ZFP69B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.73888055
2somatic hypermutation of immunoglobulin genes (GO:0016446)4.71845356
3somatic diversification of immune receptors via somatic mutation (GO:0002566)4.71845356
4mitotic sister chromatid cohesion (GO:0007064)4.14310761
5presynaptic membrane assembly (GO:0097105)4.11496617
6DNA double-strand break processing (GO:0000729)4.06715394
7protein localization to kinetochore (GO:0034501)3.89618775
8positive regulation of action potential (GO:0045760)3.80218002
9tachykinin receptor signaling pathway (GO:0007217)3.75572895
10negative regulation of DNA recombination (GO:0045910)3.70389255
11regulation of helicase activity (GO:0051095)3.64443905
12pyrimidine nucleobase catabolic process (GO:0006208)3.45898449
13nuclear pore complex assembly (GO:0051292)3.45174054
14histone H2A acetylation (GO:0043968)3.38997130
15DNA topological change (GO:0006265)3.34551077
16protein localization to chromosome, centromeric region (GO:0071459)3.32872328
17protein localization to chromosome (GO:0034502)3.31772810
18nuclear pore organization (GO:0006999)3.25851392
19sequestering of actin monomers (GO:0042989)3.24652697
20presynaptic membrane organization (GO:0097090)3.22068121
21microtubule nucleation (GO:0007020)3.20763765
22regulation of meiosis I (GO:0060631)3.20260483
23L-serine metabolic process (GO:0006563)3.19933928
24regulation of DNA endoreduplication (GO:0032875)3.15484230
25sister chromatid segregation (GO:0000819)3.08410617
26forebrain neuron differentiation (GO:0021879)3.05429436
27postsynaptic membrane organization (GO:0001941)2.98843174
28microtubule anchoring (GO:0034453)2.97993856
29DNA ligation (GO:0006266)2.95676771
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93629551
31head development (GO:0060322)2.92402579
32non-recombinational repair (GO:0000726)2.91252531
33double-strand break repair via nonhomologous end joining (GO:0006303)2.91252531
34regulation of double-strand break repair via homologous recombination (GO:0010569)2.89384292
35microtubule depolymerization (GO:0007019)2.86931066
36regulation of RNA export from nucleus (GO:0046831)2.85617498
37neural tube formation (GO:0001841)2.83384524
38resolution of meiotic recombination intermediates (GO:0000712)2.83276102
39mitotic chromosome condensation (GO:0007076)2.79480151
40mitotic sister chromatid segregation (GO:0000070)2.79108433
41chromatin remodeling at centromere (GO:0031055)2.78868842
42negative regulation of mRNA processing (GO:0050686)2.78606519
43CENP-A containing nucleosome assembly (GO:0034080)2.77248337
44cerebral cortex radially oriented cell migration (GO:0021799)2.76769211
45DNA replication checkpoint (GO:0000076)2.76714245
46pore complex assembly (GO:0046931)2.75569874
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74344333
48positive regulation of RNA splicing (GO:0033120)2.73488645
49peptidyl-arginine omega-N-methylation (GO:0035247)2.73428760
50protein-cofactor linkage (GO:0018065)2.70724364
51postreplication repair (GO:0006301)2.69913838
52neuron fate determination (GO:0048664)2.68998522
53somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67693356
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67693356
55isotype switching (GO:0045190)2.67693356
56DNA damage response, detection of DNA damage (GO:0042769)2.67544542
57DNA synthesis involved in DNA repair (GO:0000731)2.66515997
58DNA integration (GO:0015074)2.65660013
59mitotic spindle organization (GO:0007052)2.65155038
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64758824
61DNA replication-dependent nucleosome organization (GO:0034723)2.64693569
62DNA replication-dependent nucleosome assembly (GO:0006335)2.64693569
63kinetochore organization (GO:0051383)2.63692936
64protein-DNA complex disassembly (GO:0032986)2.62896735
65nucleosome disassembly (GO:0006337)2.62896735
66mitotic metaphase plate congression (GO:0007080)2.62639186
67ATP-dependent chromatin remodeling (GO:0043044)2.61463673
68positive regulation of vascular permeability (GO:0043117)2.61265964
69mRNA splice site selection (GO:0006376)2.59230184
70mitotic spindle checkpoint (GO:0071174)2.58079325
71cytoplasmic mRNA processing body assembly (GO:0033962)2.57585574
72attachment of spindle microtubules to kinetochore (GO:0008608)2.56868942
73establishment of mitochondrion localization (GO:0051654)2.55843823
74peptidyl-arginine N-methylation (GO:0035246)2.55440638
75peptidyl-arginine methylation (GO:0018216)2.55440638
76negative regulation of chromosome segregation (GO:0051985)2.55079274
77nucleobase catabolic process (GO:0046113)2.53824939
78negative regulation of mitotic sister chromatid separation (GO:2000816)2.53473521
79negative regulation of sister chromatid segregation (GO:0033046)2.53473521
80negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53473521
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.53473521
82negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53473521
83central nervous system projection neuron axonogenesis (GO:0021952)2.53285179
84histone exchange (GO:0043486)2.52733966
85spindle checkpoint (GO:0031577)2.51323715
86centriole replication (GO:0007099)2.50565534
87spindle assembly checkpoint (GO:0071173)2.49602823
88cerebral cortex cell migration (GO:0021795)2.49577340
89somatic cell DNA recombination (GO:0016444)2.49404923
90somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.49404923
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48607840
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48607840
93mitotic spindle assembly checkpoint (GO:0007094)2.48135367
94regulation of mRNA splicing, via spliceosome (GO:0048024)2.48096060
95drinking behavior (GO:0042756)2.47546411
96spermatid nucleus differentiation (GO:0007289)2.47354216
97sister chromatid cohesion (GO:0007062)2.46902166
98metaphase plate congression (GO:0051310)2.46307283
99regulation of mitotic spindle checkpoint (GO:1903504)2.45905245
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45905245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.15607638
2EZH2_22144423_ChIP-Seq_EOC_Human3.24628436
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20391872
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04808556
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.03891715
6ZNF274_21170338_ChIP-Seq_K562_Hela2.98936549
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.65360149
8IRF1_19129219_ChIP-ChIP_H3396_Human2.58198728
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55098647
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.48849894
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47308928
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35014910
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33028827
14GBX2_23144817_ChIP-Seq_PC3_Human2.24734225
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20265283
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.19809523
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17153623
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14021959
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07906903
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.03182603
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96302690
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95414144
23IGF1R_20145208_ChIP-Seq_DFB_Human1.93254562
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92167147
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91518584
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90751878
27TAF15_26573619_Chip-Seq_HEK293_Human1.90491341
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89900055
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86367890
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81847794
31ELK1_19687146_ChIP-ChIP_HELA_Human1.80104730
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74519932
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.73799822
34EWS_26573619_Chip-Seq_HEK293_Human1.72026297
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69827338
36MYC_18940864_ChIP-ChIP_HL60_Human1.69484051
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.65074210
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62126633
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.60252303
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59060426
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.56720994
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.51495968
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51452317
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48058762
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.47944890
46VDR_22108803_ChIP-Seq_LS180_Human1.44920531
47GABP_19822575_ChIP-Seq_HepG2_Human1.44654734
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44494606
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44443373
50VDR_23849224_ChIP-Seq_CD4+_Human1.43447117
51FUS_26573619_Chip-Seq_HEK293_Human1.41733159
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39012017
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38498114
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.34974872
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34164311
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33172773
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32507291
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.30230157
59DCP1A_22483619_ChIP-Seq_HELA_Human1.30020010
60SOX9_26525672_Chip-Seq_HEART_Mouse1.28620641
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27488205
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27164567
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26480809
64CBP_20019798_ChIP-Seq_JUKART_Human1.26480809
65FOXP3_21729870_ChIP-Seq_TREG_Human1.22417446
66P300_19829295_ChIP-Seq_ESCs_Human1.20720533
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19045325
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19020441
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.17912308
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14709930
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14316537
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14173849
73RNF2_27304074_Chip-Seq_NSC_Mouse1.13057355
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11582031
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09349570
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08512253
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08439828
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08361580
79TTF2_22483619_ChIP-Seq_HELA_Human1.06208563
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04828363
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04699590
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04395833
83SMAD4_21799915_ChIP-Seq_A2780_Human1.02578333
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99532189
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98822122
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97577161
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96505209
88CIITA_25753668_ChIP-Seq_RAJI_Human0.95966346
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95305310
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94522954
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93352482
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92412938
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90381996
94STAT3_23295773_ChIP-Seq_U87_Human0.90022233
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88930249
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88094303
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87466601
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87249611
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87181968
100XRN2_22483619_ChIP-Seq_HELA_Human0.86242690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.93835863
2MP0008058_abnormal_DNA_repair3.26717510
3MP0003880_abnormal_central_pattern2.78073148
4MP0010094_abnormal_chromosome_stability2.72822173
5MP0003890_abnormal_embryonic-extraembry2.38890456
6MP0003122_maternal_imprinting2.27602531
7MP0003111_abnormal_nucleus_morphology2.27475069
8MP0002736_abnormal_nociception_after2.15508455
9MP0004859_abnormal_synaptic_plasticity2.15060739
10MP0005394_taste/olfaction_phenotype2.14447754
11MP0005499_abnormal_olfactory_system2.14447754
12MP0003693_abnormal_embryo_hatching2.12808211
13MP0008789_abnormal_olfactory_epithelium2.03668563
14MP0004270_analgesia1.99589423
15MP0002102_abnormal_ear_morphology1.99491273
16MP0000778_abnormal_nervous_system1.96531261
17MP0008932_abnormal_embryonic_tissue1.94098533
18MP0003136_yellow_coat_color1.93574670
19MP0003077_abnormal_cell_cycle1.88956374
20MP0003121_genomic_imprinting1.88506111
21MP0001188_hyperpigmentation1.86974183
22MP0002735_abnormal_chemical_nociception1.83513292
23MP0003718_maternal_effect1.77654440
24MP0008877_abnormal_DNA_methylation1.76628750
25MP0002822_catalepsy1.75688596
26MP0001299_abnormal_eye_distance/1.73402657
27MP0004957_abnormal_blastocyst_morpholog1.69365371
28MP0004811_abnormal_neuron_physiology1.65605394
29MP0002751_abnormal_autonomic_nervous1.65541030
30MP0001968_abnormal_touch/_nociception1.60480337
31MP0002233_abnormal_nose_morphology1.54492371
32MP0003635_abnormal_synaptic_transmissio1.50154821
33MP0002653_abnormal_ependyma_morphology1.49556907
34MP0000049_abnormal_middle_ear1.46829490
35MP0003755_abnormal_palate_morphology1.46703297
36MP0003861_abnormal_nervous_system1.46215390
37MP0008007_abnormal_cellular_replicative1.45709254
38MP0002734_abnormal_mechanical_nocicepti1.42919091
39MP0005187_abnormal_penis_morphology1.42912238
40MP0006276_abnormal_autonomic_nervous1.38126420
41MP0006035_abnormal_mitochondrial_morpho1.31176625
42MP0001984_abnormal_olfaction1.30373712
43MP0003937_abnormal_limbs/digits/tail_de1.28279302
44MP0006292_abnormal_olfactory_placode1.26200644
45MP0000631_abnormal_neuroendocrine_gland1.23915832
46MP0004133_heterotaxia1.21058271
47MP0009697_abnormal_copulation1.19493334
48MP0002184_abnormal_innervation1.19354635
49MP0004885_abnormal_endolymph1.18809497
50MP0004197_abnormal_fetal_growth/weight/1.18594184
51MP0000647_abnormal_sebaceous_gland1.16648090
52MP0002234_abnormal_pharynx_morphology1.16203472
53MP0002063_abnormal_learning/memory/cond1.15281992
54MP0000955_abnormal_spinal_cord1.13068963
55MP0005645_abnormal_hypothalamus_physiol1.12934869
56MP0004142_abnormal_muscle_tone1.12344627
57MP0000569_abnormal_digit_pigmentation1.09767188
58MP0002084_abnormal_developmental_patter1.09733151
59MP0001730_embryonic_growth_arrest1.09260336
60MP0005423_abnormal_somatic_nervous1.09234643
61MP0003221_abnormal_cardiomyocyte_apopto1.09035615
62MP0002557_abnormal_social/conspecific_i1.08759996
63MP0002152_abnormal_brain_morphology1.08733681
64MP0003119_abnormal_digestive_system1.08524495
65MP0009703_decreased_birth_body1.06304703
66MP0001177_atelectasis1.06066988
67MP0001929_abnormal_gametogenesis1.05685594
68MP0003787_abnormal_imprinting1.05174387
69MP0004742_abnormal_vestibular_system1.05168865
70MP0002882_abnormal_neuron_morphology1.04727136
71MP0002277_abnormal_respiratory_mucosa1.04546828
72MP0003567_abnormal_fetal_cardiomyocyte1.03868945
73MP0003786_premature_aging1.03620530
74MP0001270_distended_abdomen1.02372936
75MP0000350_abnormal_cell_proliferation1.02282365
76MP0002697_abnormal_eye_size1.02176574
77MP0002572_abnormal_emotion/affect_behav1.01663197
78MP0005380_embryogenesis_phenotype1.01467513
79MP0001672_abnormal_embryogenesis/_devel1.01467513
80MP0001286_abnormal_eye_development1.00098128
81MP0002938_white_spotting0.99652258
82MP0003698_abnormal_male_reproductive0.98569513
83MP0002085_abnormal_embryonic_tissue0.98549052
84MP0002210_abnormal_sex_determination0.97782190
85MP0002081_perinatal_lethality0.96074522
86MP0003385_abnormal_body_wall0.95642109
87MP0008995_early_reproductive_senescence0.95417487
88MP0002272_abnormal_nervous_system0.93764393
89MP0009046_muscle_twitch0.91032114
90MP0009745_abnormal_behavioral_response0.90976512
91MP0008057_abnormal_DNA_replication0.88399590
92MP0009672_abnormal_birth_weight0.86931943
93MP0002067_abnormal_sensory_capabilities0.86145938
94MP0002177_abnormal_outer_ear0.85800345
95MP0002752_abnormal_somatic_nervous0.85318031
96MP0000358_abnormal_cell_content/0.83618092
97MP0003935_abnormal_craniofacial_develop0.83542118
98MP0004147_increased_porphyrin_level0.82243189
99MP0001145_abnormal_male_reproductive0.81984551
100MP0008770_decreased_survivor_rate0.81872751

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.26460439
2Medulloblastoma (HP:0002885)4.20149289
3Cortical dysplasia (HP:0002539)3.80880044
4Volvulus (HP:0002580)3.79290778
5Ependymoma (HP:0002888)3.42438992
6Neoplasm of the oral cavity (HP:0100649)2.94546077
7Lissencephaly (HP:0001339)2.92488353
8Atonic seizures (HP:0010819)2.89993316
9Nephrogenic diabetes insipidus (HP:0009806)2.86683744
10Retinal dysplasia (HP:0007973)2.82780130
11Glioma (HP:0009733)2.73843975
12Astrocytoma (HP:0009592)2.73618432
13Abnormality of the astrocytes (HP:0100707)2.73618432
14Aplasia/Hypoplasia of the sternum (HP:0006714)2.68613790
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68456066
16Shoulder girdle muscle weakness (HP:0003547)2.49775136
17Chromsome breakage (HP:0040012)2.49373597
18Agnosia (HP:0010524)2.46765137
19Oligodactyly (hands) (HP:0001180)2.43454718
20Gait imbalance (HP:0002141)2.42866347
21Rhabdomyosarcoma (HP:0002859)2.38512626
22Increased nuchal translucency (HP:0010880)2.36948131
23Thyroid-stimulating hormone excess (HP:0002925)2.36170716
24High anterior hairline (HP:0009890)2.28941685
25Long clavicles (HP:0000890)2.28553056
26Nephroblastoma (Wilms tumor) (HP:0002667)2.27853613
27Abnormality of chromosome stability (HP:0003220)2.27455554
28Meckel diverticulum (HP:0002245)2.25157203
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.23333283
30Abnormality of the ileum (HP:0001549)2.23282763
31Abnormality of the hip-girdle musculature (HP:0001445)2.20994111
32Abnormality of the musculature of the pelvis (HP:0001469)2.20994111
33Hip dysplasia (HP:0001385)2.18663820
34Embryonal renal neoplasm (HP:0011794)2.15942280
35Drooling (HP:0002307)2.13654938
36Congenital primary aphakia (HP:0007707)2.13576447
37Hepatoblastoma (HP:0002884)2.11160043
38Abnormal lung lobation (HP:0002101)2.08906809
39Oligodactyly (HP:0012165)2.07595873
40Intestinal atresia (HP:0011100)2.06408447
41Supernumerary spleens (HP:0009799)2.04791165
42Basal cell carcinoma (HP:0002671)2.02027877
43Abnormality of the lower motor neuron (HP:0002366)1.99321898
44Fibular hypoplasia (HP:0003038)1.98027909
45Cerebellar dysplasia (HP:0007033)1.96608886
46Duodenal stenosis (HP:0100867)1.96514771
47Small intestinal stenosis (HP:0012848)1.96514771
48Colon cancer (HP:0003003)1.95654999
49Pelvic girdle muscle weakness (HP:0003749)1.94643892
50Amyotrophic lateral sclerosis (HP:0007354)1.93814007
51Abnormality of the preputium (HP:0100587)1.93413735
52Abnormal hair whorl (HP:0010721)1.91358462
53Birth length less than 3rd percentile (HP:0003561)1.90910087
54Neoplasm of striated muscle (HP:0009728)1.90764933
55Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89205936
56Excessive salivation (HP:0003781)1.89025480
57Sloping forehead (HP:0000340)1.87663511
58Small hand (HP:0200055)1.86907736
59Neoplasm of the small intestine (HP:0100833)1.85116570
60Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84629981
61Medial flaring of the eyebrow (HP:0010747)1.84491451
62Short 4th metacarpal (HP:0010044)1.84420203
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84420203
64Focal motor seizures (HP:0011153)1.82904159
65Astigmatism (HP:0000483)1.80584208
66Gastroesophageal reflux (HP:0002020)1.79346501
67Broad alveolar ridges (HP:0000187)1.76773034
68Postnatal microcephaly (HP:0005484)1.76656313
69Split foot (HP:0001839)1.75444914
70Proximal placement of thumb (HP:0009623)1.75045330
71Biliary tract neoplasm (HP:0100574)1.74648691
72Pachygyria (HP:0001302)1.73569803
73Conjugated hyperbilirubinemia (HP:0002908)1.72871541
74Hypsarrhythmia (HP:0002521)1.71263156
75Abnormality of the duodenum (HP:0002246)1.70454837
76Spastic diplegia (HP:0001264)1.68853421
77Morphological abnormality of the inner ear (HP:0011390)1.67387194
78Broad foot (HP:0001769)1.67303551
79Specific learning disability (HP:0001328)1.66366921
80Urinary urgency (HP:0000012)1.65091463
81Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64890057
82Hypoplasia of the brainstem (HP:0002365)1.64890057
83Failure to thrive in infancy (HP:0001531)1.63380916
84Poor coordination (HP:0002370)1.62501211
85Abnormality of the carotid arteries (HP:0005344)1.61912875
86Neoplasm of the colon (HP:0100273)1.60474695
87Papillary thyroid carcinoma (HP:0002895)1.60313153
88Micropenis (HP:0000054)1.58849711
89Type II lissencephaly (HP:0007260)1.58571167
90Abnormality of the antihelix (HP:0009738)1.57836603
91Patellar aplasia (HP:0006443)1.57674366
92Neuroblastic tumors (HP:0004376)1.57652128
93Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.57652128
94Neuroblastoma (HP:0003006)1.57652128
95Primitive neuroectodermal tumor (HP:0030065)1.57652128
96Abnormality of the labia (HP:0000058)1.57334636
97Upper limb muscle weakness (HP:0003484)1.56886340
98Hemivertebrae (HP:0002937)1.56872912
99Overlapping toe (HP:0001845)1.56677970
100EEG with generalized epileptiform discharges (HP:0011198)1.56481656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.03623427
2MARK13.38883841
3BCR3.32515131
4MAP2K73.09839182
5TSSK62.74293342
6MAPK132.71185342
7BUB12.56483246
8SRPK12.56152898
9PNCK2.29485682
10WNK32.20750286
11TRIM282.19791640
12TTK2.14697165
13LATS12.12752004
14BRD42.11319158
15MAP4K22.04102150
16CDC71.97247475
17EPHA41.96257109
18CAMK1G1.87991658
19ERBB31.80729176
20NUAK11.75272681
21CAMK1D1.70926172
22RPS6KA41.65840726
23NEK11.58295543
24CAMKK21.56376080
25CDK31.42662401
26CDK121.34596491
27BRSK21.34422491
28CASK1.31931910
29DYRK21.28036301
30MAP2K41.26597819
31PLK31.25314384
32MKNK21.24299831
33CSNK1G11.21373750
34ZAK1.20963029
35CSNK1G21.16958171
36CSNK1A1L1.12728182
37NTRK21.11574133
38PLK11.08960871
39KSR11.08908761
40WEE11.07405429
41STK38L1.07304929
42CSNK1G31.05835382
43MKNK11.05022151
44PLK41.03587873
45CLK11.02338423
46ATR1.01190989
47DYRK30.99925327
48VRK10.93840520
49ATM0.88262102
50AKT30.87202728
51CCNB10.86237715
52AURKB0.86025779
53STK160.85841534
54EPHA30.84406262
55CAMK40.77055936
56PAK40.74551771
57ERBB40.74292296
58CHEK20.71273842
59SIK20.67799751
60CHEK10.66339734
61PLK20.65688627
62CDK140.65508791
63CDK10.64562322
64SCYL20.64453647
65CDK180.63575582
66UHMK10.62549872
67BMPR1B0.62276749
68EIF2AK30.62043601
69CDK20.61871123
70MAP3K60.61028993
71CDK150.58772770
72MAP3K50.57711346
73RAF10.57645510
74SIK30.57496282
75PRKCG0.57228262
76WNK10.56679674
77STK30.55118746
78MINK10.54744412
79AURKA0.54622888
80CSNK1E0.54277708
81CDK11A0.53517040
82PKN10.53465321
83STK40.47130843
84EIF2AK10.46821663
85BRSK10.45033726
86PAK30.44391778
87CDK80.44076708
88CAMK2B0.41070385
89PRKDC0.40612488
90CSNK1D0.40395393
91GSK3B0.39384325
92PRKCI0.38836884
93MAPK140.38836733
94BRAF0.37527510
95MAPK90.37265684
96FGFR10.36721817
97YES10.36575715
98TYRO30.36220269
99PRKCE0.35800547
100BCKDK0.35307201

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.20681114
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.11422167
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04700380
4Fanconi anemia pathway_Homo sapiens_hsa034602.55784266
5Base excision repair_Homo sapiens_hsa034102.54582862
6Steroid biosynthesis_Homo sapiens_hsa001002.54036930
7Basal transcription factors_Homo sapiens_hsa030222.46403004
8Nicotine addiction_Homo sapiens_hsa050332.44187285
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.43157287
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36018696
11DNA replication_Homo sapiens_hsa030302.35579195
12RNA transport_Homo sapiens_hsa030132.30769389
13Spliceosome_Homo sapiens_hsa030402.27403476
14Cell cycle_Homo sapiens_hsa041102.20182318
15Non-homologous end-joining_Homo sapiens_hsa034502.12596927
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10226281
17mRNA surveillance pathway_Homo sapiens_hsa030152.05681745
18Selenocompound metabolism_Homo sapiens_hsa004501.97612099
19Nucleotide excision repair_Homo sapiens_hsa034201.89712966
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68916474
21Protein export_Homo sapiens_hsa030601.68821730
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59637720
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56091621
24Homologous recombination_Homo sapiens_hsa034401.53834779
25Taste transduction_Homo sapiens_hsa047421.48910912
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44739087
27One carbon pool by folate_Homo sapiens_hsa006701.44266037
28RNA degradation_Homo sapiens_hsa030181.42757818
29Oocyte meiosis_Homo sapiens_hsa041141.39132223
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29121772
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28259906
32Axon guidance_Homo sapiens_hsa043601.22857310
33Proteasome_Homo sapiens_hsa030501.22431000
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19667240
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17366719
36GABAergic synapse_Homo sapiens_hsa047271.16297514
37Phototransduction_Homo sapiens_hsa047441.13687141
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13136903
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.08643084
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01635492
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97950195
42Pyrimidine metabolism_Homo sapiens_hsa002400.96880886
43Alcoholism_Homo sapiens_hsa050340.95164152
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94641297
45Butanoate metabolism_Homo sapiens_hsa006500.94292400
46RNA polymerase_Homo sapiens_hsa030200.94219923
47Colorectal cancer_Homo sapiens_hsa052100.93908923
48Hippo signaling pathway_Homo sapiens_hsa043900.91028557
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86646055
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.85021048
51MicroRNAs in cancer_Homo sapiens_hsa052060.83015551
52Propanoate metabolism_Homo sapiens_hsa006400.80697871
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79288455
54Dopaminergic synapse_Homo sapiens_hsa047280.79211690
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76952804
56Vitamin B6 metabolism_Homo sapiens_hsa007500.76264919
57Purine metabolism_Homo sapiens_hsa002300.73816342
58Glutamatergic synapse_Homo sapiens_hsa047240.72968798
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71819627
60Wnt signaling pathway_Homo sapiens_hsa043100.68452586
61ErbB signaling pathway_Homo sapiens_hsa040120.67413079
62Morphine addiction_Homo sapiens_hsa050320.65226975
63Circadian rhythm_Homo sapiens_hsa047100.64255680
64Biosynthesis of amino acids_Homo sapiens_hsa012300.62184617
65N-Glycan biosynthesis_Homo sapiens_hsa005100.61674789
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58465915
67p53 signaling pathway_Homo sapiens_hsa041150.58013572
68Cocaine addiction_Homo sapiens_hsa050300.54642998
69TGF-beta signaling pathway_Homo sapiens_hsa043500.53970020
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53432316
71Viral carcinogenesis_Homo sapiens_hsa052030.52977304
72Long-term depression_Homo sapiens_hsa047300.51477216
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49617827
74Hedgehog signaling pathway_Homo sapiens_hsa043400.47922948
75Fatty acid biosynthesis_Homo sapiens_hsa000610.46882429
76Circadian entrainment_Homo sapiens_hsa047130.46059438
77Amphetamine addiction_Homo sapiens_hsa050310.46049276
78Gap junction_Homo sapiens_hsa045400.45483090
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44677286
80Synaptic vesicle cycle_Homo sapiens_hsa047210.44144304
81Shigellosis_Homo sapiens_hsa051310.41981206
82Type II diabetes mellitus_Homo sapiens_hsa049300.41267020
83Inositol phosphate metabolism_Homo sapiens_hsa005620.40417679
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35358149
85Melanoma_Homo sapiens_hsa052180.33923479
86Olfactory transduction_Homo sapiens_hsa047400.33037993
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32847630
88Huntingtons disease_Homo sapiens_hsa050160.31724020
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31366691
90Basal cell carcinoma_Homo sapiens_hsa052170.31124193
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30750654
92AMPK signaling pathway_Homo sapiens_hsa041520.30518051
93Lysine degradation_Homo sapiens_hsa003100.28967059
94Pyruvate metabolism_Homo sapiens_hsa006200.26305182
95Cholinergic synapse_Homo sapiens_hsa047250.25520944
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.24235988
97Renal cell carcinoma_Homo sapiens_hsa052110.23950439
98Adherens junction_Homo sapiens_hsa045200.23553164
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23533705
100FoxO signaling pathway_Homo sapiens_hsa040680.22166977

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