ZFP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.63864408
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.89731477
3axonemal dynein complex assembly (GO:0070286)5.66602025
4aggressive behavior (GO:0002118)5.46217473
5tachykinin receptor signaling pathway (GO:0007217)5.15580677
6interkinetic nuclear migration (GO:0022027)4.84968014
7axoneme assembly (GO:0035082)4.62999970
8cilium movement (GO:0003341)4.61348042
9positive regulation of digestive system process (GO:0060456)4.29245863
10synaptic vesicle maturation (GO:0016188)4.27085333
11positive regulation of action potential (GO:0045760)4.17083701
12positive regulation of uterine smooth muscle contraction (GO:0070474)4.05590493
13positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.05046129
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.02706697
15neurotransmitter-gated ion channel clustering (GO:0072578)3.93953976
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92554609
17retinal cone cell development (GO:0046549)3.86273336
18negative regulation of nitric-oxide synthase activity (GO:0051001)3.84888736
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83221404
20epithelial cilium movement (GO:0003351)3.82615861
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82139211
22NADH metabolic process (GO:0006734)3.77533098
23urinary tract smooth muscle contraction (GO:0014848)3.76747871
24tricarboxylic acid cycle (GO:0006099)3.76315800
25regulation of synaptic vesicle transport (GO:1902803)3.71211554
26regulation of glutamate receptor signaling pathway (GO:1900449)3.71051560
27synaptic vesicle exocytosis (GO:0016079)3.70753268
28vocalization behavior (GO:0071625)3.60622563
29regulation of action potential (GO:0098900)3.60561399
30cardiac muscle contraction (GO:0060048)3.60337967
31regulation of synaptic vesicle exocytosis (GO:2000300)3.59795093
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57835316
33response to ischemia (GO:0002931)3.53365571
34locomotory exploration behavior (GO:0035641)3.52923043
35succinate metabolic process (GO:0006105)3.51826558
36regulation of protein glycosylation (GO:0060049)3.43415068
37oxidative phosphorylation (GO:0006119)3.42969388
38left/right axis specification (GO:0070986)3.41252079
39early endosome to late endosome transport (GO:0045022)3.40748551
40regulation of synapse structural plasticity (GO:0051823)3.40366065
41regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.39978936
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38978449
43regulation of cilium movement (GO:0003352)3.37400278
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33788380
45neuronal action potential propagation (GO:0019227)3.31227957
46actin-myosin filament sliding (GO:0033275)3.30935424
47muscle filament sliding (GO:0030049)3.30935424
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28582973
49regulation of relaxation of muscle (GO:1901077)3.27958906
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26296917
51chaperone-mediated protein transport (GO:0072321)3.25142999
52striated muscle contraction (GO:0006941)3.23203508
53striatum development (GO:0021756)3.22750742
54positive regulation of vascular permeability (GO:0043117)3.22423275
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.22166861
56motile cilium assembly (GO:0044458)3.19653755
57regulation of uterine smooth muscle contraction (GO:0070472)3.18589406
58regulation of female receptivity (GO:0045924)3.16749842
59cellular potassium ion homeostasis (GO:0030007)3.13375764
60pericardium development (GO:0060039)3.11906490
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.11302518
62positive regulation of synapse maturation (GO:0090129)3.10284431
63protein localization to synapse (GO:0035418)3.09829540
64behavioral response to ethanol (GO:0048149)3.08779528
65diterpenoid biosynthetic process (GO:0016102)3.08430970
66energy homeostasis (GO:0097009)3.08244662
67righting reflex (GO:0060013)3.08098595
68membrane assembly (GO:0071709)3.07414997
69sodium ion export (GO:0071436)3.06013097
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.05935097
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05914581
72regulation of metalloenzyme activity (GO:0048552)3.05632979
73behavioral fear response (GO:0001662)3.02247013
74behavioral defense response (GO:0002209)3.02247013
75positive regulation of potassium ion transmembrane transport (GO:1901381)3.02232803
76positive regulation of membrane potential (GO:0045838)3.01107561
77regulation of Rap GTPase activity (GO:0032317)3.00406500
78protein localization to cilium (GO:0061512)2.99844508
79sarcomere organization (GO:0045214)2.99611697
80positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97606681
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97534857
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.95055287
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.95055287
84cardiac myofibril assembly (GO:0055003)2.95006211
85regulation of neuronal synaptic plasticity (GO:0048168)2.94848410
86regulation of synaptic transmission, dopaminergic (GO:0032225)2.94731604
87long-term memory (GO:0007616)2.93979908
88oxaloacetate metabolic process (GO:0006107)2.93710323
89cell communication by electrical coupling (GO:0010644)2.93243988
90inositol phosphate dephosphorylation (GO:0046855)2.89988794
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.89988794
92aerobic respiration (GO:0009060)2.89643901
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89411090
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88897379
95cytoplasmic microtubule organization (GO:0031122)2.87732194
96embryonic heart tube development (GO:0035050)2.87622639
97long term synaptic depression (GO:0060292)2.87570420
98drinking behavior (GO:0042756)2.87523927
99female mating behavior (GO:0060180)2.86000812
100positive regulation of Rap GTPase activity (GO:0032854)2.85564065
101protein complex biogenesis (GO:0070271)2.85386965
102regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84062820
103cilium organization (GO:0044782)2.83261522
104regulation of membrane repolarization (GO:0060306)2.82490945
105detection of calcium ion (GO:0005513)2.82387573
106regulation of the force of heart contraction (GO:0002026)2.81653524
107neuromuscular process controlling posture (GO:0050884)2.80456741
108synaptic transmission, glutamatergic (GO:0035249)2.79809216
109long-term synaptic potentiation (GO:0060291)2.79551704
110mitochondrial respiratory chain complex I assembly (GO:0032981)2.79401295
111NADH dehydrogenase complex assembly (GO:0010257)2.79401295
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79401295
113neurotransmitter secretion (GO:0007269)2.78947567
114exploration behavior (GO:0035640)2.78385601
115negative regulation of monooxygenase activity (GO:0032769)2.78118779
116photoreceptor cell maintenance (GO:0045494)2.77738121
117inositol phosphate catabolic process (GO:0071545)2.77560006
118serotonin metabolic process (GO:0042428)2.74851775
119regulation of microtubule-based movement (GO:0060632)2.73419019
120cytochrome complex assembly (GO:0017004)2.73388818
121negative regulation of protein oligomerization (GO:0032460)2.73075524
122intraciliary transport (GO:0042073)2.71960950
123cilium assembly (GO:0042384)2.71546378
124glutamate receptor signaling pathway (GO:0007215)2.71542954
125negative regulation of immunoglobulin mediated immune response (GO:0002890)2.71403877
126negative regulation of B cell mediated immunity (GO:0002713)2.71403877
127regulation of protein kinase A signaling (GO:0010738)2.71193157
128mitochondrial respiratory chain complex assembly (GO:0033108)2.70948171
129auditory receptor cell stereocilium organization (GO:0060088)2.70830023
130response to auditory stimulus (GO:0010996)2.69669546
131nucleus localization (GO:0051647)2.68847335
132Golgi to endosome transport (GO:0006895)2.67627242
133respiratory chain complex IV assembly (GO:0008535)2.67595810
134neuron-neuron synaptic transmission (GO:0007270)2.67131913
135membrane depolarization during action potential (GO:0086010)2.64865410
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64683743
137glutamate secretion (GO:0014047)2.64266738
138dopamine receptor signaling pathway (GO:0007212)2.64181620
139activation of protein kinase A activity (GO:0034199)2.63524760
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62823492
141ventricular system development (GO:0021591)2.62608164
142purine nucleotide salvage (GO:0032261)2.60258517
143neural tube formation (GO:0001841)2.59473696
144heart contraction (GO:0060047)2.58572403
145heart process (GO:0003015)2.58572403
146response to histamine (GO:0034776)2.58552409
147regulation of glutamate secretion (GO:0014048)2.56869545
148retinal rod cell development (GO:0046548)2.54037501
149establishment of protein localization to Golgi (GO:0072600)2.47447148
150regulation of B cell receptor signaling pathway (GO:0050855)2.46372367
151cellular component assembly involved in morphogenesis (GO:0010927)2.46149116
152positive regulation of granulocyte differentiation (GO:0030854)2.43744726
153microtubule bundle formation (GO:0001578)2.42812485
154kidney morphogenesis (GO:0060993)2.41847686
155regulation of hexokinase activity (GO:1903299)2.40061996
156regulation of glucokinase activity (GO:0033131)2.40061996
157regulation of penile erection (GO:0060405)2.37908077
158polyol catabolic process (GO:0046174)2.37874003
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.37531853
160protein targeting to Golgi (GO:0000042)2.37045016
161brain morphogenesis (GO:0048854)2.34385770
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.34383860
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32372879
164regulation of sarcomere organization (GO:0060297)2.32042268
165terpenoid biosynthetic process (GO:0016114)2.31391258
166monoamine transport (GO:0015844)2.25915069
167dentate gyrus development (GO:0021542)2.25580342
168adaptation of signaling pathway (GO:0023058)2.23680027
169positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.23384025
170positive regulation of vasculogenesis (GO:2001214)2.19612629
171negative regulation of JUN kinase activity (GO:0043508)2.19428726
172regulation of germinal center formation (GO:0002634)2.19075543
173nonmotile primary cilium assembly (GO:0035058)2.16786330
174reflex (GO:0060004)2.16633739
175macroautophagy (GO:0016236)2.16090131
176histone H3-K4 trimethylation (GO:0080182)2.15691719
177carnitine metabolic process (GO:0009437)2.15511421
178protein K11-linked deubiquitination (GO:0035871)2.14792461
179cilium morphogenesis (GO:0060271)2.13580640
180fibroblast migration (GO:0010761)2.12913806
181regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.11295907
182positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.11295907
183negative regulation of bone resorption (GO:0045779)2.10358820
184negative regulation of humoral immune response (GO:0002921)2.09592997
185skeletal muscle contraction (GO:0003009)2.06255159
186phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.04441973
187proline transport (GO:0015824)2.04438256
188adenosine metabolic process (GO:0046085)2.04207560
189nitric oxide mediated signal transduction (GO:0007263)2.03428865
190negative regulation of calcium ion transmembrane transport (GO:1903170)2.03214471
191negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.03214471
192piRNA metabolic process (GO:0034587)2.02848406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.66335919
2EZH2_22144423_ChIP-Seq_EOC_Human3.61378891
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.20863075
4* RARB_27405468_Chip-Seq_BRAIN_Mouse3.14681785
5GBX2_23144817_ChIP-Seq_PC3_Human3.09828442
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.51872163
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.46290399
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.45536878
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44537140
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32626671
11REST_21632747_ChIP-Seq_MESCs_Mouse2.31979681
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23401893
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15285881
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12076142
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07524685
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07342975
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07275529
18VDR_22108803_ChIP-Seq_LS180_Human2.07011267
19CIITA_25753668_ChIP-Seq_RAJI_Human2.03392710
20ER_23166858_ChIP-Seq_MCF-7_Human1.96165552
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89170413
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88389656
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.87637399
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.87242862
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84730819
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84219724
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82427490
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75967978
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73627360
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.73165326
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.72045347
32IGF1R_20145208_ChIP-Seq_DFB_Human1.69639871
33* BCAT_22108803_ChIP-Seq_LS180_Human1.67378971
34* DROSHA_22980978_ChIP-Seq_HELA_Human1.66908618
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65982285
36MYC_22102868_ChIP-Seq_BL_Human1.63165654
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63003610
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61457733
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57872551
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57632469
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57345964
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53860883
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52370542
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51564640
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50755929
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50027454
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.49042220
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48614770
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46140808
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.45009412
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44855947
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44377553
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43469291
54* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40879989
55TCF4_23295773_ChIP-Seq_U87_Human1.39449322
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37161355
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.37067384
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36114581
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36067342
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35901826
61SCL_19346495_ChIP-Seq_HPC-7_Human1.35673609
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34290962
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33969572
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33742315
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32844612
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32359855
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31603276
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.31125386
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30746453
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30086820
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.29055635
72SPI1_23127762_ChIP-Seq_K562_Human1.28581070
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.27971787
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.26739350
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.26731064
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26310364
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25796639
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23702129
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23436584
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23211148
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22370110
82P53_22387025_ChIP-Seq_ESCs_Mouse1.22227463
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22173516
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.20820436
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.20132933
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19838289
87AR_21572438_ChIP-Seq_LNCaP_Human1.18733514
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16973740
89SOX2_19829295_ChIP-Seq_ESCs_Human1.16657671
90NANOG_19829295_ChIP-Seq_ESCs_Human1.16657671
91AHR_22903824_ChIP-Seq_MCF-7_Human1.16213658
92RUNX_20019798_ChIP-Seq_JUKART_Human1.16002491
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.15562939
94* TCF4_22108803_ChIP-Seq_LS180_Human1.15394802
95RXR_22108803_ChIP-Seq_LS180_Human1.15135634
96EWS_26573619_Chip-Seq_HEK293_Human1.14894486
97CDX2_22108803_ChIP-Seq_LS180_Human1.13868764
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13818805
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13748504
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13383683
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.13351890
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12806390
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12624715
104ZNF274_21170338_ChIP-Seq_K562_Hela1.12519030
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11707003
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.11458606
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11424516
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11424516
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11063050
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10925469
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10899861
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.10693394
113RUNX2_22187159_ChIP-Seq_PCA_Human1.10103963
114SMAD4_21799915_ChIP-Seq_A2780_Human1.09652979
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08985355
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07246527
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06339685
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06339685
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06149496
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05897718
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04923766
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.04779289
123TAF15_26573619_Chip-Seq_HEK293_Human1.04509544
124RNF2_27304074_Chip-Seq_ESCs_Mouse1.03499470
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03092950
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02867882
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02317216
128ERG_20517297_ChIP-Seq_VCAP_Human1.00492197
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00452999
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00424919
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00316736
132VDR_24787735_ChIP-Seq_THP-1_Human1.00253312
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99492601
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.99132814
135ZNF263_19887448_ChIP-Seq_K562_Human0.98981392
136SMRT_27268052_Chip-Seq_Bcells_Human0.98949983
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.98720342
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98361461
139KDM2B_26808549_Chip-Seq_REH_Human0.98350362
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97684283
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96965862
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96902222
143P300_18555785_Chip-Seq_ESCs_Mouse0.96836352
144FUS_26573619_Chip-Seq_HEK293_Human0.96507623
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96484963
146TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96237447
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95620398
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.94776009
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94479079
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94377131
151AR_25329375_ChIP-Seq_VCAP_Human0.94269800
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94010603
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.93827023
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.93827023
155CBP_20019798_ChIP-Seq_JUKART_Human0.93048771
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93048771
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92704896
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91848676
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91560304
160* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91501710
161AR_19668381_ChIP-Seq_PC3_Human0.91415190
162DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91261637
163* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91045688
164TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90503846
165P300_19829295_ChIP-Seq_ESCs_Human0.88986872
166EZH2_27304074_Chip-Seq_ESCs_Mouse0.88669329
167TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88552829
168TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88289202
169GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88090530
170CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87838001
171NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87803526
172STAT3_23295773_ChIP-Seq_U87_Human0.87191747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.41230051
2MP0009780_abnormal_chondrocyte_physiolo4.27246189
3MP0003646_muscle_fatigue4.16345148
4MP0002277_abnormal_respiratory_mucosa3.42829539
5MP0002822_catalepsy3.20122970
6MP0004043_abnormal_pH_regulation3.07715858
7MP0003191_abnormal_cellular_cholesterol2.96869150
8MP0000751_myopathy2.74190549
9MP0003950_abnormal_plasma_membrane2.74127789
10MP0003635_abnormal_synaptic_transmissio2.62933640
11MP0000749_muscle_degeneration2.53881758
12MP0005360_urolithiasis2.53066174
13MP0008877_abnormal_DNA_methylation2.46067781
14MP0004270_analgesia2.44351227
15MP0004145_abnormal_muscle_electrophysio2.26893411
16MP0002063_abnormal_learning/memory/cond2.19648198
17MP0002332_abnormal_exercise_endurance2.11330693
18MP0004215_abnormal_myocardial_fiber2.07280227
19MP0002735_abnormal_chemical_nociception2.05464232
20MP0009745_abnormal_behavioral_response2.00281796
21MP0004036_abnormal_muscle_relaxation1.96725718
22MP0004147_increased_porphyrin_level1.96138183
23MP0003183_abnormal_peptide_metabolism1.95361748
24MP0002909_abnormal_adrenal_gland1.93371985
25MP0004510_myositis1.92087089
26MP0002837_dystrophic_cardiac_calcinosis1.90026254
27MP0003705_abnormal_hypodermis_morpholog1.88101519
28MP0008872_abnormal_physiological_respon1.81856599
29MP0005330_cardiomyopathy1.76676705
30MP0002106_abnormal_muscle_physiology1.76625662
31MP0001529_abnormal_vocalization1.76228243
32MP0003880_abnormal_central_pattern1.73643841
33MP0002064_seizures1.72450605
34MP0000747_muscle_weakness1.71309134
35MP0002572_abnormal_emotion/affect_behav1.62216887
36MP0004233_abnormal_muscle_weight1.60434661
37MP0003195_calcinosis1.56712450
38MP0000569_abnormal_digit_pigmentation1.54238727
39MP0002272_abnormal_nervous_system1.53788674
40MP0004084_abnormal_cardiac_muscle1.53600893
41MP0004087_abnormal_muscle_fiber1.52545046
42MP0008569_lethality_at_weaning1.51218361
43MP0005620_abnormal_muscle_contractility1.50328460
44MP0002269_muscular_atrophy1.49855079
45MP0003787_abnormal_imprinting1.44324353
46MP0005646_abnormal_pituitary_gland1.43968158
47MP0001853_heart_inflammation1.43896393
48MP0009046_muscle_twitch1.40584068
49MP0002138_abnormal_hepatobiliary_system1.39607308
50MP0008995_early_reproductive_senescence1.39526177
51MP0001188_hyperpigmentation1.39492644
52MP0001984_abnormal_olfaction1.39370760
53MP0003045_fibrosis1.39180304
54MP0001986_abnormal_taste_sensitivity1.38198726
55MP0005075_abnormal_melanosome_morpholog1.37178865
56MP0005645_abnormal_hypothalamus_physiol1.36871664
57MP0003724_increased_susceptibility_to1.35125806
58MP0000427_abnormal_hair_cycle1.34934214
59MP0000759_abnormal_skeletal_muscle1.32798644
60MP0006138_congestive_heart_failure1.30537059
61MP0002972_abnormal_cardiac_muscle1.29093213
62MP0006036_abnormal_mitochondrial_physio1.27480012
63MP0005369_muscle_phenotype1.26314381
64MP0003221_abnormal_cardiomyocyte_apopto1.23179062
65MP0003879_abnormal_hair_cell1.22007929
66MP0001501_abnormal_sleep_pattern1.21519166
67MP0005551_abnormal_eye_electrophysiolog1.19665716
68MP0003828_pulmonary_edema1.18932310
69MP0005386_behavior/neurological_phenoty1.18241608
70MP0004924_abnormal_behavior1.18241608
71MP0001835_abnormal_antigen_presentation1.17958145
72MP0001968_abnormal_touch/_nociception1.16112548
73MP0004130_abnormal_muscle_cell1.15275183
74MP0004484_altered_response_of1.15144882
75MP0003137_abnormal_impulse_conducting1.15087984
76MP0000383_abnormal_hair_follicle1.14991241
77MP0001545_abnormal_hematopoietic_system1.14818033
78MP0005397_hematopoietic_system_phenotyp1.14818033
79MP0010352_gastrointestinal_tract_polyps1.13363397
80MP0004885_abnormal_endolymph1.12288524
81MP0002067_abnormal_sensory_capabilities1.10469120
82MP0002876_abnormal_thyroid_physiology1.10233910
83MP0002132_abnormal_respiratory_system1.10125222
84MP0002168_other_aberrant_phenotype1.09347870
85MP0001486_abnormal_startle_reflex1.08844862
86MP0003329_amyloid_beta_deposits1.07923252
87MP0002734_abnormal_mechanical_nocicepti1.07189213
88MP0000465_gastrointestinal_hemorrhage1.06445591
89MP0002638_abnormal_pupillary_reflex1.05362217
90MP0003075_altered_response_to1.04617317
91MP0008961_abnormal_basal_metabolism1.04449259
92MP0006035_abnormal_mitochondrial_morpho1.03944521
93MP0005253_abnormal_eye_physiology1.03600175
94MP0001765_abnormal_ion_homeostasis1.02036677
95MP0004085_abnormal_heartbeat1.01618365
96MP0005266_abnormal_metabolism0.99795642
97MP0001544_abnormal_cardiovascular_syste0.98057038
98MP0005385_cardiovascular_system_phenoty0.98057038
99MP0006082_CNS_inflammation0.97623471
100MP0001970_abnormal_pain_threshold0.97388450
101MP0005409_darkened_coat_color0.97144809
102MP0000685_abnormal_immune_system0.96151816
103MP0010368_abnormal_lymphatic_system0.96096293
104MP0005310_abnormal_salivary_gland0.95486556
105MP0009697_abnormal_copulation0.94644666
106MP0001800_abnormal_humoral_immune0.94324186
107MP0002736_abnormal_nociception_after0.93149436
108MP0002557_abnormal_social/conspecific_i0.92771583
109MP0008875_abnormal_xenobiotic_pharmacok0.91721478
110MP0006054_spinal_hemorrhage0.89613073
111MP0010386_abnormal_urinary_bladder0.88835407
112MP0005535_abnormal_body_temperature0.88157901
113MP0008775_abnormal_heart_ventricle0.87880745
114MP0005174_abnormal_tail_pigmentation0.87219032
115MP0001879_abnormal_lymphatic_vessel0.86203934
116MP0004811_abnormal_neuron_physiology0.85941913
117MP0003763_abnormal_thymus_physiology0.85069075
118MP0003656_abnormal_erythrocyte_physiolo0.84195158
119MP0002229_neurodegeneration0.83385605
120MP0002163_abnormal_gland_morphology0.83105573
121MP0002751_abnormal_autonomic_nervous0.82353766
122MP0005379_endocrine/exocrine_gland_phen0.81009335
123MP0001756_abnormal_urination0.79276613
124MP0002928_abnormal_bile_duct0.79127791
125MP0002066_abnormal_motor_capabilities/c0.78480902
126MP0002184_abnormal_innervation0.78171699
127MP0002933_joint_inflammation0.78159694
128MP0002653_abnormal_ependyma_morphology0.76345376
129MP0002971_abnormal_brown_adipose0.75766192
130MP0002127_abnormal_cardiovascular_syste0.75278995
131MP0001790_abnormal_immune_system0.75133069
132MP0005387_immune_system_phenotype0.75133069
133MP0001502_abnormal_circadian_rhythm0.74751283
134MP0003631_nervous_system_phenotype0.74705571
135MP0000230_abnormal_systemic_arterial0.74432576
136MP0008789_abnormal_olfactory_epithelium0.73901235
137MP0005395_other_phenotype0.73635642
138MP0010678_abnormal_skin_adnexa0.73342590
139MP0006276_abnormal_autonomic_nervous0.72543067
140MP0000372_irregular_coat_pigmentation0.72378860
141MP0000681_abnormal_thyroid_gland0.72366060
142MP0000613_abnormal_salivary_gland0.72361406
143MP0002733_abnormal_thermal_nociception0.71056140
144MP0000750_abnormal_muscle_regeneration0.70984231
145MP0001485_abnormal_pinna_reflex0.70258154
146MP0001944_abnormal_pancreas_morphology0.69344249
147MP0001664_abnormal_digestion0.69068215
148MP0002693_abnormal_pancreas_physiology0.67275158
149MP0003633_abnormal_nervous_system0.66083371
150MP0003567_abnormal_fetal_cardiomyocyte0.65228192
151MP0008874_decreased_physiological_sensi0.63970912
152MP0004142_abnormal_muscle_tone0.63441182
153MP0000604_amyloidosis0.61481669

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.54958017
2Absent/shortened dynein arms (HP:0200106)5.54958017
3Focal motor seizures (HP:0011153)5.39188722
4Abnormal respiratory epithelium morphology (HP:0012253)5.09610368
5Abnormal respiratory motile cilium morphology (HP:0005938)5.09610368
6Abnormal ciliary motility (HP:0012262)5.08699896
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.06298287
8Abnormal respiratory motile cilium physiology (HP:0012261)4.80895200
9Exercise-induced myalgia (HP:0003738)4.32141268
10Rhinitis (HP:0012384)4.08173224
11Myokymia (HP:0002411)3.97879723
12Bronchiectasis (HP:0002110)3.77045280
13Exercise-induced muscle cramps (HP:0003710)3.73132240
14Visual hallucinations (HP:0002367)3.43065605
15Atonic seizures (HP:0010819)3.29679026
16Muscle hypertrophy of the lower extremities (HP:0008968)3.27551952
17Calf muscle hypertrophy (HP:0008981)3.27017637
18Ragged-red muscle fibers (HP:0003200)3.26704396
19Chronic hepatic failure (HP:0100626)3.14368567
20Molar tooth sign on MRI (HP:0002419)3.11643902
21Abnormality of midbrain morphology (HP:0002418)3.11643902
22Absence seizures (HP:0002121)3.10099806
23Hepatocellular necrosis (HP:0001404)3.04227550
24Growth hormone excess (HP:0000845)3.03231946
25Focal seizures (HP:0007359)3.02821124
26Chronic bronchitis (HP:0004469)2.97855939
27Chronic sinusitis (HP:0011109)2.92867367
28Pancreatic cysts (HP:0001737)2.91068624
29Myotonia (HP:0002486)2.90103942
30Nephronophthisis (HP:0000090)2.86763776
31Dialeptic seizures (HP:0011146)2.80866001
32Hyperventilation (HP:0002883)2.80799847
33True hermaphroditism (HP:0010459)2.77738921
34Myoglobinuria (HP:0002913)2.77709925
35Reduced subcutaneous adipose tissue (HP:0003758)2.74233328
36Medial flaring of the eyebrow (HP:0010747)2.73719088
37Poor eye contact (HP:0000817)2.71574330
38Absent speech (HP:0001344)2.69724479
39Panhypogammaglobulinemia (HP:0003139)2.68760951
40Hepatic necrosis (HP:0002605)2.67394271
41Glucose intolerance (HP:0000833)2.64274165
42Abnormal mitochondria in muscle tissue (HP:0008316)2.63380860
43Sudden death (HP:0001699)2.62752739
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61318362
45Bundle branch block (HP:0011710)2.58663303
46Neuroendocrine neoplasm (HP:0100634)2.58137952
47Lipoatrophy (HP:0100578)2.54072143
48Cerebellar dysplasia (HP:0007033)2.53798612
49Abnormality of the renal medulla (HP:0100957)2.51235798
50Microvesicular hepatic steatosis (HP:0001414)2.48379825
51Supraventricular tachycardia (HP:0004755)2.47730085
52Recurrent sinusitis (HP:0011108)2.46987370
53EMG: myopathic abnormalities (HP:0003458)2.46684387
54Primary atrial arrhythmia (HP:0001692)2.45704640
55Hypertensive crisis (HP:0100735)2.45679430
56Pheochromocytoma (HP:0002666)2.44546241
57Poor speech (HP:0002465)2.44274321
58Left ventricular hypertrophy (HP:0001712)2.44188962
59Truncus arteriosus (HP:0001660)2.42965711
60Bronchitis (HP:0012387)2.42353646
61Large hands (HP:0001176)2.42256079
62Progressive inability to walk (HP:0002505)2.37690814
63Impaired social interactions (HP:0000735)2.37146792
64Abnormal social behavior (HP:0012433)2.37146792
65Abnormality of the renal cortex (HP:0011035)2.36962990
66Atrial fibrillation (HP:0005110)2.36710119
67Supraventricular arrhythmia (HP:0005115)2.35443630
68Acute necrotizing encephalopathy (HP:0006965)2.32563484
69Mitochondrial inheritance (HP:0001427)2.32269603
70Ventricular tachycardia (HP:0004756)2.26899159
71Palpitations (HP:0001962)2.24765753
72Increased CSF lactate (HP:0002490)2.24638277
73Neoplasm of the peripheral nervous system (HP:0100007)2.24517398
74Abnormality of the calf musculature (HP:0001430)2.23942476
75Muscle fiber inclusion bodies (HP:0100299)2.23664738
76Chronic otitis media (HP:0000389)2.23242863
77Papilledema (HP:0001085)2.22633255
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.22451455
79Congenital primary aphakia (HP:0007707)2.21369109
80Cone-rod dystrophy (HP:0000548)2.21356948
81Xerostomia (HP:0000217)2.20914505
82Truncal ataxia (HP:0002078)2.20864187
83Annular pancreas (HP:0001734)2.19012571
84Constricted visual fields (HP:0001133)2.16866633
85Abnormal rod and cone electroretinograms (HP:0008323)2.16211108
86Hypothermia (HP:0002045)2.16104132
87Hemiplegia (HP:0002301)2.15535541
88Decreased circulating renin level (HP:0003351)2.15517689
89Generalized tonic-clonic seizures (HP:0002069)2.15231153
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14807699
91Febrile seizures (HP:0002373)2.14263288
92Mucosal telangiectasiae (HP:0100579)2.14161545
93Clonus (HP:0002169)2.14004234
94Lower limb muscle weakness (HP:0007340)2.13693794
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.13563445
96Epileptic encephalopathy (HP:0200134)2.13536748
97Nasal polyposis (HP:0100582)2.12318806
98Muscular hypotonia of the trunk (HP:0008936)2.12094434
99Pancreatic fibrosis (HP:0100732)2.11670160
100Widely spaced teeth (HP:0000687)2.10425987
101Agitation (HP:0000713)2.05575690
102Congenital hepatic fibrosis (HP:0002612)2.05221472
103Rhabdomyolysis (HP:0003201)2.04914303
104Impaired vibration sensation in the lower limbs (HP:0002166)2.04722771
105Anxiety (HP:0000739)2.04624809
106Recurrent bronchitis (HP:0002837)2.04195819
107Gaze-evoked nystagmus (HP:0000640)2.02407714
108Hyperactive renin-angiotensin system (HP:0000841)2.02228046
109Infertility (HP:0000789)2.01800015
110Abnormality of glycolysis (HP:0004366)2.01764877
111Increased serum pyruvate (HP:0003542)2.01764877
112Congenital malformation of the right heart (HP:0011723)2.00957491
113Double outlet right ventricle (HP:0001719)2.00957491
114Cystic liver disease (HP:0006706)1.97771308
115Difficulty running (HP:0009046)1.97189058
116Nemaline bodies (HP:0003798)1.96379129
117Tubulointerstitial nephritis (HP:0001970)1.96271797
118Achilles tendon contracture (HP:0001771)1.95785750
119Subaortic stenosis (HP:0001682)1.94883306
120Abnormality of the left ventricular outflow tract (HP:0011103)1.94883306
121Gait imbalance (HP:0002141)1.93534379
122Hemiparesis (HP:0001269)1.92223593
123Abnormality of macular pigmentation (HP:0008002)1.91867077
124Nephrogenic diabetes insipidus (HP:0009806)1.91795582
125Acute encephalopathy (HP:0006846)1.91688069
126Hyperkalemia (HP:0002153)1.91046653
127Abnormal glucose tolerance (HP:0001952)1.90860590
128Decreased central vision (HP:0007663)1.90589798
129Orthostatic hypotension (HP:0001278)1.90265778
130Popliteal pterygium (HP:0009756)1.88603485
131Abnormal EKG (HP:0003115)1.88571526
132Rimmed vacuoles (HP:0003805)1.88300285
133Depression (HP:0000716)1.88201354
134Increased CSF protein (HP:0002922)1.87986371
135Distal arthrogryposis (HP:0005684)1.86554275
136Tubular atrophy (HP:0000092)1.86279213
137Fetal akinesia sequence (HP:0001989)1.85837713
138Dysmetric saccades (HP:0000641)1.85750544
139Tubulointerstitial abnormality (HP:0001969)1.85364546
140Chronic mucocutaneous candidiasis (HP:0002728)1.85238281
141Recurrent cutaneous fungal infections (HP:0011370)1.85238281
142Abnormal drinking behavior (HP:0030082)1.85122151
143Polydipsia (HP:0001959)1.85122151
144Exercise intolerance (HP:0003546)1.84775733
145Papilloma (HP:0012740)1.82498565
146Verrucae (HP:0200043)1.82498565
147Attenuation of retinal blood vessels (HP:0007843)1.82497860
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80689252
149Emotional lability (HP:0000712)1.79071592
150Abnormality of the nasal mucosa (HP:0000433)1.78571214
151Prolonged QT interval (HP:0001657)1.77778351
152Menstrual irregularities (HP:0000858)1.77261423
153Shoulder girdle muscle weakness (HP:0003547)1.77081764
154Broad-based gait (HP:0002136)1.76941764
155Ventricular arrhythmia (HP:0004308)1.76847515
156Abnormal biliary tract physiology (HP:0012439)1.76529471
157Bile duct proliferation (HP:0001408)1.76529471
158Myopathic facies (HP:0002058)1.76317949
159Type II lissencephaly (HP:0007260)1.75675604
160Torticollis (HP:0000473)1.75349619
161Congenital sensorineural hearing impairment (HP:0008527)1.75299211
162Hypokalemic alkalosis (HP:0001949)1.74999292
163Cholelithiasis (HP:0001081)1.74739695
164Abnormality of the Achilles tendon (HP:0005109)1.74502069
165Thyroiditis (HP:0100646)1.73255814
166Progressive cerebellar ataxia (HP:0002073)1.72406712
167Ankle clonus (HP:0011448)1.72212169
168Renal cortical cysts (HP:0000803)1.71518411
169Macular degeneration (HP:0000608)1.70772893
170Muscle fiber splitting (HP:0003555)1.70280931
171Stomatitis (HP:0010280)1.70071765
172Dyschromatopsia (HP:0007641)1.67962466
173Type 2 muscle fiber atrophy (HP:0003554)1.66838245
174Nonprogressive disorder (HP:0003680)1.65842364
175Postaxial foot polydactyly (HP:0001830)1.65330873
176Genetic anticipation (HP:0003743)1.64089552
177Postaxial hand polydactyly (HP:0001162)1.63818375
178Dysdiadochokinesis (HP:0002075)1.63223114
179Agammaglobulinemia (HP:0004432)1.62274110
180Amyotrophic lateral sclerosis (HP:0007354)1.62050068
181Occipital encephalocele (HP:0002085)1.61997714
182Genital tract atresia (HP:0001827)1.61996072
183Facial diplegia (HP:0001349)1.60864246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.24305844
2ARAF3.07591098
3MAP3K92.97093647
4NTRK32.87814367
5PHKG22.74329081
6PHKG12.74329081
7EPHA42.71492487
8CDK82.50970038
9TNIK2.50127382
10RAF12.44414579
11TAOK32.42908878
12KSR22.40423344
13MAP3K122.34579281
14OBSCN2.26541200
15WNK32.25429041
16KSR12.22488982
17SIK32.07800212
18MAPK152.06570552
19PBK2.05802726
20MAP3K131.95650697
21BCKDK1.93254139
22MUSK1.85437908
23PRKD31.73738744
24MAP3K41.69023634
25MAP4K21.63778669
26DAPK11.59883770
27CASK1.58644616
28PIK3CG1.58346358
29KIT1.57847493
30NUAK11.56225307
31TNK21.54595553
32EIF2AK31.52742107
33BRD41.40207513
34GRK11.39512352
35CCNB11.37533818
36MINK11.37072577
37MAPKAPK31.32464554
38ERBB31.30870527
39BRAF1.29850680
40CAMKK11.29131123
41IRAK11.25796082
42CAMKK21.25222497
43SCYL21.22070143
44SGK21.20269890
45MAPK131.18586768
46PINK11.17238614
47FES1.16455857
48PRKCE1.12585788
49PDK21.12206049
50PRPF4B1.10781737
51STK241.08586387
52TRPM71.07771781
53BMPR21.07062161
54NEK61.07033188
55MAP2K71.03433030
56DMPK1.02901089
57PRKCQ1.01172187
58NLK0.98317198
59DYRK30.98243317
60PRKCH0.98067952
61ADRBK20.95742318
62CDK190.93179549
63IKBKE0.93130333
64PAK30.92978693
65OXSR10.91773776
66PIK3CA0.91364755
67TTN0.91266080
68TEC0.91073265
69EEF2K0.90218653
70SGK30.88123137
71HIPK20.86580633
72TGFBR10.85388666
73CDK50.85317705
74PTK2B0.84660908
75PRKCG0.83677000
76NTRK20.82382178
77ITK0.82319125
78FGFR20.80965305
79NME10.79910617
80TYK20.78642118
81SGK2230.78432806
82SGK4940.78432806
83MAPK70.78262628
84MYLK0.77990848
85PAK60.77457389
86BCR0.76869575
87PRKAA20.76579728
88PKN20.75083949
89MAP3K10.74710886
90NEK90.74617911
91MAP4K10.74484583
92JAK10.74281029
93UHMK10.73834285
94RPS6KA20.72945977
95MARK10.72279349
96FER0.72239687
97SYK0.71973269
98FLT30.71071381
99HCK0.70994631
100MARK20.70685732
101CSF1R0.69588957
102CAMK10.69288091
103SIK20.67846069
104MAP3K20.67326124
105STK110.67321923
106BLK0.67079707
107CAMK2D0.66664752
108MAP2K40.65408473
109CAMK2A0.65284222
110CAMK40.65224542
111PRKD20.64594644
112RPS6KA40.64219232
113PLK20.63776373
114PRKAA10.63725093
115MAP3K70.61923506
116ABL10.61349407
117MAPK110.61323793
118NME20.61243945
119TXK0.61065167
120TAOK20.59623749
121NEK10.58517064
122INSRR0.58104159
123MST40.58006080
124CDK30.57444325
125MAPK120.57063182
126LMTK20.56992156
127TRIB30.55242664
128PDK10.54292672
129PASK0.53299777
130CSNK1G20.53103525
131BMPR1B0.52700100
132PRKCI0.50346958
133ROCK10.49769932
134PRKACA0.48280420
135LYN0.48087399
136IKBKB0.48022357
137MOS0.47812033
138AKT30.47611019
139PKN10.47423704
140DAPK20.47224043
141LCK0.46502054
142CDK180.45119411
143PRKG10.43485157
144PRKG20.43415795
145CSK0.42524510
146PNCK0.42279549
147PRKCA0.42063625
148STK380.39996384
149TIE10.39367802
150CAMK2G0.38093477
151PDK30.37741339
152PDK40.37741339
153PTK60.36161303
154CAMK2B0.33872755
155PRKACB0.32690406
156TAOK10.31874089
157CDK150.30660190
158RPS6KB10.29469035
159IRAK40.28868644
160MAPK100.28819295
161TBK10.28745092
162GRK60.27943586

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.64163046
2Olfactory transduction_Homo sapiens_hsa047403.18078542
3Nicotine addiction_Homo sapiens_hsa050332.72501091
4Synaptic vesicle cycle_Homo sapiens_hsa047212.62343068
5Long-term potentiation_Homo sapiens_hsa047202.61727019
6Cardiac muscle contraction_Homo sapiens_hsa042602.37085675
7Circadian entrainment_Homo sapiens_hsa047132.30523699
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18735899
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02474453
10Amphetamine addiction_Homo sapiens_hsa050312.02394482
11Morphine addiction_Homo sapiens_hsa050322.00313427
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.98333520
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96721962
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90014985
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89186510
16Insulin secretion_Homo sapiens_hsa049111.87785676
17GABAergic synapse_Homo sapiens_hsa047271.86528413
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85503588
19Glutamatergic synapse_Homo sapiens_hsa047241.81783521
20ABC transporters_Homo sapiens_hsa020101.75215503
21Linoleic acid metabolism_Homo sapiens_hsa005911.72809822
22Regulation of autophagy_Homo sapiens_hsa041401.68263787
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67815549
24Dopaminergic synapse_Homo sapiens_hsa047281.67608639
25Dilated cardiomyopathy_Homo sapiens_hsa054141.67170627
26Butanoate metabolism_Homo sapiens_hsa006501.65713744
27Parkinsons disease_Homo sapiens_hsa050121.65104987
28Dorso-ventral axis formation_Homo sapiens_hsa043201.62809831
29Type I diabetes mellitus_Homo sapiens_hsa049401.61353818
30Cholinergic synapse_Homo sapiens_hsa047251.59970229
31Oxytocin signaling pathway_Homo sapiens_hsa049211.59541739
32Calcium signaling pathway_Homo sapiens_hsa040201.56378358
33Oxidative phosphorylation_Homo sapiens_hsa001901.55878750
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49080407
35Salivary secretion_Homo sapiens_hsa049701.46633199
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45091502
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45072641
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42462377
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37108269
40Long-term depression_Homo sapiens_hsa047301.33567842
41Renin secretion_Homo sapiens_hsa049241.29637647
42Gastric acid secretion_Homo sapiens_hsa049711.26856961
43Collecting duct acid secretion_Homo sapiens_hsa049661.22961665
44Glucagon signaling pathway_Homo sapiens_hsa049221.21664457
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20913693
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18930641
47Ether lipid metabolism_Homo sapiens_hsa005651.16893577
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14215301
49Chemical carcinogenesis_Homo sapiens_hsa052041.13418059
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12062160
51cAMP signaling pathway_Homo sapiens_hsa040241.11122599
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10278160
53Ovarian steroidogenesis_Homo sapiens_hsa049131.09059867
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08938258
55Alzheimers disease_Homo sapiens_hsa050101.08157007
56Vibrio cholerae infection_Homo sapiens_hsa051101.07070977
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06170962
58Non-small cell lung cancer_Homo sapiens_hsa052231.05018883
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04864405
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03813962
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03259966
62Sphingolipid metabolism_Homo sapiens_hsa006001.03088281
63Allograft rejection_Homo sapiens_hsa053301.02945059
64GnRH signaling pathway_Homo sapiens_hsa049121.02502835
65Cocaine addiction_Homo sapiens_hsa050301.02270984
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.00451970
67Gap junction_Homo sapiens_hsa045401.00192013
68Serotonergic synapse_Homo sapiens_hsa047260.99884176
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99280567
70Asthma_Homo sapiens_hsa053100.98417836
71Pancreatic secretion_Homo sapiens_hsa049720.97430041
72Peroxisome_Homo sapiens_hsa041460.96922936
73Phototransduction_Homo sapiens_hsa047440.95456184
74Arachidonic acid metabolism_Homo sapiens_hsa005900.95161730
75Histidine metabolism_Homo sapiens_hsa003400.95072611
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.94027151
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93997531
78Glioma_Homo sapiens_hsa052140.92699845
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.91595654
80beta-Alanine metabolism_Homo sapiens_hsa004100.91252703
81Huntingtons disease_Homo sapiens_hsa050160.88436892
82Hematopoietic cell lineage_Homo sapiens_hsa046400.87114748
83Circadian rhythm_Homo sapiens_hsa047100.85960244
84Insulin signaling pathway_Homo sapiens_hsa049100.83657497
85Taste transduction_Homo sapiens_hsa047420.82731289
86Autoimmune thyroid disease_Homo sapiens_hsa053200.80258621
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.79490406
88Oocyte meiosis_Homo sapiens_hsa041140.78786989
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78761567
90Graft-versus-host disease_Homo sapiens_hsa053320.78286279
91Carbon metabolism_Homo sapiens_hsa012000.77803890
92Propanoate metabolism_Homo sapiens_hsa006400.77352040
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77178444
94Pyruvate metabolism_Homo sapiens_hsa006200.77015340
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75225063
96Biosynthesis of amino acids_Homo sapiens_hsa012300.75208820
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74392291
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74231627
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71850559
100N-Glycan biosynthesis_Homo sapiens_hsa005100.71196772
101Nitrogen metabolism_Homo sapiens_hsa009100.71158857
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71148917
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71117379
104Type II diabetes mellitus_Homo sapiens_hsa049300.70613480
105Measles_Homo sapiens_hsa051620.67723186
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66138821
107Thyroid hormone synthesis_Homo sapiens_hsa049180.65864856
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65760054
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64805633
110Rheumatoid arthritis_Homo sapiens_hsa053230.63954115
111MAPK signaling pathway_Homo sapiens_hsa040100.63810350
112Melanogenesis_Homo sapiens_hsa049160.63551376
113Tuberculosis_Homo sapiens_hsa051520.63409184
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62463675
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62311740
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59856144
117Basal transcription factors_Homo sapiens_hsa030220.59582874
118Colorectal cancer_Homo sapiens_hsa052100.59188909
119Rap1 signaling pathway_Homo sapiens_hsa040150.59049354
120Tryptophan metabolism_Homo sapiens_hsa003800.57694230
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57395202
122ErbB signaling pathway_Homo sapiens_hsa040120.57180511
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56095104
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55635242
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.54568710
126Melanoma_Homo sapiens_hsa052180.54542226
127Estrogen signaling pathway_Homo sapiens_hsa049150.53546829
128Caffeine metabolism_Homo sapiens_hsa002320.52747315
129VEGF signaling pathway_Homo sapiens_hsa043700.52509390
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.51054736
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50952402
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50729835
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.50628795
134Lysosome_Homo sapiens_hsa041420.49695824
135Platelet activation_Homo sapiens_hsa046110.48318497
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48188010
137Retinol metabolism_Homo sapiens_hsa008300.47059185
138Endometrial cancer_Homo sapiens_hsa052130.46795858
139Insulin resistance_Homo sapiens_hsa049310.46731741
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46581362
141Primary immunodeficiency_Homo sapiens_hsa053400.46485728
142Lysine degradation_Homo sapiens_hsa003100.46445648
143Legionellosis_Homo sapiens_hsa051340.45918249
144Folate biosynthesis_Homo sapiens_hsa007900.45885090
145Fatty acid degradation_Homo sapiens_hsa000710.44790500
146Ras signaling pathway_Homo sapiens_hsa040140.44596655
147mTOR signaling pathway_Homo sapiens_hsa041500.43244683
148Staphylococcus aureus infection_Homo sapiens_hsa051500.42337814
149Chronic myeloid leukemia_Homo sapiens_hsa052200.40416481
150Choline metabolism in cancer_Homo sapiens_hsa052310.40160461
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.38365242
152Inositol phosphate metabolism_Homo sapiens_hsa005620.37957677
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.37754625
154B cell receptor signaling pathway_Homo sapiens_hsa046620.37695971
155Thyroid cancer_Homo sapiens_hsa052160.36088253
156Protein export_Homo sapiens_hsa030600.34497515
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34230990

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