 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.35231694 |
| 63 | Abolished electroretinogram (ERG) (HP:0000550) | 2.34957788 |
| 64 | Poor coordination (HP:0002370) | 2.30360127 |
| 65 | Abnormal drinking behavior (HP:0030082) | 2.27173971 |
| 66 | Polydipsia (HP:0001959) | 2.27173971 |
| 67 | Thickened helices (HP:0000391) | 2.27091732 |
| 68 | Anencephaly (HP:0002323) | 2.24089527 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.22365518 |
| 70 | Drooling (HP:0002307) | 2.22158711 |
| 71 | Focal seizures (HP:0007359) | 2.21196201 |
| 72 | Optic nerve hypoplasia (HP:0000609) | 2.20579803 |
| 73 | Inability to walk (HP:0002540) | 2.20513054 |
| 74 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.20104013 |
| 75 | Absent septum pellucidum (HP:0001331) | 2.19906267 |
| 76 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.19780849 |
| 77 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.19471667 |
| 78 | Hypoplastic pelvis (HP:0008839) | 2.19392380 |
| 79 | Myelomeningocele (HP:0002475) | 2.17315539 |
| 80 | Generalized myoclonic seizures (HP:0002123) | 2.16815675 |
| 81 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.16708947 |
| 82 | Cerebral hemorrhage (HP:0001342) | 2.16238142 |
| 83 | Renal cortical cysts (HP:0000803) | 2.15997332 |
| 84 | Hemiparesis (HP:0001269) | 2.15027366 |
| 85 | Pachygyria (HP:0001302) | 2.13495584 |
| 86 | Type II lissencephaly (HP:0007260) | 2.11995313 |
| 87 | Intestinal atresia (HP:0011100) | 2.11820062 |
| 88 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.11432273 |
| 89 | Urinary urgency (HP:0000012) | 2.11391088 |
| 90 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.11162838 |
| 91 | Humeroradial synostosis (HP:0003041) | 2.11038954 |
| 92 | Synostosis involving the elbow (HP:0003938) | 2.11038954 |
| 93 | Attenuation of retinal blood vessels (HP:0007843) | 2.10843439 |
| 94 | Protruding tongue (HP:0010808) | 2.09352426 |
| 95 | Abnormal ciliary motility (HP:0012262) | 2.09060048 |
| 96 | Progressive macrocephaly (HP:0004481) | 2.08831839 |
| 97 | Pendular nystagmus (HP:0012043) | 2.08425639 |
| 98 | Progressive cerebellar ataxia (HP:0002073) | 2.07879009 |
| 99 | Cerebellar dysplasia (HP:0007033) | 2.07463667 |
| 100 | Limb dystonia (HP:0002451) | 2.06447966 |
| 101 | Abnormal auditory evoked potentials (HP:0006958) | 2.06169560 |
| 102 | Congenital hepatic fibrosis (HP:0002612) | 2.06019489 |
| 103 | Broad-based gait (HP:0002136) | 2.05013052 |
| 104 | Large for gestational age (HP:0001520) | 2.04488424 |
| 105 | CNS hypomyelination (HP:0003429) | 2.04429250 |
| 106 | Volvulus (HP:0002580) | 2.03839075 |
| 107 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.03281454 |
| 108 | Abnormality of alanine metabolism (HP:0010916) | 2.03281454 |
| 109 | Hyperalaninemia (HP:0003348) | 2.03281454 |
| 110 | Postaxial foot polydactyly (HP:0001830) | 2.03106652 |
| 111 | Slow saccadic eye movements (HP:0000514) | 2.01971597 |
| 112 | Postaxial hand polydactyly (HP:0001162) | 2.01557713 |
| 113 | Agitation (HP:0000713) | 2.01518610 |
| 114 | Excessive salivation (HP:0003781) | 2.00611097 |
| 115 | Dysdiadochokinesis (HP:0002075) | 2.00368561 |
| 116 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.00034497 |
| 117 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.99727681 |
| 118 | Aplasia of the phalanges of the hand (HP:0009802) | 1.99727681 |
| 119 | Aplasia involving bones of the extremities (HP:0009825) | 1.99727681 |
| 120 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.99721538 |
| 121 | Stridor (HP:0010307) | 1.99603929 |
| 122 | Acute encephalopathy (HP:0006846) | 1.99503175 |
| 123 | Abnormality of the septum pellucidum (HP:0007375) | 1.98877771 |
| 124 | Autoamputation (HP:0001218) | 1.98170518 |
| 125 | Male pseudohermaphroditism (HP:0000037) | 1.97630955 |
| 126 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.97335043 |
| 127 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.97335043 |
| 128 | Decreased lacrimation (HP:0000633) | 1.95338638 |
| 129 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.94987175 |
| 130 | Mitochondrial inheritance (HP:0001427) | 1.94231605 |
| 131 | Septo-optic dysplasia (HP:0100842) | 1.93804998 |
| 132 | Specific learning disability (HP:0001328) | 1.93647792 |
| 133 | Vaginal atresia (HP:0000148) | 1.93529666 |
| 134 | Furrowed tongue (HP:0000221) | 1.93112135 |
| 135 | Postnatal microcephaly (HP:0005484) | 1.93097898 |
| 136 | Hypothermia (HP:0002045) | 1.92585072 |
| 137 | Megalencephaly (HP:0001355) | 1.92045141 |
| 138 | Progressive inability to walk (HP:0002505) | 1.91871874 |
| 139 | Renal Fanconi syndrome (HP:0001994) | 1.91080603 |
| 140 | 3-Methylglutaconic aciduria (HP:0003535) | 1.90854189 |
| 141 | Narrow forehead (HP:0000341) | 1.90047990 |
| 142 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89627346 |
| 143 | Oligodactyly (hands) (HP:0001180) | 1.89246113 |
| 144 | Gait imbalance (HP:0002141) | 1.89186401 |
| 145 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.87497714 |
| 146 | Genital tract atresia (HP:0001827) | 1.87184429 |
| 147 | Gaze-evoked nystagmus (HP:0000640) | 1.86566530 |
| 148 | Polyuria (HP:0000103) | 1.86215542 |
| 149 | Colon cancer (HP:0003003) | 1.84441616 |
| 150 | Anophthalmia (HP:0000528) | 1.83810802 |
| 151 | Clonus (HP:0002169) | 1.83800235 |
| 152 | Occipital encephalocele (HP:0002085) | 1.83047455 |
| 153 | Optic disc pallor (HP:0000543) | 1.81914321 |
| 154 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.80506445 |
| 155 | Increased corneal curvature (HP:0100692) | 1.80380291 |
| 156 | Keratoconus (HP:0000563) | 1.80380291 |
| 157 | Blue irides (HP:0000635) | 1.79818622 |
| 158 | Polyphagia (HP:0002591) | 1.79728606 |
| 159 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.79498443 |
| 160 | Medial flaring of the eyebrow (HP:0010747) | 1.79470949 |
| 161 | Steppage gait (HP:0003376) | 1.79076793 |
| 162 | Premature skin wrinkling (HP:0100678) | 1.78695137 |
| 163 | Split foot (HP:0001839) | 1.78603718 |
| 164 | Fair hair (HP:0002286) | 1.78449827 |
| 165 | Increased circulating renin level (HP:0000848) | 1.78159745 |
| 166 | Cupped ear (HP:0000378) | 1.77435580 |
| 167 | Supernumerary spleens (HP:0009799) | 1.77133286 |
| 168 | Widely spaced teeth (HP:0000687) | 1.76821387 |
| 169 | Preaxial hand polydactyly (HP:0001177) | 1.75393727 |
| 170 | Spastic paraplegia (HP:0001258) | 1.75224407 |
| 171 | Esophageal atresia (HP:0002032) | 1.74584185 |
| 172 | Stomach cancer (HP:0012126) | 1.74356240 |
| 173 | Neuronal loss in central nervous system (HP:0002529) | 1.73796828 |
| 174 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.73112661 |
| 175 | Dandy-Walker malformation (HP:0001305) | 1.73017765 |
| 176 | Paraplegia (HP:0010550) | 1.72102880 |
| 177 | Anxiety (HP:0000739) | 1.71539906 |
| 178 | Patellar aplasia (HP:0006443) | 1.71329314 |
| 179 | Dialeptic seizures (HP:0011146) | 1.69960902 |
| 180 | Absent speech (HP:0001344) | 1.69492736 |
| 181 | Abnormal hair whorl (HP:0010721) | 1.68509528 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 4.94817150 |
| 2 | STK39 | 4.51216897 |
| 3 | OXSR1 | 3.62336084 |
| 4 | CASK | 2.98849728 |
| 5 | EPHB1 | 2.75110862 |
| 6 | MAP4K2 | 2.62928059 |
| 7 | BCR | 2.61093268 |
| 8 | UHMK1 | 2.53462223 |
| 9 | PKN1 | 2.35392229 |
| 10 | MARK1 | 2.28404762 |
| 11 | ADRBK2 | 2.26698836 |
| 12 | TNIK | 2.24255807 |
| 13 | PINK1 | 2.16685827 |
| 14 | CDK19 | 2.15134132 |
| 15 | ACVR1B | 2.08395395 |
| 16 | ZAK | 2.05181834 |
| 17 | PNCK | 1.99849543 |
| 18 | GRK1 | 1.88281901 |
| 19 | NUAK1 | 1.85352218 |
| 20 | MAPKAPK5 | 1.77953398 |
| 21 | WNK4 | 1.76289572 |
| 22 | CSNK1G3 | 1.68410947 |
| 23 | CAMK2B | 1.67745092 |
| 24 | MKNK2 | 1.66005810 |
| 25 | CSNK1A1L | 1.59728104 |
| 26 | SGK223 | 1.59702480 |
| 27 | SGK494 | 1.59702480 |
| 28 | EPHA4 | 1.59128056 |
| 29 | FGFR2 | 1.58948961 |
| 30 | NTRK2 | 1.58876154 |
| 31 | INSRR | 1.55478331 |
| 32 | LIMK1 | 1.50895684 |
| 33 | TAOK3 | 1.44539685 |
| 34 | CSNK1G2 | 1.44180528 |
| 35 | PRPF4B | 1.42317361 |
| 36 | ROCK2 | 1.41182069 |
| 37 | MET | 1.40963990 |
| 38 | WNK1 | 1.39994446 |
| 39 | CLK1 | 1.38358297 |
| 40 | PAK6 | 1.37363357 |
| 41 | NTRK3 | 1.37055460 |
| 42 | CAMKK2 | 1.34560636 |
| 43 | CSNK1G1 | 1.30849983 |
| 44 | DYRK2 | 1.29953527 |
| 45 | PBK | 1.28643539 |
| 46 | MAPK13 | 1.26657520 |
| 47 | MAPK15 | 1.24791631 |
| 48 | NEK6 | 1.22630292 |
| 49 | TIE1 | 1.22485569 |
| 50 | CAMK2D | 1.20432767 |
| 51 | NTRK1 | 1.19525128 |
| 52 | PAK3 | 1.11098784 |
| 53 | MUSK | 1.09263283 |
| 54 | CAMK2A | 1.09232704 |
| 55 | TLK1 | 1.08971025 |
| 56 | WNK3 | 1.07754770 |
| 57 | MAP2K7 | 1.06970133 |
| 58 | CDK5 | 1.06936462 |
| 59 | TGFBR1 | 1.05138464 |
| 60 | PHKG2 | 1.03477833 |
| 61 | PHKG1 | 1.03477833 |
| 62 | MARK2 | 1.03257574 |
| 63 | FGR | 1.02576790 |
| 64 | TRIM28 | 0.99895633 |
| 65 | MKNK1 | 0.98945989 |
| 66 | STK38L | 0.96018136 |
| 67 | CAMK2G | 0.94804910 |
| 68 | MST4 | 0.90513604 |
| 69 | BMPR1B | 0.88831539 |
| 70 | MAP3K4 | 0.88623950 |
| 71 | TYRO3 | 0.87665348 |
| 72 | PRKCE | 0.86487320 |
| 73 | MELK | 0.85620547 |
| 74 | TNK2 | 0.85022507 |
| 75 | SGK2 | 0.84138480 |
| 76 | ERBB3 | 0.83717671 |
| 77 | MINK1 | 0.82696384 |
| 78 | MAP2K4 | 0.80958103 |
| 79 | ADRBK1 | 0.80956834 |
| 80 | CAMK1G | 0.79094964 |
| 81 | CDK14 | 0.77862530 |
| 82 | TXK | 0.73343266 |
| 83 | GRK7 | 0.73290198 |
| 84 | PRKD1 | 0.70548699 |
| 85 | HIPK2 | 0.69902046 |
| 86 | PRKG1 | 0.69225772 |
| 87 | CDK15 | 0.67334011 |
| 88 | CDK18 | 0.67096034 |
| 89 | BMPR2 | 0.66014779 |
| 90 | VRK1 | 0.64855205 |
| 91 | PRKCQ | 0.63095289 |
| 92 | ICK | 0.62372642 |
| 93 | PLK2 | 0.61969133 |
| 94 | DYRK1A | 0.61102674 |
| 95 | FES | 0.60989533 |
| 96 | DYRK3 | 0.58376868 |
| 97 | CAMK1 | 0.57865977 |
| 98 | CDK11A | 0.56845033 |
| 99 | PRKCH | 0.56224700 |
| 100 | TESK2 | 0.55544888 |
| 101 | EIF2AK3 | 0.53936934 |
| 102 | IRAK1 | 0.52719176 |
| 103 | FYN | 0.52329175 |
| 104 | OBSCN | 0.51973963 |
| 105 | TEC | 0.51299344 |
| 106 | DMPK | 0.50895643 |
| 107 | PRKCZ | 0.50661444 |
| 108 | EPHA3 | 0.48889705 |
| 109 | MAP3K9 | 0.48543684 |
| 110 | BRSK2 | 0.47693154 |
| 111 | PRKCG | 0.47515437 |
| 112 | ERBB4 | 0.46078864 |
| 113 | SIK2 | 0.45163030 |
| 114 | PRKACB | 0.45000045 |
| 115 | STK11 | 0.44571681 |
| 116 | GSK3A | 0.44193436 |
| 117 | PTK2B | 0.43864767 |
| 118 | NLK | 0.43762928 |
| 119 | CAMKK1 | 0.43580368 |
| 120 | GRK5 | 0.43265601 |
| 121 | CSNK1A1 | 0.42633385 |
| 122 | PRKACA | 0.41927811 |
| 123 | SGK1 | 0.41822302 |
| 124 | STK16 | 0.41124393 |
| 125 | EPHB2 | 0.40514370 |
| 126 | PDGFRB | 0.40385335 |
| 127 | ARAF | 0.40237531 |
| 128 | RPS6KA5 | 0.39801480 |
| 129 | PIK3CA | 0.38859683 |
| 130 | PLK3 | 0.38846408 |
| 131 | CAMK4 | 0.38718168 |
| 132 | IRAK2 | 0.38420924 |
| 133 | AKT3 | 0.38193744 |
| 134 | ERBB2 | 0.37775330 |
| 135 | CDK3 | 0.37038241 |
| 136 | CAMK1D | 0.36550464 |
| 137 | CSNK1D | 0.36415400 |
| 138 | DAPK2 | 0.36089758 |
| 139 | BCKDK | 0.35608027 |
| 140 | PLK4 | 0.34819133 |
| 141 | BRD4 | 0.34632931 |
| 142 | MAPK10 | 0.34026277 |
| 143 | SRPK1 | 0.33710151 |
| 144 | ATM | 0.29329857 |
| 145 | NME1 | 0.27719724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 4.83291244 |
| 2 | Steroid biosynthesis_Homo sapiens_hsa00100 | 3.90023730 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.69617141 |
| 4 | Fatty acid elongation_Homo sapiens_hsa00062 | 3.33001490 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.38680931 |
| 6 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.33135938 |
| 7 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.32795340 |
| 8 | Nicotine addiction_Homo sapiens_hsa05033 | 2.22500424 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.16028968 |
| 10 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.12117975 |
| 11 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.04801656 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.03821508 |
| 13 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.98576012 |
| 14 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.97327280 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 1.94022597 |
| 16 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.90319383 |
| 17 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.84700387 |
| 18 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.81333256 |
| 19 | Morphine addiction_Homo sapiens_hsa05032 | 1.79283396 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.77492427 |
| 21 | Axon guidance_Homo sapiens_hsa04360 | 1.76358649 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75137516 |
| 23 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.71183900 |
| 24 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.71065105 |
| 25 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.66463505 |
| 26 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.66196479 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.60178755 |
| 28 | Circadian entrainment_Homo sapiens_hsa04713 | 1.53795898 |
| 29 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.48583525 |
| 30 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.47215176 |
| 31 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.45832622 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.45473222 |
| 33 | Long-term depression_Homo sapiens_hsa04730 | 1.42605381 |
| 34 | Protein export_Homo sapiens_hsa03060 | 1.41805156 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.36539137 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.36529302 |
| 37 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.33116566 |
| 38 | RNA polymerase_Homo sapiens_hsa03020 | 1.28849869 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.28562868 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 1.27124029 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.20976715 |
| 42 | Cocaine addiction_Homo sapiens_hsa05030 | 1.20266110 |
| 43 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.19655936 |
| 44 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.15555701 |
| 45 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.14124210 |
| 46 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.12276358 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.11977301 |
| 48 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.10160395 |
| 49 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.09999186 |
| 50 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.09296624 |
| 51 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.08797227 |
| 52 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.08660720 |
| 53 | Renin secretion_Homo sapiens_hsa04924 | 1.06807447 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 1.06022029 |
| 55 | Salivary secretion_Homo sapiens_hsa04970 | 1.05805928 |
| 56 | ABC transporters_Homo sapiens_hsa02010 | 1.04585886 |
| 57 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.04168257 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.04078363 |
| 59 | Taste transduction_Homo sapiens_hsa04742 | 1.01481633 |
| 60 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.01222746 |
| 61 | Long-term potentiation_Homo sapiens_hsa04720 | 1.00940299 |
| 62 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.99626461 |
| 63 | Homologous recombination_Homo sapiens_hsa03440 | 0.98056049 |
| 64 | Huntingtons disease_Homo sapiens_hsa05016 | 0.95049225 |
| 65 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.94837999 |
| 66 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.94712114 |
| 67 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.93626392 |
| 68 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.93605467 |
| 69 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.93463428 |
| 70 | Circadian rhythm_Homo sapiens_hsa04710 | 0.88069611 |
| 71 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.87140735 |
| 72 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.86946279 |
| 73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.86333790 |
| 74 | Olfactory transduction_Homo sapiens_hsa04740 | 0.86123426 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.84337379 |
| 76 | Insulin secretion_Homo sapiens_hsa04911 | 0.84187309 |
| 77 | Histidine metabolism_Homo sapiens_hsa00340 | 0.80910979 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.80531520 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.77030824 |
| 80 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77026556 |
| 81 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.73687251 |
| 82 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.72646321 |
| 83 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72635209 |
| 84 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.68344629 |
| 85 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.66493329 |
| 86 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.65444879 |
| 87 | Gap junction_Homo sapiens_hsa04540 | 0.65248137 |
| 88 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.61009171 |
| 89 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.60816970 |
| 90 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.60289247 |
| 91 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59915344 |
| 92 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.59093707 |
| 93 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.58647460 |
| 94 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.57433680 |
| 95 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.57298044 |
| 96 | Tight junction_Homo sapiens_hsa04530 | 0.57235007 |
| 97 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.56203767 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.55768599 |
| 99 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.55584310 |
| 100 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.54101092 |
| 101 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.53825753 |
| 102 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53652428 |
| 103 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.49698906 |
| 104 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.49357559 |
| 105 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48681019 |
| 106 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48351020 |
| 107 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45868037 |
| 108 | Endocytosis_Homo sapiens_hsa04144 | 0.45749194 |
| 109 | Melanogenesis_Homo sapiens_hsa04916 | 0.44785812 |
| 110 | Metabolic pathways_Homo sapiens_hsa01100 | 0.42764825 |
| 111 | Phagosome_Homo sapiens_hsa04145 | 0.42484340 |
| 112 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.42182801 |
| 113 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.41405948 |
| 114 | Alcoholism_Homo sapiens_hsa05034 | 0.41171129 |
| 115 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.40804067 |
| 116 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.40666886 |
| 117 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.40505861 |
| 118 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.39890932 |
| 119 | Purine metabolism_Homo sapiens_hsa00230 | 0.38827451 |
| 120 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.38097896 |
| 121 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.37824395 |
| 122 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.37646554 |
| 123 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.36618544 |
| 124 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.34565214 |
| 125 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.34536977 |
| 126 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33237269 |
| 127 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.33225335 |
| 128 | Ribosome_Homo sapiens_hsa03010 | 0.33104053 |
| 129 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.32343759 |
| 130 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.31887881 |
| 131 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30498285 |
| 132 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.30342422 |
| 133 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.30016601 |
| 134 | Lysine degradation_Homo sapiens_hsa00310 | 0.29817318 |
| 135 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.28973265 |
| 136 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.28384474 |
| 137 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.28358702 |
| 138 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.28353935 |
| 139 | Prion diseases_Homo sapiens_hsa05020 | 0.28080958 |
| 140 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.27872929 |
| 141 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27325208 |
| 142 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.26433021 |

