ZFP36L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22244213
2negative regulation of cell killing (GO:0031342)5.22244213
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39943998
4positive thymic T cell selection (GO:0045059)3.70367839
5tolerance induction (GO:0002507)3.56501266
6regulation of interleukin-12 biosynthetic process (GO:0045075)3.49217904
7regulation of gamma-delta T cell differentiation (GO:0045586)3.40784051
8lung lobe morphogenesis (GO:0060463)3.30925676
9positive regulation by symbiont of host defense response (GO:0052509)3.21151437
10modulation by symbiont of host defense response (GO:0052031)3.21151437
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21151437
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21151437
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.21151437
14modulation by symbiont of host immune response (GO:0052553)3.21151437
15growth hormone receptor signaling pathway (GO:0060396)3.19145545
16regulation of T cell tolerance induction (GO:0002664)3.07423188
17antigen processing and presentation of endogenous antigen (GO:0019883)3.05949193
18regulation of gamma-delta T cell activation (GO:0046643)3.05039874
19regulation of T cell mediated cytotoxicity (GO:0001914)3.03980366
20radial glial cell differentiation (GO:0060019)3.01017453
21thymic T cell selection (GO:0045061)3.00264295
22regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97164986
23negative thymic T cell selection (GO:0045060)2.97040635
24positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95833372
25pattern specification involved in kidney development (GO:0061004)2.93393397
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92120050
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92120050
28detection of other organism (GO:0098543)2.91688629
29detection of bacterium (GO:0016045)2.91618202
30negative regulation of lymphocyte mediated immunity (GO:0002707)2.90523228
31cellular response to growth hormone stimulus (GO:0071378)2.90205126
32response to type I interferon (GO:0034340)2.86184800
33cell migration involved in sprouting angiogenesis (GO:0002042)2.85572266
34lateral sprouting from an epithelium (GO:0060601)2.83268835
35heart valve formation (GO:0003188)2.81502067
36positive regulation of tolerance induction (GO:0002645)2.80794439
37negative T cell selection (GO:0043383)2.78811357
38regulation of interferon-beta biosynthetic process (GO:0045357)2.78060079
39type I interferon signaling pathway (GO:0060337)2.76757686
40cellular response to type I interferon (GO:0071357)2.76757686
41positive regulation of astrocyte differentiation (GO:0048711)2.74009811
42lymph vessel development (GO:0001945)2.72595321
43positive regulation of p38MAPK cascade (GO:1900745)2.72469702
44endothelial cell chemotaxis (GO:0035767)2.71170215
45regulation of monocyte differentiation (GO:0045655)2.70813175
46response to laminar fluid shear stress (GO:0034616)2.69993344
47cell proliferation involved in kidney development (GO:0072111)2.67394369
48regulation of B cell receptor signaling pathway (GO:0050855)2.63575218
49negative regulation of T cell mediated immunity (GO:0002710)2.62674747
50dendritic cell chemotaxis (GO:0002407)2.61106372
51regulation of tolerance induction (GO:0002643)2.60911429
52positive regulation of gamma-delta T cell activation (GO:0046645)2.59418253
53Notch signaling involved in heart development (GO:0061314)2.59271271
54NIK/NF-kappaB signaling (GO:0038061)2.59095463
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58162217
56macrophage activation involved in immune response (GO:0002281)2.57241456
57blood vessel endothelial cell migration (GO:0043534)2.56970700
58hypotonic response (GO:0006971)2.54841624
59positive T cell selection (GO:0043368)2.52937642
60CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.50704763
61T-helper cell differentiation (GO:0042093)2.50704763
62detection of external biotic stimulus (GO:0098581)2.50512515
63cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50455576
64regulation of p38MAPK cascade (GO:1900744)2.50267004
65negative regulation of leukocyte mediated immunity (GO:0002704)2.49620680
66positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49279294
67positive regulation of fatty acid beta-oxidation (GO:0032000)2.48232569
68response to muramyl dipeptide (GO:0032495)2.47541484
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45257911
70vascular endothelial growth factor signaling pathway (GO:0038084)2.45244102
71cell proliferation involved in metanephros development (GO:0072203)2.44737997
72regulation of leukocyte mediated cytotoxicity (GO:0001910)2.43935395
73T-helper 1 type immune response (GO:0042088)2.41588103
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41056652
75response to host (GO:0075136)2.41056652
76response to host defenses (GO:0052200)2.41056652
77negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40187549
78regulation of cholesterol homeostasis (GO:2000188)2.38318986
79negative regulation of innate immune response (GO:0045824)2.37580530
80microglial cell activation (GO:0001774)2.36238565
81T cell selection (GO:0045058)2.35729823
82surfactant homeostasis (GO:0043129)2.34646262
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33523776
84positive regulation of T cell differentiation in thymus (GO:0033089)2.33440087
85germ cell migration (GO:0008354)2.32346265
86positive regulation of epithelial to mesenchymal transition (GO:0010718)2.31868424
87germinal center formation (GO:0002467)2.31140051
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.30906810
89positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.30317789
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29589605
91regulation of regulatory T cell differentiation (GO:0045589)2.28998326
92regulation of cell killing (GO:0031341)2.28232697
93response to interleukin-15 (GO:0070672)2.27460773
94interferon-gamma-mediated signaling pathway (GO:0060333)2.27215595
95patterning of blood vessels (GO:0001569)2.25694228
96dendritic cell migration (GO:0036336)2.25520655
97detection of biotic stimulus (GO:0009595)2.24639523
98regulation of natural killer cell mediated immunity (GO:0002715)2.23719199
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.23719199
100epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.23486999
101negative regulation of granulocyte differentiation (GO:0030853)2.22901741
102detection of molecule of bacterial origin (GO:0032490)2.22830269
103regulation of extracellular matrix disassembly (GO:0010715)2.22814721
104regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21954756
105response to host immune response (GO:0052572)2.21742094
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21742094
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.20718647
108positive regulation of cell killing (GO:0031343)2.19798104
109peptidyl-glutamic acid carboxylation (GO:0017187)2.19052187
110protein carboxylation (GO:0018214)2.19052187
111positive regulation of histone deacetylation (GO:0031065)2.18371210
112renal system development (GO:0072001)2.16902860
113positive regulation of cholesterol efflux (GO:0010875)2.16891616
114interferon-gamma secretion (GO:0072643)2.15962819
115endocardial cushion morphogenesis (GO:0003203)2.15874739
116negative regulation of protein autophosphorylation (GO:0031953)2.15355040
117alpha-beta T cell differentiation involved in immune response (GO:0002293)2.14989113
118alpha-beta T cell activation involved in immune response (GO:0002287)2.14989113
119T cell differentiation involved in immune response (GO:0002292)2.14989113
120atrioventricular valve morphogenesis (GO:0003181)2.14005177
121nephron tubule formation (GO:0072079)2.13711918
122negative regulation of cholesterol transport (GO:0032375)2.13125535
123negative regulation of sterol transport (GO:0032372)2.13125535
124antigen processing and presentation via MHC class Ib (GO:0002475)2.12889254
125neutrophil activation (GO:0042119)2.12230503
126negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.11703592
127positive regulation of endothelial cell apoptotic process (GO:2000353)2.11400056
128positive regulation of Notch signaling pathway (GO:0045747)2.10743967
129lung vasculature development (GO:0060426)2.10365654
130regulation of extracellular matrix organization (GO:1903053)2.09810115
131face development (GO:0060324)2.09068506
132mesenchyme morphogenesis (GO:0072132)2.07828997
133positive regulation of cholesterol transport (GO:0032376)2.07461904
134positive regulation of sterol transport (GO:0032373)2.07461904
135interferon-gamma production (GO:0032609)2.06541071
136pathway-restricted SMAD protein phosphorylation (GO:0060389)2.05942876
137positive regulation of extracellular matrix organization (GO:1903055)2.05425005
138negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.05145734
139response to fluid shear stress (GO:0034405)2.04727981
140endothelial tube morphogenesis (GO:0061154)2.03143161
141morphogenesis of an endothelium (GO:0003159)2.03143161
142cell surface receptor signaling pathway involved in heart development (GO:0061311)2.02522793
143tyrosine phosphorylation of STAT protein (GO:0007260)2.02181250
144hippo signaling (GO:0035329)2.02142372
145hemidesmosome assembly (GO:0031581)2.01982229
146glomerular filtration (GO:0003094)2.01169537
147coronary vasculature morphogenesis (GO:0060977)2.00679427
148negative regulation of fatty acid transport (GO:2000192)2.00557107
149regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.00321217
150mesodermal cell differentiation (GO:0048333)1.99802594
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.98888578
152cellular response to interleukin-15 (GO:0071350)1.97896867
153planar cell polarity pathway involved in neural tube closure (GO:0090179)1.97633991
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.97580684
155renal filtration (GO:0097205)1.96198528
156basement membrane organization (GO:0071711)1.96155476
157glomerular basement membrane development (GO:0032836)1.95924652
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.95580892
159response to nitrosative stress (GO:0051409)1.95017060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.28886523
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.97402079
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.89035742
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66648950
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.50883556
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.08759115
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06538797
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.99014658
9* CLOCK_20551151_ChIP-Seq_293T_Human2.76362358
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.67718745
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50716207
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.45796686
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.39467423
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35965293
15* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35261517
16RUNX_20019798_ChIP-Seq_JUKART_Human2.30134220
17* LXR_22158963_ChIP-Seq_LIVER_Mouse2.28910248
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.15931073
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06329111
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.97727479
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95260894
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81943541
23MYC_22102868_ChIP-Seq_BL_Human1.79982057
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76803710
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76258178
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76117310
27* TCF7_22412390_ChIP-Seq_EML_Mouse1.74331943
28* MAF_26560356_Chip-Seq_TH1_Human1.73813083
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69237456
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.69058775
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.67821730
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67093257
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.65085518
34* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64911541
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64004681
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59729474
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59363841
38* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58430228
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.56961742
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51030211
41MYB_26560356_Chip-Seq_TH2_Human1.50536345
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50308172
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49907303
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46997909
45* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45365913
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44220600
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44207307
48KDM2B_26808549_Chip-Seq_DND41_Human1.43915847
49* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40397746
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.40205143
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39475322
52* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39357691
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38259521
54LXR_22292898_ChIP-Seq_THP-1_Human1.38139716
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.37086550
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34659569
57* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34448066
58* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34448066
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34175063
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.33809383
61* MYB_26560356_Chip-Seq_TH1_Human1.33020861
62* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33004592
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30465354
64VDR_21846776_ChIP-Seq_THP-1_Human1.29803287
65VDR_24787735_ChIP-Seq_THP-1_Human1.28724871
66* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28676467
67* CJUN_26792858_Chip-Seq_BT549_Human1.26169871
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26061448
69* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24863435
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24769484
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24692626
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.24677163
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23428469
74* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18109384
75* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17100592
76* UTX_26944678_Chip-Seq_JUKART_Human1.16579975
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16412737
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16412737
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16412737
80* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15499570
81VDR_24763502_ChIP-Seq_THP-1_Human1.15321606
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15308342
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12780299
84SCL_19346495_ChIP-Seq_HPC-7_Human1.11879972
85* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11623940
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10372496
87KDM2B_26808549_Chip-Seq_K562_Human1.09732685
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09153537
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.08430911
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08193244
91* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08034605
92* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08034605
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.07605157
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07460953
95* MAF_26560356_Chip-Seq_TH2_Human1.07353554
96* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07301597
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05809425
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04091685
99* RACK7_27058665_Chip-Seq_MCF-7_Human1.03350912
100* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02327023
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98581532
102* ESR1_20079471_ChIP-ChIP_T-47D_Human0.98353683
103* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98203718
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96811029
105* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96644032
106* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96393033
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94622222
108* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94534467
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94337419
110* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93271265
111SPI1_23127762_ChIP-Seq_K562_Human0.92459998
112* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91576318
113NCOR1_26117541_ChIP-Seq_K562_Human0.90674574
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90227777
115* BRD4_25478319_ChIP-Seq_HGPS_Human0.89908373
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89704785
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.86140720
118* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84901209
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84692820
120* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84117951
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81983451
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78501901
123RXR_22108803_ChIP-Seq_LS180_Human0.78315840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.07782935
2MP0002138_abnormal_hepatobiliary_system2.49150872
3MP0000566_synostosis2.43834381
4MP0003300_gastrointestinal_ulcer2.39131799
5MP0003303_peritoneal_inflammation2.10181095
6MP0003724_increased_susceptibility_to2.09209962
7MP0003705_abnormal_hypodermis_morpholog2.08665321
8MP0010368_abnormal_lymphatic_system2.01087787
9MP0000685_abnormal_immune_system1.96281070
10MP0001790_abnormal_immune_system1.86487913
11MP0005387_immune_system_phenotype1.86487913
12MP0003136_yellow_coat_color1.84046901
13MP0002166_altered_tumor_susceptibility1.82355984
14MP0001879_abnormal_lymphatic_vessel1.79460222
15MP0003436_decreased_susceptibility_to1.73242701
16MP0003763_abnormal_thymus_physiology1.70053826
17MP0001835_abnormal_antigen_presentation1.69054065
18MP0005076_abnormal_cell_differentiation1.68774816
19MP0002653_abnormal_ependyma_morphology1.67164513
20MP0001800_abnormal_humoral_immune1.64449779
21MP0008438_abnormal_cutaneous_collagen1.63972400
22MP0003453_abnormal_keratinocyte_physiol1.62600560
23MP0009053_abnormal_anal_canal1.62482544
24MP0002009_preneoplasia1.58963536
25MP0001853_heart_inflammation1.58324322
26MP0003279_aneurysm1.57114860
27MP0002405_respiratory_system_inflammati1.55651444
28MP0005360_urolithiasis1.51639568
29MP0003252_abnormal_bile_duct1.48533852
30MP0003828_pulmonary_edema1.48493296
31MP0009278_abnormal_bone_marrow1.47841161
32MP0003566_abnormal_cell_adhesion1.47447160
33MP0005023_abnormal_wound_healing1.47035518
34MP0004272_abnormal_basement_membrane1.45638002
35MP0009384_cardiac_valve_regurgitation1.44698686
36MP0005164_abnormal_response_to1.44549193
37MP0005275_abnormal_skin_tensile1.42865264
38MP0004947_skin_inflammation1.38976449
39MP0010155_abnormal_intestine_physiology1.36259754
40MP0001873_stomach_inflammation1.36210887
41MP0005671_abnormal_response_to1.35775026
42MP0000767_abnormal_smooth_muscle1.32857980
43MP0003191_abnormal_cellular_cholesterol1.32838217
44MP0005000_abnormal_immune_tolerance1.32102864
45MP0004510_myositis1.31315034
46MP0002452_abnormal_antigen_presenting1.31294899
47MP0004858_abnormal_nervous_system1.30073983
48MP0002006_tumorigenesis1.29755788
49MP0000762_abnormal_tongue_morphology1.29169083
50MP0002060_abnormal_skin_morphology1.26510141
51MP0010352_gastrointestinal_tract_polyps1.25689670
52MP0002723_abnormal_immune_serum1.22137650
53MP0005377_hearing/vestibular/ear_phenot1.22057316
54MP0003878_abnormal_ear_physiology1.22057316
55MP0002933_joint_inflammation1.20692216
56MP0002139_abnormal_hepatobiliary_system1.20102443
57MP0001851_eye_inflammation1.16860387
58MP0001533_abnormal_skeleton_physiology1.13514145
59MP0003045_fibrosis1.13171067
60MP0006054_spinal_hemorrhage1.13010982
61MP0005365_abnormal_bile_salt1.11687723
62MP0002133_abnormal_respiratory_system1.10942731
63MP0005388_respiratory_system_phenotype1.10942731
64MP0005503_abnormal_tendon_morphology1.10868377
65MP0009333_abnormal_splenocyte_physiolog1.10403729
66MP0001216_abnormal_epidermal_layer1.07656004
67MP0002420_abnormal_adaptive_immunity1.07308869
68MP0005085_abnormal_gallbladder_physiolo1.06154155
69MP0001819_abnormal_immune_cell1.05989459
70MP0003091_abnormal_cell_migration1.05872285
71MP0010234_abnormal_vibrissa_follicle1.05325377
72MP0000858_altered_metastatic_potential1.03377620
73MP0000383_abnormal_hair_follicle1.02693833
74MP0009785_altered_susceptibility_to1.02486912
75MP0001243_abnormal_dermal_layer1.02215989
76MP0002282_abnormal_trachea_morphology1.01424699
77MP0008875_abnormal_xenobiotic_pharmacok0.99921578
78MP0000249_abnormal_blood_vessel0.99213364
79MP0002419_abnormal_innate_immunity0.98826516
80MP0000609_abnormal_liver_physiology0.98163985
81MP0000733_abnormal_muscle_development0.97016356
82MP0005025_abnormal_response_to0.95974541
83MP0002098_abnormal_vibrissa_morphology0.95285037
84MP0001845_abnormal_inflammatory_respons0.95210992
85MP0001542_abnormal_bone_strength0.95026505
86MP0001958_emphysema0.94792803
87MP0003795_abnormal_bone_structure0.94410323
88MP0005390_skeleton_phenotype0.94179851
89MP0003941_abnormal_skin_development0.93147920
90MP0002998_abnormal_bone_remodeling0.92969563
91MP0005508_abnormal_skeleton_morphology0.92939350
92MP0003866_abnormal_defecation0.92507334
93MP0004808_abnormal_hematopoietic_stem0.91496521
94MP0001348_abnormal_lacrimal_gland0.91383301
95MP0001849_ear_inflammation0.90480918
96MP0002148_abnormal_hypersensitivity_rea0.90474958
97MP0008961_abnormal_basal_metabolism0.90045981
98MP0000465_gastrointestinal_hemorrhage0.88346277
99MP0004883_abnormal_blood_vessel0.88198429
100MP0000716_abnormal_immune_system0.88018127
101MP0010678_abnormal_skin_adnexa0.86132186
102MP0002928_abnormal_bile_duct0.86125269
103MP0002249_abnormal_larynx_morphology0.85938181
104MP0009764_decreased_sensitivity_to0.85351364
105MP0005623_abnormal_meninges_morphology0.85333965
106MP0002398_abnormal_bone_marrow0.84765695
107MP0004264_abnormal_extraembryonic_tissu0.83936807
108MP0005248_abnormal_Harderian_gland0.83522608
109MP0006138_congestive_heart_failure0.83497177
110MP0000703_abnormal_thymus_morphology0.83217741
111MP0002796_impaired_skin_barrier0.83001615
112MP0005257_abnormal_intraocular_pressure0.82420234
113MP0002136_abnormal_kidney_physiology0.82338585
114MP0010329_abnormal_lipoprotein_level0.82034939
115MP0003448_altered_tumor_morphology0.81965498
116MP0002277_abnormal_respiratory_mucosa0.81929833
117MP0001663_abnormal_digestive_system0.81476345
118MP0004381_abnormal_hair_follicle0.81398459
119MP0010030_abnormal_orbit_morphology0.81201170
120* MP0002429_abnormal_blood_cell0.80729368
121MP0006082_CNS_inflammation0.80687327
122MP0002722_abnormal_immune_system0.80656898
123MP0003075_altered_response_to0.80594257
124MP0001915_intracranial_hemorrhage0.79915189
125MP0008469_abnormal_protein_level0.79045469
126MP0002108_abnormal_muscle_morphology0.78392607
127MP0000689_abnormal_spleen_morphology0.78335432
128MP0000537_abnormal_urethra_morphology0.77986962

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)3.76521191
2Myocardial infarction (HP:0001658)3.47007150
3Aortic aneurysm (HP:0004942)3.26633798
4Bronchomalacia (HP:0002780)3.16024352
5Supernumerary ribs (HP:0005815)3.13003397
6Aortic dissection (HP:0002647)3.07681561
7Esophageal varix (HP:0002040)3.00783045
8Supernumerary bones of the axial skeleton (HP:0009144)2.87250333
9Conical tooth (HP:0000698)2.85268835
10Cerebral aneurysm (HP:0004944)2.84616698
11Persistence of primary teeth (HP:0006335)2.82279954
12Protrusio acetabuli (HP:0003179)2.81585793
13Orchitis (HP:0100796)2.77842454
14Abnormality of incisor morphology (HP:0011063)2.75584487
15Deep venous thrombosis (HP:0002625)2.73416196
16Complement deficiency (HP:0004431)2.69314261
17Hematochezia (HP:0002573)2.60740311
18Polycythemia (HP:0001901)2.60645715
19Eczematoid dermatitis (HP:0000976)2.59866709
20Arterial tortuosity (HP:0005116)2.57836459
21Myositis (HP:0100614)2.52846681
22Abnormality of the parietal bone (HP:0002696)2.52579585
23Elevated erythrocyte sedimentation rate (HP:0003565)2.51487312
24Mitral valve prolapse (HP:0001634)2.51241156
25Xerostomia (HP:0000217)2.50756400
26Increased density of long bones (HP:0006392)2.48514987
27Broad metatarsal (HP:0001783)2.46966605
28Aplasia involving bones of the extremities (HP:0009825)2.45431423
29Aplasia involving bones of the upper limbs (HP:0009823)2.45431423
30Aplasia of the phalanges of the hand (HP:0009802)2.45431423
31Spontaneous hematomas (HP:0007420)2.44904920
32Optic neuritis (HP:0100653)2.44275758
33Retrobulbar optic neuritis (HP:0100654)2.44275758
34Vascular tortuosity (HP:0004948)2.40351955
35Abnormality of macrophages (HP:0004311)2.37575565
36Partial duplication of thumb phalanx (HP:0009944)2.37385804
37Arterial thrombosis (HP:0004420)2.36420149
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.34927560
39Osteolytic defects of the hand bones (HP:0009699)2.34927560
40Mediastinal lymphadenopathy (HP:0100721)2.33568262
41Systemic lupus erythematosus (HP:0002725)2.33287330
42Stomach cancer (HP:0012126)2.32229269
43Abnormality of the fingertips (HP:0001211)2.32022294
44Shallow orbits (HP:0000586)2.31405421
45Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.30253220
46Vertebral hypoplasia (HP:0008417)2.30253220
47Colitis (HP:0002583)2.29287365
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.27307656
49Partial duplication of the phalanx of hand (HP:0009999)2.25639362
50T lymphocytopenia (HP:0005403)2.24300503
51Broad face (HP:0000283)2.23882614
52Disproportionate tall stature (HP:0001519)2.23546278
53Premature loss of primary teeth (HP:0006323)2.22419634
54Recurrent gram-negative bacterial infections (HP:0005420)2.21934551
55Glomerulonephritis (HP:0000099)2.19749156
56Mitral stenosis (HP:0001718)2.19721163
57Peritonitis (HP:0002586)2.19317406
58Milia (HP:0001056)2.17614916
59Abnormality of the nasal mucosa (HP:0000433)2.14782657
60Short 4th metacarpal (HP:0010044)2.14484728
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14484728
62Abnormality of the nasal septum (HP:0000419)2.13470722
63Abnormality of complement system (HP:0005339)2.13030327
64Nasolacrimal duct obstruction (HP:0000579)2.11456021
65Camptodactyly of toe (HP:0001836)2.10368872
66Rectal prolapse (HP:0002035)2.09842332
67Premature rupture of membranes (HP:0001788)2.07992420
68Chronic otitis media (HP:0000389)2.02630246
69Meningitis (HP:0001287)2.02290551
70Recurrent bronchitis (HP:0002837)2.01908176
71Gastrointestinal infarctions (HP:0005244)2.01866822
72Abnormal vertebral ossification (HP:0100569)2.01211660
73Keratoconjunctivitis sicca (HP:0001097)2.00865833
74Atrophic scars (HP:0001075)1.99703921
75Pulmonary infiltrates (HP:0002113)1.99620011
76Coronal craniosynostosis (HP:0004440)1.99057331
77Segmental peripheral demyelination/remyelination (HP:0003481)1.96279376
78Pulmonary embolism (HP:0002204)1.95668390
79Nephritis (HP:0000123)1.95547372
80Cellulitis (HP:0100658)1.95497739
81Bicuspid aortic valve (HP:0001647)1.95436763
82Aneurysm (HP:0002617)1.94569421
83Inflammation of the large intestine (HP:0002037)1.92430189
84Obstructive sleep apnea (HP:0002870)1.92286722
85Nasal polyposis (HP:0100582)1.91831298
86Recurrent abscess formation (HP:0002722)1.91775816
87Recurrent bacterial skin infections (HP:0005406)1.90109604
88Dilatation of the ascending aorta (HP:0005111)1.89652780
89Pustule (HP:0200039)1.88324461
90Right ventricular cardiomyopathy (HP:0011663)1.87752994
91Emphysema (HP:0002097)1.87183430
92Pulmonary artery stenosis (HP:0004415)1.86036622
93Recurrent fungal infections (HP:0002841)1.83724301
94Chronic mucocutaneous candidiasis (HP:0002728)1.83446501
95Recurrent cutaneous fungal infections (HP:0011370)1.83446501
96Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82953260
97Thrombophlebitis (HP:0004418)1.82105364
98Alopecia of scalp (HP:0002293)1.81889545
99Abnormality of the peritoneum (HP:0002585)1.81584852
100Tracheomalacia (HP:0002779)1.81101839
101Abnormality of primary teeth (HP:0006481)1.80988144
102Abnormality of the 4th metacarpal (HP:0010012)1.80969203
103Agammaglobulinemia (HP:0004432)1.80860734
104Trigonocephaly (HP:0000243)1.79098676
105Autoimmune thrombocytopenia (HP:0001973)1.78736540
106Gastrointestinal inflammation (HP:0004386)1.78670259
107Aplasia cutis congenita (HP:0001057)1.78284928
108Keratoconjunctivitis (HP:0001096)1.77340654
109Stomatitis (HP:0010280)1.77151776
110Xanthomatosis (HP:0000991)1.77119324
111Cervical subluxation (HP:0003308)1.76952517
112Vasculitis (HP:0002633)1.76576786
113Neoplasm of the heart (HP:0100544)1.76569221
114Gastrointestinal stroma tumor (HP:0100723)1.74907161
115IgA deficiency (HP:0002720)1.74757838
116IgG deficiency (HP:0004315)1.73467690
117Abnormal delayed hypersensitivity skin test (HP:0002963)1.72229956
118Spondylolisthesis (HP:0003302)1.72012362
119Syringomyelia (HP:0003396)1.71809976
120Spinal cord lesions (HP:0100561)1.71809976
121Bone cyst (HP:0012062)1.70539670
122Interstitial pulmonary disease (HP:0006530)1.70513345
123Onycholysis (HP:0001806)1.70237382
124Split foot (HP:0001839)1.70154124
125Ankle contracture (HP:0006466)1.69244184
126Lip pit (HP:0100267)1.68955694
127Broad toe (HP:0001837)1.68412563
128IgM deficiency (HP:0002850)1.67158237
129Aortic valve stenosis (HP:0001650)1.66636991
130Gingivitis (HP:0000230)1.66465235
131Abnormality of the lacrimal duct (HP:0011481)1.66218202
132Increased IgE level (HP:0003212)1.65952928
133Gingival bleeding (HP:0000225)1.65006850
134Joint stiffness (HP:0001387)1.64850483
135Abnormality of the pleura (HP:0002103)1.64725416
136Hemoptysis (HP:0002105)1.64637544
137Abnormality of the incisor (HP:0000676)1.64569922
138Restrictive lung disease (HP:0002091)1.64244168
139Blue sclerae (HP:0000592)1.63321295
140Portal hypertension (HP:0001409)1.63192751
141Broad hallux (HP:0010055)1.62783925
142Abnormality of the common coagulation pathway (HP:0010990)1.61596822
143Joint contractures involving the joints of the feet (HP:0100492)1.61039987
144Flexion contracture of toe (HP:0005830)1.61039987
145Ureteral stenosis (HP:0000071)1.60727567
146Ectopia lentis (HP:0001083)1.60631040
147Abnormality of T cell number (HP:0011839)1.60270231
148Lymphangioma (HP:0100764)1.60114345
149Recurrent skin infections (HP:0001581)1.60066197
150Striae distensae (HP:0001065)1.60004299
151Wide anterior fontanel (HP:0000260)1.59264335
152Periodontitis (HP:0000704)1.59138969
153Abnormality of molar (HP:0011077)1.58774383
154Subacute progressive viral hepatitis (HP:0006572)1.55555388
155Cardiovascular calcification (HP:0011915)1.55162750
156Ulnar bowing (HP:0003031)1.54521330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.00611512
2MAPK152.95765012
3MAP3K142.63487909
4MAP4K12.49405011
5ERN12.43445307
6FGFR42.41951534
7TXK2.39864530
8SIK12.20402723
9EPHA32.16066955
10MAP3K102.13092797
11EPHB12.01805598
12TYK21.99951614
13TRIB31.96971939
14CHUK1.91130311
15STK101.85189100
16EPHA21.81801922
17CDK121.80825504
18JAK31.79724377
19IRAK31.76700700
20EPHB21.71697959
21JAK11.70675930
22NLK1.70050337
23LATS11.69680825
24FGFR31.68213079
25IKBKB1.64821263
26TBK11.63942684
27KDR1.62369779
28PTK61.61204282
29ITK1.58917926
30RPS6KA41.45791058
31IKBKE1.45239303
32IRAK41.43426048
33RIPK41.37215759
34LRRK21.34367289
35ZAP701.32077174
36NEK91.29152020
37MAP3K31.27545911
38CDC42BPA1.27323958
39PRPF4B1.23876182
40FES1.13989567
41CDK61.13422248
42MST41.13188718
43TGFBR11.11780024
44EEF2K1.08905613
45CSK1.08554887
46PKN21.08348831
47TAOK31.06457559
48MOS1.06250809
49DMPK1.05027721
50BTK1.01956729
51NUAK11.01631923
52PIM11.01485505
53TIE11.01222622
54MET1.00300052
55RIPK10.97580706
56PAK20.96497336
57STK30.95691407
58TEC0.95319950
59PDGFRA0.93976212
60MAP2K20.93428984
61PRKD20.91713834
62GSK3A0.87561776
63MARK20.86371615
64SIK30.86356872
65IRAK10.84677003
66MAP2K30.84123001
67MAP3K70.84037449
68GRK60.83295245
69TTN0.82192374
70BMX0.81354227
71JAK20.78921575
72PDGFRB0.74932758
73FGFR20.74634986
74DDR20.74514200
75CAMK1D0.72823749
76CDK90.71713585
77PAK40.70974393
78TESK20.70585854
79RPS6KC10.68945616
80RPS6KL10.68945616
81MATK0.68500414
82HCK0.68192605
83CSF1R0.66692839
84RPS6KA20.66065750
85PIM20.66044055
86LCK0.65418249
87MTOR0.64516475
88PRKAA20.63746724
89STK380.63495304
90MAP3K60.63288512
91RPS6KA60.63070820
92SIK20.62150402
93CAMK1G0.60857683
94DYRK1B0.60631763
95TSSK60.60424987
96BLK0.60302605
97LYN0.58863508
98MAPK70.58855153
99FGFR10.58633175
100KIT0.58233938
101PTK20.57469786
102MARK30.57260180
103SYK0.57149078
104SMG10.56424897
105FGR0.55963851
106MAP3K10.55565879
107STK240.54605066
108MELK0.54301070
109FER0.54253793
110HIPK20.52734358
111WNK10.51566688
112TESK10.51195006
113PRKD10.50483064
114TNK20.49442982
115MST1R0.49139419
116NTRK10.48848619
117INSR0.48732855
118ABL10.47858749
119TLK10.47672531
120CDK40.47341125
121ROCK10.46630484
122IGF1R0.46609002
123RPS6KA10.46428064
124TRPM70.45323659
125RPS6KB20.45210738
126ERBB20.43365987
127MAP3K130.43293094
128MAPK40.43166055
129FLT30.42638926
130BRD40.40435998
131* MAPKAPK20.39121802
132PRKCQ0.36075776
133CLK10.35887991
134MAPK120.35661209

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60191536
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.19004680
3Staphylococcus aureus infection_Homo sapiens_hsa051502.12429560
4Osteoclast differentiation_Homo sapiens_hsa043801.94429710
5Nitrogen metabolism_Homo sapiens_hsa009101.92673220
6Primary immunodeficiency_Homo sapiens_hsa053401.88054671
7Complement and coagulation cascades_Homo sapiens_hsa046101.84350606
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80862910
9Leishmaniasis_Homo sapiens_hsa051401.71331722
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.71061093
11Toxoplasmosis_Homo sapiens_hsa051451.63949785
12B cell receptor signaling pathway_Homo sapiens_hsa046621.59925923
13T cell receptor signaling pathway_Homo sapiens_hsa046601.56769764
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.55847098
15TNF signaling pathway_Homo sapiens_hsa046681.55570658
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54040535
17Small cell lung cancer_Homo sapiens_hsa052221.48746788
18Measles_Homo sapiens_hsa051621.47417409
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.47221351
20Notch signaling pathway_Homo sapiens_hsa043301.43270702
21Antigen processing and presentation_Homo sapiens_hsa046121.41675427
22Adherens junction_Homo sapiens_hsa045201.40553448
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36888608
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33379840
25Basal cell carcinoma_Homo sapiens_hsa052171.28259770
26Lysine degradation_Homo sapiens_hsa003101.26181307
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25188099
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23877993
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.22408241
30Chronic myeloid leukemia_Homo sapiens_hsa052201.22181292
31ECM-receptor interaction_Homo sapiens_hsa045121.21941747
32Hematopoietic cell lineage_Homo sapiens_hsa046401.21548773
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.20050057
34Caffeine metabolism_Homo sapiens_hsa002321.19059955
35Viral myocarditis_Homo sapiens_hsa054161.17980023
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16999388
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16518690
38Malaria_Homo sapiens_hsa051441.13764767
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09928922
40Proteoglycans in cancer_Homo sapiens_hsa052051.09192146
41Chemical carcinogenesis_Homo sapiens_hsa052041.08847301
42Type I diabetes mellitus_Homo sapiens_hsa049401.08128469
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07676052
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06207826
45HTLV-I infection_Homo sapiens_hsa051661.05538315
46PPAR signaling pathway_Homo sapiens_hsa033201.05127821
47Focal adhesion_Homo sapiens_hsa045101.05047960
48Rheumatoid arthritis_Homo sapiens_hsa053231.03129299
49TGF-beta signaling pathway_Homo sapiens_hsa043501.02966918
50Acute myeloid leukemia_Homo sapiens_hsa052211.02887351
51Herpes simplex infection_Homo sapiens_hsa051681.02658745
52Legionellosis_Homo sapiens_hsa051341.01948232
53Retinol metabolism_Homo sapiens_hsa008301.01678783
54Insulin resistance_Homo sapiens_hsa049311.00580573
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00228799
56Arginine biosynthesis_Homo sapiens_hsa002200.98858364
57Apoptosis_Homo sapiens_hsa042100.98785301
58Hepatitis B_Homo sapiens_hsa051610.98653888
59Graft-versus-host disease_Homo sapiens_hsa053320.95623837
60MicroRNAs in cancer_Homo sapiens_hsa052060.95460127
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.94693710
62Influenza A_Homo sapiens_hsa051640.94270708
63Tryptophan metabolism_Homo sapiens_hsa003800.93775148
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93004438
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92577713
66Asthma_Homo sapiens_hsa053100.91346347
67Fatty acid degradation_Homo sapiens_hsa000710.89458731
68Pancreatic cancer_Homo sapiens_hsa052120.89033256
69African trypanosomiasis_Homo sapiens_hsa051430.88019603
70Prostate cancer_Homo sapiens_hsa052150.87516004
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87331165
72Amoebiasis_Homo sapiens_hsa051460.87151041
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.86331705
74Allograft rejection_Homo sapiens_hsa053300.84938423
75Pertussis_Homo sapiens_hsa051330.83616719
76Hippo signaling pathway_Homo sapiens_hsa043900.81637388
77Pathways in cancer_Homo sapiens_hsa052000.77488879
78Prolactin signaling pathway_Homo sapiens_hsa049170.76437376
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.74927848
80Autoimmune thyroid disease_Homo sapiens_hsa053200.73644665
81Salmonella infection_Homo sapiens_hsa051320.71726780
82Other glycan degradation_Homo sapiens_hsa005110.71575105
83Hepatitis C_Homo sapiens_hsa051600.70369877
84MAPK signaling pathway_Homo sapiens_hsa040100.68968656
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.64719444
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64590758
87Endocytosis_Homo sapiens_hsa041440.63989003
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63269666
89Chemokine signaling pathway_Homo sapiens_hsa040620.63160206
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62626365
91Arachidonic acid metabolism_Homo sapiens_hsa005900.59583449
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58260566
93Rap1 signaling pathway_Homo sapiens_hsa040150.58087904
94Thyroid cancer_Homo sapiens_hsa052160.56759866
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56531054
96Bile secretion_Homo sapiens_hsa049760.56394618
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56212110
98Estrogen signaling pathway_Homo sapiens_hsa049150.56122536
99Platelet activation_Homo sapiens_hsa046110.56045813
100Colorectal cancer_Homo sapiens_hsa052100.55966272
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55420372
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.54733903
103Phagosome_Homo sapiens_hsa041450.54451783
104Prion diseases_Homo sapiens_hsa050200.54164521
105Phenylalanine metabolism_Homo sapiens_hsa003600.53718457
106Tuberculosis_Homo sapiens_hsa051520.53715474
107Dorso-ventral axis formation_Homo sapiens_hsa043200.53596914
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53280894
109FoxO signaling pathway_Homo sapiens_hsa040680.53077418
110Choline metabolism in cancer_Homo sapiens_hsa052310.53070113
111Non-small cell lung cancer_Homo sapiens_hsa052230.53022548
112Fat digestion and absorption_Homo sapiens_hsa049750.52666338
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52550886
114ErbB signaling pathway_Homo sapiens_hsa040120.52217566
115Endometrial cancer_Homo sapiens_hsa052130.52000957
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51883728
117Hedgehog signaling pathway_Homo sapiens_hsa043400.50107846
118Renal cell carcinoma_Homo sapiens_hsa052110.49727346
119Protein digestion and absorption_Homo sapiens_hsa049740.49699108
120Shigellosis_Homo sapiens_hsa051310.48135762
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47860651
122ABC transporters_Homo sapiens_hsa020100.47384509
123Circadian rhythm_Homo sapiens_hsa047100.46568401
124Histidine metabolism_Homo sapiens_hsa003400.46361914
125Viral carcinogenesis_Homo sapiens_hsa052030.45972223
126Bladder cancer_Homo sapiens_hsa052190.44390721
127Starch and sucrose metabolism_Homo sapiens_hsa005000.43023471
128beta-Alanine metabolism_Homo sapiens_hsa004100.42687848

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »