ZFP41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)4.61051793
2protein retention in ER lumen (GO:0006621)4.44203261
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.33731130
4pre-miRNA processing (GO:0031054)4.27195056
5adherens junction assembly (GO:0034333)4.18873961
6protein-DNA complex disassembly (GO:0032986)4.16859584
7nucleosome disassembly (GO:0006337)4.16859584
8focal adhesion assembly (GO:0048041)4.13148728
9cell-substrate adherens junction assembly (GO:0007045)4.13148728
10paraxial mesoderm development (GO:0048339)4.11678298
11DNA topological change (GO:0006265)4.10068768
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.09640577
13replication fork processing (GO:0031297)4.09126749
14DNA unwinding involved in DNA replication (GO:0006268)4.06319651
15dosage compensation (GO:0007549)3.98093027
16establishment of apical/basal cell polarity (GO:0035089)3.96409887
17semaphorin-plexin signaling pathway (GO:0071526)3.95693569
18negative regulation of cell size (GO:0045792)3.89541934
19negative regulation of RNA splicing (GO:0033119)3.89437462
20apoptotic process involved in morphogenesis (GO:0060561)3.88962014
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.84746256
22regulation of sister chromatid cohesion (GO:0007063)3.83373697
23regulation of NFAT protein import into nucleus (GO:0051532)3.83023936
24negative regulation of mRNA processing (GO:0050686)3.76459764
25peptidyl-arginine omega-N-methylation (GO:0035247)3.73931879
26establishment or maintenance of monopolar cell polarity (GO:0061339)3.67850956
27establishment of monopolar cell polarity (GO:0061162)3.67850956
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.61659750
29DNA strand renaturation (GO:0000733)3.61197808
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.60567034
31activation of Rac GTPase activity (GO:0032863)3.59501251
32regulation of RNA export from nucleus (GO:0046831)3.58744000
33spliceosomal tri-snRNP complex assembly (GO:0000244)3.57173032
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.55508225
35mannose metabolic process (GO:0006013)3.55277446
36DNA strand elongation involved in DNA replication (GO:0006271)3.55170078
37viral mRNA export from host cell nucleus (GO:0046784)3.53283161
38COPI coating of Golgi vesicle (GO:0048205)3.52173131
39Golgi transport vesicle coating (GO:0048200)3.52173131
40histone arginine methylation (GO:0034969)3.51477371
41cell-substrate junction assembly (GO:0007044)3.49111946
42protein localization to endosome (GO:0036010)3.48066588
43termination of RNA polymerase II transcription (GO:0006369)3.42735393
44DNA strand elongation (GO:0022616)3.40434071
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.38684255
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38684255
47sister chromatid segregation (GO:0000819)3.37951861
48cell-cell junction maintenance (GO:0045217)3.37511782
49endothelial cell chemotaxis (GO:0035767)3.35001037
50kinetochore organization (GO:0051383)3.34480472
51regulation of DNA damage checkpoint (GO:2000001)3.34091083
52base-excision repair (GO:0006284)3.33644132
53kinetochore assembly (GO:0051382)3.30677363
54telomere maintenance via semi-conservative replication (GO:0032201)3.30506053
55intracellular estrogen receptor signaling pathway (GO:0030520)3.30344822
56peptidyl-arginine N-methylation (GO:0035246)3.27020191
57peptidyl-arginine methylation (GO:0018216)3.27020191
58proline metabolic process (GO:0006560)3.25171519
59mitotic sister chromatid segregation (GO:0000070)3.23317270
60DNA ligation (GO:0006266)3.22757901
61regulation of glucose import in response to insulin stimulus (GO:2001273)3.22440168
62regulation of translational fidelity (GO:0006450)3.22284120
63regulation of ARF GTPase activity (GO:0032312)3.21992650
64regulation of early endosome to late endosome transport (GO:2000641)3.19744354
65transcription from mitochondrial promoter (GO:0006390)3.19728852
66embryonic process involved in female pregnancy (GO:0060136)3.16994982
67negative regulation of erythrocyte differentiation (GO:0045647)3.14884282
68maternal placenta development (GO:0001893)3.14590108
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.11787203
70negative regulation of cell cycle arrest (GO:0071157)3.11699912
71mRNA cleavage (GO:0006379)3.10858606
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09657550
73DNA double-strand break processing (GO:0000729)3.08924971
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.08136455
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08136455
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08136455
77convergent extension (GO:0060026)3.08044479
78resolution of meiotic recombination intermediates (GO:0000712)3.06035875
79negative regulation of mRNA metabolic process (GO:1903312)3.04430179
80lateral sprouting from an epithelium (GO:0060601)3.04094694
81basement membrane organization (GO:0071711)3.04008493
82heart field specification (GO:0003128)3.03723054
83secondary heart field specification (GO:0003139)3.03723054
84embryonic camera-type eye development (GO:0031076)3.02584601
85oxidative demethylation (GO:0070989)3.02342319
86negative regulation of chromosome segregation (GO:0051985)3.00686663
87DNA replication-dependent nucleosome assembly (GO:0006335)2.96419970
88DNA replication-dependent nucleosome organization (GO:0034723)2.96419970
89regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.95515525
90DNA deamination (GO:0045006)2.92482709
91barbed-end actin filament capping (GO:0051016)2.92325903
92peptidyl-lysine dimethylation (GO:0018027)2.90151985
93negative regulation of fatty acid transport (GO:2000192)2.87429584
94meiotic chromosome segregation (GO:0045132)2.87115723
95mitochondrial DNA metabolic process (GO:0032042)2.85376420
96formation of translation preinitiation complex (GO:0001731)2.83747960
97glucocorticoid receptor signaling pathway (GO:0042921)2.82888814
98mitotic G1 DNA damage checkpoint (GO:0031571)2.82143805
99regulation of histone H3-K9 methylation (GO:0051570)2.81097765
100regulation of posttranscriptional gene silencing (GO:0060147)2.81008381
101regulation of gene silencing by miRNA (GO:0060964)2.81008381
102regulation of gene silencing by RNA (GO:0060966)2.81008381
103negative regulation of histone methylation (GO:0031061)2.80247496
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.79494135
105mitotic recombination (GO:0006312)2.78772604
106protein localization to kinetochore (GO:0034501)2.78716157
107microtubule depolymerization (GO:0007019)2.78378939
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.77507660
109regulation of double-strand break repair (GO:2000779)2.77261029
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76900376
111positive regulation of chromosome segregation (GO:0051984)2.76738080
112atrioventricular valve morphogenesis (GO:0003181)2.76436308
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76113243
114telomere maintenance via recombination (GO:0000722)2.75454194
115regulation of cholesterol biosynthetic process (GO:0045540)2.75401301
116negative regulation of JAK-STAT cascade (GO:0046426)2.74794636
117positive regulation of histone deacetylation (GO:0031065)2.74669676
118epithelial cell-cell adhesion (GO:0090136)2.73689009
119poly(A)+ mRNA export from nucleus (GO:0016973)2.73268561
120non-recombinational repair (GO:0000726)2.73252072
121double-strand break repair via nonhomologous end joining (GO:0006303)2.73252072
122stress fiber assembly (GO:0043149)2.72180231
123positive regulation by host of viral transcription (GO:0043923)2.71510541
124regulation of hippo signaling (GO:0035330)2.71232497
125mRNA splice site selection (GO:0006376)2.70803685
126DNA duplex unwinding (GO:0032508)2.70577663
127regulation of extracellular matrix disassembly (GO:0010715)2.70376840
128mitotic nuclear envelope disassembly (GO:0007077)2.69775094
129hemidesmosome assembly (GO:0031581)2.69764741
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69663437
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69587574
132DNA geometric change (GO:0032392)2.69017659
133mRNA splicing, via spliceosome (GO:0000398)2.68945766
134RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.68945766
135mRNA export from nucleus (GO:0006406)2.68153076
136base-excision repair, AP site formation (GO:0006285)2.66933634
137vascular endothelial growth factor signaling pathway (GO:0038084)2.66912666
138cell volume homeostasis (GO:0006884)2.66881274
139regulation of chromosome segregation (GO:0051983)2.66814019
140mRNA transport (GO:0051028)2.66713077
141regulation of monocyte differentiation (GO:0045655)2.66484465
142positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66358124
143spinal cord development (GO:0021510)2.66172178
144branching involved in mammary gland duct morphogenesis (GO:0060444)2.65860208
1453-UTR-mediated mRNA stabilization (GO:0070935)2.64862882
146neural tube development (GO:0021915)2.64718693
147DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64650423
148nodal signaling pathway (GO:0038092)2.64476689
149RNA splicing, via transesterification reactions (GO:0000375)2.64473808
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.64443128
151apoptotic process involved in development (GO:1902742)2.63108808
152embryonic eye morphogenesis (GO:0048048)2.61494463
153cochlea morphogenesis (GO:0090103)2.60272678
154snRNA metabolic process (GO:0016073)2.59891143
155regulation of ARF protein signal transduction (GO:0032012)2.59300633
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.58633519
157modulation by virus of host morphology or physiology (GO:0019048)2.57062969
158locomotory exploration behavior (GO:0035641)2.56467695
159protein targeting to plasma membrane (GO:0072661)2.56209278
160histone H4 deacetylation (GO:0070933)2.54974801
161negative regulation of viral release from host cell (GO:1902187)2.53976806
162heterochromatin organization (GO:0070828)2.52134369
163regulation of chromatin binding (GO:0035561)2.51783575
164positive regulation of nuclease activity (GO:0032075)2.51184029
165retrograde transport, endosome to Golgi (GO:0042147)2.50395032
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49859781
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49366557
168positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49224770
169cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.47769859
170positive regulation of CREB transcription factor activity (GO:0032793)2.40881223
171receptor recycling (GO:0001881)2.40877700
172regulation of endothelial cell chemotaxis (GO:2001026)2.39880995
173eye morphogenesis (GO:0048592)2.39194904
174regulation of fatty acid beta-oxidation (GO:0031998)2.38773030
175osteoblast development (GO:0002076)2.36186198
176negative regulation of autophagy (GO:0010507)2.36049839
177glucose 6-phosphate metabolic process (GO:0051156)2.34574393
178Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34525986
179positive regulation of synapse maturation (GO:0090129)2.32341731
180cell junction maintenance (GO:0034331)2.31879797
181embryonic camera-type eye morphogenesis (GO:0048596)2.31779765
182epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31761125
183receptor catabolic process (GO:0032801)2.30536352
184corticosteroid receptor signaling pathway (GO:0031958)2.29673715
185desmosome organization (GO:0002934)2.29397361
186modulation by virus of host process (GO:0019054)2.29143574
187modulation by symbiont of host cellular process (GO:0044068)2.28942936
188placenta blood vessel development (GO:0060674)2.27680594
189cortical actin cytoskeleton organization (GO:0030866)2.27368568
190endoplasmic reticulum unfolded protein response (GO:0030968)2.25927266
191glucose catabolic process (GO:0006007)2.25772392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91221906
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87964033
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.61093698
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.27159430
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11397757
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.04844846
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94143369
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.72258195
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.69955935
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62824681
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60747357
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59718611
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.52473676
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49573321
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45872355
16RACK7_27058665_Chip-Seq_MCF-7_Human2.43276935
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31362874
18SOX2_18555785_ChIP-Seq_MESCs_Mouse2.31182689
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22406043
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.20277086
21KDM2B_26808549_Chip-Seq_K562_Human2.19480836
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15242456
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.12548412
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.07782018
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.07181410
26ZNF263_19887448_ChIP-Seq_K562_Human2.06230533
27TCF7_22412390_ChIP-Seq_EML_Mouse2.04690315
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03556789
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.03364892
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99809776
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97869227
32NANOG_21062744_ChIP-ChIP_HESCs_Human1.95466141
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93043015
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90933280
35MYC_22102868_ChIP-Seq_BL_Human1.90239340
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85197851
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83612611
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83561315
39P68_20966046_ChIP-Seq_HELA_Human1.82215476
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81423577
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81423577
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81423577
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81404882
44XRN2_22483619_ChIP-Seq_HELA_Human1.78340550
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72645203
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72584532
47SMC4_20622854_ChIP-Seq_HELA_Human1.72450725
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72279578
49* VDR_21846776_ChIP-Seq_THP-1_Human1.69503843
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68630095
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68478216
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67021441
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66861355
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66499308
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.66368768
56* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65534419
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64975931
58* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63551236
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.62545021
60CREB1_26743006_Chip-Seq_LNCaP_Human1.62033393
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.61615023
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.60462549
63* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60246027
64* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60193945
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59203349
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58045138
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57194456
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.54731656
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53275885
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53166440
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52499567
72* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50974213
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50051577
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48452076
75TP53_22127205_ChIP-Seq_IMR90_Human1.48440459
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48390622
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47943660
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46977527
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46892370
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45859221
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45355651
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44698558
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42819794
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42037265
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40737266
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40549398
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.40430531
88TTF2_22483619_ChIP-Seq_HELA_Human1.39711992
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39541556
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38885437
91VDR_24763502_ChIP-Seq_THP-1_Human1.35816583
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34231254
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33432317
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32922913
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32383607
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31516673
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30971248
98CTCF_27219007_Chip-Seq_Bcells_Human1.30370780
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29599138
100* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29595590
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29571325
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29513911
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29472810
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29027629
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28860032
106ATF3_27146783_Chip-Seq_COLON_Human1.26460918
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25644647
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25635328
109CLOCK_20551151_ChIP-Seq_293T_Human1.25423209
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24894936
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24270207
112AR_21909140_ChIP-Seq_LNCAP_Human1.23652443
113* GABP_19822575_ChIP-Seq_HepG2_Human1.23378245
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.21979991
115MAF_26560356_Chip-Seq_TH2_Human1.21604195
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.21203996
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20361972
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19128885
119TET1_21490601_ChIP-Seq_MESCs_Mouse1.18957909
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18291830
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17672430
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17664279
123* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17443637
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16019779
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15889073
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13153018
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12747739
128* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12175286
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12160294
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10903969
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10864027
132KDM2B_26808549_Chip-Seq_DND41_Human1.10797034
133ERG_21242973_ChIP-ChIP_JURKAT_Human1.10753779
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.09585680
135* TP63_22573176_ChIP-Seq_HFKS_Human1.09055321
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07196895
137NCOR1_26117541_ChIP-Seq_K562_Human1.07000779
138CIITA_25753668_ChIP-Seq_RAJI_Human1.06925929
139POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06881381
140PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06642944
141ETS1_20019798_ChIP-Seq_JURKAT_Human1.06580063
142UBF1/2_26484160_Chip-Seq_HMECs_Human1.06382569
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05953245
144ESR1_20079471_ChIP-ChIP_T-47D_Human1.05309294
145BCOR_27268052_Chip-Seq_Bcells_Human1.04860928
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.04638513
147ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04633229
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03962573
149* RARA_24833708_ChIP-Seq_LIVER_Mouse1.03799835
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03549355
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03202267
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03081826
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02727880
154GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02652889
155JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99771398
156KDM5A_27292631_Chip-Seq_BREAST_Human0.99015242
157EGR1_19374776_ChIP-ChIP_THP-1_Human0.98855109
158UTX_26944678_Chip-Seq_JUKART_Human0.98230774
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.97827189
160MAF_26560356_Chip-Seq_TH1_Human0.97524127
161DROSHA_22980978_ChIP-Seq_HELA_Human0.97083486
162TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95974008
163TP53_23651856_ChIP-Seq_MEFs_Mouse0.95127176
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94805357
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94703691
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.94426893
167RARB_27405468_Chip-Seq_BRAIN_Mouse0.93757002
168CTCF_21964334_Chip-Seq_Bcells_Human0.92901546
169* LXR_22292898_ChIP-Seq_THP-1_Human0.92026613
170WDR5_24793694_ChIP-Seq_LNCAP_Human0.91929063
171TET1_21451524_ChIP-Seq_MESCs_Mouse0.91158679
172* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90738108
173RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89525748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.31478257
2MP0010030_abnormal_orbit_morphology4.29453513
3MP0008057_abnormal_DNA_replication3.85713214
4MP0002653_abnormal_ependyma_morphology3.06924951
5MP0001849_ear_inflammation2.94025499
6MP0005058_abnormal_lysosome_morphology2.92906919
7MP0010094_abnormal_chromosome_stability2.90936282
8MP0003890_abnormal_embryonic-extraembry2.89752201
9MP0004858_abnormal_nervous_system2.67859041
10MP0005451_abnormal_body_composition2.62875070
11MP0003111_abnormal_nucleus_morphology2.40721377
12MP0003119_abnormal_digestive_system2.38144696
13MP0005409_darkened_coat_color2.35368011
14MP0003566_abnormal_cell_adhesion2.29422950
15MP0000537_abnormal_urethra_morphology2.27254272
16MP0009278_abnormal_bone_marrow2.17802120
17MP0002249_abnormal_larynx_morphology2.15393508
18MP0000566_synostosis2.14825422
19MP0004233_abnormal_muscle_weight2.14705496
20MP0003077_abnormal_cell_cycle2.12292955
21MP0009053_abnormal_anal_canal2.12007834
22MP0000678_abnormal_parathyroid_gland2.09946949
23MP0003329_amyloid_beta_deposits2.09912615
24MP0008932_abnormal_embryonic_tissue2.06284655
25MP0002282_abnormal_trachea_morphology2.03699119
26MP0001293_anophthalmia2.00017832
27MP0005257_abnormal_intraocular_pressure1.95238046
28MP0003172_abnormal_lysosome_physiology1.93070650
29MP0005076_abnormal_cell_differentiation1.92511650
30MP0002084_abnormal_developmental_patter1.91765744
31MP0008260_abnormal_autophagy1.91474824
32MP0004133_heterotaxia1.89768385
33MP0002877_abnormal_melanocyte_morpholog1.88955293
34MP0004957_abnormal_blastocyst_morpholog1.87501523
35MP0000751_myopathy1.84360032
36MP0008438_abnormal_cutaneous_collagen1.84186444
37MP0003091_abnormal_cell_migration1.83157095
38MP0003283_abnormal_digestive_organ1.83059048
39MP0002085_abnormal_embryonic_tissue1.82492480
40MP0008877_abnormal_DNA_methylation1.81343414
41MP0004272_abnormal_basement_membrane1.78282598
42MP0002089_abnormal_postnatal_growth/wei1.77550330
43MP0003453_abnormal_keratinocyte_physiol1.75728738
44MP0003693_abnormal_embryo_hatching1.74443462
45MP0008058_abnormal_DNA_repair1.72455707
46MP0009840_abnormal_foam_cell1.67201261
47MP0001697_abnormal_embryo_size1.67049188
48MP0000049_abnormal_middle_ear1.66910890
49MP0008789_abnormal_olfactory_epithelium1.66799189
50MP0000778_abnormal_nervous_system1.66538160
51MP0001348_abnormal_lacrimal_gland1.66102859
52MP0003385_abnormal_body_wall1.63697985
53MP0000733_abnormal_muscle_development1.62393426
54MP0005171_absent_coat_pigmentation1.61876803
55MP0004185_abnormal_adipocyte_glucose1.61362398
56MP0004197_abnormal_fetal_growth/weight/1.60031971
57MP0002009_preneoplasia1.59674865
58MP0005623_abnormal_meninges_morphology1.57217867
59MP0002932_abnormal_joint_morphology1.57107553
60MP0004859_abnormal_synaptic_plasticity1.56358401
61MP0003861_abnormal_nervous_system1.55541126
62MP0001730_embryonic_growth_arrest1.53661140
63MP0003121_genomic_imprinting1.52717289
64MP0000350_abnormal_cell_proliferation1.50416216
65MP0001672_abnormal_embryogenesis/_devel1.49749042
66MP0005380_embryogenesis_phenotype1.49749042
67MP0006072_abnormal_retinal_apoptosis1.48179390
68MP0003123_paternal_imprinting1.48051701
69MP0000003_abnormal_adipose_tissue1.47874165
70MP0003755_abnormal_palate_morphology1.47798163
71MP0003935_abnormal_craniofacial_develop1.45989131
72MP0003567_abnormal_fetal_cardiomyocyte1.44802896
73MP0001346_abnormal_lacrimal_gland1.42524264
74MP0002938_white_spotting1.40809764
75MP0008007_abnormal_cellular_replicative1.39156077
76MP0003115_abnormal_respiratory_system1.38633804
77MP0003942_abnormal_urinary_system1.36424616
78MP0008995_early_reproductive_senescence1.36059504
79MP0002086_abnormal_extraembryonic_tissu1.35087385
80MP0003937_abnormal_limbs/digits/tail_de1.34018033
81MP0002116_abnormal_craniofacial_bone1.33422084
82MP0002796_impaired_skin_barrier1.32817203
83MP0003938_abnormal_ear_development1.28577059
84MP0000681_abnormal_thyroid_gland1.26145724
85MP0003984_embryonic_growth_retardation1.25638531
86MP0002111_abnormal_tail_morphology1.25054578
87MP0002088_abnormal_embryonic_growth/wei1.23172799
88MP0005394_taste/olfaction_phenotype1.22566419
89MP0005499_abnormal_olfactory_system1.22566419
90MP0005501_abnormal_skin_physiology1.21117434
91MP0003279_aneurysm1.20885097
92MP0002697_abnormal_eye_size1.20165675
93MP0002751_abnormal_autonomic_nervous1.18793639
94MP0003315_abnormal_perineum_morphology1.18393367
95MP0003122_maternal_imprinting1.18047616
96MP0005666_abnormal_adipose_tissue1.17930773
97MP0002092_abnormal_eye_morphology1.17216867
98MP0005248_abnormal_Harderian_gland1.16803269
99MP0005621_abnormal_cell_physiology1.16553488
100MP0004381_abnormal_hair_follicle1.15479720
101MP0002080_prenatal_lethality1.15371664
102MP0005375_adipose_tissue_phenotype1.14965400
103MP0002060_abnormal_skin_morphology1.13984288
104MP0010352_gastrointestinal_tract_polyps1.13802250
105MP0001286_abnormal_eye_development1.12637250
106MP0003191_abnormal_cellular_cholesterol1.12293765
107MP0004808_abnormal_hematopoietic_stem1.11417527
108MP0002210_abnormal_sex_determination1.11236238
109MP0010234_abnormal_vibrissa_follicle1.10315570
110MP0005397_hematopoietic_system_phenotyp1.09526472
111MP0001545_abnormal_hematopoietic_system1.09526472
112MP0000428_abnormal_craniofacial_morphol1.09197167
113MP0002114_abnormal_axial_skeleton1.08900003
114MP0001929_abnormal_gametogenesis1.07462431
115MP0001145_abnormal_male_reproductive1.06725289
116MP0000759_abnormal_skeletal_muscle1.06669052
117MP0005023_abnormal_wound_healing1.06571894
118MP0000432_abnormal_head_morphology1.06057590
119MP0000747_muscle_weakness1.05734627
120MP0004264_abnormal_extraembryonic_tissu1.05389043
121MP0001958_emphysema1.04472383
122MP0004782_abnormal_surfactant_physiolog1.01554823
123MP0006292_abnormal_olfactory_placode1.01021016
124MP0010630_abnormal_cardiac_muscle1.00949774
125MP0003698_abnormal_male_reproductive1.00825414
126MP0009672_abnormal_birth_weight1.00025317
127MP0000462_abnormal_digestive_system0.99492673
128MP0005410_abnormal_fertilization0.98929442
129MP0005174_abnormal_tail_pigmentation0.97391841
130MP0003634_abnormal_glial_cell0.97321041
131MP0002102_abnormal_ear_morphology0.96907470
132MP0002396_abnormal_hematopoietic_system0.96827173
133MP0002233_abnormal_nose_morphology0.96396313
134MP0004947_skin_inflammation0.94232371
135MP0003300_gastrointestinal_ulcer0.94153319
136MP0005391_vision/eye_phenotype0.93880081
137MP0000569_abnormal_digit_pigmentation0.93829579
138MP0005508_abnormal_skeleton_morphology0.93825568
139MP0003786_premature_aging0.93207691
140MP0000767_abnormal_smooth_muscle0.92097663
141MP0009384_cardiac_valve_regurgitation0.91715000
142MP0002081_perinatal_lethality0.91691992
143MP0001340_abnormal_eyelid_morphology0.90450052
144MP0000631_abnormal_neuroendocrine_gland0.89790595
145MP0003879_abnormal_hair_cell0.89091222
146MP0002152_abnormal_brain_morphology0.88992538
147MP0009250_abnormal_appendicular_skeleto0.87333576
148MP0001915_intracranial_hemorrhage0.87079811
149MP0005187_abnormal_penis_morphology0.86756391
150MP0005670_abnormal_white_adipose0.86335335
151MP0005503_abnormal_tendon_morphology0.86324099
152MP0000490_abnormal_crypts_of0.86091198
153MP0004087_abnormal_muscle_fiber0.85444497
154MP0004134_abnormal_chest_morphology0.84762049
155MP0000858_altered_metastatic_potential0.84397962
156MP0000653_abnormal_sex_gland0.84297062
157MP0002098_abnormal_vibrissa_morphology0.84214393
158MP0000467_abnormal_esophagus_morphology0.81410680
159MP0002925_abnormal_cardiovascular_devel0.81266057
160MP0000955_abnormal_spinal_cord0.81082447
161MP0000534_abnormal_ureter_morphology0.79896957
162MP0002896_abnormal_bone_mineralization0.78224131
163MP0000762_abnormal_tongue_morphology0.77951079
164MP0001299_abnormal_eye_distance/0.77915368
165MP0002161_abnormal_fertility/fecundity0.77888570
166MP0002234_abnormal_pharynx_morphology0.77485960
167MP0002970_abnormal_white_adipose0.77443921
168MP0001502_abnormal_circadian_rhythm0.74939605
169MP0001216_abnormal_epidermal_layer0.73117107
170MP0002108_abnormal_muscle_morphology0.72580537
171MP0001270_distended_abdomen0.71229280

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.00077281
2Facial hemangioma (HP:0000329)3.98281274
3Obstructive sleep apnea (HP:0002870)3.54488689
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.51920356
5Short 4th metacarpal (HP:0010044)3.51920356
6Broad face (HP:0000283)3.42877626
7Coronal craniosynostosis (HP:0004440)3.29469757
8Renal duplication (HP:0000075)3.23599412
9Broad alveolar ridges (HP:0000187)3.12408195
10Protrusio acetabuli (HP:0003179)3.10985379
11Patellar aplasia (HP:0006443)3.07262954
12Intestinal atresia (HP:0011100)2.93079939
13Concave nail (HP:0001598)2.88511894
14Aplasia/Hypoplasia of the patella (HP:0006498)2.86511521
15Shallow orbits (HP:0000586)2.85626775
16Abnormal number of incisors (HP:0011064)2.84301916
17Cerebral aneurysm (HP:0004944)2.82269329
18Annular pancreas (HP:0001734)2.77239781
19Abnormality of the 4th metacarpal (HP:0010012)2.74363276
20Distal upper limb amyotrophy (HP:0007149)2.73744542
21Upper limb amyotrophy (HP:0009129)2.73744542
22Rectovaginal fistula (HP:0000143)2.73678183
23Rectal fistula (HP:0100590)2.73678183
24Hyperacusis (HP:0010780)2.68904683
25Premature rupture of membranes (HP:0001788)2.68710799
26Increased nuchal translucency (HP:0010880)2.67447531
27Alacrima (HP:0000522)2.65284515
28Volvulus (HP:0002580)2.62760315
29Selective tooth agenesis (HP:0001592)2.58685339
30Abnormality of the labia minora (HP:0012880)2.58682177
31Abnormality of the astrocytes (HP:0100707)2.56989607
32Astrocytoma (HP:0009592)2.56989607
33Absent radius (HP:0003974)2.55010592
34Intestinal fistula (HP:0100819)2.50684507
35Heterotopia (HP:0002282)2.50421587
36Disproportionate tall stature (HP:0001519)2.49963265
37Short nail (HP:0001799)2.48776713
38Cervical subluxation (HP:0003308)2.47971125
39Distal lower limb amyotrophy (HP:0008944)2.47320850
40Absent forearm bone (HP:0003953)2.47101860
41Aplasia involving forearm bones (HP:0009822)2.47101860
42Bronchomalacia (HP:0002780)2.46446722
43Abnormality of the aortic arch (HP:0012303)2.44509801
44Anteriorly placed anus (HP:0001545)2.42087085
45Flat acetabular roof (HP:0003180)2.41472114
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.35504563
47Achilles tendon contracture (HP:0001771)2.34983695
48Medulloblastoma (HP:0002885)2.33920282
49Thin bony cortex (HP:0002753)2.33693730
50Renovascular hypertension (HP:0100817)2.33392703
51Stridor (HP:0010307)2.33359123
52Short humerus (HP:0005792)2.33289986
53Turricephaly (HP:0000262)2.32334053
54Aplasia/hypoplasia of the humerus (HP:0006507)2.31786608
55Spina bifida occulta (HP:0003298)2.31638772
56Overriding aorta (HP:0002623)2.30875590
57Anophthalmia (HP:0000528)2.30504986
58Increased number of teeth (HP:0011069)2.30020389
59Capillary hemangiomas (HP:0005306)2.29691840
60Decreased lacrimation (HP:0000633)2.23915068
61High anterior hairline (HP:0009890)2.23750485
62Vaginal fistula (HP:0004320)2.23605854
63Increased variability in muscle fiber diameter (HP:0003557)2.23148222
64Spinal rigidity (HP:0003306)2.23134577
65Increased connective tissue (HP:0009025)2.22569836
66Gastrointestinal atresia (HP:0002589)2.22164189
67Elfin facies (HP:0004428)2.21494676
68Hemorrhage of the eye (HP:0011885)2.20788393
69Ulnar bowing (HP:0003031)2.20774534
70Abnormality of the thoracic spine (HP:0100711)2.19286180
71Orthostatic hypotension (HP:0001278)2.18881814
72Aqueductal stenosis (HP:0002410)2.18837725
73Bowing of the arm (HP:0006488)2.18174809
74Bowed forearm bones (HP:0003956)2.18174809
75Abnormality of the diencephalon (HP:0010662)2.18118877
76Patellar dislocation (HP:0002999)2.17475321
77Ependymoma (HP:0002888)2.15842966
78Nephroblastoma (Wilms tumor) (HP:0002667)2.15516273
79Pointed chin (HP:0000307)2.15496858
80Trigonocephaly (HP:0000243)2.13636893
81Vertebral compression fractures (HP:0002953)2.10877664
82Abnormality of the intervertebral disk (HP:0005108)2.10056628
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.09732073
84Tented upper lip vermilion (HP:0010804)2.08307643
85Advanced eruption of teeth (HP:0006288)2.08218846
86Syringomyelia (HP:0003396)2.07195567
87Spinal cord lesions (HP:0100561)2.07195567
88Colon cancer (HP:0003003)2.06424011
89Abnormality of the Achilles tendon (HP:0005109)2.05863484
90Long palpebral fissure (HP:0000637)2.05410835
91Urethral obstruction (HP:0000796)2.04427046
92Flattened epiphyses (HP:0003071)2.04001212
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03674287
94Hand muscle atrophy (HP:0009130)2.03501557
95Hamartoma (HP:0010566)2.03072856
96Fragile skin (HP:0001030)2.02897850
97Broad distal phalanx of finger (HP:0009836)2.01760761
98Dysmetric saccades (HP:0000641)2.01651083
99Abnormality of abdominal situs (HP:0011620)2.01340760
100Abdominal situs inversus (HP:0003363)2.01340760
101Metaphyseal cupping (HP:0003021)2.01260140
102Embryonal renal neoplasm (HP:0011794)2.01193323
103Neoplasm of the oral cavity (HP:0100649)2.00509333
104Absent thumb (HP:0009777)1.99699937
105Glioma (HP:0009733)1.99307840
106Abnormality of the ileum (HP:0001549)1.99012073
107Cerebral inclusion bodies (HP:0100314)1.98295878
108Megalocornea (HP:0000485)1.98224424
109Bladder diverticulum (HP:0000015)1.96675906
110Thoracic kyphosis (HP:0002942)1.96667077
111Asymmetry of the thorax (HP:0001555)1.96531464
112Narrow nasal bridge (HP:0000446)1.95956857
113Short 5th finger (HP:0009237)1.95875206
114Thin ribs (HP:0000883)1.94434172
115Bowel incontinence (HP:0002607)1.94397187
116Mildly elevated creatine phosphokinase (HP:0008180)1.94193608
117Hemivertebrae (HP:0002937)1.93470925
118Insomnia (HP:0100785)1.93315084
119Broad thumb (HP:0011304)1.93061364
120Aneurysm (HP:0002617)1.92863021
121Supernumerary spleens (HP:0009799)1.92604311
122Esophageal atresia (HP:0002032)1.92404403
123Mitral regurgitation (HP:0001653)1.91921269
124Arnold-Chiari malformation (HP:0002308)1.91447681
125Arterial tortuosity (HP:0005116)1.90836752
126Atelectasis (HP:0100750)1.89429182
127Biconcave vertebral bodies (HP:0004586)1.89353668
128Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88218091
129Natal tooth (HP:0000695)1.87596129
130Midline defect of the nose (HP:0004122)1.86869575
131Supranuclear gaze palsy (HP:0000605)1.86636292
132Poikiloderma (HP:0001029)1.86245068
133Difficulty climbing stairs (HP:0003551)1.86050264
134Deep venous thrombosis (HP:0002625)1.85980029
135Abnormality of the lower motor neuron (HP:0002366)1.85633810
136Congenital hip dislocation (HP:0001374)1.85082814
137Broad metatarsal (HP:0001783)1.83626121
138Lower limb amyotrophy (HP:0007210)1.82975470
139Abnormality of the fingertips (HP:0001211)1.82373773
140Broad toe (HP:0001837)1.82371265
141Proximal placement of thumb (HP:0009623)1.81426199
142Premature skin wrinkling (HP:0100678)1.80961028
143Vertebral fusion (HP:0002948)1.80736931
144Precocious puberty (HP:0000826)1.80318551
145Atrophic scars (HP:0001075)1.80200987
146Genu recurvatum (HP:0002816)1.79633997
147Long eyelashes (HP:0000527)1.79039042
148Abnormality of skeletal muscle fiber size (HP:0012084)1.78718030
149Abnormal respiratory epithelium morphology (HP:0012253)1.78565738
150Abnormal respiratory motile cilium morphology (HP:0005938)1.78565738
151Cortical dysplasia (HP:0002539)1.78346726
152Short thumb (HP:0009778)1.78330056
153Blue sclerae (HP:0000592)1.78025531
154Germ cell neoplasia (HP:0100728)1.77607953
155Premature graying of hair (HP:0002216)1.76290527
156Abnormal large intestine physiology (HP:0012700)1.75636971
157Flat cornea (HP:0007720)1.75494190
158Skull defect (HP:0001362)1.74558465
159Abnormality of dentin (HP:0010299)1.73780167
160Back pain (HP:0003418)1.73666796
161Abnormality of the antihelix (HP:0009738)1.73429979
162Distal lower limb muscle weakness (HP:0009053)1.73041366
163Choanal stenosis (HP:0000452)1.72929700
164Hypochromic microcytic anemia (HP:0004840)1.72152284
165Hypotelorism (HP:0000601)1.72071471
166Abnormality of chromosome segregation (HP:0002916)1.71777035
167Ectopic kidney (HP:0000086)1.71621874
168Aplasia/Hypoplasia of the sternum (HP:0006714)1.70166402
169Atresia of the external auditory canal (HP:0000413)1.69979296
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69630810
171Hypoplasia of the radius (HP:0002984)1.69459474
172Generalized amyotrophy (HP:0003700)1.69431021
173Vascular tortuosity (HP:0004948)1.69113543
174Dislocated radial head (HP:0003083)1.68423315
175Self-mutilation (HP:0000742)1.68418271
176Joint laxity (HP:0001388)1.67855607
177Elbow flexion contracture (HP:0002987)1.67805256
178Male infertility (HP:0003251)1.67618687
179Vertebral arch anomaly (HP:0008438)1.67512982
180Ankle contracture (HP:0006466)1.67348521
181Preaxial foot polydactyly (HP:0001841)1.67298805
182Broad phalanges of the hand (HP:0009768)1.67104352
183Bell-shaped thorax (HP:0001591)1.65239672
184Long toe (HP:0010511)1.63571420
185Abnormality of the columella (HP:0009929)1.63503819
186Abnormal ossification of hand bones (HP:0005921)1.62620850
187Colitis (HP:0002583)1.62084498
188Neurofibrillary tangles (HP:0002185)1.60888657
189Hypercortisolism (HP:0001578)1.60736683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.00072369
2SIK13.73067087
3SMG13.11768863
4DDR22.98640285
5TYRO32.85010821
6CDC72.80165253
7ERN12.59600653
8MAP3K102.53110885
9PRPF4B2.50162522
10EPHA22.50121923
11UHMK12.41376586
12PKN22.30950778
13MAP3K62.30651764
14BUB12.12454059
15IRAK32.08671622
16RIPK12.07250885
17NEK22.01105965
18MAPK151.93686238
19DYRK31.89989146
20DYRK1B1.84671404
21PDGFRA1.83306528
22CDK71.81729899
23YES11.81044811
24FGFR41.80872553
25LATS21.80723145
26CHEK21.76441092
27MARK11.73352054
28CDK121.72246259
29TTN1.71792930
30EPHB21.70751518
31MST1R1.67906915
32SRPK11.56819449
33FGR1.55758284
34DYRK21.54788698
35PRKD31.49632101
36ERBB31.49328302
37ATR1.47575547
38MKNK11.45510122
39WEE11.43114356
40MATK1.41686051
41MARK21.36937478
42TLK11.36759461
43PLK11.34114050
44MAP3K111.30957392
45NME21.30420566
46TGFBR11.26985600
47PTK21.25221984
48LMTK21.24774607
49CDK61.22910340
50MET1.19625769
51EPHB11.15612456
52PASK1.15537237
53PINK11.13775681
54DAPK11.13640130
55LATS11.12976140
56KSR11.10758153
57ACVR1B1.10633427
58NTRK11.09440663
59PRKD21.07771993
60EEF2K1.06836737
61CHEK11.05488362
62BMX1.03159449
63MTOR1.02049374
64CAMK1D1.01382740
65MAP3K130.99720429
66NTRK20.99132692
67TTK0.98450549
68FGFR10.98446707
69PTK60.98015058
70CCNB10.94903102
71MAP2K30.94769135
72BRD40.93178112
73TRIB30.92104888
74KSR20.91994306
75MELK0.91993751
76TESK20.91805922
77RPS6KA20.91773221
78ARAF0.89229850
79CDK20.87583339
80TESK10.86581248
81NEK10.85092223
82RPS6KB20.84586922
83CDC42BPA0.83851933
84STK380.83582670
85AURKB0.81723758
86FGFR20.81596373
87PDPK10.81307159
88RET0.81111727
89IRAK20.80600299
90MKNK20.79114121
91MAP3K70.78826467
92AURKA0.76616215
93SIK20.75104440
94MAP3K10.73971196
95MAPK110.73671486
96ATM0.73620865
97CDK10.72915025
98PAK40.72554270
99CDK80.70994701
100RPS6KA10.68743044
101ERBB20.65481295
102PHKG20.65436129
103PHKG10.65436129
104PIM10.65086751
105CAMK1G0.64447664
106RPS6KL10.63113858
107RPS6KC10.63113858
108SIK30.61724980
109CSNK1G10.60895596
110CDK40.60854316
111TNK20.60686371
112PIM20.60415297
113BCR0.60381686
114MAP3K90.59979216
115PAK20.58782700
116CSK0.57604501
117BRSK10.57262867
118GSK3A0.56758157
119CDK180.56610815
120CAMKK10.55544110
121CDK11A0.55460983
122ALK0.54682528
123CDK150.53808856
124PLK30.53690100
125CSNK1G30.52998528
126MAP2K20.50101254
127LIMK10.49993219
128TAOK20.48946035
129STK30.46657641
130RPS6KA60.46006298
131CSNK1A1L0.45639519
132MAPK120.45380585
133RPS6KB10.45115030
134MAP3K30.44643739
135PDGFRB0.43994760
136CDK140.43099138
137ILK0.42644425
138MAPK130.42532045
139MAPK140.41885958
140MOS0.41585417
141PRKAA10.41192491
142HIPK20.41091468
143PAK60.39470636
144CSNK2A10.39450566
145MAP3K80.39398124
146MAPK100.39392492
147AKT20.38627451
148SGK30.37764758
149PDK10.37018861
150DMPK0.36897154
151MAPKAPK30.36709627
152TAOK10.36570124
153BRAF0.36187094
154CDK90.35771661
155MAPKAPK20.33222912
156PRKCH0.31659369
157MAPK80.30843045
158SCYL20.30576838
159MAPK70.29088840
160FLT30.27543069
161NME10.26840380
162CSF1R0.26748376

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16344441
2Mismatch repair_Homo sapiens_hsa034304.05264280
3Base excision repair_Homo sapiens_hsa034103.77106125
4Spliceosome_Homo sapiens_hsa030403.37799253
5Cell cycle_Homo sapiens_hsa041102.96009784
6mRNA surveillance pathway_Homo sapiens_hsa030152.92091572
7RNA transport_Homo sapiens_hsa030132.74379497
8Basal cell carcinoma_Homo sapiens_hsa052172.69799636
9Hedgehog signaling pathway_Homo sapiens_hsa043402.54328979
10Notch signaling pathway_Homo sapiens_hsa043302.39191521
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.34439813
12Hippo signaling pathway_Homo sapiens_hsa043902.28259221
13Nucleotide excision repair_Homo sapiens_hsa034202.25111652
14Fanconi anemia pathway_Homo sapiens_hsa034602.18876702
15Fatty acid biosynthesis_Homo sapiens_hsa000612.13009096
16Homologous recombination_Homo sapiens_hsa034402.07713615
17Other glycan degradation_Homo sapiens_hsa005112.04859293
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90121234
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80966214
20Oocyte meiosis_Homo sapiens_hsa041141.78350560
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74751396
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66855907
23Wnt signaling pathway_Homo sapiens_hsa043101.66010113
24Colorectal cancer_Homo sapiens_hsa052101.62134081
25MicroRNAs in cancer_Homo sapiens_hsa052061.56514499
26p53 signaling pathway_Homo sapiens_hsa041151.56312191
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.46340026
28mTOR signaling pathway_Homo sapiens_hsa041501.44132172
29Adherens junction_Homo sapiens_hsa045201.42417325
30Fructose and mannose metabolism_Homo sapiens_hsa000511.39207555
31TGF-beta signaling pathway_Homo sapiens_hsa043501.32609648
32Lysine degradation_Homo sapiens_hsa003101.31889837
33Systemic lupus erythematosus_Homo sapiens_hsa053221.30993564
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28110114
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26617028
36Prion diseases_Homo sapiens_hsa050201.24998953
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24552576
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19928691
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19023980
40Axon guidance_Homo sapiens_hsa043601.18193614
41RNA degradation_Homo sapiens_hsa030181.14768919
42Viral myocarditis_Homo sapiens_hsa054161.14351522
43Chronic myeloid leukemia_Homo sapiens_hsa052201.13577998
44Viral carcinogenesis_Homo sapiens_hsa052031.12429054
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11022118
46Inositol phosphate metabolism_Homo sapiens_hsa005621.10050238
47Basal transcription factors_Homo sapiens_hsa030221.09486932
48One carbon pool by folate_Homo sapiens_hsa006701.08331756
49GnRH signaling pathway_Homo sapiens_hsa049121.05541972
50Bladder cancer_Homo sapiens_hsa052191.04828951
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.04031930
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03017963
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02415953
54Endometrial cancer_Homo sapiens_hsa052131.01763404
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01590037
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00366925
57HTLV-I infection_Homo sapiens_hsa051660.98695684
58Prolactin signaling pathway_Homo sapiens_hsa049170.97600003
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94480830
60Pentose phosphate pathway_Homo sapiens_hsa000300.92670233
61ECM-receptor interaction_Homo sapiens_hsa045120.92194019
62Alcoholism_Homo sapiens_hsa050340.90460074
63Galactose metabolism_Homo sapiens_hsa000520.88314786
64Small cell lung cancer_Homo sapiens_hsa052220.87423533
65B cell receptor signaling pathway_Homo sapiens_hsa046620.86270584
66Dorso-ventral axis formation_Homo sapiens_hsa043200.86046055
67Tight junction_Homo sapiens_hsa045300.85265242
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85082192
69Insulin resistance_Homo sapiens_hsa049310.84563930
70Non-homologous end-joining_Homo sapiens_hsa034500.83039258
71Ribosome_Homo sapiens_hsa030100.82886410
72Epstein-Barr virus infection_Homo sapiens_hsa051690.82695441
73Hepatitis C_Homo sapiens_hsa051600.81495803
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80364886
75Long-term potentiation_Homo sapiens_hsa047200.78822112
76Sulfur relay system_Homo sapiens_hsa041220.78430399
77Pathways in cancer_Homo sapiens_hsa052000.76729965
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.76203489
79VEGF signaling pathway_Homo sapiens_hsa043700.75330409
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74663558
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.74405359
82Pyrimidine metabolism_Homo sapiens_hsa002400.74275334
83Gap junction_Homo sapiens_hsa045400.73119636
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.72341131
85Proteoglycans in cancer_Homo sapiens_hsa052050.71946369
86Biosynthesis of amino acids_Homo sapiens_hsa012300.71091212
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69714229
88Vibrio cholerae infection_Homo sapiens_hsa051100.69692821
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68717591
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.67782909
91Shigellosis_Homo sapiens_hsa051310.67077526
92Apoptosis_Homo sapiens_hsa042100.64717035
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63872861
94Non-small cell lung cancer_Homo sapiens_hsa052230.63294153
95Melanogenesis_Homo sapiens_hsa049160.63171829
96Vitamin B6 metabolism_Homo sapiens_hsa007500.62749257
97RNA polymerase_Homo sapiens_hsa030200.62470091
98ErbB signaling pathway_Homo sapiens_hsa040120.62104279
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61855029
100Pancreatic cancer_Homo sapiens_hsa052120.61612553
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59662087
102Amoebiasis_Homo sapiens_hsa051460.58694448
103AMPK signaling pathway_Homo sapiens_hsa041520.58123790
104Circadian rhythm_Homo sapiens_hsa047100.57539521
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55627087
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55313088
107Phenylalanine metabolism_Homo sapiens_hsa003600.54331452
108Type II diabetes mellitus_Homo sapiens_hsa049300.53933893
109HIF-1 signaling pathway_Homo sapiens_hsa040660.52487241
110Prostate cancer_Homo sapiens_hsa052150.52370707
111Herpes simplex infection_Homo sapiens_hsa051680.52320671
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50009806
113N-Glycan biosynthesis_Homo sapiens_hsa005100.49672322
114Dilated cardiomyopathy_Homo sapiens_hsa054140.49630342
115Oxytocin signaling pathway_Homo sapiens_hsa049210.49384500
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48628312
117Glioma_Homo sapiens_hsa052140.48396836
118Cholinergic synapse_Homo sapiens_hsa047250.47361219
119Proteasome_Homo sapiens_hsa030500.47176593
120Thyroid cancer_Homo sapiens_hsa052160.47076120
121Bile secretion_Homo sapiens_hsa049760.46814826
122Lysosome_Homo sapiens_hsa041420.45493017
123Renal cell carcinoma_Homo sapiens_hsa052110.44983948
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44782451
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40512733
126Choline metabolism in cancer_Homo sapiens_hsa052310.39706853
127Insulin signaling pathway_Homo sapiens_hsa049100.39064798
128Hepatitis B_Homo sapiens_hsa051610.37812385
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35757201
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.35663566
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33967615
132Focal adhesion_Homo sapiens_hsa045100.33456170
133Estrogen signaling pathway_Homo sapiens_hsa049150.33436611
134Melanoma_Homo sapiens_hsa052180.33325909
135MAPK signaling pathway_Homo sapiens_hsa040100.30176528
136Arginine and proline metabolism_Homo sapiens_hsa003300.29476706
137Acute myeloid leukemia_Homo sapiens_hsa052210.29210601
138Endocytosis_Homo sapiens_hsa041440.27975699
139Rap1 signaling pathway_Homo sapiens_hsa040150.27668105
140Selenocompound metabolism_Homo sapiens_hsa004500.24837971
141FoxO signaling pathway_Homo sapiens_hsa040680.23642054
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21520740
143Legionellosis_Homo sapiens_hsa051340.20650040
144Glucagon signaling pathway_Homo sapiens_hsa049220.19543829

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