ZFP36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.43705112
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91400324
3negative regulation of cell killing (GO:0031342)4.91400324
4antigen processing and presentation of endogenous antigen (GO:0019883)4.43083891
5microglial cell activation (GO:0001774)4.40353447
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.09650098
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.09650098
8positive regulation by symbiont of host defense response (GO:0052509)4.06055038
9modulation by symbiont of host defense response (GO:0052031)4.06055038
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06055038
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06055038
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.06055038
13modulation by symbiont of host immune response (GO:0052553)4.06055038
14response to muramyl dipeptide (GO:0032495)4.03426773
15regulation of interleukin-12 biosynthetic process (GO:0045075)4.01105928
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.71682391
17regulation of interferon-beta biosynthetic process (GO:0045357)3.71322695
18macrophage activation involved in immune response (GO:0002281)3.69499673
19negative regulation of granulocyte differentiation (GO:0030853)3.67590265
20regulation of B cell receptor signaling pathway (GO:0050855)3.62126028
21detection of other organism (GO:0098543)3.55973632
22positive regulation of gamma-delta T cell activation (GO:0046645)3.52805504
23detection of bacterium (GO:0016045)3.43167732
24G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.40767458
25regulation of germinal center formation (GO:0002634)3.36909860
26mature B cell differentiation (GO:0002335)3.36152504
27immunoglobulin mediated immune response (GO:0016064)3.31532154
28NIK/NF-kappaB signaling (GO:0038061)3.31179000
29germinal center formation (GO:0002467)3.30341898
30positive regulation of antigen processing and presentation (GO:0002579)3.29533858
31cellular extravasation (GO:0045123)3.26566644
32negative thymic T cell selection (GO:0045060)3.24897269
33JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.22653698
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.18419650
35response to interleukin-15 (GO:0070672)3.17698522
36regulation of cellular extravasation (GO:0002691)3.16699107
37negative regulation of interleukin-6 production (GO:0032715)3.13453671
38negative T cell selection (GO:0043383)3.12633543
39macrophage activation (GO:0042116)3.12118974
40positive regulation of B cell differentiation (GO:0045579)3.12085112
41mature B cell differentiation involved in immune response (GO:0002313)3.10253260
42regulation of monocyte differentiation (GO:0045655)3.07192389
43cellular response to interleukin-15 (GO:0071350)3.06611287
44myeloid dendritic cell activation (GO:0001773)3.06410734
45negative regulation of T cell mediated immunity (GO:0002710)3.05865225
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04997252
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04020993
48myeloid dendritic cell differentiation (GO:0043011)3.03515435
49negative regulation of innate immune response (GO:0045824)3.02987777
50regulation of T-helper 2 cell differentiation (GO:0045628)3.00897994
51positive regulation of chemokine secretion (GO:0090197)3.00152713
52positive regulation of interferon-alpha production (GO:0032727)2.99749019
53negative regulation of protein autophosphorylation (GO:0031953)2.97124238
54neutrophil activation involved in immune response (GO:0002283)2.96735300
55defense response to protozoan (GO:0042832)2.96221904
56interleukin-1-mediated signaling pathway (GO:0070498)2.94286078
57detection of external biotic stimulus (GO:0098581)2.92792188
58regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.92022566
59regulation of gamma-delta T cell differentiation (GO:0045586)2.91564156
60definitive hemopoiesis (GO:0060216)2.90938364
61negative regulation of interleukin-1 beta production (GO:0032691)2.89186199
62regulation of B cell differentiation (GO:0045577)2.88042881
63regulation of interferon-alpha production (GO:0032647)2.87399907
64tolerance induction (GO:0002507)2.85966177
65negative regulation of leukocyte mediated immunity (GO:0002704)2.85454546
66regulation of gamma-delta T cell activation (GO:0046643)2.85040638
67germ cell migration (GO:0008354)2.83740230
68negative regulation of T-helper cell differentiation (GO:0045623)2.82144208
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82144208
70T cell selection (GO:0045058)2.81426843
71regulation of chemokine secretion (GO:0090196)2.81358414
72T cell migration (GO:0072678)2.80246520
73response to type I interferon (GO:0034340)2.78620176
74regulation of antigen processing and presentation (GO:0002577)2.78116469
75positive T cell selection (GO:0043368)2.77717735
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77179979
77type I interferon signaling pathway (GO:0060337)2.75561890
78cellular response to type I interferon (GO:0071357)2.75561890
79interferon-gamma-mediated signaling pathway (GO:0060333)2.75415732
80neutrophil activation (GO:0042119)2.75178172
81negative regulation of interleukin-1 production (GO:0032692)2.74837140
82thymic T cell selection (GO:0045061)2.74750756
83detection of biotic stimulus (GO:0009595)2.74188510
84regulation of tolerance induction (GO:0002643)2.74133205
85detection of molecule of bacterial origin (GO:0032490)2.74087190
86regulation of regulatory T cell differentiation (GO:0045589)2.73415399
87positive thymic T cell selection (GO:0045059)2.72835842
88response to laminar fluid shear stress (GO:0034616)2.71200551
89negative regulation of interleukin-8 production (GO:0032717)2.71081813
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70266187
91embryonic process involved in female pregnancy (GO:0060136)2.67646520
92negative regulation of cytokine production involved in immune response (GO:0002719)2.67312134
93regulation of alpha-beta T cell proliferation (GO:0046640)2.66813545
94neutrophil mediated immunity (GO:0002446)2.66664410
95regulation of T cell mediated cytotoxicity (GO:0001914)2.66061332
96dendritic cell differentiation (GO:0097028)2.64063532
97response to peptidoglycan (GO:0032494)2.63747715
98granulocyte activation (GO:0036230)2.63491354
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63254760
100positive regulation of type 2 immune response (GO:0002830)2.63196465
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62486660
102response to host immune response (GO:0052572)2.62486660
103myeloid cell activation involved in immune response (GO:0002275)2.62335350
104response to host (GO:0075136)2.62154324
105response to host defenses (GO:0052200)2.62154324
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62154324
107positive regulation of tolerance induction (GO:0002645)2.61215454
108negative regulation of erythrocyte differentiation (GO:0045647)2.59833376
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59613237
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58472625
111negative regulation of interleukin-12 production (GO:0032695)2.55044177
112positive regulation of p38MAPK cascade (GO:1900745)2.54995970
113response to progesterone (GO:0032570)2.54829437
114B cell receptor signaling pathway (GO:0050853)2.54758494
115leukocyte aggregation (GO:0070486)2.54029341
116regulation of T cell tolerance induction (GO:0002664)2.53667197
117myeloid leukocyte activation (GO:0002274)2.53259188
118regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.53144892
119T cell differentiation involved in immune response (GO:0002292)2.52892366
120alpha-beta T cell differentiation involved in immune response (GO:0002293)2.52892366
121alpha-beta T cell activation involved in immune response (GO:0002287)2.52892366
122interferon-gamma production (GO:0032609)2.52797263
123antigen processing and presentation via MHC class Ib (GO:0002475)2.52417162
124I-kappaB phosphorylation (GO:0007252)2.48166796
125thrombin receptor signaling pathway (GO:0070493)2.47777301
126positive regulation of interleukin-12 production (GO:0032735)2.46700477
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.40573115
128negative regulation of bone resorption (GO:0045779)2.39954446
129cytokine secretion (GO:0050663)2.38991576
130regulation of mast cell degranulation (GO:0043304)2.38718178
131T-helper 1 type immune response (GO:0042088)2.38039114
132growth hormone receptor signaling pathway (GO:0060396)2.38000849
133T-helper cell differentiation (GO:0042093)2.37334377
134CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.37334377
135purinergic nucleotide receptor signaling pathway (GO:0035590)2.36787869
136B cell homeostasis (GO:0001782)2.36136612
137positive regulation of cellular amide metabolic process (GO:0034250)2.35690716
138response to protozoan (GO:0001562)2.34322146
139regulation of interleukin-12 production (GO:0032655)2.34111278
140dendritic cell migration (GO:0036336)2.33545761
141B cell mediated immunity (GO:0019724)2.33297871
142positive regulation of cholesterol efflux (GO:0010875)2.32533260
143radial glial cell differentiation (GO:0060019)2.32449229
144positive regulation of interferon-beta production (GO:0032728)2.32253485
145hepatocyte apoptotic process (GO:0097284)2.31855236
146dendritic cell chemotaxis (GO:0002407)2.31457620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06334031
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.74446172
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.45815154
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.10917717
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93171753
6* EGR1_19374776_ChIP-ChIP_THP-1_Human3.41819475
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.33688110
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.24281141
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22494597
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.17990270
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.09064183
12SCL_19346495_ChIP-Seq_HPC-7_Human3.05656931
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96094208
14RUNX_20019798_ChIP-Seq_JUKART_Human2.81856624
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66408595
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64213065
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63492305
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61737062
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61037422
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56001947
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31541725
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20844827
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.17758663
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10281420
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99219671
26* NOTCH1_21737748_ChIP-Seq_TLL_Human1.97529895
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.95465125
28GATA1_22025678_ChIP-Seq_K562_Human1.87710833
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86997821
30* MAF_26560356_Chip-Seq_TH1_Human1.81204581
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78802652
32* MYB_26560356_Chip-Seq_TH2_Human1.78580626
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.76759138
34* VDR_24763502_ChIP-Seq_THP-1_Human1.69002238
35* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68825009
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63332671
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62773634
38CLOCK_20551151_ChIP-Seq_293T_Human1.60505436
39VDR_24787735_ChIP-Seq_THP-1_Human1.60206720
40* MYB_26560356_Chip-Seq_TH1_Human1.55836551
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.51852676
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.51594445
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.47166846
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46942514
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45503743
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44809457
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43179660
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41755147
49SPI1_23547873_ChIP-Seq_NB4_Human1.41457471
50PU_27001747_Chip-Seq_BMDM_Mouse1.39716102
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39638668
52* VDR_21846776_ChIP-Seq_THP-1_Human1.37925701
53* MAF_26560356_Chip-Seq_TH2_Human1.37057904
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34446346
55SPI1_23127762_ChIP-Seq_K562_Human1.32413943
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31472403
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.30199292
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26353626
59* MYC_22102868_ChIP-Seq_BL_Human1.25165484
60* UTX_26944678_Chip-Seq_JUKART_Human1.23827154
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22627094
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21440754
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21021882
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.20368554
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.19415543
66* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19352016
67* LXR_22292898_ChIP-Seq_THP-1_Human1.18225007
68* GATA3_27048872_Chip-Seq_THYMUS_Human1.17976108
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16309917
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16085776
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15973153
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15973153
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15973153
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15871381
75GATA1_19941826_ChIP-Seq_K562_Human1.15220005
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14988267
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12426019
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.12267223
79* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10966330
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09644340
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09644340
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.09641741
83* GATA2_19941826_ChIP-Seq_K562_Human1.08052623
84* KDM2B_26808549_Chip-Seq_DND41_Human1.07565583
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05476413
86* CJUN_26792858_Chip-Seq_BT549_Human1.05125761
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05083815
88* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04094872
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02420522
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02125665
91* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01027672
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00551349
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00104336
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99991347
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98722403
96* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98519142
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97393255
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96382871
99* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95435490
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93781705
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93719889
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93303659
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92400900
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90282602
105* RXR_22158963_ChIP-Seq_LIVER_Mouse0.90183831
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89967114
107* SOX2_20726797_ChIP-Seq_SW620_Human0.88501376
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88044659
109LXR_22158963_ChIP-Seq_LIVER_Mouse0.87638590
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87543024
111KDM2B_26808549_Chip-Seq_K562_Human0.86595747
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85533901
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85422213
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84148734
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83077778
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82687328
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.82480743
118BCL6_27268052_Chip-Seq_Bcells_Human0.82412925
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82035230
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81796287
121* GATA3_26560356_Chip-Seq_TH2_Human0.81686863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.70798056
2MP0001835_abnormal_antigen_presentation3.47137388
3MP0003303_peritoneal_inflammation2.86921373
4MP0003436_decreased_susceptibility_to2.85462154
5MP0002254_reproductive_system_inflammat2.64736273
6MP0005671_abnormal_response_to2.62537588
7MP0001800_abnormal_humoral_immune2.50490057
8MP0005000_abnormal_immune_tolerance2.48612046
9MP0001790_abnormal_immune_system2.47602920
10MP0005387_immune_system_phenotype2.47602920
11MP0002148_abnormal_hypersensitivity_rea2.47409110
12MP0000685_abnormal_immune_system2.41170122
13MP0004510_myositis2.40769863
14* MP0002419_abnormal_innate_immunity2.39008632
15* MP0002452_abnormal_antigen_presenting2.34908263
16MP0003828_pulmonary_edema2.27962860
17MP0002723_abnormal_immune_serum2.27950320
18MP0003300_gastrointestinal_ulcer2.21179562
19MP0009785_altered_susceptibility_to2.15264679
20MP0009278_abnormal_bone_marrow2.14814246
21MP0005025_abnormal_response_to2.12461218
22MP0002396_abnormal_hematopoietic_system2.08255605
23MP0002166_altered_tumor_susceptibility2.05571213
24MP0006082_CNS_inflammation2.03608841
25MP0001533_abnormal_skeleton_physiology2.00204259
26* MP0001819_abnormal_immune_cell2.00078542
27* MP0002420_abnormal_adaptive_immunity1.99753513
28MP0005464_abnormal_platelet_physiology1.99144294
29MP0003191_abnormal_cellular_cholesterol1.94853449
30MP0002405_respiratory_system_inflammati1.85094967
31MP0001873_stomach_inflammation1.75002767
32* MP0004947_skin_inflammation1.74848654
33MP0010155_abnormal_intestine_physiology1.72784520
34* MP0001851_eye_inflammation1.66471645
35MP0002006_tumorigenesis1.63522440
36MP0003763_abnormal_thymus_physiology1.61824985
37MP0000465_gastrointestinal_hemorrhage1.58596584
38MP0004808_abnormal_hematopoietic_stem1.58573882
39MP0005397_hematopoietic_system_phenotyp1.57832330
40MP0001545_abnormal_hematopoietic_system1.57832330
41MP0000716_abnormal_immune_system1.57719811
42MP0002009_preneoplasia1.55948901
43* MP0001845_abnormal_inflammatory_respons1.55697936
44MP0002398_abnormal_bone_marrow1.55456541
45MP0003453_abnormal_keratinocyte_physiol1.44937756
46* MP0001853_heart_inflammation1.44132465
47MP0002138_abnormal_hepatobiliary_system1.44005041
48MP0002998_abnormal_bone_remodeling1.40142557
49MP0001501_abnormal_sleep_pattern1.37363049
50MP0010368_abnormal_lymphatic_system1.37290599
51MP0003075_altered_response_to1.35655086
52MP0000343_altered_response_to1.33543193
53MP0000689_abnormal_spleen_morphology1.33285853
54MP0005310_abnormal_salivary_gland1.31522935
55MP0003448_altered_tumor_morphology1.30677780
56MP0009764_decreased_sensitivity_to1.28505306
57MP0002277_abnormal_respiratory_mucosa1.28202417
58MP0002429_abnormal_blood_cell1.26979276
59MP0005390_skeleton_phenotype1.26755857
60MP0001879_abnormal_lymphatic_vessel1.25878828
61MP0008469_abnormal_protein_level1.24633401
62* MP0002722_abnormal_immune_system1.24037871
63MP0003566_abnormal_cell_adhesion1.23207321
64MP0001542_abnormal_bone_strength1.20890132
65MP0005023_abnormal_wound_healing1.20764026
66MP0002928_abnormal_bile_duct1.20605236
67MP0008004_abnormal_stomach_pH1.19766904
68MP0003045_fibrosis1.18710108
69MP0003866_abnormal_defecation1.14824705
70MP0000858_altered_metastatic_potential1.12767205
71MP0004782_abnormal_surfactant_physiolog1.12420100
72MP0000249_abnormal_blood_vessel1.06559144
73* MP0002933_joint_inflammation1.06018848
74MP0005058_abnormal_lysosome_morphology1.05760133
75MP0004883_abnormal_blood_vessel1.05347921
76MP0000767_abnormal_smooth_muscle1.05061259
77MP0003279_aneurysm1.02804590
78MP0002060_abnormal_skin_morphology1.00252381
79MP0005076_abnormal_cell_differentiation0.99534968
80MP0010352_gastrointestinal_tract_polyps0.96521049
81* MP0000703_abnormal_thymus_morphology0.94357037
82MP0005164_abnormal_response_to0.93214269
83MP0005257_abnormal_intraocular_pressure0.91322154
84MP0005166_decreased_susceptibility_to0.90432775
85MP0000604_amyloidosis0.88565285
86MP0008961_abnormal_basal_metabolism0.88434183
87MP0001216_abnormal_epidermal_layer0.88035612
88MP0003183_abnormal_peptide_metabolism0.87960062
89MP0009333_abnormal_splenocyte_physiolog0.87318489
90MP0003656_abnormal_erythrocyte_physiolo0.85999795
91MP0003172_abnormal_lysosome_physiology0.85953668
92MP0003690_abnormal_glial_cell0.85681354
93MP0003795_abnormal_bone_structure0.85500352
94MP0005167_abnormal_blood-brain_barrier0.83589551
95MP0003943_abnormal_hepatobiliary_system0.81081688
96MP0002877_abnormal_melanocyte_morpholog0.80494804
97MP0009840_abnormal_foam_cell0.79804171
98MP0001191_abnormal_skin_condition0.79626017
99MP0008260_abnormal_autophagy0.77817444
100MP0005174_abnormal_tail_pigmentation0.77394694
101MP0002132_abnormal_respiratory_system0.76456777
102MP0001958_emphysema0.74104629
103MP0000383_abnormal_hair_follicle0.73774179
104MP0003091_abnormal_cell_migration0.73257190
105MP0006054_spinal_hemorrhage0.73231618
106MP0009763_increased_sensitivity_to0.72557764
107MP0005075_abnormal_melanosome_morpholog0.72050567
108MP0002133_abnormal_respiratory_system0.70915585
109MP0005388_respiratory_system_phenotype0.70915585
110MP0002136_abnormal_kidney_physiology0.70686931
111MP0004381_abnormal_hair_follicle0.68757312
112MP0001663_abnormal_digestive_system0.68385438
113MP0001243_abnormal_dermal_layer0.65172794
114MP0004130_abnormal_muscle_cell0.58801996
115MP0001986_abnormal_taste_sensitivity0.58723376
116MP0008995_early_reproductive_senescence0.57854375
117MP0005535_abnormal_body_temperature0.57732097
118MP0002332_abnormal_exercise_endurance0.56218809
119MP0009115_abnormal_fat_cell0.55871352

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.95227199
2Systemic lupus erythematosus (HP:0002725)4.89187567
3Recurrent abscess formation (HP:0002722)4.49093190
4Recurrent bacterial skin infections (HP:0005406)4.34026384
5Hematochezia (HP:0002573)3.98941380
6Myositis (HP:0100614)3.97144524
7Elevated erythrocyte sedimentation rate (HP:0003565)3.85621143
8Glomerulonephritis (HP:0000099)3.68336805
9Recurrent fungal infections (HP:0002841)3.50520572
10Orchitis (HP:0100796)3.41776977
11Chronic otitis media (HP:0000389)3.40146843
12Recurrent gram-negative bacterial infections (HP:0005420)3.28133336
13Recurrent skin infections (HP:0001581)3.23444869
14Spontaneous hematomas (HP:0007420)3.22352288
15Interstitial pulmonary disease (HP:0006530)3.15151201
16Arterial tortuosity (HP:0005116)3.14694927
17Colitis (HP:0002583)3.11048513
18Aortic aneurysm (HP:0004942)3.05140873
19Gastrointestinal infarctions (HP:0005244)3.04241209
20Chronic mucocutaneous candidiasis (HP:0002728)2.99383611
21Recurrent cutaneous fungal infections (HP:0011370)2.99383611
22Mediastinal lymphadenopathy (HP:0100721)2.91907329
23Cellulitis (HP:0100658)2.89866273
24Chronic diarrhea (HP:0002028)2.87923797
25Vascular tortuosity (HP:0004948)2.87805591
26Prostate neoplasm (HP:0100787)2.87160345
27Retrobulbar optic neuritis (HP:0100654)2.87079644
28Optic neuritis (HP:0100653)2.87079644
29Cerebral aneurysm (HP:0004944)2.83452548
30Inflammation of the large intestine (HP:0002037)2.82072035
31Periodontitis (HP:0000704)2.80176856
32T lymphocytopenia (HP:0005403)2.79455333
33Encephalitis (HP:0002383)2.76372666
34Complement deficiency (HP:0004431)2.75460748
35Myocardial infarction (HP:0001658)2.73078316
36Abnormality of T cell number (HP:0011839)2.71212164
37Abnormality of macrophages (HP:0004311)2.70316593
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.69904523
39Recurrent viral infections (HP:0004429)2.68727537
40Pustule (HP:0200039)2.68296571
41Episodic fever (HP:0001954)2.66323219
42Increased cerebral lipofuscin (HP:0011813)2.65607486
43Arterial thrombosis (HP:0004420)2.63264856
44Gingival bleeding (HP:0000225)2.61711693
45Vasculitis (HP:0002633)2.60760713
46Prolonged bleeding time (HP:0003010)2.59796558
47Gastrointestinal inflammation (HP:0004386)2.57477041
48Abnormality of the nasal mucosa (HP:0000433)2.57184031
49IgM deficiency (HP:0002850)2.56959884
50Abnormality of T cells (HP:0002843)2.51228091
51Abnormality of glycolipid metabolism (HP:0010969)2.47153520
52Abnormality of liposaccharide metabolism (HP:0010968)2.47153520
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.47153520
54Leukocytosis (HP:0001974)2.46975478
55Thick nail (HP:0001805)2.46975118
56Abnormal platelet function (HP:0011869)2.45795676
57Impaired platelet aggregation (HP:0003540)2.45795676
58Eosinophilia (HP:0001880)2.43964856
59Hypergammaglobulinemia (HP:0010702)2.43948176
60Increased IgE level (HP:0003212)2.43709597
61Epistaxis (HP:0000421)2.43500667
62Chest pain (HP:0100749)2.43485643
63Gingivitis (HP:0000230)2.43027619
64Papilledema (HP:0001085)2.42895850
65Axonal loss (HP:0003447)2.39593621
66Urticaria (HP:0001025)2.39085882
67Pulmonary infiltrates (HP:0002113)2.38152193
68Thrombocytosis (HP:0001894)2.36301287
69Gangrene (HP:0100758)2.35560614
70Abnormality of the pleura (HP:0002103)2.35440709
71Agammaglobulinemia (HP:0004432)2.33446770
72Meningitis (HP:0001287)2.33297581
73Pulmonary embolism (HP:0002204)2.33010654
74Nephritis (HP:0000123)2.32950889
75Alveolar cell carcinoma (HP:0006519)2.30205676
76Abnormality of T cell physiology (HP:0011840)2.29126017
77Cheilitis (HP:0100825)2.27607532
78Abnormality of complement system (HP:0005339)2.26724458
79Petechiae (HP:0000967)2.26723979
80Vacuolated lymphocytes (HP:0001922)2.26461223
81Hemoptysis (HP:0002105)2.24671610
82Aortic dissection (HP:0002647)2.24420250
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.23954039
84Osteolytic defects of the hand bones (HP:0009699)2.23954039
85Dysostosis multiplex (HP:0000943)2.23788760
86Spondylolisthesis (HP:0003302)2.23241608
87Glomerulopathy (HP:0100820)2.23025252
88Joint swelling (HP:0001386)2.22986995
89Osteomyelitis (HP:0002754)2.21137465
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.21103952
91Acute myeloid leukemia (HP:0004808)2.20302620
92Premature loss of primary teeth (HP:0006323)2.19814378
93Autoimmune thrombocytopenia (HP:0001973)2.19571605
94IgG deficiency (HP:0004315)2.19176127
95Nasal polyposis (HP:0100582)2.18671589
96Segmental peripheral demyelination/remyelination (HP:0003481)2.17890617
97Malnutrition (HP:0004395)2.15525434
98Abnormality of eosinophils (HP:0001879)2.15365365
99Anorexia (HP:0002039)2.14962275
100Autoimmune hemolytic anemia (HP:0001890)2.14731555
101Increased IgM level (HP:0003496)2.14097942
102Neoplasm of the tracheobronchial system (HP:0100552)2.13036644
103Recurrent bronchitis (HP:0002837)2.11622197
104Stomatitis (HP:0010280)2.09884688
105Obstructive lung disease (HP:0006536)2.08443186
106Chronic obstructive pulmonary disease (HP:0006510)2.08443186
107Stomach cancer (HP:0012126)2.06215713
108Anhidrosis (HP:0000970)2.06161698
109Vertigo (HP:0002321)2.05106558
110Panhypogammaglobulinemia (HP:0003139)2.03990840
111Granulocytopenia (HP:0001913)2.02751334
112Keratoconjunctivitis sicca (HP:0001097)2.01566726
113Amyloidosis (HP:0011034)2.00651365
114Keratoconjunctivitis (HP:0001096)2.00412924
115Abnormality of the nasal septum (HP:0000419)1.97852224
116Increased serum ferritin (HP:0003281)1.97614202
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97409428
118Abnormality of polysaccharide metabolism (HP:0011012)1.97409428
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97409428
120Asymmetric septal hypertrophy (HP:0001670)1.97200964
121Growth hormone excess (HP:0000845)1.97088893
122Acne (HP:0001061)1.96796717
123Papilloma (HP:0012740)1.96538011
124Verrucae (HP:0200043)1.96538011
125Skin ulcer (HP:0200042)1.96420678
126Emphysema (HP:0002097)1.95754631
127Gastrointestinal stroma tumor (HP:0100723)1.94518274
128Vertebral compression fractures (HP:0002953)1.94011740
129Abnormality of the prostate (HP:0008775)1.92854983
130Milia (HP:0001056)1.91059009
131Abnormality of the fingertips (HP:0001211)1.90953822
132Recurrent pneumonia (HP:0006532)1.88440652
133Striae distensae (HP:0001065)1.88085353
134Persistence of primary teeth (HP:0006335)1.86945331
135Thyroiditis (HP:0100646)1.86862013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.88106143
2MAPK154.67602722
3MAP3K143.16244816
4MAP4K12.49307613
5TYK22.46500603
6GRK62.41605363
7TBK12.30855420
8IKBKB2.29302443
9GRK72.12839727
10PRPF4B2.10993893
11IRAK42.04309304
12ERN11.98692192
13IKBKE1.97227691
14EPHB11.96473957
15MAP2K21.95225638
16KIT1.86987573
17TXK1.83025842
18STK101.82353211
19IRAK31.75901995
20CSF1R1.73673661
21ITK1.66943899
22JAK31.61919883
23JAK11.59630597
24EPHA31.58761437
25CHUK1.58350248
26TIE11.56604570
27ZAP701.49632762
28BLK1.46095971
29TNK21.44747761
30RIPK41.42670134
31FGFR41.38885767
32TEC1.35194029
33MAP3K31.32846191
34MAP2K31.28122128
35BTK1.27893335
36NLK1.24456944
37RIPK11.24148215
38SIK31.23888043
39BMPR21.21550663
40VRK11.21158195
41PIM21.20508561
42CSK1.18623899
43MAPK71.18001152
44TSSK61.16908898
45RPS6KA41.14590261
46MAP3K131.13763994
47MAP3K111.12065372
48KDR1.10318708
49FGFR31.07929513
50MAP3K11.00715328
51TAOK11.00489314
52HCK0.98840907
53MARK20.97386873
54TGFBR10.96085524
55MAPKAPK50.94949504
56CDC42BPA0.94927368
57MATK0.94801902
58JAK20.92670490
59LCK0.91367628
60CAMK1D0.91058899
61TESK20.90354506
62TRIB30.88333574
63SIK10.87973194
64TAOK30.87520058
65NEK90.85772739
66PRKD20.85706569
67FLT30.84858164
68SYK0.84587160
69PIM10.84194763
70MAP3K70.83154469
71IRAK10.81579709
72LYN0.77039209
73EIF2AK20.75668612
74IRAK20.75426549
75TAOK20.75032008
76CDK120.74260288
77MARK30.74177021
78CDK30.72890949
79PTK60.71772581
80PDK10.68486328
81HIPK20.68350778
82GSK3A0.68024808
83MAP3K100.67771762
84CDK60.67606366
85PIK3CG0.66156032
86CDK90.62885992
87MOS0.59782117
88FGR0.59541393
89RPS6KA60.59233751
90SIK20.58175612
91PAK20.58169016
92* MAPKAPK20.57599869
93MAPK120.56892459
94CLK10.56631626
95PDPK10.54646204
96RPS6KA50.53878399
97ADRBK20.50435041
98BMPR1B0.49330896
99CAMK1G0.48716990
100RPS6KA10.47713726
101RPS6KC10.46826147
102RPS6KL10.46826147
103MST40.45861027
104FES0.45356696
105LRRK20.44824853
106TRPM70.44471104
107NUAK10.44407637
108PRKAA20.44351465
109* MAPK30.44015483
110ABL10.43141517
111PRKD10.43117964
112IGF1R0.42488115
113PDGFRB0.41379116
114RPS6KA20.39874440
115PRKCQ0.39684455
116PAK40.39082541
117MAP3K60.38044254
118EEF2K0.36982131
119DMPK0.36681558
120CAMK40.35945667
121FYN0.35873926
122PRKG20.35035530
123DYRK1B0.33425033
124PDK20.33090210
125SGK30.32923598
126CDK80.32873481
127* MAPK40.32709773
128PTK2B0.32581349
129SGK20.30839825
130RET0.29272699

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.16787186
2Osteoclast differentiation_Homo sapiens_hsa043803.04538538
3Staphylococcus aureus infection_Homo sapiens_hsa051502.71618857
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.63181411
5B cell receptor signaling pathway_Homo sapiens_hsa046622.48036522
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34322618
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25632484
8Pertussis_Homo sapiens_hsa051332.10827407
9TNF signaling pathway_Homo sapiens_hsa046682.05719982
10Toxoplasmosis_Homo sapiens_hsa051451.97410976
11Antigen processing and presentation_Homo sapiens_hsa046121.94325774
12Measles_Homo sapiens_hsa051621.86075310
13Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.83507391
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82007389
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.76005899
16Malaria_Homo sapiens_hsa051441.73603976
17Hematopoietic cell lineage_Homo sapiens_hsa046401.68293446
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.63440880
19Primary immunodeficiency_Homo sapiens_hsa053401.63311187
20Legionellosis_Homo sapiens_hsa051341.62837477
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61454345
22Influenza A_Homo sapiens_hsa051641.59349862
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.53399612
24Type I diabetes mellitus_Homo sapiens_hsa049401.47766689
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47567806
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46911436
27Apoptosis_Homo sapiens_hsa042101.46633244
28T cell receptor signaling pathway_Homo sapiens_hsa046601.46332907
29Herpes simplex infection_Homo sapiens_hsa051681.41598927
30Other glycan degradation_Homo sapiens_hsa005111.36866146
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.35816200
32Hepatitis B_Homo sapiens_hsa051611.34202516
33Tuberculosis_Homo sapiens_hsa051521.34199299
34Acute myeloid leukemia_Homo sapiens_hsa052211.30010556
35African trypanosomiasis_Homo sapiens_hsa051431.26238505
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25921152
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23342470
38Chronic myeloid leukemia_Homo sapiens_hsa052201.22241672
39Complement and coagulation cascades_Homo sapiens_hsa046101.21922108
40Rheumatoid arthritis_Homo sapiens_hsa053231.21797277
41Chemokine signaling pathway_Homo sapiens_hsa040621.20754453
42Salmonella infection_Homo sapiens_hsa051321.16759932
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14652186
44Lysosome_Homo sapiens_hsa041421.14440476
45Platelet activation_Homo sapiens_hsa046111.11375525
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06913086
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06391380
48Hepatitis C_Homo sapiens_hsa051601.05758773
49Shigellosis_Homo sapiens_hsa051311.04003484
50Graft-versus-host disease_Homo sapiens_hsa053321.03906756
51Small cell lung cancer_Homo sapiens_hsa052221.03703732
52Prolactin signaling pathway_Homo sapiens_hsa049171.01809882
53Pancreatic cancer_Homo sapiens_hsa052120.97624398
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94439302
55Notch signaling pathway_Homo sapiens_hsa043300.89995359
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89085490
57Allograft rejection_Homo sapiens_hsa053300.87327803
58Amoebiasis_Homo sapiens_hsa051460.85409568
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84408236
60Colorectal cancer_Homo sapiens_hsa052100.81329366
61Prion diseases_Homo sapiens_hsa050200.79280736
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.75013589
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.73626646
64* HTLV-I infection_Homo sapiens_hsa051660.72588406
65Insulin resistance_Homo sapiens_hsa049310.69954588
66ABC transporters_Homo sapiens_hsa020100.67652945
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65288283
68Adherens junction_Homo sapiens_hsa045200.65004116
69MAPK signaling pathway_Homo sapiens_hsa040100.64839863
70Choline metabolism in cancer_Homo sapiens_hsa052310.63815272
71Caffeine metabolism_Homo sapiens_hsa002320.63404657
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61941942
73Non-small cell lung cancer_Homo sapiens_hsa052230.61464859
74Epstein-Barr virus infection_Homo sapiens_hsa051690.60413791
75Circadian rhythm_Homo sapiens_hsa047100.60141652
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.59494700
77Pathways in cancer_Homo sapiens_hsa052000.59119421
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58476275
79GnRH signaling pathway_Homo sapiens_hsa049120.58258954
80Viral myocarditis_Homo sapiens_hsa054160.57136861
81Asthma_Homo sapiens_hsa053100.57133933
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56180949
83FoxO signaling pathway_Homo sapiens_hsa040680.56018576
84Focal adhesion_Homo sapiens_hsa045100.55098811
85Arachidonic acid metabolism_Homo sapiens_hsa005900.54204945
86Prostate cancer_Homo sapiens_hsa052150.53895850
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.53744848
88ECM-receptor interaction_Homo sapiens_hsa045120.53481508
89Viral carcinogenesis_Homo sapiens_hsa052030.53252062
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51940861
91Proteoglycans in cancer_Homo sapiens_hsa052050.49793772
92TGF-beta signaling pathway_Homo sapiens_hsa043500.48255999
93Phagosome_Homo sapiens_hsa041450.46140098
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46061490
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45598214
96VEGF signaling pathway_Homo sapiens_hsa043700.44659338
97Type II diabetes mellitus_Homo sapiens_hsa049300.44540395
98MicroRNAs in cancer_Homo sapiens_hsa052060.44013478
99Rap1 signaling pathway_Homo sapiens_hsa040150.43187706
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41052463
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39374846
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39312996
103Endocytosis_Homo sapiens_hsa041440.39274935
104HIF-1 signaling pathway_Homo sapiens_hsa040660.38930968
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.38774617
106Renal cell carcinoma_Homo sapiens_hsa052110.38425448
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38283605
108Dorso-ventral axis formation_Homo sapiens_hsa043200.38096207
109Renin secretion_Homo sapiens_hsa049240.37861372
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37053134
111Estrogen signaling pathway_Homo sapiens_hsa049150.36512051
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34945511
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33933435
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.33534360
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33430848
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.33329739
117Autoimmune thyroid disease_Homo sapiens_hsa053200.32817330
118mTOR signaling pathway_Homo sapiens_hsa041500.30564709
119Ovarian steroidogenesis_Homo sapiens_hsa049130.29747822
120Inositol phosphate metabolism_Homo sapiens_hsa005620.27243330

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