ZFP91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.47777631
2nuclear pore organization (GO:0006999)4.36808614
3cytoplasmic mRNA processing body assembly (GO:0033962)4.19528546
4protein localization to endosome (GO:0036010)4.11624050
5mitotic chromosome condensation (GO:0007076)3.92152123
6Golgi transport vesicle coating (GO:0048200)3.89265003
7COPI coating of Golgi vesicle (GO:0048205)3.89265003
8pore complex assembly (GO:0046931)3.87897307
9positive regulation of fatty acid beta-oxidation (GO:0032000)3.81825199
10regulation of early endosome to late endosome transport (GO:2000641)3.71641548
11carnitine shuttle (GO:0006853)3.71326284
12embryonic process involved in female pregnancy (GO:0060136)3.67605671
13fatty acid transmembrane transport (GO:1902001)3.67443736
14positive regulation of histone deacetylation (GO:0031065)3.56343720
15regulation of histone H3-K27 methylation (GO:0061085)3.48416869
16regulation of sequestering of triglyceride (GO:0010889)3.46322489
17regulation of fatty acid beta-oxidation (GO:0031998)3.42796086
18peptidyl-lysine dimethylation (GO:0018027)3.38757655
19plasma membrane repair (GO:0001778)3.37611375
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.37177852
21regulation of NFAT protein import into nucleus (GO:0051532)3.33287595
22positive regulation of fatty acid oxidation (GO:0046321)3.28419353
23carnitine transmembrane transport (GO:1902603)3.26240485
24skin morphogenesis (GO:0043589)3.26008873
25alpha-linolenic acid metabolic process (GO:0036109)3.23732844
26hemidesmosome assembly (GO:0031581)3.20537961
27amino-acid betaine transport (GO:0015838)3.11629579
28carnitine transport (GO:0015879)3.11629579
29negative regulation of erythrocyte differentiation (GO:0045647)3.10373550
30desmosome organization (GO:0002934)3.09305994
31insulin-like growth factor receptor signaling pathway (GO:0048009)3.04876826
32cell adhesion mediated by integrin (GO:0033627)3.01653665
33regulation of fatty acid oxidation (GO:0046320)2.93394688
34COPII vesicle coating (GO:0048208)2.93039802
35negative regulation of fatty acid transport (GO:2000192)2.91179511
36activation of Rac GTPase activity (GO:0032863)2.90104037
37protein localization to microtubule (GO:0035372)2.89999766
38NLS-bearing protein import into nucleus (GO:0006607)2.89153970
39corticosteroid receptor signaling pathway (GO:0031958)2.88185235
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.87397354
41negative regulation of anoikis (GO:2000811)2.84598769
42lysine metabolic process (GO:0006553)2.83917998
43lysine catabolic process (GO:0006554)2.83917998
44establishment of protein localization to Golgi (GO:0072600)2.82732385
45DNA unwinding involved in DNA replication (GO:0006268)2.81722195
46growth hormone receptor signaling pathway (GO:0060396)2.81615563
47embryonic retina morphogenesis in camera-type eye (GO:0060059)2.78331495
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.76403070
49mitotic sister chromatid cohesion (GO:0007064)2.76118420
50protein targeting to Golgi (GO:0000042)2.75417302
51mammary gland epithelial cell proliferation (GO:0033598)2.74502988
52SMAD protein complex assembly (GO:0007183)2.74451459
53low-density lipoprotein particle clearance (GO:0034383)2.74164759
54dicarboxylic acid biosynthetic process (GO:0043650)2.73303357
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72190694
56vesicle coating (GO:0006901)2.71510324
57positive regulation of lipid catabolic process (GO:0050996)2.71320305
58regulation of clathrin-mediated endocytosis (GO:2000369)2.71126572
59intracellular lipid transport (GO:0032365)2.70393493
60iron ion import (GO:0097286)2.68212144
61regulation of mitotic spindle organization (GO:0060236)2.63920314
62negative regulation of DNA repair (GO:0045738)2.63729682
63positive regulation of glycogen biosynthetic process (GO:0045725)2.62919831
64negative regulation of cell size (GO:0045792)2.62048740
65RNA stabilization (GO:0043489)2.60681824
66mRNA stabilization (GO:0048255)2.60681824
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59989733
68cortical actin cytoskeleton organization (GO:0030866)2.59737482
69regulation of cholesterol storage (GO:0010885)2.59056846
70regulation of anoikis (GO:2000209)2.57952595
71barbed-end actin filament capping (GO:0051016)2.56933616
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54529728
73positive regulation of cellular response to insulin stimulus (GO:1900078)2.54060787
74positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.53983041
75membrane raft organization (GO:0031579)2.52948960
76epithelial cell-cell adhesion (GO:0090136)2.51474163
77peptidyl-threonine modification (GO:0018210)2.50229999
78negative regulation of heart growth (GO:0061117)2.49502941
79negative regulation of cardiac muscle tissue growth (GO:0055022)2.49502941
80negative regulation of protein localization to plasma membrane (GO:1903077)2.48543024
81regulation of cholesterol homeostasis (GO:2000188)2.47025946
822-oxoglutarate metabolic process (GO:0006103)2.45574480
83neutral lipid catabolic process (GO:0046461)2.44912132
84acylglycerol catabolic process (GO:0046464)2.44912132
85activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44615613
86response to laminar fluid shear stress (GO:0034616)2.44376782
87protein export from nucleus (GO:0006611)2.44327854
88negative regulation of lipid transport (GO:0032369)2.42566297
89stress fiber assembly (GO:0043149)2.41924088
90peptidyl-threonine phosphorylation (GO:0018107)2.39943407
91regulation of nucleobase-containing compound transport (GO:0032239)2.38978555
92cellular protein complex localization (GO:0034629)2.38938116
93positive regulation of nuclease activity (GO:0032075)2.38466068
94triglyceride catabolic process (GO:0019433)2.38010000
95regulation of triglyceride catabolic process (GO:0010896)2.37880262
96cellular response to growth hormone stimulus (GO:0071378)2.37602110
97positive regulation of glycolytic process (GO:0045821)2.36781980
98phospholipid homeostasis (GO:0055091)2.36555334
99establishment of nucleus localization (GO:0040023)2.35796666
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.34908243
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34511401
102cellular response to osmotic stress (GO:0071470)2.34188650
103sodium ion export (GO:0071436)2.34109615
104regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.33960465
105regulation of RNA export from nucleus (GO:0046831)2.32784683
106positive regulation of glycogen metabolic process (GO:0070875)2.31682268
107cytoskeleton-dependent cytokinesis (GO:0061640)2.31618629
108endoplasmic reticulum unfolded protein response (GO:0030968)2.31343529
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31190018
110ER-nucleus signaling pathway (GO:0006984)2.30614476
111chromosome condensation (GO:0030261)2.29795645
112response to epidermal growth factor (GO:0070849)2.29722455
113fatty acid homeostasis (GO:0055089)2.29718309
114monoubiquitinated protein deubiquitination (GO:0035520)2.29285094
115coronary vasculature morphogenesis (GO:0060977)2.28194774
116pinocytosis (GO:0006907)2.27941059
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27274798
118positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.26943562
119macroautophagy (GO:0016236)2.26812014
120quaternary ammonium group transport (GO:0015697)2.26218807
121negative regulation of fibroblast apoptotic process (GO:2000270)2.25887233
122hypotonic response (GO:0006971)2.24438095
123adherens junction assembly (GO:0034333)2.23037480
124sister chromatid segregation (GO:0000819)2.22528153
125potassium ion import (GO:0010107)2.20713624
126embryonic camera-type eye morphogenesis (GO:0048596)2.20567550
127urea metabolic process (GO:0019627)2.20558636
128urea cycle (GO:0000050)2.20558636
129embryonic eye morphogenesis (GO:0048048)2.20352437
130positive regulation of protein export from nucleus (GO:0046827)2.20333005
131regulation of transforming growth factor beta2 production (GO:0032909)2.20210612
132regulation of p38MAPK cascade (GO:1900744)2.20042114
133dosage compensation (GO:0007549)2.20037714
134aspartate family amino acid catabolic process (GO:0009068)2.19967877
135positive regulation of lipid storage (GO:0010884)2.19560551
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19498543
137membrane protein ectodomain proteolysis (GO:0006509)2.19226386
138regulation of protein localization to plasma membrane (GO:1903076)2.18858916
139cellular response to epidermal growth factor stimulus (GO:0071364)2.18790727
140cortical cytoskeleton organization (GO:0030865)2.18554782
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.17769974
142negative regulation of cell killing (GO:0031342)2.17028360
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.17028360
144positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16673083
145positive regulation of fatty acid metabolic process (GO:0045923)2.16354370
146regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.16346133
147focal adhesion assembly (GO:0048041)2.16016724
148cell-substrate adherens junction assembly (GO:0007045)2.16016724
149regulation of Rac protein signal transduction (GO:0035020)2.15977688
150regulation of transforming growth factor beta1 production (GO:0032908)2.15899753
151cellular response to unfolded protein (GO:0034620)2.14360474
152protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.13542645
153regulation of protein export from nucleus (GO:0046825)2.13511936
154regulation of nuclease activity (GO:0032069)2.13082342
155regulation of ARF protein signal transduction (GO:0032012)2.12589049
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12550426
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.12477821
158histone H3-K36 demethylation (GO:0070544)2.12156367
159cellular potassium ion homeostasis (GO:0030007)2.11689471
160cysteine metabolic process (GO:0006534)2.11131375
161epoxygenase P450 pathway (GO:0019373)2.10831404
162histone H3-K9 demethylation (GO:0033169)2.10620061
163definitive hemopoiesis (GO:0060216)2.10584084
164cardiac myofibril assembly (GO:0055003)2.10322020
165valine metabolic process (GO:0006573)2.10217359
166positive regulation of myotube differentiation (GO:0010831)2.10159533
167glucocorticoid receptor signaling pathway (GO:0042921)2.09801787
168positive regulation of protein import into nucleus, translocation (GO:0033160)2.09703298
169mitotic cytokinesis (GO:0000281)2.09657781
170activation of protein kinase A activity (GO:0034199)2.08676965
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.08595859
172cell-substrate junction assembly (GO:0007044)2.08519458
173cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.08479593
174endoplasmic reticulum organization (GO:0007029)2.07152401
175hippo signaling (GO:0035329)2.05729102
176fatty acid beta-oxidation (GO:0006635)2.05178732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.23654636
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25010225
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04059152
4AR_21909140_ChIP-Seq_LNCAP_Human2.62647013
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.54510607
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.49746159
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45697657
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39503084
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33846464
10ZNF263_19887448_ChIP-Seq_K562_Human2.30575523
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27650470
12CLOCK_20551151_ChIP-Seq_293T_Human2.13457251
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11686062
14GATA1_22025678_ChIP-Seq_K562_Human2.10323960
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08922673
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08417199
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05143103
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95389716
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92187209
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92026050
21* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92026050
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89345512
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.85217399
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81666519
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81109959
26KDM2B_26808549_Chip-Seq_DND41_Human1.74826039
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71587704
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.71162977
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70699128
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.69130711
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.67848897
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67015357
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.65899392
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.64804115
35TCF7_22412390_ChIP-Seq_EML_Mouse1.60458785
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.57974478
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56396566
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55150085
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53744576
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50004849
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.49903385
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.49508349
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48633685
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47579676
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47423490
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.46618729
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.46618729
48KDM2B_26808549_Chip-Seq_K562_Human1.46396766
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43470238
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42163650
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41141083
52VDR_21846776_ChIP-Seq_THP-1_Human1.40252492
53BRD4_25478319_ChIP-Seq_HGPS_Human1.39246265
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.37269655
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36738607
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35946493
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35558003
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.35465330
59TP53_16413492_ChIP-PET_HCT116_Human1.35202908
60CHD1_26751641_Chip-Seq_LNCaP_Human1.34903751
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34323523
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32825285
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32648050
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32540831
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31779463
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.31133965
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30746636
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30515849
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28714941
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28246292
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27232165
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.26248045
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25891259
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25415733
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.25153577
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25108603
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.24565168
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24385831
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23593208
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23187003
81* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21037055
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18045596
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18041860
84GATA1_19941826_ChIP-Seq_K562_Human1.17359075
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17266125
86DROSHA_22980978_ChIP-Seq_HELA_Human1.16971211
87AHR_22903824_ChIP-Seq_MCF-7_Human1.16188633
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15642596
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14998038
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14373021
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13620603
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13394229
93* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12597340
94* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12171035
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10348811
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09269379
97VDR_24763502_ChIP-Seq_THP-1_Human1.06511026
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06471041
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06252450
100* TFEB_21752829_ChIP-Seq_HELA_Human1.06217770
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05789462
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05783980
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.05740915
104MYC_22102868_ChIP-Seq_BL_Human1.05710912
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.04889557
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03550808
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03511085
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02363887
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01923662
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01920710
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01744439
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.01388460
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00815061
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00536059
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99942107
116RARB_27405468_Chip-Seq_BRAIN_Mouse0.99010936
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98368276
118GATA6_25053715_ChIP-Seq_YYC3_Human0.97405017
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97336144
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97291130
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.97220500
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96955683
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.96899715
124* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96682822
125RXR_22108803_ChIP-Seq_LS180_Human0.96446988
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96283598
127CREB1_26743006_Chip-Seq_LNCaP_Human0.96180689
128* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96032899
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95544474
130GATA2_19941826_ChIP-Seq_K562_Human0.95089829
131* RUNX1_22412390_ChIP-Seq_EML_Mouse0.94528699
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93251200
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93138969
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92741808
135ATF3_27146783_Chip-Seq_COLON_Human0.92362244
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.91571306
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91506816
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91391998
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90469921
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89755725
141ZNF274_21170338_ChIP-Seq_K562_Hela0.89267907
142BCAT_22108803_ChIP-Seq_LS180_Human0.88595034
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88017528
144PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87977929
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87348717
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85337596
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.84391938
148RACK7_27058665_Chip-Seq_MCF-7_Human0.84084507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.03379966
2MP0010234_abnormal_vibrissa_follicle3.51368932
3MP0004185_abnormal_adipocyte_glucose3.36740317
4MP0004130_abnormal_muscle_cell3.33702872
5MP0003300_gastrointestinal_ulcer3.12861470
6MP0002139_abnormal_hepatobiliary_system2.87001833
7MP0005666_abnormal_adipose_tissue2.83360383
8MP0005360_urolithiasis2.57116606
9MP0005409_darkened_coat_color2.48133962
10MP0008961_abnormal_basal_metabolism2.32941680
11MP0003252_abnormal_bile_duct2.29525694
12MP0008057_abnormal_DNA_replication2.28449283
13MP0005451_abnormal_body_composition2.23974605
14MP0005365_abnormal_bile_salt2.20846134
15MP0005076_abnormal_cell_differentiation2.16962117
16MP0005375_adipose_tissue_phenotype2.15709580
17MP0002837_dystrophic_cardiac_calcinosis2.09267660
18MP0005085_abnormal_gallbladder_physiolo2.07518100
19MP0003950_abnormal_plasma_membrane2.02974760
20MP0009780_abnormal_chondrocyte_physiolo2.02003902
21MP0000751_myopathy1.95437366
22MP0004087_abnormal_muscle_fiber1.92770850
23MP0004084_abnormal_cardiac_muscle1.92309137
24MP0010352_gastrointestinal_tract_polyps1.88920832
25MP0002396_abnormal_hematopoietic_system1.88413248
26MP0000569_abnormal_digit_pigmentation1.87734827
27MP0010329_abnormal_lipoprotein_level1.85379029
28MP0002877_abnormal_melanocyte_morpholog1.81325552
29MP0002971_abnormal_brown_adipose1.76062294
30MP0004808_abnormal_hematopoietic_stem1.73364311
31MP0004145_abnormal_muscle_electrophysio1.72600930
32MP0000003_abnormal_adipose_tissue1.71959808
33MP0004036_abnormal_muscle_relaxation1.66407488
34MP0005670_abnormal_white_adipose1.65274009
35MP0000747_muscle_weakness1.64775388
36MP0000733_abnormal_muscle_development1.61039443
37MP0003045_fibrosis1.58240448
38MP0003566_abnormal_cell_adhesion1.55488982
39MP0005623_abnormal_meninges_morphology1.49701479
40MP0010630_abnormal_cardiac_muscle1.49183757
41MP0005257_abnormal_intraocular_pressure1.48958609
42MP0003828_pulmonary_edema1.48480235
43MP0008875_abnormal_xenobiotic_pharmacok1.46593507
44MP0001348_abnormal_lacrimal_gland1.43433030
45MP0000013_abnormal_adipose_tissue1.40661335
46MP0005023_abnormal_wound_healing1.40103212
47MP0004233_abnormal_muscle_weight1.39276320
48MP0010307_abnormal_tumor_latency1.38799502
49MP0004264_abnormal_extraembryonic_tissu1.35176572
50MP0003303_peritoneal_inflammation1.28939694
51MP0004484_altered_response_of1.26537370
52MP0010678_abnormal_skin_adnexa1.26434292
53MP0002118_abnormal_lipid_homeostasis1.26188776
54MP0004272_abnormal_basement_membrane1.25880024
55MP0000609_abnormal_liver_physiology1.25517479
56MP0002269_muscular_atrophy1.25206583
57MP0005620_abnormal_muscle_contractility1.24912140
58MP0005330_cardiomyopathy1.22142850
59MP0002006_tumorigenesis1.22009909
60MP0005083_abnormal_biliary_tract1.21909884
61MP0001730_embryonic_growth_arrest1.19876185
62MP0000759_abnormal_skeletal_muscle1.18925459
63MP0002166_altered_tumor_susceptibility1.18221241
64MP0005275_abnormal_skin_tensile1.18177217
65MP0005621_abnormal_cell_physiology1.17204382
66MP0005187_abnormal_penis_morphology1.16890400
67MP0004215_abnormal_myocardial_fiber1.16463242
68MP0003646_muscle_fatigue1.16353141
69MP0008438_abnormal_cutaneous_collagen1.16210503
70MP0002106_abnormal_muscle_physiology1.16042759
71MP0002009_preneoplasia1.15048078
72MP0000350_abnormal_cell_proliferation1.13300442
73MP0001915_intracranial_hemorrhage1.13280443
74MP0001216_abnormal_epidermal_layer1.11909885
75MP0005167_abnormal_blood-brain_barrier1.08413170
76MP0002086_abnormal_extraembryonic_tissu1.07879668
77MP0000537_abnormal_urethra_morphology1.05229013
78MP0004947_skin_inflammation1.04484954
79MP0005334_abnormal_fat_pad1.03910737
80MP0003111_abnormal_nucleus_morphology1.03778220
81MP0005501_abnormal_skin_physiology1.02997793
82MP0001661_extended_life_span1.02761557
83MP0002909_abnormal_adrenal_gland1.02614402
84MP0001666_abnormal_nutrient_absorption1.02351808
85MP0009115_abnormal_fat_cell1.01660312
86MP0000749_muscle_degeneration1.01568792
87MP0003221_abnormal_cardiomyocyte_apopto1.00542299
88MP0003091_abnormal_cell_migration1.00167042
89MP0008775_abnormal_heart_ventricle0.99701447
90MP0009053_abnormal_anal_canal0.98341072
91MP0000750_abnormal_muscle_regeneration0.97817528
92MP0003984_embryonic_growth_retardation0.97706434
93MP0000767_abnormal_smooth_muscle0.96072247
94MP0004957_abnormal_blastocyst_morpholog0.95293230
95MP0003763_abnormal_thymus_physiology0.94779864
96MP0002972_abnormal_cardiac_muscle0.94732808
97MP0001849_ear_inflammation0.93988352
98MP0002896_abnormal_bone_mineralization0.92839973
99MP0005385_cardiovascular_system_phenoty0.92637209
100MP0001544_abnormal_cardiovascular_syste0.92637209
101MP0002088_abnormal_embryonic_growth/wei0.91965627
102MP0003191_abnormal_cellular_cholesterol0.91886595
103MP0005380_embryogenesis_phenotype0.91819191
104MP0001672_abnormal_embryogenesis/_devel0.91819191
105MP0003690_abnormal_glial_cell0.90536661
106MP0001299_abnormal_eye_distance/0.89988721
107MP0005369_muscle_phenotype0.89844997
108MP0005058_abnormal_lysosome_morphology0.89002753
109MP0000428_abnormal_craniofacial_morphol0.88910621
110MP0003077_abnormal_cell_cycle0.88486360
111MP0004859_abnormal_synaptic_plasticity0.88173228
112MP0000627_abnormal_mammary_gland0.88065279
113MP0009840_abnormal_foam_cell0.85609237
114MP0001958_emphysema0.85390863
115MP0002234_abnormal_pharynx_morphology0.84626141
116MP0002796_impaired_skin_barrier0.84549855
117MP0003279_aneurysm0.84351198
118MP0009384_cardiac_valve_regurgitation0.84032541
119MP0000377_abnormal_hair_follicle0.83412571
120MP0002080_prenatal_lethality0.82690340
121MP0001851_eye_inflammation0.82552237
122MP0003656_abnormal_erythrocyte_physiolo0.80961995
123MP0001697_abnormal_embryo_size0.79922536
124MP0001853_heart_inflammation0.78660447
125MP0009672_abnormal_birth_weight0.78561905
126MP0000858_altered_metastatic_potential0.78433774
127MP0009703_decreased_birth_body0.77957432
128MP0006138_congestive_heart_failure0.77727398
129MP0002078_abnormal_glucose_homeostasis0.77216698
130MP0000266_abnormal_heart_morphology0.76434117
131MP0005410_abnormal_fertilization0.76199734
132MP0003453_abnormal_keratinocyte_physiol0.75308732
133MP0004510_myositis0.74698053
134MP0008260_abnormal_autophagy0.73622936
135MP0005384_cellular_phenotype0.73224984
136MP0009931_abnormal_skin_appearance0.73098813
137MP0008007_abnormal_cellular_replicative0.72437872
138MP0000762_abnormal_tongue_morphology0.72121165
139MP0004197_abnormal_fetal_growth/weight/0.71926185
140MP0002998_abnormal_bone_remodeling0.71750227
141MP0002128_abnormal_blood_circulation0.71059072
142MP0010368_abnormal_lymphatic_system0.71026838
143MP0005332_abnormal_amino_acid0.70924460
144MP0002970_abnormal_white_adipose0.69878169
145MP0003941_abnormal_skin_development0.68501721
146MP0000604_amyloidosis0.68174611
147MP0005319_abnormal_enzyme/_coenzyme0.65357510
148MP0002060_abnormal_skin_morphology0.64454772
149MP0001765_abnormal_ion_homeostasis0.64123991
150MP0003868_abnormal_feces_composition0.63926050
151MP0002925_abnormal_cardiovascular_devel0.63923186

Predicted human phenotypes

RankGene SetZ-score
1Hyporeflexia of lower limbs (HP:0002600)3.65490788
2Difficulty running (HP:0009046)3.55663981
3Exercise-induced muscle cramps (HP:0003710)3.36405580
4Exercise-induced myalgia (HP:0003738)3.30164515
5Protrusio acetabuli (HP:0003179)3.23494513
6Premature rupture of membranes (HP:0001788)2.98439538
7Macroorchidism (HP:0000053)2.89266456
8Deep venous thrombosis (HP:0002625)2.84823189
9Increased connective tissue (HP:0009025)2.81573972
10Arterial tortuosity (HP:0005116)2.74966366
11Type 1 muscle fiber predominance (HP:0003803)2.68194558
12Vertebral arch anomaly (HP:0008438)2.61022121
13Vascular tortuosity (HP:0004948)2.57604417
14Abnormality of oral frenula (HP:0000190)2.56009416
15Dysmetric saccades (HP:0000641)2.52745285
16Spinal cord lesions (HP:0100561)2.50535812
17Syringomyelia (HP:0003396)2.50535812
18Myoglobinuria (HP:0002913)2.48900114
19Bundle branch block (HP:0011710)2.48213616
20Distal lower limb amyotrophy (HP:0008944)2.47270494
21Hypoalphalipoproteinemia (HP:0003233)2.45320623
22Cerebral aneurysm (HP:0004944)2.43595614
23Flat acetabular roof (HP:0003180)2.42195847
24Asymmetry of the thorax (HP:0001555)2.40910140
25Right ventricular cardiomyopathy (HP:0011663)2.39918333
26Epidermoid cyst (HP:0200040)2.38955818
27Muscle fiber splitting (HP:0003555)2.38663600
28Xanthomatosis (HP:0000991)2.37938379
29Difficulty climbing stairs (HP:0003551)2.33723491
30Myocardial infarction (HP:0001658)2.32760088
31Abnormality of the Achilles tendon (HP:0005109)2.30710531
32Mitral valve prolapse (HP:0001634)2.30248495
33Sudden death (HP:0001699)2.29737879
34Relative macrocephaly (HP:0004482)2.26342926
35Abnormality of the left ventricular outflow tract (HP:0011103)2.24858306
36Subaortic stenosis (HP:0001682)2.24858306
37Achilles tendon contracture (HP:0001771)2.22197204
38Subacute progressive viral hepatitis (HP:0006572)2.20160544
39Muscle fiber inclusion bodies (HP:0100299)2.19580098
40Papilledema (HP:0001085)2.19404691
41Overgrowth (HP:0001548)2.18951167
42Aortic aneurysm (HP:0004942)2.18941086
43Insidious onset (HP:0003587)2.15612035
44Termporal pattern (HP:0011008)2.15612035
45Rectal prolapse (HP:0002035)2.15441328
46Asymmetric septal hypertrophy (HP:0001670)2.13941693
47Hamartoma of the eye (HP:0010568)2.13934091
48Short nail (HP:0001799)2.13667796
49Deep philtrum (HP:0002002)2.13284341
50Enlarged penis (HP:0000040)2.13006727
51Global brain atrophy (HP:0002283)2.12955390
52Spinal rigidity (HP:0003306)2.11730147
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11463078
54Vertebral compression fractures (HP:0002953)2.10869181
55Heterotopia (HP:0002282)2.09895033
56Broad face (HP:0000283)2.08342672
57Increased variability in muscle fiber diameter (HP:0003557)2.07088001
58Aneurysm (HP:0002617)2.06218549
59Hyperacusis (HP:0010780)2.04770865
60Wormian bones (HP:0002645)2.03377884
61Hematochezia (HP:0002573)2.02090566
62Papillary thyroid carcinoma (HP:0002895)2.00227149
63Atrophic scars (HP:0001075)1.99492469
64Spondylolisthesis (HP:0003302)1.98924271
65Centrally nucleated skeletal muscle fibers (HP:0003687)1.97061475
66Hyperlipoproteinemia (HP:0010980)1.96791903
67Ankle contracture (HP:0006466)1.95960866
68Advanced eruption of teeth (HP:0006288)1.95602256
69Abnormality of the lower motor neuron (HP:0002366)1.95289288
70Volvulus (HP:0002580)1.93981352
71Increased density of long bones (HP:0006392)1.91280087
72Buphthalmos (HP:0000557)1.90654812
73Muscle hypertrophy of the lower extremities (HP:0008968)1.89873288
74Acute myeloid leukemia (HP:0004808)1.89694985
75Ketosis (HP:0001946)1.89072311
76Complement deficiency (HP:0004431)1.89058734
77Hyperglycemia (HP:0003074)1.88647547
78Cubitus valgus (HP:0002967)1.88315041
79Dilatation of the ascending aorta (HP:0005111)1.87701375
80Scapular winging (HP:0003691)1.87593530
81Lymphangioma (HP:0100764)1.87009932
82Back pain (HP:0003418)1.86453168
83Hypoplastic ischia (HP:0003175)1.86264268
84Lower limb amyotrophy (HP:0007210)1.86056174
85Abnormality of skeletal muscle fiber size (HP:0012084)1.85671754
86Hypoglycemic coma (HP:0001325)1.85561523
87Aortic dissection (HP:0002647)1.85255493
88Shallow orbits (HP:0000586)1.85122814
89Fragile skin (HP:0001030)1.84997808
90Distal lower limb muscle weakness (HP:0009053)1.84881076
91Fatigue (HP:0012378)1.84622605
92Renovascular hypertension (HP:0100817)1.81973145
93Calf muscle hypertrophy (HP:0008981)1.81931916
94Skin nodule (HP:0200036)1.81776058
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.80989611
96Resting tremor (HP:0002322)1.80845521
97Elfin facies (HP:0004428)1.80230188
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79289634
99Obstructive sleep apnea (HP:0002870)1.78573931
100Thin bony cortex (HP:0002753)1.78445186
101Absent frontal sinuses (HP:0002688)1.77832924
102Natal tooth (HP:0000695)1.77459215
103Hypochromic microcytic anemia (HP:0004840)1.76912447
104Hypolipoproteinemia (HP:0010981)1.76683134
105Mitral regurgitation (HP:0001653)1.76419223
106Hyperkalemia (HP:0002153)1.76151826
107Ketoacidosis (HP:0001993)1.75554862
108Round ear (HP:0100830)1.75329760
109Frequent falls (HP:0002359)1.74559949
110Sparse lateral eyebrow (HP:0005338)1.73258067
111Subcapsular cataract (HP:0000523)1.73229372
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72966292
113Increased CSF protein (HP:0002922)1.72899731
114Acanthocytosis (HP:0001927)1.72363433
115Insomnia (HP:0100785)1.71904251
116Ulnar deviation of the wrist (HP:0003049)1.71302710
117Conjunctival hamartoma (HP:0100780)1.70974574
118Nemaline bodies (HP:0003798)1.69681238
119Disinhibition (HP:0000734)1.69160563
120Atrioventricular block (HP:0001678)1.69048669
121Muscle stiffness (HP:0003552)1.68137939
122Germ cell neoplasia (HP:0100728)1.67298958
123Exostoses (HP:0100777)1.67204924
124Dislocated radial head (HP:0003083)1.66829652
125Mildly elevated creatine phosphokinase (HP:0008180)1.66413352
126Abnormality of the distal phalanges of the toes (HP:0010182)1.65267727
127Osteolytic defects of the hand bones (HP:0009699)1.65152510
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.65152510
129Abnormality of the ischium (HP:0003174)1.65082073
130Deviation of the thumb (HP:0009603)1.65049651
131Disproportionate tall stature (HP:0001519)1.64399924
132Ulnar bowing (HP:0003031)1.64021545
133Broad metatarsal (HP:0001783)1.63916485
134Hallux valgus (HP:0001822)1.61229098
135Long eyelashes (HP:0000527)1.59497398
136Curly hair (HP:0002212)1.59424312
137Cerebral inclusion bodies (HP:0100314)1.59378348
138Ankyloglossia (HP:0010296)1.59316248
139Poikilocytosis (HP:0004447)1.58183579
140EMG: myopathic abnormalities (HP:0003458)1.58115690
141EMG: neuropathic changes (HP:0003445)1.57569236
142Abnormality of the common coagulation pathway (HP:0010990)1.57349328
143Long toe (HP:0010511)1.57237696
144Intrahepatic cholestasis (HP:0001406)1.56904721
145Microglossia (HP:0000171)1.56882465
146Truncal obesity (HP:0001956)1.56801365
147Deviation of the hallux (HP:0010051)1.56746463
148Distal upper limb amyotrophy (HP:0007149)1.56740105
149Upper limb amyotrophy (HP:0009129)1.56740105
150Elbow flexion contracture (HP:0002987)1.56149602
151Renal cell carcinoma (HP:0005584)1.54971951
152Coarse hair (HP:0002208)1.53628801
153Bladder diverticulum (HP:0000015)1.53546318
154Increased nuchal translucency (HP:0010880)1.52439724
155Abnormality of the thoracic spine (HP:0100711)1.52344505
156Decreased motor nerve conduction velocity (HP:0003431)1.52125868
157Reduced subcutaneous adipose tissue (HP:0003758)1.52117702
158Abnormality of nail color (HP:0100643)1.51538199
159Abnormality of the fingertips (HP:0001211)1.50638482
160Uterine leiomyosarcoma (HP:0002891)1.50190048
161Leiomyosarcoma (HP:0100243)1.50190048
162Hammertoe (HP:0001765)1.49675425
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.49148431
164Abnormal ossification of hand bones (HP:0005921)1.48705811
165Missing ribs (HP:0000921)1.47723454
166Thoracolumbar scoliosis (HP:0002944)1.47418417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.69463277
2PRPF4B3.61923165
3PKN22.96879066
4TTN2.90837776
5LATS12.64859687
6DMPK2.23990320
7PDK32.18493756
8PDK42.18493756
9CAMK1G2.09502849
10IRAK32.07738451
11EEF2K2.07473400
12RIPK12.05635556
13CAMK1D2.04272579
14CDK122.03338350
15FRK1.96178184
16MAP3K101.84812705
17SIK11.72811802
18PTK61.71306304
19SMG11.70199780
20MAP3K131.64104707
21PDGFRA1.62618972
22FGFR21.54427865
23BRD41.48892942
24CDK61.44742123
25PRKD31.43977764
26MAP3K141.38782608
27MAP3K71.37478258
28MET1.35916000
29LMTK21.31771532
30NTRK11.30477439
31FGFR31.29299706
32STK31.28341926
33SCYL21.19582041
34RET1.18705879
35EIF2AK11.17225316
36WNK11.16711787
37PDGFRB1.16093465
38AKT31.13575917
39STK241.11606836
40STK381.05729278
41ICK1.03708073
42CAMKK11.03035455
43EPHA21.02813501
44PHKG20.99865244
45PHKG10.99865244
46SIK20.98386086
47LRRK20.98192597
48PDK20.97801546
49MAP2K40.97046024
50SGK30.96987912
51TYRO30.95940564
52MTOR0.95356103
53CDK90.94347290
54RPS6KB20.93665862
55PDK10.93623817
56MAP3K20.92603221
57KSR20.90981131
58ALK0.90935767
59MOS0.90412252
60PIK3CA0.90118934
61BMX0.89929914
62PAK60.88626945
63TAOK10.87787903
64DDR20.87755368
65MST1R0.84494691
66PDPK10.82575258
67PAK40.82347429
68PRKCH0.80543717
69ERBB40.80363692
70NEK20.79410515
71MAP3K80.79337308
72PRKAA10.78604115
73OBSCN0.78353275
74ZAP700.78278976
75TRPM70.77683752
76FGFR40.76670385
77TAF10.75666465
78JAK10.75098692
79PRKAA20.74544544
80NEK10.73686983
81NUAK10.71869433
82BMPR20.69893792
83ERN10.69703777
84STK100.69572356
85EIF2AK30.68682543
86PAK20.68438083
87MAP3K40.68254606
88PNCK0.67324526
89MAP2K30.67157719
90MAP3K10.66940639
91MELK0.66819512
92TAOK30.66495466
93CDC42BPA0.65624477
94DYRK1B0.65106320
95NEK90.64836456
96PRKD10.63823647
97YES10.62717062
98EPHB10.62029884
99LATS20.60369813
100MAPK110.59683830
101TSSK60.59606000
102SIK30.58399607
103MAP3K30.57176051
104TTK0.56977829
105CDK40.56956343
106MAPK120.56685993
107STK110.56641759
108PAK30.56397273
109CDK70.56344665
110JAK20.55892202
111MAP3K90.55825236
112FGFR10.54618648
113PTK2B0.54437737
114BRAF0.54054946
115SGK10.51212342
116RAF10.50430272
117GSK3A0.49708999
118TAOK20.49393594
119ERBB30.48741246
120TGFBR20.48003246
121PTK20.47802628
122CDK80.47528529
123CHEK10.47516209
124MAPK70.46935799
125CLK10.45848457
126FER0.45316773
127MAP3K50.45184266
128ILK0.44515972
129KSR10.41922048
130MAP2K10.41904369
131HIPK20.41388710
132WNK40.41048669
133MAP3K60.40155166
134AKT20.39212938
135RPS6KA30.38831177
136MAPK100.38486926
137NTRK30.38216475
138MARK20.38145804
139ROCK20.37588086
140PRKD20.37442646
141IRAK20.36793527
142EPHA40.36586374
143RIPK40.36541097
144CSNK1D0.36307854

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.69913937
2Thyroid cancer_Homo sapiens_hsa052161.87970247
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81140064
4Fatty acid degradation_Homo sapiens_hsa000711.73934707
5PPAR signaling pathway_Homo sapiens_hsa033201.72189279
6Fatty acid biosynthesis_Homo sapiens_hsa000611.71656896
7Arginine biosynthesis_Homo sapiens_hsa002201.68867278
8Propanoate metabolism_Homo sapiens_hsa006401.67526996
9Acute myeloid leukemia_Homo sapiens_hsa052211.65992888
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53099195
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51245354
12Bladder cancer_Homo sapiens_hsa052191.50392474
13Lysine degradation_Homo sapiens_hsa003101.47419926
14Fatty acid metabolism_Homo sapiens_hsa012121.43805281
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42491057
16Insulin resistance_Homo sapiens_hsa049311.38396511
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.36587879
18Glucagon signaling pathway_Homo sapiens_hsa049221.34570793
19Bile secretion_Homo sapiens_hsa049761.31599122
20Dorso-ventral axis formation_Homo sapiens_hsa043201.28455654
21mTOR signaling pathway_Homo sapiens_hsa041501.25147332
22Hepatitis B_Homo sapiens_hsa051611.23249496
23Colorectal cancer_Homo sapiens_hsa052101.21140037
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.21114545
25AMPK signaling pathway_Homo sapiens_hsa041521.19866805
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19649245
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18695705
28Type II diabetes mellitus_Homo sapiens_hsa049301.18242984
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16084921
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11566521
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10841071
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08588834
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07736290
34Glioma_Homo sapiens_hsa052141.07550180
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05303621
36Insulin signaling pathway_Homo sapiens_hsa049101.05211524
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03319233
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03229379
39Dilated cardiomyopathy_Homo sapiens_hsa054141.02844513
40Caffeine metabolism_Homo sapiens_hsa002321.02810479
41Prion diseases_Homo sapiens_hsa050201.01928346
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01737688
43Chronic myeloid leukemia_Homo sapiens_hsa052200.98903996
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98391502
45Long-term potentiation_Homo sapiens_hsa047200.98043605
46Focal adhesion_Homo sapiens_hsa045100.97806793
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97524649
48Tryptophan metabolism_Homo sapiens_hsa003800.95973551
49Gastric acid secretion_Homo sapiens_hsa049710.95937190
50Renin secretion_Homo sapiens_hsa049240.95684058
51Estrogen signaling pathway_Homo sapiens_hsa049150.93894231
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92940235
53Non-small cell lung cancer_Homo sapiens_hsa052230.92139443
54Cell cycle_Homo sapiens_hsa041100.91332145
55TNF signaling pathway_Homo sapiens_hsa046680.90300423
56VEGF signaling pathway_Homo sapiens_hsa043700.88642230
57Circadian rhythm_Homo sapiens_hsa047100.88399133
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88378705
59Hepatitis C_Homo sapiens_hsa051600.87735460
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.86988191
61Proteoglycans in cancer_Homo sapiens_hsa052050.86781959
62Butanoate metabolism_Homo sapiens_hsa006500.85937269
63Complement and coagulation cascades_Homo sapiens_hsa046100.84999244
64Glycerolipid metabolism_Homo sapiens_hsa005610.83573221
65Adherens junction_Homo sapiens_hsa045200.83182337
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83032598
67Notch signaling pathway_Homo sapiens_hsa043300.82748108
68Starch and sucrose metabolism_Homo sapiens_hsa005000.82704716
69Shigellosis_Homo sapiens_hsa051310.81533845
70Viral carcinogenesis_Homo sapiens_hsa052030.81314659
71Melanoma_Homo sapiens_hsa052180.80385597
72Oxytocin signaling pathway_Homo sapiens_hsa049210.80355584
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80351380
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79863565
75GnRH signaling pathway_Homo sapiens_hsa049120.79783874
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79266362
77Apoptosis_Homo sapiens_hsa042100.78673213
78Pancreatic cancer_Homo sapiens_hsa052120.78658197
79Endometrial cancer_Homo sapiens_hsa052130.78564943
80Pyruvate metabolism_Homo sapiens_hsa006200.78069225
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77953155
82Toxoplasmosis_Homo sapiens_hsa051450.77648668
83Carbon metabolism_Homo sapiens_hsa012000.76629726
84Other glycan degradation_Homo sapiens_hsa005110.76334275
85Renal cell carcinoma_Homo sapiens_hsa052110.76164754
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.75313969
87Fat digestion and absorption_Homo sapiens_hsa049750.74584480
88Pathways in cancer_Homo sapiens_hsa052000.74515235
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74322321
90Platelet activation_Homo sapiens_hsa046110.72773929
91T cell receptor signaling pathway_Homo sapiens_hsa046600.72772404
92Influenza A_Homo sapiens_hsa051640.71409468
93HIF-1 signaling pathway_Homo sapiens_hsa040660.70255808
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70037785
95Thyroid hormone synthesis_Homo sapiens_hsa049180.69984163
96HTLV-I infection_Homo sapiens_hsa051660.68922914
97ABC transporters_Homo sapiens_hsa020100.67811356
98mRNA surveillance pathway_Homo sapiens_hsa030150.67575813
99Amoebiasis_Homo sapiens_hsa051460.67283005
100Salivary secretion_Homo sapiens_hsa049700.67245195
101FoxO signaling pathway_Homo sapiens_hsa040680.67098326
102Measles_Homo sapiens_hsa051620.65947008
103Endocytosis_Homo sapiens_hsa041440.65884209
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65231424
105Gap junction_Homo sapiens_hsa045400.64456779
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62285486
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61963335
108Small cell lung cancer_Homo sapiens_hsa052220.60878171
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60369042
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.59775451
111B cell receptor signaling pathway_Homo sapiens_hsa046620.59208944
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58857356
113cAMP signaling pathway_Homo sapiens_hsa040240.58293292
114Pentose phosphate pathway_Homo sapiens_hsa000300.56383385
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56314303
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.56296359
117MicroRNAs in cancer_Homo sapiens_hsa052060.55793474
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54970213
119TGF-beta signaling pathway_Homo sapiens_hsa043500.54704074
120Prolactin signaling pathway_Homo sapiens_hsa049170.54613005
121ECM-receptor interaction_Homo sapiens_hsa045120.54473509
122Melanogenesis_Homo sapiens_hsa049160.54205819
123Inositol phosphate metabolism_Homo sapiens_hsa005620.53883143
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.53390153
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53199540
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53182710
127ErbB signaling pathway_Homo sapiens_hsa040120.52861747
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52588350
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.52112239
130MAPK signaling pathway_Homo sapiens_hsa040100.51846050
131Tight junction_Homo sapiens_hsa045300.50743391
132Pancreatic secretion_Homo sapiens_hsa049720.50509078
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50494579
134Prostate cancer_Homo sapiens_hsa052150.50437356
135Choline metabolism in cancer_Homo sapiens_hsa052310.50276810
136Olfactory transduction_Homo sapiens_hsa047400.49480747
137Rap1 signaling pathway_Homo sapiens_hsa040150.49360696
138Insulin secretion_Homo sapiens_hsa049110.49010691
139Osteoclast differentiation_Homo sapiens_hsa043800.48876493
140Hippo signaling pathway_Homo sapiens_hsa043900.48695329
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.47439367
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47155345

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »