ZFP91-CNTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a read-through transcript composed of ZFP91 and CNTF sequence. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). Read-through transcription of ZFP91 and CNTF has also been observed in mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.20943463
2sperm motility (GO:0030317)6.10410072
3single strand break repair (GO:0000012)5.49414071
4rRNA methylation (GO:0031167)5.04963527
5response to pheromone (GO:0019236)4.98655804
6protein polyglutamylation (GO:0018095)4.83596084
7protein targeting to Golgi (GO:0000042)4.75233443
8rRNA modification (GO:0000154)4.74510513
9establishment of protein localization to Golgi (GO:0072600)4.66893086
10centriole replication (GO:0007099)4.65461912
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.55456781
12microtubule depolymerization (GO:0007019)4.38724665
13spermatid development (GO:0007286)4.33629849
14DNA packaging (GO:0006323)4.18848508
15chromosome condensation (GO:0030261)4.18467899
16epithelial cilium movement (GO:0003351)4.04034387
17fusion of sperm to egg plasma membrane (GO:0007342)3.98348525
18sperm capacitation (GO:0048240)3.95989669
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.94920730
20multicellular organism reproduction (GO:0032504)3.91612440
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88429218
22protein localization to Golgi apparatus (GO:0034067)3.83297802
23microtubule severing (GO:0051013)3.80282990
24spermatid nucleus differentiation (GO:0007289)3.79861430
25behavioral response to nicotine (GO:0035095)3.79090639
26calcium ion-dependent exocytosis (GO:0017156)3.76164272
27regulation of cilium movement (GO:0003352)3.72108881
28sperm-egg recognition (GO:0035036)3.68167176
29regulation of centriole replication (GO:0046599)3.51698894
30centriole assembly (GO:0098534)3.46631869
31microtubule polymerization or depolymerization (GO:0031109)3.42299879
32cilium movement (GO:0003341)3.35264930
33axonemal dynein complex assembly (GO:0070286)3.30390174
34RNA destabilization (GO:0050779)3.24579840
35cellular ketone body metabolic process (GO:0046950)3.18912164
36binding of sperm to zona pellucida (GO:0007339)3.17827957
37male gamete generation (GO:0048232)3.17819039
38spermatogenesis (GO:0007283)3.17530674
39plasma membrane fusion (GO:0045026)3.17255659
40regulation of DNA endoreduplication (GO:0032875)3.06885623
41seminiferous tubule development (GO:0072520)3.03612427
42intraciliary transport (GO:0042073)3.01595966
43reproduction (GO:0000003)3.00237307
44gamete generation (GO:0007276)2.99205159
45cell-cell recognition (GO:0009988)2.94155471
46protein complex biogenesis (GO:0070271)2.88411133
47histone exchange (GO:0043486)2.84931364
48ketone body metabolic process (GO:1902224)2.82562238
49mitochondrial respiratory chain complex I assembly (GO:0032981)2.80580933
50NADH dehydrogenase complex assembly (GO:0010257)2.80580933
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80580933
52chromatin silencing (GO:0006342)2.78182767
53replication fork processing (GO:0031297)2.77334639
54cell proliferation in forebrain (GO:0021846)2.76430629
55mechanosensory behavior (GO:0007638)2.74740429
56retina layer formation (GO:0010842)2.71879004
57mitochondrial respiratory chain complex assembly (GO:0033108)2.71481649
58male meiosis I (GO:0007141)2.66665619
59auditory behavior (GO:0031223)2.63194401
60spinal cord motor neuron differentiation (GO:0021522)2.60005596
61regulation of meiosis I (GO:0060631)2.59448029
62single fertilization (GO:0007338)2.56238254
63cilium organization (GO:0044782)2.54242252
64neurofilament cytoskeleton organization (GO:0060052)2.50798446
65germ cell development (GO:0007281)2.50271587
66cilium assembly (GO:0042384)2.50012606
67forebrain neuron differentiation (GO:0021879)2.49521770
68nonmotile primary cilium assembly (GO:0035058)2.49089479
69regulation of telomere maintenance (GO:0032204)2.46467654
70chaperone-mediated protein transport (GO:0072321)2.45962124
71urogenital system development (GO:0001655)2.45613382
72limb development (GO:0060173)2.41421662
73appendage development (GO:0048736)2.41421662
74regulation of hexokinase activity (GO:1903299)2.41051736
75regulation of glucokinase activity (GO:0033131)2.41051736
76regulation of transcription involved in cell fate commitment (GO:0060850)2.39439393
77ventricular system development (GO:0021591)2.39138470
78multicellular organismal movement (GO:0050879)2.38577686
79musculoskeletal movement (GO:0050881)2.38577686
80otic vesicle formation (GO:0030916)2.37859197
81protein neddylation (GO:0045116)2.37617835
82regulation of microtubule-based movement (GO:0060632)2.36221761
83negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36180126
84phosphatidylethanolamine biosynthetic process (GO:0006646)2.34778841
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.33207220
86negative regulation of inclusion body assembly (GO:0090084)2.33026334
87multicellular organismal reproductive process (GO:0048609)2.32091276
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.30915618
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.29498326
90cilium or flagellum-dependent cell motility (GO:0001539)2.28570139
91phosphatidylethanolamine metabolic process (GO:0046337)2.27202623
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.25675839
93response to auditory stimulus (GO:0010996)2.25065843
94axoneme assembly (GO:0035082)2.24108278
95pattern specification involved in kidney development (GO:0061004)2.24004335
96postsynaptic membrane organization (GO:0001941)2.23358722
97somite development (GO:0061053)2.23175245
98DNA methylation involved in gamete generation (GO:0043046)2.22289890
99nephron epithelium morphogenesis (GO:0072088)2.21960102
100nephron tubule morphogenesis (GO:0072078)2.21960102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15155825
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.21837957
3VDR_22108803_ChIP-Seq_LS180_Human2.48067308
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42823468
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42418176
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40147681
7ZNF274_21170338_ChIP-Seq_K562_Hela2.38508191
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36815758
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35791503
10FUS_26573619_Chip-Seq_HEK293_Human2.35275341
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.34767069
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34298435
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24849005
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.13148982
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09434966
16POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.02489690
17TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02489690
18GBX2_23144817_ChIP-Seq_PC3_Human1.86234083
19P300_19829295_ChIP-Seq_ESCs_Human1.83029625
20TAF15_26573619_Chip-Seq_HEK293_Human1.78744076
21CBP_20019798_ChIP-Seq_JUKART_Human1.73759902
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73759902
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72135222
24EWS_26573619_Chip-Seq_HEK293_Human1.63658891
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62965850
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.55726526
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54268311
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.53778778
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53242126
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53104242
31IGF1R_20145208_ChIP-Seq_DFB_Human1.52162133
32REST_21632747_ChIP-Seq_MESCs_Mouse1.46505269
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46386768
34AR_25329375_ChIP-Seq_VCAP_Human1.45614383
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44530117
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42131375
37SMAD4_21799915_ChIP-Seq_A2780_Human1.40683088
38ER_23166858_ChIP-Seq_MCF-7_Human1.38440783
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37830937
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.37791950
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37124776
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36730101
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34688821
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33830922
45RNF2_27304074_Chip-Seq_NSC_Mouse1.33573129
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.33090488
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.32458245
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32145659
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26575262
50STAT3_23295773_ChIP-Seq_U87_Human1.25408916
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.25382916
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25217244
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24189950
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23813422
55ETV1_20927104_ChIP-Seq_GIST48_Human1.20450961
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20354868
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20288100
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.20138188
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19206007
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18512174
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.17130515
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.16668004
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13987880
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12175913
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12165643
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.12095912
67NFYB_21822215_ChIP-Seq_K562_Human1.11770278
68MYC_18940864_ChIP-ChIP_HL60_Human1.10612529
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10129126
70TBL1_22424771_ChIP-Seq_293T_Human1.08975313
71RBPJ_21746931_ChIP-Seq_IB4_Human1.08910207
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08149701
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08148112
74IRF1_19129219_ChIP-ChIP_H3396_Human1.07675858
75ERA_21632823_ChIP-Seq_H3396_Human1.07616227
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07607825
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.07104048
78TCF4_23295773_ChIP-Seq_U87_Human1.06967942
79RUNX2_22187159_ChIP-Seq_PCA_Human1.05931699
80SOX2_19829295_ChIP-Seq_ESCs_Human1.05738973
81NANOG_19829295_ChIP-Seq_ESCs_Human1.05738973
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05735460
83PHF8_20622853_ChIP-Seq_HELA_Human1.04998470
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.03294468
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02805880
86CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02036131
87TP53_22573176_ChIP-Seq_HFKS_Human1.01057155
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00862684
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00834982
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00821747
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00622680
92NFYA_21822215_ChIP-Seq_K562_Human1.00152421
93SOX9_26525672_Chip-Seq_HEART_Mouse0.97240661
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96115033
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95983280
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95280099
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.94990830
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94052257
99MYC_19829295_ChIP-Seq_ESCs_Human0.93476469
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92646780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.08374108
2MP0006292_abnormal_olfactory_placode4.04717928
3MP0002837_dystrophic_cardiac_calcinosis3.47123138
4MP0000569_abnormal_digit_pigmentation2.52832128
5MP0001485_abnormal_pinna_reflex2.43124130
6MP0005377_hearing/vestibular/ear_phenot2.39925988
7MP0003878_abnormal_ear_physiology2.39925988
8MP0003646_muscle_fatigue2.23510771
9MP0008877_abnormal_DNA_methylation2.14637839
10MP0004215_abnormal_myocardial_fiber2.06922104
11MP0003698_abnormal_male_reproductive2.00435735
12MP0001929_abnormal_gametogenesis1.88916412
13MP0003787_abnormal_imprinting1.75089260
14MP0006072_abnormal_retinal_apoptosis1.74413926
15MP0002938_white_spotting1.72297315
16MP0005670_abnormal_white_adipose1.69493798
17MP0003136_yellow_coat_color1.65076321
18MP0005551_abnormal_eye_electrophysiolog1.64464972
19MP0002234_abnormal_pharynx_morphology1.61498198
20MP0000778_abnormal_nervous_system1.59293015
21MP0004084_abnormal_cardiac_muscle1.57720715
22MP0000631_abnormal_neuroendocrine_gland1.54916525
23MP0006276_abnormal_autonomic_nervous1.54867746
24MP0003011_delayed_dark_adaptation1.54431909
25MP0002272_abnormal_nervous_system1.54085347
26MP0003880_abnormal_central_pattern1.53848996
27MP0003121_genomic_imprinting1.52449182
28MP0001293_anophthalmia1.50113917
29MP0008995_early_reproductive_senescence1.49689101
30MP0005253_abnormal_eye_physiology1.48333674
31MP0005645_abnormal_hypothalamus_physiol1.46090102
32MP0009379_abnormal_foot_pigmentation1.42521798
33MP0009046_muscle_twitch1.41350914
34MP0003718_maternal_effect1.38420676
35MP0001486_abnormal_startle_reflex1.37278001
36MP0001968_abnormal_touch/_nociception1.37202102
37MP0005379_endocrine/exocrine_gland_phen1.36573480
38MP0000372_irregular_coat_pigmentation1.36387164
39MP0002210_abnormal_sex_determination1.35460049
40MP0001905_abnormal_dopamine_level1.34626121
41MP0003137_abnormal_impulse_conducting1.34593548
42MP0002557_abnormal_social/conspecific_i1.31278234
43MP0008057_abnormal_DNA_replication1.31265523
44MP0004742_abnormal_vestibular_system1.30722793
45MP0005423_abnormal_somatic_nervous1.29871485
46MP0002736_abnormal_nociception_after1.28931685
47MP0008058_abnormal_DNA_repair1.27342739
48MP0005174_abnormal_tail_pigmentation1.26017894
49MP0000049_abnormal_middle_ear1.24483793
50MP0002638_abnormal_pupillary_reflex1.20169834
51MP0000015_abnormal_ear_pigmentation1.20076860
52MP0009745_abnormal_behavioral_response1.19173871
53MP0002095_abnormal_skin_pigmentation1.15096394
54MP0002735_abnormal_chemical_nociception1.13879726
55MP0000955_abnormal_spinal_cord1.10742673
56MP0004133_heterotaxia1.10547564
57MP0000026_abnormal_inner_ear1.09796506
58MP0003283_abnormal_digestive_organ1.09697312
59MP0002127_abnormal_cardiovascular_syste1.08509035
60MP0008789_abnormal_olfactory_epithelium1.06938128
61MP0002161_abnormal_fertility/fecundity1.05776787
62MP0004142_abnormal_muscle_tone1.05151645
63MP0002067_abnormal_sensory_capabilities1.03700530
64MP0004085_abnormal_heartbeat1.02763440
65MP0003123_paternal_imprinting1.01843273
66MP0002163_abnormal_gland_morphology1.01756503
67MP0004145_abnormal_muscle_electrophysio1.01217242
68MP0002102_abnormal_ear_morphology1.00802799
69MP0008775_abnormal_heart_ventricle1.00438970
70MP0000653_abnormal_sex_gland1.00022385
71MP0001145_abnormal_male_reproductive0.99959024
72MP0001963_abnormal_hearing_physiology0.98040570
73MP0002160_abnormal_reproductive_system0.97617019
74MP0001529_abnormal_vocalization0.96940209
75MP0003635_abnormal_synaptic_transmissio0.96104039
76MP0002752_abnormal_somatic_nervous0.95342546
77MP0001984_abnormal_olfaction0.95336726
78MP0002572_abnormal_emotion/affect_behav0.94644990
79MP0002184_abnormal_innervation0.91680850
80MP0005391_vision/eye_phenotype0.90722293
81MP0002734_abnormal_mechanical_nocicepti0.90014917
82MP0000566_synostosis0.89469420
83MP0004859_abnormal_synaptic_plasticity0.88022156
84MP0005195_abnormal_posterior_eye0.87990118
85MP0001188_hyperpigmentation0.87904859
86MP0004885_abnormal_endolymph0.86454772
87MP0002882_abnormal_neuron_morphology0.86039250
88MP0002928_abnormal_bile_duct0.86022474
89MP0005394_taste/olfaction_phenotype0.83866994
90MP0005499_abnormal_olfactory_system0.83866994
91MP0010094_abnormal_chromosome_stability0.83758839
92MP0002733_abnormal_thermal_nociception0.82127528
93MP0003195_calcinosis0.81273687
94MP0005408_hypopigmentation0.78302434
95MP0005646_abnormal_pituitary_gland0.77933693
96MP0003861_abnormal_nervous_system0.77611354
97MP0001324_abnormal_eye_pigmentation0.77371047
98MP0003937_abnormal_limbs/digits/tail_de0.77142944
99MP0003693_abnormal_embryo_hatching0.76767935
100MP0002064_seizures0.75667983

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.07953609
2Pancreatic cysts (HP:0001737)3.31318218
3Abnormality of midbrain morphology (HP:0002418)3.30627651
4Molar tooth sign on MRI (HP:0002419)3.30627651
5Chronic hepatic failure (HP:0100626)3.28041328
6Pancreatic fibrosis (HP:0100732)3.27617416
7Nephronophthisis (HP:0000090)3.24002474
8Renal Fanconi syndrome (HP:0001994)3.13412387
9Acute necrotizing encephalopathy (HP:0006965)3.04648041
10Septo-optic dysplasia (HP:0100842)2.87401038
11Bony spicule pigmentary retinopathy (HP:0007737)2.86760371
12Tubulointerstitial nephritis (HP:0001970)2.83492756
13Abnormal rod and cone electroretinograms (HP:0008323)2.81994466
14Attenuation of retinal blood vessels (HP:0007843)2.75028543
15Abnormality of renal resorption (HP:0011038)2.74655787
16Abnormality of the renal medulla (HP:0100957)2.73992080
17Absent/shortened dynein arms (HP:0200106)2.68228779
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.68228779
19Hypoplastic ischia (HP:0003175)2.67644733
20True hermaphroditism (HP:0010459)2.66450359
21Optic nerve hypoplasia (HP:0000609)2.65516067
22Increased hepatocellular lipid droplets (HP:0006565)2.61879355
23Abnormal ciliary motility (HP:0012262)2.54960396
24Progressive macrocephaly (HP:0004481)2.54783879
25Volvulus (HP:0002580)2.53470918
26Acute encephalopathy (HP:0006846)2.52311042
27Abnormal mitochondria in muscle tissue (HP:0008316)2.48579514
28Congenital stationary night blindness (HP:0007642)2.47752756
29Sclerocornea (HP:0000647)2.44852025
30Lipid accumulation in hepatocytes (HP:0006561)2.43620182
31Abnormal number of incisors (HP:0011064)2.43025805
32Pendular nystagmus (HP:0012043)2.41474004
33Mitochondrial inheritance (HP:0001427)2.40708259
34Abnormality of the renal cortex (HP:0011035)2.36876141
35Anencephaly (HP:0002323)2.33937971
36Abnormal respiratory motile cilium physiology (HP:0012261)2.33803663
37Increased CSF lactate (HP:0002490)2.31608399
38Abnormality of macular pigmentation (HP:0008002)2.28529609
39Type II lissencephaly (HP:0007260)2.24248528
40Abnormality of the ischium (HP:0003174)2.21022884
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20865807
42Oligodactyly (hands) (HP:0001180)2.19929368
43Growth hormone deficiency (HP:0000824)2.17486991
44Glycosuria (HP:0003076)2.17118606
45Abnormality of urine glucose concentration (HP:0011016)2.17118606
46Abnormality of the labia minora (HP:0012880)2.13706074
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10009618
48Cystic liver disease (HP:0006706)2.08660918
49Medial flaring of the eyebrow (HP:0010747)2.07103418
50Abnormal respiratory epithelium morphology (HP:0012253)2.02369406
51Abnormal respiratory motile cilium morphology (HP:0005938)2.02369406
52Generalized aminoaciduria (HP:0002909)2.01236669
53Congenital malformation of the right heart (HP:0011723)1.99113914
54Double outlet right ventricle (HP:0001719)1.99113914
55Esophageal atresia (HP:0002032)1.96088177
56Impulsivity (HP:0100710)1.94644822
57Postaxial foot polydactyly (HP:0001830)1.93742912
58Polyuria (HP:0000103)1.91257589
59Aplasia/Hypoplasia of the tibia (HP:0005772)1.90546522
60Polydipsia (HP:0001959)1.88963277
61Abnormal drinking behavior (HP:0030082)1.88963277
62Abnormality of the aortic arch (HP:0012303)1.88145577
63Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88036468
64Optic disc pallor (HP:0000543)1.87955176
65Pachygyria (HP:0001302)1.87942332
66Intellectual disability, moderate (HP:0002342)1.87529833
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86970547
68Cerebellar dysplasia (HP:0007033)1.86307131
69Absent septum pellucidum (HP:0001331)1.85732099
70Renal cortical cysts (HP:0000803)1.85446979
71Preaxial hand polydactyly (HP:0001177)1.85150382
72Exertional dyspnea (HP:0002875)1.83760301
73Anophthalmia (HP:0000528)1.82930388
74Cerebral edema (HP:0002181)1.81533107
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80626250
76Progressive cerebellar ataxia (HP:0002073)1.79848199
77Hepatic necrosis (HP:0002605)1.79262646
78Short tibia (HP:0005736)1.79053434
79Median cleft lip (HP:0000161)1.78443648
80Rib fusion (HP:0000902)1.75567022
81Tubular atrophy (HP:0000092)1.74314374
82Truncal obesity (HP:0001956)1.73995789
83Gastrointestinal atresia (HP:0002589)1.73328863
84Gait imbalance (HP:0002141)1.72367473
85Congenital sensorineural hearing impairment (HP:0008527)1.71965929
86Decreased central vision (HP:0007663)1.70083698
87Abnormal urine output (HP:0012590)1.68064761
88Occipital encephalocele (HP:0002085)1.68038928
89Congenital hepatic fibrosis (HP:0002612)1.67907822
90Sloping forehead (HP:0000340)1.67571385
91Adrenal hypoplasia (HP:0000835)1.67246622
92Hypoplasia of the fovea (HP:0007750)1.64327475
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.64327475
94Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62856270
95Congenital primary aphakia (HP:0007707)1.62642521
96Poor coordination (HP:0002370)1.62310092
97Holoprosencephaly (HP:0001360)1.61395609
98Scotoma (HP:0000575)1.61263143
99Abnormality of the septum pellucidum (HP:0007375)1.59738277
100Prolonged QT interval (HP:0001657)1.59396156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.77189213
2PLK43.84960419
3CAMK1G2.77462372
4INSRR2.49183055
5CASK2.37152749
6MAP4K22.32975829
7CDC72.21417508
8PINK11.95088232
9FRK1.89673146
10BMPR1B1.85712828
11NUAK11.82544189
12TNIK1.82085782
13MARK11.78936633
14MAP3K41.78136680
15WNK31.62536544
16BRD41.60357099
17TLK11.59896874
18STK161.58406777
19MAPK151.57851201
20MAP2K71.53134162
21VRK11.52317961
22GRK11.52066147
23ZAK1.49172733
24PLK21.46337601
25CAMK1D1.43434696
26MKNK21.43391763
27STK391.40724458
28DYRK21.31500199
29ADRBK21.29757047
30WNK41.23259777
31EPHA41.14249525
32STK38L1.12975626
33DMPK1.08354144
34TIE11.07216092
35PAK31.06911817
36OXSR11.03544852
37NEK21.01516407
38DDR21.00116671
39PRKCG0.95605531
40TSSK60.93347662
41TRIM280.87564891
42DYRK30.87498233
43CDK30.86609945
44MST40.86529206
45TAF10.85253758
46SGK20.84618699
47AURKA0.84480082
48MAP3K90.82597120
49UHMK10.80742863
50PLK10.80605547
51PRKG10.80057860
52DAPK30.77878974
53SGK4940.77321355
54SGK2230.77321355
55BRSK20.75733807
56MARK30.73603535
57AKT30.68929184
58MAPK130.68621010
59CHEK10.66938923
60NEK10.66763346
61PRKCE0.65752114
62CHEK20.65593156
63PLK30.64687355
64ATM0.64186386
65SRPK10.64106288
66WNK10.64009773
67ROCK10.63747836
68ATR0.63490904
69MUSK0.63230733
70BCKDK0.62992515
71WEE10.62392379
72NTRK20.61516626
73PRKCI0.60908352
74CAMK10.59854484
75CSNK1E0.59620762
76NME10.59236839
77SIK20.57338500
78PKN10.57301455
79CDK20.56459336
80MINK10.55018886
81AURKB0.53727232
82RPS6KA50.53050377
83ABL20.51399492
84PTK2B0.51136075
85CDK10.50801079
86PRKACA0.50679971
87GSK3B0.48782446
88DYRK1B0.46726503
89MKNK10.46101755
90TAOK10.45945416
91CAMK2A0.45231785
92PRKACB0.44958682
93PRKCZ0.43101987
94MAP2K40.42701728
95CSNK2A20.42023749
96OBSCN0.41611810
97STK110.40880041
98CSNK1G10.40772698
99CCNB10.39865663
100SGK10.39378492

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.91572237
2Cardiac muscle contraction_Homo sapiens_hsa042603.44961188
3Oxidative phosphorylation_Homo sapiens_hsa001903.07778656
4Parkinsons disease_Homo sapiens_hsa050122.72712132
5Ribosome_Homo sapiens_hsa030102.34376871
6Huntingtons disease_Homo sapiens_hsa050162.33592391
7Nicotine addiction_Homo sapiens_hsa050332.29884115
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.28405665
9RNA polymerase_Homo sapiens_hsa030202.26389891
10Fanconi anemia pathway_Homo sapiens_hsa034602.16021736
11Butanoate metabolism_Homo sapiens_hsa006502.12255733
12Homologous recombination_Homo sapiens_hsa034402.01196868
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86767201
14Phototransduction_Homo sapiens_hsa047441.83184479
15Basal transcription factors_Homo sapiens_hsa030221.83160155
16Protein export_Homo sapiens_hsa030601.82448797
17Alzheimers disease_Homo sapiens_hsa050101.71979511
18Fatty acid biosynthesis_Homo sapiens_hsa000611.64634660
19Olfactory transduction_Homo sapiens_hsa047401.59409893
20Selenocompound metabolism_Homo sapiens_hsa004501.55527272
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55451685
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53252006
23RNA transport_Homo sapiens_hsa030131.50335700
24RNA degradation_Homo sapiens_hsa030181.43726754
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42603197
26Taste transduction_Homo sapiens_hsa047421.39321339
27Mismatch repair_Homo sapiens_hsa034301.38444448
28Systemic lupus erythematosus_Homo sapiens_hsa053221.38186118
29Spliceosome_Homo sapiens_hsa030401.35726353
30Insulin secretion_Homo sapiens_hsa049111.30797764
31Caffeine metabolism_Homo sapiens_hsa002321.28797187
32Morphine addiction_Homo sapiens_hsa050321.24913921
33DNA replication_Homo sapiens_hsa030301.20366517
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17656864
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17411671
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16864245
37Alcoholism_Homo sapiens_hsa050341.16536418
38Dorso-ventral axis formation_Homo sapiens_hsa043201.15585997
39Purine metabolism_Homo sapiens_hsa002301.11466308
40Non-homologous end-joining_Homo sapiens_hsa034501.10889554
41Folate biosynthesis_Homo sapiens_hsa007901.06706817
42Nucleotide excision repair_Homo sapiens_hsa034201.06368489
43Pyrimidine metabolism_Homo sapiens_hsa002401.03940685
44Circadian entrainment_Homo sapiens_hsa047131.01027807
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00770826
46Hedgehog signaling pathway_Homo sapiens_hsa043400.95688682
47Proteasome_Homo sapiens_hsa030500.95515980
48One carbon pool by folate_Homo sapiens_hsa006700.94636669
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93077434
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90883235
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88453650
52Dilated cardiomyopathy_Homo sapiens_hsa054140.88248857
53Linoleic acid metabolism_Homo sapiens_hsa005910.85759345
54Tryptophan metabolism_Homo sapiens_hsa003800.83131722
55Glutamatergic synapse_Homo sapiens_hsa047240.82862172
56Base excision repair_Homo sapiens_hsa034100.81553763
57Oocyte meiosis_Homo sapiens_hsa041140.79469246
58Regulation of autophagy_Homo sapiens_hsa041400.78771167
59GABAergic synapse_Homo sapiens_hsa047270.78332315
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77689519
61Serotonergic synapse_Homo sapiens_hsa047260.77450866
62Propanoate metabolism_Homo sapiens_hsa006400.75354899
63Calcium signaling pathway_Homo sapiens_hsa040200.72042014
64Cocaine addiction_Homo sapiens_hsa050300.70373507
65Basal cell carcinoma_Homo sapiens_hsa052170.66757599
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65340976
67cAMP signaling pathway_Homo sapiens_hsa040240.64245214
68Salivary secretion_Homo sapiens_hsa049700.59793903
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57679996
70Nitrogen metabolism_Homo sapiens_hsa009100.55162971
71Dopaminergic synapse_Homo sapiens_hsa047280.55138928
72Fatty acid metabolism_Homo sapiens_hsa012120.52923548
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52856202
74mRNA surveillance pathway_Homo sapiens_hsa030150.51678966
75Metabolic pathways_Homo sapiens_hsa011000.50878101
76Collecting duct acid secretion_Homo sapiens_hsa049660.50374633
77Sulfur relay system_Homo sapiens_hsa041220.50090420
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49551286
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48648324
80Cholinergic synapse_Homo sapiens_hsa047250.48046760
81Lysine degradation_Homo sapiens_hsa003100.47811542
82Synaptic vesicle cycle_Homo sapiens_hsa047210.47265124
83Circadian rhythm_Homo sapiens_hsa047100.46859931
84Fatty acid degradation_Homo sapiens_hsa000710.46267676
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43499262
86Pancreatic secretion_Homo sapiens_hsa049720.43383371
87Wnt signaling pathway_Homo sapiens_hsa043100.43061499
88Type II diabetes mellitus_Homo sapiens_hsa049300.40873025
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.40270074
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40172032
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39774729
92Steroid biosynthesis_Homo sapiens_hsa001000.38189509
93Chemical carcinogenesis_Homo sapiens_hsa052040.37125167
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36847596
95Peroxisome_Homo sapiens_hsa041460.36520560
96Cell cycle_Homo sapiens_hsa041100.36339797
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35337532
98Ether lipid metabolism_Homo sapiens_hsa005650.34983848
99Retinol metabolism_Homo sapiens_hsa008300.34333111
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33954666

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