ZFP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.42858722
2aggressive behavior (GO:0002118)5.24927995
3mitotic metaphase plate congression (GO:0007080)4.97619195
4hyperosmotic salinity response (GO:0042538)4.89840127
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.89556862
6cell wall macromolecule catabolic process (GO:0016998)4.68573121
7negative regulation of B cell apoptotic process (GO:0002903)4.58425103
8nuclear pore complex assembly (GO:0051292)4.44626453
9nuclear pore organization (GO:0006999)4.26583115
10positive regulation of prostaglandin secretion (GO:0032308)4.21330712
11metaphase plate congression (GO:0051310)4.18625320
12histone H2A monoubiquitination (GO:0035518)4.18409466
13cell wall macromolecule metabolic process (GO:0044036)4.18161965
14pseudouridine synthesis (GO:0001522)4.14407753
15regulation of hippo signaling (GO:0035330)4.12233949
16mitotic sister chromatid segregation (GO:0000070)4.10531056
17regulation of B cell apoptotic process (GO:0002902)4.09669349
18mitotic nuclear envelope disassembly (GO:0007077)4.08286022
19paraxial mesoderm development (GO:0048339)4.03975637
20piRNA metabolic process (GO:0034587)4.03148775
21protein K6-linked ubiquitination (GO:0085020)4.00998366
22positive regulation of antigen processing and presentation (GO:0002579)3.97364141
23pyrimidine nucleotide catabolic process (GO:0006244)3.93073113
24mitotic chromosome condensation (GO:0007076)3.89215756
25establishment of chromosome localization (GO:0051303)3.87788994
26deoxyribose phosphate catabolic process (GO:0046386)3.85357878
27membrane disassembly (GO:0030397)3.82958343
28nuclear envelope disassembly (GO:0051081)3.82958343
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.80525595
30regulation of posttranscriptional gene silencing (GO:0060147)3.79896506
31regulation of gene silencing by miRNA (GO:0060964)3.79896506
32regulation of gene silencing by RNA (GO:0060966)3.79896506
33kinetochore assembly (GO:0051382)3.79376421
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.75606447
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75606447
36sister chromatid segregation (GO:0000819)3.70616539
37nucleoside transport (GO:0015858)3.69720169
38kinetochore organization (GO:0051383)3.67722247
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67266885
40protein localization to kinetochore (GO:0034501)3.64890966
41negative regulation of histone methylation (GO:0031061)3.64436800
42immunoglobulin mediated immune response (GO:0016064)3.64340468
43regulation of telomere maintenance via telomerase (GO:0032210)3.63201564
44rRNA modification (GO:0000154)3.62555979
45ribosomal small subunit assembly (GO:0000028)3.62372367
46negative regulation of meiosis (GO:0045835)3.60095131
47DNA replication-dependent nucleosome assembly (GO:0006335)3.59088670
48DNA replication-dependent nucleosome organization (GO:0034723)3.59088670
49regulation of sister chromatid cohesion (GO:0007063)3.58265729
50deoxyribonucleotide catabolic process (GO:0009264)3.56392207
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55505369
52seminiferous tubule development (GO:0072520)3.54216303
53regulation of spindle organization (GO:0090224)3.51813482
54nucleotide salvage (GO:0043173)3.44618973
55purine nucleotide salvage (GO:0032261)3.43096954
56attachment of spindle microtubules to kinetochore (GO:0008608)3.42430230
57notochord development (GO:0030903)3.39383702
58regulation of antigen processing and presentation (GO:0002577)3.37081069
59pore complex assembly (GO:0046931)3.36610856
60DNA replication checkpoint (GO:0000076)3.33662119
61spindle checkpoint (GO:0031577)3.33178879
62regulation of prostaglandin secretion (GO:0032306)3.32559172
63regulation of translation in response to stress (GO:0043555)3.32505677
64microtubule depolymerization (GO:0007019)3.28090363
65maturation of 5.8S rRNA (GO:0000460)3.28009984
66regulation of helicase activity (GO:0051095)3.26148773
67female gonad development (GO:0008585)3.25916841
68regulation of centriole replication (GO:0046599)3.25496757
69negative regulation of chromosome segregation (GO:0051985)3.25309647
70regulation of DNA methylation (GO:0044030)3.25195487
71peptidyl-histidine modification (GO:0018202)3.24460527
72meiotic chromosome segregation (GO:0045132)3.24262820
73mitotic sister chromatid cohesion (GO:0007064)3.22324361
74regulation of chromosome segregation (GO:0051983)3.22060934
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22054537
76mismatch repair (GO:0006298)3.19414786
77positive regulation of chromosome segregation (GO:0051984)3.19288933
78regulation of mitotic spindle organization (GO:0060236)3.19162342
79female mating behavior (GO:0060180)3.18897544
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.18879139
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18879139
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18879139
83negative regulation of sister chromatid segregation (GO:0033046)3.18879139
84adenine nucleotide transport (GO:0051503)3.18371235
85chromatin remodeling at centromere (GO:0031055)3.18186072
86mitotic spindle checkpoint (GO:0071174)3.18162158
87DNA replication initiation (GO:0006270)3.17950410
88chromosome segregation (GO:0007059)3.16777495
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15520733
90protein localization to chromosome, centromeric region (GO:0071459)3.15235916
91positive regulation of mitotic sister chromatid separation (GO:1901970)3.14463373
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14463373
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14463373
94regulation of female receptivity (GO:0045924)3.13098231
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12931851
96purine ribonucleotide transport (GO:0015868)3.12825398
97histone H2A ubiquitination (GO:0033522)3.12218277
98B cell mediated immunity (GO:0019724)3.11306584
99mitotic spindle assembly checkpoint (GO:0007094)3.10714526
100CENP-A containing nucleosome assembly (GO:0034080)3.09006552
101regulation of mitotic sister chromatid separation (GO:0010965)3.08447744
102regulation of mitotic sister chromatid segregation (GO:0033047)3.08447744
103regulation of sister chromatid segregation (GO:0033045)3.08447744
104spindle assembly checkpoint (GO:0071173)3.07667171
105DNA replication-independent nucleosome organization (GO:0034724)3.07660298
106DNA replication-independent nucleosome assembly (GO:0006336)3.07660298
107sleep (GO:0030431)3.07021452
108pre-miRNA processing (GO:0031054)3.06627255
109regulation of centrosome cycle (GO:0046605)3.06212246
110valine metabolic process (GO:0006573)3.06104352
111histone H4-K12 acetylation (GO:0043983)3.05715828
112female gamete generation (GO:0007292)3.05650454
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04550595
114ADP metabolic process (GO:0046031)3.01570424
115regulation of double-strand break repair via homologous recombination (GO:0010569)2.99809291
116AMP metabolic process (GO:0046033)2.97746017
117regulation of histone H3-K9 methylation (GO:0051570)2.97143657
118response to interferon-beta (GO:0035456)2.97003503
119nucleoside transmembrane transport (GO:1901642)2.95654782
120histone exchange (GO:0043486)2.95250967
121protein localization to chromosome (GO:0034502)2.94490138
122DNA methylation involved in gamete generation (GO:0043046)2.94120451
123gene silencing by RNA (GO:0031047)2.93845098
124regulation of retinoic acid receptor signaling pathway (GO:0048385)2.93773702
125regulation of histone H3-K27 methylation (GO:0061085)2.93378537
126nuclear envelope organization (GO:0006998)2.92647341
127histone arginine methylation (GO:0034969)2.92299709
128regulation of exit from mitosis (GO:0007096)2.92137818
129DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91945190
130regulation of meiosis I (GO:0060631)2.91628359
131DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90806813
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.90587909
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88907719
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.87704767
135grooming behavior (GO:0007625)2.87262108
136mitochondrial RNA metabolic process (GO:0000959)2.84161867
137meiotic cell cycle (GO:0051321)2.83881967
138positive regulation of B cell differentiation (GO:0045579)2.83446814
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83385606
140negative regulation of chromosome organization (GO:2001251)2.82384724
141base-excision repair, AP site formation (GO:0006285)2.82207358
142replication fork processing (GO:0031297)2.82001778
143negative regulation of nuclear division (GO:0051784)2.80688907
144NAD biosynthetic process (GO:0009435)2.79396001
1452-oxoglutarate metabolic process (GO:0006103)2.79088219
146cytochrome complex assembly (GO:0017004)2.75733352
147tRNA modification (GO:0006400)2.72210570
148phosphatidylglycerol biosynthetic process (GO:0006655)2.70838489
149chaperone-mediated protein transport (GO:0072321)2.69255253
150positive regulation of icosanoid secretion (GO:0032305)2.61299387
151pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.59483604
152aerobic respiration (GO:0009060)2.58432280
153detection of bacterium (GO:0016045)2.56207164
154pentose-phosphate shunt (GO:0006098)2.56061105
155purine deoxyribonucleotide catabolic process (GO:0009155)2.55744202
156nucleoside salvage (GO:0043174)2.55387564
157tryptophan metabolic process (GO:0006568)2.55358543
158transcription elongation from RNA polymerase III promoter (GO:0006385)2.55222281
159termination of RNA polymerase III transcription (GO:0006386)2.55222281
160cellular response to zinc ion (GO:0071294)2.53154536
161oxidative phosphorylation (GO:0006119)2.52283407
162oxaloacetate metabolic process (GO:0006107)2.52110908
163negative regulation of erythrocyte differentiation (GO:0045647)2.51422319
164nucleobase biosynthetic process (GO:0046112)2.50628418
165pentose metabolic process (GO:0019321)2.50166116
166determination of adult lifespan (GO:0008340)2.49200822
167deoxyribose phosphate metabolic process (GO:0019692)2.48875815
168cellular response to cadmium ion (GO:0071276)2.46111008
169mitochondrial respiratory chain complex assembly (GO:0033108)2.45441313
170negative regulation of lymphocyte apoptotic process (GO:0070229)2.45432895
171protein complex biogenesis (GO:0070271)2.45300929
172response to host immune response (GO:0052572)2.42863867
173response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42863867
174proteasome assembly (GO:0043248)2.42171998
175regulation of mitochondrial translation (GO:0070129)2.42046499
176mitochondrial fusion (GO:0008053)2.41687800
177DNA dealkylation (GO:0035510)2.41133073
178endothelium development (GO:0003158)2.41132278
179ribosome assembly (GO:0042255)2.41126547
180NADPH regeneration (GO:0006740)2.39273270
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38456597
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38456597
183ubiquinone biosynthetic process (GO:0006744)2.38186144
184rRNA catabolic process (GO:0016075)2.37304639
185protein-cofactor linkage (GO:0018065)2.37222153
186ncRNA 3-end processing (GO:0043628)2.37081168
187branched-chain amino acid metabolic process (GO:0009081)2.37043688
188regulation of penile erection (GO:0060405)2.36976895
189tRNA processing (GO:0008033)2.36228221
190apoptotic process involved in morphogenesis (GO:0060561)2.36077396
191establishment of protein localization to mitochondrial membrane (GO:0090151)2.36062718
192positive regulation of fatty acid transport (GO:2000193)2.35933315
193DNA double-strand break processing (GO:0000729)2.34991637
194heme biosynthetic process (GO:0006783)2.34617006
195positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.34377097
196detection of other organism (GO:0098543)2.34370514
197pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.34030883
198branched-chain amino acid catabolic process (GO:0009083)2.33582396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31624133
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.86589391
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.62303831
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.67173786
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43163832
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40046967
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.13690304
8SCL_19346495_ChIP-Seq_HPC-7_Human2.99457528
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.99375116
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89836131
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89415873
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.82805935
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.70680638
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.62475994
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60022612
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.55430978
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55228093
18* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.54912790
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50757105
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50757105
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50757105
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.47288789
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39356995
24* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.39034308
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35219860
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.35104441
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34960581
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34768906
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24934297
30* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.22301110
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.18437133
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17876958
33AR_21909140_ChIP-Seq_LNCAP_Human2.17442595
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15995019
35* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.13001010
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09377128
37* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08712351
38* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.03793999
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03325133
40SOX2_18555785_ChIP-Seq_MESCs_Mouse2.00620270
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95914023
42FOXP3_21729870_ChIP-Seq_TREG_Human1.92588528
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89808236
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.85310379
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82686794
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82329330
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81913932
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80601908
49* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80333141
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79530065
51MYC_22102868_ChIP-Seq_BL_Human1.77901751
52* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.75496533
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72760764
54* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.72155047
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65418212
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64979093
57POU5F1_16518401_ChIP-PET_MESCs_Mouse1.62392751
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61666241
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58632367
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56493430
61SPI1_23547873_ChIP-Seq_NB4_Human1.53825278
62VDR_21846776_ChIP-Seq_THP-1_Human1.53364989
63* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53299595
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52795035
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52642562
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.51621034
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51317679
68BCL6_27268052_Chip-Seq_Bcells_Human1.50057535
69VDR_23849224_ChIP-Seq_CD4+_Human1.49439735
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49374986
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48541212
72* NANOG_21062744_ChIP-ChIP_HESCs_Human1.46342672
73* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.46010237
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42671206
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42156911
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42042274
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.41961033
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41487317
79BCOR_27268052_Chip-Seq_Bcells_Human1.41154295
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40217813
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.40071205
82DCP1A_22483619_ChIP-Seq_HELA_Human1.39912067
83* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39036499
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38167308
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35591353
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34840127
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.34353473
88* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33465965
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33093396
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32839816
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30399344
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30128780
93* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28676892
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27813667
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27121995
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26020111
97* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22807624
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21930540
99MYB_26560356_Chip-Seq_TH2_Human1.21895521
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21849748
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.20888783
102* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20620229
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20271781
104* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19884829
105STAT1_20625510_ChIP-Seq_HELA_Human1.19550137
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19126497
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18694993
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17964815
109* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17805886
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.17723876
111PHF8_20622854_ChIP-Seq_HELA_Human1.17490567
112* KAP1_27257070_Chip-Seq_ESCs_Mouse1.17104315
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.16439843
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16309731
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15091009
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14090488
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14007967
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13971262
119XRN2_22483619_ChIP-Seq_HELA_Human1.13723003
120P68_20966046_ChIP-Seq_HELA_Human1.13438787
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.13120439
122KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11024482
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09609003
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09606492
125P300_27268052_Chip-Seq_Bcells_Human1.09386639
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09232743
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09128601
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08212274
129NOTCH1_21737748_ChIP-Seq_TLL_Human1.07586861
130* NANOG_16518401_ChIP-PET_MESCs_Mouse1.07076569
131TTF2_22483619_ChIP-Seq_HELA_Human1.06818544
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06251584
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05000254
134E2F1_20622854_ChIP-Seq_HELA_Human1.04839430
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03923176
136* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02954891
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.02944292
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02311538
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02247790
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02226785
141* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02173935
142CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01974575
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01661372
144STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00455203
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98772282
146VDR_24763502_ChIP-Seq_THP-1_Human0.98370949
147SA1_27219007_Chip-Seq_Bcells_Human0.98007139
148GABP_19822575_ChIP-Seq_HepG2_Human0.97728086
149* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97461348
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96883563
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96297238
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96146008
153KDM5A_27292631_Chip-Seq_BREAST_Human0.95933126
154MYC_18940864_ChIP-ChIP_HL60_Human0.95720388
155SA1_27219007_Chip-Seq_ERYTHROID_Human0.95308978
156CIITA_25753668_ChIP-Seq_RAJI_Human0.95263749
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94907889
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.94511674
159CTCF_20526341_ChIP-Seq_ESCs_Human0.93950090
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93729663
161NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93707355
162FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92510760
163TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91323819
164FUS_26573619_Chip-Seq_HEK293_Human0.90724816
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.89511665
166TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89378803
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.88397374
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86682736
169* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84291393
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82718299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.84148274
2MP0010094_abnormal_chromosome_stability3.79057254
3MP0003111_abnormal_nucleus_morphology3.49771341
4MP0002396_abnormal_hematopoietic_system3.28641069
5MP0004957_abnormal_blastocyst_morpholog3.22247217
6MP0003077_abnormal_cell_cycle3.22114219
7MP0003191_abnormal_cellular_cholesterol3.16147295
8MP0002254_reproductive_system_inflammat3.10895015
9MP0002653_abnormal_ependyma_morphology2.95877478
10MP0001545_abnormal_hematopoietic_system2.93925754
11MP0005397_hematopoietic_system_phenotyp2.93925754
12MP0006292_abnormal_olfactory_placode2.91990446
13* MP0003718_maternal_effect2.86880657
14MP0008057_abnormal_DNA_replication2.74068595
15MP0003123_paternal_imprinting2.66780786
16MP0001835_abnormal_antigen_presentation2.62224807
17MP0009278_abnormal_bone_marrow2.59243437
18MP0008058_abnormal_DNA_repair2.56360878
19MP0005464_abnormal_platelet_physiology2.41144452
20MP0006035_abnormal_mitochondrial_morpho2.35777965
21MP0002148_abnormal_hypersensitivity_rea2.33409024
22MP0008877_abnormal_DNA_methylation2.29856950
23MP0006036_abnormal_mitochondrial_physio2.21041886
24MP0003172_abnormal_lysosome_physiology2.19136405
25MP0009333_abnormal_splenocyte_physiolog2.18184983
26MP0008932_abnormal_embryonic_tissue2.17123083
27* MP0003121_genomic_imprinting2.04228318
28MP0002085_abnormal_embryonic_tissue2.04128031
29MP0003890_abnormal_embryonic-extraembry2.03194735
30MP0008007_abnormal_cellular_replicative2.02513308
31MP0002084_abnormal_developmental_patter1.97382645
32MP0000350_abnormal_cell_proliferation1.94488078
33MP0003119_abnormal_digestive_system1.93615501
34MP0001730_embryonic_growth_arrest1.89765426
35MP0003937_abnormal_limbs/digits/tail_de1.85251098
36MP0004133_heterotaxia1.81622477
37MP0001672_abnormal_embryogenesis/_devel1.79554315
38MP0005380_embryogenesis_phenotype1.79554315
39MP0003186_abnormal_redox_activity1.75589262
40MP0002210_abnormal_sex_determination1.74875105
41MP0002102_abnormal_ear_morphology1.72474861
42MP0005000_abnormal_immune_tolerance1.72462883
43MP0002452_abnormal_antigen_presenting1.70895082
44MP0008875_abnormal_xenobiotic_pharmacok1.69551746
45MP0001697_abnormal_embryo_size1.64799685
46MP0003315_abnormal_perineum_morphology1.64557542
47MP0001819_abnormal_immune_cell1.62125316
48MP0003866_abnormal_defecation1.61033091
49MP0002420_abnormal_adaptive_immunity1.60685374
50MP0001800_abnormal_humoral_immune1.60668427
51MP0002723_abnormal_immune_serum1.60414976
52MP0002138_abnormal_hepatobiliary_system1.58965547
53MP0001986_abnormal_taste_sensitivity1.57771143
54MP0003941_abnormal_skin_development1.55501368
55MP0003755_abnormal_palate_morphology1.55212779
56MP0001119_abnormal_female_reproductive1.54605721
57MP0004808_abnormal_hematopoietic_stem1.54392944
58MP0005025_abnormal_response_to1.53928987
59MP0003300_gastrointestinal_ulcer1.53520797
60MP0009840_abnormal_foam_cell1.52366501
61MP0002249_abnormal_larynx_morphology1.51741817
62MP0002398_abnormal_bone_marrow1.50969840
63MP0003763_abnormal_thymus_physiology1.50089193
64MP0005646_abnormal_pituitary_gland1.49562800
65MP0002419_abnormal_innate_immunity1.48348159
66MP0001929_abnormal_gametogenesis1.47347557
67MP0003984_embryonic_growth_retardation1.45554235
68MP0009764_decreased_sensitivity_to1.45473574
69MP0010030_abnormal_orbit_morphology1.44696050
70MP0008004_abnormal_stomach_pH1.44664906
71MP0003861_abnormal_nervous_system1.44545961
72MP0002088_abnormal_embryonic_growth/wei1.44438942
73MP0000653_abnormal_sex_gland1.43023748
74MP0000689_abnormal_spleen_morphology1.42562494
75MP0008872_abnormal_physiological_respon1.41922896
76MP0003699_abnormal_female_reproductive1.41329375
77MP0002086_abnormal_extraembryonic_tissu1.40322012
78MP0005671_abnormal_response_to1.39827530
79MP0005165_increased_susceptibility_to1.38554613
80MP0003436_decreased_susceptibility_to1.36739818
81MP0008775_abnormal_heart_ventricle1.34992781
82MP0004197_abnormal_fetal_growth/weight/1.34978013
83MP0004264_abnormal_extraembryonic_tissu1.34830918
84MP0001145_abnormal_male_reproductive1.34371946
85MP0001849_ear_inflammation1.33897642
86MP0002429_abnormal_blood_cell1.33429008
87MP0000537_abnormal_urethra_morphology1.32982289
88MP0000716_abnormal_immune_system1.31906026
89MP0003724_increased_susceptibility_to1.31336158
90MP0001968_abnormal_touch/_nociception1.29530929
91MP0010352_gastrointestinal_tract_polyps1.29347638
92MP0001293_anophthalmia1.26891613
93MP0003385_abnormal_body_wall1.26566766
94MP0002019_abnormal_tumor_incidence1.26486103
95MP0000465_gastrointestinal_hemorrhage1.25993864
96MP0005367_renal/urinary_system_phenotyp1.25175952
97MP0000516_abnormal_urinary_system1.25175952
98MP0008260_abnormal_autophagy1.22781343
99MP0001286_abnormal_eye_development1.22179292
100* MP0002080_prenatal_lethality1.21426740
101MP0002722_abnormal_immune_system1.21404341
102MP0005248_abnormal_Harderian_gland1.21153793
103MP0009765_abnormal_xenobiotic_induced1.20913239
104* MP0005395_other_phenotype1.19205363
105MP0001764_abnormal_homeostasis1.19064651
106MP0001881_abnormal_mammary_gland1.17958542
107MP0003935_abnormal_craniofacial_develop1.15227063
108MP0001845_abnormal_inflammatory_respons1.14668550
109MP0002111_abnormal_tail_morphology1.14048523
110MP0000778_abnormal_nervous_system1.14028990
111MP0003646_muscle_fatigue1.11991053
112MP0010307_abnormal_tumor_latency1.11411949
113MP0003786_premature_aging1.10965173
114MP0005387_immune_system_phenotype1.10341627
115MP0001790_abnormal_immune_system1.10341627
116MP0008789_abnormal_olfactory_epithelium1.10238777
117MP0003806_abnormal_nucleotide_metabolis1.09160298
118MP0000432_abnormal_head_morphology1.07998615
119MP0003303_peritoneal_inflammation1.07942527
120MP0010155_abnormal_intestine_physiology1.07689712
121MP0005410_abnormal_fertilization1.06791627
122MP0002405_respiratory_system_inflammati1.06488945
123MP0005451_abnormal_body_composition1.06180887
124MP0002116_abnormal_craniofacial_bone1.06056611
125MP0005075_abnormal_melanosome_morpholog1.04013648
126MP0008995_early_reproductive_senescence1.02899715
127MP0002161_abnormal_fertility/fecundity1.02121629
128MP0005058_abnormal_lysosome_morphology1.02081689
129MP0003567_abnormal_fetal_cardiomyocyte1.01722103
130MP0003075_altered_response_to1.01358069
131MP0008469_abnormal_protein_level1.01026342
132MP0005076_abnormal_cell_differentiation0.99190641
133MP0005257_abnormal_intraocular_pressure0.98423258
134MP0002233_abnormal_nose_morphology0.98299662
135MP0009785_altered_susceptibility_to0.97870121
136MP0005645_abnormal_hypothalamus_physiol0.97192574
137MP0000566_synostosis0.96926255
138MP0009053_abnormal_anal_canal0.96858385
139MP0000049_abnormal_middle_ear0.96185839
140MP0005394_taste/olfaction_phenotype0.95598034
141MP0005499_abnormal_olfactory_system0.95598034
142MP0003942_abnormal_urinary_system0.95229617
143MP0002114_abnormal_axial_skeleton0.93891664
144MP0003705_abnormal_hypodermis_morpholog0.93326219
145MP0000681_abnormal_thyroid_gland0.92462501
146MP0003698_abnormal_male_reproductive0.91489977
147MP0000383_abnormal_hair_follicle0.90117102
148MP0000685_abnormal_immune_system0.90117060
149MP0005389_reproductive_system_phenotype0.89120230
150MP0003136_yellow_coat_color0.88799931
151MP0001919_abnormal_reproductive_system0.87461717
152MP0003938_abnormal_ear_development0.87075288
153MP0000313_abnormal_cell_death0.86948137
154MP0000490_abnormal_crypts_of0.85933675
155MP0002837_dystrophic_cardiac_calcinosis0.84088930
156MP0008961_abnormal_basal_metabolism0.83323472
157MP0000358_abnormal_cell_content/0.83060948
158MP0002932_abnormal_joint_morphology0.82763087
159MP0000703_abnormal_thymus_morphology0.82568218
160MP0000428_abnormal_craniofacial_morphol0.82035119
161MP0001853_heart_inflammation0.81884397
162MP0002177_abnormal_outer_ear0.81533850
163MP0004147_increased_porphyrin_level0.81274509
164MP0005408_hypopigmentation0.81224506
165MP0000534_abnormal_ureter_morphology0.80803635
166MP0008873_increased_physiological_sensi0.80022923
167MP0009703_decreased_birth_body0.79946028
168MP0001529_abnormal_vocalization0.79714607
169MP0002132_abnormal_respiratory_system0.79492959
170MP0009672_abnormal_birth_weight0.77955398
171MP0005319_abnormal_enzyme/_coenzyme0.76664933
172MP0009697_abnormal_copulation0.75867388
173MP0002081_perinatal_lethality0.75620982
174MP0002697_abnormal_eye_size0.74753973
175MP0002006_tumorigenesis0.74515224
176MP0000631_abnormal_neuroendocrine_gland0.74122856
177MP0002127_abnormal_cardiovascular_syste0.74101451
178MP0002152_abnormal_brain_morphology0.73964598
179MP0002925_abnormal_cardiovascular_devel0.73769741
180MP0002796_impaired_skin_barrier0.73521682
181MP0009763_increased_sensitivity_to0.72127809
182MP0003252_abnormal_bile_duct0.71525497
183MP0000015_abnormal_ear_pigmentation0.69770894
184MP0002736_abnormal_nociception_after0.68641753
185MP0005501_abnormal_skin_physiology0.66457623
186MP0001661_extended_life_span0.64461913

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.30402492
2Thrombocytosis (HP:0001894)4.47872597
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46727465
4Chromsome breakage (HP:0040012)4.41752304
5Ependymoma (HP:0002888)4.38063397
6Patellar aplasia (HP:0006443)4.21209817
7Birth length less than 3rd percentile (HP:0003561)4.06287192
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.92000920
9Aplasia/Hypoplasia of the patella (HP:0006498)3.85248806
10Shawl scrotum (HP:0000049)3.80702483
11Hyperglycinuria (HP:0003108)3.79059403
12Breast hypoplasia (HP:0003187)3.54291644
13Papillary thyroid carcinoma (HP:0002895)3.54159518
14Spontaneous abortion (HP:0005268)3.52736640
15Abnormality of the astrocytes (HP:0100707)3.52158884
16Astrocytoma (HP:0009592)3.52158884
17Medulloblastoma (HP:0002885)3.49228152
18Stomatitis (HP:0010280)3.43662325
19Supernumerary spleens (HP:0009799)3.42730613
20Tinnitus (HP:0000360)3.38147252
21Cortical dysplasia (HP:0002539)3.31925976
22Abnormal number of erythroid precursors (HP:0012131)3.27808482
23Agammaglobulinemia (HP:0004432)3.27735786
24Aplastic anemia (HP:0001915)3.14135222
25Panhypogammaglobulinemia (HP:0003139)3.08746209
26Neoplasm of the oral cavity (HP:0100649)3.07325130
27Absent radius (HP:0003974)3.02086005
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.01653198
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.99848936
30Meckel diverticulum (HP:0002245)2.99818060
31Progressive muscle weakness (HP:0003323)2.99521483
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.97492490
33Abnormality of cells of the erythroid lineage (HP:0012130)2.95103968
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94198496
35Hyperglycinemia (HP:0002154)2.93864795
36Abnormality of the ileum (HP:0001549)2.90515586
37Absent forearm bone (HP:0003953)2.89597846
38Aplasia involving forearm bones (HP:0009822)2.89597846
39Rib fusion (HP:0000902)2.82827247
40Increased cerebral lipofuscin (HP:0011813)2.78110052
41Glioma (HP:0009733)2.77624258
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.73610696
43Rhabdomyosarcoma (HP:0002859)2.73335032
44Hepatocellular necrosis (HP:0001404)2.69288812
45Abnormality of chromosome stability (HP:0003220)2.69025195
46Impulsivity (HP:0100710)2.64619406
47Cerebral hypomyelination (HP:0006808)2.63225709
48Abnormality of B cell number (HP:0010975)2.62798092
49Pancytopenia (HP:0001876)2.62496110
50Mediastinal lymphadenopathy (HP:0100721)2.61866013
51Abnormality of the preputium (HP:0100587)2.59363847
52Abnormality of serine family amino acid metabolism (HP:0010894)2.58942011
53Abnormality of glycine metabolism (HP:0010895)2.58942011
54Agnosia (HP:0010524)2.58295794
55Facial hemangioma (HP:0000329)2.56660217
56Elevated erythrocyte sedimentation rate (HP:0003565)2.56609688
57Microvesicular hepatic steatosis (HP:0001414)2.56417659
58Amaurosis fugax (HP:0100576)2.54228396
59Adrenal hypoplasia (HP:0000835)2.53346712
60Acute hepatic failure (HP:0006554)2.51945946
61Breast aplasia (HP:0100783)2.43493654
62Mitochondrial inheritance (HP:0001427)2.42850243
63Abnormal mitochondria in muscle tissue (HP:0008316)2.42824332
64Multiple enchondromatosis (HP:0005701)2.42599122
65Chronic obstructive pulmonary disease (HP:0006510)2.41557253
66Obstructive lung disease (HP:0006536)2.41557253
67Nephroblastoma (Wilms tumor) (HP:0002667)2.40618078
68Asplenia (HP:0001746)2.38764054
69Abnormality of abdominal situs (HP:0011620)2.38233787
70Abdominal situs inversus (HP:0003363)2.38233787
71Fused cervical vertebrae (HP:0002949)2.38018163
72Increased CSF lactate (HP:0002490)2.37779988
73Increased serum lactate (HP:0002151)2.35627681
74Spastic paraparesis (HP:0002313)2.34074606
75Rough bone trabeculation (HP:0100670)2.33974041
76Small intestinal stenosis (HP:0012848)2.32814430
77Duodenal stenosis (HP:0100867)2.32814430
78Ectopic kidney (HP:0000086)2.32187720
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30569438
80Recurrent abscess formation (HP:0002722)2.30310744
81IgM deficiency (HP:0002850)2.30032536
82Acute necrotizing encephalopathy (HP:0006965)2.29117809
83Ragged-red muscle fibers (HP:0003200)2.29098506
84Increased intramyocellular lipid droplets (HP:0012240)2.27141740
85Aplasia/hypoplasia of the humerus (HP:0006507)2.26395416
86Embryonal renal neoplasm (HP:0011794)2.25898093
87Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25777404
88Carpal bone hypoplasia (HP:0001498)2.25382603
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.25279334
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25124639
91Aplasia/Hypoplasia of the breasts (HP:0010311)2.24910727
92Autoimmune hemolytic anemia (HP:0001890)2.24292105
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23697494
94Reduced antithrombin III activity (HP:0001976)2.23123180
95Autoimmune thrombocytopenia (HP:0001973)2.20622545
96Stomach cancer (HP:0012126)2.19102639
97Colitis (HP:0002583)2.18847631
98Lactic acidosis (HP:0003128)2.17633283
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17452003
100Short humerus (HP:0005792)2.16818283
101Ileus (HP:0002595)2.16361046
102Acute encephalopathy (HP:0006846)2.16281819
103Abnormality of T cell physiology (HP:0011840)2.16184599
104Wrist flexion contracture (HP:0001239)2.16020252
105Degeneration of anterior horn cells (HP:0002398)2.15078769
106Abnormality of the anterior horn cell (HP:0006802)2.15078769
107Arterial thrombosis (HP:0004420)2.14367686
108Neoplasm of striated muscle (HP:0009728)2.13787473
109Visual hallucinations (HP:0002367)2.13202112
110Hepatic necrosis (HP:0002605)2.12066317
111Increased IgM level (HP:0003496)2.10241585
112Increased muscle lipid content (HP:0009058)2.09595262
113Abnormality of the prostate (HP:0008775)2.09490383
114Urticaria (HP:0001025)2.09142063
115Bilateral microphthalmos (HP:0007633)2.07591287
116Sloping forehead (HP:0000340)2.07431057
117Abnormal biliary tract physiology (HP:0012439)2.07364262
118Bile duct proliferation (HP:0001408)2.07364262
119Death in infancy (HP:0001522)2.07283358
120High anterior hairline (HP:0009890)2.06882979
121Chest pain (HP:0100749)2.06497201
122Colon cancer (HP:0003003)2.06110530
1233-Methylglutaconic aciduria (HP:0003535)2.05305468
124Palpitations (HP:0001962)2.05282720
125Recurrent fungal infections (HP:0002841)2.02955927
126Vertigo (HP:0002321)2.01006908
127Abnormality of the carotid arteries (HP:0005344)2.00668963
128Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00566979
129Meningitis (HP:0001287)2.00081018
130Thyroid carcinoma (HP:0002890)1.99660865
131Male infertility (HP:0003251)1.98795867
132Neurodegeneration (HP:0002180)1.98328497
133Gastrointestinal inflammation (HP:0004386)1.98026160
134Dicarboxylic aciduria (HP:0003215)1.96276160
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96276160
136Abnormality of the duodenum (HP:0002246)1.96046834
137Selective tooth agenesis (HP:0001592)1.95243994
138Epistaxis (HP:0000421)1.94873409
139Paralysis (HP:0003470)1.93829545
140Abnormality of fatty-acid metabolism (HP:0004359)1.93109803
141Vacuolated lymphocytes (HP:0001922)1.92940332
142Premature ovarian failure (HP:0008209)1.92765208
143Fibular aplasia (HP:0002990)1.92266065
144Progressive visual loss (HP:0000529)1.92088079
145Recurrent viral infections (HP:0004429)1.91747403
146Sandal gap (HP:0001852)1.91028590
147Inflammation of the large intestine (HP:0002037)1.90647692
148Short thumb (HP:0009778)1.90029126
149Progressive macrocephaly (HP:0004481)1.89236713
150Acute lymphatic leukemia (HP:0006721)1.89105696
151Abnormality of lateral ventricle (HP:0030047)1.86700975
152Renal Fanconi syndrome (HP:0001994)1.86298508
153Abnormality of the intervertebral disk (HP:0005108)1.85838036
154Gastrointestinal dysmotility (HP:0002579)1.85706898
155Chronic otitis media (HP:0000389)1.85401655
156CNS demyelination (HP:0007305)1.84713172
157Brushfield spots (HP:0001088)1.84384749
158Gingival bleeding (HP:0000225)1.84000391
159Recurrent cutaneous fungal infections (HP:0011370)1.83701111
160Chronic mucocutaneous candidiasis (HP:0002728)1.83701111
161Myelodysplasia (HP:0002863)1.83612209
162Cafe-au-lait spot (HP:0000957)1.83415548
163Lethargy (HP:0001254)1.81737974
164Spinal muscular atrophy (HP:0007269)1.80333626
165Spina bifida occulta (HP:0003298)1.79950500
166Abnormality of the phalanges of the hallux (HP:0010057)1.78976641
167Esophageal atresia (HP:0002032)1.78392971
168Abnormality of chromosome segregation (HP:0002916)1.77337819
169Diastasis recti (HP:0001540)1.73792243
170Triphalangeal thumb (HP:0001199)1.73672466
171Sparse scalp hair (HP:0002209)1.72685094
172Atrophy/Degeneration involving motor neurons (HP:0007373)1.72269420
173Rectal fistula (HP:0100590)1.71669375
174Rectovaginal fistula (HP:0000143)1.71669375
175Abnormal lung lobation (HP:0002101)1.70538313
176Horseshoe kidney (HP:0000085)1.70316981
177Deviation of the thumb (HP:0009603)1.70168044
178Intestinal fistula (HP:0100819)1.68380667
179Duplicated collecting system (HP:0000081)1.68315776
180Short 1st metacarpal (HP:0010034)1.67646907
181Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67646907
182Volvulus (HP:0002580)1.67442063
183Cystic hygroma (HP:0000476)1.67252992
184Clubbing of toes (HP:0100760)1.66778958
185Heterotopia (HP:0002282)1.66556691
186Supernumerary bones of the axial skeleton (HP:0009144)1.65708015
187Gastrointestinal atresia (HP:0002589)1.64884307
188Oral leukoplakia (HP:0002745)1.64763550
189Tracheoesophageal fistula (HP:0002575)1.62929559
190Supernumerary ribs (HP:0005815)1.62861016
191Abnormality of the labia (HP:0000058)1.61584179
192Capillary hemangiomas (HP:0005306)1.59944109
193Absent thumb (HP:0009777)1.59313109
194Septo-optic dysplasia (HP:0100842)1.58809797
195Abnormal number of incisors (HP:0011064)1.56893818
196Flat capital femoral epiphysis (HP:0003370)1.56776799
197Biliary tract neoplasm (HP:0100574)1.56605984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.43927432
2VRK24.04748082
3CDK123.46256048
4CDC73.35454985
5LATS23.35274870
6MAP3K133.31655588
7LATS13.18723504
8STK38L3.08971377
9TTK3.07212780
10NME22.98535249
11LMTK22.97526021
12PLK42.87899548
13EPHA22.75073640
14BCKDK2.68973605
15MAP3K62.59086853
16EIF2AK32.44204887
17KDR2.42827541
18ERBB42.39001002
19AKT32.31770920
20CHEK22.31476460
21FES2.24502773
22MAP3K142.05055953
23BRAF2.04985885
24SRPK12.01951378
25DYRK22.01560968
26KIT1.99568557
27PHKG11.87206739
28PHKG21.87206739
29BUB11.85997683
30PLK11.85850329
31MARK11.80719667
32STK161.80070436
33SCYL21.79188298
34NEK11.78548266
35TEC1.76833722
36WEE11.74972381
37MAP4K11.74059758
38NEK21.71568749
39CSF1R1.71541004
40NUAK11.70663467
41MST41.70541249
42PLK31.70508836
43JAK31.60847692
44BTK1.60831773
45CDK71.46237203
46MAP3K91.45984038
47EEF2K1.45823734
48PIM21.42896674
49CHEK11.40978613
50MAP3K41.40416968
51IKBKB1.40226364
52ACVR1B1.36219331
53TYRO31.35566298
54RPS6KB21.34355785
55ITK1.33676847
56FLT31.33422848
57BRD41.31298312
58MAP2K21.30820749
59VRK11.29585055
60ATR1.28760577
61STK31.26389857
62MAPK131.23776658
63TBK11.22985818
64SMG11.22327469
65PAK61.19246588
66AURKA1.17717457
67CDK81.16675906
68TNK21.15943225
69ATM1.11890851
70PDK21.10613239
71MAP3K71.08519555
72BMX1.07629802
73YES11.05234754
74AURKB1.04976303
75KSR11.03712245
76EIF2AK11.02333922
77MELK0.97885534
78CDK190.97021260
79OXSR10.96152302
80TAOK20.95902425
81MKNK10.92406445
82CDK20.91288670
83MAPKAPK30.90687997
84PRKCQ0.90442821
85MKNK20.89817659
86MAP2K30.86684099
87NTRK20.84392525
88TSSK60.82785062
89PRKG20.82120142
90CDK10.81420360
91MAP2K70.80477176
92PNCK0.79586755
93PASK0.79066419
94FRK0.78369961
95PIM10.77994743
96ERN10.77233970
97SYK0.76843274
98MAP3K80.76141039
99RAF10.74960911
100KSR20.74596371
101PRKD30.72710166
102LYN0.70391281
103CSNK1D0.69227675
104SGK20.69024097
105DAPK10.68970884
106BCR0.68813313
107CDK40.67483874
108LCK0.66338737
109ABL20.65416256
110PRKCI0.65286593
111HCK0.63532379
112GRK10.63369282
113TAOK10.62896050
114PLK20.62889241
115MATK0.62453451
116IKBKE0.61704984
117WNK30.61457527
118DYRK30.60920367
119STK240.59740760
120RIPK40.59697210
121CSNK1E0.59395595
122MTOR0.59298034
123TGFBR10.57553233
124MAP3K10.57302158
125MAP3K110.56822513
126TXK0.56422669
127TRPM70.55953401
128MAP2K60.55530309
129ZAK0.55162463
130MAP3K50.55132412
131ERBB30.54592743
132EPHA40.54553619
133TIE10.54377406
134DAPK30.51767843
135MUSK0.51241082
136MAP4K20.50764227
137PAK10.50691942
138PRKCD0.50432312
139STK380.50400652
140PRPF4B0.50140727
141STK40.49775628
142GSK3B0.48995550
143LIMK10.48361597
144TAOK30.47844851
145MOS0.47019395
146GRK60.46102586
147STK100.45927464
148NME10.44978909
149FGR0.44336665
150MAPK140.43574997
151AKT10.43506429
152MAPK100.42458267
153CSNK1G10.41637692
154ALK0.41228878
155EIF2AK20.41088022
156GRK70.40587639
157RPS6KL10.37831811
158RPS6KC10.37831811
159EPHB20.36621636
160CDK30.34632350
161PRKDC0.34629387
162PIK3CA0.34534696
163RPS6KA60.34096703
164CSNK1G30.33802208
165TAF10.33413476
166TESK20.33101638
167BRSK10.33101567
168BRSK20.32750036
169RPS6KA50.32445620
170RPS6KA10.32261215
171CSNK2A10.31330590
172MAPK80.31266201
173MAPK10.31229901
174SGK4940.31147950
175SGK2230.31147950
176IGF1R0.26651098
177CSNK2A20.24490757
178CSNK1G20.24085348
179PRKCA0.23299864
180TLK10.20041055

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.19398386
2Cell cycle_Homo sapiens_hsa041103.59543854
3DNA replication_Homo sapiens_hsa030303.48232568
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43306114
5RNA transport_Homo sapiens_hsa030133.41547719
6Fanconi anemia pathway_Homo sapiens_hsa034603.21840641
7Homologous recombination_Homo sapiens_hsa034402.98555860
8Basal transcription factors_Homo sapiens_hsa030222.98550301
9Asthma_Homo sapiens_hsa053102.84958017
10Base excision repair_Homo sapiens_hsa034102.83376753
11Ribosome_Homo sapiens_hsa030102.73156567
12Allograft rejection_Homo sapiens_hsa053302.70682987
13Autoimmune thyroid disease_Homo sapiens_hsa053202.67070006
14Spliceosome_Homo sapiens_hsa030402.62784386
15RNA degradation_Homo sapiens_hsa030182.60902416
16Graft-versus-host disease_Homo sapiens_hsa053322.57765804
17Nucleotide excision repair_Homo sapiens_hsa034202.53212319
18RNA polymerase_Homo sapiens_hsa030202.42108846
19One carbon pool by folate_Homo sapiens_hsa006702.41986503
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38620862
21mRNA surveillance pathway_Homo sapiens_hsa030152.34266619
22Non-homologous end-joining_Homo sapiens_hsa034502.32954347
23Intestinal immune network for IgA production_Homo sapiens_hsa046722.25486043
24Type I diabetes mellitus_Homo sapiens_hsa049402.15833090
25p53 signaling pathway_Homo sapiens_hsa041152.03477351
26Primary immunodeficiency_Homo sapiens_hsa053401.90854671
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88427976
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.85214461
29Other glycan degradation_Homo sapiens_hsa005111.83878312
30Antigen processing and presentation_Homo sapiens_hsa046121.76436454
31Hippo signaling pathway_Homo sapiens_hsa043901.74305506
32Parkinsons disease_Homo sapiens_hsa050121.73686746
33Pentose phosphate pathway_Homo sapiens_hsa000301.72396027
34Oocyte meiosis_Homo sapiens_hsa041141.72280852
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71815380
36Oxidative phosphorylation_Homo sapiens_hsa001901.71103789
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70679460
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55436698
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53923691
40Basal cell carcinoma_Homo sapiens_hsa052171.52725601
41TGF-beta signaling pathway_Homo sapiens_hsa043501.51365977
42Leishmaniasis_Homo sapiens_hsa051401.47567298
43Pyrimidine metabolism_Homo sapiens_hsa002401.47537441
44MicroRNAs in cancer_Homo sapiens_hsa052061.46968466
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45688594
46Carbon metabolism_Homo sapiens_hsa012001.43464126
47Colorectal cancer_Homo sapiens_hsa052101.42155162
48Staphylococcus aureus infection_Homo sapiens_hsa051501.33089413
49Hedgehog signaling pathway_Homo sapiens_hsa043401.30702459
50Rheumatoid arthritis_Homo sapiens_hsa053231.29124591
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25758107
52Notch signaling pathway_Homo sapiens_hsa043301.23012592
53Adherens junction_Homo sapiens_hsa045201.22042587
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19676015
55Tryptophan metabolism_Homo sapiens_hsa003801.17914816
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16112333
57Peroxisome_Homo sapiens_hsa041461.11176436
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09126355
59Folate biosynthesis_Homo sapiens_hsa007901.08361580
60Wnt signaling pathway_Homo sapiens_hsa043101.02955443
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02542166
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02400725
63Glutathione metabolism_Homo sapiens_hsa004800.97922724
64Huntingtons disease_Homo sapiens_hsa050160.97233147
65Endometrial cancer_Homo sapiens_hsa052130.97030528
66Ovarian steroidogenesis_Homo sapiens_hsa049130.92931623
67Thyroid cancer_Homo sapiens_hsa052160.92290695
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89998140
69Purine metabolism_Homo sapiens_hsa002300.89106913
70Tight junction_Homo sapiens_hsa045300.87999244
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85219323
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85209876
73Lysosome_Homo sapiens_hsa041420.84910075
74Proteasome_Homo sapiens_hsa030500.84345328
75Epstein-Barr virus infection_Homo sapiens_hsa051690.81884021
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80192619
77Hematopoietic cell lineage_Homo sapiens_hsa046400.78284169
78mTOR signaling pathway_Homo sapiens_hsa041500.77234244
79HTLV-I infection_Homo sapiens_hsa051660.76816797
80Viral carcinogenesis_Homo sapiens_hsa052030.75538844
81Pancreatic cancer_Homo sapiens_hsa052120.74840440
82Lysine degradation_Homo sapiens_hsa003100.74762884
83Alzheimers disease_Homo sapiens_hsa050100.74549102
84B cell receptor signaling pathway_Homo sapiens_hsa046620.74294210
85Fatty acid elongation_Homo sapiens_hsa000620.74156472
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.72761368
87Pyruvate metabolism_Homo sapiens_hsa006200.71107919
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69833433
89Linoleic acid metabolism_Homo sapiens_hsa005910.68893404
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68807545
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68785088
92Axon guidance_Homo sapiens_hsa043600.66008895
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.65652106
94Pathways in cancer_Homo sapiens_hsa052000.65396934
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.62950206
96Bladder cancer_Homo sapiens_hsa052190.62685711
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60465401
98Tuberculosis_Homo sapiens_hsa051520.60059380
99Influenza A_Homo sapiens_hsa051640.59880847
100Sulfur relay system_Homo sapiens_hsa041220.59753435
101Biosynthesis of amino acids_Homo sapiens_hsa012300.58255542
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58237399
103Melanoma_Homo sapiens_hsa052180.57712581
104ErbB signaling pathway_Homo sapiens_hsa040120.56771629
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56326943
106Cardiac muscle contraction_Homo sapiens_hsa042600.56288370
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.54567940
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54087641
109Small cell lung cancer_Homo sapiens_hsa052220.53386850
110Regulation of autophagy_Homo sapiens_hsa041400.53220254
111Circadian rhythm_Homo sapiens_hsa047100.52982732
112Vitamin B6 metabolism_Homo sapiens_hsa007500.51559844
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51289630
114FoxO signaling pathway_Homo sapiens_hsa040680.50583662
115Metabolic pathways_Homo sapiens_hsa011000.50160624
116Dorso-ventral axis formation_Homo sapiens_hsa043200.48977631
117Toxoplasmosis_Homo sapiens_hsa051450.48489418
118Acute myeloid leukemia_Homo sapiens_hsa052210.48364717
119Renal cell carcinoma_Homo sapiens_hsa052110.47246212
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46718271
121Phototransduction_Homo sapiens_hsa047440.45234466
122Ether lipid metabolism_Homo sapiens_hsa005650.45216960
123Choline metabolism in cancer_Homo sapiens_hsa052310.44185035
124Prostate cancer_Homo sapiens_hsa052150.43771725
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42051730
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41119250
127Propanoate metabolism_Homo sapiens_hsa006400.38977049
128Systemic lupus erythematosus_Homo sapiens_hsa053220.37186101
129Herpes simplex infection_Homo sapiens_hsa051680.36392484
130Ras signaling pathway_Homo sapiens_hsa040140.36297050
131Mineral absorption_Homo sapiens_hsa049780.33326825
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33078614
133Apoptosis_Homo sapiens_hsa042100.32930687
134Prolactin signaling pathway_Homo sapiens_hsa049170.32798726
135Non-small cell lung cancer_Homo sapiens_hsa052230.32155603
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31472690
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31389879
138beta-Alanine metabolism_Homo sapiens_hsa004100.30725981
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.29726333
140Alcoholism_Homo sapiens_hsa050340.29143028
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28762551
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28335530
143Chronic myeloid leukemia_Homo sapiens_hsa052200.28063588
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.26830521
145Viral myocarditis_Homo sapiens_hsa054160.26299806
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.26180598
147Selenocompound metabolism_Homo sapiens_hsa004500.25946307
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24876639
149GnRH signaling pathway_Homo sapiens_hsa049120.24055412
150Platelet activation_Homo sapiens_hsa046110.23204279
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22699561
152Arachidonic acid metabolism_Homo sapiens_hsa005900.22508373
153Rap1 signaling pathway_Homo sapiens_hsa040150.21030330
154MAPK signaling pathway_Homo sapiens_hsa040100.20795973
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19383251
156Shigellosis_Homo sapiens_hsa051310.19015420
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18853668
158Proteoglycans in cancer_Homo sapiens_hsa052050.18763374
159Melanogenesis_Homo sapiens_hsa049160.18473047
160Long-term depression_Homo sapiens_hsa047300.18451823
161Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15723285
162Focal adhesion_Homo sapiens_hsa045100.14993860
163Gap junction_Homo sapiens_hsa045400.14395978
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.13875285
165Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13703465
166Serotonergic synapse_Homo sapiens_hsa047260.11981123

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