ZFP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell tolerance induction (GO:0002664)5.23990723
2detection of molecule of bacterial origin (GO:0032490)4.91569494
3presynaptic membrane assembly (GO:0097105)4.33634453
4presynaptic membrane organization (GO:0097090)4.11760997
5establishment of mitochondrion localization (GO:0051654)4.08573818
6interferon-gamma production (GO:0032609)3.97018708
7pyrimidine nucleobase catabolic process (GO:0006208)3.91200012
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85425288
9neuron cell-cell adhesion (GO:0007158)3.82407490
10dopaminergic neuron differentiation (GO:0071542)3.77793445
11positive regulation of mitochondrial fission (GO:0090141)3.76187088
12calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.74580509
13neuron recognition (GO:0008038)3.72848001
14lipopolysaccharide biosynthetic process (GO:0009103)3.70429447
15postsynaptic membrane organization (GO:0001941)3.67261481
16regulation of tolerance induction (GO:0002643)3.66515570
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64932217
18synapse assembly (GO:0007416)3.62105640
19regulation of glucokinase activity (GO:0033131)3.57132477
20regulation of hexokinase activity (GO:1903299)3.57132477
21protein localization to synapse (GO:0035418)3.56057844
22modulation by symbiont of host immune response (GO:0052553)3.55164639
23positive regulation by symbiont of host defense response (GO:0052509)3.55164639
24modulation by symbiont of host defense response (GO:0052031)3.55164639
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55164639
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55164639
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.55164639
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52470493
29nonmotile primary cilium assembly (GO:0035058)3.52246418
30histone H4-K12 acetylation (GO:0043983)3.48338228
31vocalization behavior (GO:0071625)3.46665625
32inner ear receptor cell development (GO:0060119)3.46080030
33positive regulation of tolerance induction (GO:0002645)3.45283544
34detection of external biotic stimulus (GO:0098581)3.41825852
35neurotransmitter-gated ion channel clustering (GO:0072578)3.40320504
36response to pheromone (GO:0019236)3.37228620
37histone H4-K5 acetylation (GO:0043981)3.34845958
38histone H4-K8 acetylation (GO:0043982)3.34845958
39retinal ganglion cell axon guidance (GO:0031290)3.32097032
40glycosphingolipid biosynthetic process (GO:0006688)3.31186721
41regulation of synaptic vesicle exocytosis (GO:2000300)3.27492034
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.27056604
43establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24534078
44mitochondrion transport along microtubule (GO:0047497)3.24534078
45synaptic transmission, glutamatergic (GO:0035249)3.24459955
46synaptic vesicle exocytosis (GO:0016079)3.24269498
47behavioral response to nicotine (GO:0035095)3.21825987
48neuronal action potential propagation (GO:0019227)3.20753854
49NLS-bearing protein import into nucleus (GO:0006607)3.19023597
50pre-miRNA processing (GO:0031054)3.16360186
51glutamate secretion (GO:0014047)3.15923196
52gamma-aminobutyric acid transport (GO:0015812)3.13652428
53neuron-neuron synaptic transmission (GO:0007270)3.09498702
54negative chemotaxis (GO:0050919)3.08019134
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.05771832
56dendritic spine morphogenesis (GO:0060997)3.03304947
57germ cell migration (GO:0008354)3.03240747
58exploration behavior (GO:0035640)3.02469503
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00998885
60auditory behavior (GO:0031223)3.00951392
61intraciliary transport (GO:0042073)2.99088623
62response to host immune response (GO:0052572)2.98017878
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98017878
64detection of biotic stimulus (GO:0009595)2.96137185
65neuronal ion channel clustering (GO:0045161)2.95803603
66mRNA splice site selection (GO:0006376)2.95623317
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95567502
68T-helper 1 type immune response (GO:0042088)2.95501061
69histone H4-K16 acetylation (GO:0043984)2.93535306
70lipopolysaccharide metabolic process (GO:0008653)2.93316106
71histone H3-K9 demethylation (GO:0033169)2.92966086
72central nervous system projection neuron axonogenesis (GO:0021952)2.92594478
73central nervous system neuron axonogenesis (GO:0021955)2.92580722
74synapse organization (GO:0050808)2.91835853
75outer ear morphogenesis (GO:0042473)2.91769478
76calcium ion-dependent exocytosis (GO:0017156)2.91702890
77axon extension (GO:0048675)2.89866805
78neurotransmitter secretion (GO:0007269)2.88756578
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86800285
80response to host (GO:0075136)2.86800285
81response to host defenses (GO:0052200)2.86800285
82regulation of synaptic vesicle transport (GO:1902803)2.85173532
83glutamate receptor signaling pathway (GO:0007215)2.85150572
84positive regulation of gastrulation (GO:2000543)2.83949677
85axon extension involved in axon guidance (GO:0048846)2.83703066
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.83703066
87transmission of nerve impulse (GO:0019226)2.83203445
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82997427
89epithelial cilium movement (GO:0003351)2.82430227
90paraxial mesoderm development (GO:0048339)2.82367949
91cerebral cortex radially oriented cell migration (GO:0021799)2.82038786
92homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.81609528
93peptidyl-arginine omega-N-methylation (GO:0035247)2.79586391
94nucleobase catabolic process (GO:0046113)2.76961808
95macrophage activation involved in immune response (GO:0002281)2.73577007
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72605418
97regulation of cilium movement (GO:0003352)2.71509146
98neuromuscular synaptic transmission (GO:0007274)2.71431643
99hippocampus development (GO:0021766)2.70152095
100glucocorticoid receptor signaling pathway (GO:0042921)2.70068912
101megakaryocyte development (GO:0035855)2.68968400
102neural tube formation (GO:0001841)2.68654300
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67896724
104chemosensory behavior (GO:0007635)2.66188472
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65873643
106regulation of synapse structural plasticity (GO:0051823)2.65462751
107membrane depolarization during action potential (GO:0086010)2.65378916
108retinal cone cell development (GO:0046549)2.65278736
109behavioral response to ethanol (GO:0048149)2.63809863
110regulation of microtubule-based movement (GO:0060632)2.63604363
111mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63525317
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63525317
113regulation of membrane repolarization (GO:0060306)2.63478189
114startle response (GO:0001964)2.62537347
115peptidyl-arginine methylation (GO:0018216)2.62214231
116peptidyl-arginine N-methylation (GO:0035246)2.62214231
117cell migration in hindbrain (GO:0021535)2.60194342
118regulation of telomere maintenance (GO:0032204)2.59462368
119neuron projection extension (GO:1990138)2.56617693
120head development (GO:0060322)2.56527623
121mitotic sister chromatid cohesion (GO:0007064)2.56118323
122cellular response to prostaglandin stimulus (GO:0071379)2.55328041
123protein localization to cilium (GO:0061512)2.54385435
124limb bud formation (GO:0060174)2.53337515
125negative regulation of JAK-STAT cascade (GO:0046426)2.52397637
126regulation of axon guidance (GO:1902667)2.52386652
127negative regulation of histone methylation (GO:0031061)2.51931201
128proline transport (GO:0015824)2.51608249
129urinary tract smooth muscle contraction (GO:0014848)2.50051137
130phosphatidylglycerol biosynthetic process (GO:0006655)2.49101613
131positive regulation of macrophage cytokine production (GO:0060907)2.49021780
132dopamine receptor signaling pathway (GO:0007212)2.48475691
133regulation of mitochondrial fission (GO:0090140)2.47967282
134regulation of type B pancreatic cell apoptotic process (GO:2000674)2.47626329
135negative regulation of dendrite development (GO:2000171)2.46911312
136organelle transport along microtubule (GO:0072384)2.46764468
137cytoskeleton-dependent intracellular transport (GO:0030705)2.46646730
138adult walking behavior (GO:0007628)2.46377409
139microtubule-based transport (GO:0010970)2.46133306
140lactate metabolic process (GO:0006089)2.45675192
141axon cargo transport (GO:0008088)2.45405330
142negative regulation of neurotransmitter transport (GO:0051589)2.45139924
143histone deubiquitination (GO:0016578)2.44582078
144locomotory exploration behavior (GO:0035641)2.43482114
145synaptic vesicle maturation (GO:0016188)2.43300260
146positive regulation of membrane potential (GO:0045838)2.43050641
147regulation of axon extension involved in axon guidance (GO:0048841)2.42758278
148negative regulation of axon extension (GO:0030517)2.42599753
149regulation of vesicle fusion (GO:0031338)2.42004830
150cilium movement (GO:0003341)2.41192308
151ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40980291
152brain morphogenesis (GO:0048854)2.40966754
153neurofilament cytoskeleton organization (GO:0060052)2.39794366
154mechanosensory behavior (GO:0007638)2.39126621
155dendrite morphogenesis (GO:0048813)2.38145350
156regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.37677082
157detection of other organism (GO:0098543)2.37447795
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36672902
159cerebellum development (GO:0021549)2.35337031
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34785021
161negative regulation of alpha-beta T cell activation (GO:0046636)2.34377118
162cell communication by electrical coupling (GO:0010644)2.32877288
163positive regulation of vesicle fusion (GO:0031340)2.32859144
164cerebellar Purkinje cell layer development (GO:0021680)2.29412488
165regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29324493
166positive regulation of RNA splicing (GO:0033120)2.28321583
167stress granule assembly (GO:0034063)2.26897426
168corticosteroid receptor signaling pathway (GO:0031958)2.26795848
169axonal fasciculation (GO:0007413)2.26250560
170regulation of respiratory gaseous exchange (GO:0043576)2.24820579
171histone arginine methylation (GO:0034969)2.20771886
172synaptic vesicle docking involved in exocytosis (GO:0016081)2.20247183
173regulation of secondary heart field cardioblast proliferation (GO:0003266)2.18636331
174regulation of cardioblast proliferation (GO:0003264)2.18636331
175positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18272266
176regulation of telomere maintenance via telomerase (GO:0032210)2.17975954
177necroptotic process (GO:0070266)2.17759366
178protein polyglutamylation (GO:0018095)2.16202851
179regulation of neuron migration (GO:2001222)2.16032530
180peptidyl-lysine methylation (GO:0018022)2.14999226
181lamellipodium assembly (GO:0030032)2.13512743
182neuron maturation (GO:0042551)2.13426265
183beta-amyloid metabolic process (GO:0050435)2.12578452
184lamellipodium organization (GO:0097581)2.12438501
185facial nerve structural organization (GO:0021612)2.11098873
186antigen processing and presentation via MHC class Ib (GO:0002475)2.10614325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.47381728
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.41088908
3EZH2_22144423_ChIP-Seq_EOC_Human3.10480937
4* ZNF274_21170338_ChIP-Seq_K562_Hela2.64846673
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55635681
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.52798978
7TAF15_26573619_Chip-Seq_HEK293_Human2.36127914
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31960234
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20289239
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14438686
11CIITA_25753668_ChIP-Seq_RAJI_Human2.11023557
12DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.05143903
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03301544
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98224080
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97511756
16SMAD4_21799915_ChIP-Seq_A2780_Human1.96648292
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.95607542
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95325997
19MYC_22102868_ChIP-Seq_BL_Human1.93989233
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92716784
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.88134292
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87464563
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85014920
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84146103
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.82349175
26DROSHA_22980978_ChIP-Seq_HELA_Human1.80051034
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79492163
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78503089
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77301125
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76490142
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74824829
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74482216
33TP53_16413492_ChIP-PET_HCT116_Human1.72027712
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.71497395
35GBX2_23144817_ChIP-Seq_PC3_Human1.68222780
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68222719
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67611792
38STAT3_23295773_ChIP-Seq_U87_Human1.63933157
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59844873
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59338417
41RNF2_27304074_Chip-Seq_NSC_Mouse1.58895484
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57493917
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.57402186
44TCF7_22412390_ChIP-Seq_EML_Mouse1.56158442
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56099314
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55106947
47SCL_19346495_ChIP-Seq_HPC-7_Human1.54466462
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53300514
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51592349
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50770507
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50418490
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50276487
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48877436
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48611521
55REST_21632747_ChIP-Seq_MESCs_Mouse1.48041053
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.47987241
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46883002
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46446345
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44258258
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42875179
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41996296
62AR_25329375_ChIP-Seq_VCAP_Human1.41754187
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.41537267
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40404897
65VDR_22108803_ChIP-Seq_LS180_Human1.40293956
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40285613
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40127220
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39955878
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38933185
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37188654
71TCF4_23295773_ChIP-Seq_U87_Human1.37131112
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34302374
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.33995484
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33204733
75SPI1_23127762_ChIP-Seq_K562_Human1.32779521
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32040845
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29861908
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.29507120
79RUNX2_22187159_ChIP-Seq_PCA_Human1.28473366
80RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27965198
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27815410
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27095899
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.26821620
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26320769
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25584724
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24921290
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24603750
88IRF1_19129219_ChIP-ChIP_H3396_Human1.24400475
89BCAT_22108803_ChIP-Seq_LS180_Human1.23239492
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20428525
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19989072
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19913813
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19331343
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19052561
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18843845
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.18351069
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16533827
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.16082240
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16016484
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14463742
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14379720
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14232412
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14217102
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13738148
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13320946
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12856487
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.12737114
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11911183
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11911183
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.11207825
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11041414
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10883355
113ER_23166858_ChIP-Seq_MCF-7_Human1.10762157
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10226355
115JUN_21703547_ChIP-Seq_K562_Human1.09811776
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09208298
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08966576
118KDM2B_26808549_Chip-Seq_REH_Human1.08685035
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08283117
120AR_19668381_ChIP-Seq_PC3_Human1.07643079
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07455227
122AR_21572438_ChIP-Seq_LNCaP_Human1.06562583
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06206056
124CBP_20019798_ChIP-Seq_JUKART_Human1.06206056
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06194811
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06091684
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05830763
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.05341232
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04230897
130BRD4_25478319_ChIP-Seq_HGPS_Human1.03927195
131REST_18959480_ChIP-ChIP_MESCs_Mouse1.03461239
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03237488
133KDM2B_26808549_Chip-Seq_DND41_Human1.02845900
134SMAD3_21741376_ChIP-Seq_ESCs_Human1.02579545
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02074880
136TFEB_21752829_ChIP-Seq_HELA_Human1.01592742
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.01537399
138RARB_27405468_Chip-Seq_BRAIN_Mouse1.01371576
139SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00949498
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00907649
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00099899
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.99717253
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.98747585
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98370517
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.97998793
146RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97074906
147EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97074906
148EWS_26573619_Chip-Seq_HEK293_Human0.96523217
149WDR5_24793694_ChIP-Seq_LNCAP_Human0.95827191
150P300_19829295_ChIP-Seq_ESCs_Human0.95065744
151CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95010712
152MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94353701
153ELK1_19687146_ChIP-ChIP_HELA_Human0.91905559
154GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91745196
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89204338
156RUNX_20019798_ChIP-Seq_JUKART_Human0.87703265
157IGF1R_20145208_ChIP-Seq_DFB_Human0.86993676
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.86517853
159EZH2_27304074_Chip-Seq_ESCs_Mouse0.86355380
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85564313
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.85111621
162FUS_26573619_Chip-Seq_HEK293_Human0.84940889
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84635931
164GATA3_27048872_Chip-Seq_THYMUS_Human0.84011196
165SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83557463
166EZH2_27294783_Chip-Seq_ESCs_Mouse0.82932486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.72672534
2MP0004270_analgesia3.07135976
3MP0002102_abnormal_ear_morphology2.68172636
4MP0003122_maternal_imprinting2.67616929
5MP0004859_abnormal_synaptic_plasticity2.63336679
6MP0010386_abnormal_urinary_bladder2.60774883
7MP0003787_abnormal_imprinting2.51554512
8MP0005367_renal/urinary_system_phenotyp2.45541294
9MP0000516_abnormal_urinary_system2.45541294
10MP0002735_abnormal_chemical_nociception2.45453014
11MP0003183_abnormal_peptide_metabolism2.39008162
12MP0003123_paternal_imprinting2.35458919
13MP0001986_abnormal_taste_sensitivity2.35361509
14MP0008961_abnormal_basal_metabolism2.33918214
15MP0003121_genomic_imprinting2.33439858
16MP0000013_abnormal_adipose_tissue2.32865917
17MP0005187_abnormal_penis_morphology2.22964283
18MP0002734_abnormal_mechanical_nocicepti2.22743413
19MP0001968_abnormal_touch/_nociception2.21484678
20MP0002938_white_spotting2.18739448
21MP0003943_abnormal_hepatobiliary_system2.14390983
22MP0009278_abnormal_bone_marrow2.13805805
23MP0006292_abnormal_olfactory_placode2.11725707
24MP0009745_abnormal_behavioral_response2.06850683
25MP0005670_abnormal_white_adipose2.05485611
26MP0008007_abnormal_cellular_replicative2.02215078
27MP0000678_abnormal_parathyroid_gland1.99424945
28MP0002822_catalepsy1.94569859
29MP0002064_seizures1.93053509
30MP0002572_abnormal_emotion/affect_behav1.92968462
31MP0002272_abnormal_nervous_system1.92178703
32MP0009046_muscle_twitch1.89893919
33MP0003315_abnormal_perineum_morphology1.87075877
34MP0002877_abnormal_melanocyte_morpholog1.85797694
35MP0008877_abnormal_DNA_methylation1.84488879
36MP0003828_pulmonary_edema1.83100939
37MP0003091_abnormal_cell_migration1.78879125
38MP0004130_abnormal_muscle_cell1.72189943
39MP0001486_abnormal_startle_reflex1.71822168
40MP0001970_abnormal_pain_threshold1.68051889
41MP0002736_abnormal_nociception_after1.67147917
42MP0004808_abnormal_hematopoietic_stem1.59197533
43MP0002234_abnormal_pharynx_morphology1.57908113
44MP0002177_abnormal_outer_ear1.56366995
45MP0008057_abnormal_DNA_replication1.56223456
46MP0001299_abnormal_eye_distance/1.55718829
47MP0000569_abnormal_digit_pigmentation1.54440602
48MP0002733_abnormal_thermal_nociception1.52913426
49MP0001529_abnormal_vocalization1.52003112
50MP0005379_endocrine/exocrine_gland_phen1.50058727
51MP0002638_abnormal_pupillary_reflex1.48934320
52MP0002067_abnormal_sensory_capabilities1.48381783
53MP0002557_abnormal_social/conspecific_i1.47810179
54MP0005645_abnormal_hypothalamus_physiol1.46518940
55MP0000465_gastrointestinal_hemorrhage1.46261435
56MP0002184_abnormal_innervation1.44375837
57MP0000631_abnormal_neuroendocrine_gland1.44033199
58MP0001188_hyperpigmentation1.43960720
59MP0001501_abnormal_sleep_pattern1.38008704
60MP0004142_abnormal_muscle_tone1.34899822
61MP0000015_abnormal_ear_pigmentation1.34087340
62MP0005551_abnormal_eye_electrophysiolog1.32758019
63MP0001984_abnormal_olfaction1.29881101
64MP0004742_abnormal_vestibular_system1.29231043
65MP0000003_abnormal_adipose_tissue1.29146328
66MP0000538_abnormal_urinary_bladder1.28463412
67MP0003890_abnormal_embryonic-extraembry1.23506998
68MP0004885_abnormal_endolymph1.22625369
69MP0003633_abnormal_nervous_system1.21575090
70MP0002653_abnormal_ependyma_morphology1.21192972
71MP0003385_abnormal_body_wall1.18667844
72MP0000751_myopathy1.18469496
73MP0002837_dystrophic_cardiac_calcinosis1.17921587
74MP0008569_lethality_at_weaning1.14347443
75MP0005248_abnormal_Harderian_gland1.13945234
76MP0005174_abnormal_tail_pigmentation1.13650059
77MP0003283_abnormal_digestive_organ1.11814917
78MP0005058_abnormal_lysosome_morphology1.11757669
79MP0004133_heterotaxia1.09508828
80MP0003635_abnormal_synaptic_transmissio1.09219247
81MP0003959_abnormal_lean_body1.08606856
82MP0005646_abnormal_pituitary_gland1.08432639
83MP0003279_aneurysm1.08237671
84MP0000049_abnormal_middle_ear1.08045777
85MP0000427_abnormal_hair_cycle1.07563758
86MP0005375_adipose_tissue_phenotype1.06621966
87MP0005423_abnormal_somatic_nervous1.06412483
88MP0002909_abnormal_adrenal_gland1.05336892
89MP0002751_abnormal_autonomic_nervous1.04011350
90MP0000778_abnormal_nervous_system1.03856054
91MP0009384_cardiac_valve_regurgitation1.03744070
92MP0001440_abnormal_grooming_behavior1.01730085
93MP0002066_abnormal_motor_capabilities/c1.00414236
94MP0003631_nervous_system_phenotype0.99140089
95MP0005076_abnormal_cell_differentiation0.99064681
96MP0005253_abnormal_eye_physiology0.98059489
97MP0003935_abnormal_craniofacial_develop0.97968140
98MP0003136_yellow_coat_color0.97572506
99MP0000733_abnormal_muscle_development0.97354849
100MP0005666_abnormal_adipose_tissue0.97296839
101MP0002752_abnormal_somatic_nervous0.96828299
102MP0001270_distended_abdomen0.96670930
103MP0010307_abnormal_tumor_latency0.95987983
104MP0001177_atelectasis0.94240302
105MP0003942_abnormal_urinary_system0.92540458
106MP0004811_abnormal_neuron_physiology0.91859345
107MP0002127_abnormal_cardiovascular_syste0.88698813
108MP0009780_abnormal_chondrocyte_physiolo0.86378386
109MP0008789_abnormal_olfactory_epithelium0.85252979
110MP0000383_abnormal_hair_follicle0.84481695
111MP0003879_abnormal_hair_cell0.83516075
112MP0004145_abnormal_muscle_electrophysio0.82225490
113MP0003861_abnormal_nervous_system0.81957081
114MP0000767_abnormal_smooth_muscle0.81905629
115MP0000534_abnormal_ureter_morphology0.80817419
116MP0001485_abnormal_pinna_reflex0.80009152
117MP0001879_abnormal_lymphatic_vessel0.79970999
118MP0006072_abnormal_retinal_apoptosis0.79959406
119MP0003172_abnormal_lysosome_physiology0.79607584
120MP0003632_abnormal_nervous_system0.79280443
121MP0001849_ear_inflammation0.79129000
122MP0002152_abnormal_brain_morphology0.78981602
123MP0004043_abnormal_pH_regulation0.77954373
124MP0003755_abnormal_palate_morphology0.77413670
125MP0004085_abnormal_heartbeat0.75658605
126MP0004215_abnormal_myocardial_fiber0.75549615
127MP0006276_abnormal_autonomic_nervous0.74484410
128MP0000955_abnormal_spinal_cord0.73886144
129MP0003329_amyloid_beta_deposits0.73599742
130MP0005195_abnormal_posterior_eye0.73539539
131MP0000566_synostosis0.73486222
132MP0002229_neurodegeneration0.73385139
133MP0002090_abnormal_vision0.72964320
134MP0000371_diluted_coat_color0.72214142
135MP0002069_abnormal_eating/drinking_beha0.71696966
136MP0002095_abnormal_skin_pigmentation0.71110115
137MP0002075_abnormal_coat/hair_pigmentati0.69911102
138MP0000681_abnormal_thyroid_gland0.69875471
139MP0003567_abnormal_fetal_cardiomyocyte0.69423944
140MP0004272_abnormal_basement_membrane0.68998521
141MP0002928_abnormal_bile_duct0.68730076
142MP0001324_abnormal_eye_pigmentation0.68240958
143MP0002925_abnormal_cardiovascular_devel0.67344247
144MP0005386_behavior/neurological_phenoty0.66420230
145MP0004924_abnormal_behavior0.66420230
146MP0002882_abnormal_neuron_morphology0.65746959
147MP0001502_abnormal_circadian_rhythm0.64919726
148MP0002116_abnormal_craniofacial_bone0.64601004
149MP0002063_abnormal_learning/memory/cond0.64051946
150MP0005499_abnormal_olfactory_system0.63429337
151MP0005394_taste/olfaction_phenotype0.63429337
152MP0002932_abnormal_joint_morphology0.63158605
153MP0000703_abnormal_thymus_morphology0.62278430
154MP0002081_perinatal_lethality0.61790334
155MP0003880_abnormal_central_pattern0.61310370
156MP0003724_increased_susceptibility_to0.60432680
157MP0003938_abnormal_ear_development0.59209724

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.99068149
2Septate vagina (HP:0001153)3.90955268
3Macroorchidism (HP:0000053)3.50554868
4Gait imbalance (HP:0002141)3.48324558
5Hypothermia (HP:0002045)3.30685979
6Visual hallucinations (HP:0002367)3.22920843
7EEG with generalized epileptiform discharges (HP:0011198)3.17971379
8Epileptiform EEG discharges (HP:0011182)3.17131608
9Volvulus (HP:0002580)3.16757080
10Medial flaring of the eyebrow (HP:0010747)3.14766155
11Central scotoma (HP:0000603)3.12546975
12Hypsarrhythmia (HP:0002521)3.11717800
13Congenital primary aphakia (HP:0007707)3.10038557
14Focal seizures (HP:0007359)3.04502562
15Nephrogenic diabetes insipidus (HP:0009806)3.02461134
16Myokymia (HP:0002411)3.02208589
17Atonic seizures (HP:0010819)2.95913817
18Papillary thyroid carcinoma (HP:0002895)2.93203996
19Genital tract atresia (HP:0001827)2.84400079
20Abnormality of the labia minora (HP:0012880)2.82603659
21Abnormality of the metopic suture (HP:0005556)2.82551879
22Progressive inability to walk (HP:0002505)2.81494961
23Vaginal atresia (HP:0000148)2.78345467
24Hemiparesis (HP:0001269)2.78051056
25Failure to thrive in infancy (HP:0001531)2.71370296
26Abnormality of liposaccharide metabolism (HP:0010968)2.65653570
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.65653570
28Abnormality of glycolipid metabolism (HP:0010969)2.65653570
29Increased cerebral lipofuscin (HP:0011813)2.62192855
30Epileptic encephalopathy (HP:0200134)2.59955003
31Broad-based gait (HP:0002136)2.56223679
32Specific learning disability (HP:0001328)2.55010716
33Intestinal fistula (HP:0100819)2.53625792
34Morphological abnormality of the middle ear (HP:0008609)2.52289086
35Polyphagia (HP:0002591)2.51307205
36Focal motor seizures (HP:0011153)2.49583504
37Exotropia (HP:0000577)2.44672515
38Abnormality of the 4th metacarpal (HP:0010012)2.41950255
39Lissencephaly (HP:0001339)2.41406296
40Hip dysplasia (HP:0001385)2.40750441
41Lower limb amyotrophy (HP:0007210)2.39171883
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.38696386
43Nephronophthisis (HP:0000090)2.38650196
44Pachygyria (HP:0001302)2.37262830
45Astrocytoma (HP:0009592)2.35151151
46Abnormality of the astrocytes (HP:0100707)2.35151151
47Febrile seizures (HP:0002373)2.34819595
48Retinal atrophy (HP:0001105)2.34097293
49Rectal fistula (HP:0100590)2.33310902
50Rectovaginal fistula (HP:0000143)2.33310902
51Abnormality of the intervertebral disk (HP:0005108)2.33229526
52Acute lymphatic leukemia (HP:0006721)2.32183493
53Proximal placement of thumb (HP:0009623)2.32092545
54Prominent metopic ridge (HP:0005487)2.31533327
55Molar tooth sign on MRI (HP:0002419)2.31399078
56Abnormality of midbrain morphology (HP:0002418)2.31399078
57Dialeptic seizures (HP:0011146)2.31031157
58Fatigue (HP:0012378)2.30467662
59Pelvic girdle muscle weakness (HP:0003749)2.29961956
60Hyperacusis (HP:0010780)2.28854965
61Chronic hepatic failure (HP:0100626)2.26331023
62Bowel diverticulosis (HP:0005222)2.22378383
63Poor coordination (HP:0002370)2.21686530
64Cerebral aneurysm (HP:0004944)2.21656636
65Smooth philtrum (HP:0000319)2.19667789
66Tubulointerstitial nephritis (HP:0001970)2.19514867
67Tented upper lip vermilion (HP:0010804)2.19426788
68Elfin facies (HP:0004428)2.18226530
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17560615
70Retinal dysplasia (HP:0007973)2.17467717
71Stridor (HP:0010307)2.16900449
72Hand muscle atrophy (HP:0009130)2.16500826
73Prolonged QT interval (HP:0001657)2.16093931
74Alacrima (HP:0000522)2.15419691
75Aplasia cutis congenita (HP:0001057)2.15230685
76Limb hypertonia (HP:0002509)2.12941942
77Deviation of the thumb (HP:0009603)2.11969910
78Progressive cerebellar ataxia (HP:0002073)2.11885225
79Decreased lacrimation (HP:0000633)2.11567902
80Hematochezia (HP:0002573)2.11561336
81Inappropriate behavior (HP:0000719)2.11502615
82Insulin-resistant diabetes mellitus (HP:0000831)2.10964142
83Shoulder girdle muscle weakness (HP:0003547)2.10538024
84Hypoplastic labia majora (HP:0000059)2.08786731
85Thickened helices (HP:0000391)2.08536702
86Increased nuchal translucency (HP:0010880)2.08379865
87Spastic gait (HP:0002064)2.08347572
88Ulnar claw (HP:0001178)2.06501901
89Myopathic facies (HP:0002058)2.05734977
90Short 4th metacarpal (HP:0010044)2.05171404
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05171404
92Amblyopia (HP:0000646)2.03112133
93Labial hypoplasia (HP:0000066)2.03110520
94Hyperinsulinemic hypoglycemia (HP:0000825)2.01364184
95Postaxial hand polydactyly (HP:0001162)2.00623933
96Absent frontal sinuses (HP:0002688)1.98903690
97Excessive salivation (HP:0003781)1.98580911
98Drooling (HP:0002307)1.98580911
99Birth length less than 3rd percentile (HP:0003561)1.98274089
100Megalencephaly (HP:0001355)1.97926517
101Absent eyebrow (HP:0002223)1.97237986
102Pancreatic fibrosis (HP:0100732)1.96788317
103Abnormality of the renal medulla (HP:0100957)1.96479240
104Broad face (HP:0000283)1.96381783
105Scotoma (HP:0000575)1.96038938
106Cupped ear (HP:0000378)1.95651530
107Optic nerve hypoplasia (HP:0000609)1.95434489
108Vaginal fistula (HP:0004320)1.95348096
109Ependymoma (HP:0002888)1.94002806
110Urinary urgency (HP:0000012)1.93580008
111True hermaphroditism (HP:0010459)1.93328524
112Inability to walk (HP:0002540)1.93251114
113Cerebellar dysplasia (HP:0007033)1.92930610
114Widely spaced teeth (HP:0000687)1.92719092
115Intestinal atresia (HP:0011100)1.91069158
116Abnormality of the endocardium (HP:0004306)1.90750088
117Genetic anticipation (HP:0003743)1.89194498
118Renal duplication (HP:0000075)1.88844173
119Abnormality of the hip-girdle musculature (HP:0001445)1.88637851
120Abnormality of the musculature of the pelvis (HP:0001469)1.88637851
121Absent speech (HP:0001344)1.88498384
122Facial diplegia (HP:0001349)1.88491278
123Medulloblastoma (HP:0002885)1.87813098
124Type II lissencephaly (HP:0007260)1.87592886
125Abnormality of the labia majora (HP:0012881)1.87129281
126Shallow orbits (HP:0000586)1.86860384
127Anteriorly placed anus (HP:0001545)1.86802902
128Generalized tonic-clonic seizures (HP:0002069)1.86281187
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86221452
130Absence seizures (HP:0002121)1.85704970
131Abnormality of salivation (HP:0100755)1.84928170
132Abnormal eating behavior (HP:0100738)1.83647634
133Limb dystonia (HP:0002451)1.83532330
134Ureteral obstruction (HP:0006000)1.82866394
135Mutism (HP:0002300)1.82070350
136Aplasia/Hypoplasia of the lens (HP:0008063)1.80533879
137Glioma (HP:0009733)1.80500726
138Obsessive-compulsive behavior (HP:0000722)1.80262723
139Ankle clonus (HP:0011448)1.80070563
140Papilledema (HP:0001085)1.79947269
141Narrow forehead (HP:0000341)1.79849673
142Colon cancer (HP:0003003)1.79556137
143Striae distensae (HP:0001065)1.79434864
144Hypoplastic female external genitalia (HP:0012815)1.78591575
145Fetal akinesia sequence (HP:0001989)1.78588193
146Arterial tortuosity (HP:0005116)1.78255098
147Frequent falls (HP:0002359)1.78253448
148Hypoplasia of the corpus callosum (HP:0002079)1.78188832
149Sleep apnea (HP:0010535)1.78096610
150Renal hypoplasia (HP:0000089)1.77893968
151Decreased testicular size (HP:0008734)1.77533992
152Severe visual impairment (HP:0001141)1.77260226
153Short philtrum (HP:0000322)1.76869142
154Agitation (HP:0000713)1.76851320
155Abnormal hair whorl (HP:0010721)1.75752888
156Cortical dysplasia (HP:0002539)1.75740508
157Ureteral stenosis (HP:0000071)1.74844151
158Hepatoblastoma (HP:0002884)1.74025841
159Syncope (HP:0001279)1.73492417
160Intellectual disability, severe (HP:0010864)1.72155362
161Short foot (HP:0001773)1.71878209
162Lower limb muscle weakness (HP:0007340)1.70785752
163Flat capital femoral epiphysis (HP:0003370)1.70456276
164Abnormality of the corticospinal tract (HP:0002492)1.70370331
165Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70359923
166Pancreatic cysts (HP:0001737)1.69351475
167Hypoglycemic seizures (HP:0002173)1.69268406
168Bladder diverticulum (HP:0000015)1.68854025
169Amyotrophic lateral sclerosis (HP:0007354)1.68492915
170Abnormal rod and cone electroretinograms (HP:0008323)1.67925954
171Flat cornea (HP:0007720)1.64950579
172Aortic regurgitation (HP:0001659)1.64806856
173Vascular tortuosity (HP:0004948)1.63761915
174Upper limb amyotrophy (HP:0009129)1.63522674
175Distal upper limb amyotrophy (HP:0007149)1.63522674
176Abnormality of the nasolacrimal system (HP:0000614)1.62658150
177Long eyelashes (HP:0000527)1.62406800
178Protruding tongue (HP:0010808)1.62221879
179Round face (HP:0000311)1.61169598
180Long foot (HP:0001833)1.60499673
181Truncal obesity (HP:0001956)1.59706750
182Megalocornea (HP:0000485)1.59314679
183Trigonocephaly (HP:0000243)1.59289963
184Vertebral arch anomaly (HP:0008438)1.59168798
185Dilatation of the ascending aorta (HP:0005111)1.58789998
186Spinal muscular atrophy (HP:0007269)1.58333983
187Enlarged penis (HP:0000040)1.58316816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.74441280
2TNIK4.45844579
3CDK123.59106413
4RIPK13.49465571
5TAOK23.48221349
6WNK33.15223460
7FRK3.12786656
8STK162.86752764
9TIE12.66375728
10MARK12.60315744
11PRPF4B2.39362663
12INSRR2.34891898
13SIK32.25315736
14BCR2.11304366
15EPHA42.04670212
16NLK2.01095681
17YES11.93694780
18TGFBR11.93473133
19CSNK1G21.86872098
20TAOK31.86584644
21MAP3K91.84705610
22STK38L1.75567276
23AKT31.68353629
24PDGFRA1.68258086
25LATS11.67164967
26FGFR21.66583119
27STK381.62962982
28NTRK31.59422029
29ERBB31.54452699
30MAP2K71.51920380
31CSNK1G31.40823613
32TXK1.40728197
33TRIM281.33921142
34PAK61.33816355
35KSR11.32003765
36KIT1.31951790
37CSNK1A1L1.31445226
38CSNK1G11.30244301
39MAP3K41.30025838
40DAPK21.28402746
41FES1.27165820
42SGK2231.24875656
43SGK4941.24875656
44PASK1.24826310
45DYRK31.22339405
46CDK191.21998958
47NUAK11.21503450
48BMPR1B1.21131371
49TTN1.19245001
50CAMKK21.18275993
51PINK11.18040949
52CAMK1G1.16054510
53SGK21.15497116
54PRKCG1.14181701
55PTK61.10349352
56PNCK1.06550693
57PLK21.06387388
58KSR21.05647864
59TYRO31.04376468
60MATK1.03985994
61MAP2K41.03906568
62JAK31.02982237
63PHKG21.02505760
64PHKG11.02505760
65MARK21.02069304
66NEK21.01486672
67PRKCE1.00016472
68MAPK130.97411664
69EPHA30.93791210
70PIM20.92098912
71RIPK40.91476300
72SIK20.90951319
73BRSK20.88337212
74BRD40.88248844
75CAMK2B0.88244231
76TGFBR20.86742677
77ERN10.84796383
78DYRK1A0.84263292
79TEC0.82743961
80CAMK2A0.81780392
81UHMK10.80800280
82ADRBK20.80736740
83MINK10.79865933
84RAF10.76038373
85LIMK10.74873483
86NTRK20.73329582
87PAK30.73061050
88STK110.70746693
89DYRK1B0.69159563
90FGFR40.68389695
91MKNK20.67493232
92PRKD30.67039800
93HIPK20.64745498
94PRKD10.63839920
95PRKD20.63654380
96CSNK1D0.62770664
97MAPKAPK30.62588024
98AKT10.61166564
99ACVR1B0.59952692
100PDGFRB0.59635832
101HCK0.59309331
102SGK30.58510959
103EIF2AK20.58424893
104MKNK10.57822564
105CAMKK10.56378724
106TYK20.55004438
107PAK20.54734261
108CAMK1D0.54567692
109DDR20.54249616
110PRKAA10.53538829
111MAP4K20.53368313
112MAP3K10.53156221
113CHUK0.53023749
114CAMK40.52423939
115WNK40.51020097
116EPHB20.50915846
117CAMK2D0.50813546
118NTRK10.50795542
119AKT20.49757490
120CAMK2G0.49534567
121CDK30.49383089
122ALK0.49353022
123DYRK20.49124221
124STK30.49012574
125MAP3K130.48737403
126MTOR0.48607259
127RET0.47485299
128PRKCZ0.45830635
129RPS6KA20.44908917
130SGK10.44337099
131CSNK1E0.43070879
132CDC42BPA0.43065050
133EGFR0.42530975
134PRKACB0.42382503
135PKN10.41361714
136CDK140.41288417
137PRKACA0.40174363
138MAP3K120.39584081
139CDK50.39479786
140PRKCH0.39401060
141RPS6KA30.39346928
142CAMK10.39253048
143CDK70.38892352
144ZAP700.38288307
145CDK90.36980887
146DMPK0.36395543
147OXSR10.36330305
148PLK40.36140492
149EEF2K0.35681259
150TRIB30.35665393
151MAP2K20.35514185
152CDK180.35486590
153CSNK1A10.34826103
154OBSCN0.34408601
155PKN20.34138262
156MAPK100.32975812
157MAPK80.32775337
158IGF1R0.32403471
159MAP3K110.31619390
160MAP2K10.31448650
161CDK150.30743631
162DAPK10.30620587
163ERBB20.29790046
164CDK11A0.28853285
165GRK10.28803537
166GSK3B0.28803141
167PRKG10.28790737

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73072866
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51049673
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17734645
4Phototransduction_Homo sapiens_hsa047441.84628631
5Colorectal cancer_Homo sapiens_hsa052101.81195216
6Chronic myeloid leukemia_Homo sapiens_hsa052201.79957184
7Amphetamine addiction_Homo sapiens_hsa050311.74407269
8Regulation of autophagy_Homo sapiens_hsa041401.69300726
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57900559
10Butanoate metabolism_Homo sapiens_hsa006501.56910671
11Circadian rhythm_Homo sapiens_hsa047101.55111998
12Type II diabetes mellitus_Homo sapiens_hsa049301.49932962
13Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45238240
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41710910
15Insulin secretion_Homo sapiens_hsa049111.41128362
16Olfactory transduction_Homo sapiens_hsa047401.39864680
17Endometrial cancer_Homo sapiens_hsa052131.39471668
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36872858
19GABAergic synapse_Homo sapiens_hsa047271.36018374
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34400618
21Viral myocarditis_Homo sapiens_hsa054161.32121246
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31724597
23ErbB signaling pathway_Homo sapiens_hsa040121.30106549
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29645716
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26828199
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26216234
27Cholinergic synapse_Homo sapiens_hsa047251.24245193
28GnRH signaling pathway_Homo sapiens_hsa049121.23716446
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21535830
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21518102
31Hepatitis B_Homo sapiens_hsa051611.21116717
32Circadian entrainment_Homo sapiens_hsa047131.19498304
33Long-term potentiation_Homo sapiens_hsa047201.17963797
34Morphine addiction_Homo sapiens_hsa050321.17856357
35Renin secretion_Homo sapiens_hsa049241.15943053
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15576620
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15069857
38Pancreatic cancer_Homo sapiens_hsa052121.14446601
39cAMP signaling pathway_Homo sapiens_hsa040241.12908577
40Dilated cardiomyopathy_Homo sapiens_hsa054141.10762919
41Adherens junction_Homo sapiens_hsa045201.10001579
42Measles_Homo sapiens_hsa051621.07721928
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06821965
44Dopaminergic synapse_Homo sapiens_hsa047281.03914650
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02922783
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02796146
47Acute myeloid leukemia_Homo sapiens_hsa052211.01892713
48ABC transporters_Homo sapiens_hsa020101.01543647
49Estrogen signaling pathway_Homo sapiens_hsa049151.00246502
50Calcium signaling pathway_Homo sapiens_hsa040200.98243960
51Salivary secretion_Homo sapiens_hsa049700.97975009
52T cell receptor signaling pathway_Homo sapiens_hsa046600.97483810
53Gastric acid secretion_Homo sapiens_hsa049710.96680909
54Glioma_Homo sapiens_hsa052140.96649794
55Thyroid cancer_Homo sapiens_hsa052160.96378256
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96109568
57Long-term depression_Homo sapiens_hsa047300.95716331
58Oocyte meiosis_Homo sapiens_hsa041140.95280291
59Collecting duct acid secretion_Homo sapiens_hsa049660.94858170
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94084347
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93364205
62Toxoplasmosis_Homo sapiens_hsa051450.91752054
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91515066
64Platelet activation_Homo sapiens_hsa046110.90799996
65Gap junction_Homo sapiens_hsa045400.90436161
66Basal transcription factors_Homo sapiens_hsa030220.90120547
67Oxytocin signaling pathway_Homo sapiens_hsa049210.88752707
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88334914
69Notch signaling pathway_Homo sapiens_hsa043300.88055402
70Shigellosis_Homo sapiens_hsa051310.87659824
71Serotonergic synapse_Homo sapiens_hsa047260.86834919
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85746609
73Hedgehog signaling pathway_Homo sapiens_hsa043400.85743210
74Glutamatergic synapse_Homo sapiens_hsa047240.84468454
75Synaptic vesicle cycle_Homo sapiens_hsa047210.83878945
76Cocaine addiction_Homo sapiens_hsa050300.83762630
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.83448805
78mRNA surveillance pathway_Homo sapiens_hsa030150.83150547
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82769776
80Insulin signaling pathway_Homo sapiens_hsa049100.81873242
81MicroRNAs in cancer_Homo sapiens_hsa052060.81640267
82Small cell lung cancer_Homo sapiens_hsa052220.81575436
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80682739
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80564266
85Non-small cell lung cancer_Homo sapiens_hsa052230.79837255
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.79774894
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79083412
88Cardiac muscle contraction_Homo sapiens_hsa042600.78838123
89Melanogenesis_Homo sapiens_hsa049160.77508203
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.77320533
91Rap1 signaling pathway_Homo sapiens_hsa040150.76075875
92Type I diabetes mellitus_Homo sapiens_hsa049400.75443514
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74779763
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.74757310
95Axon guidance_Homo sapiens_hsa043600.74656029
96Chemokine signaling pathway_Homo sapiens_hsa040620.74599131
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74557955
98Osteoclast differentiation_Homo sapiens_hsa043800.74363629
99Endocytosis_Homo sapiens_hsa041440.74363025
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73758681
101Hippo signaling pathway_Homo sapiens_hsa043900.73581253
102Prolactin signaling pathway_Homo sapiens_hsa049170.73096578
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71903333
104Proteoglycans in cancer_Homo sapiens_hsa052050.71816557
105Ras signaling pathway_Homo sapiens_hsa040140.71814348
106Apoptosis_Homo sapiens_hsa042100.70948379
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70553284
108Taste transduction_Homo sapiens_hsa047420.70471587
109B cell receptor signaling pathway_Homo sapiens_hsa046620.70312750
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69419353
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69303782
112Cell cycle_Homo sapiens_hsa041100.68836207
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68672070
114mTOR signaling pathway_Homo sapiens_hsa041500.68589501
115Tuberculosis_Homo sapiens_hsa051520.68113611
116Leishmaniasis_Homo sapiens_hsa051400.67744231
117Ovarian steroidogenesis_Homo sapiens_hsa049130.67631276
118HTLV-I infection_Homo sapiens_hsa051660.67405722
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.67016316
120TNF signaling pathway_Homo sapiens_hsa046680.66958436
121beta-Alanine metabolism_Homo sapiens_hsa004100.66684451
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66625212
123AMPK signaling pathway_Homo sapiens_hsa041520.66552217
124Pathways in cancer_Homo sapiens_hsa052000.66520613
125Protein export_Homo sapiens_hsa030600.66421196
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65729202
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.65123402
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.64811302
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64658775
130Lysine degradation_Homo sapiens_hsa003100.64303087
131HIF-1 signaling pathway_Homo sapiens_hsa040660.64269420
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.64131494
133Influenza A_Homo sapiens_hsa051640.64052744
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63375430
135Fatty acid metabolism_Homo sapiens_hsa012120.63065245
136Propanoate metabolism_Homo sapiens_hsa006400.59582589
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58413243
138Ether lipid metabolism_Homo sapiens_hsa005650.58346209
139Tight junction_Homo sapiens_hsa045300.57838695
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53420082
141Basal cell carcinoma_Homo sapiens_hsa052170.53257620
142Steroid biosynthesis_Homo sapiens_hsa001000.50787482
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50655985
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49436896
145Wnt signaling pathway_Homo sapiens_hsa043100.48293831
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45212461
147Glucagon signaling pathway_Homo sapiens_hsa049220.44512198
148Vibrio cholerae infection_Homo sapiens_hsa051100.42450642
149MAPK signaling pathway_Homo sapiens_hsa040100.39667971
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39573066
151Inositol phosphate metabolism_Homo sapiens_hsa005620.39263133
152Pancreatic secretion_Homo sapiens_hsa049720.37250881
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35946912

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