ZFP62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.17415380
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.31150973
3nucleobase catabolic process (GO:0046113)6.02208496
4negative regulation of fibroblast apoptotic process (GO:2000270)5.63566867
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.15873165
6keratinocyte development (GO:0003334)5.12007049
7hepatocyte apoptotic process (GO:0097284)5.04717245
8mast cell activation (GO:0045576)5.03418081
9regulation of fibroblast apoptotic process (GO:2000269)4.94253398
10mast cell activation involved in immune response (GO:0002279)4.94203180
11mast cell degranulation (GO:0043303)4.94203180
12cellular extravasation (GO:0045123)4.81427664
13DNA damage response, detection of DNA damage (GO:0042769)4.70250022
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.65722764
15fucose catabolic process (GO:0019317)4.65030313
16L-fucose metabolic process (GO:0042354)4.65030313
17L-fucose catabolic process (GO:0042355)4.65030313
18megakaryocyte development (GO:0035855)4.44938599
19myelin assembly (GO:0032288)4.35865003
20DNA double-strand break processing (GO:0000729)4.31585024
21presynaptic membrane assembly (GO:0097105)4.24509701
22positive regulation of gamma-delta T cell activation (GO:0046645)4.21994928
23regulation of RIG-I signaling pathway (GO:0039535)4.21488640
24definitive hemopoiesis (GO:0060216)4.07486414
25regulation of interleukin-12 biosynthetic process (GO:0045075)4.06024242
26DNA integration (GO:0015074)3.93830047
27regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.92095671
28regulation of histone H3-K9 methylation (GO:0051570)3.82883581
29production of molecular mediator involved in inflammatory response (GO:0002532)3.76134397
30necroptotic process (GO:0070266)3.75907343
31negative regulation of DNA recombination (GO:0045910)3.71924426
32histone H2A acetylation (GO:0043968)3.65390819
33regulation of interferon-beta biosynthetic process (GO:0045357)3.62931389
34atrial cardiac muscle cell action potential (GO:0086014)3.62093347
35CD4-positive, alpha-beta T cell activation (GO:0035710)3.58395428
36dendritic cell chemotaxis (GO:0002407)3.58341342
37T cell migration (GO:0072678)3.55932579
38presynaptic membrane organization (GO:0097090)3.50401379
39positive regulation of B cell differentiation (GO:0045579)3.47054424
40CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.42097913
41cellular response to exogenous dsRNA (GO:0071360)3.41796497
42neural tube formation (GO:0001841)3.40344879
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.38993207
44regulation of translation, ncRNA-mediated (GO:0045974)3.38993207
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38993207
46regulation of centriole replication (GO:0046599)3.35776339
47myeloid cell activation involved in immune response (GO:0002275)3.34121616
48limb bud formation (GO:0060174)3.34006862
49negative regulation of histone methylation (GO:0031061)3.32644556
50microglial cell activation (GO:0001774)3.30371011
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29689576
52positive regulation of chemokine biosynthetic process (GO:0045080)3.29592828
53regulation of MHC class II biosynthetic process (GO:0045346)3.27615683
54regulation of B cell differentiation (GO:0045577)3.25212334
55myeloid dendritic cell activation (GO:0001773)3.22786663
56non-recombinational repair (GO:0000726)3.22670590
57double-strand break repair via nonhomologous end joining (GO:0006303)3.22670590
58olfactory bulb development (GO:0021772)3.21687061
59macrophage activation involved in immune response (GO:0002281)3.21020441
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19521901
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.19521901
62modulation by symbiont of host immune response (GO:0052553)3.19521901
63positive regulation by symbiont of host defense response (GO:0052509)3.19521901
64modulation by symbiont of host defense response (GO:0052031)3.19521901
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19521901
66regulation of helicase activity (GO:0051095)3.17095165
67neuron cell-cell adhesion (GO:0007158)3.16695839
68kinetochore organization (GO:0051383)3.16252706
69central nervous system projection neuron axonogenesis (GO:0021952)3.15748735
70alpha-beta T cell activation (GO:0046631)3.11308657
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.11056655
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11056655
73histone mRNA catabolic process (GO:0071044)3.09368584
74cellular response to zinc ion (GO:0071294)3.05398649
75interkinetic nuclear migration (GO:0022027)3.03859248
76sympathetic nervous system development (GO:0048485)3.02328516
77ventricular trabecula myocardium morphogenesis (GO:0003222)3.00352726
78antigen processing and presentation of endogenous antigen (GO:0019883)3.00144199
79leukocyte degranulation (GO:0043299)2.99916224
80acrosome assembly (GO:0001675)2.98890562
81histone H3-K4 trimethylation (GO:0080182)2.98593933
82mitotic sister chromatid cohesion (GO:0007064)2.98362283
83postsynaptic membrane organization (GO:0001941)2.98179568
84interferon-gamma production (GO:0032609)2.97688390
85axonal fasciculation (GO:0007413)2.97406736
86central nervous system neuron axonogenesis (GO:0021955)2.96806916
87mRNA splice site selection (GO:0006376)2.96502563
88energy homeostasis (GO:0097009)2.95589988
89B cell mediated immunity (GO:0019724)2.95289568
90negative regulation of cAMP-mediated signaling (GO:0043951)2.94690146
91histone H3-K9 methylation (GO:0051567)2.93112227
92positive regulation of DNA-dependent DNA replication (GO:2000105)2.92346961
93respiratory burst (GO:0045730)2.90917291
94negative regulation of neurological system process (GO:0031645)2.90705274
95negative regulation of DNA-dependent DNA replication (GO:2000104)2.90589244
96dendritic cell migration (GO:0036336)2.88569555
97positive regulation of interferon-alpha production (GO:0032727)2.88450419
98positive regulation of interleukin-12 production (GO:0032735)2.87753412
99regulation of B cell receptor signaling pathway (GO:0050855)2.86199914
100regulation of centrosome duplication (GO:0010824)2.85959504
101positive regulation of granulocyte differentiation (GO:0030854)2.85060917
102myeloid leukocyte activation (GO:0002274)2.84717607
103nuclear pore organization (GO:0006999)2.84084813
104pre-miRNA processing (GO:0031054)2.83526110
105regulation of feeding behavior (GO:0060259)2.82802999
106regulation of interferon-alpha production (GO:0032647)2.82661721
107positive regulation of histone methylation (GO:0031062)2.82303989
108postreplication repair (GO:0006301)2.80162795
109neuron recognition (GO:0008038)2.80153892
110phosphorelay signal transduction system (GO:0000160)2.79637961
111nuclear pore complex assembly (GO:0051292)2.78497488
112negative regulation of B cell proliferation (GO:0030889)2.76715737
113snRNA transcription (GO:0009301)2.75091968
114DNA unwinding involved in DNA replication (GO:0006268)2.74281236
115regulation of hexokinase activity (GO:1903299)2.74186972
116regulation of glucokinase activity (GO:0033131)2.74186972
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73612767
118replication fork processing (GO:0031297)2.72518053
119G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.72343472
120positive regulation of interferon-beta production (GO:0032728)2.72172303
121telomere maintenance via telomerase (GO:0007004)2.71976184
122ncRNA catabolic process (GO:0034661)2.71822005
123T-helper 1 type immune response (GO:0042088)2.71785670
124positive regulation of glycolytic process (GO:0045821)2.70729352
125immunoglobulin mediated immune response (GO:0016064)2.69966206
126programmed necrotic cell death (GO:0097300)2.69692594
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69397957
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69397957
129necrotic cell death (GO:0070265)2.67930005
130defense response to protozoan (GO:0042832)2.67881567
131purinergic nucleotide receptor signaling pathway (GO:0035590)2.67107465
132lysosome localization (GO:0032418)2.66934810
133regulation of DNA endoreduplication (GO:0032875)2.66693823
134negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.66528292
135kidney morphogenesis (GO:0060993)2.65759546
136natural killer cell mediated immunity (GO:0002228)2.65477829
137natural killer cell mediated cytotoxicity (GO:0042267)2.65477829
138regulation of gamma-delta T cell activation (GO:0046643)2.65079262
139histone H2B ubiquitination (GO:0033523)2.64549303
140B cell receptor signaling pathway (GO:0050853)2.64526159
141alpha-beta T cell differentiation (GO:0046632)2.62890633
142regulation of centrosome cycle (GO:0046605)2.62396357
143translesion synthesis (GO:0019985)2.61272053
144vocalization behavior (GO:0071625)2.61054716
145germinal center formation (GO:0002467)2.60765490
146macrophage activation (GO:0042116)2.60639772
147regulation of telomere maintenance (GO:0032204)2.59761982
148IMP metabolic process (GO:0046040)2.59636705
149meiotic chromosome segregation (GO:0045132)2.59094809
150myeloid dendritic cell differentiation (GO:0043011)2.58682409
151kinetochore assembly (GO:0051382)2.56571231
152reciprocal meiotic recombination (GO:0007131)2.55830533
153reciprocal DNA recombination (GO:0035825)2.55830533
154rRNA catabolic process (GO:0016075)2.54819909
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54650956
156protein localization to cilium (GO:0061512)2.53862476
157regulation of histone methylation (GO:0031060)2.52775259
158positive regulation of response to biotic stimulus (GO:0002833)2.51683908
159lymph node development (GO:0048535)2.51197108
160glial cell proliferation (GO:0014009)2.51040138
161regulation of gamma-delta T cell differentiation (GO:0045586)2.50787839
162centriole replication (GO:0007099)2.49658744
163positive regulation of respiratory burst (GO:0060267)2.49415686
164intraciliary transport (GO:0042073)2.48359531
165negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.48322196
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48046367
167peptidyl-lysine trimethylation (GO:0018023)2.47174348
168protein polyglutamylation (GO:0018095)2.46427961
169response to methylmercury (GO:0051597)2.45869635
170cardiac right ventricle morphogenesis (GO:0003215)2.45462117
171transcription elongation from RNA polymerase I promoter (GO:0006362)2.44793396
172protein prenylation (GO:0018342)2.44164614
173prenylation (GO:0097354)2.44164614
174RNA-dependent DNA replication (GO:0006278)2.43078196
175respiratory chain complex IV assembly (GO:0008535)2.41853451
176cerebral cortex radially oriented cell migration (GO:0021799)2.40802519
177recombinational repair (GO:0000725)2.39543313
178double-strand break repair via homologous recombination (GO:0000724)2.39367142
179spinal cord development (GO:0021510)2.38713307
180retinal cone cell development (GO:0046549)2.37935812
181ectoderm development (GO:0007398)2.37260780
182regulation of mRNA splicing, via spliceosome (GO:0048024)2.37062016
183membrane disassembly (GO:0030397)2.36207336
184nuclear envelope disassembly (GO:0051081)2.36207336
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35678868
186histone H4-K16 acetylation (GO:0043984)2.34579538
187brain morphogenesis (GO:0048854)2.34473675
188resolution of meiotic recombination intermediates (GO:0000712)2.33770935
189microtubule anchoring (GO:0034453)2.32452929
190cytoplasmic mRNA processing body assembly (GO:0033962)2.31785828
191mitotic nuclear envelope disassembly (GO:0007077)2.31002492
192response to pheromone (GO:0019236)2.30062857
193DNA replication-dependent nucleosome organization (GO:0034723)2.29825562
194DNA replication-dependent nucleosome assembly (GO:0006335)2.29825562
195positive regulation of mRNA processing (GO:0050685)2.29459900
196regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.29089371
197DNA topological change (GO:0006265)2.27946776
198negative regulation of mRNA processing (GO:0050686)2.27622342
199regulation of nuclear cell cycle DNA replication (GO:0033262)2.27178233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51138614
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.86923917
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.24501130
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.12053132
5GATA1_22025678_ChIP-Seq_K562_Human4.03145334
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.02413781
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.37756619
8ZNF274_21170338_ChIP-Seq_K562_Hela3.35356317
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.13661201
10SCL_19346495_ChIP-Seq_HPC-7_Human3.03760392
11GBX2_23144817_ChIP-Seq_PC3_Human2.96829376
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96721014
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.96079368
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94034339
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86654189
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83121103
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71021355
18FUS_26573619_Chip-Seq_HEK293_Human2.58264131
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49751950
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43219291
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42832775
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.41497005
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.35756377
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32719653
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29824799
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20764365
27IGF1R_20145208_ChIP-Seq_DFB_Human2.10078435
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.04245291
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99971235
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98409858
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97191847
32P300_19829295_ChIP-Seq_ESCs_Human1.93107916
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92825754
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90435808
35SPI1_23547873_ChIP-Seq_NB4_Human1.90041455
36RUNX_20019798_ChIP-Seq_JUKART_Human1.88183022
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83554899
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.83376357
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83026845
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.82408874
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75329652
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74164017
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73863854
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73286887
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72278993
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71639388
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69994680
48ELK1_19687146_ChIP-ChIP_HELA_Human1.67301458
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.64711798
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61797014
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61125884
52VDR_22108803_ChIP-Seq_LS180_Human1.59132417
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59103113
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58460490
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58232446
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.56960828
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56904575
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.54855390
59SMAD4_21799915_ChIP-Seq_A2780_Human1.54194890
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51723514
61CIITA_25753668_ChIP-Seq_RAJI_Human1.49649294
62MYB_26560356_Chip-Seq_TH1_Human1.49592471
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48576603
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47258370
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46887038
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46480890
67ER_23166858_ChIP-Seq_MCF-7_Human1.45819638
68MYB_26560356_Chip-Seq_TH2_Human1.45754961
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43147935
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41135729
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37527427
72CBP_20019798_ChIP-Seq_JUKART_Human1.36989406
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36989406
74MAF_26560356_Chip-Seq_TH1_Human1.36536727
75STAT3_23295773_ChIP-Seq_U87_Human1.34624385
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34577096
77EZH2_22144423_ChIP-Seq_EOC_Human1.34367080
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34065706
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.34015749
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33884798
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.33504118
82* PU_27001747_Chip-Seq_BMDM_Mouse1.33013523
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32030857
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31846851
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30961315
86BCAT_22108803_ChIP-Seq_LS180_Human1.29707646
87SPI1_23127762_ChIP-Seq_K562_Human1.28784542
88AR_25329375_ChIP-Seq_VCAP_Human1.28242641
89MYC_18940864_ChIP-ChIP_HL60_Human1.28080271
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28021618
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25338118
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25066137
93IRF1_19129219_ChIP-ChIP_H3396_Human1.24511615
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21883128
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20348437
96TCF4_23295773_ChIP-Seq_U87_Human1.19367698
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18507992
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17192610
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.17069114
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16915662
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16461023
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16461023
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16142617
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16078810
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15674067
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14770910
107EWS_26573619_Chip-Seq_HEK293_Human1.14146581
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14013616
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12967719
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.12051359
111RUNX2_22187159_ChIP-Seq_PCA_Human1.11491100
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.10720824
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09578648
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08968024
115MYC_22102868_ChIP-Seq_BL_Human1.08889066
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08563352
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.07238445
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06876628
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06440918
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06266381
121GATA3_27048872_Chip-Seq_THYMUS_Human1.06141695
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06061516
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05947122
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05375937
125* GATA3_26560356_Chip-Seq_TH2_Human1.05225753
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03917750
127SOX2_16153702_ChIP-ChIP_HESCs_Human1.03519529
128ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03015716
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02948937
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02840419
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.01994193
132P53_22387025_ChIP-Seq_ESCs_Mouse1.01609536
133VDR_24763502_ChIP-Seq_THP-1_Human1.01492752
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99536900
135RNF2_27304074_Chip-Seq_NSC_Mouse0.98999129
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98845909
137VDR_24787735_ChIP-Seq_THP-1_Human0.98610270
138TCF4_22108803_ChIP-Seq_LS180_Human0.98597797
139VDR_23849224_ChIP-Seq_CD4+_Human0.98177686
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98154123
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97977747
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97705558
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97559439
144* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97210941
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96592931
146P300_18555785_Chip-Seq_ESCs_Mouse0.96083212
147SOX9_26525672_Chip-Seq_HEART_Mouse0.96026765
148TCF7_22412390_ChIP-Seq_EML_Mouse0.96005773
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.94333275
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93111574
151NFE2_27457419_Chip-Seq_LIVER_Mouse0.92761701
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.90929416
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.90891363
154* TP63_19390658_ChIP-ChIP_HaCaT_Human0.87742997
155TAF15_26573619_Chip-Seq_HEK293_Human0.86948152
156VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84045297
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83911510
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80805415
159TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79034080
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77544978
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75656775
162WT1_19549856_ChIP-ChIP_CCG9911_Human0.75384922
163* SALL1_21062744_ChIP-ChIP_HESCs_Human0.73679171
164AR_21909140_ChIP-Seq_LNCAP_Human0.71921550
165SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71677806
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70951315
167GATA1_19941826_ChIP-Seq_K562_Human0.69520962
168VDR_21846776_ChIP-Seq_THP-1_Human0.68905470
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68624631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.61986775
2MP0008057_abnormal_DNA_replication3.82740112
3MP0005075_abnormal_melanosome_morpholog3.65735201
4MP0003787_abnormal_imprinting3.00349956
5MP0005671_abnormal_response_to2.82702906
6MP0002396_abnormal_hematopoietic_system2.77793417
7MP0000685_abnormal_immune_system2.64409864
8MP0001790_abnormal_immune_system2.58522028
9MP0005387_immune_system_phenotype2.58522028
10MP0009697_abnormal_copulation2.56427709
11MP0003880_abnormal_central_pattern2.48281308
12MP0003300_gastrointestinal_ulcer2.47070532
13MP0003763_abnormal_thymus_physiology2.46020307
14MP0004808_abnormal_hematopoietic_stem2.45382527
15MP0009785_altered_susceptibility_to2.44155603
16MP0001800_abnormal_humoral_immune2.30211318
17MP0003436_decreased_susceptibility_to2.28322601
18MP0005464_abnormal_platelet_physiology2.26605419
19MP0002452_abnormal_antigen_presenting2.25087250
20MP0003890_abnormal_embryonic-extraembry2.21249711
21MP0002148_abnormal_hypersensitivity_rea2.20504011
22MP0002398_abnormal_bone_marrow2.20349922
23MP0005000_abnormal_immune_tolerance2.17312347
24MP0002419_abnormal_innate_immunity2.13953895
25MP0002420_abnormal_adaptive_immunity2.12926661
26MP0002751_abnormal_autonomic_nervous2.12351810
27MP0001819_abnormal_immune_cell2.10726167
28MP0006292_abnormal_olfactory_placode2.06767340
29MP0000465_gastrointestinal_hemorrhage2.06587307
30MP0002723_abnormal_immune_serum1.98615225
31MP0008007_abnormal_cellular_replicative1.94483275
32MP0000778_abnormal_nervous_system1.93379581
33MP0010094_abnormal_chromosome_stability1.91981352
34MP0002822_catalepsy1.87411459
35MP0005367_renal/urinary_system_phenotyp1.86354344
36MP0000516_abnormal_urinary_system1.86354344
37MP0000569_abnormal_digit_pigmentation1.85983204
38MP0005025_abnormal_response_to1.83136184
39MP0003718_maternal_effect1.80078697
40MP0003077_abnormal_cell_cycle1.78757578
41MP0000716_abnormal_immune_system1.77830912
42MP0002166_altered_tumor_susceptibility1.73967937
43MP0000371_diluted_coat_color1.60759371
44MP0002722_abnormal_immune_system1.60021710
45MP0002095_abnormal_skin_pigmentation1.59772071
46MP0003123_paternal_imprinting1.59370153
47MP0008789_abnormal_olfactory_epithelium1.58896195
48MP0004043_abnormal_pH_regulation1.58274264
49MP0000689_abnormal_spleen_morphology1.58270891
50MP0000703_abnormal_thymus_morphology1.57009949
51MP0003121_genomic_imprinting1.56824465
52MP0006072_abnormal_retinal_apoptosis1.54024080
53MP0002429_abnormal_blood_cell1.53616292
54MP0006082_CNS_inflammation1.51846342
55MP0004510_myositis1.49457206
56MP0004084_abnormal_cardiac_muscle1.48614819
57MP0001853_heart_inflammation1.48465096
58MP0004885_abnormal_endolymph1.45617474
59MP0001529_abnormal_vocalization1.43702523
60MP0005394_taste/olfaction_phenotype1.40538004
61MP0005499_abnormal_olfactory_system1.40538004
62MP0009333_abnormal_splenocyte_physiolog1.38454584
63MP0010155_abnormal_intestine_physiology1.36811876
64MP0005174_abnormal_tail_pigmentation1.35895886
65MP0002933_joint_inflammation1.35066132
66MP0006054_spinal_hemorrhage1.33825076
67MP0001661_extended_life_span1.33685377
68MP0003755_abnormal_palate_morphology1.33097789
69MP0002075_abnormal_coat/hair_pigmentati1.31826702
70MP0002184_abnormal_innervation1.30647060
71MP0003937_abnormal_limbs/digits/tail_de1.30434349
72MP0004270_analgesia1.29253037
73MP0002234_abnormal_pharynx_morphology1.29112522
74MP0005253_abnormal_eye_physiology1.27594894
75MP0002837_dystrophic_cardiac_calcinosis1.27486014
76MP0008058_abnormal_DNA_repair1.27188817
77MP0002006_tumorigenesis1.26966571
78MP0009703_decreased_birth_body1.26649682
79MP0002233_abnormal_nose_morphology1.24568607
80MP0002736_abnormal_nociception_after1.22429181
81MP0001188_hyperpigmentation1.22250702
82MP0001485_abnormal_pinna_reflex1.21292970
83MP0003861_abnormal_nervous_system1.20624690
84MP0003567_abnormal_fetal_cardiomyocyte1.20411105
85MP0002938_white_spotting1.17515271
86MP0005171_absent_coat_pigmentation1.17213668
87MP0000490_abnormal_crypts_of1.16092569
88MP0003943_abnormal_hepatobiliary_system1.15992520
89MP0000015_abnormal_ear_pigmentation1.15738023
90MP0005397_hematopoietic_system_phenotyp1.15344970
91MP0001545_abnormal_hematopoietic_system1.15344970
92MP0000631_abnormal_neuroendocrine_gland1.14750284
93MP0000427_abnormal_hair_cycle1.14351092
94MP0004197_abnormal_fetal_growth/weight/1.13254765
95MP0001873_stomach_inflammation1.13039655
96MP0003941_abnormal_skin_development1.12914291
97MP0003786_premature_aging1.12466849
98MP0001984_abnormal_olfaction1.12146811
99MP0001845_abnormal_inflammatory_respons1.11307358
100MP0002735_abnormal_chemical_nociception1.11148388
101MP0009672_abnormal_birth_weight1.10548517
102MP0004859_abnormal_synaptic_plasticity1.08084811
103MP0006276_abnormal_autonomic_nervous1.07929074
104MP0001299_abnormal_eye_distance/1.07729706
105MP0001186_pigmentation_phenotype1.06095031
106MP0008877_abnormal_DNA_methylation1.05302154
107MP0002111_abnormal_tail_morphology1.02455248
108MP0004811_abnormal_neuron_physiology1.02313884
109MP0000647_abnormal_sebaceous_gland1.02139979
110MP0005248_abnormal_Harderian_gland1.01886617
111MP0001486_abnormal_startle_reflex1.01690689
112MP0001915_intracranial_hemorrhage1.01164140
113MP0002084_abnormal_developmental_patter1.00424207
114MP0002009_preneoplasia1.00279348
115MP0002638_abnormal_pupillary_reflex1.00278414
116MP0000566_synostosis0.99888670
117MP0005551_abnormal_eye_electrophysiolog0.99706598
118MP0003938_abnormal_ear_development0.99466840
119MP0004133_heterotaxia0.99048514
120MP0001929_abnormal_gametogenesis0.98484170
121MP0010307_abnormal_tumor_latency0.98397252
122MP0000955_abnormal_spinal_cord0.98342364
123MP0000049_abnormal_middle_ear0.97816319
124MP0003111_abnormal_nucleus_morphology0.97515255
125MP0002998_abnormal_bone_remodeling0.97452632
126MP0001286_abnormal_eye_development0.95818752
127MP0000428_abnormal_craniofacial_morphol0.95764956
128MP0002405_respiratory_system_inflammati0.95583684
129MP0010352_gastrointestinal_tract_polyps0.95101023
130MP0003119_abnormal_digestive_system0.94636591
131MP0002152_abnormal_brain_morphology0.94452035
132MP0003935_abnormal_craniofacial_develop0.93764619
133MP0008995_early_reproductive_senescence0.93344721
134MP0002295_abnormal_pulmonary_circulatio0.92727467
135MP0005084_abnormal_gallbladder_morpholo0.92437823
136MP0000858_altered_metastatic_potential0.91728130
137MP0003698_abnormal_male_reproductive0.91340668
138MP0001533_abnormal_skeleton_physiology0.91042253
139MP0002085_abnormal_embryonic_tissue0.90328876
140MP0000653_abnormal_sex_gland0.88562087
141MP0001177_atelectasis0.87645958
142MP0002210_abnormal_sex_determination0.86765143
143MP0008932_abnormal_embryonic_tissue0.85933852
144MP0001145_abnormal_male_reproductive0.85927879
145MP0001879_abnormal_lymphatic_vessel0.85173125
146MP0000350_abnormal_cell_proliferation0.84556406
147MP0003011_delayed_dark_adaptation0.83195781
148MP0005395_other_phenotype0.83129042
149MP0001968_abnormal_touch/_nociception0.81752197
150MP0002102_abnormal_ear_morphology0.80614884
151MP0002752_abnormal_somatic_nervous0.80391551
152MP0001730_embryonic_growth_arrest0.80313207
153MP0001697_abnormal_embryo_size0.80166136
154MP0003724_increased_susceptibility_to0.80152480
155MP0003635_abnormal_synaptic_transmissio0.80115657
156MP0003385_abnormal_body_wall0.78673531
157MP0001672_abnormal_embryogenesis/_devel0.78579010
158MP0005380_embryogenesis_phenotype0.78579010
159MP0002163_abnormal_gland_morphology0.77312693
160MP0002928_abnormal_bile_duct0.75629045
161MP0005503_abnormal_tendon_morphology0.75592431
162MP0001293_anophthalmia0.75104444
163MP0002138_abnormal_hepatobiliary_system0.74581287
164MP0000313_abnormal_cell_death0.73679387
165MP0008469_abnormal_protein_level0.69341742
166MP0002019_abnormal_tumor_incidence0.69232655
167MP0004782_abnormal_surfactant_physiolog0.69178282
168MP0003693_abnormal_embryo_hatching0.66981800
169MP0000767_abnormal_smooth_muscle0.66208920
170MP0003866_abnormal_defecation0.65707273
171MP0003122_maternal_imprinting0.65441943
172MP0001119_abnormal_female_reproductive0.62855409
173MP0009763_increased_sensitivity_to0.62036722
174MP0004947_skin_inflammation0.61971408
175MP0009765_abnormal_xenobiotic_induced0.61193618
176MP0002277_abnormal_respiratory_mucosa0.58563023
177MP0003828_pulmonary_edema0.58457834
178MP0009278_abnormal_bone_marrow0.58045251
179MP0005390_skeleton_phenotype0.56647104
180MP0003795_abnormal_bone_structure0.56235486
181MP0004957_abnormal_blastocyst_morpholog0.55719570

Predicted human phenotypes

RankGene SetZ-score
1Syringomyelia (HP:0003396)6.52306283
2Spinal cord lesions (HP:0100561)6.52306283
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.00571706
4Peripheral hypomyelination (HP:0007182)4.77825515
5Absent frontal sinuses (HP:0002688)4.50156193
6Hypoglycemic seizures (HP:0002173)4.48036744
7Axonal loss (HP:0003447)4.43658292
8Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.39285130
9Visual hallucinations (HP:0002367)4.33432433
10Amyotrophic lateral sclerosis (HP:0007354)4.21034311
11Hyperinsulinemic hypoglycemia (HP:0000825)4.13207915
12Ankle contracture (HP:0006466)4.08581376
13Abnormality of the frontal sinuses (HP:0002687)3.98440936
14Distal arthrogryposis (HP:0005684)3.89040355
15Abnormality of the labia minora (HP:0012880)3.86198455
16Intestinal atresia (HP:0011100)3.82681899
17Broad alveolar ridges (HP:0000187)3.80386234
18Aplasia/Hypoplasia of the sternum (HP:0006714)3.79109392
19Abnormality of the distal phalanges of the toes (HP:0010182)3.69629658
20Spondylolisthesis (HP:0003302)3.58890018
21Hypoglycemic coma (HP:0001325)3.53955044
22Hepatoblastoma (HP:0002884)3.49668602
23Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.49136227
24Premature loss of primary teeth (HP:0006323)3.47944663
25Broad face (HP:0000283)3.33855480
26Adactyly (HP:0009776)3.19296324
27Pancreatic islet-cell hyperplasia (HP:0004510)3.11918530
28Decreased skull ossification (HP:0004331)3.01936027
29Frequent falls (HP:0002359)3.01821899
30Hypothermia (HP:0002045)2.97265974
31Glossoptosis (HP:0000162)2.97111332
32Symptomatic seizures (HP:0011145)2.95863182
33Ependymoma (HP:0002888)2.95777898
34Chromsome breakage (HP:0040012)2.90039774
35Abnormality of the astrocytes (HP:0100707)2.84873937
36Astrocytoma (HP:0009592)2.84873937
37Recurrent viral infections (HP:0004429)2.84372941
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83135127
39Prolonged bleeding time (HP:0003010)2.81762311
40Abnormality of the metopic suture (HP:0005556)2.74353902
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.74346519
42Glioma (HP:0009733)2.71087441
43Hypochromic anemia (HP:0001931)2.68428651
44Sparse scalp hair (HP:0002209)2.66430079
45Short clavicles (HP:0000894)2.64801335
46Abnormality of midbrain morphology (HP:0002418)2.59845640
47Molar tooth sign on MRI (HP:0002419)2.59845640
48Tubulointerstitial nephritis (HP:0001970)2.57068602
49Thrombocytosis (HP:0001894)2.53618595
50Hyperventilation (HP:0002883)2.52330962
51Neoplasm of the adrenal cortex (HP:0100641)2.50405904
52Abnormal platelet volume (HP:0011876)2.50186626
53Ketoacidosis (HP:0001993)2.48958304
54Genetic anticipation (HP:0003743)2.48271796
55Abnormality of skull ossification (HP:0002703)2.48128218
56Agammaglobulinemia (HP:0004432)2.47954842
57Amaurosis fugax (HP:0100576)2.47941581
58Progressive inability to walk (HP:0002505)2.47507953
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.46897121
60Nephronophthisis (HP:0000090)2.46436765
61Abnormality of endocrine pancreas physiology (HP:0012093)2.45690708
62Abnormality of the pancreatic islet cells (HP:0006476)2.45690708
63Epistaxis (HP:0000421)2.45220211
64Drooling (HP:0002307)2.44751258
65Abnormality of the fingertips (HP:0001211)2.43886685
66Myelodysplasia (HP:0002863)2.43381440
67Gingival bleeding (HP:0000225)2.41209575
68IgM deficiency (HP:0002850)2.40131703
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.39055373
70Retrobulbar optic neuritis (HP:0100654)2.37932266
71Optic neuritis (HP:0100653)2.37932266
72Aqueductal stenosis (HP:0002410)2.35290652
73Gastrointestinal atresia (HP:0002589)2.34643111
74High anterior hairline (HP:0009890)2.34233197
75Cortical dysplasia (HP:0002539)2.33410185
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33001562
77Short 4th metacarpal (HP:0010044)2.33001562
78Hypoplastic iliac wings (HP:0002866)2.26243351
79Heterotopia (HP:0002282)2.25700848
80Mediastinal lymphadenopathy (HP:0100721)2.24840894
81Clubbing of toes (HP:0100760)2.24578806
82Prominent metopic ridge (HP:0005487)2.22243244
83Aplasia/Hypoplasia of the clavicles (HP:0006710)2.21482727
84Methylmalonic acidemia (HP:0002912)2.21263420
85Encephalitis (HP:0002383)2.21085532
86Long clavicles (HP:0000890)2.20502678
87Abnormal hair whorl (HP:0010721)2.20371054
88Excessive salivation (HP:0003781)2.19780716
89Hypochromic microcytic anemia (HP:0004840)2.19201155
90Tapered finger (HP:0001182)2.19150118
91Renal hypoplasia (HP:0000089)2.18215034
92Petechiae (HP:0000967)2.17875421
93Long foot (HP:0001833)2.13086700
94Agnosia (HP:0010524)2.13051302
95Abnormality of the renal medulla (HP:0100957)2.12123432
96Increased IgM level (HP:0003496)2.10838301
97Spontaneous hematomas (HP:0007420)2.10470017
98Recurrent fungal infections (HP:0002841)2.09244145
99Pancreatic cysts (HP:0001737)2.08717527
100Myositis (HP:0100614)2.08698170
101Nephroblastoma (Wilms tumor) (HP:0002667)2.08397739
10211 pairs of ribs (HP:0000878)2.06868143
103Hypsarrhythmia (HP:0002521)2.05920536
104Abnormality of the parathyroid morphology (HP:0011766)2.05149978
105Hip dysplasia (HP:0001385)2.03502247
106Keratoconjunctivitis sicca (HP:0001097)2.03201071
107Abnormality of the intervertebral disk (HP:0005108)2.02933781
108Chronic diarrhea (HP:0002028)2.02728097
109Preaxial hand polydactyly (HP:0001177)2.02472815
110Abnormal lung lobation (HP:0002101)2.02099182
111Abnormality of the alveolar ridges (HP:0006477)2.00945607
112Scrotal hypoplasia (HP:0000046)2.00829768
113Oligodactyly (hands) (HP:0001180)1.99929723
114Arterial thrombosis (HP:0004420)1.98775199
115Abnormality of primary teeth (HP:0006481)1.96681456
116Eczematoid dermatitis (HP:0000976)1.96406753
117Volvulus (HP:0002580)1.95558922
118Aplastic anemia (HP:0001915)1.95047897
119EEG with generalized epileptiform discharges (HP:0011198)1.93988551
120Meningitis (HP:0001287)1.93703258
121Tented upper lip vermilion (HP:0010804)1.93523755
122Pancreatic fibrosis (HP:0100732)1.93152272
123Skull defect (HP:0001362)1.92853086
124Truncal obesity (HP:0001956)1.91230631
125Embryonal renal neoplasm (HP:0011794)1.90589676
126Ketosis (HP:0001946)1.90361126
127Osteolytic defects of the hand bones (HP:0009699)1.89785614
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.89785614
129Lissencephaly (HP:0001339)1.88696619
130Dysdiadochokinesis (HP:0002075)1.88367584
131Hepatic necrosis (HP:0002605)1.87951028
132Keratoconjunctivitis (HP:0001096)1.87617909
133Abnormality of T cell physiology (HP:0011840)1.86856183
134Vasculitis (HP:0002633)1.86736113
135Limb hypertonia (HP:0002509)1.86468170
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.86317622
137Rhabdomyosarcoma (HP:0002859)1.86152354
138Medulloblastoma (HP:0002885)1.85900092
139Papillary thyroid carcinoma (HP:0002895)1.85002079
140Chronic hepatic failure (HP:0100626)1.84799361
141Inappropriate behavior (HP:0000719)1.84511006
142Abnormality of T cells (HP:0002843)1.84427162
143Recurrent abscess formation (HP:0002722)1.84006562
144Epileptiform EEG discharges (HP:0011182)1.83911813
145Osteomyelitis (HP:0002754)1.83808056
146Increased mean platelet volume (HP:0011877)1.83706605
147Cellulitis (HP:0100658)1.83008259
148Neoplasm of the oral cavity (HP:0100649)1.82206258
149Gaze-evoked nystagmus (HP:0000640)1.82010037
150Sloping forehead (HP:0000340)1.81320748
151Medial flaring of the eyebrow (HP:0010747)1.81283306
152Genital tract atresia (HP:0001827)1.80893196
153Patellar aplasia (HP:0006443)1.79821095
154Elevated erythrocyte sedimentation rate (HP:0003565)1.79762452
155Broad-based gait (HP:0002136)1.79296418
156Chronic mucocutaneous candidiasis (HP:0002728)1.79119940
157Recurrent cutaneous fungal infections (HP:0011370)1.79119940
158Absent thumb (HP:0009777)1.77942605
159Postaxial hand polydactyly (HP:0001162)1.77473385
160Embryonal neoplasm (HP:0002898)1.77382208
161Mesomelia (HP:0003027)1.77208554
162Panhypogammaglobulinemia (HP:0003139)1.76998951
163Highly arched eyebrow (HP:0002553)1.76313670
164Micropenis (HP:0000054)1.76012130
165Orchitis (HP:0100796)1.75968853
166Disinhibition (HP:0000734)1.75683819
167Colon cancer (HP:0003003)1.75619088
168Periodontitis (HP:0000704)1.75418637
169Abnormality of abdominal situs (HP:0011620)1.75309292
170Abdominal situs inversus (HP:0003363)1.75309292
171Bifid tongue (HP:0010297)1.74280216
172Purpura (HP:0000979)1.73990245
173Recurrent bacterial skin infections (HP:0005406)1.73636644
174Enlarged penis (HP:0000040)1.73557228
175Thick eyebrow (HP:0000574)1.73045320
176Thyroid carcinoma (HP:0002890)1.72921579
177Hypoplastic pelvis (HP:0008839)1.72782858
178Abnormality of chromosome stability (HP:0003220)1.72612201
179Anencephaly (HP:0002323)1.72517084
180Median cleft lip (HP:0000161)1.72453673
181Cupped ear (HP:0000378)1.72151262
182Acute myeloid leukemia (HP:0004808)1.72126694
183Labial hypoplasia (HP:0000066)1.71990134
184Nephrogenic diabetes insipidus (HP:0009806)1.69957255
185Gait imbalance (HP:0002141)1.69634089
186Congenital primary aphakia (HP:0007707)1.67813463
187Focal seizures (HP:0007359)1.67475567
188Aplasia/Hypoplasia of the tongue (HP:0010295)1.67322470
189Hyperglycemia (HP:0003074)1.65843810
190Postaxial foot polydactyly (HP:0001830)1.65794541
191Oligodactyly (HP:0012165)1.65501619
192Biliary tract neoplasm (HP:0100574)1.65490771
193Short 1st metacarpal (HP:0010034)1.64274203
194Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.64274203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG6.38115171
2MAP4K24.57128497
3FRK3.20946866
4TXK3.20121022
5ACVR1B2.95469592
6STK242.82611130
7MARK12.80433482
8MAP3K142.71399084
9KIT2.69838106
10TRIM282.69695994
11CDC72.58336371
12MAP3K42.55367784
13IKBKE2.50709886
14EPHA42.44559547
15NUAK12.42222439
16IKBKB2.26242649
17CASK2.24901408
18WNK32.22562161
19LATS12.22360143
20MAP4K12.19717464
21RPS6KA41.91517023
22CHUK1.84705570
23NTRK31.78198589
24TSSK61.74961520
25ERBB31.72916268
26VRK11.70394552
27TEC1.69727161
28BTK1.69225727
29JAK31.66754018
30MAPK131.64474544
31TGFBR21.59206576
32MKNK11.58059350
33IRAK41.56831064
34BMPR21.55816320
35TNIK1.54247845
36FLT31.52346996
37INSRR1.44612030
38MKNK21.42552384
39PNCK1.41138319
40BMPR1B1.38363823
41CLK11.35355890
42STK101.32126732
43ZAK1.30526687
44EPHA31.29133913
45TBK11.29048304
46CSF1R1.28234023
47DYRK21.25842185
48NEK61.22311059
49PLK41.22299313
50FGFR21.16374442
51LYN1.13220490
52CSNK1G11.11711957
53CSNK1G21.09405500
54EIF2AK31.08725462
55NME11.08493471
56BUB11.07778323
57SYK1.07570611
58STK391.06879170
59CAMK1G1.06301181
60MATK1.05478929
61PIM11.02982010
62CCNB11.02766973
63TTK1.01940033
64ADRBK21.01027490
65FER1.00996449
66YES11.00990480
67CSNK1G31.00256432
68SGK20.99660863
69PAK30.99228622
70TYK20.96686366
71GRK70.95839540
72NEK90.95777569
73CDK80.95122271
74OXSR10.94539682
75ATR0.94359418
76STK38L0.93496348
77PKN10.90911343
78IRAK20.90790301
79PLK10.87673267
80CDK120.86963119
81DYRK30.86096970
82ZAP700.85973395
83RPS6KA60.85883051
84RPS6KA50.85524408
85STK40.84802896
86LCK0.84641130
87FGFR30.82043791
88AKT30.80483925
89CAMK1D0.80038718
90SRPK10.78761942
91MAP2K70.76398601
92PASK0.75862841
93CDK30.75603034
94IRAK10.74308446
95TIE10.74298723
96TNK20.73259367
97PLK30.72563795
98SGK30.70407887
99JAK10.69735925
100MINK10.67801330
101HCK0.67392406
102ATM0.67293515
103EIF2AK20.67031440
104EIF2AK10.66817027
105MAP3K60.65054403
106CSNK1A1L0.64053981
107DAPK10.63473647
108MAPK110.63286139
109DAPK20.62731610
110MAP3K100.62318995
111WEE10.62007651
112NEK10.59496180
113RPS6KC10.59388336
114RPS6KL10.59388336
115SIK20.59085863
116WNK10.58544444
117MST40.58077141
118PKN20.57611155
119MAPK70.57331898
120STK30.57055376
121BLK0.56091108
122CSNK1E0.55828630
123RPS6KB10.55581020
124TAOK30.54833248
125CDK50.54206630
126DYRK1A0.53377768
127AURKB0.52740340
128PIM20.52469309
129BRD40.52358024
130GRK10.51364454
131MAP3K120.51324025
132ITK0.49527530
133MAP2K40.49072776
134FGFR10.48632491
135KSR10.48124525
136PRKDC0.46734615
137STK160.45209817
138CHEK10.44225376
139PRKCE0.43345665
140TGFBR10.43205679
141PRKG10.42941443
142MAPKAPK20.42720055
143CSNK1D0.40270335
144GSK3B0.40240051
145PRKCZ0.40005174
146CDK10.39735835
147PLK20.39228451
148SIK30.39049845
149PIK3CA0.37313004
150JAK20.36823485
151TAF10.36652160
152CAMKK20.35929556
153NEK20.35422241
154CAMK40.35042524
155CDK20.34249423
156BCR0.34048027
157CDK70.33791047
158MAPK140.33446586
159BRSK20.33195487
160CDC42BPA0.33137179

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.58102946
2Allograft rejection_Homo sapiens_hsa053302.42935402
3Propanoate metabolism_Homo sapiens_hsa006402.41525608
4Butanoate metabolism_Homo sapiens_hsa006502.40418312
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34924394
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30130120
7Measles_Homo sapiens_hsa051622.27404947
8Leishmaniasis_Homo sapiens_hsa051402.18691152
9Fatty acid elongation_Homo sapiens_hsa000622.18156217
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.17187047
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13068410
12Primary immunodeficiency_Homo sapiens_hsa053402.12409985
13B cell receptor signaling pathway_Homo sapiens_hsa046622.08207707
14Protein export_Homo sapiens_hsa030602.07824180
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01928989
16Lysine degradation_Homo sapiens_hsa003101.98191228
17Nicotine addiction_Homo sapiens_hsa050331.92681755
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91328019
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.87644790
20Mismatch repair_Homo sapiens_hsa034301.83888602
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80798365
22Legionellosis_Homo sapiens_hsa051341.80448303
23DNA replication_Homo sapiens_hsa030301.79053213
24Non-homologous end-joining_Homo sapiens_hsa034501.76656836
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73018654
26Herpes simplex infection_Homo sapiens_hsa051681.70418202
27Influenza A_Homo sapiens_hsa051641.70183122
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.68218594
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68182841
30Osteoclast differentiation_Homo sapiens_hsa043801.68136592
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68105596
32Toxoplasmosis_Homo sapiens_hsa051451.68059572
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60780518
34Fatty acid metabolism_Homo sapiens_hsa012121.60493048
35Steroid biosynthesis_Homo sapiens_hsa001001.56833570
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.53914572
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51998535
38Hepatitis B_Homo sapiens_hsa051611.47920675
39Graft-versus-host disease_Homo sapiens_hsa053321.47857734
40Antigen processing and presentation_Homo sapiens_hsa046121.47742915
41Autoimmune thyroid disease_Homo sapiens_hsa053201.45086156
42Hematopoietic cell lineage_Homo sapiens_hsa046401.44935666
43Base excision repair_Homo sapiens_hsa034101.41874722
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41670512
45Pertussis_Homo sapiens_hsa051331.39133173
46beta-Alanine metabolism_Homo sapiens_hsa004101.37486533
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37142741
48Selenocompound metabolism_Homo sapiens_hsa004501.32498193
49T cell receptor signaling pathway_Homo sapiens_hsa046601.32336443
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32224191
51TNF signaling pathway_Homo sapiens_hsa046681.31706394
52Viral myocarditis_Homo sapiens_hsa054161.29259177
53Vitamin digestion and absorption_Homo sapiens_hsa049771.28626921
54Fatty acid degradation_Homo sapiens_hsa000711.28251858
55Systemic lupus erythematosus_Homo sapiens_hsa053221.26804918
56Platelet activation_Homo sapiens_hsa046111.26516202
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25860465
58Homologous recombination_Homo sapiens_hsa034401.19810144
59Chronic myeloid leukemia_Homo sapiens_hsa052201.19475472
60Type I diabetes mellitus_Homo sapiens_hsa049401.19147238
61Small cell lung cancer_Homo sapiens_hsa052221.18666494
62Cell cycle_Homo sapiens_hsa041101.16842374
63Epstein-Barr virus infection_Homo sapiens_hsa051691.12451089
64Tryptophan metabolism_Homo sapiens_hsa003801.12402065
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12208621
66Malaria_Homo sapiens_hsa051441.11816774
67Acute myeloid leukemia_Homo sapiens_hsa052211.11687113
68Colorectal cancer_Homo sapiens_hsa052101.10279083
69Viral carcinogenesis_Homo sapiens_hsa052031.09894918
70Other glycan degradation_Homo sapiens_hsa005111.09750034
71Pancreatic cancer_Homo sapiens_hsa052121.04194175
72Chemokine signaling pathway_Homo sapiens_hsa040621.03342997
73Oocyte meiosis_Homo sapiens_hsa041141.03341674
74Spliceosome_Homo sapiens_hsa030401.02693065
75Asthma_Homo sapiens_hsa053101.01711599
76Fanconi anemia pathway_Homo sapiens_hsa034601.01272622
77Taste transduction_Homo sapiens_hsa047420.98083745
78Shigellosis_Homo sapiens_hsa051310.97538572
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.97229494
80Apoptosis_Homo sapiens_hsa042100.95801256
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94686026
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93176251
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92691651
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92635883
85Tuberculosis_Homo sapiens_hsa051520.89411190
86Dorso-ventral axis formation_Homo sapiens_hsa043200.88324482
87Salmonella infection_Homo sapiens_hsa051320.87880755
88Insulin secretion_Homo sapiens_hsa049110.86998613
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86889438
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86517551
91Circadian rhythm_Homo sapiens_hsa047100.84517854
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82923827
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82769598
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81009218
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80970590
96Basal transcription factors_Homo sapiens_hsa030220.80736052
97African trypanosomiasis_Homo sapiens_hsa051430.80653098
98Non-small cell lung cancer_Homo sapiens_hsa052230.80531000
99RNA degradation_Homo sapiens_hsa030180.79318513
100HTLV-I infection_Homo sapiens_hsa051660.79229228
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77843281
102MicroRNAs in cancer_Homo sapiens_hsa052060.77210636
103Prolactin signaling pathway_Homo sapiens_hsa049170.76867241
104Axon guidance_Homo sapiens_hsa043600.76588854
105Purine metabolism_Homo sapiens_hsa002300.76548576
106Prostate cancer_Homo sapiens_hsa052150.75611129
107Phototransduction_Homo sapiens_hsa047440.75174719
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.71659765
109RNA polymerase_Homo sapiens_hsa030200.71561452
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70724566
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.70660048
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69353048
113Long-term depression_Homo sapiens_hsa047300.68844231
114p53 signaling pathway_Homo sapiens_hsa041150.68760312
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67069782
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66644702
117Hepatitis C_Homo sapiens_hsa051600.66566702
118Pyruvate metabolism_Homo sapiens_hsa006200.65098676
119Linoleic acid metabolism_Homo sapiens_hsa005910.64195919
120One carbon pool by folate_Homo sapiens_hsa006700.64139866
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63416740
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62075893
123Wnt signaling pathway_Homo sapiens_hsa043100.62003184
124Regulation of autophagy_Homo sapiens_hsa041400.61910160
125Pyrimidine metabolism_Homo sapiens_hsa002400.61694599
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.58775446
127TGF-beta signaling pathway_Homo sapiens_hsa043500.58436296
128Peroxisome_Homo sapiens_hsa041460.57977824
129Nucleotide excision repair_Homo sapiens_hsa034200.56900131
130Glutamatergic synapse_Homo sapiens_hsa047240.56837913
131Alcoholism_Homo sapiens_hsa050340.55977340
132Adherens junction_Homo sapiens_hsa045200.52986515
133Hippo signaling pathway_Homo sapiens_hsa043900.52752241
134Type II diabetes mellitus_Homo sapiens_hsa049300.51952525
135FoxO signaling pathway_Homo sapiens_hsa040680.51350714
136Staphylococcus aureus infection_Homo sapiens_hsa051500.50715076
137Dopaminergic synapse_Homo sapiens_hsa047280.50248395
138Endometrial cancer_Homo sapiens_hsa052130.49732552
139RNA transport_Homo sapiens_hsa030130.48868555
140mTOR signaling pathway_Homo sapiens_hsa041500.48702929
141mRNA surveillance pathway_Homo sapiens_hsa030150.48347567
142GABAergic synapse_Homo sapiens_hsa047270.48092611
143Hedgehog signaling pathway_Homo sapiens_hsa043400.47201694
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46612522
145Ovarian steroidogenesis_Homo sapiens_hsa049130.43870567
146Fatty acid biosynthesis_Homo sapiens_hsa000610.43746084
147Amoebiasis_Homo sapiens_hsa051460.42835895
148Glucagon signaling pathway_Homo sapiens_hsa049220.42756491
149Glioma_Homo sapiens_hsa052140.42157260
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42025834
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42011750
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41653001
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.41413080
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40844966
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40771926
156Thyroid hormone synthesis_Homo sapiens_hsa049180.40585824
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39138184
158Tight junction_Homo sapiens_hsa045300.39052250
159Insulin signaling pathway_Homo sapiens_hsa049100.38013566
160Retinol metabolism_Homo sapiens_hsa008300.37796995
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37546313
162AMPK signaling pathway_Homo sapiens_hsa041520.37421810
163Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37283624
164Pathways in cancer_Homo sapiens_hsa052000.36992196
165Rheumatoid arthritis_Homo sapiens_hsa053230.36938080
166Circadian entrainment_Homo sapiens_hsa047130.36725844
167Nitrogen metabolism_Homo sapiens_hsa009100.36681091
168Ether lipid metabolism_Homo sapiens_hsa005650.36042063
169ABC transporters_Homo sapiens_hsa020100.34847939
170HIF-1 signaling pathway_Homo sapiens_hsa040660.34730283
171Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34464142
172Morphine addiction_Homo sapiens_hsa050320.33217268
173Caffeine metabolism_Homo sapiens_hsa002320.30588115
174Amphetamine addiction_Homo sapiens_hsa050310.29768998

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